Group: Musculoskeletal & CNS
Bone & Soft Tissue Sarcomas
In bone metastases and soft tissue sarcomas, electrochemotherapy has been studied for pain palliation, local control and preoperative volume reduction. The high impedance of bone and the need for imaging guidance in electrode placement are technical themes specific to this area.
64publication records61 unique studies once versions are merged
25clinical publication records
27preclinical publication records
11reviews
1997–2026publication span
Clinical publications: randomized, prospective and retrospective studies, case series and case reports. Preclinical publications: animal, in vitro, modelling and experimental biophysics studies.
Clinical and Technical Data Reported in the Publications
The sum of the fields reported in the full text of the 64 publications in this area. The numbers are summed, not interpreted.
Sum of the patient counts reported across publications608 (reported in 28 publications)
Total lesions reported707 (in 18 publications)
Devices used (41 publications naming a device)Cliniporator VITAE (12) · NanoKnife (6) · Cliniporator (5) · Jouan GHT 1287 (4) · Square Electroporator CUY-21 (2) · GT-01 (2)
Agent delivered and route (44 publications reporting an agent)bleomycin · intravenous (24) · bleomycin · intratumoural (5) · cisplatin · intratumoural (3) · cisplatin · intravenous (2) · other · intravenous (2) · plasmid DNA · intratumoural (2)
Approach (50 publications report it)percutaneous (37) · open surgical (8) · transcutaneous surface (4) · intraoperative (1)
Image guidance (41 publications report it)computed tomography (23) · direct vision (16) · fluoroscopy (7) · ultrasound (6) · magnetic resonance imaging (1)
Response criteria (25 publications report it)other (6) · RECIST 1.1 (6) · RECIST (5) · clinical examination (5) · histological (1)
Combination therapy (37 publications report it)systemic chemotherapy (21) · other combination (11) · radiotherapy (6) · surgery (3) · other immunotherapy (3)
Publications reporting retreatment18 of 50 publications (14 do not report it)
Field strength50–1750 V/cm (35 records, median 1000)
Applied voltage150–3000 V (10 records, median 2000)
Number of pulses6–120 (41 records, median 8)
Pulse duration70–100000 µs (40 records, median 100)
The totals are not a count of unique patients: the same cohort may have been reported in more than one publication.
Literature Status by Method
Publication count, clinical and preclinical split, literature volume and publication span for each clinical method. The badge at the top of the page summarises the ECT record only; the full split by method is here.
Electrochemotherapy (ECT)
39publication records
18clinical publication records
17preclinical publication records
Limited clinical publication volumethreshold 7/39 records
Clinical and preclinical split of that figure: 5 clinical, 1 preclinical.
1997–2026
Irreversible electroporation (IRE)
13publication records
6clinical publication records
4preclinical publication records
Exploratory / low-volume literaturethreshold 3/13 records
Clinical and preclinical split of that figure: 1 clinical, 0 preclinical.
2011–2026
Calcium electroporation
1publication records
0clinical publication records
0preclinical publication records
Exploratory / low-volume literaturethreshold 0/1 records
No record for this method feeds the volume label.
2019–2019
Gene electrotransfer
3publication records
0clinical publication records
3preclinical publication records
Exploratory / low-volume literaturethreshold 0/3 records
No record for this method feeds the volume label.
2006–2013
Other electroporation applications
8publication records
1clinical publication records
3preclinical publication records
This set does not name a single clinical method; no literature volume is assigned.
2000–2024
Mechanisms Mentioned in Abstracts
The figure is the number of abstracts mentioning the mechanism. A mention does not mean it was demonstrated in that study.
Reversible Membrane Permeabilisation 19
Increased Intracellular Bleomycin Accumulation 18
Irreversible Pore Formation and Cell Death 15
Increased Intracellular Cisplatin Accumulation 9
Electric Field Distribution and Modelling 9
Potentiation of Cytotoxic Drug Permeability 7
Electrode Geometry and Placement 7
Necrosis and Necroptosis 5
Haemostasis and Bleeding Control 4
Gene Electrotransfer (Plasmid DNA) 3
Apoptosis Induction 3
Systemic / Abscopal Immune Response 2
Study Type Distribution
The percentage gives the share of the whole area.
| Study type | Publications | Share within this area |
|---|---|---|
| Prospective Clinical Study | 2 | 3% |
| Clinical Study | 8 | 12% |
| Retrospective Clinical Study | 1 | 2% |
| Case Series | 1 | 2% |
| Case Report | 13 | 20% |
| Review | 11 | 17% |
| Animal Study | 20 | 31% |
| In Vitro Study | 2 | 3% |
| In Silico / Modelling | 4 | 6% |
| Experimental Biophysics Study | 1 | 2% |
| Correction / Erratum | 1 | 2% |
Publication Table
64 publication records sorted by study design. Click a title to open the citation, mechanism and full abstract drawer.
Classifications are generated automatically and can be wrong for individual records. Methodology
| Regime | Publication | Year | Study type | Model | Mechanism | Patients / lesions | Device | Agent and route | Reported outcome | Abstract |
|---|---|---|---|---|---|---|---|---|---|---|
| ECT | Ottlakan et al · Bioelectrochemistry | 2022 | Prospective Clinical Study | Human | Increased Intracellular Bleomycin Accumulation, Electrode Geometry and Placement | 7 / 7 | Cliniporator VITAE | bleomycin · intravenous | partial response 5 count (7 patients) | The aim of the current prospective pilot study exclusively for deep-seated soft tissue sarcomas (STS) was to evaluate efficacy and safety of bleomycin-based ECT using VEG (variable electrode… |
| IRE | Martin et al · BMC Cancer | 2014 | Prospective Clinical Study | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | 107 / 117 | NanoKnife | – | local recurrence 12.7 months | Background: Irreversible electroporation (IRE) has recently been added as an additional therapeutic ablative option in patients with locally advanced cancers (LAC) involving vital structures… |
| ECT | Cevolani et al · J Surg Oncol | 2023 | Clinical Study | Human | Necrosis and Necroptosis | – | Cliniporator VITAE | – | – | Background: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment based on a high-voltage electric pulse combined with an anticanc… |
| ECT | Campanacci et al · Curr Oncol | 2022 | Clinical Study | Human | – | 38 | Cliniporator VITAE | bleomycin · intravenous | objective response 25% (37 patients) | Bone metastases induce pain, risk of fracture, and neural compression, and reduced mobility and quality of life. Electrochemotherapy (ECT) is a minimally invasive local treatment based on a … |
| ECT | Campanacci et al · Eur J Surg Oncol | 2021 | Clinical Study | Human | – | 102 | Cliniporator VITAE | bleomycin · intravenous | objective response 40.4% (89 patients) | Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in … |
| ECT | Simioni et al · Sci Rep | 2020 | Clinical Study | Human | Increased Intracellular Bleomycin Accumulation, Electrode Geometry and Placement | 30 | Cliniporator VITAE | bleomycin · intravenous | complete response 63% (30 patients) | Standard electrochemotherapy (ECT) is effective in many tumour types but is confined to the treatment of small superficial lesions. Variable electrode-geometry ECT (VEG-ECT) may overcome the… |
| ECT | Bianchi et al · World J Surg | 2016 | Clinical Study | Human | – | 29 | Cliniporator VITAE | bleomycin · intravenous | objective response 1 count (20 patients) | Introduction: Bone metastatic disease is a major cause of pain and decreased quality of life in patients with cancer. In addition to systemic therapy and pain control with narcotic analgesic… |
| ECT | Guida et al · Annals of Oncology | 2016 | Clinical Study | Human | – | 19 / 54 | – | bleomycin · intravenous | objective response 63% (19 patients) | Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, © The Author 2016. Published by Oxford … |
| ECT | Guida et al · European Journal of Surgical Oncology (EJSO) | 2016 | Clinical Study | Human | Increased Intracellular Bleomycin Accumulation, Antivascular Effect and Vessel Disruption | 19 / 54 | – | bleomycin · intravenous | objective response 63% (19 patients) | Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, which exerts prominent anti-tumour acti… |
| ECT | Campana et al · World J Surg | 2013 | Clinical Study | Human | Electrode Geometry and Placement, Increased Intracellular Bleomycin Accumulation | 34 / 71 | – | bleomycin · intravenous | objective response 92.2% (71 lesions) | Aims: Our aim was to evaluate the activity, toxicity, and feasibility of electrochemotherapy (ECT) in patients with soft-tissue sarcomas (STS). Methods: A two-stage phase II trial was conduc… |
| ECT | Deschamps et al · Eur J Cancer | 2023 | Retrospective Clinical Study | Human | Increased Intracellular Bleomycin Accumulation | 40 | Cliniporator VITAE | bleomycin · intravenous | tumour volume change 46% (35 patients) | Objective: To report efficacy and safety of percutaneous electrochemotherapy (ECT) in patients with radiotherapy-resistant metastatic epidural spinal cord compression (MESCC). Material/ meth… |
| ECT | Tedesco et al · J Clin Med | 2024 | Case Series | Human | Increased Intracellular Bleomycin Accumulation | 2 | Cliniporator VITAE | bleomycin · intravenous | – | (1) Background: this case series and literature review aims to evaluate the efficacy and safety of electrochemotherapy in the management of aggressive spinal hemangiomas, presenting two dist… |
| ECT | Siew et al · Cardiovasc Intervent Radiol | 2026 | Case Report | Human | Reversible Membrane Permeabilisation, Electrode Geometry and Placement | 1 / 1 | bipolar bone electroporation needle | bleomycin · intravenous | tumour volume change 100% (1 patients) | Vertebral haemangiomas are benign lesions that developed from vascular proliferation within bone marrow spaces [1]. As these malformations do not grow by mitotic activity and lack any malign… |
| IRE | Pusceddu · Diagn Interv Radiol | 2026 | Case Report | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | 1 / 1 | NanoKnife | – | complete response 1 count (1 patients) | Bone metastases are common in advanced solid tumors and often require local control strategies in addition to systemic therapy. Although thermal ablation is an established method for selecte… |
| ECT | Angelini et al · Diagnostics (Basel) | 2024 | Case Report | Human | Necrosis and Necroptosis | – | Cliniporator VITAE | – | – | Metastases are complications of primary tumors due to prolonged cancer survival and have become an important issue for oncological patients and the most frequent cause of death and disabilit… |
| ECT | Parisi et al · – | 2023 | Case Report | – | Haemostasis and Bleeding Control | 1 | – | bleomycin · intravenous | – | Breast Angiosarcoma is a rare malignancy, accounting less than 1% of all soft tissue. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS). Despite the… |
| ECT | Albertini et al · Case Rep Med | 2020 | Case Report | Human | – | 1 / 3 | Cliniporator VITAE | bleomycin · intravenous | partial response 30 days (1 patients) | Introduction Metastatic bone disease represents a systemic pathology that heavily affects the quality of life of oncologic patients causing pain and functional disability. Methodology . We p… |
| ECT | Cornelis et al · Cardiovasc Intervent Radiol | 2019 | Case Report | Human | – | 2 / 3 | Cliniporator VITAE | bleomycin · intravenous | – | Two patients underwent percutaneous image-guided electrochemotherapy on blastic spine metastases involving posterior walls of the lumbar vertebral bodies with epidural extension. These treat… |
| IRE | Qin et al · Technol Cancer Res Treat | 2017 | Case Report | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | 1 / 1 | NanoKnife | – | complete response 1 count (1 patients) | Purpose: To explore the safety and efficacy of irreversible electroporation ablation in unresectable fibrous sarcoma with 2 electrodes. Methods: A 74-year-old woman with unresectable retrope… |
| Other EP | Mocerino et al · Int J Immunopathol Pharmacol | 2016 | Case Report | Human | Increased Intracellular Bleomycin Accumulation | 1 | – | bleomycin · intravenous | – | Angiosarcomas are malignant tumors of endovascular origin, which may be divided into primary and secondary forms. Secondary breast angiosarcomas are an increasing problem, especially in pati… |
| IRE | Harris et al · J Pediatr Hematol Oncol | 2016 | Case Report | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | 1 / 1 | NanoKnife | – | – | Irreversible electroporation (IRE) induces apoptosis in tumor cells with electric energy, allowing treatment of unresectable tumors. One potential application is metastatic osteosarcoma (OS)… |
| IRE | Steinbrecher et al · BMJ Case Rep | 2016 | Case Report | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | 1 / 1 | – | – | complete response 1 count (1 patients) | Ewing's sarcoma (ES) is the second most common paediatric cancer of the bone. Standard therapy includes surgery or radiation for local control of primary and relapsed lesions and chemotherap… |
| ECT | Bonadies et al · Anticancer Res | 2015 | Case Report | Human | – | 1 / 1 | Cliniporator | bleomycin · intravenous | tumour volume change 0.5 cm³ (1 patients) | Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous sarcoma with high recurrence rate. Radical surgery is the treatment of choice, although in cosmetically-sensitive areas such a… |
| IRE | Neal et al · J Clin Oncol | 2011 | Case Report | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | – | NanoKnife | – | complete response 100% (1 patients) | Irreversible electroporation (IRE) is a promising technique for the focal treatment of pathologic tissues that involves placing minimally invasive electrodes within the targeted region. A se… |
| ECT | Shimizu et al · J Orthop Sci | 2003 | Case Report | Human | Increased Intracellular Bleomycin Accumulation, Necrosis and Necroptosis | 1 / 1 | Square Electroporator CUY-21 | bleomycin · both intravenous and intratumoural | overall survival 36 months (1 patients) | Electrochemotherapy (ECT) delivers nonpermeable anticancer drugs to cell interiors by temporally increasing the permeability of the cytoplasmic membrane under locally applied pulsating elect… |
| ECT | Deschamps et al · Br J Radiol | 2025 | Review | Human | Electric Field Distribution and Modelling | 3 | – | bleomycin · intravenous | – | This review aims to analyse the safety and clinical efficacy in terms of pain relief and local tumour control, in patients with metastatic epidural spinal cord compression undergoing electro… |
| Other EP | Berry-Kilgour · Front Bioeng Biotechnol | 2024 | Review | Literature Analysis | Preservation of Extracellular Matrix and Tissue Scaffold, Electric Field Distribution and Modelling | – | – | – | – | Tissue engineering encompasses a range of techniques that direct the growth of cells into a living tissue construct for regenerative medicine applications, disease models, drug discovery, an… |
| ECT | Parisi et al · J Clin Med | 2024 | Review | Literature Analysis | Haemostasis and Bleeding Control | 1 | – | bleomycin · intravenous | local control 1 count (1 patients) | Breast angiosarcoma is a rare malignancy, accounting for less than 1% of all soft tissue cancers. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS).… |
| ECT | Martin et al · Bioengineering (Basel) | 2023 | Review | Literature Analysis | Increased Intracellular Bleomycin Accumulation | 29 | – | bleomycin · intravenous | complete response 10 count (16 patients) | The primary aim of this study was to analyze studies that use electrochemotherapy (ECT) in "deep-seated" tumors in solid organs (liver, kidney, bone metastasis, pancreas, and abdomen) and un… |
| Other EP | Shu · Life (Basel) | 2023 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | – | – | – | – | Soft tissue tumors (STTs) include a range of benign and malignant tumors originating from soft tissues. Transarterial and percutaneous therapies are image-guided and minimally invasive appro… |
| IRE | Sun et al · Anticancer Res | 2023 | Review | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | – | – | – | – | Osteosarcoma is the most common primary bone malignancy, and surgical resection combined with neoadjuvant chemotherapy is the gold-standard treatment for affected patients. Although the over… |
| Other EP | Tsukamoto et al · Curr Oncol | 2021 | Review | Human | – | 102 | – | other · intravenous | – | The number of patients with bone metastasis increases as medical management and surgery improve the overall survival of patients with cancer. Bone metastasis can cause skeletal complications… |
| IRE | Sundararajan et al · JCPCR | 2019 | Review | Literature Analysis | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | 15 / 137 | – | bleomycin · intravenous | – | Volume 10 Issue 5 - 2019 Sarcomas are cancers that occur in soft tissues and bones that mostly affect teenagers and young adults. Although its occurrence is rare, the affect is huge-metastat… |
| IRE | Vailas et al · J BUON | 2019 | Review | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | – | – | – | – | Sarcomas arise from uncontrolled cell growth in tissues of mesodermal origins, such as connective tissue, bone, cartilage, fat or muscle. Surgical resection is still considered the cornersto… |
| Other EP | Mavrogenis et al · Clin J Pain | 2016 | Review | Human | – | – | – | bleomycin · intravenous | – | Background: Metastatic disease is the most common malignancy of the bone. Prostate, breast, lung, kidney, and thyroid cancer account for 80% of skeletal metastases. Bone metastases are assoc… |
| ECT | Spugnini et al · Int J Biochem Cell Biol | 2008 | Review | Animal (In Vivo) | – | – | – | bleomycin · intratumoural | – | Local management of soft tissue sarcoma in humans generally involves multi-modality approaches whose cornerstones are surgery combined with radiation therapy. The usual radiation protocols a… |
| ECT | Deschamps et al · Eur Radiol Exp | 2025 | Animal Study | Animal (In Vivo) | Haemostasis and Bleeding Control, Apoptosis Induction | – | Cliniporator VITAE | bleomycin · intravenous | – | Background: Electrochemotherapy (ECT) of vertebral metastasis is a new treatment option for metastasis that is not accessible to thermal ablation or radiotherapy. A numerical feasibility stu… |
| ECT | Kranjc et al · Radiol Oncol | 2017 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Reversible Membrane Permeabilisation | – | Jouan GHT 1287 | cisplatin · intratumoural | – | Background: Cisplatin is used in cancer therapy, but its side effects and acquired resistance to cisplatin have led to the synthesis and evaluation of new platinum compounds. Recently, the s… |
| IRE | Tschon et al · Technol Cancer Res Treat | 2016 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | – | – | – | – | Skeletal metastases are a common cause of severe morbidity, reduction in quality of life and often early mortality. Consequently, improvements in therapies are necessary. Electroporation use… |
| IRE | Tam et al · Radiology | 2016 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Electric Field Distribution and Modelling | – | NanoKnife | – | – | Purpose To determine the effects of irreversible electroporation (IRE) on the neural tissues after ablation in the epidural space of the porcine spine. Materials and Methods The institutiona… |
| ECT | Cemazar et al · Radiol Oncol | 2015 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Potentiation of Cytotoxic Drug Permeability | – | ELECTRO CELL B10 | cisplatin · intravenous | complete response 4 count (11 animals) | Background: Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their … |
| IRE | Song et al · Sci Rep | 2015 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | – | – | – | – | Irreversible electroporation (IRE) is a novel ablation method that has been tested in humans with lung, prostate, kidney, liver, lymph node and presacral cancers. As a new non-thermal treatm… |
| ECT | Fini et al · Clin Exp Metastasis | 2013 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | – | Cliniporator | bleomycin · intravenous | tumour volume change 75% (8 lesions) | Bone metastases impair general health status, quality of life and survival of patients. Electrochemotherapy (ECT), which combines electroporation (EP) and the administration of anticancer dr… |
| Gene ET | Sedlar · BMC Cancer | 2013 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Interleukin-12 Mediated Immune Stimulation | – | GT-01 | plasmid DNA · intratumoural | tumour volume change 7.1 cm³ (14 animals) | Background: Interleukin-12 (IL-12) based radiosensitization is an effective way of tumor treatment. Local cytokine production, without systemic shedding, might provide clinical benefit in ra… |
| Gene ET | Sedlar et al · Radiol Oncol | 2012 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Interleukin-12 Mediated Immune Stimulation | – / 232 | GT-01, Cliniporator | cisplatin · intratumoural | complete response 2 count (12 animals) | BACKGROUND.: Electrochemotherapy provides good local tumor control but requires adjuvant treatment for increased local response and action on distant metastasis. In relation to this, intramu… |
| IRE | Li et al · PLoS One | 2012 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | – | TP3032 | – | – | Background: Irreversible electroporation (IRE) is a promising technique for the focal treatment of pathologic tissues, which involves placing minimally invasive electrodes within the targete… |
| ECT | Spugnini et al · J Transl Med | 2011 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation | – | Chemipulse III portable electroporator | cisplatin · intratumoural | local recurrence 180 days (14 patients) | Background: Cancer is one of the most difficult current health challenges, being responsible for millions of deaths yearly. Systemic chemotherapy is the most common therapeutic approach, and… |
| Other EP | Fini et al · J Bone Joint Surg Br | 2010 | Animal Study | Animal (In Vivo) | – | – | Cliniporator | bleomycin | – | Short intense electrical pulses transiently increase the permeability of the cell membrane, an effect known as electroporation. This can be combined with antiblastic drugs for ablation of tu… |
| Gene ET | Grosel et al · DNA Cell Biol | 2006 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Increased Intracellular Cisplatin Accumulation | – | Jouan GHT 1287 | plasmid DNA · intratumoural | – | The aim of our study was to evaluate feasibility and therapeutic potential of electrogene therapy with p53 alone or combined with electrochemotherapy using cisplatin on two murine sarcomas w… |
| ECT | Spugnini et al · Cancer Chemother Pharmacol | 2006 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation | – | Chemopulse | bleomycin · intratumoural | local recurrence 12 months (19 patients) | Feline soft tissue sarcomas are spontaneous, rapidly growing, and aggressive neoplasms that mimic their human counterpart. The purpose of this study was to evaluate the feasibility and effic… |
| ECT | Kranjc et al · BMC Cancer | 2005 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | – | Jouan GHT 1287 | bleomycin · intravenous | local control 12.4% | Background: Bleomycin is poorly permeant but potent cytotoxic and radiosensitizing drug. The aim of the study was to evaluate whether a physical drug delivery system - electroporation can in… |
| ECT | Isobe et al · Clin Orthop Relat Res | 2004 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability | – | CUY-21, CUY-21 electroporator | other · intravenous | complete response 4 count (7 animals) | Methotrexate plays a key role in adjuvant chemotherapy for treatment of osteosarcoma, but is used at a high dose because it can pass through a cell membrane only with difficulty. Therefore, … |
| ECT | Jaroszeski et al · Technol Cancer Res Treat | 2002 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Reversible Membrane Permeabilisation | – | MedPulser | bleomycin · intratumoural | – | Electrochemotherapy is the combined use of a chemotherapeutic agent and pulsed electric fields. Electrical treatment causes an increase in cell membrane permeability which allows the chemoth… |
| Other EP | A Horiuchi, T Nikaido, J Mitsushita, T Toki, I Konishi, S Fujii · International Journal of Cancer | 2000 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Systemic / Abscopal Immune Response | – | Square Electroporator CUY-21 | bleomycin · intratumoural | – | Int. J. Cancer: 88, 640 – 644 (2000) © 2000 Wiley-Liss, Inc. Publication of the International Union Against Cancer ENHANCEMENT OF ANTITUMOR EFFECT OF BLEOMYCIN BY LOW-VOLTAGE IN VIVO ELECTRO… |
| ECT | M Hyacinthe, M Jaroszeski, V Dang, D Coppola, R Karl, R Gilbert · Cancer | 1999 | Animal Study | Animal (In Vivo) | Potentiation of Cytotoxic Drug Permeability, Increased Intracellular Bleomycin Accumulation | – | BTX T820, BTX 878-2a electrode, BTX 195-7460 switch | bleomycin · intratumoural | complete response 100% (12 lesions) | Pulsed electric fields have been shown to increase the effectiveness of antineoplastic agents by temporarily increasing the permeability of cell membranes. This type of drug delivery is call… |
| ECT | Sersˇa et al · Bioelectrochemistry and Bioenergetics | 1997 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Potentiation of Cytotoxic Drug Permeability | – | Jouan GHT 1287 | cisplatin · intravenous | complete response 20 count | Electrochemotherapy combines chemotherapy with electric pulses in order to potentiate anti-tumor effectiveness of chemotherapeutic drugs. Electrochemotherapy with drugs that normally do not … |
| ECT | Michel et al · Biotechnol Appl Biochem | 2019 | In Vitro Study | Cell Culture | Reversible Membrane Permeabilisation, Increased Intracellular Cisplatin Accumulation | – | BTX ECM830 | other | – | Primary cell cultures are challenging, but reliable model reflecting tumor response in vitro. The study was designed to examine if the increased electropermeabilization can overcame initial … |
| Other EP | Gill et al · Oncotarget | 2018 | In Vitro Study | Cell Culture | Increased Intracellular Cisplatin Accumulation | – | BTX electroporator | other | cell viability 90% | Background: Osteosarcoma accounts for roughly 60% of all malignant bone tumors in children and young adults. The five-year survival rate for localized tumors after surgery and chemotherapy i… |
| ECT | Cindrič et al · Cancers (Basel) | 2022 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Reversible Membrane Permeabilisation | – | – | – | – | Electroporation-based treatments such as electrochemotherapy and irreversible electroporation ablation have sparked interest with respect to their use in medicine. Treatment planning involve… |
| ECT | Cindrič et al · Technol Cancer Res Treat | 2018 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Electrode Geometry and Placement | – / 3 | – | – | tumour volume change 99.68% | Vertebral column is the most frequent site for bone metastases. It has been demonstrated in previous studies that bone metastases can be efficiently treated by electrochemotherapy. We develo… |
| ECT | Campana et al · Technol Cancer Res Treat | 2018 | In Silico / Modelling | Human | Electric Field Distribution and Modelling, Tissue Conductivity and Impedance Change | – | EPS02 | – | – | Electrochemotherapy is an established treatment option for patients with superficially metastatic tumors, mainly malignant melanoma and breast cancer. Based on preliminary experiences, elect… |
| ECT | Ongaro et al · Technol Cancer Res Treat | 2015 | In Silico / Modelling | Computational Model | Electric Field Distribution and Modelling, Electrode Geometry and Placement | – | – | bleomycin | – | Electrochemotherapy (ECT) is a local anticancer treatment based on the combination of chemotherapy and short, tumor-permeabilizing, voltage pulses delivered using needle electrodes or plate … |
| ECT | Tosi et al · Med Biol Eng Comput | 2016 | Experimental Biophysics Study | Human | Tissue Conductivity and Impedance Change | 19 / 19 | Cliniporator | – | – | Tissue electrical conductivity is correlated with tissue characteristics. In this work, some soft tissue sarcomas (STS) excised from patients have been evaluated in terms of histological cha… |
| Calcium EP | Szewczyk · Oncotarget | 2019 | Correction / Erratum | – | Calcium Electroporation and ATP Depletion | – | – | calcium chloride | – | [This corrects the article DOI: 10.18632/oncotarget.24352.]. |
No publication matches these filters.
Limitations
Publication volume is not clinical efficacy or evidence quality. It describes how much literature exists in the area and of what kind; it does not indicate how strongly the treatment is supported, guideline endorsement or regulatory status.
Patient totals are not a count of unique patients. The same cohort may have been reported in more than one publication; the totals are not a meta-analysis.
How the corpus was assembled, the tier thresholds, the definition of a clinical publication and why methods are counted separately: Literature Map.