Group: Basic Science
General Principles & Biophysics
The biophysics of electroporation, the cellular and tissue effects of pulse parameters, drug transport mechanisms and treatment planning are gathered in this area. It is the largest section of the corpus and holds the foundational knowledge on which every other application area rests.
968total publications
59clinical publications
683preclinical publications
150reviews
1988–2026publication span
Clinical publications: randomized, prospective and retrospective studies, case series and case reports. Preclinical publications: animal, in vitro, modelling and experimental biophysics studies.
Literature Status by Method
Publication count, clinical and preclinical split, literature maturity and publication span for each clinical method. The badge at the top of the page summarises the ECT record only; the full split by method is here.
Electrochemotherapy (ECT)
245publications
30clinical publications
151preclinical publications
Exploratory literaturethreshold 8/245
Validated records entering the maturity calculation: 8 (clinical 0, preclinical 3), 3% of the records for this method.
1991–2026
Irreversible electroporation (IRE)
211publications
12clinical publications
153preclinical publications
Preclinical literaturethreshold 17/211
Validated records entering the maturity calculation: 17 (clinical 2, preclinical 12), 8% of the records for this method.
2005–2026
Pulsed-field ablation (PFA)
3publications
0clinical publications
2preclinical publications
Exploratory literaturethreshold 0/3
No record for this method entered the maturity calculation; the records are marked in the validation ledger as conflicting, insufficient or out of scope.
2022–2024
Calcium electroporation
23publications
0clinical publications
18preclinical publications
Exploratory literaturethreshold 1/23
Validated records entering the maturity calculation: 1 (clinical 0, preclinical 1), 4% of the records for this method.
2012–2026
Gene electrotransfer
77publications
0clinical publications
63preclinical publications
Exploratory literaturethreshold 3/77
Validated records entering the maturity calculation: 3 (clinical 0, preclinical 0), 4% of the records for this method.
1999–2026
Other electroporation applications
400publications
16clinical publications
292preclinical publications
This set does not name a single clinical method; no literature maturity is assigned.
1988–2026
Records with no determined method
9publications
1clinical publication
4preclinical publications
This set does not name a single clinical method; no literature maturity is assigned.
2011–2026
Mechanisms Mentioned in Abstracts
Mechanism names are detected by automatic matching over publication abstracts; the figure is the number of publications containing the name. A mention does not mean the mechanism was demonstrated in that study.
Reversible Membrane Permeabilisation 412
Irreversible Pore Formation and Cell Death 249
Electric Field Distribution and Modelling 204
Gene Electrotransfer (Plasmid DNA) 174
Optimisation of Pulse Parameters 169
Tissue Conductivity and Impedance Change 125
Potentiation of Cytotoxic Drug Permeability 118
Increased Intracellular Bleomycin Accumulation 118
Electrode Geometry and Placement 108
Thermal Effect and Joule Heating 69
Increased Intracellular Cisplatin Accumulation 52
Apoptosis Induction 46
Study Type Distribution
Bar length is scaled to the most common study type; the percentage gives the share of the whole area. Colour marks the study-type band, on the same scale as the literature map.
| Study type | Publications | Share within this area |
|---|---|---|
| Randomized Clinical Trial | 1 | <1% |
| Prospective Clinical Study | 8 | <1% |
| Clinical Study | 44 | 5% |
| Retrospective Clinical Study | 1 | <1% |
| Case Series | 1 | <1% |
| Case Report | 4 | <1% |
| Systematic Review / Meta-Analysis | 14 | 1% |
| Guideline / Consensus | 1 | <1% |
| Review | 136 | 14% |
| Animal Study | 348 | 36% |
| In Vitro Study | 190 | 20% |
| In Silico / Modelling | 113 | 12% |
| Technical / Device Study | 21 | 2% |
| Experimental Biophysics Study | 32 | 3% |
| Preprint | 5 | <1% |
| Thesis | 1 | <1% |
| Conference Abstract | 10 | 1% |
| Editorial / Letter | 11 | 1% |
| Correction / Erratum | 2 | <1% |
| Not reported | 25 | 3% |
Literature Evidence Table
968 publications listed in order of evidence strength. Click a title to open the citation, mechanism and full abstract drawer.
The study type, model and mechanism columns are assigned automatically and can be wrong for individual records; the abstract column is taken either from the publication's own abstract or from the opening text of the source PDF. The labels are there for scanning and filtering, not as record-level verified data; consult the full text before acting on any single publication. The classification rules and known errors are on the Literature Map.
| Regime | Publication | Year | Study type | Model | Mechanism | Abstract |
|---|---|---|---|---|---|---|
| Other EP | Hu et al · Medicine (Baltimore) | 2022 | Randomized Clinical Trial | Human | Increased Intracellular Cisplatin Accumulation | To explore the efficacy of low-frequency electric pulse therapy (LFEPT) combined with 2 antiemetics in the prevention and treatment of cisplatin-based chemotherapy-induced nausea and vomitin… |
| ECT | Di Chiacchio et al · J Eur Acad Dermatol Venereol | 2019 | Prospective Clinical Study | Human | Increased Intracellular Bleomycin Accumulation | Background: Ungual warts are considered the most common benign nail tumour, and they are caused by the human papillomavirus. Despite the numerous treatments reported in the medical literatur… |
| ECT | Groselj et al · Cancer Chemother Pharmacol | 2016 | Prospective Clinical Study | Human | Increased Intracellular Bleomycin Accumulation, Necrosis and Necroptosis | Purpose: With the aim to determine effective therapeutic window of electrochemotherapy, we analyzed bleomycin pharmacokinetic parameters in elderly patients. Methods: In prospective clinical… |
| Other EP | Meir et al · Biomed Microdevices | 2014 | Prospective Clinical Study | Human | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | A living cell placed in a high strength electric field, can undergo a process known as electroporation. It is believed that during electroporation nano-scale defects (pores) occur in the mem… |
| IRE | Thomson et al · J Vasc Interv Radiol | 2011 | Prospective Clinical Study | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Purpose: A single-center prospective nonrandomized cohort study was performed to investigate the safety of irreversible electroporation (IRE) for tumor ablation in humans. Materials and meth… |
| Other EP | Yuan et al · Int Arch Med | 2010 | Prospective Clinical Study | Human | – | The development and application of single neuron electroporation largely advanced the use of traditional genetics in investigations of the central nervous system. This quick and accurate man… |
| Other EP | Davalos et al · IEEE Trans Biomed Eng | 2002 | Prospective Clinical Study | Human | Tissue Conductivity and Impedance Change | Molecular medicine involves the introduction of macromolecules, such as drugs or gene constructs, into specific cells of the body. Electroporation, which uses electric pulses to permeate cel… |
| Other EP | Zhang et al · Bioelectrochem Bioenerg | 1999 | Prospective Clinical Study | Human | – | It is now medically recognized that sagging skin and other signs of degenerative skin conditions, such as wrinkles and age spots, are caused primarily by oxy-radical damage. Vitamin C (Vit. … |
| ECT | C Domenge, S Orlowski, B Luboinski, T Baere, G Schwaab, J Belehradek · Cancer | 1996 | Prospective Clinical Study | Human | Increased Intracellular Bleomycin Accumulation | Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in… |
| ECT | Alkis et al · Inorganic Chemistry Communications | 2026 | Clinical Study | Human | – | This publication has no abstract. |
| Other EP | · – | 2026 | Clinical Study | Human | Immune Checkpoint Inhibitor Combination | The Unmet Need in Solid Tumor Immunotherapy approach combining bacterial outer membrane vesicles (OMVs), nucleic acid nanocarriers, and The advent of immune checkpoint inhibitors and electro… |
| ECT | Abadijoo et al · Sensors and Actuators A: Physical | 2025 | Clinical Study | Human | – | This publication has no abstract. |
| Other EP | Sutter et al · IEEE Trans Biomed Eng | 2024 | Clinical Study | Human | Tissue Conductivity and Impedance Change | In this article we investigate the possibility of using needles, which the interventional radiologist inserts near a deep-seated tumor during an electroporation-based therapy, to characteriz… |
| ECT | Odeyemi et al · IRJMETS | 2023 | Clinical Study | Human | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | Electroporation is the process of temporarily creating openings in the cell membrane by exposing it to a shortterm electric field.In addition to creating openings in the membrane, electropor… |
| ECT | Rózsa et al · Orv Hetil | 2023 | Clinical Study | Human | Increased Intracellular Bleomycin Accumulation | Introduction: The risk of cutaneous malignancies is significantly higher in immunosuppressed patients compared to the general population. These high-risk skin tumors tend to be aggressive, m… |
| ECT | Marcasciano et al · Eur J Plast Surg | 2022 | Clinical Study | Human | – | This publication has no abstract. |
| ECT | Pfefferle et al · J Dtsch Dermatol Ges | 2022 | Clinical Study | Human | Increased Intracellular Bleomycin Accumulation, Immune Checkpoint Inhibitor Combination | Seit einigen Jahren besteht mit der Elektrochemotherapie (ECT) eine zusätzliche Therapieoption zur Behandlung kutaner und subkutaner Metastasen. Das Wirkungsprinzip dieses Verfahrens besteht… |
| ECT | Skorupska et al · Sensors and Actuators B: Chemical | 2022 | Clinical Study | Human | – | This publication has no abstract. |
| ECT | Groselj et al · Pharmaceutics | 2021 | Clinical Study | Human | Increased Intracellular Bleomycin Accumulation | The plasma concentration profile of bleomycin in the distribution phase of patients younger than 65 years is needed to determine the suitable time interval for efficient application of elect… |
| IRE | Hilton et al · British Journal of Surgery | 2021 | Clinical Study | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Introduction Thermal tumour ablation techniques are effective alternatives to nephrectomy for small renal masses (SRM). Thermal effects limit their use in tumours adjacent to vital structure… |
| Other EP | Tartaglia et al · Clin Exp Dent Res | 2020 | Clinical Study | Human | – | Objective(s): It is well appreciated that traditional analgesic delivery routes used to treat pain associated with temporomandibular disorder (TMD) often have harmful unintended side effects… |
| ECT | Celik ve Bektas · HEAD | 2020 | Clinical Study | Human | – | Elektrokemoterapi farklı histolojilerdeki tümörlerin tedavisinde kemoterapi ilaçlarının elektroporasyon yöntemiyle uygulanmasıdır. Elektroporasyon ile hücre membranının geçirgenliği artırılı… |
| IRE | Petrella et al · IEEE Trans Biomed Eng | 2020 | Clinical Study | Human | Irreversible Pore Formation and Cell Death, Thermal Effect and Joule Heating | Objective: To evaluate the effect of a closed-loop temperature based feedback algorithm on ablative outcomes for pulsed electric field treatments. Methods: A 3D tumor model of glioblastoma w… |
| Other EP | Pirc et al · Journal of Medical Devices | 2020 | Clinical Study | Human | Optimisation of Pulse Parameters | Electroporation-based therapies have a huge potential for implementation into clinical practice in socioeconomically disadvantaged populations. Currently, the price of electroporators and el… |
| IRE | Sano et al · Ann Biomed Eng | 2020 | Clinical Study | Human | Thermal Effect and Joule Heating, Reversible Membrane Permeabilisation | Thermal tissue injury is an unintended consequence in current irreversible electroporation treatments due to the induction of Joule heating during the delivery of high voltage pulsed electri… |
| ECT | Anon · J. adv. ethnol. eng. res. | 2017 | Clinical Study | Human | Optimisation of Pulse Parameters, Muscle Contraction and Anaesthesia Requirement | Electrochemotherapy is a combined use of a chemotherapeutic drug and short intense electric ield for cancer treatment. The applied electric ield increases the permeability of the cell membra… |
| ECT | Grošelj et al · Clinical Therapeutics | 2017 | Clinical Study | Human | Increased Intracellular Bleomycin Accumulation | Few studies have assessed concentrations of fatty acid ethyl esters (FAEEs) after controlled administration of wide range of alcohol doses in both genders. The objective was to assess the ti… |
| IRE | Clark et al · HPB | 2017 | Clinical Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | OPORATION (H-FIRE) IN A PORCINE PANCREATIC CANCER TREATMENT MODEL C. Clark, C. Byron, S. Bhonsle, M. Lorenzo, C. Arena, J. Robertson and R. Davalos Wake Forest Baptist Health, Winston Salem,… |
| ECT | Sundararajan · JCPCR | 2016 | Clinical Study | Human | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Electro oration is the application of electrical pulses for enhanced drug delivery. When used for delivering chemo drugs, it is called electrochemotherapy (ECT). For inoperable and chemo- an… |
| IRE | Bonakdar et al · Biophysical Journal | 2016 | Clinical Study | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | This publication has no abstract. |
| ECT | Quaglino et al · Acta Oncol | 2015 | Clinical Study | Human | Increased Intracellular Bleomycin Accumulation, Muscle Contraction and Anaesthesia Requirement | Background: Electrochemotherapy describes the use of electric pulses to enhance chemotherapy uptake, and has proven highly efficient in treating cutaneous metastases. Patients referred for e… |
| ECT | Castiello et al · IEEE Trans. Dielect. Electr. Insul. | 2014 | Clinical Study | Human | – | Electrochemotherapy (ECT) is a local anticancer treatment for superficial tumors which involves the administration of a chemotherapeutic drug followed by short, high-voltage pulses. Incipien… |
| ECT | Valpione et al · Annals of Oncology | 2014 | Clinical Study | Human | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | Background: electroporation, an effective drug delivery system, enhances the uptake of chemotherapeutic agents by means of short electrical fields which open transient pores on the cell memb… |
| ECT | O'Brien et al · J Immunother Cancer | 2014 | Clinical Study | Human | – | Meeting abstracts The correlation between the level of immune involvement and immune cell infiltration within a treated tumour and the clinical outcome for patients has been well established… |
| ECT | Castiello et al · IEEE Trans. Dielect. Electr. Insul. | 2014 | Clinical Study | Human | – | Electrochemotherapy (ECT) is a local anticancer treatment for superficial tumors which involves the administration of a chemotherapeutic drug followed by short, high-voltage pulses. Incipien… |
| IRE | Nielsen et al · Br J Anaesth | 2014 | Clinical Study | Human | Irreversible Pore Formation and Cell Death, Muscle Contraction and Anaesthesia Requirement | Background Irreversible electroporation (IRE) is a novel tumour ablation technique involving repetitive application of electrical energy around a tumour. The use of pulsed electrical gradien… |
| IRE | Narayanan et al · Cardiovasc Intervent Radiol | 2014 | Clinical Study | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Purpose: The purpose of the study was to evaluate the effect of Irreversible Electroporation (IRE) on vessel patency in close proximity to the ablation zone. Materials and methods: Between J… |
| IRE | Pavliha et al · J Membr Biol | 2013 | Clinical Study | Human | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | Electroporation-based treatment combining high-voltage electric pulses and poorly permanent cytotoxic drugs, i.e., electrochemotherapy (ECT), is currently used for treating superficial tumor… |
| Other EP | Diaz et al · J Transl Med | 2013 | Clinical Study | Human | Gene Electrotransfer (Plasmid DNA) | Background: DNA electroporation has been demonstrated in preclinical models to be a promising strategy to improve cancer immunity, especially when combined with other genetic vaccines in het… |
| ECT | Hampton · JAMA | 2011 | Clinical Study | Human | – | FOR NEARLY 3 DECADES, BASIC SCIence researchers have used electric pulses to make cell membranes transiently permeable to deliver DNA and other molecules into cells. Now, clinical investigat… |
| ECT | Skarlatos et al · In Vivo | 2011 | Clinical Study | Human | Increased Intracellular Bleomycin Accumulation | Electrochemotherapy is currently undergoing intensive investigation in the field of local control of cancer. In Greece, five medical centers have co-operated to perform ECT for the efficient… |
| Other EP | Kotulska et al · Biophysical Journal | 2010 | Clinical Study | Human | Tissue Conductivity and Impedance Change | This publication has no abstract. |
| Other EP | Laufer et al · Physiol Meas | 2010 | Clinical Study | Human | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | The four-electrode method was used to measure the ex vivo complex electrical impedance of tissues from 14 hepatic tumors and the surrounding normal liver from six patients. Measurements were… |
| ECT | Guida et al · European Journal of Cancer Supplements | 2008 | Clinical Study | Human | Muscle Contraction and Anaesthesia Requirement | ECT is an effective local treatment for palliation on inoperable superficial neoplastic localizations which combines surgical debulking had a disease control for a long period (8 months, med… |
| ECT | Pavlovic et al · IEEE Trans Inf Technol Biomed | 2007 | Clinical Study | Human | – | Many branches of the healthcare industry are being influenced by information and communication technology (ICT). Clinical trials are not an exception. Despite this fact, more than 75% of cli… |
| ECT | Zupanic et al · Neoplasma | 2007 | Clinical Study | Human | Optimisation of Pulse Parameters, Muscle Contraction and Anaesthesia Requirement | Involuntary muscle contractions and painful sensations during electric pulse delivery are the most unpleasant side effects of electrochemotherapy. The aim of this study was to determine the … |
| ECT | Mir · European Journal of Cancer Supplements | 2006 | Clinical Study | Human | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Electrochemotherapy is defined as the local potentiation, by means of permeabilizing electric pulses, of the antitumour activity of a non-permeant (or a low-permeant) anticancer drug possess… |
| Other EP | Ruggiero et al · Journal of the American Academy of Dermatology | 2005 | Clinical Study | Human | – | T SKIN ELECTROPORATION Marco Ruggiero, MD, PhD, Department of Experimental Pathology and Oncology, Florence, Italy; Stefania Pacini, MD, PhD, Gianfranco Bernabei, Department of Anatomy, Hist… |
| IRE | Davalos et al · Ann Biomed Eng | 2005 | Clinical Study | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | This study introduces a new method for minimally invasive treatment of cancer-the ablation of undesirable tissue through the use of irreversible electroporation. Electroporation is the perme… |
| ECT | Spugnini et al · J Exp Clin Cancer Res | 2003 | Clinical Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | The objectives of this phase I/II study were: i) to determine whether electrochemotherapy (intralesional bleomycin + electric pulses) could be effective in companion animals with different, … |
| Other EP | Rabussay et al · Technol Cancer Res Treat | 2002 | Clinical Study | Human | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Many conventional chemotherapeutic drugs, as well as DNA for cancer gene therapy, require efficient access to the cell interior to be effective. The cell membrane is a formidable barrier to … |
| ECT | Daskalov et al · IEEE Eng Med Biol Mag | 1999 | Clinical Study | Human | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | Electrochemotherapy using rectangular biphasic stimuli and bursts of stimuli, as compared to using monophasic pulses obtained by capacitor discharge, are at least of the same efficacy. The u… |
| ECT | Serša et al · Eur J Cancer | 1998 | Clinical Study | Human | Increased Intracellular Cisplatin Accumulation, Potentiation of Cytotoxic Drug Permeability | This study was aimed at assessing the response to electrochemotherapy with cisplatin of cutaneous tumour nodules in patients with malignant melanoma, squamous cell carcinoma and basal cell c… |
| Other EP | Narayanan · Curr Oncol | 2025 | Retrospective Clinical Study | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The purpose was to determine the ability of 18-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) scans performed within 24 h of percutaneous image-guided… |
| IRE | Ozdemir Simsek et al · BMC Anesthesiol | 2026 | Case Series | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Background: Irreversible electroporation is a novel, non-thermal tumor ablation technique that induces cell death through electrical disruption of cellular membranes while preserving surroun… |
| Undetermined | A Šenk Juh, B Šenk, M Čemažar · Medicinski razgledi | 2026 | Case Report | Human | – | – Amadej Šenk Juh, Barbara Šenk, Maja Čemažar 99 Diagnostični izziv 99 Diagnostic Challenge 105 Seznam diplomantov 105 List of Graduated Students 107 Navodila avtorjem 113 Guidelines for Aut… |
| IRE | Araújo et al · J Cardiothorac Vasc Anesth | 2025 | Case Report | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Anesthesia for Irreversible Electroporation in Patients with a Pacemaker Guilherme Freitas Ara ujo, MD, TSA*, Marcelo Froeder Arcuri, MDy, Veronica Neves Fialho Queiroz, MD, PhD*, Guilherme… |
| ECT | Marandola et al · WJA | 2013 | Case Report | Human | – | Electrochemotherapy and heart function: Treatment in a patient with implantable cardioverter defibrillator/pace-maker |
| Other EP | Daniels et al · PLoS One | 2011 | Case Report | Human | Muscle Contraction and Anaesthesia Requirement | Pulsed electric fields (PEF) have become an important minimally invasive surgical technology for various applications including genetic engineering, electrochemotherapy and tissue ablation. … |
| ECT | Altamura et al · International Journal of Clinical Practice | 2026 | Systematic Review / Meta-Analysis | Human | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | Background Electrochemotherapy (ECT) is a nonthermal locoregional treatment that enhances cytotoxic drug uptake through reversible electroporation and is increasingly used across different m… |
| ECT | Formstone et al · Eur Radiol | 2026 | Systematic Review / Meta-Analysis | Human | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Objectives: To systematically review the available evidence on electrochemotherapy (ECT) in pediatric patients, focusing on indications, treatment parameters, efficacy, and safety. Materials… |
| ECT | Ferioli et al · Curr Oncol | 2023 | Systematic Review / Meta-Analysis | Human | – | Radiotherapy (RT) and electrochemotherapy (ECT) are established local treatments for cancer. While effective, both therapies have limitations, especially in treating bulky and poorly oxygena… |
| IRE | Hogenes · Technol Cancer Res Treat | 2023 | Systematic Review / Meta-Analysis | Animal (In Vivo) | Thermal Effect and Joule Heating, Reversible Membrane Permeabilisation | Introduction: The aim of this study was to review the effect of irreversible electroporation parameter settings on the size of the ablation zone and the occurrence of thermal effects. This i… |
| Gene ET | Potočnik et al · Pharmaceutics | 2022 | Systematic Review / Meta-Analysis | Literature Analysis | Gene Electrotransfer (Plasmid DNA) | The exact mechanisms of nucleic acid (NA) delivery with gene electrotransfer (GET) are still unknown, which represents a limitation for its broader use. Further, not knowing the effects that… |
| IRE | Granata et al · Int J Environ Res Public Health | 2021 | Systematic Review / Meta-Analysis | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: Imaging methods and the most appropriate criteria to be used for detecting and evaluating response to oncological treatments depend on the pathology and anatomical site to be tre… |
| IRE | Agnass et al · Int J Hyperthermia | 2020 | Systematic Review / Meta-Analysis | Computational Model | Irreversible Pore Formation and Cell Death, Thermal Effect and Joule Heating | Introduction: Irreversible electroporation (IRE) is a relatively new ablation method for the treatment of unresectable cancers. Although the main mechanism of IRE is electric permeabilizatio… |
| IRE | O'Neill et al · J Surg Oncol | 2020 | Systematic Review / Meta-Analysis | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background and objectives: Irreversible electroporation (IRE) is a nonthermal electrical tumor ablative strategy for unresectable tumors. IRE is relatively safe around critical structures bu… |
| ECT | Cen et al · J Healthc Eng | 2017 | Systematic Review / Meta-Analysis | Human | Preservation of Nerve and Vascular Structures, Electrode Geometry and Placement | Pulsed electric field treatment is now widely used in diverse biological and medical applications: gene delivery, electrochemotherapy, and cancer therapy. This minimally invasive technique h… |
| ECT | Campana et al · Radiol Oncol | 2016 | Systematic Review / Meta-Analysis | Literature Analysis | – | Background: Electrochemotherapy is becoming a well-established treatment for malignancies of skin and non-skin origin and its use is widening across Europe. The technique was developed and o… |
| IRE | Vogel et al · PLoS One | 2016 | Systematic Review / Meta-Analysis | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Apoptosis Induction | Introduction: Irreversible electroporation (IRE) is a novel ablation technique in the treatment of unresectable cancer. The non-thermal mechanism is thought to cause mostly apoptosis compare… |
| ECT | Mali et al · Radiol Oncol | 2013 | Systematic Review / Meta-Analysis | Literature Analysis | Electric Field Distribution and Modelling | Background: Electrochemotherapy (ECT) is an effective and safe method for local treatment of tumors. However, relatively large variability in effectiveness of ECT has been observed, which li… |
| ECT | Mali et al · Eur J Surg Oncol | 2013 | Systematic Review / Meta-Analysis | Human | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Background: This systematic review has two purposes: to consolidate the current knowledge about clinical effectiveness of electrochemotherapy, a highly effective local therapy for cutaneous … |
| ECT | Marone · J Clin Case Rep | 2012 | Systematic Review / Meta-Analysis | Literature Analysis | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Open Access Electrochemotherapy: A New Arm against Cancer Ugo Marone* Department of Surgery “Melanoma, Soft Tissues, Head and Neck and Skin Cancers” National Cancer Institute of Naples, Ital… |
| ECT | Mir et al · European Journal of Cancer Supplements | 2006 | Guideline / Consensus | Human | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | This publication has no abstract. |
| Other EP | Cai et al · Adv Mater | 2026 | Review | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Mitochondrial Dysfunction and Oxidative Stress | Inspired by endogenous physiological electric fields, electro-mediated therapeutic strategies represent promising approaches for targeted cancer therapy owing to their deep tissue penetratio… |
| Other EP | Hu et al · Research (Wash D C) | 2026 | Review | – | Potentiation of Cytotoxic Drug Permeability, Gene Electrotransfer (Plasmid DNA) | Bioelectronic patches have emerged as promising tools for localized and precise intracellular delivery. However, their application is limited by poor conformability and suboptimal delivery e… |
| ECT | Liu et al · Int. J. Extrem. Manuf. | 2026 | Review | Literature Analysis | Potentiation of Cytotoxic Drug Permeability | Microneedles (MNs) have emerged as a transformative minimally invasive platform in biomedicine, enabling painless transdermal drug delivery and diagnostic applications. However, conventional… |
| IRE | Miklavčič · Bioelectrochemistry | 2026 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Electroporation has birthed two massive parallel universes of applications: medicine and food processing. Despite operating on the same fundamental physics, these fields fail to crosspollina… |
| ECT | Saeed et al · J Control Release | 2026 | Review | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Electric Field Distribution and Modelling | Tissue penetration of anticancer drugs is hindered by adverse biophysical properties of solid tumors, including elevated interstitial fluid pressure, dense extracellular matrices, and abnorm… |
| Other EP | Shi et al · Front Oncol | 2026 | Review | Literature Analysis | Immunogenic Cell Death (ICD), Immune Checkpoint Inhibitor Combination | Tumor Treating Fields (TTFields) and pulsed electric fields (PEF) have emerged as a fourth modality in oncological treatment, succeeding surgery, radiotherapy, and pharmacotherapy. However, … |
| Other EP | Tian et al · J Cancer Res Ther | 2026 | Review | Literature Analysis | – | Background: Pulsed electric field (PEF) ablation is a promising nonthermal tumor treatment for liver cancer, recognized for its ability to induce immune responses. However, the field has lac… |
| Other EP | Truong et al · Biomater Res | 2026 | Review | Literature Analysis | Potentiation of Cytotoxic Drug Permeability, Reversible Membrane Permeabilisation | Electric field-based therapies are rapidly emerging as innovative modalities in the fight against cancer, offering targeted, minimally invasive, and often immunomodulatory alternatives to co… |
| Other EP | Liu et al · Adv Drug Deliv Rev | 2026 | Review | Animal (In Vivo) | Electric Field Distribution and Modelling, Thermal Effect and Joule Heating | Intracellular delivery of therapeutic biomolecules represents a fundamental prerequisite for cell-based therapies and precision medicine, yet existing delivery methods present critical limit… |
| Other EP | Gehl et al · Radiol Oncol | 2026 | Review | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The field of oncology has witnessed remarkable progress with the integration of high-tech innovations in tumor ablation. Tumor ablation therapies, such as radiofrequency ablation (RFA), micr… |
| IRE | Hossain · – | 2026 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death | This publication has no abstract. |
| IRE | Ji et al · Small | 2026 | Review | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Electroporation has evolved from a membrane-permeabilization method into a versatile therapeutic platform for intracellular delivery, locoregional tumor intervention, and bioelectrically reg… |
| IRE | Liu · Prostate Int | 2026 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Prostate cancer (PCa) is the second most commonly diagnosed malignancy in men. Radical treatments such as radical prostatectomy and radiotherapy can be associated with morbidity that impact … |
| ECT | Morozas et al · Biomed Pharmacother | 2025 | Review | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Electrochemotherapy (ECT) is a popular clinical anticancer treatment modality that combines chemotherapy with electroporation to enhance drug uptake by tumor cells. One of its key advantages… |
| Calcium EP | Szewczyk et al · Biochim Biophys Acta Rev Cancer | 2025 | Review | Animal (In Vivo) | Calcium Electroporation and ATP Depletion | Calcium electroporation, an innovative technique, uses high-voltage pulses to introduce calcium ions into cells, leading to cell death and tumor growth inhibition. This review explores the p… |
| Gene ET | Jesenko · Radiol Oncol | 2025 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Background: Gene therapy has emerged as a transformative biomedical approach, offering new therapeutic possibilities from many so far uncurable diseases through the introduction of recombina… |
| ECT | Ferioli et al · Technol Cancer Res Treat | 2025 | Review | Human | Potentiation of Cytotoxic Drug Permeability | This narrative review explores the potential role of electrochemotherapy (ECT) in treating anorectal tumors, focusing on its effectiveness, feasibility, and associated toxicities. ECT, which… |
| Other EP | Chikovani et al · Vaccines (Basel) | 2025 | Review | Literature Analysis | Immunogenic Cell Death (ICD), Irreversible Pore Formation and Cell Death | Cancer immunotherapy has redefined oncology's goals, aiming for durable systemic immunity rather than mere cytoreduction. However, many solid tumors remain refractory due to immunosuppressiv… |
| IRE | Vallin et al · Annu Rev Chem Biomol Eng | 2025 | Review | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a nonthermally mediated tissue ablation modality that makes use of short pulsed electric fields to destroy cancerous lesions in situ. In the past two de… |
| Gene ET | Shiwani et al · Br J Radiol | 2024 | Review | Human | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Reversible electroporation (EP) refers to the use of high-voltage electrical pulses on tissues to increase cell membrane permeability. It allows targeted delivery of high concentrations of c… |
| Other EP | Taghdiri et al · Int J Mol Sci | 2024 | Review | Animal (In Vivo) | – | Clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has revolutionized the field of gene therapy as it has enabled precise genom… |
| Undetermined | Universitat des Saarlandes · – | 2024 | Review | Literature Analysis | – | This publication has no abstract. |
| Other EP | Zhou et al · Adv Sci (Weinh) | 2024 | Review | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability | Intracellular delivery of nano-drug-carriers (NDC) to specific cells, diseased regions, or solid tumors has entered the era of precision medicine that requires systematic knowledge of nano-b… |
| ECT | Ferioli et al · Curr Oncol | 2024 | Review | Animal (In Vivo) | Systemic / Abscopal Immune Response, Immunogenic Cell Death (ICD) | Electrochemotherapy (ECT) is an emerging therapeutic approach gaining growing interest for its potential immunomodulatory effects in cancer treatment. This narrative review systematically ex… |
| ECT | Hadzialjevic et al · Front Immunol | 2024 | Review | Human | Immunogenic Cell Death (ICD), Systemic / Abscopal Immune Response | Electrochemotherapy is a novel, locoregional therapy that is used to treat cutaneous and deep-seated tumors. The electric pulses used in electrochemotherapy increase the permeability of the … |
| IRE | De Cillis et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2024 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | The adoption of high-frequency irreversible electroporation in various medical treatments is becoming increasingly prevalent. There is currently a special focus on its applications in oncolo… |
| Other EP | Zhao · Phenomics | 2024 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Pyroptosis is a newly recognized type of programmed cell death mediated by the gasdermin family and caspase. It is characterized by the formation of inflammasomes and the following inflammat… |
| Other EP | Brno University of Technology · – | 2023 | Review | Literature Analysis | Mitochondrial Dysfunction and Oxidative Stress, Reversible Membrane Permeabilisation | Electroporation utilizes high-intensity voltage pulses to permeabilize the cell membranes, serving as a staple technique across biotechnology and medicine. While the primary mechanism - pore… |
| Calcium EP | Campana et al · Cancers (Basel) | 2023 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The 4th World Congress of Electroporation (Copenhagen, 9-13 October 2022) provided a unique opportunity to convene leading experts in pulsed electric fields (PEF). PEF-based therapies harnes… |
| ECT | Ottlakan et al · Electrochem | 2023 | Review | Literature Analysis | Increased Intracellular Bleomycin Accumulation | Electrochemotherapy (ECT) has evolved significantly during the last decade, expanding treatment indications from superficial skin lesions to advanced-stage, deep-seated tumors in hard-to-rea… |
| Other EP | Qian et al · Biomed Tech (Berl) | 2023 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Objectives: Electroporation, the breakdown of the biomembrane induced by external electric fields, has increasingly become a research hotspot for its promising related methods in various kin… |
| Other EP | Campelo et al · Annu Rev Biomed Eng | 2023 | Review | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability | Over the past decade, the increased adoption of electroporation-based technologies has led to an expansion of clinical research initiatives. Electroporation has been utilized in molecular bi… |
| IRE | Peng et al · Adv Healthc Mater | 2023 | Review | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | In this work, we proposed nµPEF, a novel pulse configuration combining nanosecond and microsecond pulses (nµPEF), to enhance tumor ablation in irreversible electroporation (IRE) for oncologi… |
| ECT | Condello et al · Cancers (Basel) | 2022 | Review | Literature Analysis | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Electrochemotherapy (ECT) is one of the innovative strategies to overcome the multi drug resistance (MDR) that often occurs in cancer. Resistance to anticancer drugs results from a variety o… |
| IRE | Tasu et al · Diagn Interv Imaging | 2022 | Review | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Thermal tumor ablation techniques including radiofrequency, microwave, LASER, high-intensity focused ultrasound and cryoablation are routinely used to treated liver, kidney, bone, or lung tu… |
| ECT | Tsoneva et al · Biophys Chem | 2022 | Review | Human | Potentiation of Cytotoxic Drug Permeability | This review focuses on electrochemotherapy that consists in the delivery of anti-cancer drugs using high-voltage electrical pulses. Technical issues, choice of drugs, and protocol of drug de… |
| ECT | Bendix et al · Eur J Surg Oncol | 2022 | Review | Human | Systemic / Abscopal Immune Response | Electrochemotherapy (ECT), the application of an electric impulse to deliver chemotherapy drugs into cells, has been in clinical trials since the early 1990s and has been used for a variety … |
| ECT | Das et al · Front Bioeng Biotechnol | 2022 | Review | Literature Analysis | Immunogenic Cell Death (ICD) | Immunotherapy is becoming a very common treatment for cancer, using approaches like checkpoint inhibition, T cell transfer therapy, monoclonal antibodies and cancer vaccination. However, the… |
| Gene ET | Sachdev et al · Bioelectrochemistry | 2022 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Gene therapies are revolutionizing medicine by providing a way to cure hitherto incurable diseases. The scientific and technological advances have enabled the first gene therapies to become … |
| Other EP | E Sabri · – | 2022 | Review | Literature Analysis | Electric Field Distribution and Modelling | This publication has no abstract. |
| Gene ET | Rakoczy et al · Applied Sciences | 2022 | Review | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Electroporation (EP) allows for the transport of molecules into the cytoplasm with significant effectiveness by forming transient pores in the cell membrane using electric pulses. This can b… |
| IRE | Gong · Vaccines (Basel) | 2022 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Apoptosis Induction | Electroporation is the process of instantaneously increasing the permeability of a cell membrane under a pulsed electric field. Depending on the parameters of the electric pulses and the tar… |
| PFA | Wang · Front Oncol | 2022 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Pulsed field ablation can increase membrane permeability and is an emerging non-thermal ablation. While ablating tumor tissues, electrical pulses not only act on the membrane structure of ce… |
| IRE | Zhang et al · Front Immunol | 2022 | Review | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE), a novel non-thermal ablation technique, is utilized to ablate unresectable solid tumors and demonstrates favorable safety and efficacy in the clinic. IRE … |
| ECT | Fusco et al · World J Clin Oncol | 2021 | Review | Human | Muscle Contraction and Anaesthesia Requirement, Electrode Geometry and Placement | Background: In the first studies of electrochemotherapy (ECT), small cutaneous metastases were treated and only mild or moderate pain was observed; therefore, pain was not considered a signi… |
| Other EP | Aguilar et al · Cancers (Basel) | 2021 | Review | Literature Analysis | Electric Field Distribution and Modelling | The biological impact of exogenous, alternating electric fields (AEFs) and direct-current electric fields has a long history of study, ranging from effects on embryonic development to influe… |
| Other EP | Balantič et al · Acta Chim Slov | 2021 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Electroporation is used to increase the permeability of the cell membrane through high-voltage electric pulses. Nowadays, it is widely used in different areas, such as medicine, biotechnolog… |
| ECT | Bonferoni et al · Cancers (Basel) | 2021 | Review | Literature Analysis | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Surgical resection is the gold standard for the treatment of many kinds of tumor, but its success depends on the early diagnosis and the absence of metastases. However, many deep-seated tumo… |
| Other EP | Hur et al · Adv Sci (Weinh) | 2021 | Review | Human | Gene Electrotransfer (Plasmid DNA) | Innate cell function can be artificially engineered and reprogrammed by introducing biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the cytosol or nucleus. T… |
| Gene ET | Luz et al · Vaccines (Basel) | 2021 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique… |
| Other EP | Batista Napotnik et al · Bioelectrochemistry | 2021 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Exposure of cells to high voltage electric pulses increases transiently membrane permeability through membrane electroporation. Electroporation can be reversible and is used in gene transfer… |
| ECT | Sersa et al · Eur J Surg Oncol | 2021 | Review | Human | Preservation of Extracellular Matrix and Tissue Scaffold | The beneficial effects of electrochemotherapy (ECT) for superficial tumours and, more recently, deep-seated malignancies in terms of local control and quality of life are widely accepted. Ho… |
| Other EP | Brock et al · Front Oncol | 2020 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | New therapeutic strategies and paradigms are direly needed for the treatment of cancer. While the surgical removal of tumors is favored in most cancer treatment plans, resection options are … |
| IRE | Graybill et al · Cancers (Basel) | 2020 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the trea… |
| Gene ET | Geboers et al · Radiology | 2020 | Review | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). HVE… |
| Other EP | Gantenbein et al · Front Bioeng Biotechnol | 2020 | Review | Literature Analysis | Gene Electrotransfer (Plasmid DNA) | Viral carrier transport efficiency of gene delivery is high, depending on the type of vector. However, viral delivery poses significant safety concerns such as inefficient/unpredictable repr… |
| Other EP | Cvetkoska et al · IEEE Instrum. Meas. Mag. | 2020 | Review | Literature Analysis | – | Cell exposure to high-voltage, short-duration electric pulses can lead to temporary formation of hydrophilic pores in the plasma membrane and an increase in the membrane's permeability which… |
| Other EP | Dermol-Černe et al · Expert Opin Drug Deliv | 2020 | Review | Animal (In Vivo) | Electrode Geometry and Placement, Potentiation of Cytotoxic Drug Permeability | Introduction : Skin electroporation is a promising treatment for transdermal drug delivery, gene electrotransfer, skin rejuvenation, electrochemotherapy, and wound disinfection. Although a c… |
| Calcium EP | Frandsen et al · Cancers (Basel) | 2020 | Review | Literature Analysis | Calcium Electroporation and ATP Depletion, Systemic / Abscopal Immune Response | Calcium electroporation is a potential novel anti-cancer treatment where high calcium concentrations are introduced into cells by electroporation, a method where short, high voltage pulses i… |
| ECT | Cemazar et al · Bioelectricity | 2019 | Review | Literature Analysis | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Electrochemotherapy is gaining recognition as an effective local therapy that uses systemically or intratumorally injected bleomycin or cisplatin with electroporation as a delivery system th… |
| Other EP | Nuccitelli · Bioelectricity | 2019 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | This review covers the use of pulsed electric fields in cancer therapy. It is organized into three sections based on pulse length, millisecond domain, microsecond domain, and nanosecond doma… |
| Other EP | Kotnik et al · Annu Rev Biophys | 2019 | Review | Human | Reversible Membrane Permeabilisation, Transmembrane Potential Change | Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient increase in their plasma membrane permeability, allowing transmembrane transport of otherwise … |
| Other EP | Sokołowska et al · Int J Mol Sci | 2019 | Review | Animal (In Vivo) | Electrode Geometry and Placement | The gene delivery to skeletal muscles is a promising strategy for the treatment of both muscular disorders (by silencing or overexpression of specific gene) and systemic secretion of therape… |
| ECT | Esmaeili et al · J Healthc Eng | 2019 | Review | Animal (In Vivo) | Optimisation of Pulse Parameters | The efficiency of electroporation (EP) has made it a widely used therapeutic procedure to transfer cell killing substances effectively to the target site. A lot of researches are being done … |
| IRE | Chen · Technol Cancer Res Treat | 2019 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Irreversible electroporation has raised great interest in the past decade as a means of destroying cancers in a way that does not involve heat. Irreversible electroporation is a novel ablati… |
| Gene ET | Batista Napotnik et al · Bioelectrochemistry | 2018 | Review | Cell Culture | Gene Electrotransfer (Plasmid DNA), Tissue Conductivity and Impedance Change | Exposing cells to an electric field leads to electroporation of the cell membrane which has already been explored and used in a number of applications in medicine and food biotechnology (e.g… |
| ECT | Probst et al · Technol Cancer Res Treat | 2018 | Review | Human | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Electroporation is a well-known phenomenon that occurs at the cell membrane when cells are exposed to high-intensity electric pulses. Depending on electric pulse amplitude and number of puls… |
| Other EP | Shi et al · Molecules | 2018 | Review | Animal (In Vivo) | – | Intracellular delivery is a critical step in biological discoveries and has been widely utilized in biomedical research. A variety of molecular tools have been developed for cell-based gene … |
| IRE | Fuhrmann et al · Technol Cancer Res Treat | 2018 | Review | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | The application of navigational systems has the potential to improve percutaneous interventions. The accuracy of ablation probe placement can be increased and radiation doses reduced. Two di… |
| IRE | Meijerink et al · – | 2018 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Martijn R. Meijerink Hester J. Scheffer Govindarajan Narayanan Editors 123 Irreversible Electroporation in Clinical Practice Martijn R. Meijerink • Hester J. Scheffer Govindarajan Narayanan … |
| Calcium EP | Frandsen et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Calcium Electroporation and ATP Depletion, Increased Intracellular Bleomycin Accumulation | Electrochemotherapy is an anticancer treatment inducing uptake of chemotherapeutics by electroporation. This treatment is increasingly being used clinically and further investigations for im… |
| ECT | Gehl et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | – | Electrochemotherapy has grown out of simple cell experiments through preclinical studies to experimental clinical studies, to an accepted treatment modality for cutaneous metastases for any … |
| ECT | Kranjc et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Radiotherapy is the use of ionizing radiation in the treatment of malignant tumors. It is one of the main treatment modalities for many forms of cancer, with more than half of all cancer pat… |
| IRE | Markelc et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Electroporation/electropermeabilization (EP), achieved by application of electric pulses to cells or tissues, induces reversible permeabilization of cell membranes under suitable conditions,… |
| ECT | Serša et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Vascular Lock Effect, Reversible Membrane Permeabilisation | Electroporation/electropermeabilization (EP), achieved by application of electric pulses to cells or tissues, induces reversible permeabilization of cell membranes under suitable conditions,… |
| ECT | Serša et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Electrochemotherapy is the combination of chemotherapy and local application of electric pulses. Application of electric pulses, i.e., electroporation, is used as a means to increase drug de… |
| Other EP | De Robertis et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Gene Electrotransfer (Plasmid DNA) | Emerging strategies in cancer treatments, such as gene electrotransfer and electrochemotherapy, are very promising. However, preclinical studies of effective therapeutic agents delivered in … |
| ECT | Kamensek et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Systemic / Abscopal Immune Response | Harnessing the body’s own immune system to fight cancer is one of the most encouraging fields of cancer research today. Promising new cancer immunotherapies are currently being tested in precl… |
| ECT | Todorovic et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Potentiation of Cytotoxic Drug Permeability, Interleukin-12 Mediated Immune Stimulation | Electrochemotherapy is a nonthermal tumor ablation modality. The local delivery of electric pulses directly to the tumor transiently increases permeabilization of the cell membrane and signi… |
| IRE | Kos · Handbook of Electroporation | 2017 | Review | Literature Analysis | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | Electrochemotherapy and irreversible electroporation can be used to treat deepseated tumors. Key to treatment success is ensuring that the entirety of the target tumor is covered with electr… |
| IRE | Bhonsle et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) employs a series of brief electric pulses to destabilize cell membranes by altering the transmembrane voltage to create nanoscale defects that induce cell … |
| IRE | Mucciardi et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) and cryoablation (Cryo) are, among the many others in use, respectively, the youngest and the oldest tissue ablation modalities. No other treatment has spr… |
| IRE | Rolong et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The phenomenon of electroporation can be traced back to the eighteenth century when red spots on skin (Lichtenberg figures) were observed in the areas where electric fields were applied. Once … |
| IRE | Thomson et al · Handbook of Electroporation | 2017 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) for focal tumor control has developed since early human studies in 2009 to a point where it is now a useful part of the tumor eradication algorithm. While … |
| IRE | Vroomen et al · Diagn Interv Imaging | 2017 | Review | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Focal treatment with radiofrequency, microwave and cryoablation has been increasingly used for the treatment of tumors in patients who cannot undergo surgical resection and in select patient… |
| ECT | Calvet et al · Cancer Metastasis Rev | 2016 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Potentiation of Cytotoxic Drug Permeability | Anti-tumor electrochemotherapy, which consists in increasing anti-cancer drug uptake by means of electroporation, is now implanted in about 140 cancer treatment centers in Europe. Its use is… |
| Gene ET | Rosazza · Curr Gene Ther | 2016 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Gene electrotransfer is a powerful method of DNA delivery offering several medical applications, among the most promising of which are DNA vaccination and gene therapy for cancer treatment. … |
| IRE | Savic et al · Rofo | 2016 | Review | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Unlabelled: Irreversible electroporation (IRE) is the latest in the series of image-guided locoregional tumor ablation therapies. IRE is performed in a nearly non-thermal fashion that circum… |
| IRE | Wagstaff et al · Onco Targets Ther | 2016 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The field of focal ablative therapy for the treatment of cancer is characterized by abundance of thermal ablative techniques that provide a minimally invasive treatment option in selected tu… |
| Other EP | Lambricht et al · Expert Opin Drug Deliv | 2015 | Review | Human | Gene Electrotransfer (Plasmid DNA), Optimisation of Pulse Parameters | Introduction: Electroporation allows efficient delivery of DNA into cells and tissues, thereby improving the expression of therapeutic or immunogenic proteins that are encoded by plasmid DNA… |
| Other EP | Lee et al · Hum Vaccin Immunother | 2015 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Numerous animal studies and recent clinical studies have shown that electroporation-delivered DNA vaccines can elicit robust Ag-specific CTL responses and reduce disease severity. However, c… |
| IRE | Jiang et al · IEEE Trans Biomed Eng | 2015 | Review | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The use of irreversible electroporation (IRE) for cancer treatment has increased sharply over the past decade. As a nonthermal therapy, IRE offers several potential benefits over other focal… |
| IRE | Narayanan · Semin Intervent Radiol | 2015 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a predominantly nonthermal ablative technology that uses high-voltage, low-energy DC current pulses to induce cell death. Thermal ablative technologies … |
| ECT | Cadossi et al · Future Oncol | 2014 | Review | Human | Systemic / Abscopal Immune Response | Electroporation is used to enhance drug diffusion and gene delivery into the cytosol. The combination of electroporation and cytotoxic drugs, electrochemotherapy (ECT), is used to treat meta… |
| ECT | Miklavčič et al · Biomed Eng Online | 2014 | Review | Human | – | Electrochemotherapy is a local treatment of cancer employing electric pulses to improve transmembrane transfer of cytotoxic drugs. In this paper we discuss electrochemotherapy from the persp… |
| ECT | O’Sullivan · Electroporation-Based Therapies for Cancer | 2014 | Review | Literature Analysis | – | There are so many cancer patients for whom the current standard of cure doesn’t work. Electrochemotherapy could serve as an attractive alternative to many of these patients who have inoperab… |
| ECT | Ramachandran et al · Electroporation-Based Therapies for Cancer | 2014 | Review | Literature Analysis | Optimisation of Pulse Parameters, Increased Intracellular Bleomycin Accumulation | Cancer therapies mainly target the uncontrolled proliferation of the cancerous cells. A translational therapy for inoperable, chemo- and radio-resistant tumors is electroporationbased chemot… |
| Other EP | Yarmush et al · Annu Rev Biomed Eng | 2014 | Review | Animal (In Vivo) | – | When high-amplitude, short-duration pulsed electric fields are applied to cells and tissues, the permeability of the cell membranes and tissue is increased. This increase in permeability is … |
| IRE | Deipolyi et al · Diagn Interv Radiol | 2014 | Review | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in … |
| IRE | Silk et al · Semin Intervent Radiol | 2014 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | A new ablation modality, irreversible electroporation (IRE), has been of increasing interest in interventional radiology. Its nonthermal mechanism of action of killing tumor cells allows phy… |
| Other EP | Geng et al · Lab Chip | 2013 | Review | Animal (In Vivo) | – | Electroporation is a simple yet powerful technique for breaching the cell membrane barrier. The applications of electroporation can be generally divided into two categories: the release of i… |
| Other EP | Aurisicchio et al · Expert Rev Vaccines | 2013 | Review | Human | Gene Electrotransfer (Plasmid DNA) | Therapeutic vaccination could become an important modality to fight cancer. Efficacious immune responses against cancer cells have to be directed simultaneously against multiple epitopes bel… |
| Other EP | Chiarella et al · Curr Drug Metab | 2013 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Since conventional therapeutic approaches in cancer are highly invasive they hardly prolong patient survival for more than few months. Having the ability to stimulate both cellular and humou… |
| IRE | Golberg et al · IEEE Trans Biomed Eng | 2013 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Tissue ablation is an essential procedure for the treatment of many diseases. In the last decade, a nonthermal tissue ablation using intensive pulsed electric fields, called nonthermal irrev… |
| ECT | Miklavčič et al · Med Biol Eng Comput | 2012 | Review | Animal (In Vivo) | Preservation of Extracellular Matrix and Tissue Scaffold, Electric Field Distribution and Modelling | Electrochemotherapy, a combination of high voltage electric pulses and of an anticancer drug, has been demonstrated to be highly effective in treatment of cutaneous and subcutaneous tumors. … |
| ECT | Raeisi · – | 2012 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Biomedical imaging techniques play an important role in all phase of cancer management including detection, screening, biopsy guidance, staging, prognosis, therapy planning, therapy guidance… |
| Other EP | Cha et al · Hum Vaccin Immunother | 2012 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Interleukin-12 Mediated Immune Stimulation | Intratumoral gene electroporation uses electric charges to facilitate entry of plasmid DNA into cells in a reproducible and highly efficient manner, especially to accessible sites such as cu… |
| Other EP | Gothelf et al · Hum Vaccin Immunother | 2012 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Vaccinations are increasingly used to fight infectious disease, and DNA vaccines offer considerable advantages, including broader possibilities for vaccination and lack of need for cold stor… |
| Undetermined | Impellizeri et al · Vet Comp Oncol | 2012 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | The concept of vaccines based on the direct inoculation of plasmid DNA gained initial proof-of-concept in small rodent species. Further development was hampered by the difficulty to confirm … |
| Other EP | Spugnini · BioMed Eng OnLine | 2011 | Review | Literature Analysis | – | This article is a review of the book: Clinical aspects of electroporation, by Stephen T. Kee, Julie Gehl, Edward W Lee, which is published by Springer Press. Basic information that should be… |
| Other EP | Murakami et al · Curr Gene Ther | 2011 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Simple plasmid DNA injection is a safe and feasible gene transfer method, but it confers low transfection efficiency and transgene expression. This non-viral gene transfer method is enhanced… |
| Other EP | Kotnik et al · J Membr Biol | 2010 | Review | Animal (In Vivo) | Transmembrane Potential Change, Reversible Membrane Permeabilisation | Exposure of a cell to an electric field results in inducement of a voltage across its membrane (induced transmembrane voltage, DeltaPsi (m)) and, for sufficiently strong fields, in a transie… |
| Gene ET | Cemazar et al · Curr Gene Ther | 2010 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Interleukin-12 Mediated Immune Stimulation | Electrogene therapy combines administration of plasmid DNA into tissue followed by local application of electric pulses. In electrogene therapy with interleukin-12 (IL-12), different routes … |
| IRE | Lee et al · Gut Liver | 2010 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a novel tumor ablation technique using a non-thermal energy to create innumerable permanent nanopores in the cell membrane to disrupt cellular homeostas… |
| Other EP | Tang et al · Biochem Biophys Res Commun | 2009 | Review | Cell Culture | Apoptosis Induction | Electrical pulses have been widely used in biomedical fields, whose applications depend on the parameters such as durations and electric intensity. Conventional electroporation (0.1-1kV/cm, … |
| Other EP | Villemejane et al · Br J Pharmacol | 2009 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Physical methods of gene (and/or drug) transfer need to combine two effects to deliver the therapeutic material into cells. The physical methods must induce reversible alterations in the pla… |
| ECT | Sadadcharam et al · Int J Hyperthermia | 2008 | Review | Human | Gene Electrotransfer (Plasmid DNA), Electrode Geometry and Placement | Purpose: The aim of this review article is to provide a concise overview of the pre-clinical development of electrochemotherapy (ECT), its present utility in clinical practice and to examine… |
| ECT | Sersa et al · Eur J Surg Oncol | 2008 | Review | Human | Potentiation of Cytotoxic Drug Permeability, Reversible Membrane Permeabilisation | Aim: Electrochemotherapy is a local drug delivery approach aimed at treatment with palliative intent of cutaneous and subcutaneous tumour nodules of different histologies. Electrochemotherap… |
| Other EP | Escoffre et al · Mol Biotechnol | 2008 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | Cell membranes can be transiently permeabilized under application of electric pulses. This treatment allows hydrophilic therapeutic molecules, such as anticancer drugs and DNA, to enter into… |
| Gene ET | Cemazar et al · Curr Opin Mol Ther | 2007 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Electroporation is a physical method for the delivery of various molecules into cells by application of controlled external electrical fields that transiently increase permeability of the ce… |
| IRE | Rubinsky · Technol Cancer Res Treat | 2007 | Review | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | This is a brief introduction to the emerging field of irreversible electroporation in medicine. Certain electrical fields when applied across a cell can have as a sole effect the permeabiliz… |
| Other EP | Prud'homme et al · Curr Gene Ther | 2006 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Nonviral gene transfer is markedly enhanced by the application of in vivo electroporation (also denoted electro-gene transfer or electrokinetic enhancement). This approach is safe and can be… |
| Other EP | Chen et al · Med Biol Eng Comput | 2006 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation | Electroporation, the transient increase in the permeability of cell membranes when exposed to a high electric field, is an established in vitro technique and is used to introduce DNA or othe… |
| Other EP | Phez et al · Biochim Biophys Acta | 2005 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | Electropermeabilization designates the use of electric pulses to overcome the barrier of the cell membrane. This physical method is used to transfer anticancer drugs or genes into living cel… |
| Other EP | Teissie et al · Biochim Biophys Acta | 2005 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | Cell electropulsation is routinely used in cell Biology for protein, RNA or DNA transfer. Its clinical applications are under development for targeted drug delivery and gene therapy. Neverth… |
| ECT | Gothelf et al · Cancer Treat Rev | 2003 | Review | Human | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | Over the last decade a new cancer treatment modality, electrochemotherapy, has emerged. By using short, intense electric pulses that surpass the capacitance of the cell membrane, permeabiliz… |
| ECT | Mir · Bioelectrochemistry | 2001 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation | Cell electropermeabilization (also termed cell electroporation) is nowadays a routine technique used in biochemical and pharmacological studies for the in vitro introduction of nonpermeant m… |
| Other EP | Somiari et al · Mol Ther | 2000 | Review | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Electric Field Distribution and Modelling | Efficient and safe methods for delivering exogenous genetic material into tissues must be developed before the clinical potential of gene therapy will be realized. Recently, in vivo electrop… |
| ECT | Heller et al · Adv Drug Deliv Rev | 1999 | Review | Literature Analysis | Potentiation of Cytotoxic Drug Permeability | Electrochemotherapy is a novel treatment which consists of a combination of a chemotherapeutic agent and pulsed electric fields. This relatively new treatment modality relies on the physical… |
| ECT | Mir et al · Adv Drug Deliv Rev | 1999 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Electrochemotherapy is a new therapeutic approach providing delivery into cell interiors of nonpermeant drugs with intracellular targets. It is based on the local application of short and in… |
| ECT | Neumann et al · Bioelectrochem Bioenerg | 1999 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation, Electric Field Distribution and Modelling | Electrooptical and conductometrical relaxation methods have given a new insight in the molecular mechanisms of the electroporative delivery of drug-like dyes and genes (DNA) to cells and tis… |
| Gene ET | Singh et al · Anticancer Drugs | 1999 | Review | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Gene Electrotransfer (Plasmid DNA) | Tissue electroporation has been explored to enhance the local delivery of chemotherapueutic agents to solid tumors. The technique, known as electrochemotherapy (ECT), uses high-voltage pulse… |
| ECT | Garner et al · IEEE Eng. Med. Biol. Mag. | 1996 | Review | Human | Gene Electrotransfer (Plasmid DNA) | Although electroporation in the past has mainly been used as a research tool, recent work has demonstrated its potential for clinical applications. Some of the areas explored include electro… |
| ECT | Mir et al · Gen Pharmacol | 1996 | Review | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | 1. Bleomycin (BLM) is a cytotoxic drug currently used in anticancer chemotherapy. We present here a summary of the well established "old" knowledge concerning BLM structure, properties and a… |
| ECT | Dev et al · Cancer Treat Rev | 1994 | Review | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Electric Field Distribution and Modelling | A critical review is presented on a novel method of treating cancer by a combination of an electric field with chemotherapeutic agents. The work described here summarizes the current state o… |
| Other EP | Orlowski et al · Biochim Biophys Acta | 1993 | Review | Animal (In Vivo) | Reversible Membrane Permeabilisation | Cell electropermeabilization is the transient permeabilization of the plasma membrane by means of short and intense electric pulses. Under optimized conditions, electropermeabilization is co… |
| Other EP | Arai et al · Gastro Hep Adv | 2026 | Animal Study | Literature Analysis | – | Gastro Hep Advances 2026;5:100916 RESEARCH LETTER ElectroporationInduced Gastric Cancer Models Through EpithelialSpecific Genetic Modifications G astric cancer remains a major global health … |
| Calcium EP | Laursen et al · J Vis Exp | 2026 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Bladder tumors constitute a substantial health challenge, yet advances in the treatment have been few. Electroporation is the use of brief electric pulses that permeabilize cell membranes wi… |
| Other EP | Vargas et al · Res Vet Sci | 2026 | Animal Study | Animal (In Vivo) | Mitochondrial Dysfunction and Oxidative Stress | Introduction: The technique of electroporation is used to facilitate the selective delivery of chemotherapeutic drugs into neoplastic cells, a process known as electrochemotherapy. However, … |
| ECT | Bendix et al · Bioelectrochemistry | 2026 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling | Dendritic cells (DCs) are central to the initiation of anti-tumour immunity, yet the direct effects of electrochemotherapy (ECT) on DC biology remain poorly defined. We investigated how vary… |
| Gene ET | Bozic et al · Biomed Pharmacother | 2026 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | This study investigated the antitumor efficacy of chemokine CCL5 gene therapy using gene electrotransfer (GET) in combination with radiotherapy (RT) in solid murine tumors CT26 and 4T1. In v… |
| Other EP | Grimm et al · Sci Rep | 2026 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Gene Electrotransfer (Plasmid DNA) | Coding nucleic acids (NAs) like DNA, mRNA or siRNA hold endless potential to engineer cells with respect to their genome and proteome. However, minimally invasive delivery of NAs across an i… |
| IRE | Cao et al · bioRxiv | 2026 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Systemic / Abscopal Immune Response | Irreversible electroporation (IRE) has shown promise for treating pancreatic ductal adenocarcinoma (PDAC), but whether IRE can induce an abscopal effect is not established. We demonstrated t… |
| IRE | Liu · Commun Biol | 2026 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Although irreversible electroporation (IRE) is an approved ablation therapy for liver cancer, the border of the IRE-induced inflammatory margin (IM) remains poorly defined, posing a challeng… |
| IRE | Qi et al · Adv Mater | 2026 | Animal Study | Animal (In Vivo) | Mitochondrial Dysfunction and Oxidative Stress, Irreversible Pore Formation and Cell Death | Cancer vaccines face limitations due to the immunosuppressive tumor microenvironment (TME) and the low immunogenicity of tumor antigens. Immunogenic cell death (ICD), triggered by mitochondr… |
| IRE | Sano et al · J Vasc Interv Radiol | 2026 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Purpose: To study the safety and reproducibility of high-voltage integrated nanosecond pulse irreversible electroporation (INSPIRE) administered through a single applicator and grounding pad… |
| IRE | Vista et al · Clin Cancer Res | 2026 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Purpose: One recurring challenge in cell therapy for solid tumors is poor tumor infiltration of adoptively transferred T cells. We previously showed that a subablative dose of tumor-targeted… |
| Other EP | Apollonio et al · Bioelectricity | 2025 | Animal Study | Animal (In Vivo) | – | Francesca Apollonio, PhD,1 James Lyng, PhD,2 Caterina Merla, PhD,3 Lluis Mir, PhD,4 and Emanuela Signori, PhD5 I t is a pleasure to introduce this special issue of Bioelectricity on Recent D… |
| ECT | Bogataj et al · Cancers (Basel) | 2025 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | Background: Electrochemotherapy (ECT) enhances the intracellular delivery of chemotherapeutic agents, most notably bleomycin, through electroporation. Despite high response rates, tumor sens… |
| Other EP | Nafie et al · PLoS One | 2025 | Animal Study | Animal (In Vivo) | – | Aliya®Pulsed Electric Field (PEF) technology is an emerging strategy in the field of cancer treatment, offering a novel approach to ablation therapy that does not rely on thermal mechanisms.… |
| ECT | Radzevičiūtė-Valčiukė et al · Bioelectrochemistry | 2025 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | Electrochemotherapy (ECT) is a cancer treatment approach that utilizes the application of electroporation (EP) with standard chemotherapeutic drugs, resulting in a locally enhanced chemother… |
| ECT | de Caro et al · J Control Release | 2025 | Animal Study | Animal (In Vivo) | Muscle Contraction and Anaesthesia Requirement, Immunogenic Cell Death (ICD) | Electroporation, a physical method that permeabilizes cell membranes, is increasingly used in cancer treatment. By enhancing the uptake of hydrophilic antitumor drugs, it boosts their cytoto… |
| Other EP | Almazloum et al · Med Eng Phys | 2025 | Animal Study | Animal (In Vivo) | – | High-intensity, external electric fields (HIEF) have been used in research and therapy for abnormal generation/propagation of the cardiac electrical activity (e.g., defibrillation), and for … |
| Calcium EP | Hu et al · Small | 2025 | Animal Study | Animal (In Vivo) | Disruption of Calcium Homeostasis, Calcium Electroporation and ATP Depletion | Calcium overload is a promising anticancer treatment that kills tumor cells primarily by causing mitochondrial dysfunction in cells. However, calcium overload therapy is limited by inefficie… |
| Other EP | Szewczyk et al · Bioelectrochemistry | 2025 | Animal Study | Animal (In Vivo) | – | This study explores the combination of jasplakinolide with electroporation (JSP + EP), a method enhancing targeted molecule delivery. CHO-K1 (Chinese hamster ovarian), C2C12 (mouse myoblast)… |
| IRE | Aycock et al · IEEE Trans Biomed Eng | 2025 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a minimally thermal tissue ablation modality used to treat solid tumors adjacent to critical structures. Widespread clinical adoption of IRE has been li… |
| IRE | Esparza · Ann Biomed Eng | 2025 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | High-frequency irreversible electroporation (H-FIRE) is a minimally invasive local ablation therapy known to activate the adaptive immune system and reprogram the tumor microenvironment. Its… |
| IRE | Flak et al · Cancer Treat Res Commun | 2025 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Increased Intracellular Bleomycin Accumulation | Background: Irreversible electroporation (IRE) is a novel anticancer ablative treatment, which has been proposed to enhance the efficacy of chemotherapy in the periphery of the ablated area … |
| IRE | Guo et al · IEEE Trans Biomed Eng | 2025 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | Objective: Irreversible electroporation (IRE) is a non-thermal tissue ablation technique that induces tissue ablation by applying high-voltage pulses through electrodes. In this paper, an im… |
| IRE | Hirata et al · Cardiovasc Intervent Radiol | 2025 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Systemic / Abscopal Immune Response | Purpose: This study aimed to compare systemic immune responses and metastatic effects induced by radiofrequency ablation (RFA) and irreversible electroporation (IRE) in murine tumor models. … |
| IRE | Korganbayev et al · Annu Int Conf IEEE Eng Med Biol Soc | 2025 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) represents a minimally invasive and non-thermal method for tumor ablation, which induces cell death through short high-voltage pulses applied via two needl… |
| IRE | Li et al · Small | 2025 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a minimally invasive, non-thermal tumor ablation technique that induces nanoscale membrane perforation, leading to immunogenic cell death (ICD). However… |
| IRE | Ma et al · World J Gastrointest Oncol | 2025 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Immune Checkpoint Inhibitor Combination | Background: Irreversible electroporation (IRE) is a novel local tumor ablation approach with the potential to activate the host's immune system. However, this approach is insufficient to pre… |
| IRE | Murphy · Cells | 2025 | Animal Study | Animal (In Vivo) | Increased Blood–Brain Barrier Permeability, Reversible Membrane Permeabilisation | High-frequency irreversible electroporation (H-FIRE) is a nonthermal tumor ablation technique that disrupts the blood-brain barrier (BBB) in a focal and reversible manner. However, the mecha… |
| IRE | Nafie · Front Oncol | 2025 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Intoduction: Non-thermal ablation, including irreversible electroporation (IRE) and Aliya®, an advanced biphasic pulsed electric field (aPEF) technology, have emerged as effective tumor abla… |
| IRE | Wang et al · Gene | 2025 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Previous studies have demonstrated that synergistic bipolar irreversible electroporation (SBIRE) is a promising non-thermal tumor ablation technique that effectively targets tumors without c… |
| Other EP | Fesmire et al · IEEE Trans Biomed Eng | 2024 | Animal Study | Animal (In Vivo) | Thermal Effect and Joule Heating, Preservation of Nerve and Vascular Structures | Objective: To study the safety and efficacy of algorithmically controlled electroporation (ACE) against spontaneous equine melanoma. Methods: A custom temperature sensing coaxial electrode w… |
| ECT | Malyško-Ptašinskė et al · Int J Mol Sci | 2024 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | Electroporation-based procedures employing nanosecond bipolar pulses are commonly linked to an undesirable phenomenon known as the cancelation effect. The cancellation effect arises when the… |
| Other EP | Ye et al · Stem Cell Res Ther | 2024 | Animal Study | Animal (In Vivo) | Apoptosis Induction, Increased Intracellular Cisplatin Accumulation | Background: Cisplatin (DDP) is an efficacious and widely applied chemotherapeutic drug for cervical cancer patients who are diagnosed as metastatic and inoperable, or desiring fertility pres… |
| Gene ET | Lampreht · Int J Mol Sci | 2024 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Gene Electrotransfer (Plasmid DNA) | Gene electrotransfer (GET) of plasmids encoding interleukin 12 (IL-12) has already been used for the treatment of various types of tumors in human oncology and as an adjuvant in DNA vaccines… |
| Other EP | Maji · Pharmaceutics | 2024 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Preservation of Extracellular Matrix and Tissue Scaffold | Electroporation (EP) stands out as a promising non-viral plasmid delivery strategy, although achieving optimal transfection efficiency in vivo remains a challenge. A noteworthy advancement i… |
| Other EP | Shi et al · Cancer Immunol Immunother | 2024 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Background: Tumor-reactive T cells play a crucial role in anti-tumor responses, but T cells induced by DNA vaccination are time-consuming processes and exhibit limited anti-tumor efficacy. T… |
| Other EP | Lorenzen et al · J Vis Exp | 2024 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change | Porous substrate electroporation (PSEP) is an emerging method of electroporation that provides high throughput and consistent delivery. Like many other types of intracellular delivery, PSEP … |
| IRE | Jeon · Cancers (Basel) | 2024 | Animal Study | Animal (In Vivo) | Apoptosis Induction, Irreversible Pore Formation and Cell Death | The regulation of apoptosis is the primary goal of ablation therapy. Irreversible electroporation (IRE) is a promising non-thermal tissue ablation-based therapy that induces apoptosis by man… |
| IRE | Jeon et al · Int J Mol Sci | 2024 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a prominent non-thermal ablation method widely employed in clinical settings for the focal ablation therapy of solid tumors. Utilizing high-voltage, sho… |
| IRE | Rajagopalan et al · Bioelectrochemistry | 2024 | Animal Study | Animal (In Vivo) | Mitochondrial Dysfunction and Oxidative Stress, Reversible Membrane Permeabilisation | Membrane permeabilization and thermal injury are the major cause of cell death during irreversible electroporation (IRE) performed using high electric field strength (EFS) and small number o… |
| IRE | Zeng et al · Sci Rep | 2024 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | To evaluate the safety and efficacy of combining EW-7197 with irreversible electroporation (IRE) for improving wound healing, 16 male Sprague-Dawley rats were randomly divided into four grou… |
| ECT | Guedert et al · Bioelectrochemistry | 2023 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Thermal Effect and Joule Heating | Electroporation alters cell membrane structure and tissue electrical properties by short and intense pulsed electric fields (PEF). Static mathematical models are often used to explain the ch… |
| Other EP | Olaiz et al · Cells | 2023 | Animal Study | Animal (In Vivo) | – | Boron neutron capture therapy (BNCT) combines preferential tumor uptake of 10 B compounds and neutron irradiation. Electroporation induces an increase in the permeability of the cell membran… |
| ECT | Radzevičiūtė-Valčiukė et al · Pharmaceuticals (Basel) | 2023 | Animal Study | Animal (In Vivo) | Calcium Electroporation and ATP Depletion, Increased Intracellular Bleomycin Accumulation | Calcium electroporation (CaEP) is an innovative approach to treating cancer, involving the internalization of supraphysiological amounts of calcium through electroporation, which leads to ce… |
| ECT | Raeisi et al · J Shahrekord Univ Med Sci | 2023 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Reversible Membrane Permeabilisation | Background and aims: Electroporation demonstrated certain modulable actions on tumoral cell membrane permeability to increase the intracellular bioavailability of chemotherapeutic drugs. The… |
| ECT | Kesar et al · Vaccines (Basel) | 2023 | Animal Study | Animal (In Vivo) | Immunogenic Cell Death (ICD), Increased Intracellular Bleomycin Accumulation | Electrochemotherapy (ECT) is a clinically acknowledged method that combines the use of anticancer drugs and electrical pulses. Electrochemotherapy with bleomycin (BLM) can induce immunogenic… |
| Gene ET | Komel · Int J Mol Sci | 2023 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Gene Electrotransfer (Plasmid DNA) | Gene immunotherapy has become an important approach in the treatment of cancer. One example is the introduction of genes encoding immunostimulatory cytokines, such as interleukin 2 and inter… |
| IRE | Jacobs et al · Comput Biol Med | 2023 | Animal Study | Animal (In Vivo) | Thermal Effect and Joule Heating, Optimisation of Pulse Parameters | The nonthermal mechanism for irreversible electroporation has been paramount for treating tumors and cardiac tissue in anatomically sensitive areas, where there is concern about damage to ne… |
| IRE | Peng et al · APL Bioeng | 2023 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Precise control of cargo release is essential but still a great challenge for any drug delivery system. Irreversible electroporation (IRE), utilizing short high-voltage pulsed electric field… |
| IRE | Razakamanantsoa et al · Bioelectrochemistry | 2023 | Animal Study | Animal (In Vivo) | Apoptosis Induction, Irreversible Pore Formation and Cell Death | Irreversible electroporation (IRE) has been reported to variably cause apoptosis, necrosis, oncosis or pyroptosis. Intracellular ATP is a key substrate for apoptosis which is rapidly deplete… |
| ECT | Novickij et al · IEEE Trans Biomed Eng | 2022 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Electrode Geometry and Placement | Objective: this work focuses on bleomycin electrochemotherapy using new modality of high repetition frequency unipolar nanosecond pulses. Methods: As a tumor model, Lewis lung carcinoma (LLC… |
| ECT | Radzevičiūtė et al · Bioelectrochemistry | 2022 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Increased Intracellular Bleomycin Accumulation | Electroporation is a pulsed electric field (PEF) induced phenomenon, which effectiveness varies dependent on pulse parameters. This work focuses on nano-electrochemotherapy with bleomycin an… |
| ECT | Balevičiūtė et al · Cancers (Basel) | 2022 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | In this work, a time-dependent and time-independent study on bleomycin-based high-frequency nsECT (3.5 kV/cm × 200 pulses) for the elimination of LLC1 tumours in C57BL/6J mice is performed. … |
| Other EP | Paffenholz et al · Proc Natl Acad Sci U S A | 2022 | Animal Study | Animal (In Vivo) | – | High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to the limited effectiveness of existing chemo- and immunotherapies. To elucidate mechanisms mediating sensi… |
| Calcium EP | Ruzgys · Cancers (Basel) | 2022 | Animal Study | Animal (In Vivo) | Systemic / Abscopal Immune Response, Increased Intracellular Bleomycin Accumulation | Electroporation-based antitumor therapies, including bleomycin electrotransfer, calcium electroporation, and irreversible electroporation, are very effective on directly treated tumors, but … |
| Other EP | Maciulevičius et al · Bioelectrochemistry | 2022 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | Targeted and controlled techniques of intratumoral delivery of chemotherapeutic agents are under extensive development, since they diminish detrimental side-effects of conventional anticance… |
| IRE | Kim · Sci Rep | 2022 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | As a non-thermal ablation method, irreversible electroporation (IRE) has been widely investigated in the treatment of prostate cancer. However, no consensus has been achieved on the optimal … |
| Other EP | Ghorbel et al · Bioelectrochemistry | 2021 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | The use of conductive nanoparticles (NPs) was previously proposed as a way to locally amplify the electric field (EF) intensity at the cell membrane to enhance cell electroporation. To achie… |
| ECT | Navickaitė et al · Bioelectrochemistry | 2021 | Animal Study | Animal (In Vivo) | Disruption of Calcium Homeostasis | The combination of Ca 2+ ions and electroporation has gained attention as potential alternative to electrochemotherapy. Ca 2+ is an important component of the cell membrane repair system and… |
| IRE | Ruzgys · Molecules | 2021 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | One of current applications of electroporation is electrochemotherapy and electroablation for local cancer treatment. Both of these electroporation modalities share some similarities with ra… |
| Gene ET | Kamensek et al · Bioelectrochemistry | 2021 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Gene Electrotransfer (Plasmid DNA) | In situ vaccination is a promising immunotherapeutic approach, where various local ablative therapies are used to induce an immune response against tumor antigens that are released from the … |
| Gene ET | Ursic et al · J Control Release | 2021 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Potentiation of Cytotoxic Drug Permeability | Electrochemotherapy (ECT) exhibits high therapeutic effectiveness in the clinic, achieving up to 80% local tumor control but without a systemic (abscopal) effect. Therefore, we designed a co… |
| ECT | Vižintin et al · Bioelectrochemistry | 2021 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Nanosecond electric pulses have several potential advantages in electroporation-based procedures over the conventional micro- and millisecond pulses including low level of heating, reduced e… |
| Other EP | Wu et al · Proc Natl Acad Sci U S A | 2021 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | Herein, we studied localized electroporation and gene transfection of mammalian cells using a metallodielectric hybrid micromotor that is magnetically and electrically powered. Much like nan… |
| ECT | Cvetković et al · JSSCM | 2021 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | This is a feasibility study for the application of a novel concept of single-needle device for localized chemotherapy. Systemic chemotherapy has numerous and severe side effects. To conduct … |
| Gene ET | Jiang et al · IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc | 2021 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Nonthermal atmospheric pressure plasmas produce reactive plasma species including charged particles and reactive oxygen nitrogen species, which are known to induce oxidative stress in living… |
| IRE | Babikr et al · Cell Mol Immunol | 2021 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a new cancer ablation technology, but methods to improve IRE-induced therapeutic immunity are only beginning to be investigated. We developed a mouse mo… |
| IRE | Beitel-White et al · IEEE Trans Biomed Eng | 2021 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Irreversible Pore Formation and Cell Death | Objective: Tissue electroporation is achieved by applying a series of electric pulses to destabilize cell membranes within the target tissue. The treatment volume is dictated by the electric… |
| IRE | Li et al · Surg Endosc | 2021 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: The aim of this study was to evaluate the feasibility, safety, and efficacy of magnetic anchoring and guidance-assisted endoscopic irreversible electroporation (MAG-IRE) for gast… |
| IRE | Lim · Sci Rep | 2021 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The exposure of the prostate to high electric field strength during irreversible electroporation (IRE) has been extensively investigated. Multiple monopolar electrodes, however, have risks o… |
| IRE | Zhang et al · Int J Hyperthermia | 2021 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Muscle Contraction and Anaesthesia Requirement | Purpose: To examine the ablation zone, muscle contractions, and temperature increases in both rabbit liver and kidney models in vivo for a custom-made high-frequency irreversible electropora… |
| ECT | Azan et al · Sci Rep | 2020 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | The permeabilization of the live cells membrane by the delivery of electric pulses has fundamental interest in medicine, in particular in tumors treatment by electrochemotherapy. Since under… |
| Other EP | Bo et al · Int J Mol Sci | 2020 | Animal Study | Animal (In Vivo) | Nanosecond Pulsed Electric Field (nsPEF), Reversible Membrane Permeabilisation | The principal bioeffect of the nanosecond pulsed electric field (nsPEF) is a lasting cell membrane permeabilization, which is often attributed to the formation of nanometer-sized pores. Such… |
| Gene ET | Dermol-Černe et al · Sci Rep | 2020 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | In gene electrotransfer and cardiac ablation with irreversible electroporation, treated muscle cells are typically of elongated shape and their orientation may vary. Orientation of cells in … |
| ECT | García-Sánchez et al · Bioelectrochemistry | 2020 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | This study presents electrical measurements (both conductivity during the pulses and impedance spectroscopy before and after) performed in liver tissue of mice during electroporation with cl… |
| Other EP | Kim et al · Technol Cancer Res Treat | 2020 | Animal Study | Animal (In Vivo) | Apoptosis Induction, Reversible Membrane Permeabilisation | Tissue electrolysis is an alternative modality that uses a low intensity direct electric current passing through at least 2 electrodes within the tissue and resulting electrochemical product… |
| ECT | Li et al · ACS Appl Mater Interfaces | 2020 | Animal Study | Animal (In Vivo) | Apoptosis Induction, Mitochondrial Dysfunction and Oxidative Stress | Cancer residues around the surgical site remain a significant cause of treatment failure with cancer recurrence. To prevent cancer recurrence and simultaneously repair surgery-caused defects… |
| ECT | Mansourian et al · Electromagn Biol Med | 2020 | Animal Study | Animal (In Vivo) | – | Electrochemotherapy (ECT) is a new and promising treatment strategy for cancer treatment. The aim of this work is to investigate the effect of 900 MHz radiofrequency electromagnetic fields (… |
| ECT | Mansourian et al · Electromagn Biol Med | 2020 | Animal Study | Animal (In Vivo) | – | Electrochemotherapy (ECT), the combination of electric pulses (EPs) and an anticancer drug, is a type of cancer treatment method. We investigated the effect of 217-Hz magnetic fields (MFs) s… |
| Other EP | Miklavcic et al · Bioelectrochemistry | 2020 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Reversible Membrane Permeabilisation | Pulsed electric fields (PEFs) can be used to transiently increase cell membrane permeability in procedures ranging from gene therapy to tumor eradication. Although very efficient, PEF-based … |
| Calcium EP | Novickij · Sci Rep | 2020 | Animal Study | Animal (In Vivo) | Calcium Electroporation and ATP Depletion, Tissue Conductivity and Impedance Change | In the present study, we report the effects of extracellular medium conductivity on cell response in the context of sub-microsecond range (100 ns-900 ns) electroporation, calcium electropora… |
| ECT | Novickij et al · Molecules | 2020 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Tissue Conductivity and Impedance Change | Pulsed electric field (PEF) is frequently used for intertumoral drug delivery resulting in a well-known anticancer treatment-electrochemotherapy. However, electrochemotherapy is associated w… |
| IRE | Polajžer et al · Bioelectrochemistry | 2020 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | It was recently suggested that applying high-frequency short biphasic pulses (HF-IRE) reduces pain and muscle contractions in electrochemotherapy and irreversible ablation treatments; howeve… |
| ECT | Sarnago et al · IEEE Access | 2020 | Animal Study | Animal (In Vivo) | – | Biomedical applications often require high-performance power supplies for diagnosis and treatment systems. In particular, modern electroporation techniques for cancer treatment require high-… |
| Other EP | Zhao et al · Front Bioeng Biotechnol | 2020 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Optimisation of Pulse Parameters | Pulsed electric field treatment modalities typically utilize multiple pulses to permeabilize biological tissue. This electroporation process induces conductivity changes in the tissue, which… |
| IRE | Go et al · Cancers (Basel) | 2020 | Animal Study | Human | Irreversible Pore Formation and Cell Death, Immunogenic Cell Death (ICD) | Recently, cancer immunotherapy has received attention as a viable solution for the treatment of refractory tumors. However, it still has clinical limitations in its treatment efficacy due to… |
| IRE | Merola et al · Biology (Basel) | 2020 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Objective: To test a new bipolar electrode for electroporation consisting of a single minimally invasive needle. Methods: A theoretical study was performed by using Comsol Multiphysics ® sof… |
| IRE | Vižintin et al · Bioelectrochemistry | 2020 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | To achieve high efficiency of electroporation and to minimize unwanted side effects, the electric field parameters must be optimized. Recently, it was suggested that biphasic high-frequency … |
| IRE | Wasson et al · Bioelectrochemistry | 2020 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | High-frequency irreversible electroporation (H-FIRE) is an emerging electroporation-based therapy used to ablate cancerous tissue. Treatment consists of delivering short, bipolar pulses (1-1… |
| IRE | Wood et al · J Surg Res | 2020 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | Background: Nonthermal irreversible electroporation (NTIRE) has been shown to ablate the small intestinal epithelium while maintaining submucosal and muscularis propriae integrity. NTIRE is … |
| Other EP | Dettin et al · Cells | 2019 | Animal Study | Animal (In Vivo) | Preservation of Extracellular Matrix and Tissue Scaffold, Potentiation of Cytotoxic Drug Permeability | Tumor electroporation (EP) refers to the permeabilization of the cell membrane by means of short electric pulses thus allowing the potentiation of chemotherapeutic drugs. Standard plate adhe… |
| ECT | Garabalino et al · Radiat Environ Biophys | 2019 | Animal Study | Animal (In Vivo) | – | Boron neutron capture therapy (BNCT) is a promising cancer binary therapy modality that utilizes the nuclear capture reaction of thermal neutrons by boron-10 resulting in a localized release… |
| Other EP | Ghorbel et al · Nanotechnology | 2019 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Electric Field Distribution and Modelling | Conducive nanoparticles (NPs) were proposed to locally amplify the external electric field (EF) intensity at the cell surface to improve cell electroporation. To better understand the physic… |
| Other EP | Lorenzo et al · Cancers (Basel) | 2019 | Animal Study | Animal (In Vivo) | Increased Blood–Brain Barrier Permeability, Electric Field Distribution and Modelling | Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due to protection from the blood-brain barrier (BBB). Electroporation-based thera… |
| Other EP | Mutsenko et al · Cryobiology | 2019 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters | Cryopreservation is the universal technology used to enable long-term storage and continuous availability of cell stocks and tissues for regenerative medicine demands. The main components of… |
| ECT | Pedersoli et al · Eur Radiol | 2019 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Objectives: We conducted an in vivo trial to investigate the safety and efficacy of a newly developed system for the application of a combined therapy consisting of irreversible electroporat… |
| ECT | Pintarelli et al · Med Eng Phys | 2019 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Increased Intracellular Bleomycin Accumulation | Electrochemotherapy (ECT) exploits the phenomenon of electroporation, which is the increase of cell permeability through the application of an electrical field. This technique is applied in … |
| ECT | Donnelly et al · J Aquat Anim Health | 2019 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Muscle Contraction and Anaesthesia Requirement | Fibropapillomatosis of sea turtles is traditionally treated with surgical debulking techniques that are often associated with prolonged healing and tumor recurrence. Electrochemotherapy was … |
| Other EP | Ruzgys et al · Bioelectrochemistry | 2019 | Animal Study | Animal (In Vivo) | Mitochondrial Dysfunction and Oxidative Stress, Optimisation of Pulse Parameters | Electroporation is a widely-used methodology for permeabilization of cells using pulsed electric field (PEF). In this paper, we compare the electroporation efficiency in terms of molecular t… |
| IRE | López-Alonso et al · Sci Rep | 2019 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) has gained attention as a new non-thermal therapy for ablation with important benefits in terms of homogeneous treatment and fast recovery. In this study, … |
| Calcium EP | Novickij · Cancers (Basel) | 2019 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Calcium Electroporation and ATP Depletion | In this work, we have investigated the feasibility of sub-microsecond range irreversible electroporation (IRE) with and without calcium electroporation in vivo. As a model, BALB/C mice were … |
| IRE | Ringel-Scaia et al · EBioMedicine | 2019 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Background: Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible electroporation (H-FIRE… |
| Other EP | Bhonsle et al · IEEE Trans Biomed Eng | 2018 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Electrode Geometry and Placement | Objective: The use of high-voltage, high-frequency bipolar pulses (HFBPs) is an emerging electroporation-based therapy for the treatment of solid tumors. In this study, we quantify the exten… |
| ECT | Dermol-Černe et al · J Control Release | 2018 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Reversible Membrane Permeabilisation | In electrochemotherapy two conditions have to be met to be successful - the electric field of sufficient amplitude and sufficient uptake of chemotherapeutics in the tumor. Current treatment … |
| Other EP | García-Sánchez et al · Bioelectrochemistry | 2018 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | The effects of pyroelectricity on cell membrane permeability had never been explored. Pyroelectricity consists in the generation of an electric field in the surface of some materials when a … |
| Other EP | García-Sánchez et al · Biochim Biophys Acta Biomembr | 2018 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Tissue Conductivity and Impedance Change | The permeabilization of biological membranes by electric fields, known as electroporation, has been traditionally performed with square electric pulses. These signals distribute the energy a… |
| Other EP | Huang et al · Theranostics | 2018 | Animal Study | Animal (In Vivo) | – | Rationale: Delivery of nucleic acid molecules into skin remains a main obstacle for various types of gene therapy or vaccine applications. Here we propose a novel electroporation approach vi… |
| Other EP | Markelc et al · J Control Release | 2018 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Vascular Lock Effect | Delivery of electric field pulses, i.e. electroporation (EP), to tissues has been shown to have a blood flow modifying effect. Indeed, the diameter of blood vessels exposed to EP is immediat… |
| Calcium EP | Staresinic et al · Sci Rep | 2018 | Animal Study | Animal (In Vivo) | Calcium Electroporation and ATP Depletion, Increased Intracellular Bleomycin Accumulation | Calcium electroporation (CaEP) is a novel anti-tumour treatment that induces cell death by internalization of large quantities of calcium. The anti-tumour effectiveness of CaEP has been demo… |
| Other EP | Cemazar et al · Bioelectrochemistry | 2018 | Animal Study | Animal (In Vivo) | – | Electric field-induced membrane changes are an important approach in the life sciences. However, the developments in knowledge and translational applications face problems of reproducibility… |
| Other EP | Brown et al · Bioelectrochemistry | 2018 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Interleukin-12 Mediated Immune Stimulation | Intratumoral electroporation of plasmid DNA encoding the proinflammatory cytokine interleukin 12 promotes innate and adaptive immune responses correlating with anti-tumor effects. Clinical e… |
| Gene ET | Burkart et al · Gene Ther | 2018 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Gene Electrotransfer (Plasmid DNA) | The use of immunomodulatory cytokines has been shown effective in regressing a wide range of tumors. However, systemic delivery of recombinant cytokines results in serious, potentially life-… |
| Other EP | Cervia et al · Mol Pharm | 2018 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Electrotransfection (ET) is a nonviral method for delivery of various types of molecules into cells both in vitro and in vivo. Close to 90 clinical trials that involve the use of ET have bee… |
| Other EP | Mukhopadhyay et al · Gene Ther | 2018 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Systemic / Abscopal Immune Response | Intratumoral electroporation-mediated IL-12 gene therapy (IT-pIL12/EP) has been shown to be safe and effective in clinical trials, demonstrating systemic antitumor effects with local deliver… |
| ECT | Tremble et al · Cancer Lett | 2018 | Animal Study | Animal (In Vivo) | Immunogenic Cell Death (ICD) | Electrochemotherapy is an evolving therapy which has recently been shown to induce an immunogenic form of cell death. It is hypothesized that the immunogenic cell death induced by electroche… |
| Other EP | Dermol-Cerne et al · IEEE Trans Biomed Eng | 2018 | Animal Study | Animal (In Vivo) | – | Current models of tissue electroporation either describe tissue with its bulk properties or include cell level properties, but model only a few cells of simple shapes in low-volume fractions… |
| Undetermined | Mi et al · Technol Cancer Res Treat | 2018 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Muscle Contraction and Anaesthesia Requirement | We studied the influence of various parameters of high-frequency nanosecond pulse bursts on the strength of rabbit muscle contractions. Ten unipolar high-frequency pulse bursts with various … |
| IRE | O’Brien et al · Int J Hyperthermia | 2018 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Purpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and tempera… |
| IRE | Sano et al · J Vasc Interv Radiol | 2018 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Muscle Contraction and Anaesthesia Requirement | Purpose: To compare the intensity of muscle contractions in irreversible electroporation (IRE) treatments when traditional IRE and high-frequency IRE (H-FIRE) waveforms are used in combinati… |
| IRE | Tian et al · Drug Deliv | 2018 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is an emerging minimally invasive tumor ablation technique that delivers short pulses of strong electric fields and kills cancer cells by disrupting their … |
| Other EP | Caprettini et al · Sci Rep | 2017 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability | Electroporation of in-vitro cultured cells is widely used in biological and medical areas to deliver molecules of interest inside cells. Since very high electric fields are required to elect… |
| Other EP | Ciobanu et al · J Membr Biol | 2017 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | Electric pulses, when applied to a cell suspension, induce a reversible permeabilization of the plasma membrane. This permeabilized state is a long-lived process (minutes). The biophysical m… |
| Other EP | Hanna et al · Sci Rep | 2017 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Nanosecond Pulsed Electric Field (nsPEF) | Microsecond pulsed electric fields (μsPEF) permeabilize the plasma membrane (PM) and are widely used in research, medicine and biotechnology. For internal membranes permeabilization, nanosec… |
| Other EP | Zhang et al · Am J Physiol Lung Cell Mol Physiol | 2017 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability | Exosomes are nanovesicles secreted by cells and contain various molecules including protein, lipid, and DNA/RNA. They are crucial mediators of the intercellular communication and serve as pr… |
| Calcium EP | Frandsen et al · Cancer Res | 2017 | Animal Study | Animal (In Vivo) | Calcium Electroporation and ATP Depletion, Necrosis and Necroptosis | Calcium electroporation may offer a simple general tool for anticancer therapy. Transient permeabilization of cancer cell membranes created by applying short, high-voltage pulses in tumors e… |
| Gene ET | Kamensek et al · Plasmid | 2017 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Gene Electrotransfer (Plasmid DNA) | Electrotransfer mediated delivery of interleukin-12 (IL-12) gene, encoded on a plasmid vector, has already been demonstrated to have a potent antitumor efficacy and great potential for clini… |
| Gene ET | Kos et al · Bioelectrochemistry | 2017 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Electrode Geometry and Placement | Skin is an attractive target for gene electrotransfer due to its easy accessibility and its interesting immune properties. Since electrodes are often invasive and frequently induce discomfor… |
| Other EP | Liu et al · Protein Cell | 2017 | Animal Study | Animal (In Vivo) | – | The generation of T cells with maximal anti-tumor activities will significantly impact the field of T-cell-based adoptive immunotherapy. In this report, we found that OKT3/IL-2-stimulated T … |
| Other EP | Sales et al · Vaccine | 2017 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | In vivo electroporation (EP) has reignited the clinical interest on DNA vaccines as immunotherapeutic approaches to control different types of cancer. EP has been associated with increased i… |
| IRE | Wang · Oncol Lett | 2017 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a physical, non-thermal cancer therapy, which leads to cell death via permanent membrane permeability. This differs from reversible electroporation (RE)… |
| IRE | Chai et al · Biomed Microdevices | 2017 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The aim of this study was to evaluate the effects of irreversible electroporation (IRE) on the eradication of rabbit VX2 cervical tumors. A VX2 cervical cancer model was first made in 20 New… |
| IRE | Kranjc · Sci Rep | 2017 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is gaining importance in routine clinical practice for nonthermal ablation of solid tumors. For its success, it is extremely important that the coverage an… |
| IRE | Li et al · Exp Ther Med | 2017 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The aim of the present study was to evaluate the effects of irreversible electroporation (IRE) on the stomach wall following the direct application of IRE onto the organ surface. IRE ablatio… |
| IRE | Srimathveeravalli et al · J Vasc Interv Radiol | 2017 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Purpose: To evaluate the effect of catheter-directed irreversible electroporation (IRE) on the integrity, patency, and function of the normal porcine ureter. Materials and methods: A cathete… |
| IRE | Yao · Sci Rep | 2017 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) uses ~100 μs pulsed electric fields to disrupt cell membranes for solid tumor ablation. Although IRE has achieved exciting preliminary clinical results, im… |
| Other EP | Dermol et al · PLoS One | 2016 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Electroporation-induced cell sensitization was described as the occurrence of a delayed hypersensitivity to electric pulses caused by pretreating cells with electric pulses. It was achieved … |
| ECT | Maglietti et al · Radiol Oncol | 2016 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | Background: Electrochemotherapy (ECT), a medical treatment widely used in human patients for tumor treatment, increases bleomycin toxicity by 1000 fold in the treated area with an objective … |
| Other EP | Silve et al · Sci Rep | 2016 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | The impact of external medium conductivity on the efficiency of the reversible permeabilisation caused by pulsed electric fields was investigated. Pulses of 12 ns, 102 ns or 100 μs were inve… |
| Other EP | Sweeney et al · Biochim Biophys Acta | 2016 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | High-frequency bipolar electric pulses have been shown to mitigate undesirable muscle contraction during irreversible electroporation (IRE) therapy. Here, we evaluate the potential applicabi… |
| Gene ET | Stimac et al · Cancer Gene Ther | 2016 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Apoptosis Induction | Gene electrotransfer of plasmid encoding shRNA against endoglin exerts antitumor efficacy, predominantly by vascular targeted effect. As vascular targeting therapies can promote radiosensiti… |
| Other EP | Znidar et al · Mol Ther Nucleic Acids | 2016 | Animal Study | Animal (In Vivo) | Necrosis and Necroptosis, Gene Electrotransfer (Plasmid DNA) | In several preclinical tumor models, antitumor effects occur after intratumoral electroporation, also known as electrotransfer, of plasmid DNA devoid of a therapeutic gene. In mouse melanoma… |
| IRE | Wandel et al · J Vasc Interv Radiol | 2016 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Purpose: To optimize single-insertion bipolar irreversible electroporation (IRE) by characterizing effects of electric parameters and controlling tissue electric properties in a porcine mode… |
| IRE | Lin et al · Ultrasound Med Biol | 2016 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The objective of this study was to describe the performance of ultrasound (US) and contrast-enhanced ultrasound (CEUS) within 2 h after irreversible electroporation (IRE) ablation of porcine… |
| Other EP | Demiryurek et al · Biochim Biophys Acta | 2015 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | Electroporation is of interest for many drug-delivery and gene-therapy applications. Prior studies have shown that a two-pulse-electroporation protocol consisting of a short-duration, high-v… |
| Gene ET | Dolinsek et al · Curr Gene Ther | 2015 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Antivascular Effect and Vessel Disruption | New targets and therapeutic approaches for vascular targeted strategies in oncology are continuously explored. Endoglin, a co-receptor of TGF-β, is a known target, however, its silencing wit… |
| Other EP | Mahmood et al · Acta Oncol | 2015 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | Background: Tissue permeabilization by electroporation (EP) is a promising technique to treat certain cancers. Non-invasive methods for verification of induced permeabilization are important… |
| Other EP | Pavšelj et al · J Biomech Eng | 2015 | Animal Study | Animal (In Vivo) | – | In this paper, we discuss some of the primary experimental factors that should be considered when interpreting and implementing the published results of skin electroporation studies concerni… |
| Other EP | Semenov et al · Biochim Biophys Acta | 2015 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | Ca2+ activation and membrane electroporation by 10-ns and 4-ms electric pulses (nsEP and msEP) were compared in rat embryonic cardiomyocytes. The lowest electric field which triggered Ca2+ t… |
| Gene ET | Trainito et al · Electrophoresis | 2015 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | The electric field is commonly used in microdevices to handle, treat, or monitor living cells for various biological or biomedical applications (cells electrofusion, gene electrotransfer, dr… |
| Other EP | Wegner et al · Biophys J | 2015 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Electric Field Distribution and Modelling | Treatment of biological material by pulsed electric fields is a versatile technique in biotechnology and biomedicine used, for example, in delivering DNA into cells (transfection), ablation … |
| Other EP | Zorec et al · Int J Pharm | 2015 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability | In our present study we focus on two physical enhancement methods for transdermal drug delivery: ultrasound and electric pulses either alone or in combination. Great emphasis has been given … |
| Other EP | Amante et al · Hum Gene Ther Methods | 2015 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | The CELLECTRA-3P dermal electroporation device (Inovio Pharmaceuticals, Plymouth Meeting, PA) has been evaluated in the clinic and shown to enhance the delivery of an influenza DNA vaccine. … |
| Other EP | Brolin et al · Mol Ther Nucleic Acids | 2015 | Animal Study | Animal (In Vivo) | – | Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting f… |
| Gene ET | Heller et al · Adv Genet | 2015 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Plasmid or non-viral gene therapy offers an alternative to classic viral gene delivery that negates the need for a biological vector. In this case, delivery is enhanced by a variety of appro… |
| Other EP | Lamolinara et al · J Immunol Res | 2015 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Potentiation of Cytotoxic Drug Permeability | Skin represents an attractive target for DNA vaccine delivery because of its natural richness in APCs, whose targeting may potentiate the effect of vaccination. Nevertheless, intramuscular e… |
| Gene ET | Markelc et al · Bioelectrochemistry | 2015 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Application of electric pulses (electroporation/electropermeabilization) is an effective method for gene transfer (i.e. gene electrotransfer (GET)) in vitro and in vivo. Currently, the mecha… |
| Gene ET | Pavlin et al · Sci Rep | 2015 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Gene electrotransfer is a promising non-viral method of gene delivery. In our in vitro study we addressed open questions about this multistep process: how electropermeabilization is related … |
| Other EP | Thalmensi et al · Oncoimmunology | 2015 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Human telomerase reverse transcriptase (hTERT) is overexpressed in more than 85% of human cancers regardless of their cellular origin. As immunological tolerance to hTERT can be overcome not… |
| Other EP | García-Sánchez et al · Bioelectrochemistry | 2015 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Optimisation of Pulse Parameters | In this study, electrical impedance spectroscopy measurements are performed during electroporation of monolayers of differentiated myotubes. The time resolution of the system (1 spectrum/ms)… |
| Other EP | Kranjc et al · Radiology | 2015 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Purpose: To investigate the feasibility of magnetic resonance (MR) electric impedance tomography ( EIT electric impedance tomography ) technique for in situ monitoring of electric field dist… |
| Other EP | Marčan et al · Biomed Eng Online | 2015 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling | Background: Treatments based on electroporation are a new and promising approach to treating tumors, especially non-resectable ones. The success of the treatment is, however, heavily depende… |
| Other EP | Xu et al · Bioelectrochemistry | 2015 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Electroporation is a commonly used approach to rapidly introduce exogenous molecules into cells without permanent damage. Compared to classical electroporation protocols, microchip-based ele… |
| IRE | Golberg et al · Sci Rep | 2015 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | Irreversible electroporation (IRE) is an emerging, minimally invasive technique for solid tumors ablation, under clinical investigation for cancer therapy. IRE affects only the cell membrane… |
| IRE | Serša · Biomed Eng Online | 2015 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | Background: Electroporation is gaining its importance in everyday clinical practice of cancer treatment. For its success it is extremely important that coverage of the target tissue, i.e. tr… |
| ECT | Hudej et al · J Membr Biol | 2014 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Potentiation of Cytotoxic Drug Permeability | To increase electrochemotherapy (ECT) applicability, the effectiveness of new drugs is being tested in combination with electroporation. Among them two ruthenium(III) compounds, (imH)[trans-… |
| ECT | Spugnini et al · J Cell Physiol | 2014 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters | Electrochemotherapy (ECT) is a cancer therapy that conjugates the administration of a chemotherapy agent to the delivery of permeabilizing pulses released singularly or as bursts. This appro… |
| Gene ET | Calvet · Mol Ther Methods Clin Dev | 2014 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | DNA vaccination consists in administering an antigen-encoding plasmid in order to trigger a specific immune response. This specific vaccine strategy is of particular interest to fight agains… |
| Other EP | Calvet et al · Oncoimmunology | 2014 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | DNA vaccination consists of administering an antigen-coding nucleotide sequence. In order to improve the efficacy of DNA vaccines, electroporation is one of the most commonly used methods to… |
| Other EP | Pinyon et al · Sci Transl Med | 2014 | Animal Study | Animal (In Vivo) | Electrode Geometry and Placement | The cochlear implant is the most successful bionic prosthesis and has transformed the lives of people with profound hearing loss. However, the performance of the "bionic ear" is still largel… |
| Gene ET | Todorovic et al · Bioelectrochemistry | 2014 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Optimisation of Pulse Parameters | Gene electrotransfer is an established method for plasmid delivery into different tissues. Contrary to extensive in vitro studies demonstrating increased gene electrotransfer by changing the… |
| Other EP | Kranjc et al · Physiol Meas | 2014 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change | The electroporation effect on tissue can be assessed by measurement of electrical properties of the tissue undergoing electroporation. The most prominent techniques for measuring electrical … |
| Undetermined | Aurisicchio et al · Oncoimmunology | 2014 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Genetic vaccines are emerging as a powerful modality to induce T-cell responses to target tumor associated antigens (TAA). Viral or plasmid DNA or RNA vectors harbor an expression cassette e… |
| Other EP | Grys · Cell Mol Biol Lett | 2014 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | The recently described method of cell electroporation by flow of cell suspension through localized direct current electric fields (dcEFs) was applied to identify non-toxic substances that co… |
| IRE | Sano et al · Bioelectrochemistry | 2014 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | Under the influence of external electric fields, cells experience a rapid potential buildup across the cell membrane. Above a critical threshold of electric field strength, permanent cell da… |
| Other EP | Blagus et al · J Control Release | 2013 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Optimisation of Pulse Parameters | Electroporation (EP) is a physical method for the delivery of molecules into cells and tissues, including the skin. In this study, in order to control the degree of transdermal and topical d… |
| Other EP | Chopinet et al · Biochim Biophys Acta | 2013 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | Electropermeabilization is a physical method that uses electric field pulses to deliver molecules into cells and tissues. Despite its increasing interest in clinics, little is known about pl… |
| ECT | Markelc et al · PLoS One | 2013 | Animal Study | Animal (In Vivo) | Vascular Lock Effect, Antivascular Effect and Vessel Disruption | Electropermeabilization/electroporation (EP) provides a tool for the introduction of molecules into cells and tissues. In electrochemotherapy (ECT), cytotoxic drugs are introduced into cells… |
| ECT | Pakhomova et al · J Cell Mol Med | 2013 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | Cell permeabilization by electric pulses (EP), or electroporation, is widely used for intracellular delivery of drugs and plasmids, as well as for tumour and tissue ablation. We found that c… |
| Other EP | Wu et al · Sci Rep | 2013 | Animal Study | Animal (In Vivo) | – | We present a multi-functional electroporation method for delivery of biomolecule utilizing a high-density distributed electrode network (HDEN) under tri-phase electric stimulation. The HDEN … |
| Other EP | Yun et al · Lab Chip | 2013 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling | We developed an on-chip microscale electroporation system that enables sequential delivery of multiple molecules with precise and independent dosage controllability into pre-selected identic… |
| Other EP | Zorec et al · Int J Pharm | 2013 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability | Electroporation can be used as an active enhancement method for intra- and transdermal drug delivery. Differences in response of skin to electric pulses depend on their amplitude, duration a… |
| Other EP | Baldi · Front Biosci (Elite Ed) | 2013 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation | There is not a consensus on the best therapeutic approach to mesothelioma and the prognosis is still dismal. We have recently demonstrated that HtrA1 is a potential therapeutic target in mes… |
| Gene ET | Kamensek · Mol Cancer | 2013 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Gene Electrotransfer (Plasmid DNA) | Background: Radiation induced transcriptional targeting is a gene therapy approach that takes advantage of the targeting abilities of radiotherapy by using radio inducible promoters to spati… |
| Other EP | Rosazza et al · Mol Ther | 2013 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Electroporation is a physical method of transferring molecules into cells and tissues. It takes advantage of the transient permeabilization of the cell membrane induced by electric field pul… |
| IRE | Ben-David et al · Radiology | 2013 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Purpose: To study the effects of the surrounding electrical microenvironment and local tissue parameters on the electrical parameters and outcome of irreversible electroporation (IRE) ablati… |
| IRE | Faroja et al · Radiology | 2013 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Purpose: To determine whether high-dose irreversible electroporation (IRE) ablation induces thermal effects in normal liver tissue. Materials and methods: Animal care and use committee appro… |
| IRE | Hjouj et al · Sci Rep | 2013 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | To generate an understanding of the physiological significance of MR images of Non-Thermal Irreversible Electroporation (NTIRE) we compared the following MR imaging sequences: T1W, T2W, PD, … |
| IRE | Kim et al · Biochem Biophys Res Commun | 2013 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Apoptosis Induction | Irreversible electroporation is a novel method of ablating living tissues through its non-thermal effects, unlike radiofrequency ablation which has a severe problem of heat sink. It is due t… |
| IRE | Neal et al · PLoS One | 2013 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a non-thermal focal ablation technique that uses a series of brief but intense electric pulses delivered into a targeted region of tissue, killing the c… |
| IRE | Sommer et al · J Vasc Interv Radiol | 2013 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Purpose: To analyze irreversible electroporation (IRE) of the pig kidney with involvement of the renal pelvis. Materials and methods: IRE of renal tissue including the pelvis was performed i… |
| Other EP | Trujillo et al · Int J Hyperthermia | 2013 | Animal Study | Animal (In Vivo) | Thermal Effect and Joule Heating | Purpose: The aim of this study was to assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA)… |
| ECT | Bellard et al · J Control Release | 2012 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Vascular Lock Effect | Electroporation/electropermeabilization, i.e. the result of the application of electric pulses to tissues, is a physical method for delivery of exogenous molecules into cells. It is effectiv… |
| ECT | Calmels et al · Technol Cancer Res Treat | 2012 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Increased Intracellular Bleomycin Accumulation | In vivo cell electropermeabilization can be used alone or in combination with a hydrophilic, nonpermeant cytotoxic drug such as bleomycin (electrochemotherapy) to efficiently treat tumors. W… |
| Calcium EP | Frandsen et al · Cancer Res | 2012 | Animal Study | Animal (In Vivo) | Calcium Electroporation and ATP Depletion, Necrosis and Necroptosis | Electroporation of cells with short, high-voltage pulses causes a transient permeabilization of cell membranes that permits passage of otherwise nonpermeating ions and molecules. In this stu… |
| Other EP | Markelc et al · J Membr Biol | 2012 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Electropermeabilization/electroporation (EP) is a physical method that by application of electric pulses to cells increases cell membrane permeability and enables the introduction of molecul… |
| Other EP | Meschini et al · Eur J Cancer | 2012 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | Few articles in the literature have focused on electroporation as a strategy to reverse multidrug resistance (MDR) of tumour cells and they are mostly limited to the improved efficacy of ble… |
| ECT | Mozdarani et al · Cell J | 2012 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Increased Intracellular Bleomycin Accumulation | Objective: In electrochemotherapy (ECT), there is an unpleasant sensation of muscle contraction when using a low frequency (1 Hz). Therefore, by increasing the pulse frequency above the teta… |
| ECT | Pelofy et al · J Membr Biol | 2012 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | Despite great potential for disease treatment, small interfering RNA (siRNA) development has been hampered due to its poor stability and the lack of efficient delivery method. To overcome th… |
| Other EP | Van Lint et al · Cancer Res | 2012 | Animal Study | Animal (In Vivo) | – | The use of tumor-associated antigen (TAA) mRNA for therapeutic purposes is under active investigation. To be effective, mRNA vaccines need to deliver activation stimuli in addition to TAAs t… |
| Other EP | Arigoni et al · Angiogenesis | 2012 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Necrosis and Necroptosis | Angiomotin (Amot) is one of several identified angiostatin receptors expressed by the endothelia of angiogenic tissues. We have shown that a DNA vaccine targeting Amot overcome immune tolera… |
| Gene ET | Cemazar et al · Hum Gene Ther | 2012 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Preservation of Extracellular Matrix and Tissue Scaffold | One of the applications of electroporation/electropulsation in biomedicine is gene electrotransfer, the wider use of which is hindered by low transfection efficiency in vivo compared with vi… |
| Other EP | Chabot et al · Gene Ther | 2012 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | A major issue for successful human gene therapy or genetic vaccination is a safe high-transgene expression level. Plasmid-based (non-viral) physical methods of gene transfer offered attracti… |
| Other EP | Choi et al · Small | 2012 | Animal Study | Animal (In Vivo) | Electrode Geometry and Placement, Gene Electrotransfer (Plasmid DNA) | The impact of many biopharmaceuticals, including protein- and gene-based therapies, has been limited by the need for better methods of delivery into cells within tissues. Here, intracellular… |
| Other EP | Kardos et al · Hum Vaccin Immunother | 2012 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Electroporation, an attractive process for delivering DNA and other molecules into target cells in vivo and in vitro is limited by the necessity of electrodes that need to be in contact with… |
| Other EP | Lin et al · Hum Gene Ther Methods | 2012 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | In vivo electroporation (EP) is an efficient nonviral method for enhancing DNA vaccine delivery and immunogenicity in animals and humans. Intradermal delivery of DNA vaccines is an attractiv… |
| Gene ET | Rosazza et al · Int J Pharm | 2012 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | The delivery of therapeutic molecules such as plasmid DNA in cells and tissues by means of electric fields holds great promise for anticancer treatment. To allow for their therapeutic action… |
| Other EP | García-Sánchez et al · J Membr Biol | 2012 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | In situ electroporation of adherent cells provides significant advantages with respect to electroporation systems for suspension cells, such as causing minimal stress to cultured cells and s… |
| IRE | Garcia et al · PLoS One | 2012 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Increased Blood–Brain Barrier Permeability | The blood-brain-barrier (BBB) presents a significant obstacle to the delivery of systemically administered chemotherapeutics for the treatment of brain cancer. Irreversible electroporation (… |
| IRE | LIU et al · Oncol Lett | 2012 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a new tumor ablation technique. Pulsed electric fields (PEFs) with permanent duration (100 μsec) permanently permeabilize the cell membrane, causing the… |
| IRE | Phillips et al · Br J Cancer | 2012 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Background: Non-thermal irreversible electroporation (NTIRE) has recently been conceived as a new minimally invasive ablation method, using microsecond electric fields to produce nanoscale d… |
| IRE | Schoellnast et al · Eur Radiol | 2012 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Objective: To evaluate the delayed effects of irreversible electroporation (IRE) ablation on nerves. Methods: The study was approved by the institutional animal care and use committee. CT-gu… |
| Other EP | Diao · World J Gastroenterol | 2011 | Animal Study | Animal (In Vivo) | Necrosis and Necroptosis, Haemostasis and Bleeding Control | Aim: To investigate the effect of transgenic expression of kallistatin (Kal) on carbon tetrachloride (CCl(4))-induced liver injury by intramuscular (im) electrotransfer of a Kal-encoding pla… |
| ECT | Shankayi et al · J Membr Biol | 2011 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Increased Intracellular Bleomycin Accumulation | The most important unpleasant sensation of electrochemotherapy is muscle contraction. One of the causes of this discomfort is electrochemotherapy in the low-frequency range (1 Hz). To resolv… |
| Undetermined | Vittorio et al · Nanotechnology | 2011 | Animal Study | Animal (In Vivo) | – | In this study we investigate the potential of multiwall carbon nanotubes (MWCNTs) with low metal impurities (2.57% iron) as magnetic resonance imaging (MRI) contrast agents. Taking into acco… |
| Other EP | Badea et al · DDL | 2011 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Gemini surfactant-lipid cationic nanoparticles (NP) and electroporation (EP) with a novel tape-electrode were evaluated in mice as topical delivery methods for plasmid DNA encoding luciferas… |
| Other EP | Donate et al · PLoS One | 2011 | Animal Study | Animal (In Vivo) | Electrode Geometry and Placement | Current progress in the development of vaccines has decreased the incidence of fatal and non-fatal infections and increased longevity. However, new technologies need to be developed to comba… |
| Gene ET | Guo et al · J Control Release | 2011 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Electrode Geometry and Placement | Because of its large surface area and easy access for both delivery and monitoring, the skin is an attractive target for gene therapy for cutaneous diseases, vaccinations and several metabol… |
| Gene ET | Hojman et al · Hum Gene Ther | 2011 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Gene electrotransfer is expanding in clinical use, thus we have searched for an emergency procedure to stop transgene expression in case of serious adverse events. Calcium is cytotoxic at hi… |
| Other EP | Lin et al · Vaccine | 2011 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Electroporation (EP) of either muscle or skin has proven to be an efficient method for increasing DNA-based vaccine delivery and immunogenicity in small and large animals. Previous comparati… |
| Gene ET | Markelc et al · Gene Ther | 2011 | Animal Study | Animal (In Vivo) | Mitochondrial Dysfunction and Oxidative Stress, Gene Electrotransfer (Plasmid DNA) | Electropermeabilization (EP) is an effective method of gene transfer into different tissues. During EP, reactive oxygen species (ROS) are formed, which could affect transfection efficiency. … |
| Other EP | Paganin-Gioanni et al · Proc Natl Acad Sci U S A | 2011 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | The RNA interference-mediated gene silencing approach is promising for therapies based on the targeted inhibition of disease-relevant genes. Electropermeabilization is one of the nonviral me… |
| Gene ET | Rosazza et al · Mol Ther | 2011 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Electrotransfer of molecules is a well established technique which finds extensive use for gene transfer and holds great promise for anticancer treatment. Despite its widespread application,… |
| Other EP | Pucihar et al · IEEE Trans Biomed Eng | 2011 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | Electroporation-based applications require the use of specific pulse parameters for a successful outcome. When recommended values of pulse parameters cannot be set, similar outcomes can be o… |
| IRE | Golberg et al · Phys Med Biol | 2011 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | Non-thermal irreversible electroporation (NTIRE) is a biophysical phenomenon which involves application of electric field pulses to cells or tissues, causing certain rearrangements in the me… |
| IRE | Li et al · PLoS One | 2011 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: If a critical nerve is circumferentially involved with tumor, radical surgery intended to cure the cancer must sacrifice the nerve. Loss of critical nerves may lead to serious co… |
| ECT | Sersa et al · J Membr Biol | 2010 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Increased Intracellular Bleomycin Accumulation | Electrochemotherapy is an efficient local treatment of tumors that combines administration of a chemotherapeutic drug with the subsequent application of electric pulses to the tumor. Althoug… |
| ECT | Fantozzi et al · Bioelectrochemistry | 2010 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Electric Field Distribution and Modelling | The achievement of electrochemotherapy was obtained using electrodes covered with guar gum (GG) hydrogel swollen in a sulfate bleomycin solution. The bleomycin delivery into the plasma membr… |
| Other EP | Napotnik et al · Med Biol Eng Comput | 2010 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | It has been reported previously that electric pulses of sufficiently high voltage and short duration can permeabilize the membranes of various organelles inside living cells. In this article… |
| Other EP | Anon · Molecular Therapy | 2010 | Animal Study | Animal (In Vivo) | – | This publication has no abstract. |
| Other EP | Anon · Molecular Therapy | 2010 | Animal Study | Animal (In Vivo) | Electrode Geometry and Placement | DNA electrotransfer to muscle tissue yields high-level, long-term expression of the transferred products. This is advantageous in many treatment regiments, but also poses a concern of how to… |
| Other EP | Anon · Molecular Therapy | 2010 | Animal Study | Animal (In Vivo) | – | This publication has no abstract. |
| Other EP | Anon · Molecular Therapy | 2010 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | NA Vaccine Delivery to Both Skin and Muscle Feng Lin,1 Jay McCoy,1 Xuefei Shen,1 Janess Mendoza,1 Kate E. Broderick,1 Jian Yan,3 Steve Kemmerrer,1 David B. Weiner,3 Niranjan Y. Sardesai.2 1 … |
| Other EP | Broderick et al · Gene Ther | 2010 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Electrode Geometry and Placement | The magnitude of the immune response to a DNA vaccine depends on three criteria--the optimized vector design, the use of a suitable adjuvant and the successful delivery and subsequent expres… |
| Other EP | Daugimont et al · J Membr Biol | 2010 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability | The association of microneedles with electric pulses causing electroporation could result in an efficient and less painful delivery of drugs and DNA into the skin. Hollow conductive micronee… |
| Gene ET | Gothelf et al · Gene Ther | 2010 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Electrode Geometry and Placement | Gene electrotransfer refers to gene transfection by electroporation and is an effective non-viral method for delivering naked DNA into cells and tissues. This study presents data from gene e… |
| ECT | Traitcheva et al · Bioelectrochemistry | 2010 | Animal Study | Animal (In Vivo) | Apoptosis Induction, Potentiation of Cytotoxic Drug Permeability | In order to increase the permeability of cell membranes for low doses of cytostatic drugs, two bioelectrochemical methods have been compared: (a) electric pore formation in the plasma membra… |
| Gene ET | Vidic et al · Cancer Gene Ther | 2010 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Mutations of K-ras have been found in 30-60% of colorectal carcinomas and are believed to be associated with tumor initiation, tumor progression and metastasis formation. Therefore, silencin… |
| Other EP | Anon · Molecular Therapy | 2010 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change | This publication has no abstract. |
| IRE | Garcia et al · J Membr Biol | 2010 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive technique to treat cancer. It is unique because of its nonthermal mechanism of tumor ablation. Intracranial NTIRE … |
| ECT | Cör et al · Radiology and Oncology | 2009 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Optimisation of Pulse Parameters | Comparison between hypoxic markers pimonidazole and glucose transporter 1 (Glut-1) in murine fibrosarcoma tumours after electrochemotherapyBackground. Tumour hypoxia occurs as a result of an… |
| Gene ET | Hojman et al · PLoS One | 2009 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Erythropoietin can be over-expressed in skeletal muscles by gene electrotransfer, resulting in 100-fold increase in serum EPO and significant increases in haemoglobin levels. Earlier studies… |
| Other EP | Ivorra et al · Phys Med Biol | 2009 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | Electroporation is the phenomenon in which cell membrane permeability is increased by exposing the cell to short high-electric-field pulses. Reversible electroporation treatments are used in… |
| ECT | Kranjc et al · Radiat Res | 2009 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | Electrochemotherapy can potentiate the radiosensitizing effect of bleomycin, as shown in our previous studies. To bring this treatment closer to use in clinical practice, we evaluated the in… |
| ECT | Mazères et al · J Control Release | 2009 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | For an effective tissue controlled electropermeabilization as requested for electrochemotherapy and electrogenotherapy, it is very important to have informations about the electric field dis… |
| ECT | Todorovic et al · Radiology and Oncology | 2009 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Background. Electrochemotherapy is a local treatment combining application of electric pulses and chemotherapy. Two chemotherapeutic drugs, bleomycin and cisplatin, have proved to be effecti… |
| Other EP | Hojman et al · Biol Proced Online | 2009 | Animal Study | Animal (In Vivo) | – | DNA electrotransfer to muscle tissue yields long-term, high levels of gene expression; showing great promise for future gene therapy. We want to characterize the novel far-red fluorescent pr… |
| Other EP | Radkevich-Brown et al · Cancer Immunol Immunother | 2009 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation | In situ expression of a foreign antigen and an immune-modulating cytokine by intratumoral DNA electroporation was tested as a cancer therapy regimen. Transgene expression in the tumors was s… |
| Gene ET | Tevz et al · J Gene Med | 2009 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Interleukin-12 Mediated Immune Stimulation | Background: The present study aimed to evaluate the antitumor effectiveness of systemic interleukin (IL)-12 gene therapy in murine sarcoma models, and to evaluate its interaction with the ir… |
| Other EP | Cemazar et al · Gene Ther | 2009 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | Electrotransfer (electroporation) is recognized as one of the most promising alternatives to viral vectors for transfection of different tissues in vivo for therapeutic purposes. We evaluate… |
| IRE | Daniels et al · J Biomech Eng | 2009 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive surgical technique that is part of the emerging field of molecular surgery, which holds the potential to treat dis… |
| IRE | Granot et al · Phys Med Biol | 2009 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Electroporation, the increased permeability of cell membranes due to a large transmembrane voltage, is an important clinical tool. Both reversible and irreversible in vivo electroporation ar… |
| ECT | Sersa et al · Br J Cancer | 2008 | Animal Study | Animal (In Vivo) | Antivascular Effect and Vessel Disruption, Increased Intracellular Bleomycin Accumulation | Electrochemotherapy has a direct cytotoxic effect on tumour cells, and presumably, a vascular disrupting effect. In this study, on the basis of the prediction of the mathematical model, hist… |
| ECT | Ivorra et al · Phys Med Biol | 2008 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Electroporation is used in tissue for gene therapy, drug therapy and minimally invasive tissue ablation. The electrical field that develops during the application of the high voltage pulses … |
| Other EP | Pucihar et al · Biophys J | 2008 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | The transport of propidium iodide into electropermeabilized Chinese hamster ovary cells was monitored with a photomultiplier tube during and after the electric pulse. The influence of pulse … |
| ECT | Čorović et al · Technol Cancer Res Treat | 2008 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemot… |
| Other EP | Anon · Molecular Therapy | 2008 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Bone marrow stromal cells (BMSC) are the adherent cells of the bone marrow and contain a subpopulation of mesenchymal stem cells. BMSC can be used in the treatment of multitude of diseases a… |
| Other EP | Benencia et al · J Transl Med | 2008 | Animal Study | Animal (In Vivo) | Apoptosis Induction | Because of the lack of full characterization of tumor associated antigens for solid tumors, whole antigen use is a convenient approach to tumor vaccination. Tumor RNA and apoptotic tumor cel… |
| Other EP | Mesojednik et al · Radiology and Oncology | 2008 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Evaluation of shRNA-mediated gene silencing by electroporation in LPB fibrosarcoma cellsBackground. Silencing oncogenes or other genes that contribute to tumor malignancy and progression off… |
| Gene ET | Tevz et al · Technol Cancer Res Treat | 2008 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Necrosis and Necroptosis | Skeletal muscle is an attractive target tissue for delivery of therapeutic genes, since it is well vascularized, easily accessible, and has a high capacity for protein synthesis. For efficie… |
| Other EP | Anon · Molecular Therapy | 2007 | Animal Study | Animal (In Vivo) | – | This publication has no abstract. |
| Other EP | Anon · Molecular Therapy | 2007 | Animal Study | Animal (In Vivo) | – | This publication has no abstract. |
| Other EP | Anon · Molecular Therapy | 2007 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Delivery Feng Lin,' Kate Broderick,' Jonas Soderholm,' Kristen Smits,' Torunn E. Tjelle,' Dietmar Rabussay,' lacob Mathiesen,' Rune Kjeken .' Research and Development, lnovio Biomedical Corp… |
| Gene ET | Cukjati et al · Bioelectrochemistry | 2007 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Electric Field Distribution and Modelling | In vivo cell electroporation is the basis of DNA electrotransfer, an efficient method for non-viral gene therapy using naked DNA. The electric pulses have two roles, to permeabilize the targ… |
| Gene ET | Hojman et al · BMC Mol Biol | 2007 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Background: Gene transfer by electroporation (DNA electrotransfer) to muscle results in high level long term transgenic expression, showing great promise for treatment of e.g. protein defici… |
| Other EP | Hooper et al · Vaccine | 2007 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Previously, we demonstrated that an experimental smallpox DNA vaccine comprised of four vaccinia virus genes (4pox) administered by gene gun elicited protective immunity in mice challenged w… |
| Other EP | Granot et al · Physiol Meas | 2007 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Potentiation of Cytotoxic Drug Permeability | Tissue electroporation is a medical technique in which electrical pulses of microsecond to millisecond length are applied to a tissue in order to permeabilize the membrane of targeted cells,… |
| IRE | Al-Sakere et al · Technol Cancer Res Treat | 2007 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Immune cell recruitment during the treatment of sarcoma tumors in mice with irreversible electroporation was studied by immunohistochemistry. Irreversible electroporation is a non-thermal ti… |
| IRE | Lee et al · Technol Cancer Res Treat | 2007 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Apoptosis Induction | Preliminary results of percutaneous irreversible electroporation (PIE) on swine liver as a novel non-thermal ablation are presented. The goal of this study was to evaluate the feasibility of… |
| IRE | Maor et al · Technol Cancer Res Treat | 2007 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | We present a pilot study on the long term effects of irreversible electroporation (IRE) on a large blood vessel. The study was motivated by the anticipated use of IRE for treatment of cancer… |
| IRE | Rubinsky et al · Technol Cancer Res Treat | 2007 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a new tissue ablation technique in which micro to millisecond electrical pulses are delivered to undesirable tissue to produce cell necrosis through irr… |
| ECT | Cemazar et al · Anticancer Res | 2006 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation | Background: The in vitro cytotoxic activity of two new platinum(II) complexes (3P-SK and PtAMP) in comparison with cisplatin (CDDP), oxaliplatin (OXA) and carboplatin (CARBO) was determined … |
| ECT | Cemazar et al · Biochem Biophys Res Commun | 2006 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation | Imaging methods can give both temporal and spatial dimensions to characterize the processes in progression of and/or treatment of specific disease Subcutaneous tumors can be cured after elec… |
| ECT | Labanauskiene et al · Medicina (Kaunas) | 2006 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | By applying electric pulses to tumor the membrane of tumor cells undergoes destabilization that enables the drug molecules to enter into the cells more freely and selectivity of anticancer d… |
| Other EP | Mossop et al · Ann Biomed Eng | 2006 | Animal Study | Animal (In Vivo) | Electrode Geometry and Placement, Electric Field Distribution and Modelling | The intratumoral field, which determines the efficiency of electric field-mediated drug and gene delivery, can differ significantly from the applied field. Therefore, we investigated the dis… |
| Other EP | Rols · Biochim Biophys Acta | 2006 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | Electropermeabilization designates the use of short high-voltage pulses to overcome the barrier of the cell membrane. A position-dependent reversible local membrane permeabilization is induc… |
| Other EP | Shil et al · J Environ Pathol Toxicol Oncol | 2006 | Animal Study | Animal (In Vivo) | – | Treatment of cancer patients is subject to limitations in radiotherapy and chemotherapy. This necessitates development of new protocols, and the present work reports on the effects of a comb… |
| ECT | Soden et al · Cancer Lett | 2006 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Electrode Geometry and Placement | Electroporation is the application of very brief electric pulses to cells or tissues to render the cell membranes transiently and reversibly permeable, facilitating cellular uptake of otherw… |
| Other EP | Andre et al · Molecular Therapy | 2006 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Optimisation of Pulse Parameters | The major limitation of gene therapy is the vector used for gene transfer. Viruses were used first and are still the most common approach. Due to adverse events in clinical trials, there was… |
| Gene ET | Bloquel et al · BMC Biotechnol | 2006 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Background: Optical imaging is an attractive non-invasive way to evaluate the expression of a transferred DNA, mainly thanks to its lower cost and ease of realization. In this study optical … |
| Gene ET | Herrero-Fresneda et al · Kidney Int | 2006 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Inflammatory processes and tissue scarring are characteristic features of chronic allograft nephropathy. Hepatocyte growth factor (HGF) has beneficial effects on renal fibrosis and it also a… |
| Other EP | Tjelle et al · Vaccine | 2006 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | Intramuscular injection of plasmid DNA followed by electrical stimulation (electroporation) is an efficient method for achieving therapeutic levels of encoded proteins or eliciting efficient… |
| IRE | Kandušer et al · Eur Biophys J | 2005 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | In this paper, we report the results of a systematic attempt to relate the intrinsic plasma membrane fluidity of three different cell lines to their electroporation behaviour, which consists… |
| ECT | Larkin et al · Ir J Med Sci | 2005 | Animal Study | Animal (In Vivo) | – | SYLVESTER o'HALLORAN SURGICAL SCIENTIFIC MEETING • 4 - 5 MARCH 2005 • JEAN MONNET THEATRE, UNIVERSITY OF LIMERICK art" >,9R Modulation of coregulatory protein expression in human breast canc… |
| ECT | Miklavčič et al · Bioelectrochemistry | 2005 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Muscle Contraction and Anaesthesia Requirement | Muscle contractions present the main source of unpleasant sensations for patients undergoing electrochemotherapy. The contractions are a consequence of high voltage pulse delivery. Relativel… |
| ECT | Šatkauskas et al · Bioelectrochemistry | 2005 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Necrosis and Necroptosis | The aim of this study was to evaluate the effectiveness of electrochemotherapy (ECT) as a function of various combinations of pulse strength and duration. C57Bl mice bearing LLC tumors were … |
| Gene ET | Li et al · Mol Ther | 2005 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Gene Electrotransfer (Plasmid DNA) | Injection of DNA via electric pulses into targeted tissues is referred to as electrotransfer. Intratumoral electrotransfer of the IL12 gene is more effective than intramuscular electrotransf… |
| Other EP | Šatkauskas et al · Hum Gene Ther | 2005 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | Efficient DNA electrotransfer can be achieved with combinations of short high-voltage (HV) and long low voltage (LV) pulses that cover two effects of the pulses, namely, target cell electrop… |
| ECT | Mali et al · J Med Eng Technol | 2005 | Animal Study | Animal (In Vivo) | – | The combined treatment of tumours in which delivery of a chemotherapeutic agent is followed by high voltage electroporation pulses has been termed electrochemotherapy. The electrochemotherap… |
| ECT | Soden et al · Conf Proc IEEE Eng Med Biol Soc | 2005 | Animal Study | Animal (In Vivo) | Electrode Geometry and Placement, Increased Intracellular Bleomycin Accumulation | Therapeutic "electroporation" involves application of electric fields to target cells/tissues, thereby rendering their cell membranes transiently porous, thus making feasible the cellular up… |
| Other EP | Maxim et al · Radiat Res | 2004 | Animal Study | Animal (In Vivo) | – | Tumor hypoxia is associated with resistance to radiotherapy and anticancer chemotherapy. However, it can be exploited to therapeutic advantage by concomitantly using hypoxic cytotoxins, such… |
| Other EP | Pliquett et al · Bioelectrochemistry | 2004 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Electrode Geometry and Placement | The artificial electrotransfer of bioactive agents such as drugs, peptides or therapeutical nucleic acids and oligonucleotides by membrane electroporation (MEP) into single cells and tissue … |
| Other EP | Cemazar · BMC Cancer | 2004 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Gene Electrotransfer (Plasmid DNA) | Background: Electroporation is currently receiving much attention as a way to increase drug and DNA delivery. Recent studies demonstrated the feasibility of electrogene therapy using a range… |
| Other EP | Li et al · Mol Ther | 2004 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation, Gene Electrotransfer (Plasmid DNA) | Interleukin-12 (IL-12) is one of the most effective cytokines for treating malignancy. Intratumoral delivery of the murine Il-12 gene, using electroporation, has been found effective in indu… |
| Other EP | Davalos et al · IEEE Trans Biomed Eng | 2004 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Electroporation is a method to introduce molecules, such as gene constructs or small drugs, into cells by temporarily permeating the cell membrane with electric pulses. In molecular medicine… |
| ECT | Kitamura · Cancer Chemother Pharmacol | 2003 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Apoptosis Induction | Purpose: To determine whether or not low-voltage electrochemotherapy has cell killing effects. Materials: Dorsally transplanted NR-S1 carcinomas in mice were stimulated with electric pulses … |
| Other EP | Anon · Molecular Therapy | 2003 | Animal Study | Animal (In Vivo) | – | This publication has no abstract. |
| Other EP | Anon · Molecular Therapy | 2003 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation | This publication has no abstract. |
| Other EP | Anon · Molecular Therapy | 2003 | Animal Study | Animal (In Vivo) | – | This publication has no abstract. |
| ECT | Ivanov et al · J Gene Med | 2003 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | Background: MBD2 is a methylated DNA-binding protein that has been previously suggested to have transcriptional silencing as well as DNA demethylase activities. We have previously shown that… |
| Other EP | Davalos et al · Bioelectrochemistry | 2003 | Animal Study | Animal (In Vivo) | Electrode Geometry and Placement, Thermal Effect and Joule Heating | Tissue electroporation is a technique that facilitates the introduction of molecules into cells by applying a series of short electric pulses to specific areas of the body. These pulses temp… |
| Other EP | Pliquett · Med Biol Eng Comput | 2003 | Animal Study | Animal (In Vivo) | Thermal Effect and Joule Heating, Electric Field Distribution and Modelling | The application of high-voltage pulses to biological tissue causes not only electroporation, a non-thermal phenomenon of pore creation within a lipid membrane due to an elevated electric fie… |
| ECT | Dujardin · J Control Release | 2002 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Tissue Conductivity and Impedance Change | The application of short-duration high-voltage pulses to the skin has been shown to enhance transdermal drug delivery by several orders of magnitude and to transiently permeabilize cells in … |
| ECT | Heller et al · Technol Cancer Res Treat | 2002 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Necrosis and Necroptosis | The efficient delivery of drugs to tumors is an important tool for the treatment of a variety of cancers. Electric pulses have been shown to facilitate the uptake of molecules through the ce… |
| ECT | Mitsui et al · Drug Deliv | 2002 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | We investigated the cytotoxicity on the combination of bleomycin (BLM) with electric pulses against transplanted bladder tumors in nude mice. Loading with high-voltage electric pulse after i… |
| Other EP | Golzio et al · Proc Natl Acad Sci U S A | 2002 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | Electropermeabilization is one of the nonviral methods successfully used to transfer genes into living cells in vitro and in vivo. Although this approach shows promise in the field of gene t… |
| Other EP | Li · J Natl Cancer Inst | 2002 | Animal Study | Animal (In Vivo) | Interleukin-12 Mediated Immune Stimulation | Background Interleukin 12 (IL-12) is a proinflammatory cytokine with antitumor activity. Plasmid-based intratumoral gene therapy for treating malignancy with IL-12 or other genes is safe, in… |
| Other EP | Satkauskas et al · Mol Ther | 2002 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | Efficient cell electrotransfection can be achieved using combinations of high-voltage (HV; 800 V/cm, 100 micros) and low-voltage (LV; 80 V/cm, 100 ms) pulses. We have developed equipment all… |
| ECT | Lebar et al · Anticancer Res | 2002 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters | The aim of our study was to optimise electric pulse parameters for electrochemotherapy by sampling the space of pulse parameter variables using systematic in vitro experiments. For this purp… |
| ECT | Cemazar et al · Eur J Cancer | 2001 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation | The aim of the study was to determine whether electrochemotherapy with cisplatin could be implemented in treatment of cisplatin-resistant solid tumours. For this purpose, we used cisplatin-s… |
| ECT | Kranjc et al · European Journal of Cancer | 2001 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Antivascular Effect and Vessel Disruption | There is abundant evidence that t u m o r - ~ Ixnteelylicfactms uPA type l~lasminogen_activator)and its inhibitorPAI-1 play a key role in tum~ invmion and metastasis. Elevated levels of thes… |
| Other EP | Lucas et al · DNA Cell Biol | 2001 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA) | In vivo electroporation is currently accomplished by one of two types of common waveforms: exponential decay or square-wave pulses. The purpose of this report is to present a new electropora… |
| Other EP | Cemazar et al · Br J Radiol | 2000 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability | For effective boron neutron capture therapy (BNCT) it is important that a sufficient concentration of boron (10B) is present in the tumour during irradiation. This requirement represents a s… |
| Other EP | Kotnik et al · Biotechniques | 2000 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | For the evaluation of cell membrane electropermeabilization, cells are usually exposed to electric pulses in the presence of propidium iodide, a fluorescent dye activated by binding to cellu… |
| ECT | Serša et al · Int J Radiat Oncol Biol Phys | 2000 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Potentiation of Cytotoxic Drug Permeability | Purpose: To evaluate whether a local drug delivery method, i.e., electroporation of tumors, increases the radiosensitizing effect of cisplatin. Methods and materials: Subcutaneous Ehrlich-Le… |
| Other EP | Goto et al · Proc Natl Acad Sci U S A | 2000 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Optimisation of Pulse Parameters | We report successful electro-gene therapy (EGT) by using plasmid DNA for tumor-bearing mice. Subcutaneously inoculated CT26 tumor was subjected to EGT, which consists of intratumoral injecti… |
| ECT | Miklavčič et al · Biochim Biophys Acta | 2000 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | Permeabilising electric pulses can be advantageously used for DNA electrotransfer in vivo for gene therapy, as well as for drug delivery. In both cases, it is essential to know the electric … |
| ECT | Cemazar et al · Br J Cancer | 1999 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Reversible Membrane Permeabilisation | Electrochemotherapy is an anti-tumour treatment that utilizes locally delivered electric pulses to increase cytotoxicity of chemotherapeutic drugs. The aim of our study was to determine whet… |
| ECT | Sersa et al · Anticancer Res | 1999 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Vascular Lock Effect | Background: Electrochemotherapy combines administration of the chemotherapeutic drug, followed by application of electric pulses in order to increase drug delivery into the cells. The aim of… |
| Other EP | Vanbever et al · Adv Drug Deliv Rev | 1999 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Electrode Geometry and Placement | This article reviews the studies on skin electroporation carried out in vivo in animals and emphasizes its potential therapeutic applications for transdermal and topical drug delivery. In ag… |
| Other EP | Jaroszeski et al · Adv Drug Deliv Rev | 1999 | Animal Study | Animal (In Vivo) | – | The physical phenomenon of electroporation has been successfully exploited in vitro for the delivery of genes, drugs, and other molecules with increasing frequency over the past two decades.… |
| Other EP | Mir et al · Proc Natl Acad Sci U S A | 1999 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Gene delivery to skeletal muscle is a promising strategy for the treatment of muscle disorders and for the systemic secretion of therapeutic proteins. However, present DNA delivery technolog… |
| ECT | Gehl et al · Anticancer Drugs | 1998 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Electropermeabilization (EPN), also termed electroporation, is a physical method to overcome the barrier of the cell membrane by applying short and intense electric pulses. It is the basis f… |
| Other EP | Neumann et al · Biophys J | 1998 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Electric Field Distribution and Modelling | The color change of electroporated intact immunoglobulin G receptor (Fc gammaR-) mouse B cells (line IIA1.6) after direct electroporative transfer of the dye SERVA blue G (Mr 854) into the c… |
| Other EP | Serŝa et al · Electro- and Magnetobiology | 1998 | Animal Study | Animal (In Vivo) | – | The effect of application of short, intense electric pulses on tumor blood volume was investigated using albumin-(Gd-DTPA)30 contrast-enhanced magnetic resonance imaging (MRI). One of paired… |
| ECT | Čemazar et al · Anticancer Drugs | 1998 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Optimisation of Pulse Parameters | Electrochemotherapy using intratumoral cisplatin administration was tested on EAT tumors in mice. Mice were treated with eight electric pulses (100 micros, 1 Hz, 1040 V) and/or cisplatin (1,… |
| ECT | Čemažar et al · Jpn J Cancer Res | 1998 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | Electrochemotherapy (ECT) involves the use of locally applied electric pulses to increase delivery of chemotherapeutic drugs into cells in tissues. ECT with bleomycin (BLM) is a very effecti… |
| ECT | Šemrov et al · Comput Biol Med | 1998 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | Electrochemotherapy is a novel approach in chemotherapeutic drug delivery into tumours. Short intense direct current electric pulses are applied to tumour tissue causing electropermeabilisat… |
| ECT | Miklavčič et al · Biophys J | 1998 | Animal Study | Animal (In Vivo) | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | Cells exposed to short and intense electric pulses become permeable to a number of various ionic molecules. This phenomenon was termed electroporation or electropermeabilization and is widel… |
| ECT | Serša et al · Cancer Lett | 1997 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tum… |
| ECT | Serša et al · Magn Reson Med | 1997 | Animal Study | Animal (In Vivo) | Tissue Conductivity and Impedance Change, Electrode Geometry and Placement | The use of electric current density imaging (CDI) to map spatial distribution of electric currents through tumors is presented. Specifically, a method previously tested on phantoms was imple… |
| Other EP | Zhang et al · Bioelectrochemistry and Bioenergetics | 1997 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Gene Electrotransfer (Plasmid DNA) | Successful development of a noninvasive topical-based delivery system ,ff therapeutic ageing, with a handy a~licator, will allow for targeted and efficient in vivo gene transfer without the … |
| ECT | Gilbert et al · Biochim Biophys Acta | 1997 | Animal Study | Animal (In Vivo) | Electrode Geometry and Placement | Direct current pulses for electrochemotherapy treatment are typically administered using two parallel plate electrodes that are placed on either side of the tumor. This simple design has pro… |
| ECT | Jaroszeski et al · Melanoma Res | 1996 | Animal Study | Animal (In Vivo) | – | Electrochemotherapy has been demonstrated to be an effective treatment for cutaneous cancers. The treatment includes administering a chemotherapeutic agent followed by electric pulses which … |
| ECT | Serša et al · Bioelectrochemistry and Bioenergetics | 1996 | Animal Study | Animal (In Vivo) | Transmembrane Potential Change, Potentiation of Cytotoxic Drug Permeability | Electrochemotherapy is a new and promising approach in treatment of tumors employing locally applied high voltage d.c. electric pulses in combination with chemotherapeutic drugs. Increased p… |
| ECT | Sersa et al · Anticancer Drugs | 1996 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | Electrochemotherapy is an antitumor treatment that utilizes locally delivered electric pulses to increase the effectiveness of chemotherapeutic drugs in cells and tissues. Electric pulses pe… |
| Other EP | Gabriel ve Teissie · Eur J Biochem | 1995 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Electric Field Distribution and Modelling | When electropulsed by short strong electric field pulses, cells can be permeabilized transiently (electropermeabilization). The transient electroinduced membrane restructuration which suppor… |
| Other EP | Rols et al · Biochem Biophys Res Commun | 1995 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | Electropermeabilization is a technique which allows free access of molecules to cytosol. In the present study, we report on results dealing with the penetration of macromolecules. Under elec… |
| ECT | Sersa et al · Cancer Res | 1995 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Optimisation of Pulse Parameters | One of the ways to increase drug delivery into cells and tissues is by a local application of short, intense electric pulses, i.e., electropermeabilization. This approach is used in electroc… |
| Other EP | EL OUAGARI et al · Eur J Biochem | 1994 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | Electropulsation allowed us to incorporate glycophorin A, an integral membrane protein, into mammalian nucleated cell membranes (Chinese hamster ovary cells). The induction of stable protein… |
| Other EP | Jean Belehradek et al · Biochim Biophys Acta | 1994 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Using cells in suspension, electropermeabilization is a technique extensively used to transfect living cells or to introduce a variety of compounds inside the cells. Here we demonstrate the … |
| ECT | Serša et al · Bioelectrochemistry and Bioenergetics | 1994 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | Electrochemotherapy is a new approach in the treatment of tumors that takes advantage of the permeabilization of the cell membrane by electric pulses to facilitate the delivery of chemothera… |
| Other EP | TEISSIE et al · Ann N Y Acad Sci | 1994 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | Electropermeabilization is a convenient technique to gain access to the cytoplasm. It appears not to be drastic for the cells, has the advantages of high reproducibility and reversibility, a… |
| ECT | M Belehradek, C Domenge, B Luboinski, S Orlowski, J Belehradek, L Mir · Cancer | 1993 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | Electrochemotherapy is a new antitumor treatment consisting of electrical pulses administered to the tumor several minutes after intravenous injection of bleomycin. In mice, important antitu… |
| Other EP | Rols et al · Biochim Biophys Acta | 1992 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | Chinese hamster ovary (CHO) cells and human erythrocytes were pulsed by using square-wave electric-field pulses. This treatment induced their permeabilization. This phenomenon appears to be … |
| ECT | Mir et al · Eur J Cancer | 1991 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | In cell culture the cytotoxicity of some anticancer drugs, especially bleomycin, can be greatly enhanced by exposing cells to non-cytotoxic electric pulses. Nude or conventional mice bearing… |
| Other EP | Rols et al · Biochemistry | 1990 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | Cells can be made temporarily permeable if pulsed by high-intensity short-duration electric fields. The molecular mechanisms underlying this electropermeabilization are still unknown. The ki… |
| Other EP | Mir et al · Exp Cell Res | 1988 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation | The possibility of introducing definite amounts of nonpermeant molecules into electropermeabilized living cells has been approached by quantifying the amounts of Lucifer Yellow (LY; a 457-Da… |
| Other EP | Orlowski et al · Biochem Pharmacol | 1988 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | The electropermeabilization (EPN) of living cells allows the uptake of non-permeant molecules and can reveal their potential activity on cells without the constraints of the plasma membrane … |
| Other EP | Szwedowicz et al · Biomed Pharmacother | 2026 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | Background: Electroporation (EP) is widely applied in electrochemotherapy to enhance drug delivery by transient membrane permeabilization. However, its impact on intercellular communication … |
| ECT | Alkis et al · Bioorg Chem | 2026 | In Vitro Study | Cell Culture | Potentiation of Cytotoxic Drug Permeability | A novel niraparib-derived Schiff base (Sb) ligand and its Pd(II) and Fe(II) complexes were synthesized and comprehensively characterized using elemental and thermal analyses, 1 H, 13 C NMR, … |
| Other EP | Giovannini et al · Bioelectrochemistry | 2026 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | Electroporation is a promising technique for enhancing the delivery of therapeutic agents by transiently increasing cell membrane permeability through high-amplitude (from hundreds of V/cm t… |
| Calcium EP | Gürsoy et al · Cukurova Med J | 2026 | In Vitro Study | Cell Culture | Calcium Electroporation and ATP Depletion, Apoptosis Induction | Purpose: This study aimed to evaluate the effects of calcium electroporation on cell viability, energy metabolism, and cell survival signaling pathways in the colon cancer cell line DLD-1.Ma… |
| ECT | Neville et al · Radiol Oncol | 2026 | In Vitro Study | Cell Culture | Increased Intracellular Cisplatin Accumulation, Reversible Membrane Permeabilisation | Background: Reversible electroporation involves the use of pulsed electric fields to temporarily disrupt and permeabilise cell membranes. Electroporation combined with chemotherapy - electro… |
| Other EP | Xia et al · Bioelectrochemistry | 2026 | In Vitro Study | Cell Culture | Thermal Effect and Joule Heating, Potentiation of Cytotoxic Drug Permeability | Microneedle electroporation holds promise for enhancing dermal gene and drug delivery, yet the biophysical consequences of millisecond exponential-decay pulses remain incompletely characteri… |
| Other EP | Zhou et al · Bio-des. Manuf. | 2026 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | Reversible electroporation (RE) involves applying pulsed electric fields to briefly disrupt cell membrane channels, allowing molecular transfer while preserving cell viability. Advances in R… |
| Other EP | Polajžer et al · Bioelectricity | 2026 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Tissue Conductivity and Impedance Change | Introduction: High-intensity pulsed electromagnetic fields (HI-PEMF) can be used to trigger contactless permeabilization of the plasma membrane similar to electroporation (EP). The permeabil… |
| IRE | Batista Napotnik et al · Sci Rep | 2026 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Disruption of Calcium Homeostasis | In recent years, irreversible electroporation has been increasingly used to treat cardiac arrhythmias, an approach termed pulsed field ablation. The mechanisms of how electroporation affects… |
| IRE | Han et al · Biomater Res | 2026 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) remodels the tumor microenvironment to enhance biomaterial and nanoparticle (NP) delivery and immune activation, making combinational IRE-nanomedicine a pr… |
| IRE | Liu et al · iRADIOLOGY | 2026 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is an emerging tumor ablation technique that induces permanent damage to cellular membranes through the application of high‐intensity short‐duration electr… |
| IRE | Vallin · Bioeng Transl Med | 2026 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a focal ablative cancer therapy that destroys cells through membrane destabilization via pulsed electric fields. It also has the capacity to induce a sy… |
| ECT | Plešnik et al · J Pharm Biomed Anal | 2025 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Optimisation of Pulse Parameters | Bleomycin, a cytotoxic antibiotic, poses substantial challenges for mass spectrometry-based analysis due to its extreme polarity, chelating properties, heterogeneity of fractions, and propen… |
| IRE | Murthy · Cancers (Basel) | 2025 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Background: The Canady Helios Cold Plasma (CHCP) system is a non-thermal, non-contact cold atmospheric plasma technology that generates transient electric fields and reactive species capable… |
| IRE | Wang et al · Bioelectrochemistry | 2025 | In Vitro Study | Cell Culture | Apoptosis Induction, Mitochondrial Dysfunction and Oxidative Stress | Sirtuin proteins have key roles in cancer progression and metastases. However, their role in bioelectrical modulation via high-frequency irreversible electroporation (H-FIRE) remains poorly … |
| IRE | Williamson et al · J Vis Exp | 2025 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Electroporation is a promising technology utilizing electrical pulses for macromolecule delivery and soft-tissue ablation, with applications that include next-generation prophylactics and th… |
| Other EP | Batista Napotnik et al · J Vis Exp | 2024 | In Vitro Study | Cell Culture | Transmembrane Potential Change | Excitable cells such as neuronal and muscle cells can be primary targets in rapidly emerging electroporation-based treatments. However, they can be affected by electric pulses even in therap… |
| ECT | Calvel et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2024 | In Vitro Study | Cell Culture | Potentiation of Cytotoxic Drug Permeability | Among all the cancer treatments developed, electrochemotherapy has shown great promise in recent decades. This approach combines the local delivery of electric pulses with the administration… |
| Other EP | Choromańska et al · Biochim Biophys Acta Gen Subj | 2024 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation | Although the pulse electric field (PEF) has been used in electrochemotherapy (ECT) for many years, the kinetics and profile of extracellular particles (EPs) released as a result of reversibl… |
| Calcium EP | Lisec · Cell Commun Signal | 2024 | In Vitro Study | Cell Culture | Calcium Electroporation and ATP Depletion, Disruption of Calcium Homeostasis | Background: Disruption of Ca 2+ homeostasis after calcium electroporation (CaEP) in tumors has been shown to elicit an enhanced antitumor effect with varying impacts on healthy tissue, such … |
| ECT | Lopes et al · Med Eng Phys | 2024 | In Vitro Study | Cell Culture | Electrode Geometry and Placement, Electric Field Distribution and Modelling | Electrochemotherapy is a cancer treatment in which local pulsed electric fields are delivered through electrodes. The effectiveness of the treatment depends on exposing the tumor to a thresh… |
| Other EP | Mondal et al · J Membr Biol | 2024 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversi… |
| Calcium EP | Radzevičiūtė-Valčiukė et al · Bioelectrochemistry | 2024 | In Vitro Study | Cell Culture | Calcium Electroporation and ATP Depletion, Reversible Membrane Permeabilisation | Calcium electroporation is a modality of electrochemotherapy (ECT), which is based on intracellular electric field-mediated delivery of cytotoxic doses of calcium into the cells resulting in… |
| IRE | Strucic et al · Radiol Oncol | 2024 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Background: Administering gadolinium-based contrast agent before electroporation allows the contrast agent to enter the cells and enables MRI assessment of reversibly electroporated regions.… |
| ECT | Zamuner et al · Bioelectrochemistry | 2024 | In Vitro Study | Cell Culture | Preservation of Extracellular Matrix and Tissue Scaffold, Transmembrane Potential Change | Electrochemotherapy (ECT) with bleomycin is an effective antitumor treatment. Still, researchers are investigating new drugs and electroporation conditions to improve its efficacy. To this a… |
| Other EP | Pavlin et al · Biomed Eng Online | 2024 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Background: Electrotransfection is based on application of high-voltage pulses that transiently increase membrane permeability, which enables delivery of DNA and RNA in vitro and in vivo. It… |
| Other EP | Torabi et al · Biomed Eng Online | 2024 | In Vitro Study | Cell Culture | – | Background: Extracellular vesicles (EVs) have emerged as an exciting tool for targeted delivery of therapeutics for a wide range of diseases. As nano-scale membrane-bound particles derived f… |
| Gene ET | Ušaj et al · – | 2024 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA), Optimisation of Pulse Parameters | In the search for safe induction of cellular and humoral cancer immunity dendritic cell-based therapies hold great potential. This approach is based on manipulation of dendritic cells to act… |
| Other EP | Collin · ESAIM: COCV | 2024 | In Vitro Study | Cell Culture | – | The estimation of partial differential systems (PDE) – in particular, the identification of their parameters – is fundamental in many applications to combine modeling and available measureme… |
| Other EP | Müller et al · Sci Rep | 2024 | In Vitro Study | Animal (In Vivo) | Thermal Effect and Joule Heating, Irreversible Pore Formation and Cell Death | Medical devices and technologies must undergo extensive testing and validation before being certified for public healthcare use, especially in oncology where a high research focus is on new … |
| IRE | Lv et al · IEEE Trans Biomed Eng | 2024 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Unlabelled: The H-FIRE (high-frequency irreversible electroporation) protocol employs high-frequency bipolar pulses (HFBPs) with a width of ∼1 µs for tumor ablation with slight muscle contra… |
| ECT | Kranjc Brezar et al · Bioelectrochemistry | 2023 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Electrochemotherapy (ECT) is a local ablative therapy for the treatment of different skin and subcutaneous tumors and certain tumors in internal organs. Skeletal muscle represents a major tu… |
| Gene ET | Kranjc et al · Int J Mol Sci | 2023 | In Vitro Study | Cell Culture | Immunogenic Cell Death (ICD), Gene Electrotransfer (Plasmid DNA) | High-Intensity Pulsed Electromagnetic Fields (HI-PEMF) treatment is an emerging noninvasive and contactless alternative to conventional electroporation, since the electric field inside the t… |
| ECT | Lin et al · Talanta | 2023 | In Vitro Study | Cell Culture | Preservation of Extracellular Matrix and Tissue Scaffold | Cell density is important for tumour metastasis, treatment and prognosis. Characterizing changes in cell density for electrochemotherapy (ECT) can reveal sub-populations in pathological stat… |
| Calcium EP | Lisec et al · – | 2023 | In Vitro Study | Cell Culture | Calcium Electroporation and ATP Depletion, Optimisation of Pulse Parameters | Background The vascular endothelium consists of endothelial cells (ECs) with important biological functions, and their impairment is associated with various pathologies. ECs vary based on ti… |
| ECT | Kis et al · BVSZ | 2023 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation | Electrochemotherapy is a widely used locoregional method for the treatment of superficial tumors with different histologies. During treatment, a chemotherapeutic drug, usually bleomycin, is … |
| Gene ET | Komel et al · Bioelectrochemistry | 2023 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA) | Fluorescent reporter genes are widely used to study the transfection of various types of primary cells and cell lines. The aim of our research was to investigate the expression dynamics of G… |
| IRE | Polajžer et al · Vaccines (Basel) | 2023 | In Vitro Study | Cell Culture | Immunogenic Cell Death (ICD), Optimisation of Pulse Parameters | Traditionally, electroporation-based therapies such as electrochemotherapy (ECT), gene electrotransfer (GET) and irreversible electroporation (IRE) are performed with different but typical p… |
| Gene ET | de Caro et al · Pharmaceutics | 2023 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Electroporation, a method relying on a pulsed electric field to induce transient cell membrane permeabilization, can be used as a non-viral method to transfer genes in vitro and in vivo. Suc… |
| ECT | Vélez Salazar et al · Biophys J | 2023 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Vascular Lock Effect | The convective delivery of chemotherapeutic drugs in cancerous tissues is directly proportional to the blood perfusion rate, which in turns can be transiently reduced by the application of h… |
| IRE | Peng et al · Ann Biomed Eng | 2023 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters | The mechanisms of cell death due to electroporation are still not well understood. Recent studies suggest that cell death due to electroporation is not an immediate all-or-nothing response b… |
| ECT | Wolff et al · Biomedicines | 2022 | In Vitro Study | Cell Culture | Mitochondrial Dysfunction and Oxidative Stress, Immunogenic Cell Death (ICD) | In modern oncology, therapies are based on combining monotherapies to overcome treatment resistance and increase therapy precision. The application of microsecond-pulsed electric fields (PEF… |
| ECT | Andrade et al · Sci Rep | 2022 | In Vitro Study | Cell Culture | Electrode Geometry and Placement | Electrochemotherapy is a selective electrical-based cancer treatment. A thriving treatment depends on the local electric field generated by pairs of electrodes. Electrode damage as deflectio… |
| ECT | Bendix et al · Bioelectrochemistry | 2022 | In Vitro Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Electric Field Distribution and Modelling | Electrochemotherapy (ECT) is becoming an established therapy for melanoma and is under investigation for application in additional cancer types. One potential cancer type that may benefit fr… |
| ECT | Gursoy et al · Med Oncol | 2022 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Low-dose chemotherapy in advanced stages of cancer does not give a positive response in treatment. The use of high-dose antineoplastic drugs creates significant side effects. The limiting si… |
| IRE | Lv et al · Bioelectrochemistry | 2022 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Electroporation achieved by the application of pulsed electric field is successfully used for clinical tumor ablation. Electrochemotherapy (ECT) and irreversible electroporation (IRE), which… |
| Other EP | Novickij et al · Biochim Biophys Acta Biomembr | 2022 | In Vitro Study | Cell Culture | Mitochondrial Dysfunction and Oxidative Stress, Reversible Membrane Permeabilisation | Pulsed electric fields (PEFs) are commonly used to facilitate the delivery of various molecules, including pharmaceuticals, into living cells. However, the applied protocols still require op… |
| Other EP | Watanabe et al · Sensors (Basel) | 2022 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Tissue Conductivity and Impedance Change | Membrane permeabilization stimulated by high-voltage electric pulses has been used to deliver cell-impermeable exogenous molecules. The electric field effect on the cells depends on various … |
| Other EP | Brooks et al · Biosens Bioelectron | 2022 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change, Transmembrane Potential Change | In vitro intracellular delivery is a fundamental challenge with no widely adopted methods capable of both delivering to millions of cells and controlling that delivery to a high degree of ac… |
| IRE | Collin et al · AIMSBOA | 2022 | In Vitro Study | Cell Culture | – | This publication has no abstract. |
| Other EP | Poulkouras et al · Bioelectrochemistry | 2022 | In Vitro Study | Cell Culture | Mitochondrial Dysfunction and Oxidative Stress, Disruption of Calcium Homeostasis | Glioblastoma Multiforme is a highly lethal form of brain cancer, resistant to traditional therapeutic approaches and oftentimes hardly resectable. The application of pulsed electric fields (… |
| IRE | Petrella et al · IEEE Trans Biomed Eng | 2022 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Expanding the volume of an irreversible electroporation treatment typically necessitates an increase in pulse voltage, number, duration, or repetition. This study investigates the addition o… |
| ECT | Alkış et al · Journal of Molecular Structure | 2021 | In Vitro Study | Cell Culture | – | In this study, a new Schiff base ligand and its two M(II) complexes [CoCl·L(H2 O)2 ]·2H2 O, [RuCl(pcymene)L] were synthesized. The structural features were confirmed from their micro analytic… |
| Other EP | Lira et al · Adv Sci (Weinh) | 2021 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA) | Resealing of membrane pores is crucial for cell survival. Membrane surface charge and medium composition are studied as defining regulators of membrane stability. Pores are generated by elec… |
| ECT | Lopes et al · Med Eng Phys | 2021 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Electrochemotherapy (ECT) requires covering the entire tumor and safe margins with a suitable pulsed electric field (PEF). The PEF distribution depends on the biological and electrical param… |
| ECT | Szlasa et al · Int J Mol Sci | 2021 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation | Electroporation is influenced by the features of the targeted cell membranes, e.g., the cholesterol content and the surface tension of the membrane. The latter is eventually affected by the … |
| ECT | Yadegari-Dehkordi et al · Cell J | 2021 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Reversible Membrane Permeabilisation | Objective: The cell membrane is a major barrier for delivery of hydrophilic drugs and molecules into the cells. Although low voltage and high frequency electric fields (LVHF) are proposed to… |
| Gene ET | Kos · Pharmaceutics | 2021 | In Vitro Study | Cell Culture | Interleukin-12 Mediated Immune Stimulation, Gene Electrotransfer (Plasmid DNA) | Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such a… |
| IRE | Graybill et al · Annu Int Conf IEEE Eng Med Biol Soc | 2021 | In Vitro Study | Cell Culture | Increased Blood–Brain Barrier Permeability | Local disruption of the blood-brain barrier (BBB) by pulsed electric fields shows significant potential for treating neurological conditions. Microfluidic BBB models can provide low-cost, co… |
| IRE | Alinezhadbalalami et al · Bioelectrochemistry | 2021 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Expansion of cytotoxic T lymphocytes (CTLs) is a crucial step in almost all cancer immunotherapeutic methods. Current techniques for expansion of tumor-reactive CTLs present major limitation… |
| IRE | Hanson et al · Sci Rep | 2021 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is used clinically as a focal therapy to ablate solid tumors. A critical disadvantage of IRE as a monotherapy for cancer is the inability of ablating large… |
| IRE | Xu et al · J. Phys.: Conf. Ser. | 2021 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) uses non thermoelectric pulse to ablate tumours, which is an effective cancer treatment method. The pulse is transmitted through a minimally invasive needl… |
| ECT | Fiorentzis et al · J Vis Exp | 2020 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Optimisation of Pulse Parameters | Electrochemotherapy (ECT) is the combination of transient pore formation following electric pulse application with the administration of cytotoxic drugs, which enhances the cytotoxic effect … |
| Other EP | Nathamgari et al · Small | 2020 | In Vitro Study | Cell Culture | – | Introducing exogenous molecules into cells with high efficiency and dosage control is a crucial step in basic research as well as clinical applications. Here, the capability of the nanofount… |
| Other EP | Rems et al · Biophys J | 2020 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Transmembrane Potential Change | Pulsed electric fields are increasingly used in medicine to transiently increase the cell membrane permeability via electroporation to deliver therapeutic molecules into the cell. One type o… |
| Calcium EP | Szewczyk et al · Bioelectrochemistry | 2020 | In Vitro Study | Animal (In Vivo) | Apoptosis Induction, Calcium Electroporation and ATP Depletion | Calcium electroporation (CaEP) has been previously reported as an effective method of rhabdomyosarcoma cells reduction. CaEP causes temporary cell membrane permeabilization with simultaneous… |
| Other EP | Sözer et al · Biophys J | 2020 | In Vitro Study | Cell Culture | – | Although transport of molecules into cells via electroporation is a common biomedical procedure, its protocols are often based on trial and error. Despite a long history of theoretical effor… |
| Other EP | Wolff et al · Cancers (Basel) | 2020 | In Vitro Study | Cell Culture | Mitochondrial Dysfunction and Oxidative Stress, Reversible Membrane Permeabilisation | New approaches in oncotherapy rely on the combination of different treatments to enhance the efficacy of established monotherapies. Pulsed electric fields (PEFs) are an established method (e… |
| ECT | Youssef et al · Mathematics | 2020 | In Vitro Study | Cell Culture | Thermal Effect and Joule Heating | The essential target of the tumor’s treatment is how to destroy its tissues. This work is dealing with the thermal damage of the tumor tissue due to the thermoelectrical effect based on the … |
| IRE | Lv et al · IEEE Trans Biomed Eng | 2020 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Unlabelled: Irreversible electroporation (IRE) employs brief, high-electric field pulses to ablate tumors while preserving the extracellular matrix. Recently, we showed that combining short … |
| Gene ET | Polajžer et al · Sci Rep | 2020 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Pulsed electric field treatment has increased over the last few decades with successful translation from in vitro studies into different medical treatments like electrochemotherapy, irrevers… |
| IRE | Lv et al · Phys Med Biol | 2020 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a minimally invasive tumor therapy using pulsed electric field with high intensity while the important tissues such as blood vessel, bile duct, and nerv… |
| IRE | Polajzer et al · Radiol Oncol | 2020 | In Vitro Study | Cell Culture | Immunogenic Cell Death (ICD), Irreversible Pore Formation and Cell Death | Background Tumor cells can die via immunogenic cell death pathway, in which damage-associated molecular pattern molecules (DAMPs) are released from the cells. These molecules activate cells … |
| ECT | Brun et al · Bioelectrochemistry | 2019 | In Vitro Study | Cell Culture | Preservation of Extracellular Matrix and Tissue Scaffold | Electroporation of cells is usually studied using cell suspensions or monolayer cultures. 3D scaffolds for cell culture have been recently designed in order to reproduce in vitro the complex… |
| ECT | García-Sánchez et al · Bioelectrochemistry | 2019 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters, Tissue Conductivity and Impedance Change | In this study the evolution in the efficiency of electrochemotherapy (reversible electroporation) with pulse number was assessed in vitro. Experiments were performed using 100 μs pulses at d… |
| Other EP | He et al · Nano Lett | 2019 | In Vitro Study | Cell Culture | Apoptosis Induction | Downstream analysis of circulating tumor cells (CTCs) has provided new insights into cancer research. In particular, the detection of CTCs, followed by the regulation and monitoring of their… |
| ECT | Mączyńska et al · Oncol Rep | 2019 | In Vitro Study | Cell Culture | Increased Intracellular Cisplatin Accumulation, Potentiation of Cytotoxic Drug Permeability | Betulinic acid (BTA) is naturally occurring triterpene that has received interest as a novel therapeutic substance with cytotoxicity towards a number of cancer cell lines. Despite the wide s… |
| Other EP | Ruzgys et al · Sci Rep | 2019 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change, Transmembrane Potential Change | In this study we evaluated the influence of medium conductivity to propidium iodide (PI) and bleomycin (BLM) electroporation mediated transfer to cells. Inverse dependency between the extrac… |
| Other EP | Phonesouk et al · Materials (Basel) | 2019 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation | In the fields of biology and medicine, nanoproducts such as nanoparticles (NPs) are specifically interesting as theranostic tools, since they offer the double capacity to locally deliver act… |
| Other EP | Punjiya et al · Sci Rep | 2019 | In Vitro Study | Cell Culture | Thermal Effect and Joule Heating | Isolation of cells and their transfection in a controlled manner is an integral step in cell biotechnology. Electric field approaches such as dielectrophoresis (DEP) offers a more viable met… |
| Other EP | Tamra et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2019 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters | In this study, a microwave biosensor based on interdigitated electrode layout is evaluated as an on-chip electroporation system applicable to electroporation of adherent cell monolayers. The… |
| IRE | Ren et al · Int J Hyperthermia | 2019 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Electrode Geometry and Placement | Introduction: Irreversible electroporation (IRE) combined with a catheter-based electrode during endoscopy is a potential alternative treatment method for digestive tract tumors. The aim of … |
| Other EP | Lu et al · Onco Targets Ther | 2018 | In Vitro Study | Cell Culture | Apoptosis Induction, Electric Field Distribution and Modelling | Background: Pulsed electric field (PEF) has been considered as a cell permeability enhancing agent for cancer treatment. Nevertheless, application of PEF for conventional electrochemo-therap… |
| Other EP | Srimathveeravalli et al · Mol Imaging | 2018 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal… |
| Other EP | SUBRAMANI et al · Turk J Elec Eng & Comp Sci | 2018 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters | Pulsed electric field technology is an emerging nonthermal food processing method. PEF food processing requires a high voltage pulse generator that produces high intensive pulses to be deliv… |
| Calcium EP | Romeo et al · Technol Cancer Res Treat | 2018 | In Vitro Study | Cell Culture | Calcium Electroporation and ATP Depletion, Optimisation of Pulse Parameters | Reversible electroporation is used to increase the uptake of chemotherapeutic drugs in local tumor treatment (electrochemotherapy) by applying the pulsing protocol (8 rectangular pulses, 100… |
| Other EP | García-Sánchez et al · Biosens Bioelectron | 2018 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | This paper reports the comparative analysis, by means of electric impedance spectroscopy measurements, of three different cell lines subjected to electroporative pulses. The multifrequency i… |
| IRE | Yang et al · PLoS One | 2018 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | Purpose: The aim of this study was to develop a statistical model for cell death by irreversible electroporation (IRE) and to show that the statistic model is more accurate than the electric… |
| Other EP | Azan et al · Sci Rep | 2017 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | Confocal Raman microspectroscopy was used to study the interaction between pulsed electric fields and live cells from a molecular point of view in a non-invasive and label-free manner. Raman… |
| IRE | Bonakdar et al · RSC Adv | 2017 | In Vitro Study | Cell Culture | Increased Blood–Brain Barrier Permeability, Reversible Membrane Permeabilisation | Pulsed electric fields interact with the blood-brain barrier (BBB) and have been shown to increase the BBB permeability under some pulsing regimes. Pulsed electric fields may enhance drug de… |
| Other EP | Hanna et al · Stem Cell Res Ther | 2017 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | Background: Human mesenchymal stem cells are promising tools for regenerative medicine due to their ability to differentiate into many cellular types such as osteocytes, chondrocytes and adi… |
| IRE | Rajeckaitė et al · J Membr Biol | 2017 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | The aim of this study was to investigate the dependence of calcein extraction and cell viability on the parameters of pulsed electric field (PEF). Two different approaches concerning PEF par… |
| Other EP | Rezaee et al · Int J Nanomedicine | 2017 | In Vitro Study | Cell Culture | – | Background and objective: Radiation therapy (RT) is the gold standard treatment for more than half of known tumors. Despite recent improvements in RT efficiency, the side effects of ionizing… |
| IRE | Labarbera · Bioengineering (Basel) | 2017 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | One recent area of cancer research is irreversible electroporation (IRE). Irreversible electroporation is a minimally invasive procedure where needle electrodes are inserted into the body to… |
| IRE | Labarbera et al · Theor Biol Med Model | 2017 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change, Irreversible Pore Formation and Cell Death | Background: One recent area of cancer research is irreversible electroporation (IRE). Irreversible electroporation is a minimally invasive procedure where needle electrodes are inserted into… |
| Other EP | DiGiusto et al · Mol Ther Methods Clin Dev | 2016 | In Vitro Study | Cell Culture | – | Gene therapy for HIV-1 infection is a promising alternative to lifelong combination antiviral drug treatment. Chemokine receptor 5 (CCR5) is the coreceptor required for R5-tropic HIV-1 infec… |
| Other EP | Dovgan et al · J Membr Biol | 2016 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | New cryopreservation approaches for medically applicable cells are of great importance in clinical medicine. Current protocols employ the use of dimethyl sulfoxide (DMSO), which is toxic to … |
| ECT | Esmekaya et al · J Membr Biol | 2016 | In Vitro Study | Cell Culture | Increased Intracellular Cisplatin Accumulation, Potentiation of Cytotoxic Drug Permeability | Electrochemotherapy is the usage of electroporation to introduce chemotherapeutic drugs through membrane pores into target cells for cancer treatment. The effectiveness of chemotherapeutic d… |
| Other EP | Frandsen et al · J Membr Biol | 2016 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation | Electroporation-based treatments and other therapies that permeabilize the plasma membrane have been shown to be more devastating to malignant cells than to normal cells. In this study, we a… |
| Other EP | Guo et al · Sci Rep | 2016 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change, Electrode Geometry and Placement | This paper reports a novel microarray chip for in-situ, real-time and selective electroporation on individual cells integrated with cell positioning and impedance monitoring. An array of qua… |
| Other EP | Novickij et al · Sci Rep | 2016 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Electric Field Distribution and Modelling | Electroporation is a phenomenon occurring due to exposure of cells to Pulsed Electric Fields (PEF) which leads to increase of membrane permeability. Electroporation is used in medicine, biot… |
| Other EP | Tamošiūnas et al · J Membr Biol | 2016 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation | In this study, we aimed to determine whether the combination of electroporation (EP) and ultrasound (US) waves (sonoporation) can result in an increased intracellular delivery of anticancer … |
| Calcium EP | Zielichowska et al · Bioelectrochemistry | 2016 | In Vitro Study | Animal (In Vivo) | Apoptosis Induction, Calcium Electroporation and ATP Depletion | The electroporation (EP) supports various types of anticancer therapies by the selective transport of cytostatics. Increase in intracellular calcium level by EP may be a new approach to fibr… |
| Gene ET | Lesueur et al · Mol Ther Nucleic Acids | 2016 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA) | Gene electrotransfer is a safe and efficient nonviral technique for the transfer of nucleic acids of all sizes. Using a small reporter plasmid (3.5 kbp), electrotransfer of more than 90% of … |
| Other EP | Pasquet et al · Biochem Biophys Rep | 2016 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA) | Electric field mediated gene transfer is facing a problem in expression yield due to the poor transfer across the nuclear envelope. Trans-cyclohexane-1,2-diol (TCHD) was shown to significant… |
| Gene ET | Denzi et al · J Membr Biol | 2016 | In Vitro Study | Cell Culture | Potentiation of Cytotoxic Drug Permeability, Gene Electrotransfer (Plasmid DNA) | Over the past decades, the effects of ultrashort-pulsed electric fields have been used to investigate their action in many medical applications (e.g. cancer, gene electrotransfer, drug deliv… |
| IRE | Bonakdar et al · Biophys J | 2016 | In Vitro Study | Animal (In Vivo) | Increased Blood–Brain Barrier Permeability, Reversible Membrane Permeabilisation | The blood-brain barrier, mainly composed of brain microvascular endothelial cells, poses an obstacle to drug delivery to the brain. Controlled permeabilization of the constituent brain endot… |
| ECT | Landström et al · Anticancer Res | 2015 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | Aim: Electrochemotherapy (ECT) is a new cancer treatment modality that uses electroporation to potentiate chemotherapeutic agents, especially bleomycin. ECT causes both a direct toxic effect… |
| Gene ET | Madi et al · J Membr Biol | 2015 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | DNA electrotransfer is a successful technic for gene delivery. However, its use in clinical applications is limited since little is known about the mechanisms governing DNA electrotransfer i… |
| ECT | Zielichowska et al · Biomed Pharmacother | 2015 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Electric Field Distribution and Modelling | Introduction: Electroporation (EP) is commonly applied for effective drug transport thorough cell membranes based on the application of electromagnetic field. When applied with cytostatics, … |
| Other EP | Lojk et al · Bioelectromagnetics | 2015 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | Introduction of genetic material into muscle tissue has been extensively researched, including isolation and in vitro expansion of primary myoblasts as a potential source of cells for skelet… |
| Calcium EP | Frandsen et al · Biochim Biophys Acta | 2014 | In Vitro Study | Cell Culture | Calcium Electroporation and ATP Depletion, Increased Intracellular Bleomycin Accumulation | Background: Electroporation with calcium (calcium electroporation) can induce ATP depletion-associated cellular death. In the clinical setting, the cytotoxic drug bleomycin is currently used… |
| Gene ET | Garcia et al · PLoS One | 2014 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Electroporation-based therapies are powerful biotechnological tools for enhancing the delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs). Electrochemotherapy … |
| Other EP | Lekner · Phys Med Biol | 2014 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation | Electroporation in cancer therapy in which elongated micron-sized conductors are used to enhance an externally applied electric field is investigated. Such field enhancement was previously u… |
| ECT | Meulenberg et al · Toxicol In Vitro | 2014 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Electric Field Distribution and Modelling | The aim of this study was to develop an in vitro cell model for studying the in vivo observed vascular effect, induced by exposing blood vessels to changing electric field strengths. Human m… |
| Other EP | Rangel et al · J Membr Biol | 2014 | In Vitro Study | Cell Culture | – | Connexins are proteins that form gap junctions. Perturbations in the cell membrane reportedly promote changes in the expression profile of connexins. Electroporation promotes destabilization… |
| Other EP | Reigada · Biochim Biophys Acta | 2014 | In Vitro Study | Cell Culture | Potentiation of Cytotoxic Drug Permeability | Electroporation is the basis for the transfection of genetic material and for drug delivery to cells, including electrochemotherapy for cancer. By means of molecular dynamics many aspects of… |
| Gene ET | Guo et al · Mol Ther Methods Clin Dev | 2014 | In Vitro Study | Cell Culture | Nanosecond Pulsed Electric Field (nsPEF), Gene Electrotransfer (Plasmid DNA) | The impact of nanosecond pulsed electric fields (nsPEFs) on gene electrotransfer has not been clearly demonstrated in previous studies. This study was conducted to evaluate the influence of … |
| IRE | Colacino et al · Technol Cancer Res Treat | 2014 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Cellulose nanocrystals are rod-shaped, crystalline nanoparticles that have shown prom-ise in a number of industrial applications for their unique chemical and physical properties. However, i… |
| IRE | Jourabchi et al · Gastrointestinal Intervention | 2014 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a promising new minimally invasive modality for the ablation of solid tumors. Unlike the current leading thermal ablation modalities, such as radiofrequ… |
| ECT | Bagheri et al · J Biomed Phys Eng | 2013 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Antivascular Effect and Vessel Disruption | Unlabelled: Propose: Standard electroporation and electrochemotherapy caused the endothelial cell permeability and reduction in tumor blood flow. The effects of low voltage and high frequenc… |
| ECT | Gibot et al · J Control Release | 2013 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Electrochemotherapy (ECT) is a physical technique that allows cytotoxic molecules to be efficiently released in tumor cells by inducing transient cell plasma membrane permeabilization. The m… |
| IRE | Korohoda · Cell Mol Biol Lett | 2013 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Experiments on reversible and irreversible cell electroporation were carried out with an experimental setup based on a standard apparatus for horizontal electrophoresis, a syringe pump with … |
| ECT | Mansourian et al · Electromagn Biol Med | 2013 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters, Apoptosis Induction | Nowadays, due to the wide use of mobile phones, extensive studies have been carried out on the effects of magnetic field (MF) on public health. In this paper, we study the effect of 217 Hz M… |
| ECT | Shankayi et al · J Membr Biol | 2013 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | During standard electrochemotherapy (ECT), using a train of 1,000 V/cm amplitude rectangular pulses with 1 Hz frequency, patients experience an unpleasant sensation and slight edema. Accordi… |
| Other EP | Miklavčič et al · J Membrane Biol | 2013 | In Vitro Study | Cell Culture | – | TO SPECIAL ISSUE Introduction to Third Special Electroporation-Based Technologies and Treatments Issue Damijan Miklavčič • Lluis M. Mir • P. Thomas Vernier Published online: 20 September 2… |
| Other EP | Chabot et al · Pharmaceuticals (Basel) | 2013 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation | For more than a decade, understanding of RNA interference (RNAi) has been a growing field of interest. The potent gene silencing ability that small oligonucleotides have offers new perspecti… |
| Gene ET | Liew et al · Hum Gene Ther Methods | 2013 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA) | Mesenchymal stem cells (MSCs) are multipotent nonhematopoietic cells with the ability to differentiate into various specific cell types, thus holding great promise for regenerative medicine.… |
| Gene ET | Tesic et al · J Membr Biol | 2013 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA) | Development of recombinant DNA technologies has allowed us to create new delivery systems that target specific cell types and that can be used in gene therapy. One of these targets is vascul… |
| Other EP | García-Sánchez et al · Instrumentation viewpoint | 2013 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | Electroporation or electropermeabilization is a phenomenon observed when lipid bilayers, generally cell membranes, are exposed to high electric field pulses becoming transiently permeable to… |
| Other EP | Delemotte et al · J Membr Biol | 2012 | In Vitro Study | Cell Culture | Electric Field Distribution and Modelling | The permeability of cell membranes can be transiently increased following the application of external electric fields. Theoretical approaches such as molecular modeling provide a significant… |
| ECT | Escoffre et al · curr pharm des | 2012 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Treatment of recurrent or unresectable cutaneous and subcutaneaous tumors continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a palliative treatment of cutaneous and … |
| ECT | Ghiasi et al · Int J Biomed Sci | 2012 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Electrode Geometry and Placement | The Electrochemotherapy (ECT) is an effective treatment of cutaneous and subcutaneous solid tumors. Electric field is applied to tumor nodules to enhance the delivery/distribution of a non-p… |
| IRE | Kaminska et al · Gen Physiol Biophys | 2012 | In Vitro Study | Cell Culture | Apoptosis Induction, Reversible Membrane Permeabilisation | Application of a high electric field causes an electric shock to the heart. This is utilized in defibrillation to reestablish normal contraction rhythms during dangerous arrhythmias or in ca… |
| Other EP | Raeisi et al · J Membr Biol | 2012 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | This study investigated whether molecules spontaneously transported inside cells, like glucose derivatives, can also be used as electropermeabilization markers. Uptake of a fluorescent deoxy… |
| Other EP | Towhidi et al · Radiol Oncol | 2012 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters | Background: The cell membrane acts as a barrier that hinders free entrance of most hydrophilic molecules into the cell. Due to numerous applications in medicine, biology and biotechnology, t… |
| Other EP | Chabot et al · Mol Ther | 2012 | In Vitro Study | Cell Culture | – | Micro-RNAs (miRNAs) are small regulatory RNAs that play an important role in disease development and progression and therefore represent a potential new class of therapeutic targets. However… |
| Undetermined | Chopinet et al · Int J Pharm | 2012 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA), Optimisation of Pulse Parameters | Electro-gene-therapy is a promising technique for cancer treatment. However, knowledge about mechanism of gene transfer with electric field in tumor is limited. Whereas in vitro electrotrans… |
| Other EP | Okeyo et al · The Proceedings of the Symposium on Micro-Nano Science and Technology | 2012 | In Vitro Study | Cell Culture | – | An electroporation device comprising an orifice sheet with regularly spaced micron size orifices for electric field constriction was developed and utilized to electropolate adherent HeLa cel… |
| IRE | Arena et al · Biophys J | 2012 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | Irreversible electroporation (IRE) is emerging as a powerful tool for tumor ablation that utilizes pulsed electric fields to destabilize the plasma membrane of cancer cells past the point of… |
| IRE | Xiong et al · J Cancer Res Ther | 2012 | In Vitro Study | Cell Culture | Apoptosis Induction, Irreversible Pore Formation and Cell Death | Background: High-voltage electric field pulses can make cell membrane electroporated irreversibly and eliminate malignant cells via necrosis. However, low-voltage is not efficient as that. A… |
| Other EP | Pakhomova · PLoS One | 2011 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters, Reversible Membrane Permeabilisation | Background: Electroporation is a method of disrupting the integrity of cell membrane by electric pulses (EPs). Electrical modeling is widely employed to explain and study electroporation, bu… |
| Other EP | Skolucka et al · Asian Pac J Trop Biomed | 2011 | In Vitro Study | Cell Culture | Mitochondrial Dysfunction and Oxidative Stress | Objective: To estimate electroporation (EP) influence on malignant and normal cells. Methods: Two cell lines including human malignant melanoma (Me-45) and normal human gingival fibroblast (… |
| Other EP | Troszak et al · PLoS One | 2011 | In Vitro Study | Cell Culture | Electric Field Distribution and Modelling | Electroporation, the permeabilization of the cell membrane lipid bilayer due to a pulsed electric field, has important implications in the biotechnology, medicine, and food industries. Tradi… |
| Other EP | Joergensen et al · Oligonucleotides | 2011 | In Vitro Study | Cell Culture | Potentiation of Cytotoxic Drug Permeability, Optimisation of Pulse Parameters | Electroporation is potentially a very powerful technique for both in vitro cellular and in vivo drug delivery, particularly relating to oligonucleotides and their analogs for genetic therapy… |
| ECT | Lambreva et al · Bioelectrochemistry | 2010 | In Vitro Study | Cell Culture | – | Two reliable methods have been combined: i) the electroporation of the cell membranes for facilitating the sensitizer incorporation into hystiocytic human lymphoma cells U-937 and (ii) the p… |
| IRE | Golberg et al · Biomed Eng Online | 2010 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: Irreversible electroporation (IRE) is a minimally invasive tissue ablation technique which utilizes electric pulses delivered by electrodes to a targeted area of tissue to produc… |
| ECT | Choi et al · Anal Chem | 2009 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Electric Field Distribution and Modelling | A microfabricated cell-based testing device for electrochemotherapy (ECT) has been developed; it mimics a clinical electroporator with a circular needle array and maintains a similar electri… |
| Other EP | Golzio et al · Biophysical Journal | 2009 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation | This publication has no abstract. |
| Other EP | Labanauskienė et al · Medicina | 2009 | In Vitro Study | Cell Culture | – | The aim of our study was to determine if electroporation could improve the efficacy of photodynamic tumor therapy. A disadvantage of photodynamic therapy is a slow and in some cases insuffic… |
| ECT | Tabassum et al · Spectrochim Acta A Mol Biomol Spectrosc | 2009 | In Vitro Study | Cell Culture | – | The homodinuclear C(16)H(30)N(8)O(5)Sn(2)Cl(4) (1), heterotetranuclear C(16)H(38)N(8)O(9)Sn(2)Cu(2)Cl(8) (2) and C(16)H(38)N(8)O(9)Sn(2)Mn(2)Cl(8) (3) macrocyclic complexes were synthesized … |
| Other EP | Ušaj et al · Radiology and Oncology | 2009 | In Vitro Study | Cell Culture | – | Cell size dynamics and viability of cells exposed to hypotonic treatment and electroporation for electrofusion optimizationBackground. Various electrofusion parameters have to be adjusted to… |
| Gene ET | Wasungu et al · Int J Pharm | 2009 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | Electropermeabilization is a physical method to deliver molecules into cells and tissues. Clinical applications have been successfully developed for antitumoral drug delivery and clinical tr… |
| IRE | Shafiee et al · J Biomech Eng | 2009 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Thermal Effect and Joule Heating | Intense but short electrical fields can increase the permeability of the cell membrane in a process referred to as electroporation. Reversible electroporation has become an important tool in… |
| Other EP | Böckmann et al · Biophys J | 2008 | In Vitro Study | Cell Culture | Electric Field Distribution and Modelling | Membrane electroporation is the method to directly transfer bioactive substances such as drugs and genes into living cells, as well as preceding electrofusion. Although much information on t… |
| Other EP | He et al · Bioelectrochemistry | 2008 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Tissue Conductivity and Impedance Change | This paper presents a novel method to measure the dynamic process of membrane permeability during electroporation (EP) on microchips for human cancer cells. Micro EP chips with three-dimensi… |
| Other EP | Kandušer et al · Bioelectrochemistry | 2008 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | Cell membrane permeabilization is caused by the application of high intensity electric pulses of short duration. The extent of cell membrane permeabilization depends on electric pulse parame… |
| ECT | Choi et al · Biomed Microdevices | 2008 | In Vitro Study | Cell Culture | Electric Field Distribution and Modelling, Increased Intracellular Bleomycin Accumulation | A microfabricated cell-based testing device for electrochemotherapy (ECT) has been developed by miniaturizing the widely used clinical electroporator with a two-needle array into two-dimensi… |
| Other EP | Koda et al · Langmuir | 2008 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA) | Gene transfection into adherent cells from plasmid DNA (pDNA)-arrayed substrates known as gene transfection arrays appears to be a promising tool for the high-throughput analysis of gene fun… |
| Other EP | MacQueen et al · Bioelectrochemistry | 2008 | In Vitro Study | Cell Culture | Electric Field Distribution and Modelling, Optimisation of Pulse Parameters | We report the use of dielectrophoresis (DEP) to position U-937 monocytes within a non-uniform electric field, prior to electroporation (EP) for gene delivery. DEP positioning and EP pulsing … |
| Other EP | Anon · Molecular Therapy | 2007 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA) | Ultrasound-mediatedtransient membrane poration or sonoporation represents a promising means of non-invasively achieving targeted gene transfer in vivo. Sonoporation events are enhanced by th… |
| Other EP | Bicek et al · Bioelectrochemistry | 2007 | In Vitro Study | Cell Culture | – | Ruthenium complex NAMI-A [ImH][trans-RuCl(4)(DMSO-S)Im] (Im = imidazole) is a potential chemotherapeutic drug in cancer treatment. Electroporation can be used to facilitate delivery of NAMI-… |
| Other EP | Pavlin et al · Biochim Biophys Acta | 2007 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Transmembrane Potential Change | Electroporation is a process where increased permeability of cells exposed to an electric field is observed. It is used in many biomedical applications including electrogene transfection and… |
| Other EP | Pliquett et al · IEEE Trans Biomed Eng | 2007 | In Vitro Study | Cell Culture | Potentiation of Cytotoxic Drug Permeability, Electrode Geometry and Placement | Electrical creation of aqueous pathways across the skin's outer layer [stratum corneum (SC)] provides an approach to transdermal delivery of medium-size water-soluble compounds. However, ner… |
| Other EP | Pucihar et al · Eur Biophys J | 2007 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Transmembrane Potential Change | This paper investigates the influence of cell density on cell membrane electropermeabilization. The experiments were performed on dense cell suspensions (up to 400 x 10(6) cells/ml), which r… |
| Other EP | Xu et al · Bioelectrochemistry | 2007 | In Vitro Study | Cell Culture | – | In this paper, it was reported for the first time that the combination of the electroporation and the conjugation of the TiO(2) nanoparticles with the monoclonal antibody could improve the p… |
| Gene ET | Čorović et al · Biomed Eng Online | 2007 | In Vitro Study | Cell Culture | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Background: Electrochemotherapy and gene electrotransfer are novel promising treatments employing locally applied high electric pulses to introduce chemotherapeutic drugs into tumor cells or… |
| Gene ET | Reberšek et al · Biomed Eng Online | 2007 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA), Reversible Membrane Permeabilisation | Background: Gene electrotransfer is a non-viral method used to transfer genes into living cells by means of high-voltage electric pulses. An exposure of a cell to an adequate amplitude and d… |
| Other EP | Kanthou et al · Mol Cancer Ther | 2006 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA), Antivascular Effect and Vessel Disruption | Electroporation-based therapies, such as electrochemotherapy and electrogene therapy, result in the disruption of blood vessel networks in vivo and cause changes in blood flow and vascular p… |
| ECT | Miklavcic et al · European Journal of Cancer Supplements | 2006 | In Vitro Study | Cell Culture | – | This publication has no abstract. |
| Other EP | Lu et al · Biosens Bioelectron | 2006 | In Vitro Study | Cell Culture | Electrode Geometry and Placement | Microfabricated devices for cell lysis have demonstrated many advantages over conventional approaches. Among various design of microdevices that employ electroporation for cytolysis, most ut… |
| Other EP | Pavlin et al · Biophys J | 2005 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change | An increased permeability of a cell membrane during the application of high-voltage pulses results in increased transmembrane transport of molecules that otherwise cannot enter the cell. Inc… |
| IRE | Miller et al · Technol Cancer Res Treat | 2005 | In Vitro Study | Cell Culture | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | In this study we perform in vitro irreversible electroporation (IRE) experiments with human hepatocarcinoma cells (HepG2) to investigate IRE as a new technique for undesirable tissue ablatio… |
| Other EP | Pavlin et al · Biophys J | 2003 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | During the electroporation cell membrane undergoes structural changes, which increase the membrane conductivity and consequently lead to a change in effective conductivity of a cell suspensi… |
| Gene ET | Cemazar et al · DNA Cell Biol | 2003 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA), Increased Intracellular Cisplatin Accumulation | The aim of our study was to evaluate electrogenetherapy with p53wt alone or combined with cisplatin on two colorectal (HT-29 and LoVo) and two prostatic (PC-3 and Du145) carcinoma cell lines… |
| Other EP | Krassowska et al · Ann Biomed Eng | 2003 | In Vitro Study | Cell Culture | Optimisation of Pulse Parameters, Electrode Geometry and Placement | The goal of this study was to collect a comprehensive set of data that related lethal effects of electric fields to the duration of the pulse. Electric pulses of different strengths and dura… |
| ECT | Pucihar et al · Bioelectrochemistry | 2002 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | Electrochemotherapy is a technique where electric pulses in combination with chemotherapeutic agents are applied to tumor cells. In general, patients find electrochemotherapy tolerable, in s… |
| ECT | Jaroszeski et al · Anticancer Drugs | 2000 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Electroporation is a physical event that temporarily reduces cell membrane barrier properties. Diminished membrane barrier properties are achieved by exposing cells to pulsed electric fields… |
| Other EP | Neumann et al · Bioelectrochemistry | 2000 | In Vitro Study | Cell Culture | Electrode Geometry and Placement | Electrochemical microelectrode devices are among the great challenges for bioelectrochemistry, cell biology and recently also for biomedical research and new clinical electrotherapies. Two r… |
| Other EP | Zewert et al · Bioelectrochem Bioenerg | 1999 | In Vitro Study | Cell Culture | Potentiation of Cytotoxic Drug Permeability | A combined electrical (HV, "high voltage", pulsing) and chemical (topical sodium thiosulfate) intervention is hypothesized to create enlarged aqueous pathways that allow large quantities of … |
| Other EP | Lebar et al · Electro- and Magnetobiology | 1998 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | The effect of applied electrical energy on cell survival and permeabi-lization of the plasma membrane under in vitro conditions were examined. Cell viability was measured with a colony-formi… |
| Other EP | Ĉemazˆr et al · Electro- and Magnetobiology | 1998 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation | Electropermeabilization (electroporation) is a technique widely used to introduce various membrane-impermeable molecules into cells in vitro or in vivo. In this study we determined the effec… |
| ECT | Jaroszeski et al · Adv Drug Deliv Rev | 1997 | In Vitro Study | Cell Culture | Potentiation of Cytotoxic Drug Permeability, Increased Intracellular Bleomycin Accumulation | The combined treatment consisting of a chemotherapeutic agent and pulsed electric fields has been termed electrochemotherapy. This relatively new treatment modality relies on the physical ef… |
| Other EP | T Kalinski, K Jaquet, R Langen, L Wang, H Gabbert, C Gerharz · Biotechnology Techniques | 1997 | In Vitro Study | Cell Culture | Gene Electrotransfer (Plasmid DNA) | Transfection as a method for the introduction of nucleic acids into eukaryotic cells is an important tool for functional investigations of genes not expressed or mutated in target cells. Sev… |
| Other EP | Anon · Progress in Biophysics and Molecular Biology | 1996 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change | C 1 Transmembrane signalling and transduction P-cl45 P-Cl-46 REGULATORY ROLE OF THE MBMBRANE POTENTIAL ON THE ACTIVATION STRUCTURAL AND ELECTRICAL PROPERTIES OF SUPPORTED LIPID FILMS BY IMPE… |
| Other EP | Pliquett et al · Bioelectrochemistry and Bioenergetics | 1996 | In Vitro Study | Cell Culture | – | The stratum comeum (SC) of mammalian skin is a formidable barrier to the transport of both small ions and charged molecules, but large, very rapid increases in transport can be created by "h… |
| Other EP | Sharma et al · Biophys J | 1996 | In Vitro Study | Cell Culture | Transmembrane Potential Change | The effect of a nontoxic, nonionic block co-polymeric surface active agent, poloxamer 188, on electroporation of artificial lipid membranes made of azolectin, was investigated. Two different… |
| ECT | Mir et al · Bioelectrochemistry and Bioenergetics | 1995 | In Vitro Study | Cell Culture | – | Short and intense electric pulses (EP) are regularly used in almost all molecular and cellular biology laboratories to introduce foreign DNA, as well as other exogeneous molecules, into livi… |
| Other EP | Prausnitz et al · Biophys J | 1995 | In Vitro Study | Cell Culture | – | Electroporation involves the application of an electric field pulse that creates transient aqueous pathways in lipid bilayer membranes. Transport through these pathways can occur by differen… |
| Other EP | Vanbever et al · Bioelectrochemistry and Bioenergetics | 1995 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Potentiation of Cytotoxic Drug Permeability | Electroporation, i.e. the creation of transient enhanced lipid membrane permeability using high intensity electric field pulses, can be used to promote transdermal drug delivery. Compared wi… |
| Other EP | Lopes et al · IEEE Trans. Instrum. Meas. | 2026 | In Silico / Modelling | Computational Model | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Electroporation (EP)–based cancer therapies, such as electrochemotherapy (ECT) and irreversible electroporation (IRE), require accurate characterization of tissue electrical properties to pr… |
| ECT | Borbála Fülöp et al · J Theor Biol | 2026 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | Electroporation-based therapies such as electrochemotherapy (ECT) hold a great promise for improving cancer treatments. While highly effective for superficial tumours, its application for de… |
| Other EP | Leschiera et al · Bioelectrochemistry | 2026 | In Silico / Modelling | Computational Model | Immunogenic Cell Death (ICD) | Electroporation is increasingly used as a percutaneous ablation technique for tumours located near vital structures. Although effective, tumour regrowth may still occur. At the same time, in… |
| IRE | Miklavcic et al · Radiol Oncol | 2026 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Potentiation of Cytotoxic Drug Permeability | Background: Electroporation-Based Treatments and Therapies (EBTTs) - electrochemotherapy, irreversible electroporation, pulsed field ablation, and gene electro-transfer - use short, high-vol… |
| ECT | Vélez Salazar et al · Front Bioinform | 2026 | In Silico / Modelling | Computational Model | Potentiation of Cytotoxic Drug Permeability, Vascular Lock Effect | Drug administration via the bloodstream involves some transport and reaction mechanisms ( R T M s ), such as extravasation, perfusion along blood vessels, transmembrane and interstitial tran… |
| ECT | Bernardini et al · COMPEL - The international journal for computation and mathematics in electrical and electronic engineering | 2026 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling | Purpose This study aims to present a numerical model to predict the electric field distribution in the presence of conductive or dielectric nanoparticles close to the cell membrane during el… |
| IRE | Chen et al · IEEE Trans Biomed Eng | 2026 | In Silico / Modelling | Computational Model | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | Objective: Asymmetric pulse waveforms represent an optimized treatment protocol for high-frequency irreversible electroporation (H-FIRE), offering a lower ablation threshold compared to symm… |
| IRE | Cheng et al · Ann Biomed Eng | 2026 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Tissue Conductivity and Impedance Change | Irreversible electroporation (IRE) is a minimally invasive, non-thermal, and cell-selective technique. When combined with the noninvasive nature of contact electrodes, they hold great promis… |
| IRE | Desier et al · Comput Methods Programs Biomed | 2026 | In Silico / Modelling | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Objective: Irreversible electroporation (IRE) represents a promising non-thermal ablation modality for the treatment of deep-seated tumors. However, its clinical efficacy is critically depen… |
| IRE | Jordan-Diaz et al · 2026 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) | 2026 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | Irreversible electroporation (IRE) is a non-thermal ablation technique used for the treatment of soft tissue tumors when thermal ablation is not feasible. Treatment outcome depends on tissue… |
| ECT | Salazar et al · Comput Biol Med | 2025 | In Silico / Modelling | Computational Model | Vascular Lock Effect | The systemic administration of chemotherapeutic drugs involves some reaction and transport mechanisms (RTMs), including perfusion along the blood vessels, extravasation, lymphatic drainage, … |
| ECT | Skorupska et al · Biosens Bioelectron | 2025 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling | We describe a novel lab-on-a-chip microsystem for cells electroporation, which can be used in studies comparing the effectiveness of two anti-cancer procedures. Our device in which we can si… |
| ECT | Vélez · PLoS One | 2025 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling | Using in-house computational tools, this work focuses on investigating how the combination of the electric field magnitude (E), bloodstream velocity (λinl) and pharmaco-kinetic profile (PK) … |
| IRE | Matkulcik et al · Int J Hyperthermia | 2025 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: Intraluminal irreversible electroporation (IRE) can be used for recanalizing occluded metal stents. However, optimal IRE parameters for consistent effects across different stent … |
| PFA | Batista Napotnik et al · Sci Rep | 2024 | In Silico / Modelling | Computational Model | Disruption of Calcium Homeostasis, Reversible Membrane Permeabilisation | Electric pulses used in electroporation-based treatments have been shown to affect the excitability of muscle and neuronal cells. However, understanding the interplay between electroporation… |
| Other EP | Fang et al · IEEE Trans. Instrum. Meas. | 2024 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | Radiofrequency ablation (RFA) is an energy-based tumor ablation modality that heats tissues by delivering radiofrequency current. The tissue properties of both electrical and thermal conduct… |
| Calcium EP | Jacobs IV et al · Bioelectrochemistry | 2024 | In Silico / Modelling | Computational Model | Thermal Effect and Joule Heating, Calcium Electroporation and ATP Depletion | The relationships between burst number, reversible, irreversible, and calcium electroporation have not been comprehensively evaluated in tumor tissue-mimics. Our findings indicate that elect… |
| Other EP | Kougkolos et al · J Control Release | 2024 | In Silico / Modelling | Computational Model | Potentiation of Cytotoxic Drug Permeability, Electric Field Distribution and Modelling | Skin electroporation for drug delivery involves the application of Pulsed Electric Fields (PEFs) on the skin to disrupt its barrier function in a temporary and non-invasive manner, increasin… |
| Other EP | Baker et al · IEEE Trans Biomed Eng | 2024 | In Silico / Modelling | Computational Model | – | Self-consistent evaluations of membrane electroporation along with local heating in single spherical cells arising from external AC radiofrequency electrical stimulation have been carried ou… |
| Other EP | He · Gels | 2024 | In Silico / Modelling | Computational Model | – | Silicone gel, used in the packaging of high-voltage, high-power semiconductor devices, generates bubbles during the packaging process, which accelerates the degradation of its insulation pro… |
| Other EP | Liu et al · IEEE Trans. Dielect. Electr. Insul. | 2024 | In Silico / Modelling | Computational Model | Potentiation of Cytotoxic Drug Permeability, Electric Field Distribution and Modelling | In the field of biomedicine, electroporation-mediated intracellular drug delivery is becoming increasingly popular due to its high efficiency and accuracy. In order to assess the therapeutic… |
| Other EP | Liu et al · IEEE Trans. Dielect. Electr. Insul. | 2024 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Tissue Conductivity and Impedance Change | In the study of electroporation, the conductivity of the cell membrane is a crucial factor in assessing the permeability of cell membrane. In previous research, the oversimplified equivalent… |
| Other EP | Paffi et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2024 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Purpose of this work is to develop a tool for electrochemotherapy treatment planning, which automatically estimates the optimal electrode configuration on the basis of the calculation of the… |
| Other EP | Zhang et al · Bioelectrochemistry | 2024 | In Silico / Modelling | Computational Model | Nanosecond Pulsed Electric Field (nsPEF) | Electroporation (EP) of the normal cell and cancer cell both in single-cell and multicellular models was investigated by the meshed transport network method (MTNM) in this paper. The simulat… |
| Other EP | Lv et al · Journal of Applied Physics | 2024 | In Silico / Modelling | Computational Model | – | Electroporation technique induced by high-voltage pulses has been successfully used to ablate tumor cells while preserving the function of normal blood vessels. Generally, the tumor blood ve… |
| IRE | Fesmire et al · IEEE Trans Biomed Eng | 2024 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Objective: This study sought to investigate a novel strategy using temperature-controlled delivery of nanosecond pulsed electric fields as an alternative to the 50-100 microsecond pulses use… |
| IRE | González-Suárez et al · Biomed Eng Lett | 2024 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Purpose: Pulsed electrical field (PEF) ablation is an energy-based technique used to treat a range of cancers by irreversible electroporation (IRE). Our objective was to use computational an… |
| IRE | Lakshmi Narasimhan et al · Applied Mathematical Modelling | 2024 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | In this paper, we develop surrogate models that can replace expensive predictive models and account for uncertainties in real-time treatment planning for irreversible electroporation of live… |
| ECT | Fülöp et al · – | 2023 | In Silico / Modelling | Computational Model | Potentiation of Cytotoxic Drug Permeability | Electrophoresis facilitated cancer treatment has demonstrated experimental efficacy in enhancing drug delivery within vascularised tumours. However, the lack of realistic mathematical models… |
| PFA | Scuderi et al · Biomolecules | 2023 | In Silico / Modelling | Computational Model | Optimisation of Pulse Parameters, Electric Field Distribution and Modelling | Electroporation is a biophysical phenomenon involving an increase in cell membrane permeability to molecules after a high-pulsed electric field is applied to the tissue. Currently, electropo… |
| ECT | Salazar et al · Med Biol Eng Comput | 2023 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Vascular Lock Effect | Reversible electroporation is a suitable technique to aid the internalization of medicaments in cancer tissues without inducing permanent cellular damage, allowing the enhancement of cytotox… |
| Other EP | Gabay et al · Ann Biomed Eng | 2023 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Molecular sampling with vacuum-assisted tissue electroporation is a novel, minimally invasive method for molecular profiling of solid lesions. In this paper, we report on the design of the b… |
| IRE | Perera-Bel et al · IEEE Trans Biomed Eng | 2023 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | Unlabelled: Tissue electroporation is the basis of several therapies. Electroporation is performed by briefly exposing tissues to high electric fields. It is generally accepted that electrop… |
| IRE | Lakshmi Narasimhan et al · Med Phys | 2023 | In Silico / Modelling | Computational Model | Tissue Conductivity and Impedance Change, Irreversible Pore Formation and Cell Death | Background: Electroporation-based cancer treatments are minimally invasive, nonthermal interventional techniques that leverage cell permeabilization to ablate the target tumor. However, the … |
| Other EP | Vale et al · J. Microw. Optoelectron. Electromagn. Appl. | 2022 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling | This study presents a rigorous numerical analysis of the current in the cell membrane, subjected to a uniform electric field, and its impact in the pore formation. The numerical model consid… |
| ECT | Vélez Salazar et al · Computers & Mathematics with Applications | 2022 | In Silico / Modelling | Computational Model | Increased Intracellular Cisplatin Accumulation | Electroporation has become an important technique in cancer treatment to induce the drug internalization into cells by applying controlled electric pulses. In the present work, the simulatio… |
| Gene ET | Potočnik et al · Applied Sciences | 2022 | In Silico / Modelling | Computational Model | Optimisation of Pulse Parameters, Gene Electrotransfer (Plasmid DNA) | Gene electrotransfer (GET) is a widely used method for nucleic acids’ delivery into cells. We explored, evaluated, and demonstrated the potential use of different pulse durations for introdu… |
| IRE | Perera-Bel et al · IEEE Trans Biomed Eng | 2022 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Objective: Irreversible electroporation (IRE) is a non-thermal tissue ablation therapy which is induced by applying high voltage waveforms across electrode pairs. When multiple electrode pai… |
| IRE | Khorasani · Electromagn Biol Med | 2022 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | The primary purpose of cancer treatment with irreversible electroporation (IRE) is to maximize tumor damage and minimize surrounding healthy tissue damage. Finite element analysis is one of … |
| Gene ET | Marino et al · Sci Rep | 2021 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Electroporation (EP), the increase of cell membrane permeability due to the application of electric pulses, is a universal phenomenon with a broad range of applications. In medicine, some of… |
| ECT | Goldberg et al · Bioelectrochemistry | 2021 | In Silico / Modelling | Computational Model | Increased Intracellular Cisplatin Accumulation | The use of electrochemotherapy (ECT) is a well-established technique to increase the cellular uptake of cytotoxic agents within certain cancer treatment strategies. The study of the mechanis… |
| Other EP | Khaorasani · fbt | 2021 | In Silico / Modelling | Computational Model | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Electric field intensity at each point is responsible for pore creation in the cell membrane during the electroporation process. These pores can increase the tissue electrical conductivity i… |
| Other EP | Khorasani · fbt | 2021 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Purpose: In the electroporation we can use different electrode types such as needle and plate electrode with different arrangements. One of the new electrode types is single bipolar electrod… |
| IRE | Aycock et al · IEEE Trans Biomed Eng | 2021 | In Silico / Modelling | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Unlabelled: High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay (d 1 )-negative phas… |
| Calcium EP | Navickaite et al · Pharmaceutics | 2020 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Transmembrane Potential Change | Electroporation-a transient electric-field-induced increase in cell membrane permeability-can be used to facilitate the delivery of anticancer drugs for antitumour electrochemotherapy. In re… |
| Other EP | Chiapperino et al · IEEE Trans Biomed Eng | 2020 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | In this article, the reversible electroporation induced by rectangular long unipolar and short bipolar voltage pulses on 3D cells is studied. The cell geometry was reconstructed from 3D imag… |
| IRE | Zhao et al · Applied Physics Letters | 2020 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Cell death mediated by non-thermal mechanisms is an essential characteristic of irreversible electroporation for tumor ablation. However, needle electrodes inherently promote thermal damage … |
| Other EP | Zhao et al · Applied Physics Letters | 2020 | In Silico / Modelling | Computational Model | – | This publication has no abstract. |
| IRE | Hogenes et al · Sci Rep | 2020 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | The final ablation zone created with irreversible electroporation (IRE) depends on the size, shape and strength of the electric field that is influenced by several parameters. A profound und… |
| Gene ET | Forjanič et al · IEEE Trans Biomed Eng | 2019 | In Silico / Modelling | Computational Model | Gene Electrotransfer (Plasmid DNA), Electric Field Distribution and Modelling | Objective: Skin is an attractive target tissue for gene transfer due to its size, accessibility, and its immune competence. One of the promising delivery methods is gene delivery by means of… |
| IRE | Gallinato et al · Phys Med Biol | 2019 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | The paper provides a numerical workflow, based on the 'real-life' clinical workflow of irreversible electroporation (IRE) performed for the treatment of deep-seated liver tumors. Thanks to a… |
| ECT | Berkenbrock et al · J Healthc Eng | 2018 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Electrochemotherapy is an anticancer treatment based on applying electric field pulses that reduce cell membrane selectivity, allowing chemotherapy drugs to enter the cells. In parallel to e… |
| Other EP | Lyu et al · Sci Rep | 2018 | In Silico / Modelling | Computational Model | – | It was recently shown that electrolysis may play a substantial detrimental role in microfluidic electroporation. To overcome this problem, we have developed a non-electrolytic micro/nano ele… |
| Other EP | Sweeney et al · Technol Cancer Res Treat | 2018 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | Electroporation is the process by which applied electric fields generate nanoscale defects in biological membranes to more efficiently deliver drugs and other small molecules into the cells.… |
| Gene ET | Forjanič et al · Biomed Eng Online | 2018 | In Silico / Modelling | Computational Model | Gene Electrotransfer (Plasmid DNA), Electric Field Distribution and Modelling | Background: The efficiency of gene electrotransfer, an electroporation-based method for delivery of pDNA into target tissues, depends on several processes. The method relies on application o… |
| Other EP | Mescia et al · IEEE Trans Biomed Eng | 2018 | In Silico / Modelling | Computational Model | Transmembrane Potential Change, Electric Field Distribution and Modelling | During the past decades, the poration of cell membrane induced by pulsed electric fields has been widely investigated. Since the basic mechanisms of this process have not yet been fully clar… |
| IRE | Zhao et al · Biomed Eng Online | 2018 | In Silico / Modelling | Computational Model | Tissue Conductivity and Impedance Change, Irreversible Pore Formation and Cell Death | Background: Irreversible electroporation (IRE) therapy relies on pulsed electric fields to non-thermally ablate cancerous tissue. Methods for evaluating IRE ablation in situ are critical to … |
| IRE | Zhao et al · IEEE Trans Biomed Eng | 2018 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | Unlabelled: For irreversible-electroporation (IRE)-based therapies, the underlying electric field distribution in the target tissue is influenced by the electroporation-induced conductivity … |
| Other EP | Bernardis et al · Open Physics | 2017 | In Silico / Modelling | Computational Model | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | In clinical treatments of a class of tumors, e . g . skin tumors, the drug uptake of tumor tissue is helped by means of a pulsed electric field, which permeabilizes the cell membranes. This … |
| IRE | Yang et al · Volume 3: Biomedical and Biotechnology Engineering | 2017 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Thermal Effect and Joule Heating | The aim of this study was to analyze five factors that are responsible for the ablation volume and maximum temperature during the procedure of irreversible electroporation (IRE). The five fa… |
| Other EP | Langus et al · Sci Rep | 2016 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Optimisation of Pulse Parameters | In silico experiments (numerical simulations) are a valuable tool for non-invasive research of the influences of tissue properties, electrode placement and electric pulse delivery scenarios … |
| IRE | Murovec et al · Biophys J | 2016 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | Many approaches for studying the transmembrane potential (TMP) induced during the treatment of biological cells with pulsed electric fields have been reported. From the simple analytical mod… |
| Other EP | Bhonsle et al · Biomed Eng Online | 2015 | In Silico / Modelling | Computational Model | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Background: For electroporation-based therapies, accurate modeling of the electric field distribution within the target tissue is important for predicting the treatment volume. In response t… |
| Other EP | Corovic et al · PLoS One | 2015 | In Silico / Modelling | Computational Model | Gene Electrotransfer (Plasmid DNA), Electric Field Distribution and Modelling | Vascular endothelium selectively controls the transport of plasma contents across the blood vessel wall. The principal objective of our preliminary study was to quantify the electroporation-… |
| IRE | Bonakdar et al · IEEE Trans Biomed Eng | 2015 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Tissue Conductivity and Impedance Change | Significance: Irreversible electroporation (IRE) is gaining popularity as a focal ablation modality for the treatment of unresectable tumors. One clinical limitation of IRE is the absence of… |
| IRE | Dermol et al · J Membr Biol | 2015 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Electrode Geometry and Placement | Electroporation is a phenomenon used in the treatment of tumors by electrochemotherapy, non-thermal ablation with irreversible electroporation, and gene therapy. When treating patients, eith… |
| Other EP | Becker et al · Math Biosci | 2014 | In Silico / Modelling | Computational Model | Potentiation of Cytotoxic Drug Permeability | In this study we consider the physics underlying electroporation which is administered to skin in order to radically increase transdermal drug delivery. The method involves the application o… |
| Other EP | Kasimova et al · Biophysical Journal | 2014 | In Silico / Modelling | Computational Model | – | This publication has no abstract. |
| Other EP | David et al · Annu Int Conf IEEE Eng Med Biol Soc | 2014 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling | Electric fields delivered across biological cells can cause structural and functional changes to the cell membrane, such as electroporation. An important application of electroporation is in… |
| IRE | Dermol et al · Bioelectrochemistry | 2014 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | High voltage electric pulses cause electroporation of the cell membrane. Consequently, flow of the molecules across the membrane increases. In our study we investigated possibility to predic… |
| IRE | Kurata et al · International Journal of Heat and Mass Transfer | 2014 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Thermal Effect and Joule Heating | Irreversible electroporation (IRE) is a novel method to ablate abnormal cells by applying a high voltage between the electrodes punctured in abnormal tissues. The cell membrane exposed to th… |
| IRE | Nickfarjam et al · Int J Hyperthermia | 2014 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Electrode Geometry and Placement | Purpose: Irreversible electroporation (IRE) is a new tumour ablation method used in cancer treatment procedures. In a successful IRE treatment it is crucial to impose minimum thermal damage … |
| IRE | Phillips · J Biomech Eng | 2014 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | Nonthermal irreversible electroporation (NTIRE) is an ablation modality that utilizes microsecond electric fields to produce nanoscale defects in the cell membrane. This results in selective… |
| ECT | Ritter et al · Biomed Tech (Berl) | 2013 | In Silico / Modelling | Computational Model | – | Article Fem-Driven Parameter Optimization of an Electrochemotherapy Catheter Prototype was published on September 7, 2013 in the journal Biomedical Engineering / Biomedizinische Technik (vol… |
| ECT | Campana et al · IEEE Trans. Magn. | 2013 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling | A multiobjective optimization method is used to design a treatment planning based on electrochemotherapy (ECT). A penalty function technique is coupled to NSGA algorithm in order to identify… |
| Gene ET | Corovic et al · Biomed Eng Online | 2013 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | Background: Electroporation based therapies and treatments (e.g. electrochemotherapy, gene electrotransfer for gene therapy and DNA vaccination, tissue ablation with irreversible electropora… |
| IRE | Long · Technol Cancer Res Treat | 2013 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) has been shown to be an effective method of killing cells locally. In contrast to radiofrequency ablation, the mechanism by which cells are thought to die … |
| IRE | Mahnič-Kalamiza et al · BMC Med Educ | 2012 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Background: Electrochemotherapy is a local treatment that utilizes electric pulses in order to achieve local increase in cytotoxicity of some anticancer drugs. The success of this treatment … |
| IRE | Arena et al · Appl. Phys. Lett. | 2012 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Electrode Geometry and Placement | Phase change materials (PCMs) capable of storing a large amount of heat upon transitioning from the solid-to-liquid state have been widely used in the electronics and construction industries… |
| Other EP | Garcia et al · Annu Int Conf IEEE Eng Med Biol Soc | 2012 | In Silico / Modelling | Computational Model | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Electroporation-based therapies have been gaining momentum as minimally invasive techniques to facilitate transport of exogenous agents, or directly kill tumors and other undesirable tissue … |
| Other EP | Golberg et al · Technol Cancer Res Treat | 2012 | In Silico / Modelling | Computational Model | Muscle Contraction and Anaesthesia Requirement, Electrode Geometry and Placement | The electric field threshold for muscle contraction is two orders of magnitudes lower than that for electroporation. Current electroporation treatment planning and electrode design studies f… |
| ECT | Pavliha et al · Bioelectrochemistry | 2012 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling | Electrochemotherapy uses electroporation for enhancing chemotherapy. Electrochemotherapy can be performed using standard operating procedures with predefined electrode geometries, or using p… |
| Gene ET | Zupanic et al · Phys Med Biol | 2012 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | In recent years, cancer electrochemotherapy (ECT), gene electrotransfer for gene therapy and DNA vaccination (GET) and tissue ablation with irreversible electroporation (IRE) have all entere… |
| Other EP | Čorović et al · J Membr Biol | 2012 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | In vivo electroporation is used as an effective technique for delivery of therapeutic agents such as chemotherapeutic drugs or DNA into target tissue cells for different biomedical purposes.… |
| IRE | Neal et al · IEEE Trans Biomed Eng | 2012 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | Irreversible electroporation is a new technique to kill cells in targeted tissue, such as tumors, through a nonthermal mechanism using electric pulses to irrecoverably disrupt the cell membr… |
| Other EP | Daniels et al · PLoS One | 2011 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | This study explores the hypothesis that combining the minimally invasive surgical techniques of cryosurgery and pulsed electric fields will eliminate some of the major disadvantages of these… |
| Other EP | Mahmood et al · Bioelectrochemistry | 2011 | In Silico / Modelling | Computational Model | Electrode Geometry and Placement | Current technology has limited applicability for electroporation based treatment of deep-seated tumors, and is in general, not optimized in terms of compliance with clinically relevant param… |
| Other EP | Jiang et al · Math Biosci | 2011 | In Silico / Modelling | Computational Model | Potentiation of Cytotoxic Drug Permeability, Electric Field Distribution and Modelling | Externally applied voltages can create transient, non-selective pores in a cell's membrane, a phenomenon known as electroporation. Electroporation has reduced toxicity, is easy to perform, a… |
| Other EP | Kranjc et al · IEEE Trans Med Imaging | 2011 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | Electroporation is a phenomenon caused by externally applied electric field of an adequate strength and duration to cells that results in the increase of cell membrane permeability to variou… |
| Gene ET | Pavšelj et al · International Journal of Heat and Mass Transfer | 2011 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | The use of electric pulses to increase cell membrane permeability – electroporation – has, among other applications also been used on skin for (a) enhanced transdermal molecular delivery or … |
| IRE | Adeyanju et al · Technol Cancer Res Treat | 2011 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a novel therapy used to ablate tumors with high-field electric pulses applied in short durations. It is important to reduce the generation of heat in IR… |
| Other EP | Arena et al · IEEE Trans Biomed Eng | 2011 | In Silico / Modelling | Computational Model | Transmembrane Potential Change, Electric Field Distribution and Modelling | This study introduces the use of high-frequency pulsed electric fields for tissue electroporation. Through the development of finite element models and the use of analytical techniques, elec… |
| IRE | Garcia et al · Biomed Eng Online | 2011 | In Silico / Modelling | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Thermal Effect and Joule Heating | Background: Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedu… |
| Other EP | Čorović et al · Med Biol Eng Comput | 2010 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Optimisation of Pulse Parameters | The aim of this study was to theoretically and experimentally investigate electroporation of mouse tibialis cranialis and to determine the reversible electroporation threshold values needed … |
| Gene ET | Zupanic et al · Biomed Eng Online | 2010 | In Silico / Modelling | Computational Model | Gene Electrotransfer (Plasmid DNA), Electric Field Distribution and Modelling | Background: Electroporation-based gene therapy and DNA vaccination are promising medical applications that depend on transfer of pDNA into target tissues with use of electric pulses. Gene el… |
| Other EP | Becker · Journal of Heat Transfer | 2010 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling | Skin electroporation is an approach used to enhance the transdermal transport of large molecules in which the skin is exposed to a series of electric pulses, resulting in the structural alte… |
| ECT | Kos et al · J Membr Biol | 2010 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | Treatment of cutaneous and subcutaneous tumors with electrochemotherapy has become a regular clinical method, while treatment of deep-seated tumors is still at an early stage of development.… |
| ECT | Miklavcic et al · Radiol Oncol | 2010 | In Silico / Modelling | Computational Model | Tissue Conductivity and Impedance Change, Optimisation of Pulse Parameters | Background: In order to reduce the side-effects of chemotherapy, combined chemotherapy-electroporation (electrochemotherapy) has been suggested. Electroporation, application of appropriate e… |
| IRE | Maor et al · J Biomech Eng | 2010 | In Silico / Modelling | Computational Model | Thermal Effect and Joule Heating, Reversible Membrane Permeabilisation | Tissue ablation finds an increasing use in modern medicine. Nonthermal irreversible electroporation (NTIRE) is a biophysical phenomenon and an emerging novel tissue ablation modality, in whi… |
| ECT | Corovic et al · Biomed Eng Online | 2009 | In Silico / Modelling | Human | Electric Field Distribution and Modelling, Potentiation of Cytotoxic Drug Permeability | Background: Electrochemotherapy is an effective approach in local tumour treatment employing locally applied high-voltage electric pulses in combination with chemotherapeutic drugs. In plann… |
| Gene ET | Lackovic et al · IEEE Trans. Dielect. Electr. Insul. | 2009 | In Silico / Modelling | Computational Model | Optimisation of Pulse Parameters, Electric Field Distribution and Modelling | Electrochemotherapy and electrogene therapy are new methods in molecular medicine based on electroporation-mediated introduction of foreign molecules (chemotherapeutic drugs, DNA) into targe… |
| Other EP | Pucihar et al · IEEE Trans Biomed Eng | 2009 | In Silico / Modelling | Computational Model | Transmembrane Potential Change, Electric Field Distribution and Modelling | We describe a finite-element model of a realistic irregularly shaped biological cell in an external electric field that allows the calculation of time-dependent changes of the induced transm… |
| ECT | Granot et al · Int J Heat Mass Transf | 2008 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | Reversible electroporation is the temporary permeabilization of the cell membrane through the formation of nano-scale pores that are transient defects in the membrane. These pores are caused… |
| ECT | Županič et al · Radiology and Oncology | 2008 | In Silico / Modelling | Computational Model | Electrode Geometry and Placement, Electric Field Distribution and Modelling | Optimization of electrode position and electric pulse amplitude in electrochemotherapyBackground. In addition to the chemotherapeutic drug being present within the tumor during electric puls… |
| ECT | Corovic et al · IEEE Trans. Plasma Sci. | 2008 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Electrode Geometry and Placement | Electrochemotherapy (ECT) is an effective antitumor treatment employing locally applied high-voltage electric pulses in combination with chemotherapeutic drugs. For successful ECT, the entir… |
| Other EP | Pavselj et al · IEEE Trans. Plasma Sci. | 2008 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | —The protective function of skin (its low permeability) presents a formidable obstacle in therapeutical applications such as transdermal drug delivery and gene delivery in skin. One of the p… |
| Gene ET | Pavšelj et al · Radiology and Oncology | 2008 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Optimisation of Pulse Parameters | Numerical modeling in electroporation-based biomedical applicationsBackground. Numerous experiments have to be performed before a biomedical application is put to practical use in clinical e… |
| ECT | Sel et al · IEEE Trans Biomed Eng | 2007 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Optimisation of Pulse Parameters | In electrochemotherapy (ECT) electropermeabilization, parameters (pulse amplitude, electrode setup) need to be customized in order to expose the whole tumor to electric field intensities abo… |
| Other EP | Pavselj ve Miklavcic · – | 2007 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Electric Field Distribution and Modelling | The application of electric pulses to biological cells causes the electroporation of cell membrane, increasing its permeability thus enabling the uptake of larger molecules that otherwise ca… |
| Other EP | Pavšelj et al · Ann Biomed Eng | 2007 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Electric Field Distribution and Modelling | As an alternative to viral methods that are controversial because of their safety issues, chemical and physical methods have been developed to enhance gene expression in tissues. Reversible … |
| IRE | Edd et al · Technol Cancer Res Treat | 2007 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | Irreversible Electroporation (IRE) is a new drug-free method to ablate undesirable tissue of particular use in cancer therapy. IRE achieves cell death within the targeted tissue through a se… |
| Other EP | Becker et al · J Biomech Eng | 2005 | In Silico / Modelling | Computational Model | Thermal Effect and Joule Heating, Optimisation of Pulse Parameters | Electroporation is an approach used to enhance the transport of large molecules to the cell cytosol in which a targeted tissue region is exposed to a series of electric pulses. The cell memb… |
| Other EP | Sel et al · IEEE Trans Biomed Eng | 2005 | In Silico / Modelling | Computational Model | Reversible Membrane Permeabilisation, Tissue Conductivity and Impedance Change | Permeabilization, when observed on a tissue level, is a dynamic process resulting from changes in membrane permeability when exposing biological cells to external electric field (E). In this… |
| Other EP | Nesmith et al · HardwareX | 2026 | Technical / Device Study | – | Gene Electrotransfer (Plasmid DNA) | The OpenPore pulse generator is a battery powered, portable exponential decay pulse generator for performing mammalian cell electroporation. Electroporation is a common technique for transpo… |
| Other EP | Xu et al · J. Innov. Opt. Health Sci. | 2025 | Technical / Device Study | – | Electrode Geometry and Placement | Electroacoustic Tomography (EAT) is an imaging technique that detects ultrasound waves induced by electrical pulses, offering a solution for real-time electroporation monitoring. This study … |
| Other EP | Bougandoura et al · Bioelectricity | 2024 | Technical / Device Study | – | Reversible Membrane Permeabilisation, Transmembrane Potential Change | Cancer remains a global health challenge, necessitating effective treatments with fewer side effects. Traditional methods such as chemotherapy and surgery often have complications. Pulsed el… |
| Other EP | Sheng et al · Bio-des. Manuf. | 2024 | Technical / Device Study | – | Electrode Geometry and Placement | Intracellular electrophysiological research is vital for biological and medical research. Traditional planar microelectrode arrays (MEAs) have disadvantages in recording intracellular action… |
| Other EP | Sarnago et al · IEEE Trans. Power Electron. | 2023 | Technical / Device Study | – | – | Electroporation is a promising cancer treatment based on applying short electric field pulses. In this context, highly versatile pulse generators are required to generate high-voltage low-ri… |
| IRE | Lorenzo et al · IEEE Trans Biomed Eng | 2021 | Technical / Device Study | – | Tissue Conductivity and Impedance Change, Thermal Effect and Joule Heating | Objective: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue; this results in changes in electrical properties detectable … |
| Other EP | Uluer et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2021 | Technical / Device Study | – | – | An end-fire dielectric rod antenna is proposed as a heating device for integration with an array of electroporation electrodes in order to enable efficient delivery of DNA into the cells tha… |
| Other EP | López-Alonso et al · Energies | 2021 | Technical / Device Study | – | Transmembrane Potential Change, Electric Field Distribution and Modelling | Electroporation is a phenomenon that consists of increasing the permeability of the cell membrane by means of high-intensity electric field application. Nowadays, its clinical application to… |
| ECT | Pirc et al · Electronics | 2021 | Technical / Device Study | – | Optimisation of Pulse Parameters, Muscle Contraction and Anaesthesia Requirement | Currently, in high-frequency electroporation, much progress has been made but limited to research groups with custom-made laboratory prototype electroporators. According to the review of ele… |
| IRE | Sano et al · Bioelectricity | 2020 | Technical / Device Study | – | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: Irreversible electroporation (IRE) induces cell death through nonthermal mechanisms, however, in extreme cases, the treatments can induce deleterious thermal transients. This stu… |
| ECT | Di Barba et al · JAE | 2019 | Technical / Device Study | – | Electric Field Distribution and Modelling | In the paper, a multi-objective optimization of an electrode pair for electrochemotherapy is performed. The aim is to design the electrode pair geometry in order to obtain an effective treat… |
| Other EP | Elgenedy et al · IEEE Trans. Power Electron. | 2019 | Technical / Device Study | – | – | In order to overcome the limitations of the existing classical and solid-state Marx pulse generators, this paper proposes a new modular multilevel voltage-boosting Marx pulse generator (BMPG… |
| IRE | Ritter et al · Technol Cancer Res Treat | 2018 | Technical / Device Study | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Irreversible electroporation and electrochemotherapy are 2 innovative electroporation-based minimally invasive therapies for the treatment of cancer. Combining nonthermal effects of irrevers… |
| IRE | van den Bos et al · J Vasc Interv Radiol | 2016 | Technical / Device Study | – | Irreversible Pore Formation and Cell Death, Electrode Geometry and Placement | Purpose: Irreversible electroporation (IRE) uses high-voltage electric fields to achieve cell death. Although the mechanism of IRE is mainly designated as nonthermal, development of secondar… |
| Other EP | Kranjc et al · J. Phys.: Conf. Ser. | 2013 | Technical / Device Study | – | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Electroporation is a phenomenon caused by externally applied electric field to cells that results in an increase of cell membrane permeability to various molecules. Accurate coverage of the … |
| Other EP | Guido et al · Microelectronic Engineering | 2012 | Technical / Device Study | – | Optimisation of Pulse Parameters | Electroporation is a widely used method for increasing the permeability of the cellular membrane. Impermeant exogenous substances (e.g., DNA, proteins, peptides, dyes) can thus be introduced… |
| Other EP | Troszak et al · Biomed Microdevices | 2010 | Technical / Device Study | – | – | Traditional macro and micro-electroporation devices utilize facing electrodes, which generate electric fields inversely proportional to their separation distance. Although the separation dis… |
| Other EP | Wilke et al · Sensors and Actuators A: Physical | 2005 | Technical / Device Study | – | Electrode Geometry and Placement, Potentiation of Cytotoxic Drug Permeability | This paper describes a system of silicon microneedle electrode arrays for electroporation with integrated temperature and fluidic system for drug delivery. In this research we have developed… |
| Other EP | Behrend et al · IEEE Trans. Dielect. Electr. Insul. | 2003 | Technical / Device Study | – | Apoptosis Induction, Nanosecond Pulsed Electric Field (nsPEF) | This paper describes three pulse generators: a spark gap switched coaxial cable, a spark gap switched Blumlein, and a solid state modulator, developed for applying ultrashort electrical puls… |
| ECT | Tomov et al · Bioelectrochemistry | 2000 | Technical / Device Study | – | Increased Intracellular Bleomycin Accumulation, Gene Electrotransfer (Plasmid DNA) | The electrodes used for electroporation, electrofusion, and electrotransfection, as well as in electrochemotherapy should not interact with the object and release electrolysis products. We s… |
| ECT | Brandisky et al · Bioelectrochem Bioenerg | 1999 | Technical / Device Study | – | Electrode Geometry and Placement | Electrochemotherapy is a method for cancer treatment consisting in combining intratumor injection of cytotoxic agent with the application of intensive electrical stimuli. Thus transient cell… |
| Other EP | Yang et al · Bioelectrochemistry | 2026 | Experimental Biophysics Study | Experimental System | Reversible Membrane Permeabilisation | The rigid cell wall of microalgae limits efficient intracellular protein extraction. Here, three pulsed electric field (PEF) energy distribution strategies-high-voltage few-pulse (HP), low-v… |
| Other EP | Barozzi et al · IEEE Access | 2026 | Experimental Biophysics Study | Experimental System | Tissue Conductivity and Impedance Change, Potentiation of Cytotoxic Drug Permeability | Electroporation of biological tissues induced by high-intensity, short-duration voltage pulses modify tissue permeability to molecules and ions allowing applications like drug delivery and g… |
| IRE | Guo et al · Bioelectrochemistry | 2026 | Experimental Biophysics Study | Experimental System | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | The traditional Hodgkin-Huxley (HH) model is mainly applicable to neuronal excitability under low electric fields but ails at high field intensities. In this study, an improved HH model inco… |
| Other EP | Baker et al · Sci Rep | 2024 | Experimental Biophysics Study | Human | Mitochondrial Dysfunction and Oxidative Stress, Transmembrane Potential Change | Most simulations of electric field driven bioeffects have considered spherical cellular geometries or probed symmetrical structures for simplicity. This work assesses cellular transmembrane … |
| Gene ET | Kauth et al · Ann Biomed Eng | 2023 | Experimental Biophysics Study | Human | Reversible Membrane Permeabilisation, Electrode Geometry and Placement | When a cell or tissue is exposed to a pulsed electric field (100-1000 V/cm), the cellular membrane permeabilizes for biomolecules that cannot pass an intact cellular membrane. During this el… |
| Other EP | Briz et al · Bioelectrochemistry | 2023 | Experimental Biophysics Study | Human | Tissue Conductivity and Impedance Change | Electroporation is a phenomenon produced in the cell membrane when it is exposed to high pulsed electric fields that increases its permeability. Among other application fields, this phenomen… |
| IRE | Cvetkoska et al · Sci Rep | 2022 | Experimental Biophysics Study | Human | Muscle Contraction and Anaesthesia Requirement, Irreversible Pore Formation and Cell Death | To minimize neuromuscular electrical stimulation during electroporation-based treatments, the replacement of long monophasic pulses with bursts of biphasic high-frequency pulses in the range… |
| ECT | Tamra et al · IEEE Trans Biomed Eng | 2022 | Experimental Biophysics Study | Experimental System | Reversible Membrane Permeabilisation, Increased Intracellular Bleomycin Accumulation | This paper presents a 40 GHz microwave biosensor used to monitor and characterize single cells (THP-1) subjected to electrochemotherapy and obtain an electronic signature of the treatment ef… |
| Other EP | Ganesan et al · Electronics | 2022 | Experimental Biophysics Study | Experimental System | Optimisation of Pulse Parameters | Electroporation is a next generation bioelectronics device. The emerging application of electroporation requires high voltage pulses having a pulse-width in the nanosecond range. The essenti… |
| Other EP | Lv et al · IEEE Access | 2020 | Experimental Biophysics Study | Experimental System | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | When delivered across a cell, certain pulsed electric fields can cause an increase in the cell membrane permeability through a biophysical process known as electroporation. The current signa… |
| Other EP | Ye et al · Micromachines (Basel) | 2020 | Experimental Biophysics Study | Experimental System | Tissue Conductivity and Impedance Change | The electroporation system can serve as a tool for the intracellular delivery of foreign cargos. However, this technique is presently limited by the inaccurate electric field applied to the … |
| IRE | López-Alonso · Sensors (Basel) | 2020 | Experimental Biophysics Study | Experimental System | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | Classical application of electroporation is carried out by using fixed protocols that do not clearly assure the complete ablation of the desired tissue. Nowadays, new methods that pursue the… |
| Other EP | Chiapperino et al · Bioelectromagnetics | 2019 | Experimental Biophysics Study | Experimental System | Transmembrane Potential Change | In this work, the electroporation phenomenon induced by pulsed electric field on different nucleated biological cells is studied. A nonlinear, non-local, dispersive, and space-time multiphys… |
| Other EP | Hristov et al · Biochim Biophys Acta Biomembr | 2018 | Experimental Biophysics Study | Human | Nanosecond Pulsed Electric Field (nsPEF), Reversible Membrane Permeabilisation | We compared membrane permeabilization by nanosecond pulsed electric field (nsPEF) in HEK293 cells with and without assembled CaV1.3 L-type voltage-gated calcium channel (VGCC). Individual ce… |
| Other EP | Zhao et al · Sensors (Basel) | 2018 | Experimental Biophysics Study | Human | Tissue Conductivity and Impedance Change, Potentiation of Cytotoxic Drug Permeability | Skin penetration is related to efficiencies of drug delivery or ISF extraction. Normally, the macro-electrode is employed in skin permeability promotion and evaluation, which has the disadva… |
| Other EP | Davies et al · Biomed. Phys. Eng. Express | 2018 | Experimental Biophysics Study | Experimental System | Tissue Conductivity and Impedance Change | Electroporation is the creation of pores in a cell by applying an external electrical field and creating a voltage in the range of 200 mV–1 V across the cell’s membrane. This process is used… |
| ECT | Calin et al · Biomed Opt Express | 2017 | Experimental Biophysics Study | Experimental System | Reversible Membrane Permeabilisation | Changes in optical and shape-related characteristics of B16F10 cells after electroporation were investigated using digital holographic microscopy (DHM). Bipolar rectangular pulses specific f… |
| IRE | Yao · PLoS One | 2017 | Experimental Biophysics Study | – | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) produced by a pulsed electric field can ablate tissue. In this study, we achieved an enhancement in ablation area by using a combination of short high-volt… |
| IRE | Miklovic et al · Ann Biomed Eng | 2017 | Experimental Biophysics Study | – | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Several focal therapies are being investigated clinically to treat tumors in which surgery is contraindicated. Many of these ablation techniques, such as radiofrequency ablation and microwav… |
| Other EP | Breton et al · IEEE Trans. Magn. | 2015 | Experimental Biophysics Study | Experimental System | Reversible Membrane Permeabilisation, Necrosis and Necroptosis | We propose a non-linear steady-state model of irreversible electropermeabilization in a biological tissue. The non-linear problem is solved using a modified fixed point iteration. The unknow… |
| IRE | KURATA et al · JBSE | 2013 | Experimental Biophysics Study | – | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is attracting much attention as a less-invasive therapy to ablate abnormal tissues. With a pair of electrodes inserted into the tissue, the IRE perforates … |
| ECT | Dotsinsky et al · Biotechnology & Biotechnological Equipment | 2012 | Experimental Biophysics Study | Human | Optimisation of Pulse Parameters, Increased Intracellular Bleomycin Accumulation | Electrochemotherapy is based on electroporation, which creates aqueous pathways in the cell membrane as a result of applied short intensive electric field usually generated by high voltage e… |
| Other EP | Golzio et al · Phys Chem Chem Phys | 2010 | Experimental Biophysics Study | Experimental System | Reversible Membrane Permeabilisation, Electrode Geometry and Placement | An experimental validation of electropermeabilization inducing field distribution in tissue predicted by simulation for needle electrodes is described giving a direct visualization of the pe… |
| Other EP | Mottet et al · J. Micromech. Microeng. | 2010 | Experimental Biophysics Study | Experimental System | – | International audience |
| IRE | Hjouj et al · J Membr Biol | 2010 | Experimental Biophysics Study | – | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | We introduce and characterize the use of MRI for studying nonthermal irreversible electroporation (NTIRE) in a vegetative tissue model. NTIRE is a new minimally invasive surgical technique f… |
| Other EP | Vernier et al · PLoS One | 2009 | Experimental Biophysics Study | Human | Reversible Membrane Permeabilisation, Gene Electrotransfer (Plasmid DNA) | Reversible electropermeabilization (electroporation) is widely used to facilitate the introduction of genetic material and pharmaceutical agents into living cells. Although considerable know… |
| IRE | Davalos et al · International Journal of Heat and Mass Transfer | 2008 | Experimental Biophysics Study | Experimental System | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Certain electrical fields, when applied across a cell membrane, can have the sole effect of membrane permeabilization, which is referred to as electroporation. When the permeabilization is ir… |
| IRE | Esser et al · Technol Cancer Res Treat | 2007 | Experimental Biophysics Study | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Local and drug-free tissue treatment by irreversible electroporation (IRE) involves the creation of aqueous pores in a cell's plasma membrane (PM) and leads to non-thermal cell death by necr… |
| Other EP | Pliquett et al · Bioelectrochemistry | 2004 | Experimental Biophysics Study | Human | Thermal Effect and Joule Heating | The electroporative effect on the stratum corneum (SC) is highly localized. However, the fractional area for the transport of small ions and larger ionic species differs considerably during … |
| ECT | Cemazar et al · Br J Cancer | 2001 | Experimental Biophysics Study | Cell Culture | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Recent studies have indicated that the antitumour effectiveness of electrochemotherapy, a combination of chemotherapeutic drugs with application of high voltage electric pulses applied to th… |
| Other EP | Pliquett et al · Bioelectrochemistry and Bioenergetics | 1996 | Experimental Biophysics Study | Experimental System | Thermal Effect and Joule Heating, Transmembrane Potential Change | Eiectroporation is well known to depend non-linearly on the magnitude and duration of the change AU(t) in transmembrane voltage. In the case of cell suspension experiments, an electric field… |
| Other EP | Rols et al · Journal of Electroanalytical Chemistry and Interfacial Electrochemistry | 1990 | Experimental Biophysics Study | Experimental System | Reversible Membrane Permeabilisation | Cells can be permeabilized transiently when pulsed b y high intensity short duration electric fields. T h e molecular m e c h a n i s m s underlaying this electropermeabilization are still u… |
| Gene ET | Ishii-Teshima et al · – | 2026 | Preprint | Computational Model | Tissue Conductivity and Impedance Change, Gene Electrotransfer (Plasmid DNA) | A microelectrode-based electroporator serves as a customizable microscale electroporation platform. For practical applications, stable operation of the system and precise estimation of the e… |
| ECT | Peña et al · – | 2025 | Preprint | Animal (In Vivo) | – | This publication has no abstract. |
| Other EP | Iimura et al · – | 2025 | Preprint | Cell Culture | Optimisation of Pulse Parameters | Electroporation has traditionally been widely performed using metal electrodes, but reports indicate these electrodes exhibit cytotoxicity. Polypyrrole, a conductive and biocompatible polyme… |
| Other EP | Yoshida et al · – | 2024 | Preprint | – | Gene Electrotransfer (Plasmid DNA) | Non-viral mediated plasmid DNA transfection by electroporation (EP) is an established method for gene transfection. In this study, the usefulness of direct EP at an intradermal (i.d.) site (… |
| Other EP | Lopez-Alonso et al · – | 2024 | Preprint | Cell Culture | – | This publication has no abstract. |
| Other EP | García Sánchez · – | 2023 | Thesis | Cell Culture | Tissue Conductivity and Impedance Change, Reversible Membrane Permeabilisation | The present PhD dissertation is focused on the design and implementation of a microelectrode system capable of performing electroporation and electrical impedance measurements to adherent ce… |
| ECT | Blažič et al · Proceedings of the 4th URSI Atlantic RadioScience Conference – AT-RASC 2024 | 2024 | Conference Abstract | Cell Culture | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Electroporation is a phenomenon in which exposure of a cell to pulsed electric field causes the formation of pores in the cell membrane.During the period of increased membrane permeability, … |
| Other EP | Dou et al · 2024 MicroTAS Book of Abstracts | 2024 | Conference Abstract | Cell Culture | Electric Field Distribution and Modelling | Reference No: 0625 AN INTERGATED PLATFORM ENABLING ISOLATING AND ELECTROPORATION TRANSFECTING OF CIRCULATING TUMOR CELLS HIGH EFFICIENTLY Songtao Dou1, Qingmei Xu2, Shitao Shen2, Qi Wang3, Y… |
| Gene ET | Ursic Valentinuzzi et al · Poster Presentations | 2022 | Conference Abstract | – | Interleukin-12 Mediated Immune Stimulation, Potentiation of Cytotoxic Drug Permeability | Background Electrochemotherapy (ECT) exhibits high therapeutic effectiveness in the clinic, achieving up to 80% local tumor control but without a systemic (abscopal) effect. It was proposed … |
| Other EP | Folprecht et al · Proceedings II of the 28st Conference STUDENT EEICT 2022: Selected papers. | 2022 | Conference Abstract | – | Muscle Contraction and Anaesthesia Requirement | This paper discusses an application of different waveforms during a cell electroporation process. Latest scientific papers emphasize advantages of asymmetrical waveform applied to tissue. Hi… |
| ECT | Malysko et al · 2021 13th International Conference on Measurement | 2021 | Conference Abstract | Computational Model | Reversible Membrane Permeabilisation, Electric Field Distribution and Modelling | Electroporation is a highly effective method in various fields of application, including cancer treatment, where when combined with drugs (called electrochemotherapy), it improves treatment … |
| Other EP | Brimmo et al · World Congress on Electrical Engineering and Computer Systems and Science | 2021 | Conference Abstract | – | Electrode Geometry and Placement | Here, a simple pin-plate electrode setup has been constructed to reliably electroporate biological cells within droplets. The process constitutes temporary permeabilization of the plasma mem… |
| ECT | Aleynik et al · 2014 12th International Conference on Actual Problems of Electronics Instrument Engineering (APEIE) | 2014 | Conference Abstract | – | – | A layout of the device for the treatment of malignant tumors with electroporation is developed. Investigation of the device characteristics is conducted. Animal model studies have confirmed … |
| ECT | Miklavčič · WIT Transactions on Biomedicine and Health | 2003 | Conference Abstract | Cell Culture | Optimisation of Pulse Parameters, Muscle Contraction and Anaesthesia Requirement | Electrochemotherapy is a technique where electric pulses in combination with chemotherapeutic agents are applied to tumor cells. In general, patients find electrochemotherapy tolerable, in s… |
| ECT | Music · WIT Transactions on Biomedicine and Health | 2003 | Conference Abstract | Cell Culture | – | Electrochemotherapy is a local treatment of tumors in which high voltage electric pulses are used for permeabilization of cell membrane (electroporation) thus enabling increased entry of che… |
| Other EP | Huang et al · 2002 Solid-State, Actuators, and Microsystems Workshop Technical Digest | 2002 | Conference Abstract | – | Gene Electrotransfer (Plasmid DNA) | We describe a chip that is capable of performing gene transfer in individual biological cells through single cell microelectroporation. Microfluidic channels are used to handle individual ce… |
| IRE | Rouientan et al · J Vasc Interv Radiol | 2026 | Editorial / Letter | – | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | This publication has no abstract. |
| Other EP | Kulbacka et al · Expert Opin Drug Deliv | 2025 | Editorial / Letter | – | Potentiation of Cytotoxic Drug Permeability | 1. Drug resistance or even multidrug resistance (MDR) in cancer is still one of the greatest challenges in oncological therapy today. Many cancers develop mechanisms to evade conventional tr… |
| IRE | Tewari et al · Cardiovasc Intervent Radiol | 2025 | Editorial / Letter | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | This publication has no abstract. |
| ECT | Rembiałkowska et al · Pharmaceuticals (Basel) | 2024 | Editorial / Letter | – | – | This Special Issue is dedicated to the memory of Professor Jolanta Saczko (1964-2023), a remarkable leader whose guidance and dedication were instrumental in advancing electroporation-based … |
| Other EP | De Robertis et al · Vaccines (Basel) | 2023 | Editorial / Letter | – | – | Immunotherapy can now be regarded as an attractive approach for cancer and infectious disease treatments [...]. |
| Other EP | Heller et al · Technol Cancer Res Treat | 2019 | Editorial / Letter | Human | Optimisation of Pulse Parameters | Electroporation Based Therapies - Editorial Special Collection on ElectroporationBased Therapies: A Selection of Papers From the Second World Congress on Electroporation Technology in Cancer… |
| IRE | Miklavcic et al · Biomed Eng Online | 2015 | Editorial / Letter | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | When a cell is exposed to a sufficiently intense electric field (for a sufficient duration), local defects in the cell membrane appear and become permeable to molecules that otherwise cannot… |
| IRE | Heger et al · Hepatobiliary Pancreat Dis Int | 2015 | Editorial / Letter | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is a CE- and FDAapproved treatment modality for pancreatic and liver tumors that is based on the site-confined destruction of tumor tissue by multiple shor… |
| IRE | Davalos et al · Prostate | 2015 | Editorial / Letter | Human | Irreversible Pore Formation and Cell Death, Thermal Effect and Joule Heating | Irreversible electroporation (IRE) describes a cellular response to electric field exposure, resulting in the formation of nanoscale defects that can lead to cell death. While this behavior … |
| Other EP | Heller · Technol Cancer Res Treat | 2002 | Editorial / Letter | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Gene Electrotransfer (Plasmid DNA) | This special issue of Technology in Cancer Research and Treatment focuses on the versatility of electroporation. Contributed papers report on the basic mechanisms as well as the use of this … |
| Other EP | Hui · Biophys J | 1998 | Editorial / Letter | Human | – | This publication has no abstract. |
| ECT | Vizintin et al · Radiol Oncol | 2023 | Correction / Erratum | – | Increased Intracellular Cisplatin Accumulation | In Figure 3A, three horizontal bars representing the standard deviation were incorrectly drawn.The corrected figure is shown below. |
| Calcium EP | Hansen et al · PLoS One | 2015 | Correction / Erratum | Cell Culture | Calcium Electroporation and ATP Depletion, Electric Field Distribution and Modelling | This publication has no abstract. |
| Other EP | Tao et al · Research (Wash D C) | 2026 | Not reported | – | – | Nonviral intracellular delivery based on pulsed-electric-field-induced electroporation is one of the most effective and widely used platforms in basic biological and biomedical research. How… |
| IRE | Xiang · BMC Surg | 2025 | Not reported | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: Irreversible electroporation (IRE) is a non-thermal ablation technique using high-voltage, low-energy pulses to induce cell membrane perforation and cell death. As an emerging th… |
| Other EP | Jiang et al · Precis Radiat Oncol | 2024 | Not reported | – | Nanosecond Pulsed Electric Field (nsPEF) | Background: Nanosecond pulsed electric fields (nsPEF)-based electroporation is a new therapy modality potentially synergized with radiation therapy to improve treatment outcomes. To verify i… |
| Other EP | Gurunian et al · Bioelectrochemistry | 2023 | Not reported | – | – | We used voltage-clamp electroporation to obtain single-channel recordings of lipid pores and analyzed the idealized dwell-time sequences using Maximum-Likelihood Fitting. We observed traces … |
| Undetermined | Plesnik et al · Anal Bioanal Chem | 2023 | Not reported | – | Increased Intracellular Bleomycin Accumulation | The effectiveness of highly polar agents in cancer treatment is well recognized, but their physicochemical properties make their analytical determination a demanding task. Their analysis req… |
| Other EP | Gurunian et al · Bioelectrochemistry | 2022 | Not reported | – | – | Current-Clamp electroporation refers to the application of a constant current across a membrane which results in voltage fluctuations due to the creation of electropores. This method allows … |
| Undetermined | Cindrič et al · ZdravVestn | 2021 | Not reported | – | – | Koncept ireverzibilne elektroporacije kot samostojne ablacijske metode je bil prvič predstavljen pred petnajstimi leti. Ireverzibilna elektroporacija predstavlja alternativo uveljavljenim te… |
| Other EP | Zhou et al · Biomed Eng Online | 2019 | Not reported | – | Reversible Membrane Permeabilisation | Background: After the discovery of membrane-reversible electroporation decades ago, the procedure has been used extensively in biology, biotechnology and medicine. The research on the basic … |
| Other EP | Rauso · CDOAJ | 2018 | Not reported | – | – | Background: Assessment of the effectiveness and tolerability, with regard to facial photoageing, of a solution containing a blend of amino acids and low molecular weight hyaluronic acid (Sun… |
| Other EP | de Menorval et al · Sci Rep | 2016 | Not reported | Cell Culture | – | Human adipose mesenchymal stem cells (haMSCs) are multipotent adult stem cells of great interest in regenerative medicine or oncology. They present spontaneous calcium oscillations related t… |
| Other EP | Čorović et al · Biomed Eng Online | 2016 | Not reported | – | – | Background: Electroporation-based applications require multidisciplinary expertise and collaboration of experts with different professional backgrounds in engineering and science. Beginning … |
| Other EP | Guenther et al · Biochem Biophys Res Commun | 2015 | Not reported | Human | – | Electroporation, the permeabilization of the cell membrane by brief, high electric fields, has become an important technology in medicine for diverse application ranging from gene transfecti… |
| Other EP | de Baere et al · Diagn Interv Imaging | 2014 | Not reported | Human | Irreversible Pore Formation and Cell Death | Since the introduction of radiofrequency ablation (RFA) for the treatment of liver tumors at the end of the 1990s, indications for local ablation techniques have been extended to other organ… |
| Other EP | Mahnič-Kalamiza et al · Biochim Biophys Acta | 2014 | Not reported | – | – | In many electroporation applications mass transport in biological tissue is of primary concern. This paper presents a theoretical advancement in the field and gives some examples of model us… |
| Other EP | Miklavčič · J Membr Biol | 2012 | Not reported | Human | – | Exposure of biological cells to a sufficiently strong external electric field results in increased permeability of cell membranes, referred to as "electroporation." Since all types of cells … |
| Other EP | Anon · Molecular Therapy | 2012 | Not reported | – | Gene Electrotransfer (Plasmid DNA) | This publication has no abstract. |
| Other EP | Mpendo et al · Retrovirology | 2012 | Not reported | – | Gene Electrotransfer (Plasmid DNA) | DNA vaccines are weakly immunogenic in humans and one way of increasing their immunogenicity is by administering the vaccines using electroporation (EP). This technique increases the uptake … |
| Other EP | Fernand et al · Biotechnol Bioeng | 2012 | Not reported | – | – | The mathematical solution to the electric field equation in cylindrical coordinates, has suggested to us a new experimental methodology and device for reducing experimental effort in designi… |
| Other EP | Lin et al · Biophysical Journal | 2011 | Not reported | Computational Model | Electric Field Distribution and Modelling | This publication has no abstract. |
| ECT | Shankayi et al · J Membrane Biol | 2011 | Not reported | – | – | J Membrane Biol (2011) 244:129 DOI 10.1007/s00232-011-9410-6 ERRATUM Erratum to: Tumor Growth Inhibited by Low-Voltage Amplitude and 5-kHz Frequency Electrochemotherapy Z. Shankayi • S. M. P… |
| Other EP | Kotulska et al · J Membr Biol | 2010 | Not reported | – | – | Single metastable nanopores, appearing before the actual electroporation under constant-current conditions, are used to characterize the onset of electroporation. Unlike the long-lived elect… |
| IRE | Golberg et al · Technol Cancer Res Treat | 2010 | Not reported | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Electroporation is a physical phenomenon in which pulsed electric fields applied across a cell produce transient (reversible) or permanent (irreversible) permeabilization of the cell membran… |
| ECT | Sersa et al · Curr Oncol | 2009 | Not reported | – | – | Several novel tumour-targeting and drug-delivery approaches in cancer treatment are currently undergoing intensive investigation, among them physical approaches such as tissue electroporatio… |
| Other EP | Mossop et al · Ann Biomed Eng | 2007 | Not reported | – | – | One of the key issues in electric field-mediated molecular delivery into cells is how the intracellular field is altered by electroporation. Therefore, we simulated the electric field in bot… |
| ECT | Dev ve Hofmann · Rehabilitation Oncology | 1995 | Not reported | – | – | This publication has no abstract. |
No publication matches these filters.
Limitations
The counts on this page are bounded by the scope of the source PDF archive and are not a systematic review of the area's literature.
A literature maturity label reflects the number of publications, not their methodological quality: it describes how much literature exists in the area and of what kind, not how strongly the treatment is supported. It does not indicate clinical use, guideline endorsement, reimbursement coverage or regulatory status, and it is not a formal GRADE assessment. The definitions and thresholds of the four tiers are on the Literature Map.
The “clinical publications” figure on this page (59) uses the portal's single definition: primary clinical studies, case series and case reports. Systematic reviews and guidelines are not included. The count feeding the badge threshold is narrower and does not count case reports; in this area 3 publications enter that threshold count across every method together (ECT 0 · IRE 2 · PFA 0 · Calcium EP 0 · Gene ET 0 · Other EP 1 · Undetermined 0), whereas the badge at the top of the page rests on the ECT count alone. The two counts are not the same and cannot stand in for one another; the full threshold table is on the Literature Map.
34 of the 968 records in this area enter the threshold count. The remaining 934 are marked in the validation ledger as conflicting, insufficient or out of scoring; they appear in the table below but affect no threshold and no badge. That share (4%) is not equal across areas: it is 13% portal-wide and ranges from 0% to 42% by area. Two areas' badges therefore cannot be compared directly; a lower badge can reflect narrower verification coverage as much as a narrower literature.
Literature maturity on this page is given separately for each clinical method. The methods present in this area are: Electrochemotherapy (ECT), Irreversible electroporation (IRE), Pulsed-field ablation (PFA), Calcium electroporation, Gene electrotransfer, Other electroporation applications, Records with no determined method. Methods may share the same biophysical basis but they are distinct treatments; evidence gathered for one method cannot be generalised to another.