Malign Melanom
Deri ve Yüzeyel Tümörler
Melanomun deri ve deri altı metastazları, elektrokemoterapinin en yoğun çalışıldığı tekil tümör tipidir. Cerrahiye uygun olmayan, çok sayıda ve tekrarlayan lezyonlarda lokal kontrol amacıyla kullanılır. Güncel araştırma hattı, yöntemi immün kontrol noktası inhibitörleriyle birleştirerek lokal tedaviden sistemik yanıt elde etmeye odaklanmaktadır.
175toplam yayın
57klinik çalışma
68preklinik çalışma
23derleme
1996–2026yayın aralığı
Rejime Göre Kanıt Durumu
Reversible elektroporasyon (RE-ECT)
168yayın
56klinik
63preklinik
Klinik Kanıt
1996–2026 · Rutin Klinik Kullanımda
İrreversible elektroporasyon (IRE-ECT)
7yayın
1klinik
5preklinik
Preklinik Kanıt
2013–2026 · Klinik Araştırma Aşamasında
Bu Alanda Raporlanan Mekanizmalar
Terimler, yayın özetleri üzerinde otomatik eşleştirmeyle saptanmıştır; rakam terimin geçtiği yayın sayısını gösterir.
Bleomisin Hücre İçi Birikiminin Artması 54
Gen Elektrotransferi (Plazmid DNA) 34
İnterlökin-12 Aracılı İmmün Uyarım 24
Reversible Membran Permeabilizasyonu 22
İmmün Kontrol Noktası İnhibitörü Kombinasyonu 20
Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu 18
Nekroz ve Nekroptoz 17
Sisplatin Hücre İçi Birikiminin Artması 16
Apoptoz İndüksiyonu 15
Darbe Parametrelerinin Optimizasyonu 15
Sistemik / Abskopal İmmün Yanıt 14
İrreversible Por Oluşumu ve Hücre Ölümü 11
Çalışma Tipi Dağılımı
Çubuk uzunluğu en kalabalık çalışma tipine göre ölçeklenmiştir; yüzde ise alanın tamamındaki payı verir. Renk, çalışma tipinin kanıt basamağını gösterir; kanıt haritasındaki ile aynı ölçek.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Randomize Klinik Çalışma | 3 | %2 |
| Prospektif Klinik Çalışma | 2 | %1 |
| Klinik Çalışma | 44 | %25 |
| Retrospektif Klinik Çalışma | 7 | %4 |
| Vaka Serisi | 1 | <%1 |
| Vaka Raporu | 19 | %11 |
| Sistematik Derleme / Meta-Analiz | 5 | %3 |
| Kılavuz / Uzlaşı | 1 | <%1 |
| Derleme | 18 | %10 |
| Hayvan Çalışması | 59 | %34 |
| İn Vitro Çalışma | 9 | %5 |
| Anket / Saha Araştırması | 1 | <%1 |
| Ön Baskı | 1 | <%1 |
| Editöryal / Mektup | 3 | %2 |
| Düzeltme / Erratum | 1 | <%1 |
| Belirtilmemiş | 1 | <%1 |
Literatür Kanıt Tablosu
175 yayın, kanıt gücü sırasına göre listelenmiştir. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Özet |
|---|---|---|---|---|---|---|
| Reversible | Gaudy et al · J Cutan Med Surg | 2006 | Randomize Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: Electrochemotherapy (ECT) combines intralesional injections of bleomycin with electroporation (EP), which permeabilizes tumor cells and thus increases the bleomycin efficacy at t… |
| Reversible | Byrne et al · Melanoma Res | 2005 | Randomize Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Electroporation therapy (EPT) is a novel treatment modality that uses brief, high-intensity, pulsed electrical currents to enhance the uptake of chemotherapeutic agents, vaccines and genes i… |
| Reversible | Sersa et al · Clin Cancer Res | 2000 | Randomize Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy consists of chemotherapy followed by local application of electric pulses to the tumor to increase drug delivery into the cells. The aim of this Phase II clinical study w… |
| Reversible | Rózsa et al · Dermatologic Therapy | 2025 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Introduction: Immunosuppressed patients face a significantly higher risk of developing malignant skin tumors compared to the general population, often presenting with numerous, rapidly growi… |
| Reversible | Theurich et al · Cancer Immunol Res | 2016 | Prospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sistemik / Abskopal İmmün Yanıt | Immune checkpoint inhibition with ipilimumab has revolutionized cancer immunotherapy and significantly improved outcomes of patients with advanced malignant melanoma. Local peripheral treatm… |
| Reversible | Kempa-Kamińska et al · EJC Skin Cancer | 2026 | Klinik Çalışma | İnsan | – | Differentiating dysplastic nevi from early melanoma remains one of the most challenging issues in daily practice. While dermoscopy and reflectance confocal microscopy have improved diagnosti… |
| Reversible | Caballero-Borrego et al · Braz J Otorhinolaryngol | 2024 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Objectives: To evaluate the efficacy and tolerance after the electrochemotherapy treatment for local therapy of cutaneous and subcutaneous metastases of head-and-neck tumors and malignant me… |
| Reversible | Vissing · Acta Oncol | 2024 | Klinik Çalışma | İnsan | Nekroz ve Nekroptoz, Sistemik / Abskopal İmmün Yanıt | Background and purpose: Calcium electroporation (CaEP) involves injecting calcium into tumour tissues and using electrical pulses to create membrane pores that induce cell death. This study … |
| Reversible | Ascierto et al · J Transl Med | 2022 | Klinik Çalışma | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Advances in immune checkpoint and combination therapy have led to improvement in overall survival for patients with advanced melanoma. Improved understanding of the tumor, tumor microenviron… |
| Reversible | Kraemer et al · Cancers (Basel) | 2022 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | Electrochemotherapy (ECT) is the combination of transient pore formation following electric pulse application with the administration of cytotoxic drugs, which enhances the cytotoxic effect … |
| Reversible | Ziętek et al · Postepy Dermatol Alergol | 2022 | Klinik Çalışma | İnsan | – | Introduction: Patients with cutaneous malignant melanoma (MM), in case of non-resectability of the lesions, have only a limited pool of the available treatment options. In recent years espec… |
| Reversible | Fiorentzis et al · Cancers (Basel) | 2021 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy (ECT) is emerging as a complementary treatment modality for local tumor control in various cancer entities. Irradiation is an established therapeutic option for oncologic… |
| Reversible | Sersa et al · European Journal of Surgical Oncology | 2021 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | While the risks associated with sentinel lymph node (SLN) biopsy in the regional nodal staging for malignant melanoma are low, efforts have been made at identifying patients in whom the proc… |
| Reversible | Ascierto et al · J Transl Med | 2020 | Klinik Çalışma | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | The melanoma treatment landscape changed in 2011 with the approval of the first anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 checkpoint inhibitor and of the first BRAF-targeted mo… |
| Reversible | Jamsek et al · Radiol Oncol | 2020 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | Background Electrochemotherapy (ECT) is a local cancer treatment based on electroporation where the electric field is used to enhance cell membrane permeability and thereby facilitating the … |
| Reversible | Campana et al · European Journal of Surgical Oncology | 2019 | Klinik Çalışma | İnsan | – | Electrochemotherapy (ECT) has evolved considerably over the past decade, but its application is yet to be standardized. In fact, a lack of agreement exists on eligible patients, timing of tr… |
| Reversible | Odili et al · European Journal of Surgical Oncology | 2019 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Basal cell carcinoma(BCC) is one of the most common skin malignancies worldwide. In comparison to current management strategies for BCC, electrochemotherapy (ECT) proved to be a valid altern… |
| Reversible | Ascierto · J Transl Med | 2018 | Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Metastatic melanoma represents a challenging clinical situation and, until relatively recently, there was an absence of effective treatment options. However, in 2011, the advanced melanoma t… |
| Reversible | Campana et al · Technol Cancer Res Treat | 2018 | Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | Electrochemotherapy is an established treatment option for patients with superficially metastatic tumors, mainly malignant melanoma and breast cancer. Based on preliminary experiences, elect… |
| Reversible | Ascierto · J Transl Med | 2017 | Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Major advances have been made in the treatment of cancer with targeted therapy and immunotherapy; several FDA-approved agents with associated improvement of 1-year survival rates became avai… |
| Reversible | Kunte et al · Br J Dermatol | 2017 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: (ECT) is an effective local treatment for cutaneous metastasis. Treatment involves the administration of chemotherapeutic drugs followed by delivery of electrical pulses to the t… |
| Reversible | Bigi et al · Clin Cosmet Investig Dermatol | 2016 | Klinik Çalışma | İnsan | Apoptoz İndüksiyonu, Nekroz ve Nekroptoz | Background: Electrochemotherapy (ECT) is increasingly used in the treatment of primary and secondary skin tumors, but little is known about the pathologic mechanism responsible for tumor cel… |
| Reversible | Di Gennaro et al · Clin Exp Metastasis | 2016 | Klinik Çalışma | İnsan | İmmünojenik Hücre Ölümü (ICD) | Electrochemotherapy (ECT) represents an effective local treatment for skin unresectable melanoma metastases with high overall objective response rate. ECT is based on the combination of anti… |
| Reversible | Dolinsek et al · Radiol Oncol | 2016 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background: The aim of the study was to explore the effectiveness of electrochemotherapy (ECT) during the treatment of melanoma patients with BRAF inhibitors. Its effectiveness was tested on… |
| Reversible | Grau et al · Braz J Otorhinolaryngol | 2016 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | Introduction: Local progression of papillary thyroid carcinoma (PTC) after failure of standard therapies may cause pain, ulceration, and bleeding. As patients are fully aware of the tumor gr… |
| Reversible | Bhatia et al · European Journal of Cancer | 2015 | Klinik Çalışma | İnsan | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Interleukin-12 (IL-12), a master regulator of adaptive type-1 immunity, has demonstrated antitumor efficacy, but is associated with severe toxicities when administered systemically. Local IL-… |
| Reversible | Caracò et al · Melanoma Manag | 2015 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Aim: This study was undertaken to update the outcome of the treated lesions with electrochemotherapy (ECT) plus intravenous injection of bleomycin in patients with in-transit disease or dist… |
| Reversible | Mir-Bonafé et al · Actas Dermo-Sifiliográficas (English Edition) | 2015 | Klinik Çalışma | İnsan | Nekroz ve Nekroptoz | Electrochemotherapy is indicated for the treatment of unresectable cutaneous and subcutaneous tumors. The technique involves the synergistic use of electroporation of cell membranes to incre… |
| Reversible | Mozzillo et al · J Transl Med | 2014 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background Treatment of early and multiple cutaneous unresectable recurrences is a major therapeutic problem with around 80% of patients relapsing within 5 years [1]. For lesions refractory … |
| Reversible | Caracò et al · BMC Cancer | 2013 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: Treatment of early and multiple cutaneous unresectable recurrences is a major therapeutic problem with around 80% of patients relapsing within 5 years. For lesions refractory to … |
| Reversible | Rastrelli et al · ISRN Dermatol | 2013 | Klinik Çalışma | İnsan | – | This paper reviews the epidemiology, diagnosis, and treatment of M zero cutaneous melanoma including the most recent developments. This review also examined the main risk factors for melanom… |
| Reversible | Ricotti et al · Dermatol Ther | 2013 | Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi | Treatment of multiple cutaneous and subcutaneous melanoma metastases is still represents a therapeutic challenge for both dermatologists and oncologists. Electrochemotherapy (ECT) is a promi… |
| İrreversible | Mandel et al · PLoS One | 2013 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Doku İletkenliği ve Empedans Değişimi | Uveal melanoma (UM) is the most common primary intraocular tumor in adults and is characterized by high rates of metastatic disease. Although brachytherapy is the most common globe-sparing t… |
| Reversible | Campana et al · Br J Surg | 2012 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: The aim of the study was to determine predictive factors for effectiveness, toxicity and local disease control in patients with malignant melanoma treated with bleomycin-based el… |
| Reversible | Di Monta et al · European Journal of Surgical Oncology (EJSO) | 2012 | Klinik Çalışma | İnsan | – | Peritoneal carcinomatosis of whatever origin has been considered a systemic metastatic condition with extremely poor prognosis. Combining cytoreductive surgery with hyperthermic intraperiton… |
| Reversible | Gerlini et al · Clin Exp Metastasis | 2012 | Klinik Çalışma | İnsan | – | Electrochemotherapy (ECT) is a novel treatment for recurrent or in-transit unresectable melanoma metastases based on the administration of anti-neoplastic drugs followed by cancer cell elect… |
| Reversible | Mozzillo et al · European Journal of Surgical Oncology (EJSO) | 2012 | Klinik Çalışma | İnsan | – | The treatment of iliac obturator lymph nodes in groin metastasis from melanoma is still a matter of contention. Iliac obturator laparoscopic lymphadenectomy via the transperitoneal route is … |
| Reversible | Testori et al · Dermatol Ther | 2012 | Klinik Çalışma | İnsan | Sistemik / Abskopal İmmün Yanıt | Nowadays, melanoma is one of the most common fatal malignancy of young adults. Incidence is increasing, but mortality rates from melanoma have remained stable. In-transit metastases from ext… |
| Reversible | Farricha et al · Melanoma Research | 2010 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Introduction We started to perform Electrochemotherapy (ECT) in Lisbon since February 2008. We initially treated mainly Melanoma patients but with the growing knowledge on this technique we … |
| Reversible | Kyrgias et al · Melanoma Research | 2010 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Introduction ECT is based on the local delivery of electric pulses that causes transient permeabilisation of the cell membrane, facilitating the intracellular delivery of chemotherapeutic dr… |
| Reversible | Bonehill et al · Clin Cancer Res | 2009 | Klinik Çalışma | İnsan | – | Purpose: A critical factor determining the effectiveness of currently used dendritic cell (DC)-based vaccines is the DC activation or maturation status. We have recently shown that the T-cel… |
| Reversible | Campana et al · Ann Surg Oncol | 2009 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | Electrochemotherapy (ECT) has emerged as a complementary treatment for superficial metastases. Fifty-two consecutive patients with different cancer histotypes, mainly melanoma and breast can… |
| Reversible | Daud et al · J Clin Oncol | 2008 | Klinik Çalışma | İnsan | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | Purpose: Gene-based immunotherapy for cancer is limited by the lack of safe, efficient, reproducible, and titratable delivery methods. Direct injection of DNA into tissue, although safer tha… |
| Reversible | Quaglino et al · Ann Surg Oncol | 2008 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background: Electrochemotherapy (ECT) combines chemotherapy and electroporation to increase drug uptake. Its role in cutaneous melanoma metastasis treatment is not well defined; indeed, few … |
| Reversible | Sersa · European Journal of Cancer Supplements | 2006 | Klinik Çalışma | İnsan | – | The first clinical study on electrochemotherapy was published in 1991, reporting good treatment effectiveness of electrochemotherapy on cutaneous tumour nodules of head and neck tumours.1 Th… |
| Reversible | Gehl et al · Melanoma Res | 2000 | Klinik Çalışma | İnsan | Hemostaz ve Kanama Kontrolü, Bleomisin Hücre İçi Birikiminin Artması | Electric pulses can cause transient permeabilization of cell membranes (electroporation) and this can be utilized to increase the uptake of chemotherapy (electrochemotherapy). Preclinical st… |
| Reversible | Rols et al · Melanoma Res | 2000 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy is a new anticancer therapy in which transient permeabilization of cells by an electric field induces a significant increase in the bleomycin concentration and toxicity i… |
| Reversible | Serša et al · Melanoma Res | 2000 | Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | The application of electric pulses to skin tumour nodules enhances the antitumour effectiveness of cisplatin. This treatment approach, known as electrochemotherapy, was employed in the treat… |
| Reversible | Glass · Arch Dermatol | 1996 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | Background Electroporation is a new technique that enhances the antitumor effects of chemotherapy by exposing cancerous tissues to pulses of electricity. When used in combination with conven… |
| Reversible | Siegmund et al · Cancers (Basel) | 2025 | Retrospektif Klinik Çalışma | İnsan | – | Background/Objectives : Electrochemotherapy (ECT) has emerged as a promising locoregional treatment modality for patients with cutaneous and subcutaneous melanoma metastases. While systemic … |
| Reversible | Campana et al · European Journal of Surgical Oncology | 2024 | Retrospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sistemik / Abskopal İmmün Yanıt | Adjuvant BRAF/MEK inhibitors and immunotherapy with anti-PD-1 have become the standard of care for resected high-risk stage III and IV melanoma, but a head-to-head comparison in a clinical t… |
| Reversible | Zdzienicki et al · J Clin Med | 2024 | Retrospektif Klinik Çalışma | İnsan | – | Background/Objectives : Despite observing progress in recent years in the treatment of patients with advanced melanoma, the optimal management of locoregional recurrence has not been determi… |
| Reversible | Mohr et al · Adv Ther | 2019 | Retrospektif Klinik Çalışma | İnsan | – | Introduction: Talimogene laherparepvec is a first-in-class oncolytic immunotherapy for intratumoral injection with proven efficacy and tolerability in patients with unresectable early metast… |
| Reversible | Heppt et al · Cancer Immunol Immunother | 2016 | Retrospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Growing evidence suggests that concurrent loco-regional and systemic treatment modalities may lead to synergistic anti-tumor effects in advanced melanoma. In this retrospective multicenter s… |
| Reversible | Hribernik et al · Radiol Oncol | 2016 | Retrospektif Klinik Çalışma | İnsan | – | Background: The combination of electrochemotherapy with immuno-modulatory treatments has already been explored and proven effective. However, the role of interferon alpha (IFN-α) adjuvant th… |
| Reversible | Mozzillo et al · Oncoimmunology | 2015 | Retrospektif Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Bleomisin Hücre İçi Birikiminin Artması | Melanoma is responsible for most skin cancer-related deaths and is one of the most common cancers diagnosed in young adults. In melanoma, tumors can become established by activation of the n… |
| Reversible | YazdanParast et al · Technol Cancer Res Treat | 2025 | Vaka Serisi | İnsan | – | PurposeThis study aimed to investigate the efficacy of electrochemotherapy on the three common types of skin cancer, including basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (… |
| Reversible | Russano et al · J Pers Med | 2024 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu | Background: Basal cell carcinomas (BCCs) are common human malignancies with a rising incidence in recent years. While BCCs have a low mortality rate, they are often associated with significa… |
| Reversible | Morgese et al · Mol Clin Oncol | 2023 | Vaka Raporu | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Immune checkpoint inhibitors have changed the natural history of advanced melanoma. Despite this, a notable proportion of patients immediately relapse or develop resistance during immunother… |
| Reversible | Vissing et al · Acta Oncol | 2023 | Vaka Raporu | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Calcium electroporation (CaEP) has demonstrated promising results for local treatment of cutaneous metastases from breast cancer, melanoma, and head-and-neck cancer in initial clinical trial… |
| Reversible | Corvino et al · J Ultrasound Med | 2022 | Vaka Raporu | İnsan | – | Cutaneous melanoma incidence is increasing worldwide, representing an aggressive tumor when evolving to the metastatic phase. High-resolution ultrasound (US) is playing a growing role in the… |
| Reversible | Landström et al · Melanoma Manag | 2022 | Vaka Raporu | İnsan | – | Despite the progress in immunotherapy and targeted therapy for patients with cutaneous malignant melanoma not all patients with loco-regional recurrences will respond to treatment. Electroch… |
| Reversible | Russano et al · Oncol Lett | 2022 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | The Buschke-Löwenstein tumor (BLT), also known as giant condyloma acuminatum, is a rare sexually transmitted disease often associated with human papillomavirus types 6 and 11. There are no s… |
| Reversible | Quaresmini et al · Front Oncol | 2021 | Vaka Raporu | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Background: Immunotherapy with immune checkpoint inhibitors is one of the main therapies for advanced melanoma. Nevertheless, albeit remarkable, immunotherapy results are still unsatisfactor… |
| Reversible | Gallagher et al · JPRAS Open | 2020 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | Bleomycin electrochemotherapy (ECT) has emerged as a treatment modality for locally advanced metastatic melanoma over the past decade. The phenomenon of reversible electroporation enhances c… |
| Reversible | Saad et al · Eur J Plast Surg | 2020 | Vaka Raporu | İnsan | – | The management of sinister cutaneous lesions including malignant melanoma in the clinically frail patient tends to present clinicians with a professional and ethical dilemma on the optimal b… |
| Reversible | Falk et al · Acta Oncol | 2017 | Vaka Raporu | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Sistemik / Abskopal İmmün Yanıt | In this case study, we report a remarkable systemic response after treatment with electrochemotherapy and calcium electroporation in a patient with disseminated malignant melanoma.Electroche… |
| Reversible | Brizio et al · Eur J Dermatol | 2015 | Vaka Raporu | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Nekroz ve Nekroptoz | Skin metastases represent a relatively frequent event in the natural history of melanoma, developing both in early and in late disease stages. Cutaneous or subcutaneous lesions arise in 15-2… |
| Reversible | Valpione et al · Radiol Oncol | 2015 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: Small molecules that inhibit V600 mutated BRAF protein, such as vemurafenib and dabrafenib, are effective in treatment of metastatic melanoma. Case report: We here describe the c… |
| Reversible | Mozzillo et al · J Transl Med | 2012 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: Approximately 200,000 new cases of melanoma are diagnosed worldwide each year. Skin metastases are a frequent event, occurring in 18.2% of cases. This can be distressing for the … |
| Reversible | Miklavcic et al · Biomed Eng Online | 2010 | Vaka Raporu | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | Background: Electrochemotherapy treats tumors by combining specific chemotherapeutic drugs with an intracellular target and electric pulses, which increases drug uptake into the tumor cells.… |
| Reversible | Snoj et al · Tumori | 2009 | Vaka Raporu | İnsan | Elektrot Geometrisi ve Yerleşimi, Bleomisin Hücre İçi Birikiminin Artması | Aims and background: Electrochemotherapy is an effective local treatment for tumors that combines administration of a chemotherapeutic drug with the subsequent application of electric pulses… |
| Reversible | Snoj et al · Croat Med J | 2007 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | Multiple unresectable melanoma skin metastases pose a treatment problem, especially in centers where isolated limb perfusion is not available. We report the case of a 59-year-old woman who d… |
| Reversible | Gehl et al · European Journal of Cancer Supplements | 2006 | Vaka Raporu | İnsan | Hemostaz ve Kanama Kontrolü | Increasing emphasis is being put on palliation of terminally ill cancer patients. Bleeding skin metastases are one of the many grievances that may negatively affect quality of life. In the s… |
| Reversible | Kubota et al · Melanoma Res | 2005 | Vaka Raporu | İnsan | – | Kubota, Yoko; Tomita, Yoshihiko; Tsukigi, Masaaki; Kurachi, Hirohisa; Motoyama, Teiichi; Mir, Lluis M. Author Information |
| Reversible | Snoj et al · Anticancer Drugs | 2005 | Vaka Raporu | İnsan | Sisplatin Hücre İçi Birikiminin Artması | Anorectal malignant melanoma is a rare tumor and there is no consensus on whether aggressive or local management is more appropriate. Local sphincter-saving excision has been shown to have a… |
| Reversible | Vickars et al · Cureus | 2025 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | Electrochemotherapy (ECT) is a locoregional cancer treatment primarily used in the palliative management of cutaneous metastases from malignant melanoma. However, its clinical effectiveness,… |
| Reversible | Milicevic et al · Int J Mol Sci | 2023 | Sistematik Derleme / Meta-Analiz | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Cutaneous melanoma is a highly aggressive form of skin cancer. The development of immune checkpoint inhibitors (ICIs) has revolutionized the management of advanced melanoma, led to durable r… |
| Reversible | Ferioli et al · Clin Exp Metastasis | 2022 | Sistematik Derleme / Meta-Analiz | İnsan | Nekroz ve Nekroptoz | The main treatment of MM metastases are systemic therapies, surgery, limb perfusion, and intralesional talimogene laherparepvec. Electrochemotherapy (ECT) is potentially useful also due to t… |
| Reversible | Aguado-Romeo et al · Actas Dermosifiliogr | 2017 | Sistematik Derleme / Meta-Analiz | İnsan | – | Electrochemotherapy is a therapeutic option for the treatment of cutaneous and subcutaneous metastases from melanoma and other tumors. The procedure consists of the administration of antican… |
| Reversible | Kis et al · Dermatologic Surgery | 2011 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | OBJECTIVES Electrochemotherapy (ECT) is a novel therapeutic option for the treatment of cutaneous and subcutaneous metastases of malignant melanoma. During the treatment, electric pulses are… |
| Reversible | Campana et al · Br J Surg | 2023 | Kılavuz / Uzlaşı | İnsan | – | Background Skin metastases are an important co-morbidity in melanoma. Despite broad adoption, electrochemotherapy implementation is hindered by a lack of treatment indications, uncertainty r… |
| Reversible | Ahmad et al · J Clin Med | 2024 | Derleme | Literatür Analizi | İnterlökin-12 Aracılı İmmün Uyarım, Sistemik / Abskopal İmmün Yanıt | Electroporation with chemotherapy (ECT) is currently offered as a treatment in Europe for locoregional or metastatic melanoma with cutaneous lesions. However, the role of surgery and other f… |
| Reversible | Criado-Otero et al · Cancers (Basel) | 2024 | Derleme | Literatür Analizi | İnterlökin-12 Aracılı İmmün Uyarım, Sistemik / Abskopal İmmün Yanıt | Cutaneous melanoma is a malignant neoplasm with local and distant metastatic potential. When feasible, surgery is the first line of treatment in locoregionally advanced disease. Topical and … |
| Reversible | Russano et al · Cancers (Basel) | 2024 | Derleme | Literatür Analizi | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | In-transit metastases (ITM) in melanoma present a significant therapeutic challenge due to their advanced stage and complex clinical nature. From traditional management with surgical resecti… |
| Reversible | Justesen et al · Cancers (Basel) | 2022 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The discovery of electroporation in 1968 has led to the development of electrochemotherapy (ECT) and irreversible electroporation (IRE). ECT and IRE have been established as treatments of cu… |
| Reversible | Cucu et al · Materials (Basel) | 2021 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) is an effective bioelectrochemical procedure that uses controlled electrical pulses to facilitate the increase of intracellular concentration of certain substances … |
| Reversible | Sagwal et al · Oxid Med Cell Longev | 2021 | Derleme | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres | Metabolic energy production naturally generates unwanted products such as reactive oxygen species (ROS), causing oxidative damage. Oxidative damage has been linked to several pathologies, in… |
| Reversible | Zawit · Ann Transl Med | 2021 | Derleme | Literatür Analizi | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sisplatin Hücre İçi Birikiminin Artması | Prognosis of metastatic melanoma has undergone substantial improvement with the discovery of checkpoint inhibitors. Immunotherapies and targeted therapies have improved the median overall su… |
| Reversible | Goggins et al · Int J Dermatol | 2018 | Derleme | İnsan | – | Electrochemotherapy (ECT) is a treatment modality that combines low-dose chemotherapy with electroporation, thereby enhancing cytotoxicity. ECT was first utilized in the treatment of metasta… |
| Reversible | Wichtowski et al · Contemp Oncol (Pozn) | 2018 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu | Electrochemotherapy is a new therapeutic option for patients with locally spread melanoma. It is based on the phenomenon of reversible electroporation, i.e. a transient increase in permeabil… |
| Reversible | Campana et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | – | Cutaneous metastases are not unusual in the clinical course of malignant melanoma, occurring in 2–20% of patients, depending on primary tumor features and disease stage. Patients with superfi… |
| Reversible | Rutkowski et al · Melanoma Manag | 2014 | Derleme | Literatür Analizi | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sistemik / Abskopal İmmün Yanıt | The majority of locoregional relapses of cutaneous melanoma occur as subcutaneous local recurrences/in-transit metastases; subcutaneous metastases (SMs) are also common in distant metastases… |
| Reversible | Solivetti et al · J Exp Clin Cancer Res | 2014 | Derleme | İnsan | – | Background: Over the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival … |
| Reversible | Campana et al · J Surg Oncol | 2013 | Derleme | Hayvan (İn Vivo) | – | Superficially metastatic melanoma still represents a challenging situation for oncologists and a distressing condition for patients. In this circumstance, local treatment by electrochemother… |
| Reversible | Wong et al · N Am J Med Sci | 2013 | Derleme | Literatür Analizi | – | Skin metastases are rare in the routine clinical practice of dermatology, but are of major clinical significance because they usually indicate advanced disease. We reviewed the literature on… |
| Reversible | Good et al · J Am Acad Dermatol | 2011 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Intralesional agents have a role in the management of cutaneous malignancies. In this article, the efficacy, side effects, strengths, limitations, costs, and practical considerations regardi… |
| Reversible | C. Heller et al · Curr Gene Ther | 2010 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | In vivo electroporation (EP) is a versatile delivery method for gene transfer which can be applied to any accessible tissue. Delivery of plasmid DNA encoding therapeutic genes or cDNAs with … |
| Reversible | Möller et al · Expert Rev Anticancer Ther | 2009 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Treatment of recurrent or in-transit unresectable melanoma continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a therapeutic option for those patients whose lesions a… |
| Reversible | Byrne et al · Expert Rev Anticancer Ther | 2006 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Electroporation is a novel therapeutic modality that uses pulsed electrical currents to enhance the uptake of drugs, vaccines and genes into cells, and has been used for over 20 years. Elect… |
| Reversible | Blažič et al · Sci Rep | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | High-intensity pulsed electric fields induce transient increase in membrane permeability, a phenomenon known as electroporation, with broad applications in medicine, including electrochemoth… |
| Reversible | Brišar · Sci Rep | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Our study introduces a novel bacteriophage-based vaccine strategy and evaluates its antitumor efficacy, both as a standalone therapy and in combination with gene electrotransfer (GET) of int… |
| Reversible | Heller et al · Mol Ther Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Interleukin-12 (IL-12) is a potent immune stimulator that induces the proliferation and activation of natural killer (NK) and T cells and the secretion of interferon (IFN)-γ. While IL-12 is … |
| Reversible | Kamenšek · Pharmaceutics | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Background/Objectives : Mesenchymal stromal cells (MSCs) hold the potential for tumor-targeted gene delivery due to their ex vivo manipulability, low immunogenicity, scalability, and inheren… |
| Reversible | Omerzel et al · Radiol Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Gen Elektrotransferi (Plazmid DNA) | Background: In recent years, various gene therapy strategies have been developed for cancer treatment. One of these strategies is electroporation-based delivery of therapeutic transgenes - g… |
| Reversible | Uršič Valentinuzzi et al · Front Immunol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Sistemik / Abskopal İmmün Yanıt, Bleomisin Hücre İçi Birikiminin Artması | Introduction: In addition to its direct cytotoxic effects, ablative therapies as electrochemotherapy (ECT) can elicit indirect antitumor effects by triggering immune system responses. Here, … |
| İrreversible | Wu et al · Cancer Immunol Immunother | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Melanoma is one of the deadliest forms of skin cancer. Irreversible electroporation (IRE) is an innovative, non-thermal ablation technology for treating irresectable solid cancer… |
| Reversible | Anastasova et al · Pharmaceuticals (Basel) | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | Uveal melanoma (UM) represents a rare tumor of the uveal tract and is associated with a poor prognosis due to the high risk of metastasis. Despite advances in the treatment of UM, the mortal… |
| Reversible | Heller · Mol Ther Nucleic Acids | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, İnterlökin-12 Aracılı İmmün Uyarım | Interleukin-12 (IL-12) gene electrotransfer (GET) delivery is highly effective in inducing long-term, complete regression in mouse and human melanoma and other solid tumors. Therapeutic effi… |
| Reversible | Mickevičiūtė et al · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | The phenomenon known as bipolar cancellation is observed when biphasic nanosecond electric field pulses are used, which results in reduced electroporation efficiency when compared to unipola… |
| Reversible | Tsimpaki et al · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | Despite recent advancements in the diagnosis and treatment of uveal melanoma (UM), its metastatic rate remains high and is accompanied by a highly dismal prognosis, constituting an unmet nee… |
| Reversible | Ušaj · J Membr Biol | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | Cell-based therapies hold great potential for cancer immunotherapy. This approach is based on manipulation of dendritic cells to activate immune system against specific cancer antigens. For … |
| İrreversible | Fesmire · Front Vet Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Introduction: Integrated time nanosecond pulse irreversible electroporation (INSPIRE) is a novel tumor ablation modality that employs high voltage, alternating polarity waveforms to induce c… |
| Reversible | Lisec et al · Front Immunol | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Bleomisin Hücre İçi Birikiminin Artması | Introduction: In calcium electroporation (CaEP), electroporation enables the cellular uptake of supraphysiological concentrations of Ca 2+ , causing the induction of cell death. The effectiv… |
| Reversible | Lv et al · IEEE Trans Biomed Eng | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | Hundreds of high frequency bipolar pulse bursts with ∼1 μs have been suggested to alleviate muscle contractions and pain during the irreversible electroporation (IRE) tumor treatment. This s… |
| Reversible | Savarin · Int J Mol Sci | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | Targeting the tumor vasculature through specific endothelial cell markers involved in different signaling pathways represents a promising tool for tumor radiosensitization. Two prominent tar… |
| Reversible | Tellado et al · Vaccines (Basel) | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Electrochemotherapy (ECT) is a standard of care in veterinary and human oncology. The treatment induces a well-characterized local immune response which is not able to induce a systemic resp… |
| Reversible | Kamensek · Heliyon | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Interleukin 12 (IL-12) is a cytokine used as a therapeutic molecule in cancer immunotherapy. Gene electrotransfer mediated delivery of IL-12 gene has reached clinical evaluation in the USA u… |
| Reversible | Vega Díez et al · Actas Dermo-Sifiliográficas | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | – | ACTAS Dermo-Sifiliográficas 113 (2022) T817---T818 RESIDENT’S FORUM [Translated article] RF----Electrochemotherapy in the Treatment of Primary and Secondary Skin Tumors FR----Electroquimiotera… |
| Reversible | Vizintin et al · Radiol Oncol | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | Background: Nanosecond electric pulses showed promising results in electrochemotherapy, but the underlying mechanisms of action are still unexplored. The aim of this work was to correlate ce… |
| İrreversible | Rao et al · Sci Rep | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), İrreversible Por Oluşumu ve Hücre Ölümü | Microsecond pulsed electric fields (PEF) have previously been used for various tumour therapies, such as gene therapy, electrochemotherapy and irreversible electroporation (IRE), due to its … |
| Reversible | Brloznik et al · Sci Rep | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | Electrochemotherapy with bleomycin (ECT BLM) is an effective antitumor treatment already used in clinical oncology. However, ECT alone is still considered a local antitumor therapy because i… |
| Reversible | Savarin · Int J Mol Sci | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | Targeting tumor vasculature through specific endothelial cell markers represents a promising approach for cancer treatment. Here our aim was to construct an antibiotic resistance gene-free p… |
| Reversible | Chung et al · Cancers (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | The effectiveness of electrochemotherapy (ECT) in local eradication of tumours in human and veterinary medicine has been proven. ECT consists of increasing the uptake of cytotoxic drugs by m… |
| Reversible | Kranjc · Vaccines (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference… |
| Reversible | Kranjc · Vaccines (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | In this study, radiotherapy was combined with the gene electrotransfer (GET) of plasmid encoding shRNA against melanoma cell adhesion molecule (pMCAM) with dual action, which was a vascular-… |
| Reversible | Remic · Vaccines (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | Tumor cell-based vaccines use tumor cells as a source of tumor-associated antigens. In our study, we aimed to develop and test a tumor vaccine composed of tumor cells killed by irradiation c… |
| Reversible | Shirley · Cancers (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Gene electrotransfer (GET) is a safe, reliable, and effective method of delivering plasmid DNA (pDNA) to solid tumors. GET has been previously used to deliver interleukin-15 (IL-15) to mouse… |
| Reversible | Tremble · Sci Rep | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | Electroporation in combination with chemotherapy is an established treatment used on solid malignancies that results in enhanced chemotherapeutic uptake. Recent advances have begun to transi… |
| Reversible | Fiorentzis et al · Cancers (Basel) | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Uveal melanoma (UM) is the most common primary intraocular tumor that arises from neoplastic melanocytes in the choroid, iris, and ciliary body. Electrochemotherapy (ECT) has been successful… |
| Reversible | Guida et al · Cancers (Basel) | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Background : A limited degree of progression after a response to treatment is labelled as oligoprogression and is a hot topic of metastatic melanoma (MM) management. Rogue progressive metast… |
| Reversible | Rossi et al · Sci Rep | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Apoptoz İndüksiyonu | Accumulating data indicates that some cancer treatments can restore anticancer immunosurveillance through the induction of tumor immunogenic cell death (ICD). Nanosecond pulsed electric fiel… |
| Reversible | Scuderi et al · Radiol Oncol | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | Background In electrochemotherapy (ECT), chemotherapeutics are first administered, followed by short 100 μs monopolar pulses. However, these pulses cause pain and muscle contractions. It is … |
| Reversible | Bosnjak · Cancers (Basel) | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Several studies have shown that different control plasmids may cause antitumor action in different murine tumor models after gene electrotransfer (GET). Due to the differences in GET protoco… |
| Reversible | Groselj et al · Basic Clin Pharmacol Toxicol | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Pre-clinical and clinical data indicate differences in the responses of melanoma and carcinoma tumours to electrochemotherapy. The purpose of this study was to investigate the origin of this… |
| Reversible | Kamensek · Cancer Immunol Immunother | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Gene electrotransfer (GET) is one of the most efficient non-viral gene therapy approaches for the localized transfer of multiple genes into tumors in vivo; therefore, it is especially promis… |
| Reversible | Kamensek et al · Cancers (Basel) | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Plasmids, which are currently used in interleukin 12 (IL-12) gene electrotransfer (GET) clinical trials in the USA, contain antibiotic resistance genes and are thus, according to the safety … |
| Reversible | Shi · Cancers (Basel) | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | Metastatic melanoma is an aggressive skin cancer with a relatively low survival rate. Immune-based therapies have shown promise in the treatment of melanoma, but overall complete response ra… |
| Reversible | Ursic et al · Bioelectrochemistry | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, İmmünojenik Hücre Ölümü (ICD) | Interest in platinum-based chemotherapeutics such as oxaliplatin (OXA) and cisplatin (CDDP) has been reinvigorated by their newly described impacts on tumor-specific immune responses. In add… |
| Reversible | Lampreht · Mediators Inflamm | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Cancer immunotherapy is currently one of the leading approaches in cancer treatment. Gene electrotransfer of plasmids encoding interleukin 12 (IL-12) into the cells leads to the production o… |
| Reversible | Savarin · Radiol Oncol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | Background: Tumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of therapeutic genes is on… |
| Reversible | Kranjc et al · Radiol Oncol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Darbe Parametrelerinin Optimizasyonu | Introduction: Pulsed electromagnetic field (PEMF) induces pulsed electric field, which presumably increases membrane permeabilization of the exposed cells, similar to the conventional electr… |
| Reversible | Maglietti et al · European Journal of Cancer | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Gen Elektrotransferi (Plazmid DNA) | Immune checkpoint inhibitor Programmed Death Ligand 1 (PD-L1) is upregulated in many malignancies which often correlates with unfavorable prognosis. PD-L1 on cancer cells can induce an “exha… |
| Reversible | Dolinsek et al · Cancers (Basel) | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Endoglin overexpression is associated with highly proliferative tumor endothelium and also with some tumors, including melanoma. Its targeting has anti-tumor effectiveness, which can also be… |
| Reversible | Forde · Gene Ther | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Antitumour efficacy of electroporated pEEV, coding for granulocyte-macrophage colony-stimulating factor and the B7-1 costimulatory immune molecule (pEEVGmCSF-b7.1) in growing solid tumours, … |
| Reversible | Forde · Cancer Gene Ther | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Regulatory T cells (T-regs) can negatively impact tumor antigen-specific immune responses after infiltration into tumor tissue. However, depletion of T-regs can facilitate enhanced anti-tumo… |
| Reversible | Shirley et al · Curr Gene Ther | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Effective delivery still remains a major hurdle in the development of gene based therapies. While technological advances have occurred that have improved delivery in general, there is still … |
| Reversible | Daeschlein et al · Exp Dermatol | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | The study was undertaken to compare antitumor efficacy of electrochemotherapy (ECT) with cold plasma therapy (CP) in a melanoma mouse model. After melanoma implantation into the flank of C57… |
| Reversible | Gerlini et al · Oncoimmunology | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Combining electrochemotherapy with dendritic cell-based immunotherapy is a promising strategy against human metastatic melanoma that deserves to be clinically assessed. While electrochemothe… |
| Reversible | Beebe et al · Cancers (Basel) | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Gen Elektrotransferi (Plazmid DNA) | Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cyto… |
| Reversible | Lladser et al · Cancer Immunol Immunother | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large variety of tumors and also in tumor associated endothelial cells but mostly absent in differentiate… |
| Reversible | Kang et al · Cancer Lett | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Electroporation is a useful means for non-viral gene delivery. Here, we investigated the use of electroporation to deliver polymer-DNA complexes into living cells using a protein kinase C (P… |
| Reversible | Spugnini et al · Microsc Res Tech | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Electroporation (EP) has been widely employed in the past years as a safe and effective technique to drive drugs and DNA plasmids into target cells both for experimental and therapeutic purp… |
| Reversible | Nuccitelli et al · Biochem Biophys Res Commun | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF) | We have discovered a new, drug-free therapy for treating solid skin tumors. Pulsed electric fields greater than 20 kV/cm with rise times of 30 ns and durations of 300 ns penetrate into the i… |
| Reversible | Snoj et al · European Journal of Cancer Supplements | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | The optimal treatment of multiple cutaneous and subcutaneous metastases of melanoma still remains unresolved. There are many different possible treatment modalities. We present a case of mel… |
| Reversible | Ayyavoo et al · Molecular Therapy | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu | Melanoma is an aggressive form of skin cancer. Effective treatment of this disease requires the development of new therapeutic strategies. One promising strategy is treatment of the tumor wi… |
| Reversible | Entin et al · Clin Cancer Res | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | Purpose: The exposure of cells in vitro to trains of low voltage-pulsed electric fields in the range of 20-100 V/cm was previously shown to induce an efficient uptake of macromolecules with … |
| Reversible | Heller et al · Melanoma Res | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | – | When cancer cells, including melanoma cells, are genetically altered to secrete cytokines, irradiated and injected into subjects, long-term antitumour immunity is induced. Optimally, existin… |
| Reversible | Heller et al · Melanoma Res | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | Electrochemotherapy (ECT), chemotherapy administered in combination with electric fields, has the potential to be an effective localized treatment for cutaneous malignancies. Bleomycin's cyt… |
| İrreversible | Vallin · Bioeng Transl Med | 2026 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a focal ablative cancer therapy that destroys cells through membrane destabilization via pulsed electric fields. It also has the capacity to induce a sy… |
| Reversible | Heinzelmann et al · J Clin Med | 2023 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | Background: Conjunctival melanoma (CM) is associated with a high rate of local recurrence and poor survival rate. Novel therapeutic options are needed to reduce recurrence rate. The objectiv… |
| Reversible | Fiorentzis et al · Biomedicines | 2020 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | Three-dimensional (3D) cell cultures represent small avascular tumors in vitro and simulate some of the biological characteristics of solid tumors, enhancing the evaluation of anticancer dru… |
| İrreversible | Szlasa et al · Molecules | 2020 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Mitokondriyal Disfonksiyon ve Oksidatif Stres | Irreversible electroporation (IRE) is today used as an alternative to surgery for the excision of cancer lesions. This study aimed to investigate the oxidative and cytotoxic effects the cell… |
| Reversible | Fiorentzis et al · Acta Ophthalmol | 2019 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması | Purpose: To investigate the cytotoxic effect of bleomycin, mitomycin C (MMC) and Fluorouracil (5-FU) in combination with electroporation (EP) on human conjunctival melanoma (CM) and normal c… |
| Reversible | Fiorentzis et al · Neoplasma | 2018 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) enhances responsiveness to cytotoxic drugs in numerous cell lines in vitro. Clinically ECT is widely applied for skin tumor ablation and has shown efficacy in treat… |
| Reversible | Kulbacka et al · Cell Stress Chaperones | 2013 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres | Two porphyrins, CoTPPS and MnTMPyPCl5, were tested for their photodynamic activity and potential novel use in a therapy of human cancers. We investigated an effect of photodynamic reaction (… |
| Reversible | Todorovic et al · Radiol Oncol | 2012 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması | Background: Electrochemotherapy is a local treatment combining chemotherapy and electroporation and is highly effective treatment approach for subcutaneous tumours of various histologies. Co… |
| Reversible | Mlakar et al · BMC Cancer | 2009 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Apoptoz İndüksiyonu | Background: Electroporation is a versatile method for in vitro or in vivo delivery of different molecules into cells. However, no study so far has analysed the effects of electric pulses use… |
| Reversible | Fania et al · Discov Oncol | 2021 | Anket / Saha Araştırması | İnsan | – | Non-melanoma skin cancers include basal and squamous cell carcinoma. These tumors have become an important health issue for their high incidence and for the morbidity, especially if untreate… |
| Reversible | Molina-Pineda et al · – | 2026 | Ön Baskı | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background/Objectives: Melanoma affects both sexes, and its incidence has increased in recent years. It is currently among the most common types of cancer. Standard chemotherapy, although ef… |
| Reversible | Perusseau-Lambert et al · Cureus | 2025 | Editöryal / Mektup | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Skin malignancies such as basal cell carcinoma, squamous cell carcinoma, and melanoma are increasingly prevalent in the UK, particularly among frail and elderly patients who are often unsuit… |
| Reversible | Choromańska et al · Adv Clin Exp Med | 2023 | Editöryal / Mektup | İnsan | Bleomisin Hücre İçi Birikiminin Artması | The cell membrane can be permeabilized when subjected to calibrated short electric pulses. This membrane alteration can be reversible, leaving cell viability unaffected. This set of events i… |
| Reversible | Giraud et al · Int J Radiat Oncol Biol Phys | 1996 | Editöryal / Mektup | İnsan | – | Infusional brachytherapy, the use of macroaggregated albumin and colloidal 32P in solid tumors, has been easy to reproduce in the clinic in Uppsala, Sweden; Brussels, Belgium; Seoul, Korea; … |
| Reversible | Campana et al · Eur J Surg Oncol | 2025 | Düzeltme / Erratum | – | – | European Journal of Surgical Oncology 51 (2025) 111158 Contents lists available at ScienceDirect European Journal of Surgical Oncology journal homepage: www.ejso.com Corrigendum to “Treatmen… |
| İrreversible | KURATA et al · JBSE | 2013 | Belirtilmemiş | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is attracting much attention as a less-invasive therapy to ablate abnormal tissues. With a pair of electrodes inserted into the tissue, the IRE perforates … |
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