Grup: Deri ve Yüzeyel Tümörler
Malign Melanom
Bu portalın korpusunda melanomun deri ve deri altı metastazları, elektrokemoterapi açısından en yoğun yayın bulunan tekil tümör tipidir. Cerrahiye uygun olmayan, çok sayıda ve tekrarlayan lezyonlarda lokal kontrol amacıyla literatürde çalışılmıştır. Güncel araştırmalarda elektrokemoterapinin immün kontrol noktası inhibitörleriyle kombinasyonunun lokal ve sistemik tümör yanıtları üzerindeki etkisi incelenmektedir.
193yayın kaydıtekilleştirildiğinde 190 bağımsız çalışma
78klinik yayın kaydı
75preklinik yayın kaydı
30derleme
1995–2026yayın aralığı
Klinik yayın: randomize, prospektif ve retrospektif çalışma, vaka serisi ve vaka raporu. Preklinik yayın: hayvan, in vitro, modelleme ve deneysel biyofizik çalışmaları.
Yayınların Bildirdiği Klinik ve Teknik Veriler
Bu alandaki 193 yayının 190 tanesinde tam metinde bildirilen alanların toplamı. Sayılar toplanır, yorumlanmaz.
Yayınlarda bildirilen hasta sayılarının toplamı6.233 (83 yayında bildirilmiş)
Kohortu başka yayınlarla ilişkilendiren yayınkohort örtüşmesi olabilir (3) · aynı kohort (1)
Bildirilen toplam lezyon20.168 (56 yayında)
Kullanılan cihazlar (cihaz adı bildiren 107 yayın)Cliniporator (43) · BTX ECM830 (8) · GT-01 (7) · ELECTRO CELL B10 (6) · Jouan GHT 1287 (3) · MedPulser (3)
Taşınan ajan ve yol (ajan bildiren 161 yayın)bleomisin · intravenöz (63) · plazmid DNA · intratümöral (21) · bleomisin (21) · bleomisin · intratümöral (13) · bleomisin · hem intravenöz hem intratümöral (10) · plazmid DNA (5)
Erişim yolu (105 yayın bildiriyor)perkütan (62) · yüzeyel transkutanöz (39) · intraoperatif (2) · endoskopik (1) · açık cerrahi (1)
Görüntüleme kılavuzluğu (70 yayın bildiriyor)doğrudan görüş (53) · ultrason (14) · bilgisayarlı tomografi (4) · PET-BT (3) · endoskopi (2)
Yanıt ölçütü (84 yayın bildiriyor)klinik muayene (31) · diğer (14) · RECIST (14) · WHO ölçütleri (9) · RECIST 1.1 (7)
Kombinasyon tedavisi (113 yayın bildiriyor)sistemik kemoterapi (38) · diğer immünoterapi (34) · diğer kombinasyon (32) · kontrol noktası inhibitörü (22) · radyoterapi (10)
Tekrar tedavi bildiren yayın67 / 136 yayın (54 yayın bu bilgiyi bildirmiyor)
Alan şiddeti40–12600 V/cm (82 kayıt, ortanca 1125)
Uygulanan gerilim240–3000 V (18 kayıt, ortanca 910)
Darbe sayısı1–480 (99 kayıt, ortanca 8)
Darbe süresi0.4–100000 µs (103 kayıt, ortanca 100)
Toplamlar benzersiz hasta sayısı değildir: aynı kohort birden fazla yayında raporlanmış olabilir.
Yönteme Göre Literatür Durumu
Klinik yöntem başına yayın sayısı, klinik ve preklinik dağılım, literatür hacmi ve yayın aralığı. Sayfa girişindeki rozet yalnızca ECT kaydını özetler; yöntem ayrımının tamamı buradadır.
Elektrokemoterapi (ECT)
124yayın kaydı
69klinik yayın kaydı
27preklinik yayın kaydı
Sınırlı klinik yayın hacmieşik 18/124 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 7, preklinik 6.
1996–2026
İrreversible elektroporasyon (IRE)
6yayın kaydı
0klinik yayın kaydı
5preklinik yayın kaydı
Keşifsel / düşük hacimli literatüreşik 0/6 kayıt
Bu yöntemin hiçbir kaydı hacim etiketine girmemiştir.
2013–2025
Kalsiyum elektroporasyonu
8yayın kaydı
3klinik yayın kaydı
5preklinik yayın kaydı
Keşifsel / düşük hacimli literatüreşik 0/8 kayıt
Bu yöntemin hiçbir kaydı hacim etiketine girmemiştir.
2017–2024
Gen elektrotransferi
24yayın kaydı
1klinik yayın kaydı
22preklinik yayın kaydı
Keşifsel / düşük hacimli literatüreşik 0/24 kayıt
Bu yöntemin hiçbir kaydı hacim etiketine girmemiştir.
2008–2025
Diğer elektroporasyon uygulamaları
31yayın kaydı
5klinik yayın kaydı
16preklinik yayın kaydı
Bu küme tek bir klinik yöntemi adlandırmaz; literatür hacmi atanmaz.
1995–2025
Özetlerde Anılan Mekanizmalar
Rakam, mekanizma adının geçtiği özet sayısıdır. Bir mekanizmanın anılması, o çalışmada gösterildiği anlamına gelmez.
Bleomisin Hücre İçi Birikiminin Artması 59
Gen Elektrotransferi (Plazmid DNA) 33
İnterlökin-12 Aracılı İmmün Uyarım 23
İmmün Kontrol Noktası İnhibitörü Kombinasyonu 23
Reversible Membran Permeabilizasyonu 22
Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu 19
Sisplatin Hücre İçi Birikiminin Artması 17
Nekroz ve Nekroptoz 17
Apoptoz İndüksiyonu 16
Sistemik / Abskopal İmmün Yanıt 15
Darbe Parametrelerinin Optimizasyonu 13
Kas Kasılması ve Anestezi Gereksinimi 10
Çalışma Tipi Dağılımı
Yüzde, alanın tamamındaki payı verir.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Randomize Klinik Çalışma | 2 | %1 |
| Prospektif Klinik Çalışma | 3 | %2 |
| Klinik Çalışma | 37 | %19 |
| Retrospektif Klinik Çalışma | 11 | %6 |
| Vaka Serisi | 3 | %2 |
| Vaka Raporu | 22 | %11 |
| Sistematik Derleme / Meta-Analiz | 4 | %2 |
| Kılavuz / Uzlaşı | 2 | %1 |
| Derleme | 26 | %13 |
| Hayvan Çalışması | 54 | %28 |
| İn Vitro Çalışma | 20 | %10 |
| Deneysel Biyofizik Çalışması | 1 | <%1 |
| Anket / Saha Araştırması | 1 | <%1 |
| Kongre Özeti | 1 | <%1 |
| Editöryal / Mektup | 5 | %3 |
| Düzeltme / Erratum | 1 | <%1 |
Yayın Tablosu
193 yayın kaydı, çalışma tasarımına göre sıralanmıştır. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
Sınıflandırmalar otomatik üretilir ve tekil kayıtlarda hata içerebilir. Metodoloji
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Hasta / lezyon | Cihaz | Ajan ve yol | Bildirilen sonuç | Özet |
|---|---|---|---|---|---|---|---|---|---|---|
| ECT | Gaudy et al · J Cutan Med Surg | 2006 | Randomize Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 12 / 54 | MedPulser | bleomisin · intratümöral | – | Background: Electrochemotherapy (ECT) combines intralesional injections of bleomycin with electroporation (EP), which permeabilizes tumor cells and thus increases the bleomycin efficacy at t… |
| ECT | Byrne et al · Melanoma Res | 2005 | Randomize Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 19 / 18 | MedPulser | bleomisin · intratümöral | nesnel yanıt 78% (18 lezyon) | Electroporation therapy (EPT) is a novel treatment modality that uses brief, high-intensity, pulsed electrical currents to enhance the uptake of chemotherapeutic agents, vaccines and genes i… |
| ECT | Rózsa et al · Dermatologic Therapy | 2025 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 44 / 339 | Cliniporator | bleomisin · intravenöz | nesnel yanıt 71% (82 lezyon) | Introduction: Immunosuppressed patients face a significantly higher risk of developing malignant skin tumors compared to the general population, often presenting with numerous, rapidly growi… |
| Diğer EP | Theurich et al · Cancer Immunol Res | 2016 | Prospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sistemik / Abskopal İmmün Yanıt | 127 / 137 | – | – | nesnel yanıt 0.378 oran (45 hasta) | Immune checkpoint inhibition with ipilimumab has revolutionized cancer immunotherapy and significantly improved outcomes of patients with advanced malignant melanoma. Local peripheral treatm… |
| ECT | Simeone et al · J Transl Med | 2014 | Prospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sistemik / Abskopal İmmün Yanıt | 15 | – | bleomisin | tam yanıt 4 adet (10 hasta) | Ipilimumab is the first agent approved for the treatment of advanced melanoma that showed a survival benefit in randomized phase 3 trials. Despite the survival benefit, due to its mechanism … |
| ECT | Kempa-Kamińska et al · EJC Skin Cancer | 2026 | Klinik Çalışma | İnsan | – | 1 | – | bleomisin · intravenöz | – | Bu yayında özet bulunmuyor. |
| ECT | Kis et al · Clin Exp Metastasis | 2025 | Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 170 | square wave electric pulse generator | bleomisin · hem intravenöz hem intratümöral | – | Published data on the combination of immunotherapy and electrochemotherapy (ECT) consistently indicate a benefit in tumor response, but an important question, the optimal timing for combinat… |
| ECT | Caballero-Borrego et al · Braz J Otorhinolaryngol | 2024 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 56 | – | bleomisin · intravenöz | nesnel yanıt 84% (56 hasta) | Objectives: To evaluate the efficacy and tolerance after the electrochemotherapy treatment for local therapy of cutaneous and subcutaneous metastases of head-and-neck tumors and malignant me… |
| Kalsiyum EP | Vissing · Acta Oncol | 2024 | Klinik Çalışma | İnsan | Nekroz ve Nekroptoz, Sistemik / Abskopal İmmün Yanıt | 17 / 49 | Cliniporator | kalsiyum klorür · intratümöral | nesnel yanıt 58.6% (29 lezyon) | Background and purpose: Calcium electroporation (CaEP) involves injecting calcium into tumour tissues and using electrical pulses to create membrane pores that induce cell death. This study … |
| ECT | Ziętek et al · Postepy Dermatol Alergol | 2022 | Klinik Çalışma | İnsan | – | 5 / 200 | Cliniporator, EPS02 | bleomisin · intravenöz | nesnel yanıt 66.7 ay (5 hasta) | Introduction: Patients with cutaneous malignant melanoma (MM), in case of non-resectability of the lesions, have only a limited pool of the available treatment options. In recent years espec… |
| ECT | Sersa et al · European Journal of Surgical Oncology | 2021 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 61 | – | bleomisin · hem intravenöz hem intratümöral | tam yanıt 57.4% (61 hasta) | While the risks associated with sentinel lymph node (SLN) biopsy in the regional nodal staging for malignant melanoma are low, efforts have been made at identifying patients in whom the proc… |
| ECT | Pirc et al · Clin Ther | 2020 | Klinik Çalışma | İnsan | – | 23 | Cliniporator | bleomisin · intravenöz | yaşam kalitesi 0.29 skor (23 hasta) | Purpose: Electrochemotherapy is increasingly entering into national and international guidelines, requiring formal evaluation of treatment costs and cost-effectiveness to ensure that its upt… |
| Diğer EP | Ascierto et al · J Transl Med | 2020 | Klinik Çalışma | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 376 | – | bleomisin | genel sağkalım 88% (376 hasta) | The melanoma treatment landscape changed in 2011 with the approval of the first anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 checkpoint inhibitor and of the first BRAF-targeted mo… |
| ECT | Jamsek et al · Radiol Oncol | 2020 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | 28 / 52 | Cliniporator | bleomisin · intravenöz | tam yanıt 100% (24 lezyon) | Background Electrochemotherapy (ECT) is a local cancer treatment based on electroporation where the electric field is used to enhance cell membrane permeability and thereby facilitating the … |
| ECT | Odili et al · European Journal of Surgical Oncology | 2019 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | 246 / 679 | – | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 80% (203 hasta) | Basal cell carcinoma(BCC) is one of the most common skin malignancies worldwide. In comparison to current management strategies for BCC, electrochemotherapy (ECT) proved to be a valid altern… |
| ECT | Kunte et al · Br J Dermatol | 2017 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | 114 / 394 | IGEA electroporator | bleomisin · intravenöz | genel sağkalım 67% (114 hasta) | Background: (ECT) is an effective local treatment for cutaneous metastasis. Treatment involves the administration of chemotherapeutic drugs followed by delivery of electrical pulses to the t… |
| ECT | Bigi et al · Clin Cosmet Investig Dermatol | 2016 | Klinik Çalışma | İnsan | Apoptoz İndüksiyonu, Nekroz ve Nekroptoz | 2 / 21 | Cliniporator | bleomisin · intravenöz | progresif hastalık 0 adet (2 hasta) | Background: Electrochemotherapy (ECT) is increasingly used in the treatment of primary and secondary skin tumors, but little is known about the pathologic mechanism responsible for tumor cel… |
| ECT | Di Gennaro et al · Clin Exp Metastasis | 2016 | Klinik Çalışma | İnsan | İmmünojenik Hücre Ölümü (ICD) | – | – | bleomisin | – | Electrochemotherapy (ECT) represents an effective local treatment for skin unresectable melanoma metastases with high overall objective response rate. ECT is based on the combination of anti… |
| ECT | Grau et al · Braz J Otorhinolaryngol | 2016 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | – | Cliniporator | bleomisin · intravenöz | – | Introduction: Local progression of papillary thyroid carcinoma (PTC) after failure of standard therapies may cause pain, ulceration, and bleeding. As patients are fully aware of the tumor gr… |
| ECT | Mir-Bonafé et al · Actas Dermosifiliogr | 2015 | Klinik Çalışma | İnsan | Nekroz ve Nekroptoz | 31 | Cliniporator | bleomisin · intravenöz | tam yanıt 23% (31 hasta) | Introduction and objectives: Electrochemotherapy is indicated for the treatment of unresectable cutaneous and subcutaneous tumors. The technique involves the synergistic use of electroporati… |
| Diğer EP | Bhatia et al · European Journal of Cancer | 2015 | Klinik Çalışma | İnsan | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · intratümöral | – | Interleukin-12 (IL-12), a master regulator of adaptive type-1 immunity, has demonstrated antitumor efficacy, but is associated with severe toxicities when administered systemically. Local IL-… |
| ECT | Caracò et al · Melanoma Manag | 2015 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 89 | Cliniporator | bleomisin · intravenöz | nesnel yanıt 67.5% (89 hasta) | Aim: This study was undertaken to update the outcome of the treated lesions with electrochemotherapy (ECT) plus intravenous injection of bleomycin in patients with in-transit disease or dist… |
| ECT | Mir-Bonafé et al · Actas Dermo-Sifiliográficas (English Edition) | 2015 | Klinik Çalışma | İnsan | Nekroz ve Nekroptoz | 31 | Cliniporator | bleomisin · intravenöz | tam yanıt 23% (31 hasta) | Electrochemotherapy is indicated for the treatment of unresectable cutaneous and subcutaneous tumors. The technique involves the synergistic use of electroporation of cell membranes to incre… |
| ECT | Mozzillo et al · J Transl Med | 2014 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 60 | – | bleomisin · intravenöz | nesnel yanıt 86.6% (60 hasta) | Background Treatment of early and multiple cutaneous unresectable recurrences is a major therapeutic problem with around 80% of patients relapsing within 5 years [1]. For lesions refractory … |
| ECT | Caracò et al · BMC Cancer | 2013 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 60 | Cliniporator | bleomisin · intravenöz | nesnel yanıt 86.6% (60 hasta) | Background: Treatment of early and multiple cutaneous unresectable recurrences is a major therapeutic problem with around 80% of patients relapsing within 5 years. For lesions refractory to … |
| ECT | Ricotti et al · Dermatol Ther | 2013 | Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 30 / 654 | Cliniporator | bleomisin · intravenöz | nesnel yanıt 100% (654 lezyon) | Treatment of multiple cutaneous and subcutaneous melanoma metastases is still represents a therapeutic challenge for both dermatologists and oncologists. Electrochemotherapy (ECT) is a promi… |
| ECT | Campana et al · Br J Surg | 2012 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 85 / 894 | Cliniporator | bleomisin · hem intravenöz hem intratümöral | tam yanıt 48.1% (268 lezyon) | Background: The aim of the study was to determine predictive factors for effectiveness, toxicity and local disease control in patients with malignant melanoma treated with bleomycin-based el… |
| ECT | Di Monta et al · European Journal of Surgical Oncology (EJSO) | 2012 | Klinik Çalışma | İnsan | – | 1 / 1 | – | bleomisin | tam yanıt 3 skor (2 seans) | Bu yayında özet bulunmuyor. |
| ECT | Mozzillo et al · European Journal of Surgical Oncology (EJSO) | 2012 | Klinik Çalışma | İnsan | – | 1 / 1 | – | bleomisin · intravenöz | – | Bu yayında özet bulunmuyor. |
| ECT | Farricha et al · Melanoma Research | 2010 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 113 | – | bleomisin | – | Introduction We started to perform Electrochemotherapy (ECT) in Lisbon since February 2008. We initially treated mainly Melanoma patients but with the growing knowledge on this technique we … |
| ECT | Kyrgias et al · Melanoma Research | 2010 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 44 | – | – | – | Introduction ECT is based on the local delivery of electric pulses that causes transient permeabilisation of the cell membrane, facilitating the intracellular delivery of chemotherapeutic dr… |
| Diğer EP | Bonehill et al · Clin Cancer Res | 2009 | Klinik Çalışma | İnsan | – | – | – | – | – | Purpose: A critical factor determining the effectiveness of currently used dendritic cell (DC)-based vaccines is the DC activation or maturation status. We have recently shown that the T-cel… |
| ECT | Campana et al · Ann Surg Oncol | 2009 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | 52 / 608 | Cliniporator | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 96% (52 hasta) | Electrochemotherapy (ECT) has emerged as a complementary treatment for superficial metastases. Fifty-two consecutive patients with different cancer histotypes, mainly melanoma and breast can… |
| Diğer EP | Tauceri et al · Langenbecks Arch Surg | 2008 | Klinik Çalışma | İnsan | – | 84 | Cliniporator | bleomisin · intratümöral | genel sağkalım 72.1% (84 hasta) | Background and aims: Survival rates of patients with stage IV melanoma are poor: Median survival is 7-8 months and 5-year survival rates about 5%. There is no agreement on the role of surger… |
| Gen ET | Daud et al · J Clin Oncol | 2008 | Klinik Çalışma | İnsan | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | 24 | MedPulser | plazmid DNA · intratümöral | tam yanıt 2 adet (19 hasta) | Purpose: Gene-based immunotherapy for cancer is limited by the lack of safe, efficient, reproducible, and titratable delivery methods. Direct injection of DNA into tissue, although safer tha… |
| ECT | Quaglino et al · Ann Surg Oncol | 2008 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 14 / 233 | – | bleomisin · intravenöz | – | Background: Electrochemotherapy (ECT) combines chemotherapy and electroporation to increase drug uptake. Its role in cutaneous melanoma metastasis treatment is not well defined; indeed, few … |
| ECT | Gehl et al · Melanoma Res | 2000 | Klinik Çalışma | İnsan | Hemostaz ve Kanama Kontrolü, Bleomisin Hücre İçi Birikiminin Artması | 1 / 9 | BTX T820 square wave electroporator | bleomisin · intratümöral | tam yanıt 100% (9 lezyon) | Electric pulses can cause transient permeabilization of cell membranes (electroporation) and this can be utilized to increase the uptake of chemotherapy (electrochemotherapy). Preclinical st… |
| ECT | Rols et al · Melanoma Res | 2000 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 4 / 55 | PS 15 | bleomisin · intravenöz | nesnel yanıt 90% (55 lezyon) | Electrochemotherapy is a new anticancer therapy in which transient permeabilization of cells by an electric field induces a significant increase in the bleomycin concentration and toxicity i… |
| ECT | Sersa et al · Clin Cancer Res | 2000 | Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 10 / 133 | Jouan GHT 1287 | sisplatin · intratümöral | nesnel yanıt 78% (82 lezyon) | Electrochemotherapy consists of chemotherapy followed by local application of electric pulses to the tumor to increase drug delivery into the cells. The aim of this Phase II clinical study w… |
| ECT | Serša et al · Melanoma Res | 2000 | Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Jouan GHT 1287 | sisplatin | – | The application of electric pulses to skin tumour nodules enhances the antitumour effectiveness of cisplatin. This treatment approach, known as electrochemotherapy, was employed in the treat… |
| ECT | Heller et al · Melanoma Research | 1997 | Klinik Çalışma | İnsan | – | – | – | – | – | Heller, R; Jaroszeski, M; DeConti, R; Reintgen, D; Gilbert, R; Glass, F Author Information |
| ECT | Glass · Arch Dermatol | 1996 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | 5 / 23 | T820 Electro Square Porator | bleomisin · intratümöral | tam yanıt 78% (23 lezyon) | Background Electroporation is a new technique that enhances the antitumor effects of chemotherapy by exposing cancerous tissues to pulses of electricity. When used in combination with conven… |
| ECT | Campana et al · Eur J Surg Oncol | 2025 | Retrospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 452 | – | bleomisin · intravenöz | nesnel yanıt 63% (452 hasta) | Background: This study analysed treatment strategies with electrochemotherapy (ECT) in melanoma with limb in-transit metastases (ITM). Methods: We audited AJCC v.8 stage IIIB-IIID patients t… |
| ECT | Siegmund et al · Cancers (Basel) | 2025 | Retrospektif Klinik Çalışma | İnsan | – | 11 / 66 | – | bleomisin · intravenöz | – | Background/Objectives : Electrochemotherapy (ECT) has emerged as a promising locoregional treatment modality for patients with cutaneous and subcutaneous melanoma metastases. While systemic … |
| ECT | Campana et al · European Journal of Surgical Oncology | 2024 | Retrospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sistemik / Abskopal İmmün Yanıt | 452 | – | bleomisin · intravenöz | nesnel yanıt 64% (452 hasta) | Adjuvant BRAF/MEK inhibitors and immunotherapy with anti-PD-1 have become the standard of care for resected high-risk stage III and IV melanoma, but a head-to-head comparison in a clinical t… |
| ECT | Zdzienicki et al · J Clin Med | 2024 | Retrospektif Klinik Çalışma | İnsan | – | 88 | – | bleomisin · intravenöz | tam yanıt 45% (88 hasta) | Background/Objectives : Despite observing progress in recent years in the treatment of patients with advanced melanoma, the optimal management of locoregional recurrence has not been determi… |
| ECT | Campana et al · Cancers (Basel) | 2021 | Retrospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, İmmünojenik Hücre Ölümü (ICD) | 130 | – | bleomisin · hem intravenöz hem intratümöral | lokal kontrol 86% | Electrochemotherapy (ECT) is an effective locoregional therapy for cutaneous melanoma metastases and has been safely combined with immune checkpoint inhibitors in preliminary experiences. Si… |
| ECT | Guida et al · Cancers (Basel) | 2019 | Retrospektif Klinik Çalışma | İnsan | – | 27 | – | bleomisin · intravenöz | genel sağkalım 38 ay (27 hasta) | Background : A limited degree of progression after a response to treatment is labelled as oligoprogression and is a hot topic of metastatic melanoma (MM) management. Rogue progressive metast… |
| ECT | Heppt et al · Cancer Immunol Immunother | 2016 | Retrospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 33 | Cliniporator, SENNEX | bleomisin · intravenöz | lokal kontrol 75.8% (33 hasta) | Growing evidence suggests that concurrent loco-regional and systemic treatment modalities may lead to synergistic anti-tumor effects in advanced melanoma. In this retrospective multicenter s… |
| ECT | Hribernik et al · Radiol Oncol | 2016 | Retrospektif Klinik Çalışma | İnsan | – | 5 | Cliniporator | bleomisin · intravenöz | tam yanıt 85% (118 lezyon) | Background: The combination of electrochemotherapy with immuno-modulatory treatments has already been explored and proven effective. However, the role of interferon alpha (IFN-α) adjuvant th… |
| ECT | Mozzillo et al · Oncoimmunology | 2015 | Retrospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Melanoma is responsible for most skin cancer-related deaths and is one of the most common cancers diagnosed in young adults. In melanoma, tumors can become established by activation of the n… |
| ECT | Solivetti et al · J Exp Clin Cancer Res | 2014 | Retrospektif Klinik Çalışma | İnsan | – | 15 / 52 | – | – | – | Background: Over the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival … |
| ECT | Testori et al · European Journal of Surgical Oncology | 2012 | Retrospektif Klinik Çalışma | İnsan | – | – | – | – | – | Bu yayında özet bulunmuyor. |
| ECT | YazdanParast et al · Technol Cancer Res Treat | 2025 | Vaka Serisi | İnsan | – | 26 / 104 | OncoPore | bleomisin · intravenöz | tümör hacmi değişimi 100 adet (26 hasta) | PurposeThis study aimed to investigate the efficacy of electrochemotherapy on the three common types of skin cancer, including basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (… |
| ECT | Carrera et al · J Eur Acad Dermatol Venereol | 2013 | Vaka Serisi | İnsan | – | 8 | – | bleomisin · intravenöz | lokal kontrol 2 adet (2 hasta) | Background: Desmoplastic malignant melanoma (DMM) is a rare and usually misdiagnosed type of melanoma. Delayed detection at complicated anatomical locations can lead to the necessity of alte… |
| ECT | Kis et al · Dermatologic Surgery | 2011 | Vaka Serisi | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | 9 / 158 | Cliniporator | bleomisin · intravenöz | nesnel yanıt 62% (158 lezyon) | OBJECTIVES Electrochemotherapy (ECT) is a novel therapeutic option for the treatment of cutaneous and subcutaneous metastases of malignant melanoma. During the treatment, electric pulses are… |
| ECT | Rózsa et al · J Dermatolog Treat | 2025 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – / 2482 | Cliniporator | bleomisin · intravenöz | – | Purpose: Lentigo maligna (LM), lentigo maligna melanoma (LMM), and acral lentiginous melanoma (ALM) are characterized by irregular borders and manifest on highly visible and/or surgically ch… |
| ECT | Carpenè et al · Eur Arch Otorhinolaryngol | 2024 | Vaka Raporu | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 1 / 1 | – | bleomisin · intravenöz | genel sağkalım 17 ay (1 hasta) | Background: Sinonasal Mucosal Melanoma (SNMM) is a rare but aggressive disease. Surgery with free margins, when feasible, is the treatment of choice. In the last three decades, electrochemot… |
| ECT | Morgese et al · Mol Clin Oncol | 2023 | Vaka Raporu | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 1 | – | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Immune checkpoint inhibitors have changed the natural history of advanced melanoma. Despite this, a notable proportion of patients immediately relapse or develop resistance during immunother… |
| Kalsiyum EP | Vissing et al · Acta Oncol | 2023 | Vaka Raporu | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 1 / 1 | Cliniporator | kalsiyum klorür · intratümöral | tam yanıt 1 adet (1 hasta) | Calcium electroporation (CaEP) has demonstrated promising results for local treatment of cutaneous metastases from breast cancer, melanoma, and head-and-neck cancer in initial clinical trial… |
| ECT | Landström et al · Melanoma Manag | 2022 | Vaka Raporu | İnsan | – | 1 / 1 | SENNEX | sisplatin · intratümöral | – | Despite the progress in immunotherapy and targeted therapy for patients with cutaneous malignant melanoma not all patients with loco-regional recurrences will respond to treatment. Electroch… |
| ECT | Russano et al · Oncol Lett | 2022 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 | Cliniporator | bleomisin · intravenöz | – | The Buschke-Löwenstein tumor (BLT), also known as giant condyloma acuminatum, is a rare sexually transmitted disease often associated with human papillomavirus types 6 and 11. There are no s… |
| ECT | Quaresmini et al · Front Oncol | 2021 | Vaka Raporu | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 1 | Cliniporator | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Background: Immunotherapy with immune checkpoint inhibitors is one of the main therapies for advanced melanoma. Nevertheless, albeit remarkable, immunotherapy results are still unsatisfactor… |
| ECT | Gallagher et al · JPRAS Open | 2020 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | 2 | – | bleomisin | – | Bleomycin electrochemotherapy (ECT) has emerged as a treatment modality for locally advanced metastatic melanoma over the past decade. The phenomenon of reversible electroporation enhances c… |
| ECT | Saad et al · Eur J Plast Surg | 2020 | Vaka Raporu | İnsan | – | 1 / 1 | – | bleomisin | kanama kontrolü 3 gün (1 hasta) | The management of sinister cutaneous lesions including malignant melanoma in the clinically frail patient tends to present clinicians with a professional and ethical dilemma on the optimal b… |
| ECT | Karaca et al · Anticancer Drugs | 2018 | Vaka Raporu | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 1 / 1 | IGEA Cliniprator, Cliniporator | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Metastatic melanoma (MM) is one of the most lethal types of cancer. Although novel immunotherapeutics have been developed recently, still, these drugs fail to save the lives of a third of MM… |
| Kalsiyum EP | Falk et al · Acta Oncol | 2017 | Vaka Raporu | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Sistemik / Abskopal İmmün Yanıt | 1 / 100 | Cliniporator | bleomisin · intravenöz | tam yanıt 1 oran (1 hasta) | In this case study, we report a remarkable systemic response after treatment with electrochemotherapy and calcium electroporation in a patient with disseminated malignant melanoma.Electroche… |
| ECT | Brizio et al · Eur J Dermatol | 2015 | Vaka Raporu | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Nekroz ve Nekroptoz | 1 / 28 | Cliniporator | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Skin metastases represent a relatively frequent event in the natural history of melanoma, developing both in early and in late disease stages. Cutaneous or subcutaneous lesions arise in 15-2… |
| ECT | Valpione et al · Radiol Oncol | 2015 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 / 3 | – | bleomisin · intravenöz | lokal kontrol 1 adet (1 hasta) | Background: Small molecules that inhibit V600 mutated BRAF protein, such as vemurafenib and dabrafenib, are effective in treatment of metastatic melanoma. Case report: We here describe the c… |
| ECT | Gasbarrini et al · Spine (Phila Pa 1976) | 2015 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | 1 / 1 | Cliniporator VITAE | bleomisin · intravenöz | nesnel yanıt 1% (1 hasta) | Study design: Preliminary report of new antitumor treatment. Objective: To evaluate the effectiveness of electrochemotherapy as a novel treatment of spinal metastasis. Summary of background … |
| ECT | Mozzillo et al · J Transl Med | 2012 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 1 / 1 | – | bleomisin · intravenöz | tam yanıt 1 adet (1 lezyon) | Background: Approximately 200,000 new cases of melanoma are diagnosed worldwide each year. Skin metastases are a frequent event, occurring in 18.2% of cases. This can be distressing for the … |
| ECT | Miklavcic et al · Biomed Eng Online | 2010 | Vaka Raporu | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | 1 / 1 | Cliniporator VITAE | bleomisin · intravenöz | kısmi yanıt 50% (1 hasta) | Background: Electrochemotherapy treats tumors by combining specific chemotherapeutic drugs with an intracellular target and electric pulses, which increases drug uptake into the tumor cells.… |
| ECT | Snoj et al · Tumori | 2009 | Vaka Raporu | İnsan | Elektrot Geometrisi ve Yerleşimi, Bleomisin Hücre İçi Birikiminin Artması | 1 / 1 | – | bleomisin · intravenöz | kanama kontrolü 1 adet (1 hasta) | Aims and background: Electrochemotherapy is an effective local treatment for tumors that combines administration of a chemotherapeutic drug with the subsequent application of electric pulses… |
| ECT | Snoj et al · Croat Med J | 2007 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | 1 / 224 | Cliniporator | bleomisin · intravenöz | tam yanıt 100% (42 lezyon) | Multiple unresectable melanoma skin metastases pose a treatment problem, especially in centers where isolated limb perfusion is not available. We report the case of a 59-year-old woman who d… |
| ECT | Gehl et al · European Journal of Cancer Supplements | 2006 | Vaka Raporu | İnsan | Hemostaz ve Kanama Kontrolü | 1 / 8 | – | bleomisin · intravenöz | tam yanıt 7 oran (8 lezyon) | Increasing emphasis is being put on palliation of terminally ill cancer patients. Bleeding skin metastases are one of the many grievances that may negatively affect quality of life. In the s… |
| ECT | Snoj et al · European Journal of Cancer Supplements | 2006 | Vaka Raporu | İnsan | Sisplatin Hücre İçi Birikiminin Artması | 1 / 16 | Jouan GHT 1287 | sisplatin · intratümöral | tam yanıt 100% (16 lezyon) | The optimal treatment of multiple cutaneous and subcutaneous metastases of melanoma still remains unresolved. There are many different possible treatment modalities. We present a case of mel… |
| ECT | Kubota et al · Melanoma Res | 2005 | Vaka Raporu | İnsan | – | 1 / 8 | – | bleomisin · intratümöral | tam yanıt 3 adet (3 lezyon) | Kubota, Yoko; Tomita, Yoshihiko; Tsukigi, Masaaki; Kurachi, Hirohisa; Motoyama, Teiichi; Mir, Lluis M. Author Information |
| ECT | Snoj et al · Anticancer Drugs | 2005 | Vaka Raporu | İnsan | Sisplatin Hücre İçi Birikiminin Artması | 1 / 1 | Cliniporator | sisplatin · intratümöral | tümör hacmi değişimi 3.8 cm³ | Anorectal malignant melanoma is a rare tumor and there is no consensus on whether aggressive or local management is more appropriate. Local sphincter-saving excision has been shown to have a… |
| ECT | Vickars et al · Cureus | 2025 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | – / 2482 | – | bleomisin | – | Electrochemotherapy (ECT) is a locoregional cancer treatment primarily used in the palliative management of cutaneous metastases from malignant melanoma. However, its clinical effectiveness,… |
| ECT | Milicevic et al · Int J Mol Sci | 2023 | Sistematik Derleme / Meta-Analiz | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 1 | – | bleomisin · intravenöz | tam yanıt 1 adet (1 hasta) | Cutaneous melanoma is a highly aggressive form of skin cancer. The development of immune checkpoint inhibitors (ICIs) has revolutionized the management of advanced melanoma, led to durable r… |
| ECT | Ferioli et al · Clin Exp Metastasis | 2022 | Sistematik Derleme / Meta-Analiz | İnsan | Nekroz ve Nekroptoz | 529 / 2987 | – | – | genel sağkalım 80.6% | The main treatment of MM metastases are systemic therapies, surgery, limb perfusion, and intralesional talimogene laherparepvec. Electrochemotherapy (ECT) is potentially useful also due to t… |
| ECT | Aguado-Romeo et al · Actas Dermosifiliogr | 2017 | Sistematik Derleme / Meta-Analiz | İnsan | – | – | – | bleomisin · intravenöz | nesnel yanıt 60.2% (915 hasta) | Electrochemotherapy is a therapeutic option for the treatment of cutaneous and subcutaneous metastases from melanoma and other tumors. The procedure consists of the administration of antican… |
| ECT | Campana et al · Br J Surg | 2023 | Kılavuz / Uzlaşı | İnsan | – | 987 / 2482 | – | bleomisin | – | Background Skin metastases are an important co-morbidity in melanoma. Despite broad adoption, electrochemotherapy implementation is hindered by a lack of treatment indications, uncertainty r… |
| ECT | Campana et al · European Journal of Surgical Oncology | 2019 | Kılavuz / Uzlaşı | İnsan | – | – | – | – | – | Electrochemotherapy (ECT) has evolved considerably over the past decade, but its application is yet to be standardized. In fact, a lack of agreement exists on eligible patients, timing of tr… |
| Gen ET | Ahmad et al · J Clin Med | 2024 | Derleme | Literatür Analizi | İnterlökin-12 Aracılı İmmün Uyarım, Sistemik / Abskopal İmmün Yanıt | 987 / 2482 | – | – | – | Electroporation with chemotherapy (ECT) is currently offered as a treatment in Europe for locoregional or metastatic melanoma with cutaneous lesions. However, the role of surgery and other f… |
| Diğer EP | Criado-Otero et al · Cancers (Basel) | 2024 | Derleme | Literatür Analizi | İnterlökin-12 Aracılı İmmün Uyarım, Sistemik / Abskopal İmmün Yanıt | – | – | diğer · hem intravenöz hem intratümöral | – | Cutaneous melanoma is a malignant neoplasm with local and distant metastatic potential. When feasible, surgery is the first line of treatment in locoregionally advanced disease. Topical and … |
| Diğer EP | Russano et al · Cancers (Basel) | 2024 | Derleme | Literatür Analizi | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | – | – | bleomisin | nesnel yanıt 80% | In-transit metastases (ITM) in melanoma present a significant therapeutic challenge due to their advanced stage and complex clinical nature. From traditional management with surgical resecti… |
| Diğer EP | Corvino et al · J Ultrasound Med | 2022 | Derleme | İnsan | – | – | – | bleomisin · intravenöz | – | Cutaneous melanoma incidence is increasing worldwide, representing an aggressive tumor when evolving to the metastatic phase. High-resolution ultrasound (US) is playing a growing role in the… |
| IRE | Justesen et al · Cancers (Basel) | 2022 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | kalsiyum klorür | – | The discovery of electroporation in 1968 has led to the development of electrochemotherapy (ECT) and irreversible electroporation (IRE). ECT and IRE have been established as treatments of cu… |
| ECT | Vega Díez et al · Actas Dermo-Sifiliográficas | 2022 | Derleme | İnsan | – | – | – | bleomisin · hem intravenöz hem intratümöral | tam yanıt 61% (987 hasta) | ACTAS Dermo-Sifiliográficas 113 (2022) T817---T818 RESIDENT’S FORUM [Translated article] RF----Electrochemotherapy in the Treatment of Primary and Secondary Skin Tumors FR----Electroquimiotera… |
| ECT | Cucu et al · Materials (Basel) | 2021 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 30 / 654 | – | bleomisin · intravenöz | – | Electrochemotherapy (ECT) is an effective bioelectrochemical procedure that uses controlled electrical pulses to facilitate the increase of intracellular concentration of certain substances … |
| Diğer EP | Sagwal et al · Oxid Med Cell Longev | 2021 | Derleme | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | – | – | – | Metabolic energy production naturally generates unwanted products such as reactive oxygen species (ROS), causing oxidative damage. Oxidative damage has been linked to several pathologies, in… |
| Diğer EP | Ascierto · J Transl Med | 2018 | Derleme | Literatür Analizi | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | – | – | – | – | Metastatic melanoma represents a challenging clinical situation and, until relatively recently, there was an absence of effective treatment options. However, in 2011, the advanced melanoma t… |
| ECT | Goggins et al · Int J Dermatol | 2018 | Derleme | İnsan | – | – | – | bleomisin · intravenöz | tam yanıt 50% (52 hasta) | Electrochemotherapy (ECT) is a treatment modality that combines low-dose chemotherapy with electroporation, thereby enhancing cytotoxicity. ECT was first utilized in the treatment of metasta… |
| ECT | Wichtowski et al · Contemp Oncol (Pozn) | 2018 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu | – | – | bleomisin · intravenöz | – | Electrochemotherapy is a new therapeutic option for patients with locally spread melanoma. It is based on the phenomenon of reversible electroporation, i.e. a transient increase in permeabil… |
| ECT | Cerio et al · Br J Dermatol | 2017 | Derleme | İnsan | – | – | – | bleomisin | nesnel yanıt 77% (394 lezyon) | Linked Article: Kunte et al. Br J Dermatol 2017; 176:1475–1485. |
| Diğer EP | Ascierto · J Transl Med | 2017 | Derleme | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 30 | – | bleomisin | – | Major advances have been made in the treatment of cancer with targeted therapy and immunotherapy; several FDA-approved agents with associated improvement of 1-year survival rates became avai… |
| ECT | Campana et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | – | – | – | bleomisin · hem intravenöz hem intratümöral | – | Cutaneous metastases are not unusual in the clinical course of malignant melanoma, occurring in 2–20% of patients, depending on primary tumor features and disease stage. Patients with superfi… |
| ECT | Rutkowski et al · Melanoma Manag | 2014 | Derleme | Literatür Analizi | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sistemik / Abskopal İmmün Yanıt | 34 | – | bleomisin · intravenöz | genel sağkalım 29 adet (34 hasta) | The majority of locoregional relapses of cutaneous melanoma occur as subcutaneous local recurrences/in-transit metastases; subcutaneous metastases (SMs) are also common in distant metastases… |
| ECT | Campana et al · J Surg Oncol | 2013 | Derleme | Hayvan (İn Vivo) | – | – | – | bleomisin · intravenöz | tam yanıt 73.7% (41 hasta) | Superficially metastatic melanoma still represents a challenging situation for oncologists and a distressing condition for patients. In this circumstance, local treatment by electrochemother… |
| ECT | Rastrelli et al · ISRN Dermatol | 2013 | Derleme | İnsan | – | – | – | bleomisin | – | This paper reviews the epidemiology, diagnosis, and treatment of M zero cutaneous melanoma including the most recent developments. This review also examined the main risk factors for melanom… |
| Diğer EP | Wong et al · N Am J Med Sci | 2013 | Derleme | Literatür Analizi | – | – | – | sisplatin | tümör hacmi değişimi 77% | Skin metastases are rare in the routine clinical practice of dermatology, but are of major clinical significance because they usually indicate advanced disease. We reviewed the literature on… |
| ECT | Testori et al · Curr Opin Oncol | 2012 | Derleme | İnsan | – | – | – | bleomisin · intravenöz | tam yanıt 73.7% (102 hasta) | Purpose of review: In the present study, the role of electrochemotherapy (ECT) in the advanced melanoma setting, either as alternative treatment modality to conventional therapies or as pall… |
| ECT | Testori et al · Dermatol Ther | 2012 | Derleme | Literatür Analizi | Sistemik / Abskopal İmmün Yanıt | – | – | bleomisin · hem intravenöz hem intratümöral | – | Nowadays, melanoma is one of the most common fatal malignancy of young adults. Incidence is increasing, but mortality rates from melanoma have remained stable. In-transit metastases from ext… |
| ECT | Good et al · J Am Acad Dermatol | 2011 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intratümöral | tam yanıt 98% (54 lezyon) | Intralesional agents have a role in the management of cutaneous malignancies. In this article, the efficacy, side effects, strengths, limitations, costs, and practical considerations regardi… |
| ECT | Testori et al · Treatment of Metastatic Melanoma | 2011 | Derleme | Literatür Analizi | Sistemik / Abskopal İmmün Yanıt | 52 | – | bleomisin · intravenöz | tam yanıt 66% (98 lezyon) | About 68,130 new melanomas will be diagnosed in the United States during 2010 (38,870 men: 29,260 women) and of those 8,700 people will die of the disease (5,670 men; 3,030 women). The death… |
| Diğer EP | C. Heller et al · Curr Gene Ther | 2010 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | – | – | – | – | In vivo electroporation (EP) is a versatile delivery method for gene transfer which can be applied to any accessible tissue. Delivery of plasmid DNA encoding therapeutic genes or cDNAs with … |
| ECT | Möller et al · Expert Rev Anticancer Ther | 2009 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 52 / 40 | – | bleomisin · intravenöz | – | Treatment of recurrent or in-transit unresectable melanoma continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a therapeutic option for those patients whose lesions a… |
| ECT | Byrne et al · Expert Rev Anticancer Ther | 2006 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin · intratümöral | nesnel yanıt 85.3% (273 lezyon) | Electroporation is a novel therapeutic modality that uses pulsed electrical currents to enhance the uptake of drugs, vaccines and genes into cells, and has been used for over 20 years. Elect… |
| ECT | Sersa · European Journal of Cancer Supplements | 2006 | Derleme | Literatür Analizi | – | – / 1009 | – | bleomisin · intravenöz | nesnel yanıt 80% | The first clinical study on electrochemotherapy was published in 1991, reporting good treatment effectiveness of electrochemotherapy on cutaneous tumour nodules of head and neck tumours.1 Th… |
| ECT | Molina-Pineda et al · Pharmaceutics | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | ELECTROvet EZ | diğer · intratümöral | tam yanıt 1 adet (1 hayvan) | Background/Objectives: Melanoma affects both sexes, and its incidence has increased in recent years. It is currently among the most common types of cancer. Standard chemotherapy, although ef… |
| ECT | Molina-Pineda et al · – | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | ELECTROvet EZ | – | – | Background/Objectives: Melanoma affects both sexes, and its incidence has increased in recent years. It is currently among the most common types of cancer. Standard chemotherapy, although ef… |
| Gen ET | Brišar · Sci Rep | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | ELECTROcell B10 HVLV | plazmid DNA · intratümöral | – | Our study introduces a novel bacteriophage-based vaccine strategy and evaluates its antitumor efficacy, both as a standalone therapy and in combination with gene electrotransfer (GET) of int… |
| Diğer EP | Heller et al · Mol Ther Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | custom-built electrotransfer system | plazmid DNA · intratümöral | genel sağkalım 80.89% (10 hayvan) | Interleukin-12 (IL-12) is a potent immune stimulator that induces the proliferation and activation of natural killer (NK) and T cells and the secretion of interferon (IFN)-γ. While IL-12 is … |
| Diğer EP | Kamenšek · Pharmaceutics | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator, GT-01 pulse generator | plazmid DNA | – | Background/Objectives : Mesenchymal stromal cells (MSCs) hold the potential for tumor-targeted gene delivery due to their ex vivo manipulability, low immunogenicity, scalability, and inheren… |
| ECT | Omerzel et al · Radiol Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | GeneDrive, Cliniporator | plazmid DNA · intratümöral | transfeksiyon verimi 35% | Background: In recent years, various gene therapy strategies have been developed for cancer treatment. One of these strategies is electroporation-based delivery of therapeutic transgenes - g… |
| ECT | Uršič Valentinuzzi et al · Front Immunol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Sistemik / Abskopal İmmün Yanıt, Bleomisin Hücre İçi Birikiminin Artması | – | BetaTech, ELECTRO Cell B10 | bleomisin · intratümöral | – | Introduction: In addition to its direct cytotoxic effects, ablative therapies as electrochemotherapy (ECT) can elicit indirect antitumor effects by triggering immune system responses. Here, … |
| IRE | Wu et al · Cancer Immunol Immunother | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | custom-made IRE device | – | tam yanıt 62.5% (8 hayvan) | Background: Melanoma is one of the deadliest forms of skin cancer. Irreversible electroporation (IRE) is an innovative, non-thermal ablation technology for treating irresectable solid cancer… |
| Kalsiyum EP | Anastasova et al · Pharmaceuticals (Basel) | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – | Cliniporator | diğer · intratümöral | – | Uveal melanoma (UM) represents a rare tumor of the uveal tract and is associated with a poor prognosis due to the high risk of metastasis. Despite advances in the treatment of UM, the mortal… |
| Gen ET | Heller · Mol Ther Nucleic Acids | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, İnterlökin-12 Aracılı İmmün Uyarım | – | BTX ECM830 | plazmid DNA · intratümöral | – | Interleukin-12 (IL-12) gene electrotransfer (GET) delivery is highly effective in inducing long-term, complete regression in mouse and human melanoma and other solid tumors. Therapeutic effi… |
| ECT | Mickevičiūtė et al · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | – | kalsiyum klorür · intratümöral | genel sağkalım 14 gün (6 hayvan) | The phenomenon known as bipolar cancellation is observed when biphasic nanosecond electric field pulses are used, which results in reduced electroporation efficiency when compared to unipola… |
| Kalsiyum EP | Tsimpaki et al · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – / 109 | Cliniporator | bleomisin · intratümöral | – | Despite recent advancements in the diagnosis and treatment of uveal melanoma (UM), its metastatic rate remains high and is accompanied by a highly dismal prognosis, constituting an unmet nee… |
| Gen ET | Ušaj · J Membr Biol | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Cell-based therapies hold great potential for cancer immunotherapy. This approach is based on manipulation of dendritic cells to activate immune system against specific cancer antigens. For … |
| Kalsiyum EP | Lisec et al · Front Immunol | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Bleomisin Hücre İçi Birikiminin Artması | – | GT-01, ELECTRO cell B10 HVLV, Cliniporator | kalsiyum klorür · intratümöral | tam yanıt 18% | Introduction: In calcium electroporation (CaEP), electroporation enables the cellular uptake of supraphysiological concentrations of Ca 2+ , causing the induction of cell death. The effectiv… |
| Gen ET | Savarin · Int J Mol Sci | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | – | ELECTRO CELL B10 | plazmid DNA · intratümöral | tam yanıt 50% (8 hayvan) | Targeting the tumor vasculature through specific endothelial cell markers involved in different signaling pathways represents a promising tool for tumor radiosensitization. Two prominent tar… |
| Gen ET | Tellado et al · Vaccines (Basel) | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | EPV-200 | bleomisin · intravenöz | nesnel yanıt 80% (10 hasta) | Electrochemotherapy (ECT) is a standard of care in veterinary and human oncology. The treatment induces a well-characterized local immune response which is not able to induce a systemic resp… |
| Gen ET | Kamensek · Heliyon | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator | – | – | Interleukin 12 (IL-12) is a cytokine used as a therapeutic molecule in cancer immunotherapy. Gene electrotransfer mediated delivery of IL-12 gene has reached clinical evaluation in the USA u… |
| ECT | Vizintin et al · Radiol Oncol | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | – | laboratory prototype pulse generator | – · diğer yol | – | Background: Nanosecond electric pulses showed promising results in electrochemotherapy, but the underlying mechanisms of action are still unexplored. The aim of this work was to correlate ce… |
| ECT | Brloznik et al · Sci Rep | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | – | ELECTRO CELL B10, Cliniporator | – · intratümöral | – | Electrochemotherapy with bleomycin (ECT BLM) is an effective antitumor treatment already used in clinical oncology. However, ECT alone is still considered a local antitumor therapy because i… |
| Gen ET | Savarin · Int J Mol Sci | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | – | – | – | – | Targeting tumor vasculature through specific endothelial cell markers represents a promising approach for cancer treatment. Here our aim was to construct an antibiotic resistance gene-free p… |
| ECT | Chung et al · Cancers (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | Cliniporator | bleomisin | – | The effectiveness of electrochemotherapy (ECT) in local eradication of tumours in human and veterinary medicine has been proven. ECT consists of increasing the uptake of cytotoxic drugs by m… |
| Gen ET | Kranjc · Vaccines (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | Cliniporator | diğer · intratümöral | – | The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference… |
| Gen ET | Kranjc · Vaccines (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | GT-01, ELECTRO CELL B10 | plazmid DNA · intratümöral | tam yanıt 81% (16 hayvan) | In this study, radiotherapy was combined with the gene electrotransfer (GET) of plasmid encoding shRNA against melanoma cell adhesion molecule (pMCAM) with dual action, which was a vascular-… |
| Gen ET | Remic · Vaccines (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | – | – | plazmid DNA | – | Tumor cell-based vaccines use tumor cells as a source of tumor-associated antigens. In our study, we aimed to develop and test a tumor vaccine composed of tumor cells killed by irradiation c… |
| Gen ET | Shirley · Cancers (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | BTX ECM830 | plazmid DNA · intratümöral | – | Gene electrotransfer (GET) is a safe, reliable, and effective method of delivering plasmid DNA (pDNA) to solid tumors. GET has been previously used to deliver interleukin-15 (IL-15) to mouse… |
| Kalsiyum EP | Tremble · Sci Rep | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | – | BTX ECM 2001 | kalsiyum klorür · diğer yol | – | Electroporation in combination with chemotherapy is an established treatment used on solid malignancies that results in enhanced chemotherapeutic uptake. Recent advances have begun to transi… |
| Diğer EP | Pasquet et al · J Immunother Cancer | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Reversible Membran Permeabilizasyonu | – | – | plazmid DNA | – | Background: Melanoma is a very aggressive skin tumor that can be cured when diagnosed and treated in its early stages. However, at the time of identification, the tumor is frequently in a me… |
| ECT | Fiorentzis et al · Cancers (Basel) | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Cliniporator | bleomisin · intratümöral | – | Uveal melanoma (UM) is the most common primary intraocular tumor that arises from neoplastic melanocytes in the choroid, iris, and ciliary body. Electrochemotherapy (ECT) has been successful… |
| Gen ET | Bosnjak · Cancers (Basel) | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | GT-01, ELECTRO cell B10 | plazmid DNA · intratümöral | tam yanıt 1 oran (12 hayvan) | Several studies have shown that different control plasmids may cause antitumor action in different murine tumor models after gene electrotransfer (GET). Due to the differences in GET protoco… |
| ECT | Groselj et al · Basic Clin Pharmacol Toxicol | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – / 6 | GT-01, Cliniporator | diğer · intravenöz | tümör hacmi değişimi 20.3 gün (6 hayvan) | Pre-clinical and clinical data indicate differences in the responses of melanoma and carcinoma tumours to electrochemotherapy. The purpose of this study was to investigate the origin of this… |
| Diğer EP | Kamensek · Cancer Immunol Immunother | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | Electro Cell B10 | plazmid DNA · intratümöral | tam yanıt 28.6% | Gene electrotransfer (GET) is one of the most efficient non-viral gene therapy approaches for the localized transfer of multiple genes into tumors in vivo; therefore, it is especially promis… |
| Gen ET | Kamensek et al · Cancers (Basel) | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | Electro Cell B10 | – | – | Plasmids, which are currently used in interleukin 12 (IL-12) gene electrotransfer (GET) clinical trials in the USA, contain antibiotic resistance genes and are thus, according to the safety … |
| Gen ET | Shi · Cancers (Basel) | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | – | – | plazmid DNA · intratümöral | – | Metastatic melanoma is an aggressive skin cancer with a relatively low survival rate. Immune-based therapies have shown promise in the treatment of melanoma, but overall complete response ra… |
| ECT | Ursic et al · Bioelectrochemistry | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, İmmünojenik Hücre Ölümü (ICD) | – | GT-01, ELECTRO Cell B10 | diğer · intratümöral | tümör hacmi değişimi 23 gün (6 hayvan) | Interest in platinum-based chemotherapeutics such as oxaliplatin (OXA) and cisplatin (CDDP) has been reinvigorated by their newly described impacts on tumor-specific immune responses. In add… |
| Gen ET | Lampreht · Mediators Inflamm | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | ELECTRO cell B10 HVLV | plazmid DNA · intratümöral | – | Cancer immunotherapy is currently one of the leading approaches in cancer treatment. Gene electrotransfer of plasmids encoding interleukin 12 (IL-12) into the cells leads to the production o… |
| Gen ET | Savarin · Radiol Oncol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | – / 1 | ELECTRO CELL B10 | plazmid DNA · intratümöral | – | Background: Tumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of therapeutic genes is on… |
| ECT | Kranjc et al · Radiol Oncol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Darbe Parametrelerinin Optimizasyonu | – / 32 | TESLA Stym | sisplatin · intravenöz | tümör hacmi değişimi 2.3 gün | Introduction: Pulsed electromagnetic field (PEMF) induces pulsed electric field, which presumably increases membrane permeabilization of the exposed cells, similar to the conventional electr… |
| Gen ET | Bosnjak et al · Gene Ther | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | ELECTRO CELL B10, Cliniporator, GT-01 | plazmid DNA · intratümöral | tam yanıt 17% (18 hayvan) | Gene therapy with Plasmid AMEP (antiangiogenic metargidin peptide) has recently been studied as a potential targeted therapy for melanoma. This plasmid is designed to downregulate α5β1 and α… |
| Gen ET | Dolinsek et al · Cancers (Basel) | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | ELECTRO CELL B10 | plazmid DNA · intratümöral | tam yanıt 23% (12 hayvan) | Endoglin overexpression is associated with highly proliferative tumor endothelium and also with some tumors, including melanoma. Its targeting has anti-tumor effectiveness, which can also be… |
| Gen ET | Forde · Gene Ther | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | ePORE | plazmid DNA · intratümöral | – | Antitumour efficacy of electroporated pEEV, coding for granulocyte-macrophage colony-stimulating factor and the B7-1 costimulatory immune molecule (pEEVGmCSF-b7.1) in growing solid tumours, … |
| Gen ET | Forde · Cancer Gene Ther | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | ePORE | plazmid DNA · intratümöral | – | Regulatory T cells (T-regs) can negatively impact tumor antigen-specific immune responses after infiltration into tumor tissue. However, depletion of T-regs can facilitate enhanced anti-tumo… |
| Gen ET | Shirley et al · Curr Gene Ther | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | BTX ECM830 | plazmid DNA | – | Effective delivery still remains a major hurdle in the development of gene based therapies. While technological advances have occurred that have improved delivery in general, there is still … |
| ECT | Daeschlein et al · Exp Dermatol | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator | bleomisin · intravenöz | – | The study was undertaken to compare antitumor efficacy of electrochemotherapy (ECT) with cold plasma therapy (CP) in a melanoma mouse model. After melanoma implantation into the flank of C57… |
| Diğer EP | Sin et al · Cancer Immunol Immunother | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım | – | Cellectra | plazmid DNA · intratümöral | tam yanıt 10 adet (15 hayvan) | Intratumoral electroporation (IT-EP) with IL-12 cDNA (IT-EP/IL12) can lead to the eradication of established B16 melanoma tumors in mice. Here, we explore the immunological mechanism of the … |
| Diğer EP | Spugnini et al · J Transl Med | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Sisplatin Hücre İçi Birikiminin Artması | – / 8 | Chemopulse | diğer · intravenöz | tümör hacmi değişimi 50% (8 hasta) | Background: Nucleic acids designed to modulate the expression of target proteins remain a promising therapeutic strategy in several diseases, including cancer. However, clinical success is l… |
| Diğer EP | Lladser et al · Cancer Immunol Immunother | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Derma Vax™ DNA vaccine Skin Delivery System | – · intratümöral | – | Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large variety of tumors and also in tumor associated endothelial cells but mostly absent in differentiate… |
| Diğer EP | Kang et al · Cancer Lett | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Gene Pulser Xcell, CUY 21 Electroporator | plazmid DNA | lokal kontrol 0% (3 örnek) | Electroporation is a useful means for non-viral gene delivery. Here, we investigated the use of electroporation to deliver polymer-DNA complexes into living cells using a protein kinase C (P… |
| Diğer EP | Spugnini et al · Microsc Res Tech | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Chemopulse | – | – | Electroporation (EP) has been widely employed in the past years as a safe and effective technique to drive drugs and DNA plasmids into target cells both for experimental and therapeutic purp… |
| Diğer EP | McCray et al · Mol Ther | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu | – | BTX T820 pulse generator, autoswitcher, custom-made applicator containing six penetrating electrodes | plazmid DNA · intratümöral | tam yanıt 14.29% (14 hayvan) | Novel therapies and delivery methods directed against malignancies such as melanoma, and particularly metastatic melanoma, are needed. The HIV-1 accessory protein Vpr (viral protein R) has p… |
| Diğer EP | Ayyavoo et al · Molecular Therapy | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu | – | – | plazmid DNA · intratümöral | tam yanıt 20% | Melanoma is an aggressive form of skin cancer. Effective treatment of this disease requires the development of new therapeutic strategies. One promising strategy is treatment of the tumor wi… |
| ECT | Entin et al · Clin Cancer Res | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | – | Grass S48 Stimulator | – · intratümöral | – | Purpose: The exposure of cells in vitro to trains of low voltage-pulsed electric fields in the range of 20-100 V/cm was previously shown to induce an efficient uptake of macromolecules with … |
| ECT | Heller et al · Melanoma Res | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | CytoPulse PA4000, CytoPulse PA4000 DC pulse generator | bleomisin · intratümöral | tam yanıt 12.5% (8 hayvan) | When cancer cells, including melanoma cells, are genetically altered to secrete cytokines, irradiated and injected into subjects, long-term antitumour immunity is induced. Optimally, existin… |
| ECT | Heller et al · Melanoma Res | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electrochemotherapy (ECT), chemotherapy administered in combination with electric fields, has the potential to be an effective localized treatment for cutaneous malignancies. Bleomycin's cyt… |
| Diğer EP | Heller et al · Bioelectrochemistry and Bioenergetics | 1995 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | T820 DC generator | bleomisin · intravenöz | tam yanıt 20 adet (35 hayvan) | Bu yayında özet bulunmuyor. |
| IRE | Blažič et al · Sci Rep | 2025 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | L-POR | – | – | High-intensity pulsed electric fields induce transient increase in membrane permeability, a phenomenon known as electroporation, with broad applications in medicine, including electrochemoth… |
| ECT | Coskun et al · Bioelectricity | 2024 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM830 | diğer | hücre canlılığı 79% | Electrochemotherapy (ECT) involves locally applying electrical pulses to permeabilize cell membranes, using electroporation (EP). This process enhances the uptake of low-permeant chemotherap… |
| ECT | Heinzelmann et al · J Clin Med | 2023 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | – | Cliniporator | bleomisin · diğer yol | – | Background: Conjunctival melanoma (CM) is associated with a high rate of local recurrence and poor survival rate. Novel therapeutic options are needed to reduce recurrence rate. The objectiv… |
| IRE | Lv et al · IEEE Trans Biomed Eng | 2023 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – | Zhengzhou University prototype pulse generator | bleomisin · hem intravenöz hem intratümöral | – | Hundreds of high frequency bipolar pulse bursts with ∼1 μs have been suggested to alleviate muscle contractions and pain during the irreversible electroporation (IRE) tumor treatment. This s… |
| Kalsiyum EP | Kraemer et al · Cancers (Basel) | 2022 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – | Genedrive, Genedrive voltage pulse generator | kalsiyum klorür | – | Electrochemotherapy (ECT) is the combination of transient pore formation following electric pulse application with the administration of cytotoxic drugs, which enhances the cytotoxic effect … |
| Diğer EP | Rao et al · Sci Rep | 2022 | İn Vitro Çalışma | Hücre Kültürü | Nanosaniye Darbeli Elektrik Alan (nsPEF), İrreversible Por Oluşumu ve Hücre Ölümü | – | self-developed digital pulse generator | – | – | Microsecond pulsed electric fields (PEF) have previously been used for various tumour therapies, such as gene therapy, electrochemotherapy and irreversible electroporation (IRE), due to its … |
| ECT | Fiorentzis et al · Cancers (Basel) | 2021 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Genedrive | bleomisin | – | Electrochemotherapy (ECT) is emerging as a complementary treatment modality for local tumor control in various cancer entities. Irradiation is an established therapeutic option for oncologic… |
| Diğer EP | Choromanska et al · Pharmaceutics | 2020 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | BTX ECM830 | diğer | – | Melanoma is one of the most serious skin cancers. The incidence of this malignant skin lesion is continuing to increase worldwide. Melanoma is resistant to chemotherapeutic drugs and highly … |
| ECT | Fiorentzis et al · Biomedicines | 2020 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | – | – | bleomisin | – | Three-dimensional (3D) cell cultures represent small avascular tumors in vitro and simulate some of the biological characteristics of solid tumors, enhancing the evaluation of anticancer dru… |
| IRE | Szlasa et al · Molecules | 2020 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) is today used as an alternative to surgery for the excision of cancer lesions. This study aimed to investigate the oxidative and cytotoxic effects the cell… |
| ECT | Fiorentzis et al · Acta Ophthalmol | 2019 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin | hücre canlılığı 6.5% (3 örnek) | Purpose: To investigate the cytotoxic effect of bleomycin, mitomycin C (MMC) and Fluorouracil (5-FU) in combination with electroporation (EP) on human conjunctival melanoma (CM) and normal c… |
| ECT | Scuderi et al · Radiol Oncol | 2019 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | – | BetaTech | sisplatin | hücre canlılığı 32.16% (1 bildirilmemiş) | Background In electrochemotherapy (ECT), chemotherapeutics are first administered, followed by short 100 μs monopolar pulses. However, these pulses cause pain and muscle contractions. It is … |
| Diğer EP | Choromanska et al · Bioelectrochemistry | 2018 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | – | Gene Pulser Xcell | diğer | hücre canlılığı 43% | There are still not specified mechanisms how beta-glucan molecules are transported into cells. Supposing, beta-glucan toxicity against tumor cells may be related to the overexpression of the… |
| ECT | Fiorentzis et al · Neoplasma | 2018 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Bleomisin Hücre İçi Birikiminin Artması | – | Cliniporator | bleomisin | hücre canlılığı 74% | Electrochemotherapy (ECT) enhances responsiveness to cytotoxic drugs in numerous cell lines in vitro. Clinically ECT is widely applied for skin tumor ablation and has shown efficacy in treat… |
| ECT | Dolinsek et al · Radiol Oncol | 2016 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | GT-01 | bleomisin | – | Background: The aim of the study was to explore the effectiveness of electrochemotherapy (ECT) during the treatment of melanoma patients with BRAF inhibitors. Its effectiveness was tested on… |
| Diğer EP | Kulbacka et al · Cell Stress Chaperones | 2013 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | BTX ECM830, Petri Pulser applicator | diğer | – | Two porphyrins, CoTPPS and MnTMPyPCl5, were tested for their photodynamic activity and potential novel use in a therapy of human cancers. We investigated an effect of photodynamic reaction (… |
| ECT | Gerlini et al · Clin Exp Metastasis | 2012 | İn Vitro Çalışma | Hücre Kültürü | – | 9 | – | bleomisin · intravenöz | – | Electrochemotherapy (ECT) is a novel treatment for recurrent or in-transit unresectable melanoma metastases based on the administration of anti-neoplastic drugs followed by cancer cell elect… |
| ECT | Todorovic et al · Radiol Oncol | 2012 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması | – | in-house build electroporator | bleomisin | – | Background: Electrochemotherapy is a local treatment combining chemotherapy and electroporation and is highly effective treatment approach for subcutaneous tumours of various histologies. Co… |
| ECT | Todorovic et al · Melanoma Res | 2011 | İn Vitro Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Bleomisin Hücre İçi Birikiminin Artması | – | – | sisplatin | – | Electrochemotherapy is a local treatment combining chemotherapy and application of electric pulses to the tumour. Electrochemotherapy with bleomycin and cisplatin has shown its effectiveness… |
| Gen ET | Mlakar et al · BMC Cancer | 2009 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Apoptoz İndüksiyonu | – | GT-1 electroporator | – | – | Background: Electroporation is a versatile method for in vitro or in vivo delivery of different molecules into cells. However, no study so far has analysed the effects of electric pulses use… |
| IRE | Mandel et al · PLoS One | 2013 | Deneysel Biyofizik Çalışması | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Doku İletkenliği ve Empedans Değişimi | – / 5 | BTX ECM830 | – | – | Uveal melanoma (UM) is the most common primary intraocular tumor in adults and is characterized by high rates of metastatic disease. Although brachytherapy is the most common globe-sparing t… |
| Diğer EP | Fania et al · Discov Oncol | 2021 | Anket / Saha Araştırması | İnsan | – | 110 | – | bleomisin · intratümöral | – | Non-melanoma skin cancers include basal and squamous cell carcinoma. These tumors have become an important health issue for their high incidence and for the morbidity, especially if untreate… |
| Diğer EP | Ascierto et al · J Transl Med | 2022 | Kongre Özeti | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 60 | – | – | – | Advances in immune checkpoint and combination therapy have led to improvement in overall survival for patients with advanced melanoma. Improved understanding of the tumor, tumor microenviron… |
| ECT | Choromańska et al · Adv Clin Exp Med | 2023 | Editöryal / Mektup | İnsan | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | The cell membrane can be permeabilized when subjected to calibrated short electric pulses. This membrane alteration can be reversible, leaving cell viability unaffected. This set of events i… |
| ECT | Bastrup et al · Acta Oncol | 2022 | Editöryal / Mektup | İnsan | – | – | – | – | – | Electrochemotherapy (ECT) is a treatment method, which uses electroporation to permeabilize the cell membrane and improve the delivery of chemotherapy into cells, thus increasing the cytotox… |
| ECT | Gerlini et al · Oncoimmunology | 2012 | Editöryal / Mektup | belirsiz | – | – | – | bleomisin | – | Combining electrochemotherapy with dendritic cell-based immunotherapy is a promising strategy against human metastatic melanoma that deserves to be clinically assessed. While electrochemothe… |
| ECT | Quaglino et al · Pigment Cell Melanoma Res | 2011 | Editöryal / Mektup | İnsan | – | 15 | Cliniporator | bleomisin · intravenöz | nesnel yanıt 8 oran (15 hasta) | , Electrochemotherapy (ECT) represents a new therapeutic option for primary and metastatic skin tumours (Mir et al., 2006). In recent years, many studies have shown its clinical efficacy in … |
| ECT | Giraud et al · Int J Radiat Oncol Biol Phys | 1996 | Editöryal / Mektup | İnsan | – | 4 / 58 | PS 15 | bleomisin · intravenöz | tam yanıt 4 adet (58 lezyon) | Infusional brachytherapy, the use of macroaggregated albumin and colloidal 32P in solid tumors, has been easy to reproduce in the clinic in Uppsala, Sweden; Brussels, Belgium; Seoul, Korea; … |
| ECT | Campana et al · Eur J Surg Oncol | 2025 | Düzeltme / Erratum | – | – | – | – | – | – | European Journal of Surgical Oncology 51 (2025) 111158 Contents lists available at ScienceDirect European Journal of Surgical Oncology journal homepage: www.ejso.com Corrigendum to “Treatmen… |
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