Grup: Deri ve Yüzeyel Tümörler
Cilt ve Kutanöz Tümörler
Bu portalın korpusunda elektrokemoterapinin en geniş literatürüne sahip endikasyon grubudur. Deri ve deri altındaki tümörler; yüzeyel yerleşimleri, elektrotlarla kolay erişilebilir olmaları ve yanıtın gözle izlenebilmesi nedeniyle yöntemin ilk ve korpusta en yoğun çalışılan klinik uygulama alanını oluşturur. Bazal hücreli karsinom, skuamöz hücreli karsinom ve çeşitli primer tümörlerin deri metastazları bu başlık altında toplanır.
210yayın kaydıtekilleştirildiğinde 209 bağımsız çalışma
126klinik yayın kaydı
29preklinik yayın kaydı
37derleme
1996–2026yayın aralığı
Klinik yayın: randomize, prospektif ve retrospektif çalışma, vaka serisi ve vaka raporu. Preklinik yayın: hayvan, in vitro, modelleme ve deneysel biyofizik çalışmaları.
Bu Alanda Sağlık Teknolojisi Değerlendirmeleri
Bu portal literatürün hacmini sayar; bir işlemin etkili olup olmadığını değerlendirmez. Aşağıdaki kurumlar bu değerlendirmeyi yapar ve sonuçları literatürün hacminden bağımsızdır: geniş bir literatür, kanıtın yeterli bulunduğu anlamına gelmez.
- NICE · 2014 · Primer bazal ve skuamöz hücreli karsinomda elektrokemoterapi (HealthTech htg333, eski IPG478)
- NICE · 2014 · Primer bazal ve skuamöz hücreli karsinomda elektrokemoterapi (IPG478 ilk PDF sürümü, 8 s.)
- NICE · 2013 · Cilt metastazlarında elektrokemoterapi (HealthTech htg305, eski IPG446)
Belgelerin tamamı ve künyeleri Düzenleyici Belgeler sayfasındadır. Portal bu raporların sonucunu kendi adına yorumlamaz; güncel karar için ilgili kurumun kendi yayınına bakınız.
Yayınların Bildirdiği Klinik ve Teknik Veriler
Bu alandaki 210 yayının tam metninde bildirilen alanların toplamı. Sayılar toplanır, yorumlanmaz.
Yayınlarda bildirilen hasta sayılarının toplamı13.899 (127 yayında bildirilmiş)
Kohortu başka yayınlarla ilişkilendiren yayınkohort örtüşmesi olabilir (7)
Bildirilen toplam lezyon36.418 (102 yayında)
Kullanılan cihazlar (cihaz adı bildiren 104 yayın)Cliniporator (62) · Cliniporator VITAE (7) · BTX ECM830 (5) · Onkodisruptor (5) · MedPulser (4) · ePORE (4)
Taşınan ajan ve yol (ajan bildiren 185 yayın)bleomisin · intravenöz (86) · bleomisin · intratümöral (30) · bleomisin (26) · bleomisin · hem intravenöz hem intratümöral (18) · kalsiyum klorür · intratümöral (11) · plazmid DNA · intratümöral (4)
Erişim yolu (137 yayın bildiriyor)perkütan (74) · yüzeyel transkutanöz (61) · açık cerrahi (2)
Görüntüleme kılavuzluğu (77 yayın bildiriyor)doğrudan görüş (55) · ultrason (17) · bilgisayarlı tomografi (10) · manyetik rezonans (6) · navigasyon sistemi (2)
Yanıt ölçütü (124 yayın bildiriyor)klinik muayene (39) · RECIST (28) · RECIST 1.1 (22) · diğer (12) · WHO ölçütleri (7)
Kombinasyon tedavisi (107 yayın bildiriyor)sistemik kemoterapi (62) · diğer kombinasyon (38) · diğer immünoterapi (13) · kontrol noktası inhibitörü (11) · cerrahi (8)
Tekrar tedavi bildiren yayın82 / 152 yayın (58 yayın bu bilgiyi bildirmiyor)
Alan şiddeti1–2500 V/cm (67 kayıt, ortanca 1000)
Uygulanan gerilim2–2000 V (18 kayıt, ortanca 730)
Darbe sayısı1–90 (93 kayıt, ortanca 8)
Darbe süresi1–300000 µs (94 kayıt, ortanca 100)
Toplamlar benzersiz hasta sayısı değildir: aynı kohort birden fazla yayında raporlanmış olabilir.
Yönteme Göre Literatür Durumu
Klinik yöntem başına yayın sayısı, klinik ve preklinik dağılım, literatür hacmi ve yayın aralığı. Sayfa girişindeki rozet yalnızca ECT kaydını özetler; yöntem ayrımının tamamı buradadır.
Elektrokemoterapi (ECT)
173yayın kaydı
113klinik yayın kaydı
18preklinik yayın kaydı
Yüksek klinik yayın hacmieşik 27/173 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 15, preklinik 0.
1996–2026
İrreversible elektroporasyon (IRE)
5yayın kaydı
0klinik yayın kaydı
4preklinik yayın kaydı
Keşifsel / düşük hacimli literatüreşik 1/5 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 0, preklinik 1.
2007–2024
Kalsiyum elektroporasyonu
12yayın kaydı
9klinik yayın kaydı
1preklinik yayın kaydı
Sınırlı klinik yayın hacmieşik 4/12 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 4, preklinik 0.
2017–2024
Gen elektrotransferi
4yayın kaydı
1klinik yayın kaydı
1preklinik yayın kaydı
Keşifsel / düşük hacimli literatüreşik 1/4 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 1, preklinik 0.
2009–2025
Diğer elektroporasyon uygulamaları
13yayın kaydı
2klinik yayın kaydı
5preklinik yayın kaydı
Bu küme tek bir klinik yöntemi adlandırmaz; literatür hacmi atanmaz.
2004–2025
Yöntemi belirlenmemiş kayıtlar
3yayın kaydı
1klinik yayın kaydı
0preklinik yayın kaydı
Bu küme tek bir klinik yöntemi adlandırmaz; literatür hacmi atanmaz.
2019–2023
Özetlerde Anılan Mekanizmalar
Rakam, mekanizma adının geçtiği özet sayısıdır. Bir mekanizmanın anılması, o çalışmada gösterildiği anlamına gelmez.
Bleomisin Hücre İçi Birikiminin Artması 87
Reversible Membran Permeabilizasyonu 29
Sisplatin Hücre İçi Birikiminin Artması 23
Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu 18
Kas Kasılması ve Anestezi Gereksinimi 15
Elektrot Geometrisi ve Yerleşimi 14
Kalsiyum Elektroporasyonu ve ATP Tükenmesi 12
Gen Elektrotransferi (Plazmid DNA) 10
Elektrik Alan Dağılımı ve Modellemesi 9
İrreversible Por Oluşumu ve Hücre Ölümü 9
Nekroz ve Nekroptoz 8
Sistemik / Abskopal İmmün Yanıt 8
Çalışma Tipi Dağılımı
Yüzde, alanın tamamındaki payı verir.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Randomize Klinik Çalışma | 3 | %1 |
| Prospektif Klinik Çalışma | 19 | %9 |
| Klinik Çalışma | 46 | %22 |
| Retrospektif Klinik Çalışma | 7 | %3 |
| Vaka Serisi | 6 | %3 |
| Vaka Raporu | 45 | %21 |
| Sistematik Derleme / Meta-Analiz | 11 | %5 |
| Kılavuz / Uzlaşı | 2 | <%1 |
| Derleme | 26 | %12 |
| Hayvan Çalışması | 22 | %10 |
| İn Vitro Çalışma | 4 | %2 |
| İn Siliko / Modelleme | 3 | %1 |
| Teknik / Cihaz Çalışması | 4 | %2 |
| Tez | 1 | <%1 |
| Kongre Özeti | 1 | <%1 |
| Editöryal / Mektup | 3 | %1 |
| Düzeltme / Erratum | 1 | <%1 |
| Belirtilmemiş | 3 | %1 |
| Protokol | 3 | %1 |
Yayın Tablosu
210 yayın kaydı, çalışma tasarımına göre sıralanmıştır. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
Sınıflandırmalar otomatik üretilir ve tekil kayıtlarda hata içerebilir. Metodoloji
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Hasta / lezyon | Cihaz | Ajan ve yol | Bildirilen sonuç | Özet |
|---|---|---|---|---|---|---|---|---|---|---|
| ECT | Clover et al · Eur J Surg Oncol | 2020 | Randomize Klinik Çalışma | İnsan | – | 52 / 65 | Cliniporator | bleomisin · intratümöral | tam yanıt 100% (65 lezyon) | Basal cell carcinoma (BCC) are the commonest cutaneous malignancy and incidence continues to increase. There is a need to expand the therapeutic toolbox to increase options for patients that… |
| Kalsiyum EP | Ágoston et al · Cancers (Basel) | 2020 | Randomize Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | 7 / 33 | Cliniporator | kalsiyum klorür · intratümöral | nesnel yanıt 33% (18 lezyon) | Calcium electroporation (Ca-EP) is a new anticancer treatment providing similar features to electrochemotherapy (ECT). The aim of our study is to compare the efficacy of Ca-EP with bleomycin… |
| Kalsiyum EP | Falk et al · Acta Oncol | 2017 | Randomize Klinik Çalışma | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | 7 / 37 | Cliniporator | kalsiyum klorür · intratümöral | – | Background: Calcium electroporation is a novel anticancer treatment, which utilizes high voltage pulses to permeabilize cell membranes and expose the cell to supraphysiological doses of calc… |
| ECT | Heidari et al · – | 2025 | Prospektif Klinik Çalışma | İnsan | – | 70 / 70 | OncoPore | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 94.2% (70 hasta) | Background Electrochemotherapy (ECT), a nonthermal locoregional modality, has emerged as a promising alternative for management of basal and squamous cell carcinoma (BCC & SCC) in head a… |
| ECT | Rózsa et al · Sci Rep | 2025 | Prospektif Klinik Çalışma | İnsan | – | – / 2482 | Cliniporator | bleomisin · intravenöz | – | The rising prevalence of cutaneous and subcutaneous tumors has driven interest in electrochemotherapy (ECT) as a potential treatment. However, patient-reported outcomes remain underexplored.… |
| Gen ET | Strojan et al · Eur J Surg Oncol | 2025 | Prospektif Klinik Çalışma | İnsan | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | 9 / 9 | Cliniporator | plazmid DNA · intratümöral | tümör hacmi değişimi -24% (9 hasta) | Introduction: In the treatment of cancer, immunomodulatory approaches are developed to support the organism in fighting cancer or to enhance the immunomodulatory effects of local ablative te… |
| ECT | Rózsa et al · – | 2025 | Prospektif Klinik Çalışma | İnsan | – | 62 | Cliniporator | bleomisin · intravenöz | – | Background The rising prevalence of cutaneous and subcutaneous tumors has driven interest in electrochemotherapy (ECT) as a potential treatment. However, patient-reported outcomes remain und… |
| Kalsiyum EP | Vissing et al · Eur J Surg Oncol | 2023 | Prospektif Klinik Çalışma | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Darbe Parametrelerinin Optimizasyonu | 19 / 58 | Cliniporator | kalsiyum klorür · intratümöral | – | Background: Cutaneous metastases can cause distressing symptoms and be challenging to treat. Local therapies are essential in management. Calcium electroporation uses calcium and electrical … |
| ECT | Benedik et al · Front Oncol | 2022 | Prospektif Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 27 / 113 | Cliniporator | bleomisin · intravenöz | tam yanıt 78.1% (73 lezyon) | Background: Electrochemotherapy of cutaneous tumor nodules requires local or general anesthesia. For multiple and larger nodules, general anesthesia is recommended by standard operating proc… |
| ECT | Bertino et al · Curr Oncol | 2022 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | 330 / 623 | – | bleomisin · intravenöz | tam yanıt 81% (300 hasta) | This prospective registry-based study aims to describe electrochemotherapy (ECT) modalities in basal cell carcinoma (BCC) patients and evaluate its efficacy, safety, and predictive factors. … |
| ECT | Campana et al · J Eur Acad Dermatol Venereol | 2022 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 378 | – | bleomisin · hem intravenöz hem intratümöral | tam yanıt 47% (378 hasta) | Background: Electrochemotherapy (ECT) effectively controls skin metastases from cutaneous melanoma. Objectives: This study aimed to evaluate health-related quality of life (HRQoL) in melanom… |
| ECT | Claussen et al · J Dtsch Dermatol Ges | 2022 | Prospektif Klinik Çalışma | İnsan | – | 716 / 1784 | IGEA square-wave electroporator | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 79% (302 hasta) | Background: Electrochemotherapy (ECT) is an effective local treatment for cutaneous tumors. The aim of this study was to compare the effectiveness of ECT in ulcerated vs. non-ulcerated tumor… |
| ECT | Claussen et al · J Dtsch Dermatol Ges | 2022 | Prospektif Klinik Çalışma | İnsan | – | – / 1784 | IGEA rectangular wave electroporator | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 83% (716 hasta) | Hintergrund: Elektrochemotherapie (ECT) ist eine wirksame lokale Behandlung von Hauttumoren. Ziel dieser Studie war es, die Wirksamkeit der ECT bei ulzerierten gegenüber nichtulzerierten Tum… |
| ECT | Clover et al · Eur J Cancer | 2020 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 987 / 2482 | Cliniporator | bleomisin · intravenöz | tam yanıt 70% (2482 lezyon) | Background: Electrochemotherapy (ECT) is a treatment for both primary and secondary cutaneous tumours. The international Network for sharing practices on ECT group investigates treatment out… |
| ECT | De Giorgi et al · Dermatol Ther | 2020 | Prospektif Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Bleomisin Hücre İçi Birikiminin Artması | 8 / 18 | Cliniporator, EPS02 | sisplatin · intratümöral | tam yanıt 50% (8 hasta) | Electrochemotherapy (ECT) is a well-known nonconventional skin cancer ablative method that was shown to be safe and effective for treating both locoregional disease spreading and disseminate… |
| ECT | Mascherini et al · European Journal of Surgical Oncology | 2020 | Prospektif Klinik Çalışma | İnsan | – | 1 / 1 | – | bleomisin | – | Melanoma patients with Breslow thickness greater than 4mm (AJCC 8th edition T4) have a 20-70% risk of metastases depending on histological features and nodal status. T4 melanoma patients tre… |
| ECT | Clover et al · European Journal of Surgical Oncology | 2019 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 691 / 1478 | – | bleomisin · hem intravenöz hem intratümöral | – | Electrochemotherapy is a treatment for cutaneous tumors, both primary and secondary metastatic tumors. The international Network for sharing practices on Electrochemotherapy (INSPECT) group … |
| ECT | Groselj et al · Head Neck | 2017 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 28 / 52 | Cliniporator | bleomisin · intravenöz | tam yanıt 100% (24 lezyon) | Background: In the present study, effectiveness of electrochemotherapy was compared in patients with nonmelanoma skin cancer (NMSC) of the head and neck using standard and reduced doses of b… |
| ECT | Rotunno et al · G Ital Dermatol Venereol | 2016 | Prospektif Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 9 / 14 | Cliniporator | bleomisin · intravenöz | tam yanıt 28.5714% (14 lezyon) | Background: The main purposes of this study were to evaluate the efficacy of electrochemotherapy in head and neck tumors, to assess local tumor control, its safety profile and its impact on … |
| ECT | Marty et al · European Journal of Cancer Supplements | 2006 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 41 / 171 | – | – · hem intravenöz hem intratümöral | nesnel yanıt 84.8% (171 lezyon) | Electrochemotherapy is an efficient local tumour ablation modality that has already proven its effectiveness clinically in the treatment of various types of tumours. It uses electroporation,… |
| ECT | Rodríguez-Cuevas et al · Arch Med Res | 2001 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | 15 / 38 | – | bleomisin · intratümöral | tam yanıt 49% (38 lezyon) | Background: Surgery and/or radiotherapy are the elective therapies for most primary skin cancers. Nevertheless, some patients develop recurrences, and chemotherapy has resulted in poor compl… |
| ECT | R Heller, M Jaroszeski, L Glass, J Messina, D Rapaport, R DeConti · Cancer | 1996 | Prospektif Klinik Çalışma | İnsan | – | – | – | bleomisin · intravenöz | – | Bu yayında özet bulunmuyor. |
| ECT | Covarelli et al · Ann Ital Chir | 2025 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | 97 | Cliniporator | bleomisin · intravenöz | genel sağkalım 70.45% (44 hasta) | Aim: Electrochemotherapy (ECT) combines chemotherapy with an electric pulse to directly target tumor cells by increasing cell membrane permeability, facilitating the efficient uptake of chem… |
| ECT | Eisele · J Oncol Res Ther | 2025 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 7 | SENNEX, four prong applicator | bleomisin · intratümöral | tam yanıt 60% (5 hasta) | Background: Basal cell carcinoma (BCC) is the most prevalent skin tumor worldwide.Electrochemotherapy (ECT) as an interventional treatment for BCC has been shown to be effective and is regar… |
| ECT | Koračin et al · EJC Skin Cancer | 2025 | Klinik Çalışma | İnsan | – | 3 / 43 | – | bleomisin · intravenöz | tam yanıt 2 adet (3 hasta) | Bu yayında özet bulunmuyor. |
| Kalsiyum EP | Wiegell et al · Acta Derm Venereol | 2024 | Klinik Çalışma | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi | 22 / 22 | ePORE | kalsiyum klorür · intratümöral | tam yanıt 32% (22 hasta) | In electrochemotherapy, permeabilization of the cell membrane by electric pulses increases the anti-tumour effect of chemotherapeutics. In calcium electroporation, chemotherapy is replaced b… |
| ECT | Bonadies et al · Il Giornale di Chirurgia - Journal of the Italian Association of Hospital Surgeons | 2023 | Klinik Çalışma | İnsan | – | 35 | Cliniporator | bleomisin · intravenöz | – | Background: During the COVID-19 pandemic, most of the surgical units involved in the treatment of skin cancers could continue their activities, but the reevaluation of cases and the adaptati… |
| ECT | Lyons et al · Cancers (Basel) | 2023 | Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 25 | ePORE, CUTIS probes | bleomisin · hem intravenöz hem intratümöral | – | High-frequency electroporation (HF-EP) with chemotherapy is a novel therapy proposed for both curative and palliative treatment of cutaneous malignancies. The use of high-frequency biphasic … |
| ECT | Salence et al · British Journal of Dermatology | 2023 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 71 / 89 | – | bleomisin | tam yanıt 11 adet (19 hasta) | Electrochemotherapy (ECT) has gained recognition as an effective treatment that uses electrical pulses to permeabilize cell membranes in tumours, enhancing the cytotoxicity of anticancer age… |
| Kalsiyum EP | Vestergaard · Cancers (Basel) | 2023 | Klinik Çalışma | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – | – | kalsiyum klorür · intratümöral | – | (1) Background: Calcium electroporation is a novel cancer treatment. It includes injecting calcium-solution and applying electric pulses to tumour tissue. Data on quality of life for patient… |
| ECT | Bertino et al · Front Oncol | 2022 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 162 / 342 | Cliniporator | bleomisin · hem intravenöz hem intratümöral | tam yanıt 62% (162 hasta) | Introduction: Cutaneous squamous cell carcinoma (cSCC) is a frequent skin cancer with a high risk of recurrence characterized by tumor infiltration and, in advanced cases, a poor prognosis. … |
| ECT | Mascherini et al · European Journal of Surgical Oncology | 2022 | Klinik Çalışma | İnsan | – | 39 | Cliniporator VITAE, Cliniporator | bleomisin | nesnel yanıt 91% | Bu yayında özet bulunmuyor. |
| Kalsiyum EP | Pervan et al · Annals of Oncology | 2022 | Klinik Çalışma | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – | – | kalsiyum klorür · intratümöral | – | Bu yayında özet bulunmuyor. |
| Kalsiyum EP | Falk et al · Dermatology | 2021 | Klinik Çalışma | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi | 6 / 6 | Cliniporator | kalsiyum klorür · intratümöral | kısmi yanıt 33% (6 hasta) | Background: Keloid scarring is a pathologic proliferation of scar tissue that often causes pruritus, pain, and disfigurement. Keloids can be difficult to treat and have a high risk of recurr… |
| ECT | Lyons et al · JPRAS Open | 2021 | Klinik Çalışma | İnsan | – | 25 | – | bleomisin | – | Introduction: The establishment and success of new treatments are significantly influenced by patient satisfaction. Post-operative scarring is an important outcome for patients, and subseque… |
| ECT | Sersa et al · Eur J Surg Oncol | 2021 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | 183 | – | bleomisin | – | Background: With extending life expectancy, more people are diagnosed with cutaneous malignancies at advanced ages and are offered nonsurgical treatment. We assessed outcomes of the oldest-o… |
| ECT | Bartolo et al · Dermatol Ther | 2020 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 5 | Cliniporator | bleomisin · intravenöz | tam yanıt 4 adet (5 hasta) | Epidermolysis Bullosa (EB) is a rare group of diseases caused by genetic variants in skin structural proteins. EB is characterized by varying degrees of skin fragility, blisters and impaired… |
| Diğer EP | Bhatia et al · Clin Cancer Res | 2020 | Klinik Çalışma | İnsan | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | 15 / 27 | – | plazmid DNA · intratümöral | – | Purpose: IL12 promotes adaptive type I immunity and has demonstrated antitumor efficacy, but systemic administration leads to severe adverse events (AE), including death. This pilot trial in… |
| ECT | Campana et al · Int J Surg | 2019 | Klinik Çalışma | İnsan | Hemostaz ve Kanama Kontrolü | 20 / 51 | Cliniporator, EPS-01, EPS-02 | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 80% (20 hasta) | Background: Cutaneous angiosarcoma (cAS) is a highly aggressive malignancy that challenges the radicality of surgical treatment. Electrochemotherapy (ECT), a skin-directed treatment based on… |
| ECT | Kis et al · Sci Rep | 2019 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 12 | Cliniporator | bleomisin · hem intravenöz hem intratümöral | tam yanıt 100% (12 hasta) | There is increasing evidence about the effectiveness of electrochemotherapy (ECT) in the treatment of basal cell carcinomas in the head and neck region, although its role in the management o… |
| ECT | Padilla-España et al · Actas Dermo-Sifiliográficas (English Edition) | 2019 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 1 | Cliniporator | bleomisin · intravenöz | – | Electrochemotherapy (ECT) is a therapeutic procedure that combines the phenomenon of electroporation of the cell membrane with the administration of a chemotherapy drug, generally bleomycin … |
| Belirlenmedi | Padilla-España et al · Actas Dermosifiliogr (Engl Ed) | 2019 | Klinik Çalışma | İnsan | – | 1 | Cliniporator | bleomisin · intravenöz | – | Bu yayında özet bulunmuyor. |
| ECT | Gargiulo et al · J Craniomaxillofac Surg | 2018 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 21 | Cliniporator | bleomisin · intravenöz | nesnel yanıt 100% (21 hasta) | Purpose: Electrochemotherapy (ECT) is a therapeutic approach based on the local application of electrical pulses that permeabilize cell membranes to enhance the uptake of low-permeant chemot… |
| ECT | Rotunno et al · G Ital Dermatol Venereol | 2018 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 81 | Cliniporator | bleomisin · intravenöz | hastalıksız sağkalım 3 ay (81 hasta) | Background: The management of non-melanoma skin cancers may benefit from alternative treatments and in this spectrum electrochemotherapy plays a pivotal role. The aim was to describe the pre… |
| ECT | Campana et al · J Transl Med | 2017 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 84 / 185 | – | bleomisin · hem intravenöz hem intratümöral | tam yanıt 50% (84 hasta) | Background: Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy. The accumulated evidence… |
| ECT | Rotunno et al · J Eur Acad Dermatol Venereol | 2017 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 57 / 147 | Cliniporator | bleomisin · intravenöz | tam yanıt 70.1% (147 lezyon) | Background: Electrochemotherapy (ECT) is currently used to treat unresectable superficial tumours of different histotypes through the combination of cytotoxic chemotherapy and local applicat… |
| ECT | Anon · Plastic and Reconstructive Surgery - Global Open | 2016 | Klinik Çalışma | İnsan | – | 86 / 105 | – | – | genel sağkalım 100% (86 hasta) | Ruth Tevlin, MB, BAO, BCh, MRCSI,* S. Salwa, MD,* J. Mc Kiernan, MD,* Christina Buckley, MB, BAO, BCh, MRCSI,* M. Bourke, MD,* E.J. Kelly, MB, BCh, BAO, MD, FRCSI, FRCS (Plast),* S.T. O’Sull… |
| ECT | Campana et al · Radiol Oncol | 2016 | Klinik Çalışma | İnsan | Elektrot Geometrisi ve Yerleşimi | – | Igea S.p.A. pulse generator | bleomisin | – | Background: In recent years, superficial chest wall recurrence from breast cancer can be effectively treated by means of electrochemotherapy, with the majority of patients achieving response… |
| ECT | Campana et al · Eur J Surg Oncol | 2016 | Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 376 / 1304 | Cliniporator | – · intravenöz | tam yanıt 50% (376 hasta) | Background: Cutaneous metastases represent a therapeutic challenge. An increasing body of experience suggests that electrochemotherapy (ECT) provides effective tumor control, although its ev… |
| ECT | Wichtowski et al · European Journal of Surgical Oncology (EJSO) | 2016 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu | 17 / 95 | – | bleomisin · intravenöz | tam yanıt 57.9% (19 seans) | Background: Electrochemotherapy (ECT) is a ablation method based on reversible electroporation combination with concurrent chemotherapy (intravenous administration or into the tumor). This m… |
| ECT | Allegra et al · Drug Des Devel Ther | 2015 | Klinik Çalışma | İnsan | – | 4 / 4 | Cliniporator | bleomisin · intravenöz | tümör hacmi değişimi 75% (4 hasta) | Introduction: Electrochemotherapy (ECT) is a new therapeutic method that is used in oncology as palliative treatment in patients with recurrent head and neck tumors and who are not candidate… |
| ECT | Salwa et al · J Plast Reconstr Aesthet Surg | 2014 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | 3 / 3 | Cliniporator | bleomisin · intratümöral | tam yanıt 100% (3 lezyon) | Basal Cell Carcinoma (BCC) affecting the ocular region is potentially problematic due to its ability to infiltrate aesthetic and functional structures. Due to the paucity of local tissue, re… |
| ECT | Manca et al · Plast Reconstr Surg | 2013 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 20 / 35 | Cliniporator | bleomisin · intratümöral | tam yanıt 9% (35 lezyon) | Background: Keloids and hypertrophic scars are the result of abnormal healing responses and dermal tissue proliferation; current surgical procedures can give rise to exuberant scarring and p… |
| ECT | Solari et al · J Surg Oncol | 2013 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 39 | IGEA square wave electroporator | bleomisin · intravenöz | – | Background and objectives: Electrochemotherapy (ECT) is technique for local control of skin metastasis. This study is primarily aimed at assessing the clinical activity of ECT in a prospecti… |
| ECT | Rossi et al · European Journal of Surgical Oncology (EJSO) | 2012 | Klinik Çalışma | İnsan | Sistemik / Abskopal İmmün Yanıt | 22 | Cliniporator | bleomisin · intravenöz | ağrı yanıtı 0 cm³ (22 hasta) | Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas of the head and neck. Local recurrence is frequent, lymph nodal metastasis are rare, but distant metastase… |
| ECT | Solari et al · European Journal of Surgical Oncology (EJSO) | 2012 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 37 / 666 | – | bleomisin · intravenöz | tam yanıt 40% (15 hasta) | Electrochemotherapy (ECT), a new palliative treatment for cutaneous metastases, involves the delivery of electrical pulses to lesions several minutes after intravenous or intratumor injectio… |
| ECT | Matthiessen et al · Acta Oncol | 2011 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 52 / 97 | Cliniporator | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 86% (84 lezyon) | Background: Cutaneous metastases may cause considerable discomfort as a consequence of ulceration, oozing, bleeding and pain. Electrochemotherapy has proven to be highly effective in the tre… |
| ECT | Kis et al · Orv Hetil | 2010 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | 7 / 81 | – | bleomisin · intravenöz | tam yanıt 25% (81 lezyon) | Unlabelled: Electrochemotherapy is an effective treatment of cutaneous and subcutaneous metastases in patients with malignant melanoma. During the treatment, electric pulses are applied to t… |
| Diğer EP | Landström et al · Dermatol Surg | 2010 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 6 / 6 | MedPulser | bleomisin · intratümöral | tam yanıt 4 adet (6 hasta) | Background: Electroporation therapy is a new cancer treatment modality in which a locally applied electrical field enhances cell membrane permeability, allowing greater intracellular accumul… |
| ECT | Quaglino et al · European Journal of Cancer Supplements | 2009 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 36 / 936 | – | bleomisin · intravenöz | – | Electrochemotherapy (ECT) is an emerging treatment modality for cutaneous and subcutaneous metastases from different tumour types; it combines electroporation with injection of a chemotherap… |
| ECT | Sainsbury et al · European Journal of Cancer Supplements | 2009 | Klinik Çalışma | İnsan | – | 18 / 133 | – | bleomisin · intravenöz | tam yanıt 33.3% (18 hasta) | Although more than 90% of melanomas have a cutaneous origin, occasionally it is discovered fist as a secondary deposit without evident primary site. The aim of this study was to systematicall… |
| ECT | Mali et al · Med Biol Eng Comput | 2008 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 14 | Cliniporator | bleomisin · intratümöral | – | Electrochemotherapy is an effective antitumor treatment currently applied to cutaneous and subcutaneous tumors. Electrochemotherapy of tumors located close to the heart could lead to adverse… |
| ECT | Peycheva et al · Bioelectrochemistry | 2007 | Klinik Çalışma | İnsan | – | 8 / 29 | – | diğer · intratümöral | tam yanıt 86.2% (29 lezyon) | Eight patients with 29 lesions of histologically verified 1st stage of Mycosis fungoides were successfully treated by electrochemotherapy with interferon-alpha. For this purpose 8 biphasic p… |
| ECT | Muñoz Madero et al · European Journal of Surgical Oncology (EJSO) | 2006 | Klinik Çalışma | İnsan | – | 15 / 75 | – | bleomisin · intravenöz | tam yanıt 6 adet (15 hasta) | Electrochemotherapy is an unexpensive and effective therapy for local control of cancer. In our experience, it has shown to be effective against a variety of cancer types. In developing coun… |
| ECT | R Heller, M Jaroszeski, D Reintgen, C Puleo, R DeConti, R Gilbert · Cancer | 1998 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 34 / 143 | BTX T820 Electro Square Porator | bleomisin · intratümöral | nesnel yanıt 99.3% (143 lezyon) | Electrochemotherapy (ECT) is performed by locally administering a chemotherapeutic agent in combination with electric pulses. Previous clinical studies have demonstrated the effectiveness of… |
| ECT | Mir et al · Br J Cancer | 1998 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 50 / 291 | PS 15 | bleomisin · intravenöz | tam yanıt 56.4% (273 lezyon) | Electrochemotherapy (ECT) enhances the effectiveness of chemotherapeutic agents by administering the drug in combination with short intense electric pulses. ECT is effective because electric… |
| ECT | Glass et al · J Am Acad Dermatol | 1997 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – | BTX T820 pulse generator | bleomisin | – | Background: A new anticancer therapy, electrochemotherapy (ECT), has been introduced that entails exposing cancerous tissues to short pulses of electricity during chemotherapy. This enhances… |
| ECT | Glass et al · J Am Acad Dermatol | 1996 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – | T820 | – | – | Background: A new technique, electroporation, enhances the antitumor effects of a variety of chemotherapeutic agents. When used in combination with conventional chemotherapy, the procedure i… |
| ECT | Grošelj et al · Sci Rep | 2025 | Retrospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 116 / 257 | Cliniporator | bleomisin · intravenöz | – | Electrochemotherapy (ECT) is a minimally invasive treatment option for basal cell carcinoma (BCC), which is particularly advantageous in the elderly population. This study evaluated the long… |
| ECT | Canala · – | 2024 | Retrospektif Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması | 7 / 13 | – | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 9 adet (13 lezyon) | Bu yayında özet bulunmuyor. |
| ECT | Iezzi et al · Life (Basel) | 2023 | Retrospektif Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 5 / 5 | Cliniporator | bleomisin · intravenöz | tam yanıt 4 adet (5 hasta) | Interventional Oncology treatments grant low-risk mini-invasive alternatives to surgery for cancer patients. Percutaneous ablative therapies represent a cornerstone for treatment of liver ca… |
| ECT | Bertino et al · European Journal of Surgical Oncology | 2019 | Retrospektif Klinik Çalışma | İnsan | – | 246 / 466 | – | bleomisin | nesnel yanıt 93.8% (240 hasta) | Despite a well-organized Hungarian national invitational breast screening that is free of charge, the participation rate has never reached 70%. This study assessed the socioeconomic factors … |
| ECT | Di Monta et al · J Transl Med | 2017 | Retrospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | 376 | Cliniporator, N-20-4B linear needle electrodes, N-20 HG needle electrodes | bleomisin · intravenöz | nesnel yanıt 81.8% (22 hasta) | Background: Extensive squamous cell carcinoma has few therapeutic options. In such cases, electrochemotherapy involving electroporation combined with antineoplastic drug appears to be a new … |
| ECT | Guida et al · J Surg Oncol | 2016 | Retrospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Antivasküler Etki ve Damar Yıkımı | 19 / 54 | – | bleomisin · intravenöz | nesnel yanıt 63% (19 hasta) | Background: Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxi… |
| ECT | Kreuter et al · J Dtsch Dermatol Ges | 2015 | Retrospektif Klinik Çalışma | İnsan | – | 56 | Cliniporator, SENNEX | bleomisin · intravenöz | – | Background and objectives: Once classic treatments such as chemotherapy or radiation therapy have been exhausted, only few therapeutic options remain for extensive skin tumors or cutaneous m… |
| ECT | Groselj et al · Radiol Oncol | 2025 | Vaka Serisi | İnsan | – | 132 / 158 | Cliniporator | bleomisin | tam yanıt 96% (132 hasta) | Background: Basal cell carcinoma (BCC) is a cutaneous malignancy that typically appears in sun-exposed areas. We analyzed data from the Insp-ECT registry of all patients affected by BCC in t… |
| ECT | Vass et al · Int J Dermatol | 2025 | Vaka Serisi | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 19 | – | bleomisin · intratümöral | tam yanıt 95% (19 hasta) | Background: While electrochemotherapy (ECT) is increasingly utilized as a highly effective method in the treatment of tumors in the head and neck region, there is significantly less data ava… |
| Kalsiyum EP | Ahmed-Salim et al · EJGO | 2021 | Vaka Serisi | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Nekroz ve Nekroptoz | 5 | CUTIS, ePORE | kalsiyum klorür · intratümöral | tam yanıt 5 skor (10 seans) | Objective: Calcium electroporation (CaEP) is a new technique whereby intracellular concentrations of calcium are elevated by transient permeabilisation of the cell membrane using high-voltag… |
| ECT | Kristiansson et al · Acta Otolaryngol | 2019 | Vaka Serisi | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 7 / 7 | MedPulser, Cliniporator | bleomisin · intratümöral | tam yanıt 5 adet (7 hasta) | Background: Electrochemotherapy (ECT) is a cancer treatment modality where the intracellular accumulation of chemotherapeutic agents is enhanced by an applied electrical field. Aims/objectiv… |
| ECT | Ullrich et al · Ophthalmic Plast Reconstr Surg | 2019 | Vaka Serisi | İnsan | – | 4 | – | bleomisin · intravenöz | – | Electrochemotherapy has been used successfully for treatment of recurrent head and neck skin cancers and skin metastasis. It combines both electroporation and chemotherapy. The authors repor… |
| ECT | Kendler et al · Dermatol Surg | 2013 | Vaka Serisi | İnsan | Kas Kasılması ve Anestezi Gereksinimi, Bleomisin Hücre İçi Birikiminin Artması | 4 / 80 | Cliniporator | bleomisin · intratümöral | nesnel yanıt 2 adet (10 lezyon) | Background: The surgical management of cutaneous metastasis (CM) is challenging, particularly in elderly patients, in whom general anesthesia can be difficult because of comorbidity. Objecti… |
| ECT | Nicolai et al · Int Med Case Rep J | 2026 | Vaka Raporu | İnsan | Nekroz ve Nekroptoz | 1 / 1 | Cliniporator VITAE | bleomisin · intratümöral | tam yanıt 1 adet (1 hasta) | Background: Squamous cell carcinoma is a malignant tumor that affects the skin and mucous membranes. It may present as painless superficial lesions, or as rapidly growing, exophytic masses, … |
| ECT | Nicolai et al · J Med Case Rep | 2026 | Vaka Raporu | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 1 / 1 | Cliniporator VITAE | bleomisin · intratümöral | tam yanıt 1 adet (1 hasta) | Background: Skin areas chronically exposed to solar radiation, such as the face, neck, scalp, and upper limbs, are at significantly increased risk of developing basal cell carcinoma. The obj… |
| ECT | Nicolai et al · Clin Case Rep | 2026 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 / 22 | Cliniporator VITAE | bleomisin · intratümöral | tam yanıt 1 adet (1 hasta) | Cutaneous squamous cell carcinoma (cSCC) is a malignant epithelial tumor of the skin, classified as a nonmelanoma skin cancer. It may develop from precancerous conditions such as chronic inf… |
| ECT | de Moraes-Souza et al · Actas Dermosifiliogr | 2026 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 13 | – | bleomisin · hem intravenöz hem intratümöral | tam yanıt 2 adet (13 hasta) | , Electrochemotherapy (ECT) is a localized and targeted form of chemotherapy used to treat various types of primary and secondary cutaneous tumors.1,2 This technique combines the administrat… |
| ECT | Peña et al · Animals (Basel) | 2025 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | Onkodisruptor, ElectroVet EZ | – | – | Captive birds of prey often exceed their wild counterparts' lifespan, as seen in bald eagles ( Haliaeetus leucocephalus , ~20 years wild vs. ~40 years captive), golden eagles ( Aquila chrysa… |
| ECT | Russano et al · J Pers Med | 2024 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu | 1 / 1 | – | bleomisin · intravenöz | tam yanıt 0 gün (1 hasta) | Background: Basal cell carcinomas (BCCs) are common human malignancies with a rising incidence in recent years. While BCCs have a low mortality rate, they are often associated with significa… |
| ECT | Schmelter et al · J Dtsch Dermatol Ges | 2022 | Vaka Raporu | İnsan | – | 4 / 4 | Cliniporator | bleomisin · intravenöz | tam yanıt 4 adet (4 hasta) | Bu yayında özet bulunmuyor. |
| ECT | Gambichler et al · J Eur Acad Dermatol Venereol | 2021 | Vaka Raporu | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Bleomisin Hücre İçi Birikiminin Artması | 1 | – | bleomisin | genel sağkalım 0 gün (1 hasta) | Hydroxyurea and ruxolitinib are frequently used to treat myeloproliferative disorders, including polycythaemia vera, and chronic treatment is associated with many cutaneous adverse effects s… |
| ECT | Landström et al · Anticancer Res | 2021 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 2 | MedPulser, Cliniporator | bleomisin · intratümöral | – | Background/aim: Electrochemotherapy (ECT) is a predominately palliative treatment for cutaneous metastases where an electric field is used to increase the intracellular accumulation of a che… |
| ECT | Mastrandrea et al · Medicine (Baltimore) | 2021 | Vaka Raporu | İnsan | – | 1 / 1 | Cliniporator VITAE | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Rationale: According to scientific literature, cryoablation (CA) and electrochemotherapy (ECT) have been used for the treatment of small renal masses. However, no data have been published re… |
| Kalsiyum EP | Stranzenbach et al · J Dtsch Dermatol Ges | 2021 | Vaka Raporu | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi | 1 / 2 | ePORE | kalsiyum klorür · intratümöral | tam yanıt 1 adet (1 hasta) | Bu yayında özet bulunmuyor. |
| ECT | Torchio et al · Front Oncol | 2021 | Vaka Raporu | İnsan | Sistemik / Abskopal İmmün Yanıt | 1 / 1 | Cliniporator | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | This case report shows, for the first time, a patient experiencing a complete response after one dose of avelumab following extensive disease progression with prior electrochemotherapy (ECT)… |
| ECT | Cavaco et al · Eur Thyroid J | 2020 | Vaka Raporu | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Cliniporator | bleomisin · intravenöz | – | Advanced papillary thyroid carcinoma (PTC) with cutaneous metastases may cause pain, ulceration, and bleeding. Electrochemotherapy (ECT) is a minimally invasive treatment of tumors located i… |
| ECT | Fabrizio et al · J Plast Reconstr Aesthet Surg | 2020 | Vaka Raporu | İnsan | Nekroz ve Nekroptoz, Kas Kasılması ve Anestezi Gereksinimi | 41 | Cliniporator | bleomisin · intravenöz | tam yanıt 61% (41 hasta) | Electrochemotherapy (ECT) is a local treatment and its use has been standardised for cutaneous nodules of any histological origin. In this study, we use ECT as a neoadjuvant therapy to reduc… |
| ECT | Pichi et al · Anticancer Drugs | 2020 | Vaka Raporu | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 1 / 1 | Cliniporator VITAE | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Cutaneous squamous cell carcinoma of the head and neck district are generally treated with surgery. Surgery is the standard treatment in early stages and local advanced tumors, followed by a… |
| ECT | Crimini et al · Case Rep Oncol Med | 2019 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu | 1 / 1 | Cliniporator, adjustable linear needle electrode | bleomisin · intravenöz | tam yanıt 100% (1 lezyon) | Background Atypical fibroxanthoma (AFX) is a tumor that commonly presents on the head or neck in older individuals. Making a definitive diagnosis of AFX is challenging, and frequently, it is… |
| ECT | Lanza et al · Open Vet J | 2019 | Vaka Raporu | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | Onkodisruptor | bleomisin · intratümöral | hastalıksız sağkalım 12 ay (1 hayvan) | Background: Cutaneous tumors are rarely described in avian and are frequently of viral origin. Solid tumors of vascular origin are seldom reported and usually result in difficult management … |
| ECT | Racnik et al · N Z Vet J | 2019 | Vaka Raporu | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | – / 1 | Cliniporator | sisplatin · intratümöral | tümör hacmi değişimi 7 gün (1 lezyon) | Fibromas are uncommon benign neoplasms in birds; they originate in fibrous connective tissue and can be found almost everywhere, most frequently on the head, face, beak and cere, legs, wings… |
| ECT | Pasquali et al · Dermatol Ther (Heidelb) | 2018 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 / 1 | Onkodisruptor | bleomisin · intratümöral | tam yanıt 1 adet (1 hasta) | Introduction: Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that e… |
| ECT | Baltás et al · Acta Derm Venereol | 2017 | Vaka Raporu | İnsan | – | 1 / 34 | Cliniporator | bleomisin · intravenöz | tam yanıt 97% (33 lezyon) | An 11-year-old girl with XP was referred to our dermato-oncology centre with advanced non-melanoma skin cancers (NMSCs) on her face. Xerosis, skin atrophy, freckling and numerous scars from … |
| ECT | Guida et al · Br J Dermatol | 2017 | Vaka Raporu | İnsan | – | 1 / 1 | – | – | tam yanıt 100% (1 lezyon) | Funding sources: S.S. is supported by a grant from the ‘Maria Ruggieri No Profit Association for research on angiosarcoma and rare tumors’. Conflicts of interest: none declared. Dear Editor,… |
| ECT | Sponghini et al · Anticancer Drugs | 2017 | Vaka Raporu | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 1 / 1 | – | bleomisin · intravenöz | – | The advent of immune checkpoint inhibitors anti-PD-1/PD-L1 has delivered new and effective treatment options with proven clinical benefits for patients affected by metastatic melanoma. The 3… |
| ECT | Spugnini et al · Open Vet J | 2017 | Vaka Raporu | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | Onkodisruptor | bleomisin · intravenöz | tam yanıt 1 adet (1 hayvan) | A twenty-year-old female saddle horse was referred for evaluation of a seven month, non-healing erosive lesion of the right hind hoof with proliferation and bleeding of the underlying soft t… |
| ECT | Campana et al · J Vasc Interv Radiol | 2016 | Vaka Raporu | İnsan | – | 1 | – | bleomisin · intravenöz | – | LETTERS TO THE EDITOR Angiosarcoma on Lymphedema (Stewart–Treves Syndrome): A 12-Year Follow-up after Isolated Limb Perfusion, Limb Infusion, and Electrochemotherapy From: Luca G. Campana, M… |
| ECT | Ribero et al · Dermatol Ther | 2016 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 / 10 | Cliniporator | bleomisin · intratümöral | nesnel yanıt 10 adet (10 lezyon) | Generalized eruptive keratoacanthoma, is considered a serious condition because the eruptions are diffuse, persistent, and recurrent. Constant pruritus, visceral neoplasms, and unsatisfactor… |
| ECT | Sommerlad et al · Br J Dermatol | 2016 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 | – | bleomisin · intravenöz | – | Porokeratosis is a clonal epidermal disorder of keratinization characterized by annular lesions with an atrophic centre and a hyperkeratotic edge. The cornoid lamella is the histopathologica… |
| ECT | Diociaiuti et al · J Eur Acad Dermatol Venereol | 2015 | Vaka Raporu | İnsan | – | 3 / 4 | – | bleomisin · intravenöz | tam yanıt 3 adet (4 lezyon) | Bu yayında özet bulunmuyor. |
| ECT | Lanza et al · J Am Vet Med Assoc | 2015 | Vaka Raporu | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – / 1 | Onkodisruptor | bleomisin · intratümöral | hastalıksız sağkalım 12 ay (1 hasta) | Case description: A 5-year-old female yellow-bellied slider (Trachemys scripta scripta) was referred for evaluation of a 2-month nonhealing ulcerated mass on the dorsal aspect of the neck. C… |
| ECT | Lido et al · An Bras Dermatol | 2015 | Vaka Raporu | İnsan | – | 1 | Cliniporator | bleomisin · intravenöz | – | We describe herein what is to our knowledge the first reported case of an invasive cutaneous metastasis with unknown primary, electively treated solely with electrochemotherapy. We describe … |
| ECT | Ruggeri et al · Melanoma Manag | 2015 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 / 3 | Cliniporator | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Basal cell carcinoma (BCC) is the most common skin cancer in Caucasian population. Surgical excision is the gold standard treatment for BCC. Secondary surgical approach in patients presentin… |
| ECT | Brunner et al · J Zoo Wildl Med | 2014 | Vaka Raporu | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – | – | – | – | Fibropapillomatosis continues to be an important cause of morbidity and mortality in sea turtles, particularly in Chelonia mydas. Turtles with this debilitating herpesvirus disease usually p… |
| ECT | Gatti et al · Dermatol Ther | 2014 | Vaka Raporu | İnsan | – | 3 | square wave electroporator | bleomisin · intravenöz | tam yanıt 3 adet (3 hasta) | In the present study, we describe the use of electrochemotherapy as alternative therapy for primary cutaneous marginal zone B-cell lymphomas in patients unsuitable for surgery or radiotherap… |
| ECT | Macri et al · Head Neck | 2014 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu | 1 / 1 | – | bleomisin · intravenöz | tam yanıt 1 oran | Background: Squamous cell carcinoma (SCC) is the most common oral cavity malignant tumor. Surgery, radiotherapy, and chemotherapy have been the major options for its treatment. Electrochemot… |
| ECT | di Meo et al · Indian J Dermatol Venereol Leprol | 2014 | Vaka Raporu | İnsan | Hemostaz ve Kanama Kontrolü | 1 / 1 | – | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | No post-operative complications such as scar contracture, graft failure or relapse of disease were encountered. With regard to hemostasis, high flow vessels greater than 500 m are likely to … |
| ECT | Campana et al · Radiol Oncol | 2013 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 1 / 1 | – | bleomisin · intravenöz | – | Background: Peristomal metastases are rare, but potentially associated with relevant morbidity. Surgical resection, followed by stoma relocation, represent the gold standard in most patients… |
| ECT | Scelsi et al · Radiol Oncol | 2013 | Vaka Raporu | İnsan | – | 1 / 1 | Cliniporator | bleomisin · intravenöz | tümör hacmi değişimi 50% (1 hasta) | Background: Merkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatme… |
| ECT | Wiater et al · Eur J Dermatol | 2013 | Vaka Raporu | İnsan | – | 1 / 1 | – | bleomisin · intravenöz | progresyonsuz sağkalım 12 ay (1 lezyon) | Bu yayında özet bulunmuyor. |
| ECT | Kis et al · Acta Derm Venereol | 2012 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 3 / 99 | Cliniporator | bleomisin · intravenöz | tam yanıt 86 adet (99 lezyon) | Gorlin-Goltz syndrome is a rare multisystemic disease, characterized by numerous basal cell carcinomas. The ideal approach for patients with the syndrome would be a treatment with a high cur… |
| ECT | Marenco et al · Eur J Dermatol | 2011 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 1 | Cliniporator | bleomisin · intravenöz | tam yanıt 4 hafta (1 hasta) | Electrochemotherapy (ECT) has recently emerged as a treatment for cutaneous and subcutaneous lesions from different malignancies, including squamous cell carcinoma (SCC), with curative or pa… |
| ECT | Marone et al · World J Surg Oncol | 2011 | Vaka Raporu | İnsan | Sistemik / Abskopal İmmün Yanıt | 1 | Cliniporator | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Eccrine porocarcinoma (EPC) is a rare type of skin cancer arising from the intraepidermal portion of eccrine sweat glands or acrosyringium, representing 0.005-0.01% of all cutaneous tumors. … |
| ECT | Richetta et al · Clin Ter | 2011 | Vaka Raporu | İnsan | – | 1 / 2 | – | bleomisin · intravenöz | – | Basal cell carcinoma is the most common cutaneous malignant tumor, accounting for up to 80% of non melanoma skin cancers. Surgery, radiotherapy and chemotherapy have been for long time the m… |
| ECT | Kaehler et al · Dermatol Surg | 2010 | Vaka Raporu | İnsan | – | 1 / 6 | MedPulser | bleomisin · intratümöral | tam yanıt 100% (6 lezyon) | Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is commi… |
| ECT | Sainsbury et al · J Plast Reconstr Aesthet Surg | 2010 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 / 1 | – | bleomisin · intratümöral | tam yanıt 1 gün (1 lezyon) | Electrochemotherapy, a tumour ablation modality, which facilitates intracellular delivery of poorly-permeable cytotoxic drugs, such as bleomycin, has shown promising results in the treatment… |
| ECT | Curatolo et al · Arch Dermatol | 2009 | Vaka Raporu | İnsan | – | 1 | – | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | [No abstract available] |
| ECT | Fantini et al · Arch Dermatol | 2008 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 / 8 | Cliniporator | bleomisin · hem intravenöz hem intratümöral | tam yanıt 2 adet (2 lezyon) | Background: Metastatic basal cell carcinoma is a rare disease with poor prognosis. Palliative therapeutic approaches include surgery, radiotherapy, and/or chemotherapy. These treatment modal… |
| ECT | Tan et al · Cancers (Basel) | 2025 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 21 | – | – | – | Background: Keratinocyte carcinomas, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), presents a growing concern. Electrochemotherapy (ECT), an emerging treatment moda… |
| ECT | Wu et al · Clin Transl Oncol | 2024 | Sistematik Derleme / Meta-Analiz | İnsan | – | – / 208 | – | bleomisin · intravenöz | tam yanıt 66.5% (162 hasta) | Objective: Treating aggressive superficial squamous cell carcinoma (SCC) poses challenges due to invasiveness. Palliative care is recommended for inoperable cases with extensive tumors near … |
| ECT | McMillan et al · PLoS One | 2023 | Sistematik Derleme / Meta-Analiz | İnsan | – | 208 / 477 | – | bleomisin · intravenöz | tümör hacmi değişimi 2 adet (3 hasta) | Background: Electrochemotherapy has gained international traction and commendation in national guidelines as an effective tool in the management of cutaneous malignancies not amenable to sur… |
| ECT | Bastrup et al · Acta Oncol | 2022 | Sistematik Derleme / Meta-Analiz | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 3729 | – | bleomisin · intravenöz | nesnel yanıt 81.5% (3729 hasta) | Background: Electrochemotherapy (ECT) is an established treatment for primary and secondary cutaneous tumours. The method combines chemotherapy with electroporation, thus increasing the cyto… |
| ECT | Hendel et al · J Eur Acad Dermatol Venereol | 2021 | Sistematik Derleme / Meta-Analiz | İnsan | Bleomisin Hücre İçi Birikiminin Artması | – / 1545 | – | bleomisin | tam yanıt 92% (65 lezyon) | Basal cell carcinoma (BCC) is the most common type of cancer and an increasing incidence stimulates the interest in new treatments such as electrochemotherapy (ECT) with bleomycin. This syst… |
| ECT | Petrelli et al · Acta Oncol | 2021 | Sistematik Derleme / Meta-Analiz | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 1161 / 5308 | – | bleomisin · hem intravenöz hem intratümöral | lokal kontrol 54% (1161 hasta) | Background: Electrochemotherapy (ECT) harnesses electric pulses to enhance cytotoxic drug delivery into tumors and has entered the armamentarium to treat superficially metastatic melanoma. W… |
| ECT | Morley et al · Eur J Surg Oncol | 2019 | Sistematik Derleme / Meta-Analiz | İnsan | – | – | – | bleomisin · intravenöz | nesnel yanıt 82.2% (1194 hasta) | Background: Electrochemotherapy combines electroporation in conjunction with chemotherapeutic agents and is used to treat tumours in many localisations, including cutaneous metastases. The s… |
| ECT | Seyed Jafari et al · Eur J Dermatol | 2018 | Sistematik Derleme / Meta-Analiz | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin | nesnel yanıt 84.02% | Electrochemotherapy is becoming a promising technique for the management of malignancies of skin and non-skin origin. The current review aims to clarify current knowledge on administration o… |
| ECT | Aguado-Romeo et al · Actas Dermo-Sifiliográficas (English Edition) | 2017 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | 39 / 4313 | – | bleomisin · intravenöz | nesnel yanıt 86.3% (60 hasta) | Electrochemotherapy is a therapeutic option for the treatment of cutaneous and subcutaneous metastases from melanoma and other tumors. The procedure consists of the administration of antican… |
| ECT | Zygogianni et al · Asian Pac J Cancer Prev | 2016 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | – | – | bleomisin · intravenöz | – | Background: The aim of this study was to investigate whether electrochemotherapy is a clinically and cost-effective treatment option against skin tumors. Materials and methods: We performed … |
| Diğer EP | Spratt et al · J Clin Oncol | 2014 | Sistematik Derleme / Meta-Analiz | İnsan | – | 915 / 4313 | – | bleomisin | nesnel yanıt 60.2% (4313 lezyon) | Purpose: To perform the first meta-analysis of the efficacy of skin-directed therapies for cutaneous metastases. Methods: MEDLINE, EMBASE, The Cochrane Library, and ClinicalTrials.gov databa… |
| Diğer EP | Peris et al · Eur J Cancer | 2023 | Kılavuz / Uzlaşı | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | – | – | – | – | Basal cell carcinoma (BCC) is the most common malignant tumour in white populations. Multidisciplinary experts from European Association of Dermato-Oncology (EADO), European Dermatology Foru… |
| Belirlenmedi | Stratigos et al · Eur J Cancer | 2023 | Kılavuz / Uzlaşı | İnsan | Sistemik / Abskopal İmmün Yanıt, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 193 | – | bleomisin | – | In order to update recommendations on treatment, supportive care, education, and follow-up of patients with invasive cutaneous squamous cell carcinoma (cSCC), a multidisciplinary panel of ex… |
| ECT | Papalexis et al · Curr Oncol | 2026 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin | – | Electrochemotherapy is a minimally invasive treatment based on the principle of reversible electroporation of target cells in pathologic tissues in order to increase the local effect of chem… |
| Diğer EP | Chan · Medicina (Kaunas) | 2025 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Percutaneous image-guided ablation (IGA) has emerged as an established alternative to surgical management for small renal masses. This comprehensive review examines traditional and emerging … |
| ECT | Holanda et al · Bioelectricity | 2025 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · hem intravenöz hem intratümöral | – | Electrochemotherapy (ECT) has emerged as an effective local treatment for cancer in dogs and cats. This technique consists of the transient and reversible permeabilization of cell membranes … |
| ECT | Iorga et al · Medicina (Kaunas) | 2025 | Derleme | İnsan | – | – | – | bleomisin | tam yanıt 46% | Skin metastases represent a rare finding in dermatological practice, but their presence signifies an advanced disease and usually portends a poor prognosis. They commonly arise as multiple p… |
| ECT | Maglietti et al · Mundo Saúde | 2024 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Electrochemotherapy is an innovative technology used to treat skin and mucosal cancers. It consists of intravenous administration of bleomycin followed by the application of electroporation … |
| ECT | Sun et al · Int J Surg | 2024 | Derleme | İnsan | Hemostaz ve Kanama Kontrolü | – | – | – | nesnel yanıt 80% (20 hasta) | Dear Editor, Angiosarcomas, which account for 1–2% of all head and neck sarcomas, are extremely rare malignancies that penetrate local structures through anaplastic vascular or lymphatic cel… |
| Diğer EP | Baeza-Hernández et al · Cancers (Basel) | 2023 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans and has the potential to progress locally, metastasize, and cause death in a subset of patients. cSCC is… |
| ECT | Campana et al · Clin Oncol (R Coll Radiol) | 2020 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | tam yanıt 54% | Electrochemotherapy and Enable Comparisons with Other Skindirected Therapies Madam d We welcome the recent overview of electrochemotherapy (ECT) and other skin-directed treatments [1]. Local… |
| ECT | Alagkiozidis · Int J Surg | 2019 | Derleme | İnsan | – | – | – | bleomisin | lokal kontrol 68% | International Journal of Surgery 72 (2019) 196–197 Contents lists available at ScienceDirect International Journal of Surgery journal homepage: www.elsevier.com/locate/ijsu Invited Commentar… |
| ECT | Campana et al · Semin Oncol | 2019 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 61 / 171 | – | bleomisin · intravenöz | – | Treatment of superficial tumors with electrochemotherapy (ECT) has shown a steep rise over the past decade and indications range from skin cancers to locally advanced or metastatic neoplasms… |
| Diğer EP | Kovács · J Contemp Brachytherapy | 2019 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – · intravenöz | – | Local non-surgical interventional percutaneous ablation represents nowadays an important part of the potential treatment strategies. Although surgical ablation represents the gold standard, … |
| ECT | O'Donoghue et al · Clin Oncol (R Coll Radiol) | 2019 | Derleme | İnsan | – | – | – | bleomisin · intravenöz | nesnel yanıt 93.8% (246 hasta) | Although surgery and radiotherapy remain the most commonly used treatments for non-melanoma skin cancer, there are a variety of alternatives. Here we discuss the use of electrochemotherapy a… |
| ECT | Zhou et al · Int J Surg | 2019 | Derleme | İnsan | – | – | – | – | – | Bu yayında özet bulunmuyor. |
| Kalsiyum EP | Frandsen et al · Technol Cancer Res Treat | 2018 | Derleme | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Reversible Membran Permeabilizasyonu | – | – | kalsiyum klorür | – | Calcium electroporation is a potential novel anticancer treatment, where high concentrations of calcium are introduced into the cell cytosol by electroporation. This is a method where short,… |
| ECT | Gehl et al · Acta Oncol | 2018 | Derleme | İnsan | – | – | – | bleomisin · intravenöz | nesnel yanıt 80% | Electrochemotherapy is now in routine clinical use to treat cutaneous metastases of any histology, and is listed in national and international guidelines for cutaneous metastases and primary… |
| ECT | Clover et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | – | – / 351 | – | bleomisin · intratümöral | nesnel yanıt 99% (351 lezyon) | Basal Cell Carcinoma (BCC) represents an evolving clinical challenge. It is the most common form of skin cancer and is increasing in prevalence due to aging populations and greater recreatio… |
| ECT | Snoj et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | – | – | – | bleomisin · intravenöz | nesnel yanıt 85% (642 lezyon) | Cutaneous metastases are fairly frequent manifestation of advanced malignant disease, comprising about 0.7–9% of all cancer patients. The cutaneous metastases may present itself as an isolat… |
| ECT | Queirolo et al · Arch Dermatol Res | 2014 | Derleme | Hayvan (İn Vivo) | – | – | – | bleomisin · intravenöz | – | Despite surgical treatment of primary tumor, about 5-10 % of melanoma patients will eventually suffer from cutaneous or subcutaneous metastasis. The presence of skin metastases decreases pat… |
| Diğer EP | Kähler et al · J Dtsch Dermatol Ges | 2013 | Derleme | İnsan | – | – | – | bleomisin · intravenöz | – | Patients with metastatic melanoma, but also other solid tumors (e.g., lung or breast cancer), may develop cutaneous metastases in advanced stages. The goal of treatment is to alleviate sympt… |
| ECT | Muñoz Madero et al · Clin Transl Oncol | 2011 | Derleme | İnsan | Reversible Membran Permeabilizasyonu | – / 171 | – | bleomisin · intravenöz | tam yanıt 73.7% (171 lezyon) | Electrochemotherapy (ECT) is a therapeutical procedure based on the induction of cell membrane electroporation, by cell exposure to electric fields lasting a few microseconds, combined with … |
| ECT | Reinhold · Hautarzt | 2011 | Derleme | İnsan | – | – / 1009 | – | bleomisin | – | Electrochemotherapy represents a new innovative technology using a combination of electroporation and application of very low dose cytotoxic drugs for the treatment of cutaneous and subcutan… |
| ECT | Sersa et al · Annu Int Conf IEEE Eng Med Biol Soc | 2011 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin | – | Electrochemotherapy consists of administration of the chemotherapeutic drug followed by application of electric pulses to the tumor, in order to facilitate the drug uptake into the cells. On… |
| ECT | Testori et al · Dermatol Ther | 2010 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – / 608 | – | bleomisin · intravenöz | – | Electroporation uses pulsed, high-intensity electric fields to temporarily increase cell membrane permeability by creation of pores, through which small molecules, such as chemotherapeutic a… |
| Gen ET | Mir · Mol Biotechnol | 2009 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | – | plazmid DNA | – | About 25 years after the publication of the first report on gene transfer in vitro in cultured cells by the means of electric pulses delivery, reversible cell electroporation for gene transf… |
| ECT | Colombo · Ther Clin Risk Manag | 2008 | Derleme | Literatür Analizi | – | – | – | bleomisin · intratümöral | nesnel yanıt 74.1% | Introduction: Tumors of any histological origin can give rise to cutaneous and subcutaneous metastases during follow-up. This study aims to evaluate the costs and benefits of electrochemothe… |
| ECT | Giardino et al · Biomed Pharmacother | 2006 | Derleme | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin | – | Electrochemotherapy (ECT) is a new treatment for metastatic nodules of solid tumors on the skin or subcutaneous tissue. ECT is a combination of a physical effect, cell membrane poration, and… |
| Diğer EP | Silva-Pilipich et al · Mol Ther Nucleic Acids | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım | – | BTX ECM830, Gene Pulser | – · intratümöral | – | Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for ant… |
| ECT | Garcia-Sanchez et al · IEEE Trans Biomed Eng | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | – | – | bleomisin · intravenöz | tam yanıt 42% (7 hayvan) | Objective: The purpose of this work is to assess the ability of sine waves to perform electrochemotherapy (ECT) and to study the dependence of the frequency of the applied sine wave on the t… |
| IRE | Guenther et al · PeerJ | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 19 | E2 generator prototype | – | – | Background: Percutaneous image-guided tissue ablation (IGA) plays a growing role in the clinical management of solid malignancies. Electroporation is used for IGA in several modalities: irre… |
| ECT | Weissman et al · Journal of Exotic Pet Medicine | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Hemostaz ve Kanama Kontrolü | – | – | bleomisin · intravenöz | – | Background: With increasing numbers of Vietnamese pot-bellied pigs (Susscrofa) being cared for as pets and increased survival times due to improved husbandry and veterinary care, the possibi… |
| ECT | Chopra et al · Int J Mol Sci | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Gen Elektrotransferi (Plazmid DNA) | – | BTX T820 | bleomisin | – | Electrochemotherapy is an efficient method for the local treatment of cutaneous and subcutaneous metastases, but its efficacy as a systemic treatment remains low. The application of gene ele… |
| ECT | Racnik et al · Radiol Oncol | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – / 4 | – | bleomisin · intratümöral | tam yanıt 4 adet (4 lezyon) | Background: Mast cell tumour, sebaceous gland adenoma, and less common squamous papilloma are skin tumours in ferrets ( Mustela putorius furo ), and early excisional surgery is usually the t… |
| Kalsiyum EP | Szewczyk · Oncotarget | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Kalsiyum Homeostazının Bozulması | – | BTX T820, Cliniporator | kalsiyum klorür · intratümöral | – | Calcium electroporation (CaEP) describes the use of electric pulses (electroporation) to transiently permeabilize cells to allow supraphysiological doses of calcium to enter the cytosol. Cal… |
| ECT | Zhao et al · Theranostics | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | BTX ECM830 | bleomisin · intratümöral | tümör hacmi değişimi 1.27 oran | Electrochemotherapy (ECT), as one of the very few available treatments for cutaneous and subcutaneous tumors when surgery and radiotherapy are no longer available, requires applying a proper… |
| IRE | Wang et al · Biomed Microdevices | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Irreversible electroporation (IRE) is a kind of promising cancer treatment technology. However, local recurrence still occurs because of incomplete ablation. The aim of this study was to inv… |
| Diğer EP | Cutrera et al · J Cell Mol Med | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Bleomisin Hücre İçi Birikiminin Artması | – / 19 | BTX 830 pulse generator | bleomisin · intratümöral | genel sağkalım 287 gün (13 hasta) | Electroporation improves the anti-tumour efficacy of chemotherapeutic and gene therapies. Combining electroporation-mediated chemotherapeutics with interleukin 12 (IL-12) plasmid DNA produce… |
| ECT | Suzuki et al · Artif Organs | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi, Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM830 | bleomisin · intravenöz | tam yanıt 1 adet (1 hayvan) | The combination of chemotherapy drugs and high electric field treatment in local cancer is named electrochemotherapy. The European Standard Operation Procedure of Electrochemotherapy (ESOPE)… |
| Gen ET | Guo · PLoS One | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | – | UltraVolt Model: Rack-2-500-00230 | plazmid DNA · intratümöral | – | Topical gene delivery to the epidermis has the potential to be an effective therapy for skin disorders, cutaneous cancers, vaccinations and systemic metabolic diseases. Previously, we report… |
| Diğer EP | Zibert et al · J Clin Invest | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Cliniporator | – | – | Dysregulated angiogenesis is a hallmark of chronic inflammatory diseases, including psoriasis, a common skin disorder that affects approximately 2% of the population. Studying both human pso… |
| ECT | Tsoneva et al · J Biomed Biotechnol | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – / 30 | – | sisplatin · intratümöral | tümör hacmi değişimi 10% (3 lezyon) | In the present study it is shown that poloxamer 188, added before or immediately after an electrical pulse used for electroporation, decreases the number of dead cells and at the same time d… |
| Diğer EP | Liu et al · J Cell Physiol | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | BTX ECM830 | plazmid DNA · intratümöral | – | Wound healing is impaired in elderly patients with diabetes mellitus. We hypothesized that age-dependent impairment of cutaneous wound healing in db/db diabetic mice: (a) would correlate wit… |
| ECT | Reberšek et al · Bioelectrochemistry | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | EP-GMS 7.1 | bleomisin · intravenöz | tam yanıt 57% (7 hayvan) | Electrochemotherapy is a treatment based on combination of chemotherapeutic drug and electroporation. It is used in clinics for treatment of solid tumours. For electrochemotherapy of larger … |
| ECT | Roux et al · Cancer Immunol Immunother | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Sistemik / Abskopal İmmün Yanıt | – | – | – · intravenöz | – | Purpose: Electrochemotherapy (ECT) is an effective local therapy of human cutaneous cancers but has no effect on distant untreated tumors. We addressed whether tumor-associated antigens rele… |
| ECT | Larkin et al · Ann Surg | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | 30 / 111 | Cliniporator, BTX ECM 2001 | bleomisin · hem intravenöz hem intratümöral | tam yanıt 60% (111 lezyon) | Objective: To develop an optimized, reproducible system of electrochemotherapy, and to investigate its clinical application in patients with cutaneous or subcutaneous recurrences of inoperab… |
| IRE | Al-Sakere · PLoS One | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | Cliniporator, GHT 1287 | – | tam yanıt 92% (13 lezyon) | We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a ne… |
| ECT | Torrero et al · Clin Cancer Res | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, İnterlökin-12 Aracılı İmmün Uyarım | – | – | bleomisin · intratümöral | tam yanıt 40% (5 hayvan) | Purpose: Bleomycin electrochemotherapy has been successfully used in preclinical studies and clinical trials for treating squamous cell carcinoma (SCC) and adenocarcinoma; however, it is not… |
| Diğer EP | Goto et al · Mol Ther | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | BTX T830 square-wave electroporator | – · intratümöral | tam yanıt 0.909091 oran (11 lezyon) | We report the use of plasmid DNA-mediated combination gene therapy for tumor-bearing mice using in vivo electroporation, also called electro-gene therapy (EGT), that resulted in uncomplicate… |
| ECT | Sersa et al · Br J Cancer | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Vasküler Kilit (Vascular Lock) Etkisi | – | Jouan GHT 1287 | sisplatin · intravenöz | tümör hacmi değişimi 9.4 gün | Electrochemotherapy is an antitumour treatment that utilises locally delivered electric pulses to increase cytotoxicity of chemotherapeutic drugs. Besides increased drug delivery, applicatio… |
| ECT | Wolff et al · Int J Mol Sci | 2022 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Bleomisin Hücre İçi Birikiminin Artması | – | BTX ECM830 | diğer · diğer yol | – | Despite continuous advancement in skin cancer therapy, the disease is still fatal in many patients, demonstrating the need to improve existing therapies, such as electrochemotherapy (ECT). E… |
| ECT | Bisceglia et al · COMPEL: The International Journal for Computation and Mathematics in Electrical and Electronic Engineering | 2013 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin | – | Purpose – Electrochemotherapy (ECT) is an outstanding technique for treatment of tumor nodules which is currently used for treatment of skin metastases, and now it is being developed for tre… |
| ECT | Meulenberg et al · PLoS One | 2012 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Vasküler Kilit (Vascular Lock) Etkisi | – | – | bleomisin | hücre canlılığı 31% | In vivo electroporation of tumours shows disruption of blood flow and creates a vascular effect with an initial rapid and transient vasoconstriction phase and a much longer lasting phase wit… |
| ECT | Kubota et al · Journal of Urology | 1998 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 1 / 17 | – | bleomisin · intratümöral | tam yanıt 14 adet (17 lezyon) | No AccessJournal of UrologyClinical Urology: Case Reports1 Oct 1998SUCCESSFUL TREATMENT OF METASTATIC SKIN LESIONS WITH ELECTROCHEMOTHERAPY YOKO KUBOTA, LLUIS M. MIR, TERUHIRO NAKADA, ISOJI … |
| IRE | Ongaro et al · Technol Cancer Res Treat | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | bleomisin | progresyonsuz sağkalım 80% (100 hasta) | Electrochemotherapy is an emerging local treatment for the management of superficial tumors and, among these, also chest wall recurrences from breast cancer. Generally, the treatment of this… |
| ECT | Forjanič et al · Med Biol Eng Comput | 2016 | İn Siliko / Modelleme | Hesaplamalı Model | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin | – | The effectiveness of electrochemotherapy, a local treatment using electric pulses to increase the uptake of chemotherapeutic drug, includes several antitumor mechanisms. In addition to the c… |
| ECT | Pavselj et al · IEEE Trans Biomed Eng | 2005 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Doku İletkenliği ve Empedans Değişimi | – | PS 15 | – | – | One of the ways to potentiate antitumor effectiveness of chemotherapeutic drugs is by local application of short intense electric pulses. This causes an increase of the cell membrane permeab… |
| IRE | Wardhana · Int J Comput Assist Radiol Surg | 2024 | Teknik / Cihaz Çalışması | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Purpose: Accurate needle placement is crucial for successful tumor treatment using the irreversible electroporation (IRE) method. Multiple needles are inserted around the tumor, ideally in p… |
| Gen ET | Kos · Mol Ther Nucleic Acids | 2016 | Teknik / Cihaz Çalışması | – | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | – | Cliniporator | plazmid DNA · diğer yol | – | Skin is an attractive target for gene electrotransfer. It consists of different cell types that can be transfected, leading to various responses to gene electrotransfer. We demonstrate that … |
| ECT | Sersa et al · J Vis Exp | 2008 | Teknik / Cihaz Çalışması | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | nesnel yanıt 80% | Electrochemotherapy is a combined use of certain chemotherapeutic drugs and electric pulses applied to the treated tumour nodule. Local application of electric pulses to the tumour increases… |
| ECT | Tokmakçı · J Med Syst | 2006 | Teknik / Cihaz Çalışması | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Electrochemotherapy (ECT) is a new method that uses anticancer drugs delivery with intensive electrical pulses. Recently, ECT as the treatment method can be applied for basal cell and spin c… |
| Belirlenmedi | Di Chiacchio · – | 2019 | Tez | – | – | 44 / 44 | – | bleomisin · intratümöral | tam yanıt 85.7% (21 hasta) | Bu yayında özet bulunmuyor. |
| ECT | Bogataj et al · Socratic Lectures 7 | 2022 | Kongre Özeti | – | Bleomisin Hücre İçi Birikiminin Artması | 1 / 1 | Cliniporator VITAE | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Squamous cutaneous skin cancer is common cancer with increasing incidence. Commonly is treated with surgery or radiotherapy, but a new technique has been emerging in recent years. Electroche… |
| ECT | Perusseau-Lambert et al · Cureus | 2025 | Editöryal / Mektup | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin · intratümöral | – | Skin malignancies such as basal cell carcinoma, squamous cell carcinoma, and melanoma are increasingly prevalent in the UK, particularly among frail and elderly patients who are often unsuit… |
| ECT | Li · J Surg Oncol | 2022 | Editöryal / Mektup | İnsan | – | – | – | – | – | Wai‐Yee Li MD, PHD We thank our learned colleagues, Campana and Gehl, for drawing our carcinoma of head and neck, and others.1 We would like to thank attention to the promising results on th… |
| ECT | Kunte et al · Eur J Surg Oncol | 2020 | Editöryal / Mektup | İnsan | – | – | – | bleomisin | – | The need for timely referral and comprehensive reporting Keywords: Skin metastases Electrochemotherapy Palliative care Scientific reporting Treatment outcome The article by Josephine Morley a… |
| ECT | Anon · Future Oncol | 2015 | Düzeltme / Erratum | – | – | – | – | – | – | Bu yayında özet bulunmuyor. |
| ECT | Tolstrup et al · J Vis Exp | 2026 | Protokol | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | 55 / 110 | – | bleomisin · intravenöz | – | Cutaneous metastases in patients with incurable cancer represent a significant problem as they often cause pain, discomfort, and emotional distress that affect everyday life. Finding treatme… |
| ECT | Tolstrup et al · Bioelectricity | 2025 | Protokol | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 55 / 110 | Cliniporator | bleomisin · intravenöz | – | Introduction: Cutaneous metastases in patients with incurable cancer can severely impact quality of life, highlighting the need for minimally invasive treatment options. Electrochemotherapy … |
| ECT | Vega Díez et al · Actas Dermo-Sifiliográficas | 2022 | Belirtilmemiş | – | – | 987 | – | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 98% | Bu yayında özet bulunmuyor. |
| Kalsiyum EP | Vissing · BMJ Open | 2021 | Protokol | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Kalsiyum Homeostazının Bozulması | 30 | Cliniporator | kalsiyum klorür · intratümöral | – | Introduction: Skin malignancy is a distressing problem for many patients, and clinical management is challenging. This article describes the protocol for the Calcium Electroporation Response… |
| ECT | Brizio · cderm | 2017 | Belirtilmemiş | – | – | – | – | diğer | – | Bu yayında özet bulunmuyor. |
| ECT | Olasz et al · Br J Dermatol | 2016 | Belirtilmemiş | İnsan | – | – | – | bleomisin · intravenöz | – | Linked Article:Sommerlad et al. Br J Dermatol 2016; 175:1342–1345. |
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