Vulvar Kanser
Ürojinekolojik Tümörler
Vulvar kanserde elektrokemoterapi, cerrahi morbiditesinin yüksek olduğu ve nüks eden hastalıkta organ koruyucu bir seçenek olarak değerlendirilir. Palyatif bağlamda semptom ve lokal kontrol hedeflenir.
30toplam yayın
19klinik çalışma
2preklinik çalışma
5derleme
1997–2026yayın aralığı
Rejime Göre Kanıt Durumu
Reversible elektroporasyon (RE-ECT)
29yayın
18klinik
2preklinik
Klinik Kanıt
1997–2026 · Rutin Klinik Kullanımda
İrreversible elektroporasyon (IRE-ECT)
1yayın
1klinik
0preklinik
Keşifsel Kanıt
2017–2017 · Erken Araştırma Aşamasında
Bu Alanda Raporlanan Mekanizmalar
Terimler, yayın özetleri üzerinde otomatik eşleştirmeyle saptanmıştır; rakam terimin geçtiği yayın sayısını gösterir.
Bleomisin Hücre İçi Birikiminin Artması 14
Sisplatin Hücre İçi Birikiminin Artması 3
Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu 2
Kas Kasılması ve Anestezi Gereksinimi 2
Nekroz ve Nekroptoz 1
Sistemik / Abskopal İmmün Yanıt 1
Kalsiyum Elektroporasyonu ve ATP Tükenmesi 1
Antivasküler Etki ve Damar Yıkımı 1
İrreversible Por Oluşumu ve Hücre Ölümü 1
Reversible Membran Permeabilizasyonu 1
Çalışma Tipi Dağılımı
Çubuk uzunluğu en kalabalık çalışma tipine göre ölçeklenmiştir; yüzde ise alanın tamamındaki payı verir. Renk, çalışma tipinin kanıt basamağını gösterir; kanıt haritasındaki ile aynı ölçek.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Randomize Klinik Çalışma | 1 | %3 |
| Prospektif Klinik Çalışma | 1 | %3 |
| Klinik Çalışma | 11 | %37 |
| Retrospektif Klinik Çalışma | 4 | %13 |
| Vaka Serisi | 2 | %7 |
| Vaka Raporu | 2 | %7 |
| Sistematik Derleme / Meta-Analiz | 3 | %10 |
| Derleme | 2 | %7 |
| Hayvan Çalışması | 1 | %3 |
| İn Vitro Çalışma | 1 | %3 |
| Kongre Özeti | 1 | %3 |
| Editöryal / Mektup | 1 | %3 |
Literatür Kanıt Tablosu
30 yayın, kanıt gücü sırasına göre listelenmiştir. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Özet |
|---|---|---|---|---|---|---|
| Reversible | Vivod et al · Acta Oncol | 2024 | Randomize Klinik Çalışma | İnsan | – | Background: Electrochemotherapy (ECT) is a combined treatment method based on electroporation and simultaneous chemotherapy. In cases where radiotherapy has previously been used, surgery is … |
| Reversible | Perrone et al · Cancers (Basel) | 2021 | Prospektif Klinik Çalışma | İnsan | – | The ELECHTRA (ELEctroChemoTherapy vulvaR cAncer) project was conceived to collect data on palliative electrochemotherapy (ECT) in vulvar cancer (VC) assessing patients' outcomes (response an… |
| Reversible | Vivod et al · Radiol Oncol | 2025 | Klinik Çalışma | İnsan | – | Background: The quality of life of patients undergoing oncologic treatment has become an important issue in recent years. Owing to potential mutilation following surgery for vulvar cancer, m… |
| Reversible | Perrone et al · Int J Gynecol Cancer | 2023 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Objective: The management of vulvar cancer recurrences is complicated by patients' advanced age and comorbidities. Bleomycin-based electrochemotherapy is a potential treatment option in this… |
| Reversible | Vivod et al · Cancers (Basel) | 2023 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy is a local ablative therapy used for the treatment of various superficial and deep-seated tumors. Electrochemotherapy involves the application of electric pulses locally … |
| Reversible | Corrado et al · International Journal of Gynecological Cancer | 2020 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 435 Figure 1 A180 Int J Gynecol Cancer 2020;30(Suppl 3):A1–A210 Abstracts Methods Data were retrospectively collected from November 2017 to November 2019 in two Italian oncologic Institutes:… |
| Reversible | Corrado et al · Int J Gynecol Cancer | 2020 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | Objective: Since vulvar cancer is such a rare disease, the international experience with electrochemotherapy has been derived from only a few centers. The aim of this study was to evaluate c… |
| Reversible | Perrone et al · Int J Gynecol Cancer | 2020 | Klinik Çalışma | İnsan | Sistemik / Abskopal İmmün Yanıt, Bleomisin Hücre İçi Birikiminin Artması | Objective: Vaginal metastases are very rare events with a poor prognosis. To improve the quality of life, local treatments should be considered. The aim of this study was to evaluate the rol… |
| Reversible | Perrone et al · Cancers (Basel) | 2019 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Vulvar cancer (VC) is a rare disease of which recurrence poses management problems due to patients' advanced age and comorbidities, and to the localization of the disease. Palliative treatme… |
| Reversible | Perrone et al · J Surg Oncol | 2018 | Klinik Çalışma | İnsan | – | Background and objectives: Previous studies showed a local tumor control of 80% in patients with relapsed squamous cell vulvar cancer (V-SCC) treated with electrochemotherapy. These results … |
| Reversible | Pellegrino et al · Acta Oncol | 2016 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Objective To evaluate the safety, local tumor efficacy and relief of symptoms of electrochemotherapy (ECT) treatment in patients affected by recurrence of vulvar cancer (VC), unsuitable for … |
| Reversible | Perrone et al · J Surg Oncol | 2015 | Klinik Çalışma | İnsan | – | Objective: The primary endpoint of this trial was to assess clinical response (cCR) of squamocellular vulvar cancer (V-SCC) in elderly patients treated with electro-chemotherapy (ECT). Secon… |
| Reversible | Perrone et al · Gynecol Oncol | 2013 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | Objective: Electrochemotherapy (ECT) is an attractive treatment for solid cutaneous tumours with a good response rate (55-92%). No studies have evaluated ECT performed in vulvar cancer. The … |
| Reversible | Federico et al · International Journal of Gynecological Cancer | 2025 | Retrospektif Klinik Çalışma | İnsan | – | /Background Definitive chemoradiation (d-CRT) is the standard treatment for vulvar squamous cell carcinoma (VSCC) with pelvic lymph node (PLN) involvement (stage IVB). The potential benefit of… |
| Reversible | Fernandez et al · International Journal of Gynecological Cancer | 2022 | Retrospektif Klinik Çalışma | İnsan | – | 2022-RA-642-ESGO Figure 1 A) Progression free survival (PFS) and B) Overall survival of patients treated with ECT for recurrent vulvar sequamous cellular carcinoma Conclusion Long follow-up … |
| Reversible | Perrone et al · International Journal of Gynecological Cancer | 2022 | Retrospektif Klinik Çalışma | İnsan | – | 2022-RA-642-ESGO Figure 1 A) Progression free survival (PFS) and B) Overall survival of patients treated with ECT for recurrent vulvar sequamous cellular carcinoma Conclusion Long follow-up … |
| Reversible | Vivod et al · Technol Cancer Res Treat | 2022 | Retrospektif Klinik Çalışma | İnsan | – | Objective : Pelvic exenteration in women with recurrent vulvar carcinoma is associated with high morbidity and mortality and substantial treatment costs. Because pelvic exenteration severely… |
| Reversible | Grischke et al · Arch Gynecol Obstet | 2026 | Vaka Serisi | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: Vulvar carcinoma (VC), a rare cancer, recurs in over a third of women, usually within 2 years. Treatment options other than repeat surgery and radiotherapy are often required in … |
| İrreversible | Vroomen et al · Cardiovasc Intervent Radiol | 2017 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objective: To describe the initial experience with irreversible electroporation (IRE) to treat pelvic tumor recurrences. Methods: A retrospective single-center analysis was performed. Advers… |
| Reversible | Vivod et al · Radiol Oncol | 2023 | Vaka Raporu | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Antivasküler Etki ve Damar Yıkımı | Background: Electrochemotherapy has good local effectiveness in the treatment of vulvar cancer. Most studies have reported the safety and effectiveness of electrochemotherapy for palliative … |
| Reversible | Merlo et al · Technol Cancer Res Treat | 2021 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Endometrial carcinoma is the most common gynecological malignancy and the fifth most common malignancy in women. The worldwide incidence is 15.9 new cases per 100,000 women per year, and the… |
| Reversible | Perrone et al · Cancers (Basel) | 2021 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | Sisplatin Hücre İçi Birikiminin Artması, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) is an emerging treatment for solid tumors and an attractive research field due to its clinical results. This therapy represents an alternative local treatment to th… |
| Reversible | Certelli et al · It Journ Gyn Obs | 2020 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | SOMMARIO There are some problems about the optimal treatment modality of vulvar cancer (VC): unfeasible surgery in elderly women with several comorbidities and the absence of treatments appl… |
| Reversible | Tranoulis et al · Int J Gynecol Cancer | 2020 | Sistematik Derleme / Meta-Analiz | İnsan | – | Introduction: Electrochemotherapy involves the use of transient tumor permeabilization via electric pulses in combination with low-dose chemotherapeutic agents. It has recently emerged as an… |
| Reversible | Restaino · Cancers (Basel) | 2025 | Derleme | Literatür Analizi | – | Background: Vulvar carcinoma is an uncommon gynecological tumor primarily affecting older women. Its treatment significantly impacts the quality of life and, not least, aesthetics because of… |
| Reversible | Łapińska et al · Molecules | 2022 | Derleme | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | Gynecological carcinomas affect an increasing number of women and are associated with poor prognosis. The gold standard treatment plan is mainly based on surgical resection and subsequent ch… |
| Reversible | Yabushita et al · Gynecol Oncol | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy is a new approach to the treatment of tumors that takes advantage of the permeabilization of the cell membranes by electric pulses to facilitate the intracellular deliver… |
| Reversible | Tang et al · Int J Oncol | 2005 | İn Vitro Çalışma | Hücre Kültürü | – | Electrochemical treatment is among the most effective therapies in the management of cervical malignancy. However, the mechanism of action of this treatment remains largely unknown. Therefor… |
| Reversible | Tranoulis et al · International Journal of Gynecological Cancer | 2019 | Kongre Özeti | – | – | EP1290 Figure 1 IJGC 2019;29(Suppl 4):A1–A703 THE POSSIBLE ROLE OF CELL POLARITY FOR CANCER DISEASE – THE IMPLICATION OF CANCER REGRESSION BY HUMAN BODY AXES INTERACTION 1 MC Ou*, 2D Ou, 3CC… |
| Reversible | De Giorgi et al · Int J Gynecol Cancer | 2020 | Editöryal / Mektup | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | t or metastatic vulvar cancer We read with great interest the papers by Perrone et al and Corrado et al evaluating the role of electrochemotherapy with intravenous infusion of bleomycin as a… |
Sınırlılıklar
Bu sayfadaki sayımlar kaynak PDF arşivinin kapsamıyla sınırlıdır ve alanın literatürünün sistematik bir taraması değildir. Çalışma tipi ve mekanizma etiketleri otomatik türetilmiştir; kritik kararlar için tablodaki yayınların tam metinlerine başvurulmalıdır. Kanıt düzeyi etiketi yayın sayısına dayanır, yayınların metodolojik kalitesine değil.