Kemik ve Yumuşak Doku Sarkomları
Kas-İskelet ve SSS
Kemik metastazları ve yumuşak doku sarkomlarında elektrokemoterapi; ağrı palyasyonu, lokal kontrol ve cerrahi öncesi hacim küçültme amaçlarıyla çalışılmıştır. Kemik dokusunun yüksek empedansı ve elektrot yerleşiminin görüntüleme gerektirmesi alana özgü teknik başlıklardır.
59toplam yayın
18klinik çalışma
24preklinik çalışma
9derleme
1997–2026yayın aralığı
Rejime Göre Kanıt Durumu
Reversible elektroporasyon (RE-ECT)
49yayın
17klinik
20preklinik
Klinik Kanıt
1997–2026 · Rutin Klinik Kullanımda
İrreversible elektroporasyon (IRE-ECT)
10yayın
1klinik
4preklinik
Keşifsel Kanıt
2011–2023 · Erken Araştırma Aşamasında
Bu Alanda Raporlanan Mekanizmalar
Terimler, yayın özetleri üzerinde otomatik eşleştirmeyle saptanmıştır; rakam terimin geçtiği yayın sayısını gösterir.
Bleomisin Hücre İçi Birikiminin Artması 17
Reversible Membran Permeabilizasyonu 15
İrreversible Por Oluşumu ve Hücre Ölümü 13
Sisplatin Hücre İçi Birikiminin Artması 8
Elektrik Alan Dağılımı ve Modellemesi 8
Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu 7
Elektrot Geometrisi ve Yerleşimi 7
Nekroz ve Nekroptoz 5
Gen Elektrotransferi (Plazmid DNA) 3
Sistemik / Abskopal İmmün Yanıt 2
İnterlökin-12 Aracılı İmmün Uyarım 2
Doku İletkenliği ve Empedans Değişimi 2
Çalışma Tipi Dağılımı
Çubuk uzunluğu en kalabalık çalışma tipine göre ölçeklenmiştir; yüzde ise alanın tamamındaki payı verir. Renk, çalışma tipinin kanıt basamağını gösterir; kanıt haritasındaki ile aynı ölçek.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Prospektif Klinik Çalışma | 2 | %3 |
| Klinik Çalışma | 12 | %20 |
| Retrospektif Klinik Çalışma | 1 | %2 |
| Vaka Serisi | 3 | %5 |
| Vaka Raporu | 8 | %14 |
| Sistematik Derleme / Meta-Analiz | 1 | %2 |
| Derleme | 8 | %14 |
| Hayvan Çalışması | 21 | %36 |
| İn Vitro Çalışma | 1 | %2 |
| İn Siliko / Modelleme | 2 | %3 |
Literatür Kanıt Tablosu
59 yayın, kanıt gücü sırasına göre listelenmiştir. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Özet |
|---|---|---|---|---|---|---|
| Reversible | Ottlakan et al · Bioelectrochemistry | 2022 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | The aim of the current prospective pilot study exclusively for deep-seated soft tissue sarcomas (STS) was to evaluate efficacy and safety of bleomycin-based ECT using VEG (variable electrode… |
| Reversible | Cindrič et al · Technol Cancer Res Treat | 2018 | Prospektif Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | Vertebral column is the most frequent site for bone metastases. It has been demonstrated in previous studies that bone metastases can be efficiently treated by electrochemotherapy. We develo… |
| Reversible | Cevolani et al · J Surg Oncol | 2023 | Klinik Çalışma | İnsan | Nekroz ve Nekroptoz | Background: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment based on a high-voltage electric pulse combined with an anticanc… |
| Reversible | Campanacci et al · Curr Oncol | 2022 | Klinik Çalışma | İnsan | – | Bone metastases induce pain, risk of fracture, and neural compression, and reduced mobility and quality of life. Electrochemotherapy (ECT) is a minimally invasive local treatment based on a … |
| Reversible | Campanacci et al · Eur J Surg Oncol | 2021 | Klinik Çalışma | İnsan | – | Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in … |
| Reversible | Simioni et al · Sci Rep | 2020 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | Standard electrochemotherapy (ECT) is effective in many tumour types but is confined to the treatment of small superficial lesions. Variable electrode-geometry ECT (VEG-ECT) may overcome the… |
| Reversible | Sundararajan et al · JCPCR | 2019 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Volume 10 Issue 5 - 2019 Sarcomas are cancers that occur in soft tissues and bones that mostly affect teenagers and young adults. Although its occurrence is rare, the affect is huge-metastat… |
| Reversible | Bianchi et al · World J Surg | 2016 | Klinik Çalışma | İnsan | – | Introduction: Bone metastatic disease is a major cause of pain and decreased quality of life in patients with cancer. In addition to systemic therapy and pain control with narcotic analgesic… |
| Reversible | Guida et al · Annals of Oncology | 2016 | Klinik Çalışma | İnsan | – | Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, © The Author 2016. Published by Oxford … |
| Reversible | Guida et al · European Journal of Surgical Oncology (EJSO) | 2016 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Antivasküler Etki ve Damar Yıkımı | Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, which exerts prominent anti-tumour acti… |
| Reversible | Tosi et al · Med Biol Eng Comput | 2016 | Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi | Tissue electrical conductivity is correlated with tissue characteristics. In this work, some soft tissue sarcomas (STS) excised from patients have been evaluated in terms of histological cha… |
| Reversible | Campana et al · World J Surg | 2013 | Klinik Çalışma | İnsan | Elektrot Geometrisi ve Yerleşimi, Bleomisin Hücre İçi Birikiminin Artması | Aims: Our aim was to evaluate the activity, toxicity, and feasibility of electrochemotherapy (ECT) in patients with soft-tissue sarcomas (STS). Methods: A two-stage phase II trial was conduc… |
| Reversible | Shimizu et al · J Orthop Sci | 2003 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | Electrochemotherapy (ECT) delivers nonpermeable anticancer drugs to cell interiors by temporally increasing the permeability of the cytoplasmic membrane under locally applied pulsating elect… |
| Reversible | M Hyacinthe, M Jaroszeski, V Dang, D Coppola, R Karl, R Gilbert · Cancer | 1999 | Klinik Çalışma | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Pulsed electric fields have been shown to increase the effectiveness of antineoplastic agents by temporarily increasing the permeability of cell membranes. This type of drug delivery is call… |
| Reversible | Czarnecka et al · Eur J Surg Oncol | 2026 | Retrospektif Klinik Çalışma | İnsan | – | Background: Clear cell sarcoma (CCS) is a rare subtype of soft tissue sarcoma (STS). The objective of this analysis was to evaluate the effectiveness of multidisciplinary treatment of CCS an… |
| Reversible | Tedesco et al · J Clin Med | 2024 | Vaka Serisi | İnsan | Bleomisin Hücre İçi Birikiminin Artması | (1) Background: this case series and literature review aims to evaluate the efficacy and safety of electrochemotherapy in the management of aggressive spinal hemangiomas, presenting two dist… |
| Reversible | Deschamps et al · Eur J Cancer | 2023 | Vaka Serisi | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Objective: To report efficacy and safety of percutaneous electrochemotherapy (ECT) in patients with radiotherapy-resistant metastatic epidural spinal cord compression (MESCC). Material/ meth… |
| İrreversible | Martin et al · BMC Cancer | 2014 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Irreversible electroporation (IRE) has recently been added as an additional therapeutic ablative option in patients with locally advanced cancers (LAC) involving vital structures… |
| Reversible | Siew et al · Cardiovasc Intervent Radiol | 2026 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu, Elektrot Geometrisi ve Yerleşimi | Vertebral haemangiomas are benign lesions that developed from vascular proliferation within bone marrow spaces [1]. As these malformations do not grow by mitotic activity and lack any malign… |
| Reversible | Angelini et al · Diagnostics (Basel) | 2024 | Vaka Raporu | İnsan | Nekroz ve Nekroptoz | Metastases are complications of primary tumors due to prolonged cancer survival and have become an important issue for oncological patients and the most frequent cause of death and disabilit… |
| Reversible | Albertini et al · Case Rep Med | 2020 | Vaka Raporu | İnsan | – | Introduction Metastatic bone disease represents a systemic pathology that heavily affects the quality of life of oncologic patients causing pain and functional disability. Methodology . We p… |
| Reversible | Cornelis et al · Cardiovasc Intervent Radiol | 2019 | Vaka Raporu | İnsan | – | Two patients underwent percutaneous image-guided electrochemotherapy on blastic spine metastases involving posterior walls of the lumbar vertebral bodies with epidural extension. These treat… |
| İrreversible | Qin et al · Technol Cancer Res Treat | 2017 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose: To explore the safety and efficacy of irreversible electroporation ablation in unresectable fibrous sarcoma with 2 electrodes. Methods: A 74-year-old woman with unresectable retrope… |
| İrreversible | Steinbrecher et al · BMJ Case Rep | 2016 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Ewing's sarcoma (ES) is the second most common paediatric cancer of the bone. Standard therapy includes surgery or radiation for local control of primary and relapsed lesions and chemotherap… |
| Reversible | Bonadies et al · Anticancer Res | 2015 | Vaka Raporu | İnsan | – | Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous sarcoma with high recurrence rate. Radical surgery is the treatment of choice, although in cosmetically-sensitive areas such a… |
| İrreversible | Neal et al · J Clin Oncol | 2011 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a promising technique for the focal treatment of pathologic tissues that involves placing minimally invasive electrodes within the targeted region. A se… |
| Reversible | Bocchi et al · J Clin Med | 2023 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | Background and aim: Cancers are one of the most frequent causes of death and disability in humans. Skeletal involvement has a major impact on the quality of life and prognosis of cancer pati… |
| Reversible | Deschamps et al · Br J Radiol | 2025 | Derleme | İnsan | Elektrik Alan Dağılımı ve Modellemesi | This review aims to analyse the safety and clinical efficacy in terms of pain relief and local tumour control, in patients with metastatic epidural spinal cord compression undergoing electro… |
| Reversible | Berry-Kilgour · Front Bioeng Biotechnol | 2024 | Derleme | Literatür Analizi | Ekstraselüler Matriks ve Doku İskeletinin Korunması, Elektrik Alan Dağılımı ve Modellemesi | Tissue engineering encompasses a range of techniques that direct the growth of cells into a living tissue construct for regenerative medicine applications, disease models, drug discovery, an… |
| Reversible | Martin et al · Bioengineering (Basel) | 2023 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması | The primary aim of this study was to analyze studies that use electrochemotherapy (ECT) in "deep-seated" tumors in solid organs (liver, kidney, bone metastasis, pancreas, and abdomen) and un… |
| İrreversible | Sun et al · Anticancer Res | 2023 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Osteosarcoma is the most common primary bone malignancy, and surgical resection combined with neoadjuvant chemotherapy is the gold-standard treatment for affected patients. Although the over… |
| Reversible | Tsukamoto et al · Curr Oncol | 2021 | Derleme | İnsan | – | The number of patients with bone metastasis increases as medical management and surgery improve the overall survival of patients with cancer. Bone metastasis can cause skeletal complications… |
| İrreversible | Vailas et al · J BUON | 2019 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Sarcomas arise from uncontrolled cell growth in tissues of mesodermal origins, such as connective tissue, bone, cartilage, fat or muscle. Surgical resection is still considered the cornersto… |
| Reversible | Mavrogenis et al · Clin J Pain | 2016 | Derleme | İnsan | – | Background: Metastatic disease is the most common malignancy of the bone. Prostate, breast, lung, kidney, and thyroid cancer account for 80% of skeletal metastases. Bone metastases are assoc… |
| Reversible | Spugnini et al · Int J Biochem Cell Biol | 2008 | Derleme | Hayvan (İn Vivo) | – | Local management of soft tissue sarcoma in humans generally involves multi-modality approaches whose cornerstones are surgery combined with radiation therapy. The usual radiation protocols a… |
| Reversible | Ondráčková · Adv Sci (Weinh) | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi | Electrical lesioning of nervous tissue is a common surgical intervention and traditionally is carried out using high-amplitude high-frequency currents. These procedures ablate tissue via an … |
| Reversible | Deschamps et al · Eur Radiol Exp | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu | Background: Electrochemotherapy (ECT) of vertebral metastasis is a new treatment option for metastasis that is not accessible to thermal ablation or radiotherapy. A numerical feasibility stu… |
| Reversible | Müller et al · Sci Rep | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması, İrreversible Por Oluşumu ve Hücre Ölümü | Medical devices and technologies must undergo extensive testing and validation before being certified for public healthcare use, especially in oncology where a high research focus is on new … |
| Reversible | Kranjc et al · Radiol Oncol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | Background: Cisplatin is used in cancer therapy, but its side effects and acquired resistance to cisplatin have led to the synthesis and evaluation of new platinum compounds. Recently, the s… |
| Reversible | Tschon et al · Technol Cancer Res Treat | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Skeletal metastases are a common cause of severe morbidity, reduction in quality of life and often early mortality. Consequently, improvements in therapies are necessary. Electroporation use… |
| İrreversible | Tam et al · Radiology | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | Purpose To determine the effects of irreversible electroporation (IRE) on the neural tissues after ablation in the epidural space of the porcine spine. Materials and Methods The institutiona… |
| Reversible | Cemazar et al · Radiol Oncol | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background: Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their … |
| İrreversible | Song et al · Sci Rep | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a novel ablation method that has been tested in humans with lung, prostate, kidney, liver, lymph node and presacral cancers. As a new non-thermal treatm… |
| Reversible | Fini et al · Clin Exp Metastasis | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Bone metastases impair general health status, quality of life and survival of patients. Electrochemotherapy (ECT), which combines electroporation (EP) and the administration of anticancer dr… |
| Reversible | Sedlar · BMC Cancer | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | Background: Interleukin-12 (IL-12) based radiosensitization is an effective way of tumor treatment. Local cytokine production, without systemic shedding, might provide clinical benefit in ra… |
| Reversible | Sedlar et al · Radiol Oncol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | BACKGROUND.: Electrochemotherapy provides good local tumor control but requires adjuvant treatment for increased local response and action on distant metastasis. In relation to this, intramu… |
| İrreversible | Li et al · PLoS One | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Irreversible electroporation (IRE) is a promising technique for the focal treatment of pathologic tissues, which involves placing minimally invasive electrodes within the targete… |
| Reversible | Spugnini et al · J Transl Med | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | Background: Cancer is one of the most difficult current health challenges, being responsible for millions of deaths yearly. Systemic chemotherapy is the most common therapeutic approach, and… |
| Reversible | Fini et al · J Bone Joint Surg Br | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Short intense electrical pulses transiently increase the permeability of the cell membrane, an effect known as electroporation. This can be combined with antiblastic drugs for ablation of tu… |
| Reversible | Grosel et al · DNA Cell Biol | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Sisplatin Hücre İçi Birikiminin Artması | The aim of our study was to evaluate feasibility and therapeutic potential of electrogene therapy with p53 alone or combined with electrochemotherapy using cisplatin on two murine sarcomas w… |
| Reversible | Spugnini et al · Cancer Chemother Pharmacol | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Feline soft tissue sarcomas are spontaneous, rapidly growing, and aggressive neoplasms that mimic their human counterpart. The purpose of this study was to evaluate the feasibility and effic… |
| Reversible | Kranjc et al · BMC Cancer | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background: Bleomycin is poorly permeant but potent cytotoxic and radiosensitizing drug. The aim of the study was to evaluate whether a physical drug delivery system - electroporation can in… |
| Reversible | Isobe et al · Clin Orthop Relat Res | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Methotrexate plays a key role in adjuvant chemotherapy for treatment of osteosarcoma, but is used at a high dose because it can pass through a cell membrane only with difficulty. Therefore, … |
| Reversible | Jaroszeski et al · Technol Cancer Res Treat | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | Electrochemotherapy is the combined use of a chemotherapeutic agent and pulsed electric fields. Electrical treatment causes an increase in cell membrane permeability which allows the chemoth… |
| Reversible | A Horiuchi, T Nikaido, J Mitsushita, T Toki, I Konishi, S Fujii · International Journal of Cancer | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sistemik / Abskopal İmmün Yanıt | Int. J. Cancer: 88, 640 – 644 (2000) © 2000 Wiley-Liss, Inc. Publication of the International Union Against Cancer ENHANCEMENT OF ANTITUMOR EFFECT OF BLEOMYCIN BY LOW-VOLTAGE IN VIVO ELECTRO… |
| Reversible | Sersˇa et al · Bioelectrochemistry and Bioenergetics | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy combines chemotherapy with electric pulses in order to potentiate anti-tumor effectiveness of chemotherapeutic drugs. Electrochemotherapy with drugs that normally do not … |
| İrreversible | Gill et al · Oncotarget | 2018 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması | Background: Osteosarcoma accounts for roughly 60% of all malignant bone tumors in children and young adults. The five-year survival rate for localized tumors after surgery and chemotherapy i… |
| Reversible | Cindrič et al · Cancers (Basel) | 2022 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Electroporation-based treatments such as electrochemotherapy and irreversible electroporation ablation have sparked interest with respect to their use in medicine. Treatment planning involve… |
| Reversible | Ongaro et al · Technol Cancer Res Treat | 2015 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | Electrochemotherapy (ECT) is a local anticancer treatment based on the combination of chemotherapy and short, tumor-permeabilizing, voltage pulses delivered using needle electrodes or plate … |
Sınırlılıklar
Bu sayfadaki sayımlar kaynak PDF arşivinin kapsamıyla sınırlıdır ve alanın literatürünün sistematik bir taraması değildir. Çalışma tipi ve mekanizma etiketleri otomatik türetilmiştir; kritik kararlar için tablodaki yayınların tam metinlerine başvurulmalıdır. Kanıt düzeyi etiketi yayın sayısına dayanır, yayınların metodolojik kalitesine değil.