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Group: Urogynaecological Tumours

IRE: Exploratory / low-volume literature2 publications

Endometrial Cancer

Electroporation-based approaches in endometrial cancer are represented by only a handful of records in the corpus; the area is exploratory.

2publication records
1clinical publication records
1preclinical publication record
0reviews
2013–2017publication span

Clinical publications: randomized, prospective and retrospective studies, case series and case reports. Preclinical publications: animal, in vitro, modelling and experimental biophysics studies.

Clinical and Technical Data Reported in the Publications

The sum of the fields reported in the full text of the 2 publications in this area. The numbers are summed, not interpreted.

Sum of the patient counts reported across publications1 (reported in 1 publications)
Total lesions reported1 (in 1 publications)
Devices used (1 publications naming a device)NanoKnife (1)
Approach (2 publications report it)percutaneous (1) · open surgical (1)
Image guidance (2 publications report it)computed tomography (1) · ultrasound (1) · direct vision (1)
Response criteria (1 publications report it)clinical examination (1)
Publications reporting retreatment1 of 2 publications (0 do not report it)
Field strength1500 V/cm
Applied voltage3000 V
Number of pulses70–90 (2 records, median 90)
Pulse duration70 µs

The totals are not a count of unique patients: the same cohort may have been reported in more than one publication.

Literature Status by Method

Publication count, clinical and preclinical split, literature volume and publication span for each clinical method. The badge at the top of the page summarises the IRE record only; the full split by method is here.

Irreversible electroporation (IRE)

2publication records
1clinical publication records
1preclinical publication record

Exploratory / low-volume literaturethreshold 0/2 records

No record for this method feeds the volume label.

2013–2017

Mechanisms Mentioned in Abstracts

The figure is the number of abstracts mentioning the mechanism. A mention does not mean it was demonstrated in that study.

Irreversible Pore Formation and Cell Death 2 Reversible Membrane Permeabilisation 2 Transmembrane Potential Change 1 Apoptosis Induction 1

Study Type Distribution

The percentage gives the share of the whole area.

Study typePublicationsShare within this area
Case Report1
50%
Animal Study1
50%

Publication Table

2 publication records sorted by study design. Click a title to open the citation, mechanism and full abstract drawer.

Classifications are generated automatically and can be wrong for individual records. Methodology

RegimePublicationYearStudy typeModelMechanismPatients / lesionsDeviceAgent and routeReported outcomeAbstract
IRE
Niessen et al · J Med Case Rep
2013Case ReportHumanIrreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation1 / 1––tumour volume change 791 cm³ (1 patients)Introduction: Irreversible electroporation (IRE) is a new minimally invasive tumor ablation technique which induces irreversible disruption of cell membrane integrity by changing the transme…
IRE
Chai et al · Biomed Microdevices
2017Animal StudyAnimal (In Vivo)Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation–NanoKnife––The aim of this study was to evaluate the effects of irreversible electroporation (IRE) on the uterine cervix in a rabbit model. IRE ablation was performed in the cervices of 48 New Zealand …

Limitations

Publication volume is not clinical efficacy or evidence quality. It describes how much literature exists in the area and of what kind; it does not indicate how strongly the treatment is supported, guideline endorsement or regulatory status.

Patient totals are not a count of unique patients. The same cohort may have been reported in more than one publication; the totals are not a meta-analysis.

How the corpus was assembled, the tier thresholds, the definition of a clinical publication and why methods are counted separately: Literature Map.