Meme Kanseri
Derin Organ Tümörleri
Meme kanserinin göğüs duvarı nüksleri ve deri metastazları, elektrokemoterapinin yerleşik kullanım alanlarındandır. Bu lezyonlar sıklıkla ışınlanmış dokuda gelişir, kanamalı ve kokulu olabilir; yöntemin lokal kontrol ve hemostatik etkisi yaşam kalitesi açısından belirleyici olabilir.
107toplam yayın
36klinik çalışma
44preklinik çalışma
8derleme
1991–2026yayın aralığı
Rejime Göre Kanıt Durumu
Reversible elektroporasyon (RE-ECT)
98yayın
35klinik
37preklinik
Klinik Kanıt
1991–2026 · Rutin Klinik Kullanımda
İrreversible elektroporasyon (IRE-ECT)
9yayın
1klinik
7preklinik
Preklinik Kanıt
2009–2026 · Klinik Araştırma Aşamasında
Bu Alanda Raporlanan Mekanizmalar
Terimler, yayın özetleri üzerinde otomatik eşleştirmeyle saptanmıştır; rakam terimin geçtiği yayın sayısını gösterir.
Bleomisin Hücre İçi Birikiminin Artması 30
Reversible Membran Permeabilizasyonu 18
Sisplatin Hücre İçi Birikiminin Artması 16
Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu 13
Darbe Parametrelerinin Optimizasyonu 13
Elektrik Alan Dağılımı ve Modellemesi 11
İrreversible Por Oluşumu ve Hücre Ölümü 11
Apoptoz İndüksiyonu 10
Mitokondriyal Disfonksiyon ve Oksidatif Stres 10
Elektrot Geometrisi ve Yerleşimi 9
Gen Elektrotransferi (Plazmid DNA) 8
Nekroz ve Nekroptoz 8
Çalışma Tipi Dağılımı
Çubuk uzunluğu en kalabalık çalışma tipine göre ölçeklenmiştir; yüzde ise alanın tamamındaki payı verir. Renk, çalışma tipinin kanıt basamağını gösterir; kanıt haritasındaki ile aynı ölçek.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Randomize Klinik Çalışma | 3 | %3 |
| Prospektif Klinik Çalışma | 2 | %2 |
| Klinik Çalışma | 28 | %26 |
| Retrospektif Klinik Çalışma | 2 | %2 |
| Vaka Serisi | 1 | <%1 |
| Vaka Raporu | 11 | %10 |
| Sistematik Derleme / Meta-Analiz | 1 | <%1 |
| Derleme | 7 | %7 |
| Hayvan Çalışması | 23 | %21 |
| İn Vitro Çalışma | 21 | %20 |
| Ön Baskı | 2 | %2 |
| Editöryal / Mektup | 3 | %3 |
| Düzeltme / Erratum | 2 | %2 |
| Belirtilmemiş | 1 | <%1 |
Literatür Kanıt Tablosu
107 yayın, kanıt gücü sırasına göre listelenmiştir. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Özet |
|---|---|---|---|---|---|---|
| Reversible | Tahvildari et al · Int J Cancer Manag | 2025 | Randomize Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background: Skin metastases occur in 5% - 30% of breast cancer patients, highlighting the need for effective treatments. Electrochemotherapy, which combines electric pulses with chemotherapy… |
| Reversible | Agresti et al · The Breast | 2017 | Randomize Klinik Çalışma | İnsan | – | The multicentre cohort analysis conducted by GISEL (Italian Senological Group for Electrochemotherapy) confirmed that Electrochemotherapy (ECT) has high antitumor activity (> 90% ORR) on ski… |
| Reversible | Rebersek et al · Anticancer Drugs | 2004 | Randomize Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması | We have evaluated the efficiency of electrochemotherapy with cisplatin on cutaneous tumor lesions of breast cancer and have compared its efficiency with the efficiency of intratumoral (i.t.)… |
| Reversible | Lekešytė et al · Pharmaceutics | 2024 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background/Objectives: Electrochemotherapy (ECT) is a safe and efficient method of targeted drug delivery using pulsed electric fields (PEF), one that is based on the phenomenon of electropo… |
| Reversible | Benevento et al · Int J Surg Case Rep | 2015 | Prospektif Klinik Çalışma | İnsan | – | Introduction: Angiosarcomas are highly malignant endothelial cell tumors with poor prognosis. These can be due to breast cancer itself or to subsequent therapeutic modalities. No evidence-ba… |
| Reversible | Russano et al · Clin Exp Metastasis | 2025 | Klinik Çalışma | İnsan | Sistemik / Abskopal İmmün Yanıt | Electrochemotherapy (ECT) is a local treatment combining chemotherapy with electroporation. This prospective multicentre study aimed to evaluate the efficacy of ECT in the treatment of patie… |
| Reversible | Aigner et al · Cancers (Basel) | 2024 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Background: Relapsed unresectable triple-negative breast cancer is a demanding disease with only a few treatment options. Especially for patients with unresectable tumor masses, a treatment … |
| Reversible | Bieżuńska-Kusiak et al · Pharmaceuticals (Basel) | 2023 | Klinik Çalışma | İnsan | – | Breast cancer ranks among the top three most common malignant neoplasms in Poland. The use of calcium ion-assisted electroporation is an alternative approach to the classic treatment of this… |
| Reversible | Di Prata et al · Cancers (Basel) | 2023 | Klinik Çalışma | İnsan | – | Electrochemotherapy has been proven to be an efficient treatment for cutaneous metastases of various cancers. Data on breast cancer (BC) patients with cutaneous metastases were retrieved fro… |
| Reversible | Giri et al · Explor Target Antitumor Ther | 2023 | Klinik Çalışma | İnsan | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Apoptoz İndüksiyonu | Aim: Triple negative breast cancer (TNBC) is difficult to treat since it lacks all the three most commonly targeted hormone receptors. Patients afflicted with TNBC are treated with platinum … |
| Reversible | Varadarajan et al · Appl Biochem Biotechnol | 2022 | Klinik Çalışma | İnsan | – | With the absence of the three most common receptor targets, and with high vascularity and higher-grade tumors, triple-negative breast cancer (TNBC) is the most aggressive of all breast cance… |
| Reversible | Matthiessen et al · Clin Breast Cancer | 2018 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: Cutaneous recurrence from breast cancer can pose a clinical challenge. It might be the only disease site, or could be part of disseminated disease, and often profoundly affects q… |
| Reversible | Vera-Tizatl et al · Technol Cancer Res Treat | 2018 | Klinik Çalışma | İnsan | Elektrot Geometrisi ve Yerleşimi, Elektrik Alan Dağılımı ve Modellemesi | Breast cancer represents a rising problem concerning public health worldwide. Current efforts are aimed to the development of new minimally invasive and conservative treatment procedures for… |
| Reversible | Wichtowski et al · Oncol Res Treat | 2018 | Klinik Çalışma | İnsan | – | Introduction: Breast cancer is responsible for more than 50% of cutaneous metastases. One of the treatment options is electrochemotherapy (ECT). It is an effective method of local tumor abla… |
| İrreversible | Mafeld et al · Cardiovasc Intervent Radiol | 2018 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Aim: Irreversible electroporation (IRE) is a non-thermal ablative option in patients unsuitable for standard thermal ablation, due to its potential to preserve collagenous structures (vessel… |
| Reversible | Grischke et al · Radiol Oncol | 2017 | Klinik Çalışma | İnsan | Nekroz ve Nekroptoz | Background: Electrochemotherapy (ECT) is an established procedure for treating breast cancer loco-regional recurrences following surgical intervention and/or radiotherapy. Limited informatio… |
| Reversible | Guida et al · Annals of Oncology | 2017 | Klinik Çalışma | İnsan | – | Recommendations for management of metastatic breast cancer (MBC) in elderly patients (pts) are limited because of this subgroup of pts are largely underrepresented in clinical studies and th… |
| Reversible | Banerjee et al · European Journal of Surgical Oncology (EJSO) | 2016 | Klinik Çalışma | İnsan | – | This study explores clinical decision-making in advanced level nurses. Areas of interest include the influences of education and experience in addition to contrasts between simple and comple… |
| Reversible | Matthiessen et al · Annals of Oncology | 2016 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | Cutaneous recurrence from breast cancer can pose a clinical challenge. It may be the only disease site, or be part of disseminated disease, and often profoundly impacts quality of life. Elec… |
| Reversible | Cabula et al · Ann Surg Oncol | 2015 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: The management of breast cancer (BC) skin metastases represents a therapeutic challenge. Electrochemotherapy (ECT) combines the administration of bleomycin with temporary permeab… |
| Reversible | Denzi et al · Biomed Eng Online | 2015 | Klinik Çalışma | İnsan | Nekroz ve Nekroptoz, Elektrot Geometrisi ve Yerleşimi | Background: Breast cancer is the most common cancer in women worldwide and is the second most common cause of cancer death in women. Electrochemotherapy (ECT) used in early-phase clinical tr… |
| Reversible | Kalavathy et al · JCPCR | 2015 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | Electrochemotherapy (ECT) is a local cancer treatment modality where the intracellular accumulation of a chemotherapeutic agent is enhanced in the presence of an electrical field by the phen… |
| Reversible | Mercantini et al · The American Surgeon™ | 2015 | Klinik Çalışma | İnsan | – | reast Cancer Electrochemotherapy (ECT) is a procedure that combines the administration of a chemotherapeutic drug and the local application of electroporation pulses. The physical basis of t… |
| Reversible | Sundararajan · JCPCR | 2015 | Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Bleomisin Hücre İçi Birikiminin Artması | Triple negative breast cancer (TNBC) has poor prognosis. This is due to lack of estrogen, progesterone and HER-2 receptors. About 15% of all breast cancers are TNBC. This year in the US alon… |
| Reversible | Schmidt et al · Geburtshilfe Frauenheilkd | 2014 | Klinik Çalışma | İnsan | – | Electrochemotherapy is a new method for the local treatment of cutaneous and subcutaneous metastases. If surgery and/or radiotherapy are no longer possible, this innovative technology can be… |
| Reversible | Campana et al · European Journal of Surgical Oncology (EJSO) | 2013 | Klinik Çalışma | İnsan | – | Utilisation of intra operative ultrasound to guide breast surgery, particularly for impalpable lesions can obviate the need for pre operative wire or similar localisation procedures. This re… |
| Reversible | Benevento et al · BMC Surg | 2012 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background: The management of cutaneous metastases often represents a challenge because they may be widespread and may recur after radiotherapy or chemotherapy; breast cancer accounts for 51… |
| Reversible | Cabula · European Journal of Surgical Oncology (EJSO) | 2012 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT), a new palliative treatment for cutaneous metastases, involves the delivery of electrical pulses to lesions several minutes after intravenous or intratumor injectio… |
| Reversible | Campana et al · Breast Cancer Res Treat | 2012 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) represents an attractive locoregional therapy for unresectable chest wall recurrence (CWR) from breast cancer. Thirty-five patients with cutaneous CWR after mastect… |
| Reversible | Matthiessen et al · Acta Oncol | 2012 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: Cutaneous recurrences of breast cancer may cause considerable discomfort due to ulceration, oozing, and pain and can also be difficult to treat. Electrochemotherapy is a localise… |
| Reversible | Sersa et al · Radiotherapy and Oncology | 2012 | Klinik Çalışma | İnsan | – | ESTRO 31 ELECTRONIC POSTER: RADIOBIOLOGY GENOMICS AND PROTEOMICS S601 TRACK: EP-1566 TESTING FOR BRACA1 AND BRACA 2 GERMLINE MUTATION UNAFFECTED MEMBERS IN FAMILIES WITH BREAST/OVARIAN CANCE… |
| Reversible | Matthiessen et al · European Journal of Cancer Supplements | 2009 | Klinik Çalışma | İnsan | – | Metastatic breast cancer (MBC) is an incurable disease, and thus removal of the primary tumour (PT) is not recommended in the routine management. However, several retrospective studies suppo… |
| Reversible | Whelan et al · European Journal of Cancer Supplements | 2006 | Klinik Çalışma | İnsan | – | The application of combined chemotherapy and cancer cell permeabilising electric pulses (electrochemotherapy) has been demonstrated here to be clinically effective in the treatment and contr… |
| Reversible | Russano et al · Front Oncol | 2021 | Retrospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | The treatment of cutaneous and subcutaneous localizations from breast cancer (BC) is still a therapeutic challenge. Electrochemotherapy (ECT) is one of the available options, and it is chara… |
| Reversible | Campana et al · J Cancer Res Clin Oncol | 2014 | Retrospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Purpose: To evaluate the efficacy and toxicity of electrochemotherapy (ECT) in elderly metastatic breast cancer (BC) patients. Methods: Retrospective analysis of 55 patients with superficial… |
| Reversible | Shahverdi et al · Int J Cancer Manag | 2026 | Vaka Serisi | İnsan | – | Background and Objective: Breast cancer (BC), the second most prevalent cancer worldwide, poses a significant health challenge. Despite major advances in therapeutic modalities for BC, patie… |
| Reversible | Mazzotti · IJCCR | 2024 | Vaka Raporu | İnsan | – | Electrochemotherapy represents one of the therapeutic breakthroughs in the oncology field. In this case report, we describe a woman diagnosed with breast cancer in 2005. The case was treated… |
| Reversible | Corrado et al · Anticancer Res | 2023 | Vaka Raporu | İnsan | – | Background: We present the case of a recurrent malignant phyllodes tumor of the breast, after mastectomy and radiotherapy, in which electrochemotherapy (ECT) was applied to the tumor bed, to… |
| Reversible | Campana et al · J Surg Case Rep | 2022 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | A 55-year-old woman with previous skin-sparing mastectomy and prosthetic reconstruction for multifocal ductal carcinoma developed homolateral axillary recurrence. Following nodal dissection,… |
| Reversible | Jensen · Case Rep Dermatol | 2022 | Vaka Raporu | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Kalsiyum Homeostazının Bozulması | We report a case of successful treatment of cutaneous metastases in HER2-positive breast cancer with calcium electroporation (CaEP), in addition to trastuzumab, over a period of 5 years. CaE… |
| Reversible | Esposito et al · Transl Cancer Res | 2021 | Vaka Raporu | İnsan | Nekroz ve Nekroptoz, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy has been shown to be safe, effective and non-invasive loco-regional treatment for chest wall breast cancer recurrence. Electrochemotherapy is a palliative treatment offer… |
| Reversible | Cencelj-Arnez et al · Radiol Oncol | 2020 | Vaka Raporu | İnsan | – | Background: Radiotherapy-associated angiosarcoma (RAA) of the breast is a rare complication of radiotherapy, which is often difficult to identify and has poor prognosis. It usually presents … |
| Reversible | Radica et al · AME Case Rep | 2020 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | Breast cancer is the most common cause of chest wall recurrence, skin, and subcutaneous tissue metastases which mainly occur as multiple nodes in the skin and subcutaneous tissue. When it oc… |
| Reversible | Mofid et al · Acta Med Iran | 2017 | Vaka Raporu | İnsan | Kas Kasılması ve Anestezi Gereksinimi | Electrochemotherapy (ECT) is a new local treatment method for solid and superficial tumors. During this new technique, patients experience an unpleasant sensation and slight edema. Most unpl… |
| Reversible | Mocerino et al · Int J Immunopathol Pharmacol | 2016 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Angiosarcomas are malignant tumors of endovascular origin, which may be divided into primary and secondary forms. Secondary breast angiosarcomas are an increasing problem, especially in pati… |
| Reversible | Wichtowski et al · Breast Care (Basel) | 2016 | Vaka Raporu | İnsan | – | Background: Chest wall recurrence (CWR) from breast cancer after mastectomy is a difficult to treat disease. Electrochemotherapy (ECT) provides a safe, efficient, and non-invasive locoregion… |
| Reversible | Cabula · Updates Surg | 2012 | Vaka Raporu | İnsan | – | Neoadjuvant electrochemotherapy of breast cancer: our experience on first case treated in Italy Carlo Cabula Received: 29 December 2010 / Accepted: 17 July 2012 / Published online: 12 August… |
| Reversible | Ferioli et al · Clin Exp Metastasis | 2020 | Sistematik Derleme / Meta-Analiz | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Skin metastases occur in 5-30% of breast cancer (BC) patients. Standard treatments include systemic therapies (chemotherapy, endocrine therapy, and immunotherapy) and local treatments (surge… |
| Reversible | Russano et al · Ther Adv Med Oncol | 2025 | Derleme | Literatür Analizi | – | Cutaneous metastases from breast cancer, although relatively uncommon, represent the most frequent form of skin metastases overall and pose a significant clinical and therapeutic challenge. … |
| Reversible | Russano et al · Biomedicines | 2025 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Cutaneous metastases from breast carcinoma represent a debilitating complication of advanced disease progression, significantly impacting patients' quality of life. Electrochemotherapy (ECT)… |
| Reversible | Parisi et al · J Clin Med | 2024 | Derleme | Literatür Analizi | – | Breast angiosarcoma is a rare malignancy, accounting for less than 1% of all soft tissue cancers. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS).… |
| Reversible | Campana et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | – | Skin metastases occur more commonly in breast cancer (BC) than in any other malignancy in women, exceeding 20% of all cutaneous metastases. They most commonly present on the chest wall (CW),… |
| Reversible | Wichtowski et al · Breast Care (Basel) | 2017 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Breast cancer is the most common cause of skin metastases in women. The probability of their occurrence ranges from about 5% in the entire population to as much as 30% in the late stages of … |
| İrreversible | Thomson et al · Tech Vasc Interv Radiol | 2015 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a novel nonthermal focal ablation technique that uses a series of brief but intense electric pulses delivered by paired electrodes into a targeted regio… |
| Reversible | Sersa et al · Cancer Treat Rev | 2012 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Chest wall breast cancer recurrence after mastectomy is a disease difficult to treat. Its incidence varies between 5% and 30% in different subset of patients. When possible, radical surgical… |
| Reversible | Radzevičiūtė-Valčiukė et al · Front Immunol | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Darbe Parametrelerinin Optimizasyonu | Calcium electrochemotherapy (CaECT) is an effective alternative to standard chemotherapeutic treatments, utilizing intracellular delivery of supraphysiological calcium concentrations to indu… |
| Reversible | YazdanParast et al · Biomedicines | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background : Electrochemotherapy enhances the intracellular delivery of anticancer agents through electroporation but is traditionally limited to cytotoxic drugs associated with significant … |
| Reversible | Barauskaitė-Šarkinienė et al · Int J Mol Sci | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, İrreversible Por Oluşumu ve Hücre Ölümü | Electrochemotherapy (ECT) uses electroporation to enhance drug delivery into tumor cells, triggering bystander effects like immunogenicity and cell death. This study investigated bystander e… |
| Reversible | Maciulevičius et al · Ultrason Sonochem | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Calcium-based treatments have gained considerable attention in the field of electroporation, primarily, due to their comparable efficacy to conventional electro-chemotherapy. However, their … |
| Reversible | Omerzel et al · Cancers (Basel) | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background : Electrochemotherapy (ECT) is a clinically validated local ablative treatment increasingly recognized for its ability to induce immunogenic cell death and stimulate antitumor imm… |
| Reversible | Bosnjak et al · Bioelectrochemistry | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, DNA Hasarı ve Çift Zincir Kırıkları | Electrochemotherapy (ECT), a local therapy, has different effectiveness among tumor types. In breast cancer, its effectiveness is low; therefore, combined therapies are needed. The aim of ou… |
| Reversible | Guo · Front Immunol | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness of systemic IL-15 administration as a monotherapy has not been r… |
| Reversible | Sundararajan et al · Biomedicines | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | – | In the US, every 12 min, six women are diagnosed with breast cancer and one dies. This highlights a critical need for developing alternate therapies using natural compounds, which are cost e… |
| Reversible | Savarin · Technol Cancer Res Treat | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Antivasküler Etki ve Damar Yıkımı, Gen Elektrotransferi (Plazmid DNA) | Vascular-targeted therapies exhibit radiosensitizing effects by remodeling tumor vasculature, thus facilitating the increased oxygenation of the remaining tumor tissue. To examine these phen… |
| Reversible | Lanza et al · J Vet Med Sci | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | Two male rats (Rattus norvegicus; 18 and 24 months old), were referred for treatment of large masses located in the axillary area. Following total body radiography and hematological and seru… |
| İrreversible | Zhang et al · PLoS One | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background and aim: Irreversible electroporation (IRE) was confirmed to control several solid tumors effectively in vivo. Our preclinical study aimed to assess the feasibility and safety of … |
| İrreversible | Zhang et al · Biomed Microdevices | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is considered predominantly as a non-thermal ablative technique that uses electrical fields to permeabilize cell membranes and lead to cell death. In this … |
| Reversible | Stimac · PLoS One | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | Vascular targeted therapies, targeting specific endothelial cell markers, are promising approaches for the treatment of cancer. One of the targets is endoglin, transforming growth factor-β (… |
| Reversible | Mahna et al · J Membr Biol | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | From a fundamental point of view, chemotherapy is the most widely used treatment for cancers despite its side effects on normal cells and tissues. Electrochemotherapy (ECT) is a method for i… |
| Reversible | Wezgowiec et al · Photodiagnosis Photodyn Ther | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background: Ineffective drug delivery is a vast problem of anticancer therapies. The aim of this study was to investigate the possibility of enhancement of cyanines transport through the cel… |
| Reversible | Raeisi et al · Radiol Oncol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | Background: The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cisplatin combined with suboptimal radiotherapy doses. Tumor radiosensitization w… |
| Reversible | Haller et al · Oncogene | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | The Notch ligand delta-like ligand 4 (DLL4) is an essential component expressed by endothelial tip cells during angiogenic sprouting. We have described a conceptually novel therapeutic strat… |
| Reversible | Shibata · BMC Med | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Apoptoz İndüksiyonu | Background: Cancer metastasis contributes significantly to cancer mortality and is facilitated by lymphangiogenesis and angiogenesis. A new splicing variant, endogenous soluble vascular endo… |
| İrreversible | Neal et al · Breast Cancer Res Treat | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating… |
| Reversible | Shibata et al · Cancer Gene Ther | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Cancer metastasis contributes significantly to cancer mortality and is facilitated by lymphangiogenesis and angiogenesis. Vascular endothelial growth factor-C (VEGF-C) and VEGF-A are involve… |
| Reversible | Curcio et al · Cancer Gene Ther | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | – | A recently developed, adaptive constant-current electroporation technique was used to immunize mice with an intramuscular injection of plasmid coding for the extracellular and transmembrane … |
| Reversible | Wells et al · Gene Ther | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | Electroporation was applied to enhance gene transfer into subcutaneous MC2 murine breast tumors. Cultured MC2 cells were also transfected by electroporation or by cationic liposomes in the p… |
| Reversible | Belehradek et al · Eur J Cancer | 1991 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy delivers external electric pulses to the tumour site to induce local potentiation of the antitumour activity of intramuscular injections of bleomycin. C3H/Bi mice with sp… |
| Reversible | Li · Mater Today Bio | 2026 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | Triple-negative breast cancer (TNBC) exhibits high local-recurrence risk despite modern systemic therapy assisted with surgery or irradiation therapy. Here, we report an injectable nano-in-m… |
| Reversible | Rembiałkowska et al · Bioelectrochemistry | 2026 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Mitokondriyal Disfonksiyon ve Oksidatif Stres | Electrochemotherapy (ECT), combining pulsed electric fields (PEFs) with cytotoxic drugs, enhances intracellular drug delivery and tumor control; however, cellular stress responses determinin… |
| İrreversible | Wei et al · Bioelectrochemistry | 2026 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, İmmünojenik Hücre Ölümü (ICD) | This study aimed to investigate the synergistic effect of cold atmospheric plasma (CAP) and pulsed electric field (PEF) in inducing immunogenic cell death (ICD) in triple-negative breast can… |
| Reversible | Michel et al · Front Oncol | 2025 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Nanosaniye Darbeli Elektrik Alan (nsPEF) | Introduction: Electroporation (EP) is a technique that transiently increases the permeability of the cell membrane through the application of high-voltage electric pulses, facilitating the i… |
| Reversible | Bute et al · Med Oncol | 2022 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu | Traditional cancer treatments, such as chemotherapy and radiotherapy have several limitations. Therefore, their performance must be enhanced with combined methods. The purpose of this study … |
| Reversible | Rembiałkowska et al · Molecules | 2022 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Darbe Parametrelerinin Optimizasyonu | (1) Background: Pulsed electric field (PEF) techniques are commonly used to support the delivery of various molecules. A PEF seems a promising method for low permeability drugs or when cells… |
| İrreversible | Jiang et al · Biosensors (Basel) | 2022 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a non-thermal tumor ablation technique that delivers short pulses of strong electric fields to cancer tissues and induces cell death through the destruc… |
| Reversible | Abd-Elghany · Electromagn Biol Med | 2021 | İn Vitro Çalışma | Hücre Kültürü | Nanosaniye Darbeli Elektrik Alan (nsPEF), Reversible Membran Permeabilizasyonu | The study aimed to evaluate the possibility to perform electrochemotherapy using nanosecond pulsed electric field (nsPEF) and low electric field (LEF) monopolar electrical impulses to allevi… |
| Reversible | Sundararajan et al · Appl Biochem Biotechnol | 2021 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | Heat shock proteins (HSPs) are available and/or induced for the survival of all organisms, including eukaryotic, prokaryotic, and plants, from higher temperature stresses. They are the chape… |
| Reversible | Mittal et al · Bioelectrochemistry | 2020 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu | Curcumin (Cur), the yellow pigment of well-known turmeric (Curcuma longa L.) is effective in multiple cancers including triple negative breast cancer (TNBC). In combination with electrical p… |
| Reversible | Mittal et al · Sci Rep | 2020 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres | Triple negative breast cancer (TNBC) represents 15-20% of the over one million new breast cancer cases occurring each year. TNBC is an aggressive cancer phenotype, with low 5-year survival r… |
| Reversible | Rembiałkowska et al · Applied Sciences | 2020 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electroporation increases the transmembrane transport of molecules. The combination of electric pulses with cytostatic compounds is beneficial for cancer treatment. Doxorubicin (DOX) is a co… |
| Reversible | Sieni · Cancers (Basel) | 2020 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Ekstraselüler Matriks ve Doku İskeletinin Korunması | Gene Electro-Transfer (GET) is a powerful method of DNA delivery with great potential for medical applications. Although GET has been extensively studied in vitro and in vivo, the optimal pa… |
| Reversible | Vera-Tizatl et al · Electromagn Biol Med | 2020 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | In order to establish cancer-type-specific electroporation protocols for breast cancer, electroporation was performed in vitro in two modalities: in-suspension and adhered cells. Electropora… |
| Reversible | Aslam et al · RSC Adv | 2019 | İn Vitro Çalışma | Hücre Kültürü | Transmembran Potansiyel Değişimi, Elektrik Alan Dağılımı ve Modellemesi | Electroporation has offered important biomedical applications in electrochemotherapy, tissue ablation and gene editing recently. Time and computation efficient analytical and numerical model… |
| Reversible | Hoejholt et al · Sci Rep | 2019 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | Calcium electroporation is a novel anti-cancer treatment investigated in clinical trials. We explored cell sensitivity to calcium electroporation and electroporation with bleomycin, using vi… |
| Reversible | Mittal et al · Sci Rep | 2019 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | Due to the lack of the three main receptors, triple negative breast cancer (TNBC) is refractive to standard chemotherapy. Hence, alternate therapies are needed. TNBCs utilize glycolysis, whi… |
| İrreversible | Goswami et al · Bioelectrochemistry | 2017 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Low-level electric fields have been demonstrated to induce spatial re-distribution of cell membrane receptors when applied for minutes or hours. However, there is limited literature on the i… |
| Reversible | Pehlivanova et al · Cancer Cell Int | 2012 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | Background: Recently electroporation using biphasic pulses was successfully applied in clinical developments for treating tumours in humans and animals. We evaluated the effects of electrica… |
| Reversible | Kulbacka et al · Folia Biol (Praha) | 2011 | İn Vitro Çalışma | Hücre Kültürü | – | Phototoxicity of drugs used in cancer photodynamic therapy could be augmented by increased accumulation of a photosensitizer in target cells. The intracellular delivery mode that enhances dr… |
| İrreversible | Neal et al · Ann Biomed Eng | 2009 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Developments in breast cancer therapies show potential for replacing simple and radical mastectomies with less invasive techniques. Localized thermal techniques encounter difficulties, preve… |
| Reversible | Parisi et al · – | 2023 | Ön Baskı | – | – | Breast Angiosarcoma is a rare malignancy, accounting less than 1% of all soft tissue. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS). Despite the… |
| Reversible | Esposito et al · – | 2020 | Ön Baskı | – | Nekroz ve Nekroptoz, Darbe Parametrelerinin Optimizasyonu | Background Electrochemotherapy has been shown to be safe, effective and non-invasive loco-regional treatment for chest wall breast cancer recurrence. Electrochemotherapy is the gold standard… |
| Reversible | Łapińska et al · Adv Clin Exp Med | 2022 | Editöryal / Mektup | İnsan | – | Breast cancer (BC) is the most common cancer in women, and its incidence is increasing every year. Current treatment is based on surgical resection, chemotherapy (CT), radiotherapy, and horm… |
| Reversible | Di Meo et al · J Eur Acad Dermatol Venereol | 2019 | Editöryal / Mektup | İnsan | – | N/A |
| Reversible | Campana et al · Breast Cancer Res Treat | 2017 | Editöryal / Mektup | İnsan | – | Breast Cancer Res Treat (2017) 163:403–405 DOI 10.1007/s10549-017-4187-7 REBUTTAL LETTER Effective treatment of intractable cutaneous metastases of breast cancer with electrochemotherapy: a … |
| Reversible | Bosnjak et al · Bioelectrochemistry | 2021 | Düzeltme / Erratum | Hayvan (İn Vivo) | – | Bioelectrochemistry 141 (2021) 107865 Contents lists available at ScienceDirect Bioelectrochemistry journal homepage: www.elsevier.com/locate/bioelechem Corrigendum Corrigendum to ‘‘PARP inh… |
| Reversible | Mittal et al · Sci Rep | 2019 | Düzeltme / Erratum | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması | An amendment to this paper has been published and can be accessed via a link at the top of the paper. |
| Reversible | Zheng et al · Gland Surg | 2012 | Belirtilmemiş | – | – | Luca G. Campana, MD, PhD, Sarcoma and Melanoma Unit, Veneto Region Oncology Research Institute (IOVIRCCS) (Figure 1). |
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