Prostat ve Ürolojik Tümörler
Ürojinekolojik Tümörler
Prostatta odaksal tedavi arayışı, üriner ve seksüel fonksiyonu koruma hedefiyle şekillenmiştir. Korpusta hem reversible hem irreversible rejime ait yayınlar bulunur; kanıtın büyük bölümü karşılaştırmasız serilerden gelmektedir.
120toplam yayın
56klinik çalışma
25preklinik çalışma
24derleme
1998–2026yayın aralığı
Rejime Göre Kanıt Durumu
Reversible elektroporasyon (RE-ECT)
24yayın
1klinik
15preklinik
Preklinik Kanıt
1998–2026 · Klinik Araştırma Aşamasında
İrreversible elektroporasyon (IRE-ECT)
96yayın
55klinik
10preklinik
Klinik Kanıt
2007–2026 · Rutin Klinik Kullanımda
Bu Alanda Raporlanan Mekanizmalar
Terimler, yayın özetleri üzerinde otomatik eşleştirmeyle saptanmıştır; rakam terimin geçtiği yayın sayısını gösterir.
Reversible Membran Permeabilizasyonu 100
İrreversible Por Oluşumu ve Hücre Ölümü 100
Elektrik Alan Dağılımı ve Modellemesi 9
Termal Etki ve Joule Isınması 9
Nekroz ve Nekroptoz 8
Darbe Parametrelerinin Optimizasyonu 7
Bleomisin Hücre İçi Birikiminin Artması 6
Sisplatin Hücre İçi Birikiminin Artması 5
Apoptoz İndüksiyonu 5
Kas Kasılması ve Anestezi Gereksinimi 4
Kalsiyum Elektroporasyonu ve ATP Tükenmesi 3
Sistemik / Abskopal İmmün Yanıt 3
Çalışma Tipi Dağılımı
Çubuk uzunluğu en kalabalık çalışma tipine göre ölçeklenmiştir; yüzde ise alanın tamamındaki payı verir. Renk, çalışma tipinin kanıt basamağını gösterir; kanıt haritasındaki ile aynı ölçek.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Randomize Klinik Çalışma | 9 | %8 |
| Prospektif Klinik Çalışma | 5 | %4 |
| Klinik Çalışma | 28 | %23 |
| Retrospektif Klinik Çalışma | 6 | %5 |
| Vaka Serisi | 8 | %7 |
| Vaka Raporu | 5 | %4 |
| Sistematik Derleme / Meta-Analiz | 10 | %8 |
| Derleme | 14 | %12 |
| Hayvan Çalışması | 19 | %16 |
| İn Vitro Çalışma | 5 | %4 |
| İn Siliko / Modelleme | 1 | <%1 |
| Ön Baskı | 4 | %3 |
| Editöryal / Mektup | 4 | %3 |
| Protokol | 2 | %2 |
Literatür Kanıt Tablosu
120 yayın, kanıt gücü sırasına göre listelenmiştir. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Özet |
|---|---|---|---|---|---|---|
| İrreversible | He et al · EClinicalMedicine | 2026 | Randomize Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Transurethral resection of the prostate (TURP) is the gold standard for treating benign prostatic hyperplasia (BPH) but frequently causes retrograde ejaculation and bleeding. Hig… |
| İrreversible | Tong et al · Urology | 2025 | Randomize Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Objective: To evaluate the efficacy and safety of high-frequency irreversible electroporation for ablation of benign prostatic hyperplasia. Materials and methods: One hundred sixty subjects … |
| İrreversible | Zhang et al · BJU Int | 2025 | Randomize Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objective: To investigate the diagnostic value of magnetic resonance imaging (MRI) for persistent prostate cancer after irreversible electroporation (IRE) therapy. Patients and methods: This… |
| İrreversible | Lantz et al · Eur Urol Open Sci | 2023 | Randomize Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The aim of focal treatments (FTs) in prostate cancer (PCa) is to treat lesions while preserving surrounding benign tissue and anatomic structures. Irreversible electroporation (IRE) is a non… |
| İrreversible | Zhang et al · JAMA Surg | 2023 | Randomize Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Importance: Focal ablative irreversible electroporation (IRE) is a therapy that treats only the area of the tumor with the aim of achieving oncological control while reducing treatment-relat… |
| İrreversible | de la Rosette et al · J Urol | 2023 | Randomize Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose: Our goal was to evaluate the effect of focal vs extended irreversible electroporation on side effects, patient-reported quality of life, and early oncologic control for localized lo… |
| İrreversible | Scheltema et al · BMC Cancer | 2016 | Randomize Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Current surgical and ablative treatment options for prostate cancer (PCa) may result in a high incidence of (temporary) incontinence, erectile dysfunction and/or bowel damage. Th… |
| İrreversible | van den Bos et al · J Endourol | 2015 | Randomize Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | FOR LOCALIZED PROSTATE CANCER: FOCAL ABLATION VERSUS EXTENDED ABLATION Willemien van den Bos and Jean de la Rosette Focal therapy in prostate cancer Focal therapy is gradually emerging as a … |
| İrreversible | de la Rosette et al · J Endourol | 2013 | Randomize Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | PROSTATE CARCINOMA: HEMIABLATION VERSUS COMPLETE ABLATION WITH IRREVERSIBLE ELECTROPORATION W. van den Bos, B.G. Muller, and J.J.C.M.H. de la Rosette Focal therapy in prostate cancer Focal t… |
| İrreversible | Blazevski et al · Eur Urol Oncol | 2020 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Focal irreversible electroporation (IRE) can be used to treat men with localised prostate cancer (PCa) with reduced impact on quality of life (QoL). Objective: To assess oncologi… |
| İrreversible | Enikeev et al · Minerva Urol Nefrol | 2020 | Prospektif Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | article: Focal irreversible electroporation for localized prostate cancer management: prospective assessment of efficacy and safety - Minerva Urologica e Nefrologica 2020 October;72(5):644-5… |
| İrreversible | Scheltema et al · BJU Int | 2017 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: To evaluate the feasibility, safety, early quality-of-life (QoL) and oncological outcomes of salvage focal irreversible electroporation (IRE) for radio-recurrent prostate cancer … |
| İrreversible | Murray et al · J Urol | 2016 | Prospektif Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose: Partial prostate gland ablation is a strategy to manage localized prostate cancer. Irreversible electroporation can ablate localized soft tissues. We describe 30 and 90-day complica… |
| İrreversible | Valerio et al · Contemp Clin Trials | 2014 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: Focal therapy may reduce the toxicity of current radical treatments while maintaining the oncological benefit. Irreversible electroporation (IRE) has been proposed to be tissue… |
| İrreversible | George et al · Eur Urol | 2026 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background and objective: The PRESERVE study (NCT04972097) assessed the safety and effectiveness of irreversible electroporation (IRE) with the NanoKnife System to ablate prostate tissue in … |
| İrreversible | McClure et al · Radiology | 2026 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background Irreversible electroporation (IRE) is a nonthermal local therapy for prostate cancer (PCa). However, the feasibility, outcomes, and safety of reduced-dose radiation therapy (RT) f… |
| İrreversible | Yu et al · Medicine (Baltimore) | 2025 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | This study evaluates the efficacy and safety of IRE (irreversible electroporation) ablation in the management of BPH (benign prostatic hyperplasia). Clinical data from 9 patients with prosta… |
| İrreversible | Diven · BMC Urol | 2024 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: Radiation Therapy and IRreversible Electroporation for Intermediate Risk Prostate Cancer (RTIRE) is a phase II clinical trial testing combination of radiation therapy and irrev… |
| İrreversible | Geboers et al · BJU Int | 2024 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: To prospectively compare systemic anti-tumour immune responses induced by irreversible electroporation (IRE) and robot-assisted radical prostatectomy (RARP) in patients with loca… |
| İrreversible | George et al · Cancers (Basel) | 2024 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The PRESERVE study (NCT04972097) aims to evaluate the safety and effectiveness of the NanoKnife System to ablate prostate tissue in patients with intermediate-risk prostate cancer (PCa). The… |
| İrreversible | Blazevski et al · BJU Int | 2023 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: To prospectively assess the safety, functional- and oncological-outcomes of irreversible electroporation (IRE) as salvage therapy for radio-recurrent focal prostate cancer in a m… |
| İrreversible | CIMIT uzman grubu · Zhonghua Yi Xue Za Zhi | 2023 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Irreversible electroporation ablation therapy can destroy tumor cells while retaining the integrity of the important surrounding physiological structures. It is suitable for patients with re… |
| İrreversible | Diven et al · International Journal of Radiation Oncology*Biology*Physics | 2023 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | mediate Risk Prostate Cancer (RTIRE) e378 Poster Q&A Sessions International Journal of Radiation Oncology Biology Physics Author Disclosure: M. Diven: None. T.D. McClure: None. K. Ballma… |
| İrreversible | Geboers et al · BJU Int | 2023 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: To evaluate the safety, and short to mid-term oncological and quality-of-life (QoL) outcomes of focal irreversible electroporation (IRE) for radio-recurrent prostate cancer (PCa)… |
| İrreversible | Shin et al · Prostate Int | 2023 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: To demonstrate the clinical usefulness of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) computerized tomography (CT) for irreversible electroporati… |
| İrreversible | Aycock et al · J Biomech Eng | 2022 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | While the primary goal of focal therapy for prostate cancer (PCa) is conserving patient quality of life by reducing oncological burden, available modalities use thermal energy or whole-gland… |
| İrreversible | Geboers et al · Eur Urol Focus | 2022 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Accurate monitoring following focal treatment of prostate cancer (PCa) is paramount for timely salvage treatment or retreatment. Objective: To evaluate the diagnostic accuracy of… |
| İrreversible | Scheltema et al · BJU Int | 2022 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: To evaluate longer-term oncological and functional outcomes of focal irreversible electroporation (IRE) as primary treatment for localised clinically significant prostate cancer … |
| İrreversible | Güleryüz Kızıl et al · Turk J Urol | 2021 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objective: To evaluate early clinical and multiparametric prostate magnetic resonance imaging (mpMRI) results of irreversible electroporation (IRE) efficiency in treatment of localized prost… |
| İrreversible | Blazevski et al · World J Urol | 2020 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction and objective: To assess the safety, oncological and quality-of-life (QoL) outcomes of focal ablation of apical prostate cancer (PCa) lesions with irreversible electroporation (… |
| İrreversible | Collettini et al · Radiology | 2019 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background Irreversible electroporation (IRE) is a nonthermal ablative method based on the formation of nanoscale defects in cell membranes leading to cell death. Clinical experience with th… |
| İrreversible | Dong et al · Technol Cancer Res Treat | 2018 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Irreversible electroporation, as a nonthermal therapy of prostate cancer, has been used in clinic for several years. The mechanism of irreversible electroporation ablation is thermal indepen… |
| İrreversible | Garvan Institute et al · Diagn Interv Radiol | 2018 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: We aimed to evaluate the genitourinary function and quality of life (QoL) following the ablation of different prostate segments with irreversible electroporation (IRE) for localized… |
| İrreversible | Wendler et al · Urology | 2018 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objective: To assess the efficacy of irreversible electroporation (IRE) ablation of pT1a renal cell carcinoma (RCC) in the first prospective, monocentric phase 2a pilot ablate-and-resect stu… |
| İrreversible | Valerio et al · J Urol | 2017 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose: Irreversible electroporation has attractive attributes for focal ablation, namely nonthermal effect, precise demarcation of treatment and tissue selectivity. We report a prospective… |
| İrreversible | van den Bos et al · BJU Int | 2017 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: To determine the safety, quality of life (QoL) and short-term oncological outcomes of primary focal irreversible electroporation (IRE) for the treatment of localized prostate can… |
| İrreversible | van den Bos et al · J Urol | 2016 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose: Irreversible electroporation is a tissue ablation modality that uses high voltage electric energy to induce an increase in cell membrane permeability. This causes destabilization of… |
| İrreversible | Ting et al · Prostate Cancer Prostatic Dis | 2015 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Current data on the use of irreversible electroporation (IRE) in the treatment of prostate cancer (PCa) is limited. We aim to evaluate the safety, short-term functional and oncol… |
| İrreversible | Wendler et al · Contemp Clin Trials | 2015 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: Focal ablation therapy is playing an increasing role in oncology and may reduce the toxicity of current surgical treatments while achieving adequate oncological benefit. Irreve… |
| İrreversible | Wendler et al · Cardiovasc Intervent Radiol | 2015 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: It is postulated that focal IRE affords complete ablation of soft-tissue tumours while protecting the healthy peritumoral tissue. Therefore, IRE may be an interesting option fo… |
| İrreversible | van den Bos et al · Eur Radiol | 2015 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: Irreversible electroporation (IRE) is an ablative therapy with a low side-effect profile in prostate cancer. The objective was: 1) To compare the volumetric IRE ablation zone on … |
| İrreversible | van den Bos et al · BMJ Open | 2014 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: Current surgical and ablative treatment options for prostate cancer have a relatively high incidence of side effects, which may diminish the quality of life. The side effects a… |
| Reversible | Stevanovic et al · Radiol Oncol | 2025 | Retrospektif Klinik Çalışma | İnsan | – | Background: Prostate cancer (PCa) is a common cancer in men in developed countries. PCa treatment depends on the disease's stage; focal therapy provides an intermediate approach, with lower … |
| İrreversible | van Riel et al · BJU Int | 2022 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objective: To evaluate: (i) safety, (ii) feasibility, and medium-term (iii) oncological and (iv) functional outcomes of salvage radical prostatectomy (sRP) for recurrent localised prostate c… |
| İrreversible | Guenther et al · PLoS One | 2019 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Irreversible Electroporation (IRE) is a novel image-guided tissue ablation technology that induces cell death via very short but strong pulsed electric fields. IRE has been shown… |
| İrreversible | Scheltema et al · Eur Urol Focus | 2019 | Retrospektif Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: It is recommended to perform multiparametric magnetic resonance imaging (mpMRI) in the follow-up following focal therapy of prostate cancer (PCa). Objective: To determine the dia… |
| İrreversible | Beyer et al · Clin Hemorheol Microcirc | 2017 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: Irreversible electroporation (IRE) is a focal non-thermal ablation technique that can be used to treat prostate cancer (Pca). The objective was to document the evolution of the volu… |
| İrreversible | Niessen et al · Clin Hemorheol Microcirc | 2015 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: To evaluate the use of contrast-enhanced ultrasound (CEUS) after irreversible electroporation (IRE) of prostatic cancer tissue to assess the ablation status by depicting microvascul… |
| İrreversible | Altan et al · Eur J Radiol | 2026 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Detecting recurrence after focal therapy for prostate cancer is challenging due to treatment-induced MRI changes and unreliable PSA kinetics. The Prostate Imaging after Focal Abl… |
| İrreversible | Noakes et al · Prostate | 2026 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Local recurrence after definitive radiotherapy for prostate cancer (PCa) remains a challenging clinical problem. Salvage irreversible electroporation (sIRE) is a non-thermal foca… |
| İrreversible | Sandberg et al · Curr Oncol | 2025 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Focal therapy for prostate cancer (PCa) provides approaches to treat PCa patients in a less invasive manner than traditional whole-gland surgical or radiation modalities. This manuscript pro… |
| İrreversible | Fainberg et al · Urol Pract | 2024 | Vaka Serisi | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Introduction: We studied patient-reported functional outcomes, safety, and oncologic efficacy of focal irreversible electroporation as a primary treatment for intermediate-risk prostate canc… |
| İrreversible | Yaxley et al · Investig Clin Urol | 2022 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: Focal irreversible electroporation (IRE) for prostate cancer aims to reduce quality of life complications, however outcomes data remains limited. We aimed to evaluate histological i… |
| İrreversible | Wendler et al · European Urology Supplements | 2017 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | & OBJECTIVES: To evaluate the feasibility, adverse event profile, functional outcome and efficacy of focal irreversible electroporation (IRE) for pT1a renal cell carcinoma (RCC) in consecuti… |
| İrreversible | van den Bos et al · World J Urol | 2015 | Vaka Serisi | İnsan | Elektrot Geometrisi ve Yerleşimi, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose: Irreversible electroporation (IRE) is a novel minimally invasive therapy for prostate cancer using short electric pulses to ablate prostate tissue. The purpose of this study is to d… |
| İrreversible | Valerio et al · Prostate Cancer Prostatic Dis | 2014 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: To evaluate the safety and clinical feasibility of focal irreversible electroporation (IRE) of the prostate. Methods: We assessed the toxicity profile and functional outcomes of … |
| İrreversible | Hertz et al · Transl Androl Urol | 2025 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Optilume-drug coated balloon as emerged as a less invasive management of recurrent bulbar urethral strictures. Data is still emerging in terms of its efficacy with regards to oth… |
| İrreversible | Collettini et al · Cardiovasc Intervent Radiol | 2024 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | ectroporation for Localized Prostate Cancer Federico Collettini1,3 • Carsten Stephan2,4 • Thomas Fischer1 • Andreas Maxeiner2 • Timo Alexander Auer1,3 • Bernhard Gebauer1 Received: 1 May 202… |
| İrreversible | Ong et al · BMJ Case Rep | 2022 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | A man in his 50s presented 4-week postirreversible electroporation (IRE) for low-to-intermediate risk prostate cancer with urinary symptoms, diarrhoea and passing fluid per rectum when urina… |
| Reversible | Andresciani et al · Cardiovasc Intervent Radiol | 2020 | Vaka Raporu | İnsan | – | A 61-year-old female underwent a right radical nephrectomy and a left nephron sparing surgery in 2014 due to renal cell carcinoma. A renal cell carcinoma local recurrence, 28 mm in size, cen… |
| Reversible | Klein et al · Clin Case Rep | 2017 | Vaka Raporu | İnsan | – | We demonstrate feasibility and safety of Electrochemotherapy for treatment of a prostate cancer (PCa) with infiltration of the urethral sphincter. The patient remained continent and potent, … |
| Reversible | Eskandar · Actas Urológicas Españolas | 2025 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | Focal therapy offers a middle-ground approach for localized prostate cancer, preserving the prostate while avoiding the morbidity of radical treatment. High-Intensity Focused Ultrasound (HIF… |
| İrreversible | Dan et al · Medicine (Baltimore) | 2025 | Sistematik Derleme / Meta-Analiz | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: Laparoscopic partial nephrectomy (LPN) and laparoscopic focal therapy (LFT) have emerged as minimally invasive alternatives for managing small renal masses. Despite their increas… |
| İrreversible | Jochumsen et al · Nucl Med Mol Imaging | 2025 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | Cancer After Nanoknife Electroporation Ablation Diagnosed with PSMA PET/ MRI Mads Ryø Jochumsen1,2,3 · Lise Medrud4 · Lars Anders Høst5 · Peter Iversen1,2 Received: 19 December 2024 / Revise… |
| İrreversible | Piramide et al · Minerva Urol Nephrol | 2025 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: In the latest years the advent of minimally invasive focal treatment for prostate cancer (PCa) has gained a wide diffusion. Different platforms and sources of energy have been … |
| İrreversible | Skribek et al · Cancers (Basel) | 2025 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background and objective: Minimally invasive interventions, including irreversible electroporation (IRE), cryoablation, and high-intensity focused ultrasound (HIFU), offer promising alternat… |
| İrreversible | Yilmaz et al · Prostate Cancer Prostatic Dis | 2024 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: To systematically evaluate the available evidence regarding the effect of salvage irreversible electroporation (IRE) in patients with local recurrent prostate cancer (PCa) after … |
| İrreversible | Cribbs et al · Urology | 2023 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: To assess the comparative safety and effectiveness of 2 prostate cancer treatment ablation modalities: irreversible electroporation (IRE) and high-intensity focused ultrasound (H… |
| İrreversible | Guo et al · Int J Clin Oncol | 2021 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Cryoablation (CA), high-intensity focused ultrasound (HIFU), irreversible electroporation (IRE), and vascular-targeted photodynamic therapy (VTP) have been evaluated as novel strategies for … |
| İrreversible | Morozov et al · Andrologia | 2020 | Sistematik Derleme / Meta-Analiz | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Irreversible electroporation is a treatment option used for focal therapy. In this systematic review, we summarise data on irreversible electroporation outcomes in patients with localised pr… |
| İrreversible | Yoon et al · Medicine (Baltimore) | 2018 | Sistematik Derleme / Meta-Analiz | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: Robot-assisted partial nephrectomy (RPN) and focal therapy (FT) have both been successfully employed in the management of small renal masses. However, despite this being the era … |
| İrreversible | Xiao et al · Transl Androl Urol | 2026 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background and objective: Prostate cancer (PCa) endangers male health, with conventional treatments limited by poor efficacy and high complications. Irreversible electroporation (IRE) is a n… |
| Reversible | Lai · Radiol Imaging Cancer | 2025 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | In this era of personalized precision medicine, the accuracy of multiparametric MRI (mpMRI) and targeted biopsy in helping detect low-volume clinically significant prostate cancer has rekind… |
| İrreversible | Pow-Sang et al · Arch Esp Urol | 2025 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | The first description of focal therapy (FT) for prostate cancer was by Gary Onik when he described the use of hemigland cryoablation. Currently, focal therapy is performed using different en… |
| İrreversible | Torres · Front Radiol | 2025 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Percutaneous ablation therapies currently play a major role in the management of T1a and T1b renal cell carcinoma (RCC). These therapies include thermal ablative technologies like radiofrequ… |
| Reversible | Kumar et al · Can Urol Assoc J | 2024 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Introduction: Focal therapy is an emerging treatment for localized prostate cancer (PCa). The objectives of this review were to: 1) review how focal therapies are regulated and approved; 2) … |
| İrreversible | Faiella et al · Cancers (Basel) | 2024 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: Focal therapy is a promising, minimally invasive method for the treatment of patients with localized prostate cancer. According to the existing literature, there is growing evide… |
| İrreversible | Liu · Discov Oncol | 2024 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation is a nonthermal ablation technique that uses a high-voltage electric current to create nanosized pores in the cell membrane of a malignant tumor, thus resulting … |
| Reversible | Kiełbik et al · Cancers (Basel) | 2020 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The observation that an application of a pulsed electric field (PEF) resulted in an increased permeability of the cell membrane has led to the discovery of the phenomenon called electroporat… |
| İrreversible | Karagiannis et al · Curr Urol Rep | 2019 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose of review: Although still considered experimental, focal irreversible electroporation (IRE) as a primary treatment for prostate cancer (PCa) is considered one of the most promising a… |
| İrreversible | Lodeizen et al · World J Urol | 2018 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Context: In recent years, focal therapy has emerged as a treatment option for a selected group of men with localized prostate cancer. Cryotherapy and high-intensity focused ultrasound (HIFU)… |
| İrreversible | Stehling et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE), since its first introduction into the medical field in 2005, is gaining importance as a tissue ablation method. Being basically nonthermal, IRE destroys cel… |
| İrreversible | Narayanan et al · Curr Urol Rep | 2016 | Derleme | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Small renal masses (SRMs) have been traditionally managed with surgical resection. Minimally invasive nephron-sparing treatment methods are preferred to avoid harmful consequences of renal i… |
| İrreversible | Valerio et al · Tech Vasc Interv Radiol | 2015 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Focal therapy is a novel strategy that attempts to enhance the therapeutic ratio of standard radical treatment in prostate cancer. Irreversible electroporation (IRE) has some inherent charac… |
| Reversible | Bozzini et al · Urol Oncol | 2013 | Derleme | İnsan | Termal Etki ve Joule Isınması | Purpose: Over the last years, focal therapy has emerged as an intermediate management technique between radical approaches (radical prostatectomy, external beam radiation, and brachytherapy)… |
| Reversible | Guo · PLoS One | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Sisplatin Hücre İçi Birikiminin Artması | Nanosecond Pulsed Electric Field (nsPEF) is an intense electrical pulse technology with ultra-short duration (nanoseconds), capable of generating electric field intensities up to several kV/… |
| İrreversible | Xia et al · J Immunother Cancer | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE), a non-thermal focal therapy, employs high-frequency electrical pulses to create tumor cell membrane nanopores, inducing immunogenic cell death. By trigger… |
| İrreversible | Kim · Sci Rep | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Darbe Parametrelerinin Optimizasyonu | Irreversible electroporation (IRE) is a non-thermal ablation technique for local tumor treatment known to be influenced by pulse duration and voltage settings, affecting its efficacy. This s… |
| İrreversible | Xing et al · Transl Androl Urol | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: Ablation procedures have garnered significant attention as a minimally invasive treatment of prostate diseases. However, the feasibility and safety of applying high-frequency irr… |
| Reversible | Rangel et al · Sci Rep | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sistemik / Abskopal İmmün Yanıt | Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of the cases invade the muscular layer, more than 50% develop on bladder sites with a difficu… |
| İrreversible | Rojo et al · Int J Hyperthermia | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Metastatic prostate cancer in bone is difficult to treat as the tumor cells are relatively resistant to hormonal or chemotherapies when compared to primary prostate cancer. Irrev… |
| Reversible | Frandsen · PLoS One | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Nekroz ve Nekroptoz | Background: Calcium electroporation is a new experimental anti-cancer treatment where calcium is internalized into cells by application of short, high voltage pulses. Calcium electroporation… |
| Reversible | Hansen et al · PLoS One | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Elektrik Alan Dağılımı ve Modellemesi | Background: Electroporation, a method for increasing the permeability of membranes to ions and small molecules, is used in the clinic with chemotherapeutic drugs for cancer treatment (electr… |
| Reversible | Vásquez et al · J Urol | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | Purpose: Electrochemotherapy is widely performed to treat solid tumors but experience with bladder cancer is limited. We investigated mitomycin C and cisplatin administered with electrochemo… |
| İrreversible | Neal et al · Cardiovasc Intervent Radiol | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | Purpose: Electroporation-based therapies deliver brief electric pulses into a targeted volume to destabilize cellular membranes. Nonthermal irreversible electroporation (IRE) provides focal … |
| Reversible | Vásquez et al · Bioelectrochemistry | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | Intravesical mitomycin instillation combined with electric pulses is being used experimentally for the treatment of T1 bladder tumors, in patients unfit for surgery. Electroporation may enha… |
| İrreversible | Qin et al · Ann Biomed Eng | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) has been proposed to destroy large amounts of tumorous tissue and shows advantages over thermal therapies. Unfortunately, carefully constructed studies ass… |
| İrreversible | Deodhar et al · Urology | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Ekstraselüler Matriks ve Doku İskeletinin Korunması | Objectives: To evaluate the histopathologic and computed tomography imaging features associated with irreversible electroporation (IRE) ablation performed in normal porcine kidneys. IRE is a… |
| Reversible | Goepfert et al · Prostate | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu | Background: Current therapies to treat prostate cancer are often limited. Since it has been shown that very low concentrations of diphtheria toxin A (DT-A) result in abrogation of protein sy… |
| Reversible | Gothelf et al · Gene Ther | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | In development of novel vaccines, attention is drawn to DNA vaccinations. They are heat stable and can be easily produced. Gene electrotransfer is a simple and nonviral means of transferring… |
| Reversible | Ahmad et al · Mol Ther | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Prostate stem cell antigen (PSCA) is a cell surface antigen expressed in normal human prostate and over expressed in prostate cancer. Elevated levels of PSCA protein in prostate cancer corre… |
| İrreversible | Onik et al · Technol Cancer Res Treat | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Percutaneous prostate cryo-ablation has become an accepted treatment for primary prostate cancer. Thermal tissue ablation based on cold, however, does have some distinct limitations. These i… |
| Reversible | Mitsui et al · Int J Clin Oncol | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Background. We aimed to assess a new approach to cancer therapy, using pulsed electric fields to facilitate the delivery of chemotherapeutic drugs. Methods. We investigated the cytotoxic eff… |
| Reversible | Kubota et al · Eur Urol | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Objective: The aim of this study was to examine the usefulness of an electropermeabilization method in the administration of a chemotherapeutic agent in bladder cancer in the rat. Materials … |
| Reversible | Vizcarra-Ramos et al · Pharmaceutics | 2024 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Prostate cancer is a significant global health problem, being the second most common cancer and the fifth leading cause of death in men worldwide. Standard chemotherapy, though effective, of… |
| Reversible | Kiełbik et al · Sci Rep | 2021 | İn Vitro Çalışma | Hücre Kültürü | Nanosaniye Darbeli Elektrik Alan (nsPEF), Apoptoz İndüksiyonu | Electroporation with pulsed electric fields show a potential to be applied as an experimental focal therapy of tumors. Sub-microsecond regime of electric pulses displays unique electrophysic… |
| Reversible | Kiełbik · Molecules | 2020 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, İrreversible Por Oluşumu ve Hücre Ölümü | Electroporation, applied as a non-thermal ablation method has proven to be effective for focal prostate treatment. In this study, we performed pre-clinical research, which aims at exploring … |
| İrreversible | Rubinsky et al · J Urol | 2008 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: Irreversible electroporation is a new tissue ablation technique that consists of applying musecond pulses of direct current to create permanent defects in the cell membrane. Irrever… |
| Reversible | Sauer et al · Br J Cancer | 1999 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Elektrik Alan Dağılımı ve Modellemesi | Electrochemotherapy (ECT) is a new approach to the treatment of tumours. In the present study, multicellular prostate tumour spheroids were treated with non-lethal direct current (DC) electr… |
| İrreversible | van Gemert et al · Prostate | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Irreversible electroporation (IRE) is (virtually) always called non-thermal despite many reports showing that significant Joule heating occurs. Our first aim is to validate with … |
| İrreversible | Coleman et al · – | 2026 | Ön Baskı | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The PRESERVE trial ( NCT04972097 ) is a prospective, single-arm pivotal IDE study evaluating focal irreversible electroporation (IRE) using the NanoKnife System for intermediate-risk prostat… |
| İrreversible | Xia et al · – | 2024 | Ön Baskı | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background Prostate cancer is a prevalent condition among elderly males, with radical prostatectomy being the standard treatment. However, this procedure can inevitably impact urinary and se… |
| Reversible | Rangel et al · – | 2023 | Ön Baskı | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of cases arise as muscle-invasive tumors, with more than 50% developing on bladder sites with… |
| İrreversible | Zhang et al · – | 2023 | Ön Baskı | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | BACKGROUND Irreversible electroporation (IRE) is a novel technique to treat localized prostate cancer with the aim of achieving oncological control while reducing related side effects. We pr… |
| İrreversible | Scheltema et al · Eur Urol | 2026 | Editöryal / Mektup | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | of IRE for localised IR-PC. As clinical urologists, it is now arguably hard to explain our inability to offer IRE to patients with clear indications for focal treatment, such as patients wit… |
| İrreversible | Gebauer et al · J Vasc Interv Radiol | 2017 | Editöryal / Mektup | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Prostate Cancer following Radical Prostatectomy and Salvage Radiation Therapy From: Bernhard Gebauer, MD Judith Enders, MD Alexander D.J. Baur, MD Bernd Hamm, MD Federico Collettini, MD B.G.… |
| İrreversible | Wendler et al · Cardiovasc Intervent Radiol | 2016 | Editöryal / Mektup | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | cific Pretreatment Simulation by Electric Field Measurement in a 3D Bioprinted Textured Prostate Cancer Model to Achieve Optimal Electroporation Parameters for Image-Guided Focal Ablation Jo… |
| İrreversible | Fenner · Nat Rev Urol | 2014 | Editöryal / Mektup | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | RESEARCH HIGHLIGHTS PROSTATE CANCER Irreversible electroporation is a safe and feasible option for focal therapy A small clinical study from groups in London and Sydney has shown that irreve… |
| İrreversible | te Molder et al · BMJ Open | 2026 | Protokol | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: Intermediate-risk prostate cancer (PCa) is currently managed with radical whole-gland therapies, such as radical prostatectomy (RP) or radiotherapy (RT). While effective, these t… |
| İrreversible | Marra · Front Surg | 2022 | Protokol | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: Currently, the majority of prostate cancer (PCa) recurrences after non-surgical first-line treatment are managed with androgen-deprivation therapy (ADT). Salvage radical prosta… |
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