Grup: Derin Organ Tümörleri
Karaciğer Tümörleri
Karaciğer, elektroporasyonun her iki rejiminin de çalışıldığı bir organdır. Büyük damarlara ve safra yollarına komşu lezyonlarda termal ablasyonun ısı yayılımı sorun oluşturur; elektroporasyon, bu yapıların matriks iskeletini koruduğu gerekçesiyle literatürde alternatif olarak değerlendirilir.
Klinik yayın: randomize, prospektif ve retrospektif çalışma, vaka serisi ve vaka raporu. Preklinik yayın: hayvan, in vitro, modelleme ve deneysel biyofizik çalışmaları.
Bu Alanda Sağlık Teknolojisi Değerlendirmeleri
Bu portal literatürün hacmini sayar; bir işlemin etkili olup olmadığını değerlendirmez. Aşağıdaki kurumlar bu değerlendirmeyi yapar ve sonuçları literatürün hacminden bağımsızdır: geniş bir literatür, kanıtın yeterli bulunduğu anlamına gelmez.
- LBI-HTA · 2019 · Karaciğer ve pankreas kanserinde IRE
- NICE · 2019 · Primer karaciğer kanserinde IRE (HealthTech htg532, eski IPG444-IPG664)
- ACIS_avalia-t · 2014 · Pankreas ve karaciğer kanserinde IRE
- NICE · 2013 · Karaciğer metastazlarında IRE (HealthTech htg304, eski IPG445)
Belgelerin tamamı ve künyeleri Düzenleyici Belgeler sayfasındadır. Portal bu raporların sonucunu kendi adına yorumlamaz; güncel karar için ilgili kurumun kendi yayınına bakınız.
Yayınların Bildirdiği Klinik ve Teknik Veriler
Bu alandaki 291 yayının tam metninde bildirilen alanların toplamı. Sayılar toplanır, yorumlanmaz.
Toplamlar benzersiz hasta sayısı değildir: aynı kohort birden fazla yayında raporlanmış olabilir.
Yönteme Göre Literatür Durumu
Klinik yöntem başına yayın sayısı, klinik ve preklinik dağılım, literatür hacmi ve yayın aralığı. Sayfa girişindeki rozetler IRE ve ECT kayıtlarını ayrı ayrı özetler; yöntem ayrımının tamamı buradadır.
Elektrokemoterapi (ECT)
Sınırlı klinik yayın hacmieşik 13/47 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 9, preklinik 1.
1997–2025
İrreversible elektroporasyon (IRE)
Yüksek klinik yayın hacmieşik 60/203 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 47, preklinik 3.
2006–2026
Kalsiyum elektroporasyonu
Keşifsel / düşük hacimli literatüreşik 0/1 kayıt
Bu yöntemin hiçbir kaydı hacim etiketine girmemiştir.
2024–2024
Gen elektrotransferi
Keşifsel / düşük hacimli literatüreşik 0/2 kayıt
Bu yöntemin hiçbir kaydı hacim etiketine girmemiştir.
2008–2026
Diğer elektroporasyon uygulamaları
Bu küme tek bir klinik yöntemi adlandırmaz; literatür hacmi atanmaz.
2007–2026
Yöntemi belirlenmemiş kayıtlar
Bu küme tek bir klinik yöntemi adlandırmaz; literatür hacmi atanmaz.
2026–2026
Özetlerde Anılan Mekanizmalar
Rakam, mekanizma adının geçtiği özet sayısıdır. Bir mekanizmanın anılması, o çalışmada gösterildiği anlamına gelmez.
Çalışma Tipi Dağılımı
Yüzde, alanın tamamındaki payı verir.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Randomize Klinik Çalışma | 2 | <%1 |
| Prospektif Klinik Çalışma | 16 | %5 |
| Klinik Çalışma | 42 | %14 |
| Retrospektif Klinik Çalışma | 33 | %11 |
| Vaka Serisi | 11 | %4 |
| Vaka Raporu | 18 | %6 |
| Sistematik Derleme / Meta-Analiz | 10 | %3 |
| Kılavuz / Uzlaşı | 2 | <%1 |
| Derleme | 33 | %11 |
| Hayvan Çalışması | 88 | %30 |
| İn Vitro Çalışma | 12 | %4 |
| İn Siliko / Modelleme | 13 | %4 |
| Teknik / Cihaz Çalışması | 2 | <%1 |
| Deneysel Biyofizik Çalışması | 1 | <%1 |
| Kongre Özeti | 2 | <%1 |
| Editöryal / Mektup | 3 | %1 |
| Belirtilmemiş | 1 | <%1 |
| Protokol | 2 | <%1 |
Yayın Tablosu
291 yayın kaydı, çalışma tasarımına göre sıralanmıştır. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
Sınıflandırmalar otomatik üretilir ve tekil kayıtlarda hata içerebilir. Metodoloji
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Hasta / lezyon | Cihaz | Ajan ve yol | Bildirilen sonuç | Özet |
|---|---|---|---|---|---|---|---|---|---|---|
| IRE | Zhang · Front Oncol | 2022 | Randomize Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 152 | Intelligent Health Medical Co., Ltd IRE-based ablation thera, NanoKnife | – | genel sağkalım 88.16% (76 hasta) | Irreversible electroporation (IRE) is a soft tissue ablation technique that uses short electrical fields which induce the death of target cells. To evaluate the safety and efficacy of an IRE… |
| IRE | Yang et al · Cardiovasc Intervent Radiol | 2018 | Randomize Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 40 | – | – | nesnel yanıt 68.2% (22 hasta) | Purpose: This study aimed to investigate the safety and short-term efficacy of irreversible electroporation (IRE) combined with allogenic natural killer (NK) cell immunotherapy in the treatm… |
| IRE | Liu et al · Int J Med Sci | 2026 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 35 | NanoKnife, Covidien 11c RF generator, StarBurst XL expandable electrodes | – | nesnel yanıt 36.4% (11 hasta) | Background: To evaluate the short- to intermediate-term radiological evolution of ablation zones using contrast-enhanced MRI and to assess clinically relevant outcomes following irreversible… |
| IRE | Ma et al · J Clin Transl Hepatol | 2022 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 26 / 39 | NanoKnife | – | tam yanıt 92.3% (39 lezyon) | Background and aims: Irreversible electroporation (IRE) is an emerging local ablation therapy which may be effective for unresectable tumors. This study aimed to evaluate the safety and effi… |
| ECT | Djokic et al · Cancers (Basel) | 2020 | Prospektif Klinik Çalışma | İnsan | – | 24 / 32 | Cliniporator VITAE, Cliniporator | bleomisin · intravenöz | tam yanıt 84.4% (32 lezyon) | The aim of this clinical study was to investigate the effectiveness and long-term safety of electrochemotherapy as an emerging treatment for HCC in patients not suitable for other treatment … |
| ECT | Edhemovic et al · Eur J Surg Oncol | 2020 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 39 / 84 | Cliniporator VITAE, Cliniporator | bleomisin · intravenöz | – | Background and objectives: A previous pilot study proved the feasibility, safety and efficacy of electrochemotherapy in the treatment of colorectal liver metastases. The aim of this study wa… |
| IRE | Zhou · World J Surg Oncol | 2020 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 21 / 24 | NanoKnife | – | tam yanıt 79.17% (24 lezyon) | Background: Familiarity with post-IRE imaging interpretation is of considerable importance in determining ablation success and detecting recurrence. CEUS can be used to assess the tumour res… |
| ECT | Cornelis et al · Diagn Interv Imaging | 2019 | Prospektif Klinik Çalışma | İnsan | – | 1 / 1 | Cliniporator VITAE | bleomisin · intravenöz | tam yanıt 1 gün (1 hasta) | Bu yayında özet bulunmuyor. |
| ECT | Djokic et al · Eur J Surg Oncol | 2018 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Bleomisin Hücre İçi Birikiminin Artması | 10 / 17 | IGEA SpA, IGEA SpA electric pulse generator | bleomisin · intravenöz | tam yanıt 88% (17 lezyon) | Background and objectives: Electrochemotherapy provides non-thermal ablation of cutaneous as well as deep seated tumors. Based on positive results of the treatment of colorectal liver metast… |
| ECT | Gasljevic et al · PLoS One | 2017 | Prospektif Klinik Çalışma | İnsan | Nekroz ve Nekroptoz | 7 / 13 | Cliniporator | bleomisin · intravenöz | – | Electrochemotherapy of colorectal liver metastases has been proven to be feasible, safe and effective in a phase I/II study. In that study, a specific group of patients underwent two-stage o… |
| IRE | Beyer et al · PeerJ | 2016 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 20 / 20 | NanoKnife | – | tam yanıt 100% (10 hasta) | Purpose. The purpose of this study was to compare CT-navigated stereotactic IRE (SIRE) needle placement to non-navigated conventional IRE (CIRE) for percutaneous ablation of liver malignanci… |
| IRE | Niessen et al · J Vasc Interv Radiol | 2016 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 34 / 65 | NanoKnife | – | tam yanıt 86.6% | Purpose: To evaluate the safety and efficacy of percutaneous irreversible electroporation (IRE) of primary and secondary liver cancer unsuitable for resection or thermal ablation. Materials … |
| IRE | Niessen et al · J Vasc Interv Radiol | 2015 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 25 / 48 | NanoKnife | – | lokal nüks 14 adet (48 lezyon) | Purpose: To evaluate the risk factors associated with short-term local recurrence of malignant liver lesions after irreversible electroporation (IRE). Materials and methods: Thirty-nine cons… |
| IRE | Sugimoto et al · Jpn J Radiol | 2015 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 5 / 6 | NanoKnife | – | lokal nüks 0.833 oran (6 lezyon) | Purpose: This clinical study was conducted to evaluate the safety and short-term outcomes of irreversible electroporation (IRE) for the treatment of patients with hepatocellular carcinoma (H… |
| ECT | Edhemovic et al · J Surg Oncol | 2014 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | 16 / 29 | IGEA SpA, IGEA SpA electric pulse generator | bleomisin · intravenöz | tam yanıt 85% (27 lezyon) | Background and objectives: Electrochemotherapy is effective in treatment of various cutaneous tumors and could be translated into treatment of deep-seated tumors. With this aim a prospective… |
| IRE | Scheffer et al · Eur Radiol | 2014 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 10 / 10 | NanoKnife | – | – | Objectives: Irreversible electroporation (IRE) is a new ablation technique that relies on high-voltage electrical pulses. This clinical study evaluates the pathological response of colorecta… |
| IRE | Cannon et al · J Surg Oncol | 2012 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 44 | NanoKnife | – | lokal nüks 97.4% | Introduction: Irreversible electroporation (IRE) has shown promise for ablation of lesions in proximity to vital structures in the preclinical setting. This study aims to evaluate the safety… |
| IRE | Wiggermann et al · Clin Hemorheol Microcirc | 2012 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 15 / 15 | NanoKnife | – | – | Purpose: The aim of this study is to describe the image findings of contrast-enhanced ultrasound (CEUS) after irreversible electroporation (IRE), and to assess its usefulness in relation to … |
| Diğer EP | Berman et al · J Vasc Interv Radiol | 2026 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 54 / 57 | Epione robotic device, Epione | – | lokal kontrol 93.6% (94 lezyon) | Purpose: To report initial experience and learning curve with robotic-assisted percutaneous ablations of abdominal lesions. Materials and methods: Fifty-four consecutive patients undergoing … |
| IRE | Xu et al · JHEP Rep | 2026 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 315 | PoriNova System, nsPEF System | – | genel sağkalım 89% (329 hasta) | Background & aims: Irreversible electroporation (IRE) and stereotactic body radiotherapy (SBRT) are important therapeutic alternatives for hepatocellular carcinoma (HCC) unsuitable for therm… |
| ECT | Wilke et al · Radiol Oncol | 2025 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 44 / 52 | Cliniporator | bleomisin · intravenöz | tam yanıt 61.9% (21 lezyon) | Background: Electrochemotherapy (ECT) is a local nonsurgical effective tumor treatment in the hand of the clinician for the treatment of patients with liver tumors or metastases. The study a… |
| IRE | Sutter et al · Phys Med Biol | 2025 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 22 / 23 | NanoKnife | – | – | Objective. To correlate numerical simulations of the electric dose distribution with early post-operative MRI following irreversible electroporation (IRE) treatment of hepatocellular carcino… |
| IRE | Zhao · BMC Cancer | 2025 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 12 | YTL-GM01 | – | lokal kontrol 91.7% (12 hasta) | Objectives: This study aimed to assess the effectiveness and safety of conventional transarterial chemoembolization (c-TACE) followed by irreversible electroporation (IRE) for the treatment … |
| IRE | Narayanan · Cardiovasc Intervent Radiol | 2024 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 14 / 47 | NanoKnife | – | – | Purpose: Hepatic epithelioid hemangioendothelioma (HEHE) is a rare tumor with currently no established standard of care. This international multicenter retrospective study assesses the use o… |
| ECT | Kovács et al · J Pers Med | 2022 | Klinik Çalışma | İnsan | – | 155 / 21 | Cliniporator VITAE | bleomisin · intravenöz | lokal kontrol 81% (21 lezyon) | Purpose: To evaluate local tumour control (LTC) by local ablation techniques (LAT) in liver malignancies. Materials and methods: In patients treated with LAT between January 2013 and October… |
| IRE | Bäumler · Diagnostics (Basel) | 2022 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 54 | NanoKnife, Acculis Microwave Tissue Ablation, Emprint Ablation System | – | lokal kontrol 85.2% (27 hasta) | Early detection of local tumor progression (LTP) after irreversible electroporation (IRE) and microwave ablation (MWA) of hepatocellular carcinoma (HCC) remains challenging. The goal of this… |
| IRE | Hitpass · Cardiovasc Intervent Radiol | 2022 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 23 / 32 | NanoKnife | – | tam yanıt 95.6% (23 hasta) | Purpose: To examine the safety and short-term oncologic outcomes of computer-tomography-guided (CT-guided) irreversible electroporation (IRE) of recurrent, irresectable colorectal liver meta… |
| IRE | Jarm et al · Biomed Eng Online | 2020 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | Cliniporator VITAE | diğer · hem intravenöz hem intratümöral | – | Background: The effectiveness of electrochemotherapy of tumors (ECT) and of irreversible electroporation ablation (IRE) depends on different mechanisms and delivery protocols. Both therapies… |
| IRE | Tamura et al · J Vasc Interv Radiol | 2020 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 39 / 45 | NanoKnife | – | genel sağkalım 26.6% (64 lezyon) | Purpose: To examine predictors of midterm occlusion in portal and hepatic veins within or adjacent to the ablation zone after irreversible electroporation (IRE) of liver tumors. Materials an… |
| IRE | Wang et al · J Interv Med | 2020 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 18 / 22 | AngioDynamics IRE device | – | tam yanıt 90.1 oran (22 lezyon) | Objectives: To preliminarily evaluate the clinical effectiveness and safety of computed tomography (CT) image-guided irreversible electroporation (IRE) for the treatment of recurrent hepatoc… |
| IRE | Bäumler et al · Cancer Manag Res | 2020 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 45 / 62 | NanoNife | – | kanama kontrolü 32 adet (80 hasta) | Purpose: To assess the incidence and evolution of biliary alterations adjacent to the ablation area in patients with hepatic malignancies during the first 3 months after percutaneous irrever… |
| IRE | Chai et al · Ultrasound Med Biol | 2020 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 19 / 21 | NanoKnife | – | – | The aim of this study was to describe ultrasound (US) and contrast-enhanced ultrasound (CEUS) findings immediately and 1 d after percutaneous irreversible electroporation (IRE) of hepatic ma… |
| IRE | Bäumler et al · Sci Rep | 2019 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 87 / 112 | NanoNife | – | – | The incidence and evolution of venous thrombosis adjacent to the ablation zone after percutaneous irreversible electroporation (IRE) were evaluated to identify potential risk factors in pati… |
| IRE | Jiang et al · Exp Ther Med | 2019 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 3 / 3 | NanoKnife | – | – | Metastatic retroperitoneal tumors constitute an end-stage disease with poor prognosis that represents a heavy global health burden. The present study aimed to explore the efficacy of irrever… |
| IRE | Rennert et al · J Gastrointestin Liver Dis | 2019 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 68 | NanoKnife | – | tam yanıt 53 adet (68 lezyon) | Aim: Evaluation of the post-interventional success following irreversible electroporation (IRE) using a new color coded perfusion quantification software with contrast-enhanced ultrasound (C… |
| IRE | Sugimoto et al · J Vasc Interv Radiol | 2019 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 21 | NanoKnife | – | – | Purpose: Irreversible electroporation (IRE) differs from thermal radiofrequency (RF) ablation, especially in terms of the reparative process in the ablation zone induced. To elucidate this, … |
| ECT | Boc et al · Radiol Oncol | 2018 | Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator | bleomisin | – | Background The aim of the study was to characterize ultrasonographic (US) findings during and after electrochem-otherapy of liver tumors to determine the actual ablation zone and to verify t… |
| IRE | Alnaggar et al · Cell Physiol Biochem | 2018 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 40 | – | – | genel sağkalım 10.1 ay (20 hasta) | Background/aims: We evaluated the clinical effectiveness of irreversible electroporation (IRE) in combination with immunotherapy using allogenic natural killer cells (NK) for stage IV hepato… |
| IRE | Ruarus et al · Cardiovasc Intervent Radiol | 2018 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Doku İletkenliği ve Empedans Değişimi | 30 / 30 | NanoKnife | – | lokal kontrol 24 adet (30 hasta) | Purpose: Irreversible electroporation (IRE) induces apoptosis with high-voltage electric pulses. Although the working mechanism is non-thermal, development of secondary Joule heating occurs.… |
| IRE | Scheck et al · Korean J Radiol | 2018 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 39 | NanoKnife, RF 3000 system, LeVeenTM | – | ablasyon hacmi 70.1% (20 lezyon) | Objective: To compare short-, mid-, and long-term follow-up ablation zone volume alterations as well as imaging features on contrast-enhanced computed tomography (CT) after irreversible elec… |
| ECT | Coletti et al · Int J Surg | 2017 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | 5 / 9 | Cliniporator | bleomisin · intravenöz | tam yanıt 55.5% (9 lezyon) | Background and objectives: Electrochemotherapy is a novel ablation technique combining chemotherapeutic agents with reversible cell membrane electroporation. Previous experiences have shown … |
| IRE | Distelmaier et al · Radiology | 2017 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 29 / 43 | NanoKnife | – | tam yanıt 93% (43 lezyon) | Purpose To investigate the efficacy and safety of irreversible electroporation (IRE) in the treatment of hepatic tumors not suitable for thermal ablation (radiofrequency ablation [RFA] or mi… |
| IRE | Frühling et al · Eur J Surg Oncol | 2017 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 30 / 38 | NanoKnife | – | ablasyon hacmi 78.9% (38 lezyon) | Introduction: A single-center nonrandomized clinical trial was performed to assess the safety and efficacy of IRE ablation of liver tumors in humans. Methods: 38 malignant liver tumors on 30… |
| IRE | Langan et al · J Surg Oncol | 2017 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 40 / 77 | NanoKnife | – | lokal nüks 13.4% (77 lezyon) | Background: Irreversible electroporation (IRE) has emerged as a novel, safe ablative therapy for peri-vascular lesions. However, there remains a paucity of data on long-term outcomes. Method… |
| IRE | Bhutiani et al · HPB (Oxford) | 2016 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 55 | NanoKnife, Microsulis 2450 Hz Microwave ablation system | – | ablasyon hacmi 100% (30 hasta) | Introduction: Few studies have assessed the tolerability and efficacy of irreversible electroporation (IRE) in the treatment of Child-Pugh B (7/8) patients with hepatocellular carcinoma (HCC… |
| IRE | Sugimoto et al · J Med Ultrason (2001) | 2016 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 16 / 21 | NanoKnife | – | – | Purpose: To assess the diagnostic accuracy of contrast-enhanced ultrasound (CEUS), contrast-enhanced multiphase CT (CECT), and gadoxetic acid-enhanced MRI (EOB-MRI) in identifying residual t… |
| IRE | Zeng et al · Technol Cancer Res Treat | 2016 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 14 | NanoKnife, AccuSyneR | – | tam yanıt 25% (8 hasta) | This study aimed to investigate the safety and effectiveness of irreversible electroporation ablation for unresectable large liver cancer. Fourteen patients were enrolled: 8 with large hepat… |
| IRE | Dollinger et al · J Vasc Interv Radiol | 2016 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 24 / 53 | NanoKnife | – | – | Purpose: To evaluate biliary complications after irreversible electroporation (IRE) of hepatic malignancies. Materials and methods: In 24 patients (17 men; mean age, 59.3 y), bile ducts were… |
| ECT | Mali et al · Biomed Eng Online | 2015 | Klinik Çalışma | İnsan | – | 16 | Cliniporator VITAE, VG1240, N-30-HG | bleomisin · intravenöz | ablasyon hacmi 0% (10 hasta) | Background: Electrochemotherapy (ECT) is a combined treatment in which high voltage electroporation (EP) pulses are used to facilitate the uptake of a chemotherapeutic drug into tumor cells,… |
| Diğer EP | Marčan et al · PLoS One | 2015 | Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electroporation-based treatments rely on increasing the permeability of the cell membrane by high voltage electric pulses applied to tissue via electrodes. To ensure that the whole tumor is … |
| IRE | Granata et al · Radiol Med | 2015 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 20 / 24 | NanoKnife | – | tam yanıt 91.7% (24 lezyon) | Objective: Irreversible electroporation (IRE) is a new ablation modality. Our purpose was to describe the effectiveness and the safety of the treatment and to evaluate the magnetic resonance… |
| IRE | Granata et al · AJR Am J Roentgenol | 2015 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 20 / 24 | NanoKnife | – | tam yanıt 22 adet (24 lezyon) | Objective: Irreversible electroporation is a new ablation modality. Our purpose was to describe the MRI findings after irreversible electroporation treatment of hepatocellular carcinoma (HCC… |
| IRE | Scheffer et al · BMC Cancer | 2015 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 29 | NanoKnife | – | – | Background: Irreversible electroporation (IRE) is a novel image-guided tumor ablation technique that has shown promise for the ablation of lesions in proximity to vital structures such as bl… |
| Diğer EP | Marcan et al · Radiol Oncol | 2014 | Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Introduction: Electroporation-based treatments rely on increasing the permeability of the cell membrane by high voltage electric pulses delivered to tissue via electrodes. To ensure that the… |
| IRE | Eller et al · Cardiovasc Intervent Radiol | 2014 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 14 / 18 | NanoKnife | – | lokal nüks 2 adet (12 hasta) | Purpose: This study was designed to assess efficacy and safety in the treatment of perivascular malignant liver lesions using percutaneous, computed tomography (CT)-guided irreversible elect… |
| IRE | Neal et al · Cardiovasc Intervent Radiol | 2014 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 22 | NanoKnife, T820 square wave generator | – | – | Introduction: Irreversible electroporation (IRE) ablation uses a series of brief electric pulses to create nanoscale defects in cell membranes, killing the cells. It has shown promise in num… |
| IRE | Cheung et al · Technol Cancer Res Treat | 2013 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | IRE System | – | – | The aims of this study were to evaluate the safety, feasibility and tumour response of _irreversible electroporation, a non-thermal ablation technique, for the treatment of unresectable hepa… |
| IRE | Neal II et al · JBiSE | 2012 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | prototype IRE generator | – | – | Therapeutic irreversible electroporation (IRE) is a relatively new technique for targeted tumor ablation. Needle electrodes are placed into or around the targeted region to deliver a series … |
| ECT | Edhemovic et al · Technol Cancer Res Treat | 2011 | Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | 1 / 1 | Cliniporator VITAE | bleomisin · intravenöz | tam yanıt 1 adet (1 lezyon) | Electrochemotherapy is now in development for treatment of deep-seated tumors, like in bones and internal organs, such as liver. The technology is available with a newly developed electric p… |
| IRE | Narayanan · Gastroenterol Hepatol (N Y) | 2011 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 100 | – | – | – | Govindarajan Narayanan, MD Chief of Vascular and Interventional Radiology Miller School of Medicine University of Miami Miami, Florida G&H How does the NanoKnife work? GN The NanoKnife (Angi… |
| IRE | Jouni · Technol Cancer Res Treat | 2025 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 10 | NanoKnife | – | ablasyon hacmi 34.79 cm³ | ObjectivesIrreversible Electroporation (IRE) is both open surgery and minimally invasive cancer therapy used in the treatment of liver tumors. The therapy demands precision and accuracy to e… |
| IRE | Narayanan et al · Cancers (Basel) | 2025 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 32 / 57 | Emprint; Neuwave; Solero, NanoKnife, Emprint Ablation System, Neuwave Ablation System, Solero Microwave Ablation System | – | tam yanıt 34 adet (57 lezyon) | Objectives : This single-center retrospective study evaluates the clinical efficacy and safety of percutaneous ablation using microwave ablation (MWA) and irreversible electroporation (IRE) … |
| IRE | Pescatori et al · Int J Hyperthermia | 2025 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 48 / 65 | NanoKnife | – | lokal kontrol 62% (65 lezyon) | Background: Irreversible electroporation (IRE) in hepatocellular carcinoma (HCC) triggers apoptosis instead of thermal coagulation, resulting in specific modifications within ablation zones.… |
| IRE | Wang et al · Acad Radiol | 2025 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 213 / 319 | IRE therapeutic apparatus from Hangzhou Ruidi Biotech Ltd. | – | lokal kontrol 6.2% (80 hasta) | Rationale and objectives: The therapeutic efficacy of irreversible electroporation (IRE) for treating subcapsular hepatocellular carcinoma (HCC) remains under-explored. The current study aim… |
| IRE | Xu et al · Eur Radiol | 2025 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 180 | NanoKnife, Ruidi Biotechnology nsPEF device, nsPEF device | – | lokal nüks 10.5% (180 hasta) | Objectives: Irreversible electroporation (IRE) is a relatively recent non-thermal ablation technique for hepatocellular carcinoma (HCC) in high-risk anatomical locations, but post-procedural… |
| ECT | Luerken et al · Biomedicines | 2024 | Retrospektif Klinik Çalışma | İnsan | – | 22 / 23 | Cliniporator, CAS-One IR | bleomisin · intravenöz | tam yanıt 95.7% (23 lezyon) | Background and Objectives : To report on the first results of safety, efficacy, and outcome of CT-navigated stereotactic percutaneous electrochemotherapy (SpECT) in patients with primary and… |
| IRE | Frühling et al · Eur J Surg Oncol | 2024 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 124 / 170 | NanoKnife | – | lokal nüks 6 ay (170 lezyon) | Introduction: A nationwide multicenter study was performed to examine whether there is a correlation between decrease in tissue resistance and time to local tumor recurrence after irreversib… |
| IRE | Gong · Front Oncol | 2024 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 32 / 39 | NanoKnife | – | genel sağkalım 571 gün (32 hasta) | Background: Irreversible electroporation has been proved as a feasible and safe method against tumor in liver. However, few studies focused on tumors adjacent to perihepatic important struct… |
| IRE | Narayanan et al · J Vasc Interv Radiol | 2024 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Sinir ve Damar Yapılarının Korunması | – | NanoKnife | – | – | Purpose: To evaluate the safety, effectiveness, and oncological outcomes of irreversible electroporation (IRE) of unresectable colorectal liver metastases (CRLMs) close to critical structure… |
| IRE | Zhang et al · Liver Int | 2024 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 633 | – | – | – | Objectives: This study aimed to develop a quantitative intratumoral heterogeneity (ITH) model for assessing the risk of early recurrence (ER) in pre-treatment multimodal imaging for hepatoce… |
| Diğer EP | Amygdalos · Langenbecks Arch Surg | 2023 | Retrospektif Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | NanoKnife | – | – | Purpose: Colorectal liver metastases (CRLM) are the predominant factor limiting survival in patients with colorectal cancer. Multimodal treatment strategies are frequently necessary to achie… |
| IRE | Frühling et al · Eur J Surg Oncol | 2023 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 149 / 206 | NanoKnife | – | lokal kontrol 58.3% (62 hasta) | Introduction: A nationwide multicenter study was performed to examine short- and long-term effects of irreversible electroporation (IRE) for hepatocellular carcinoma (HCC) and colorectal can… |
| IRE | Li et al · Curr Oncol | 2022 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 21 / 38 | NanoKnife | – | tam yanıt 100% (21 hasta) | Background: Tumors at the hepatocaval confluence are difficult to treat, either surgically or ablatively. Methods: A retrospective longitudinal study on patients ineligible for thermal ablat… |
| IRE | Freeman et al · Scand J Gastroenterol | 2021 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 99 / 174 | – | – | lokal nüks 10 adet (25 lezyon) | Background and aims: Irreversible electroporation (IRE) is a relatively new non-thermal ablative method for unresectable hepatocellular carcinoma (HCC). We aimed to compare the longer-term e… |
| IRE | Pan et al · Cancers (Basel) | 2021 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 9 / 11 | NanoKnife | – | lokal kontrol 0% (11 lezyon) | Introduction: To explore the feasibility, safety, and efficiency of ethiodized oil tumor marking combined with irreversible electroporation (IRE) for small hepatocellular carcinomas (HCCs) t… |
| IRE | Ridouani et al · Medicina (Kaunas) | 2021 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 44 / 44 | NanoKnife | – | ablasyon hacmi 241.04 mm (44 hasta) | Background and Objectives : To compare ablation zone involution following microwave ablation (MWA) or irreversible electroporation (IRE) of liver tumors. Materials and Methods : MWA or IRE p… |
| IRE | Stillström et al · Cardiovasc Intervent Radiol | 2021 | Retrospektif Klinik Çalışma | İnsan | Elektrot Geometrisi ve Yerleşimi, İrreversible Por Oluşumu ve Hücre Ölümü | 60 / 84 | NanoKnife | – | – | Purpose: Evaluate the accuracy of multiple electrode placements in IRE treatment of liver tumours using a stereotactic CT-based navigation system. Method: Analysing data from all IRE treatme… |
| IRE | Freeman et al · Cardiovasc Intervent Radiol | 2020 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 23 / 33 | NanoKnife | – | tam yanıt 87.9% (33 lezyon) | Background and aims: Irreversible electroporation (IRE) is a non-thermal ablation technique for unresectable hepatocellular carcinoma (HCC) not amenable to standard thermal ablation. The aim… |
| IRE | Cornelis et al · Cardiovasc Intervent Radiol | 2019 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 25 / 29 | NanoKnife | – | lokal kontrol 86.2% (29 lezyon) | Purpose: To evaluate the effect of peri-tumoral metallic implants (MI) on the safety and efficacy of percutaneous irreversible electroporation (IRE) of colorectal liver metastasis (CRLM). Ma… |
| IRE | Verloh et al · Radiol Oncol | 2019 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 164 / 164 | NanoKnife, Acculis microwave tissue ablation system, StarBurst, RITA, 1500X ablation system, StarBurst ablation system, RITA ablation system, 1500X ablation system | – | tam yanıt 70.1% (117 hasta) | Background To compare the frequency of adverse events of thermal microwave (MWA) and radiofrequency ablation (RFA) with non-thermal irreversible electroporation (IRE) in percutaneous ablatio… |
| IRE | Schicho et al · Cancer Manag Res | 2018 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 24 | NanoKnife | – | tam yanıt 66.7% (24 hasta) | Background: For colorectal liver metastases (CRLM) that are not amenable to surgery or thermal ablation, irreversible electroporation (IRE) is a novel local treatment modality and additional… |
| IRE | Mafeld et al · Cardiovasc Intervent Radiol | 2018 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 52 / 59 | NanoKnife | – | – | Aim: Irreversible electroporation (IRE) is a non-thermal ablative option in patients unsuitable for standard thermal ablation, due to its potential to preserve collagenous structures (vessel… |
| IRE | Niessen et al · Sci Rep | 2017 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 71 / 103 | NanoKnife | – | tam yanıt 92.2% (103 lezyon) | Aim of this retrospective analysis was to evaluate the survival times after percutaneous irreversible electroporation (IRE) in inoperable liver tumors not amenable to thermal ablation. 71 pa… |
| IRE | Beyer et al · Int J Comput Assist Radiol Surg | 2016 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 35 / 40 | NanoKnife | – | – | Objective: Comparison of conventional CT-guided manual irreversible electroporation (IRE) of malignant liver tumors and a robot-assisted approach regarding procedural accuracy, intervention … |
| IRE | Padia et al · Radiology | 2016 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 20 | NanoKnife | – | tam yanıt 18 adet (20 hasta) | Purpose: To assess the postprocedure findings of irreversible electroporation (IRE) in patients with hepatocellular carcinoma (HCC) at magnetic resonance (MR) imaging. Materials and methods:… |
| IRE | Dollinger et al · Diagn Interv Radiol | 2015 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 56 / 114 | NanoKnife | – | stabil hastalık 7.1% (85 seans) | Purpose: We aimed to describe the frequency of adverse events after computed tomography (CT) fluoroscopy-guided irreversible electroporation (IRE) of malignant hepatic tumors and their risk … |
| IRE | Dollinger et al · PLoS One | 2015 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 43 / 84 | NanoKnife | – | – | Purpose: To evaluate risk factors associated with alterations in venous structures adjacent to an ablation zone after percutaneous irreversible electroporation (IRE) of hepatic malignancies … |
| IRE | Froud et al · Tech Vasc Interv Radiol | 2015 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 124 | NanoKnife | – | – | Irreversible electroporation (IRE) is a relatively new ablation modality that uses electric currents to cause cell death. It is commonly used to treat primary and secondary liver tumors in p… |
| IRE | Dollinger et al · J Vasc Interv Radiol | 2014 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 34 / 52 | NanoKnife | – | ablasyon hacmi 57 mm (52 lezyon) | Purpose: To describe findings on contrast-enhanced computed tomography (CT) images of malignant hepatic tumors 24-72 hours after percutaneous ablation by irreversible electroporation (IRE) a… |
| IRE | Hosein et al · J Vasc Interv Radiol | 2014 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 29 / 58 | NanoKnife | – | tam yanıt 36% (28 hasta) | Purpose: To describe an initial experience with irreversible electroporation (IRE) in patients with colorectal liver metastasis (CLM). Materials and methods: A retrospective analysis of pati… |
| IRE | Narayanan et al · Journal of Vascular and Interventional Radiology | 2013 | Retrospektif Klinik Çalışma | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 60 / 74 | NanoKnife | – | progresif hastalık 75% (72 lezyon) | No. 322 Effect of irreversible electroporation (IRE) on liver function tests following treatment of primary and metastatic liver tumors: a single center retrospective analysis Posters and Ex… |
| IRE | Kingham et al · J Am Coll Surg | 2012 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 28 / 65 | NanoKnife | – | lokal kontrol 94.3% | Background: Ablation is increasingly used to treat primary and secondary liver cancer. Ablation near portal pedicles and hepatic veins is challenging. Irreversible electroporation (IRE) is a… |
| IRE | Narayanan et al · Cardiovasc Intervent Radiol | 2012 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 43 / 56 | NanoKnife, RF 3000 radiofrequency generator, LeVeen needle electrode | – | progresyonsuz sağkalım 1.96 skor (28 seans) | Purpose: To retrospectively compare the postprocedure pain of hepatocellular carcinoma treated with irreversible electroporation (IRE) with radiofrequency ablation (RFA). Methods: This Healt… |
| IRE | Zhang · Eur Radiol Exp | 2026 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 17 / 18 | Dophi N3000 Electroporation System | – | lokal kontrol 94.4% (18 lezyon) | Objective: Irreversible electroporation (IRE) is a non-thermal ablation technique suitable for tumors near critical structures, but its widespread use is limited by technical complexity and … |
| IRE | Wada et al · Cancers (Basel) | 2023 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 322 / 366 | NanoKnife | – | lokal kontrol 0% (15 hasta) | Background: Despite the diversity of thermal ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), and non-thermal ablation, such as irreversible electroporation (IR… |
| ECT | Trotovsek et al · Front Oncol | 2022 | Vaka Serisi | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 2 / 3 | Stinger electrode, electric pulse generator | bleomisin · intravenöz | tam yanıt 100% | Electrochemotherapy is an effective treatment modality for hepatocellular carcinoma (HCC). Electrochemotherapy for HCC was initially used in the setting of open surgery. Recently, with the d… |
| ECT | Spallek et al · Radiol Oncol | 2022 | Vaka Serisi | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Kas Kasılması ve Anestezi Gereksinimi | 18 / 21 | Cliniporator VITAE | bleomisin · intravenöz | nesnel yanıt 85.7% (21 lezyon) | Background: Local nonsurgical tumor ablation currently represents a further option for the treatment of patients with liver tumors or metastases. Electrochemotherapy (ECT) is a welcome addit… |
| IRE | Stillström et al · Eur J Radiol Open | 2019 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 42 / 59 | – | – | lokal nüks 3% (59 lezyon) | Introduction: Thermal ablation of liver tumours is an established technique used in selected patients with relatively small tumours that can be ablated with margin. Thermal ablation methods … |
| ECT | Tarantino et al · World J Gastroenterol | 2017 | Vaka Serisi | İnsan | Apoptoz İndüksiyonu, Nekroz ve Nekroptoz | 6 | Cliniporator VITAE | bleomisin · intravenöz | tam yanıt 6 adet (6 hasta) | Aim: To treated with electrochemotherapy (ECT) a prospective case series of patients with liver cirrhosis and Vp3-Vp4- portal vein tumor thrombus (PVTT) from hepatocellular carcinoma (HCC), … |
| ECT | Edhemovic et al · Handbook of Electroporation | 2017 | Vaka Serisi | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 8 / 14 | Cliniporator VITAE, Cliniporator | bleomisin · intravenöz | tam yanıt 85% (14 lezyon) | Electrochemotherapy (ECT) is a local treatment modality of malignant tumors. It uses electroporation which significantly increases the concentration of bleomycin or cisplatin in cells and the… |
| IRE | Sutter et al · Radiology | 2017 | Vaka Serisi | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 58 / 75 | NanoKnife | – | tam yanıt 77.3% (75 lezyon) | Purpose To assess the safety and efficacy of irreversible electroporation (IRE) in the treatment of patients with inoperable hepatocellular carcinoma (HCC) who are ineligible for thermal abl… |
| ECT | Tarantino et al · Digestive and Liver Disease | 2016 | Vaka Serisi | İnsan | – | 6 | Cliniporator VITAE | bleomisin · intravenöz | tam yanıt 100% (6 hasta) | Bu yayında özet bulunmuyor. |
| ECT | Tarantino et al · Journal of Hepatology | 2016 | Vaka Serisi | İnsan | – | 6 | Cliniporator VITAE | bleomisin · intravenöz | tam yanıt 100% (6 hasta) | Bu yayında özet bulunmuyor. |
| ECT | Tarantino et al · Digestive and Liver Disease | 2016 | Vaka Serisi | İnsan | – | 6 / 6 | Cliniporator VITAE | bleomisin · intravenöz | tam yanıt 1 adet (6 hasta) | Bu yayında özet bulunmuyor. |
| Diğer EP | Gad et al · Front Immunol | 2026 | Vaka Raporu | İnsan | Sistemik / Abskopal İmmün Yanıt, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 1 / 2 | Aliya | – | tam yanıt 5 adet (6 lezyon) | Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy, typically presenting at an advanced stage with distant metastases. We report a unique case of a 49-year-old fema… |
| IRE | Dantas Henrique et al · J Vasc Interv Radiol | 2026 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 1 / 1 | NanoKnife | – | tam yanıt 1 adet (1 hasta) | Bu yayında özet bulunmuyor. |
| IRE | Romeo et al · Radiol Case Rep | 2026 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 1 / 1 | Dophi N3000 | – | tam yanıt 1 adet (1 lezyon) | Interventional ultrasound (IUS) supported by contrast-enhanced ultrasound (CEUS) enables accurate real-time characterization and image-guided treatment of focal liver lesions. In nonsurgical… |
| ECT | Sallemi et al · Cardiovasc Intervent Radiol | 2025 | Vaka Raporu | İnsan | – | – | Cliniporator VITAE | bleomisin | – | , Hepatocellular carcinoma (HCC) with biliary invasion is an uncommon but highly challenging condition, often associated with obstructive jaundice, hepatic decompensation, and ineligibility … |
| IRE | L'Huillier et al · Diagn Interv Imaging | 2023 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 5 / 5 | NanoKnife, EPIONE | – | tam yanıt 100% (5 hasta) | , Irreversible electroporation (IRE) is a non-thermal ablative approach used for the treatment of liver cancers, including hepatocellular carcinoma (HCC) and liver metastases [1−4]. It allow… |
| IRE | Onafowokan et al · BMJ Case Rep | 2022 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 1 / 1 | NanoKnife | – | genel sağkalım 20 ay (1 hasta) | Irreversible electroporation (IRE) is a non-thermal ablative technique for unresectable liver malignancies deemed unsuitable for traditional thermal ablation due to proximity to biliary and/… |
| ECT | Luerken et al · Cardiovasc Intervent Radiol | 2021 | Vaka Raporu | İnsan | – | – / 2 | Cliniporator VITAE, Cliniporator | bleomisin · intravenöz | tam yanıt 100% (1 lezyon) | Electrochemotherapy (ECT) is a novel non-thermal ablative technique that combines chemotherapy and the application of electric pulses for reversible cell membrane electroporation. This metho… |
| ECT | Stefano et al · Front Surg | 2021 | Vaka Raporu | İnsan | Nekroz ve Nekroptoz, Bleomisin Hücre İçi Birikiminin Artması | 1 / 4 | Cliniporator | bleomisin · intravenöz | tam yanıt 1 adet (1 lezyon) | Introduction: Cholangiocarcinoma (CCA) is the second most common primary tumor of the liver, and the recurrence after hepatic resection (HR), the only curative therapy, is linked with a wors… |
| ECT | Djokic et al · Radiol Oncol | 2020 | Vaka Raporu | İnsan | Elektrot Geometrisi ve Yerleşimi | 1 / 1 | – | bleomisin · intravenöz | tam yanıt 1 oran (1 lezyon) | Background Electrochemotherapy is an effective treatment of colorectal liver metastases and hepatocellular carcinoma (HCC) during open surgery. The minimally invasive percutaneous approach o… |
| ECT | Pacella et al · Interv Med Clin Imaging | 2019 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Ekstraselüler Matriks ve Doku İskeletinin Korunması | 1 / 1 | – | bleomisin · intravenöz | tümör hacmi değişimi 0 cm³ (1 hasta) | Introduction: Electrochemotherapy (ECT) is a locally enhanced chemotherapy that combines the administration of chemotherapeutic drugs with welldosed electric pulses for cell membrane Electro… |
| IRE | Chai et al · Ultrasound Q | 2017 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 1 | NanoKnife | – | tam yanıt 1 adet (1 hasta) | *Department of Ultrasonography and †State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou… |
| IRE | Herwald et al · J Vasc Interv Radiol | 2016 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 1 / 1 | NanoKnife | – | tam yanıt 1 adet (1 hasta) | Carcinoma Adjacent to the Gallbladder From: Sanna E. Herwald, BA Jonathan H. Chen, MD, PhD Ronald S. Arellano, MD, FSIR Tufts University School of Medicine (S.E.H.) 145 Harrison Avenue Bosto… |
| IRE | Cheng et al · J Vasc Interv Radiol | 2015 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 6 / 6 | NanoKnife | – | tam yanıt 100% (6 hasta) | Purpose: To describe full explant pathology and radiographic correlation in patients with hepatocellular carcinoma (HCC) treated with irreversible electroporation (IRE) who subsequently unde… |
| IRE | Sugimoto et al · Springerplus | 2015 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 1 / 3 | NanoKnife | – | – | Introduction: Irreversible electroporation (IRE) is a promising technique for the focal treatment of soft tissue tumors. Even though the local application of an excessive electric field is a… |
| IRE | Scheffer et al · Cardiovasc Intervent Radiol | 2014 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 1 / 1 | NanoKnife | – | tümör hacmi değişimi 22% (1 hasta) | Irreversible electroporation (IRE) is a novel image-guided ablation technique that is rapidly gaining popularity in the treatment of malignant liver tumors located near large vessels or bile… |
| IRE | Niessen et al · Korean J Radiol | 2013 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 1 / 1 | NanoKnife | – | tam yanıt 100% (1 hasta) | We report in a 65-year-old man hepatocellular carcinoma adjacent to a transjugular intrahepatic portosystemic shunt stent-graft which was successfully treated with irreversible electroporati… |
| IRE | Niessen et al · Rofo | 2012 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 1 / 1 | NanoKnife | – | tam yanıt 1 adet (1 hasta) | Einführung In den letzten Jahren haben minimalinvasive Behandlungstechniken deutlich an Bedeutung gewonnen, insbesondere wenn chirurgische Interventionen nicht als Behandlungsalternative inf… |
| IRE | Mannelli et al · Liver Int | 2012 | Vaka Raporu | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 1 / 1 | – | – | – | Bu yayında özet bulunmuyor. |
| IRE | Iqbal et al · Cureus | 2026 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | tam yanıt 0.98 oran | The aim of this study was to systematically pool all direct comparative evidence from two-arm studies comparing irreversible electroporation (IRE) and radiofrequency ablation (RFA) for hepat… |
| IRE | Cribbs · PLoS One | 2025 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 195 | – | – | nesnel yanıt 95% (195 hasta) | Background: Locoregional treatments for early-stage unresectable hepatocellular carcinoma (HCC) are widely used, with irreversible electroporation (IRE) and transarterial chemoembolization (… |
| ECT | Barbieri et al · Curr Oncol | 2024 | Sistematik Derleme / Meta-Analiz | İnsan | – | – / 128 | – | bleomisin · intravenöz | tam yanıt 0% (128 lezyon) | Background: The global incidence of secondary liver cancer is rising due to multiple risk factors, presenting significant challenges in public health. Similarly, colorectal cancer (CRC) rema… |
| IRE | Xing · Open Life Sci | 2024 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 10 / 17 | – | – | – | Both irreversible electroporation (IRE) and radiofrequency ablation (RFA) are viable ablation methods for localized treatment of liver tumors. We conducted a meta-analysis to access the effi… |
| ECT | Granata et al · Diagnostics (Basel) | 2023 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | – / 16 | – | bleomisin · intravenöz | lokal kontrol 81% (211 lezyon) | The aim of the study was to analyse papers describing the use of Electrochemotherapy (ECT) in local treatment of primary and secondary liver tumours located at different sites and with diffe… |
| IRE | Spiers · Cancers (Basel) | 2023 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 180 / 315 | – | – | – | Background: Irreversible electroporation (IRE) is a non-thermal form of ablation based on the delivery of pulsed electrical fields. It has been used to treat liver lesions, particularly thos… |
| IRE | Nieuwenhuizen · Curr Oncol Rep | 2022 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 9 / 9 | – | – | lokal kontrol 44.4% | Purpose of review: Based on good local control rates and an excellent safety profile, guidelines consider thermal ablation the gold standard to eliminate small unresectable colorectal liver … |
| IRE | Yu et al · Eur J Surg Oncol | 2022 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 807 / 1115 | – | – | tam yanıt 86% | Objective: To evaluate the efficacy and safety of IRE in the treatment of hepatic malignant tumors, especially the damage to the gastrointestinal tract, bile ducts, and vital vessels. Method… |
| IRE | Gupta et al · Eur Radiol | 2021 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 776 | – | – | genel sağkalım 93.28% (88 hasta) | Objective: The data regarding overall survival (OS) and progression-free survival (PFS) following irreversible electroporation (IRE) is scarce. We performed a systematic review of the safety… |
| IRE | Tian et al · Oncotarget | 2016 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 300 | – | – | tümör hacmi değişimi -1 skor | Background: Irreversible electroporation (IRE) ablation is a new technique that is used to eliminate malignant tumors through nonthermal approaches. Objective: The purpose of this review was… |
| Belirlenmedi | Persico et al · JDReAM | 2026 | Kılavuz / Uzlaşı | İnsan | – | – | – | – | – | The new therapeutic options now available for patients with hepatocellular carcinoma (HCC) have made their assessment more complex, especially due to the different stages of liver cirrhosis … |
| IRE | Xu et al · Hepatobiliary Pancreat Dis Int | 2022 | Kılavuz / Uzlaşı | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Liver cancer remains a global health challenge, and its incidence is increasing worldwide. It is estimated that by 2025, more than one million individuals will be affected by liver cancer an… |
| Diğer EP | Seda · ESMO Gastrointest Oncol | 2026 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Liver cancer, especially hepatocellular carcinoma (HCC), which accounts for ∼75%-85% of primary liver cancers, remains a major global health challenge. Because of its high incidence, late di… |
| Diğer EP | Liang et al · Zhonghua Gan Zang Bing Za Zhi | 2026 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Thermal ablation has become an important treatment option for early-stage hepatocellular carcinoma with the development of interventional ultrasound technology. However, in the treatment of … |
| ECT | Posa et al · Livers | 2025 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu | – | – | – | – | The global burden of liver metastases from different primary lesions is increasing, resulting in significant challenges for public health systems. Accordingly, colorectal cancer (CRC) remain… |
| IRE | Franke · Pol J Radiol | 2025 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Colorectal cancer is a prevalent malignancy, with colorectal liver metastases (CLM) being a common and challenging clinical issue. Traditionally, surgical resection was the only curative tre… |
| Diğer EP | Abu Zahra et al · Cancers (Basel) | 2025 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with curative surgical interventions feasible for a minority of patients. This review highlights rece… |
| Diğer EP | Gao · Int J Nanomedicine | 2025 | Derleme | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal primary liver malignancies worldwide. Despite significant advances in surgical resection and local ablation therap… |
| IRE | Giorgio et al · World J Gastroenterol | 2025 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Ultrasound-guided percutaneous thermal ablation has gained popularity as treatment for malignant hepatic tumors. It was first introduced as ablation therapy for hepatocellular carcinoma and … |
| Diğer EP | Li · J Hepatocell Carcinoma | 2025 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Early-stage hepatocellular carcinoma (HCC) represents a critical window for curative treatment. However, treatment selection is complicated by significant heterogeneity in tumor biology, liv… |
| Diğer EP | Xenos · Biomedicines | 2025 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Cancer is a leading cause of cancer-related death. Liver metastases develop in over one-third of patients and are associated with worse prognosis. The evolution in the field of interventiona… |
| Diğer EP | Chlorogiannis et al · Medicina (Kaunas) | 2024 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Colorectal cancer is a major cause of cancer-related mortality, with liver metastases occurring in over a third of patients, and is correlated with poor prognosis. Despite surgical resection… |
| IRE | Narayanan et al · Medicina (Kaunas) | 2024 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | lokal nüks 94.6% (44 hasta) | Liver cancer remains a leading cause of cancer-related deaths worldwide despite numerous advances in treatment. While surgical resection remains the gold standard for curative treatment, it … |
| Diğer EP | Zhao · J Cancer | 2024 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | With the development of guidance technology and ablation equipment, ablative procedures have emerged as important loco-regional alternatives to surgical resection for recurrent hepatocellula… |
| Diğer EP | Wang · World J Hepatol | 2023 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | genel sağkalım 81.3% | Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is the fifth leading cause of cancer death worldwide and the third leading cause of all diseases worldwide. Liver t… |
| Diğer EP | Song · Front Oncol | 2023 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Objective: Ablation is a common treatment for hepatocellular carcinoma (HCC). This study aimed to assess research trends in the ablation treatment of HCC using bibliometric analysis. Methods… |
| Diğer EP | Koza et al · Biomedicines | 2023 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 25 / 48 | – | – | – | The management of hepatocellular carcinoma (HCC) remains complex and will continue to rely on the multidisciplinary input of hepatologists, surgeons, radiologists, oncologists and radiothera… |
| Diğer EP | Qu et al · Med Sci Monit | 2023 | Derleme | Literatür Analizi | Kas Kasılması ve Anestezi Gereksinimi, Reversible Membran Permeabilizasyonu | – | – | – | – | BACKGROUND Ablation has been developed as a radical surgical procedure for liver tumors. Local anesthesia in combination with general anesthesia or intravenous sedation is needed in ablative… |
| Diğer EP | Papalexis et al · Curr Oncol | 2022 | Derleme | İnsan | – | – | – | bleomisin · intravenöz | – | Metastases are the main type of malignancy involving bone, which is the third most frequent site of metastatic carcinoma, after lung and liver. Skeletal-related events such as intractable pa… |
| IRE | Belfiore · Front Oncol | 2022 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | bleomisin | – | Tumour ablation is an established therapy for local treatment of liver metastases and hepatocellular carcinoma. Most commonly two different kind of thermic ablation, radiofrequency ablation … |
| IRE | Cano · An Sist Sanit Navar | 2022 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Currently, among the possible treatments for hepatocellular carcinoma there is group of minimally invasive ablation techniques with wide clinical acceptance due to their greater efficacy and… |
| Diğer EP | De Re et al · Front Oncol | 2022 | Derleme | Literatür Analizi | İmmünojenik Hücre Ölümü (ICD), Reversible Membran Permeabilizasyonu | – | – | bleomisin | – | Ablative and locoregional treatment options, such as radiofrequency, ethanol injection, microwave, and cryoablation, as well as irreversible electroporation, are effective therapies for earl… |
| IRE | Koethe et al · Int J Hyperthermia | 2022 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) ablation is gaining popularity over the last decade as a nonthermal alternative to thermal ablation technologies such as radiofrequency ablation (RFA) and … |
| IRE | Eresen et al · Ann Transl Med | 2021 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Hepatocellular carcinoma (HCC) is among the most lethal cancer types despite great advancement in overall survival of the patients over the last decades. Surgical resection or partial hepate… |
| IRE | Liu et al · World J Gastroenterol | 2020 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | The number of liver cancer patients is likely to continue to increase in the coming decades due to the aging of the population and changing risk factors. Traditional treatments cannot meet t… |
| IRE | Cohen et al · Expert Rev Med Devices | 2018 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 30 / 30 | – | – | – | Introduction: Irreversible electroporation (IRE) has developed as a novel percutaneous ablative technique over the past decade and its utility in the treatment of primary and metastatic live… |
| Diğer EP | Nault et al · J Hepatol | 2018 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Percutaneous treatment of hepatocellular carcinoma (HCC) encompasses a vast range of techniques, including monopolar radiofrequency ablation (RFA), multibipolar RFA, microwave ablation, cryo… |
| ECT | Trotovšek et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | bleomisin · intravenöz | – | Incidence of primary liver cancer (PLC) is rising across the world. Hepatocellular carcinoma (HCC) is the most common (90%) and together with intrahepatic cholangiocarcinoma represents more … |
| IRE | Zimmerman et al · J Hepatocell Carcinoma | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) is a novel form of tissue ablation that uses high-current electrical pulses to induce pore formation of the cell lipid bilayer, leading to cell death. The … |
| Diğer EP | Vogl · Viszeralmedizin | 2015 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Background: The purpose of this review is to demonstrate the clinical indications, technical developments, and outcome of liver-directed therapies in interventional oncology of non-colorecta… |
| IRE | Lencioni et al · Tech Vasc Interv Radiol | 2015 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 29 / 29 | – | – | tam yanıt 79% (29 lezyon) | Irreversible electroporation (IRE) is a new nonthermal ablation modality that can be used to treat primary and metastatic lesions in the liver. This article describes the way IRE works, revi… |
| IRE | Scheffer et al · Tech Vasc Interv Radiol | 2015 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Image-guided tumor ablation techniques have significantly broadened the treatment possibilities for primary and secondary hepatic malignancies. A new ablation technique, irreversible electro… |
| IRE | Martin · Curr Colorectal Cancer Rep | 2013 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 45 | – | – | lokal nüks 2.6% | Irreversible electroporation (IRE) has shown promise for ablation of lesions in proximity to vital structures in the preclinical and now clinical setting. Studies of patients undergoing IRE … |
| IRE | Narayanan et al · Semin Intervent Radiol | 2013 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 33 | – | – | progresyonsuz sağkalım 11.6 ay (33 hasta) | Hepatocellular carcinoma (HCC) is a worldwide problem of epidemic proportions, best treated in a multidisciplinary setting. Major advances have been made in all specialties that manage patie… |
| IRE | Lee et al · J Vasc Interv Radiol | 2012 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Purpose: To show the effectiveness and safety of irreversible electroporation (IRE) in treating large tumor models. Materials and methods: VX2 liver tumor implantation was performed in 35 Ne… |
| IRE | López-Alonso et al · Sci Rep | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Bleomisin Hücre İçi Birikiminin Artması | – | custom versatile high-voltage pulse generator | bleomisin · intravenöz | tümör hacmi değişimi 95.5% | Electroporation-based therapies are established non-thermal ablation strategies for targeted tissue destruction. Here, a custom high-voltage pulse generator and a parallel-plate electrode sy… |
| IRE | Huo et al · JHEP Rep | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | 9 | – | – | tümör hacmi değişimi 84.3% | Background & aims: Local ablation triggers anti-tumor response and is regarded as an encouraging treatment combined with immunotherapy for hepatocellular carcinoma (HCC). Irreversible electr… |
| IRE | Park · Signal Transduct Target Ther | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Chimeric antigen receptor natural killer (CAR-NK) cell therapy has emerged as a promising immunotherapeutic modality with potent cytotoxicity and a favorable safety profile. However, its the… |
| IRE | Zhou et al · Radiol Oncol | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – / 24 | – | – | – | Background: This study aimed to explore the ultrasound and contrast-enhanced ultrasound (CEUS) imaging characteristics and dimensions of ablation lesions after irreversible electroporation o… |
| ECT | Spiliotis et al · Cancers (Basel) | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | – | SENNEX | bleomisin · intravenöz | – | Background/objectives: Electrochemotherapy (ECT) has been shown to be effective in treating colorectal liver metastases when combined with bleomycin (BLM). Based on this promising finding, w… |
| IRE | Xing et al · World J Gastrointest Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | – | – | – | – | Background: Irreversible electroporation (IRE) represents an innovative localized technique for tumor ablation, possessing the capacity to activate the immune response of the host. However, … |
| IRE | Wang · Sci Rep | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, İrreversible Por Oluşumu ve Hücre Ölümü | – | BPG300 | – | – | The safety and efficacy of irreversible electroporation (IRE) in tumor therapy has been validated over many years by clinical application. An in-depth study, however, is required to assess t… |
| IRE | Yu et al · World J Gastroenterol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BPG 300 | – | – | Background: Duodenal mucosal ablation (DMA) using irreversible electroporation (IRE) with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid depositio… |
| ECT | Spiliotis et al · Sci Rep | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | – | SENNEX | bleomisin · intravenöz | – | Electrochemotherapy (ECT) combines the reversible electroporation (rEP) with intravenous (i.v.) or intratumoral (i.t.) administration of chemotherapeutic drugs. We conducted this study to co… |
| ECT | Spiliotis et al · – | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | – / 24 | SENNEX | bleomisin · intravenöz | tümör hacmi değişimi 39.7 cm³ (8 hayvan) | Electrochemotherapy (ECT) combines the reversible electroporation (rEP) with intravenous (i.v.) or intratumoral (i.t.) administration of chemotherapeutic drugs. We conducted this study to co… |
| IRE | Li et al · Cancer Med | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | compound steep-pulse therapeutic device | – | – | Background: Malignant liver tumors seriously endanger human health. Among different therapeutic approaches, high-frequency irreversible electroporation (H-FIRE) is a recently emerging tumor … |
| Diğer EP | Cvetkoska et al · J Cardiovasc Dev Dis | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | 16 | – | – | – | Electroporation is used in medicine for drug and gene delivery, and as a nonthermal ablation method in tumor treatment and cardiac ablation. Electroporation involves delivering high-voltage … |
| ECT | Spiliotis et al · Cancers (Basel) | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | – / 32 | SENNEX | bleomisin · intravenöz | – | Background: The available ablative procedures for the treatment of hepatic cancer have contraindications due to the heat-sink effect and the risk of thermal injuries. Electrochemotherapy (EC… |
| IRE | Jeon et al · Technol Cancer Res Treat | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) is a non-thermal and minimal invasive modality to ablate pathologic lesions such as hepatic tumors. Histological analysis of the initial lesions after IRE … |
| IRE | Kim · Technol Cancer Res Treat | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Darbe Parametrelerinin Optimizasyonu | – | EPO1 | – | – | Unlike necrosis by thermal ablation, irreversible electroporation (IRE) is known to induce apoptosis by disrupting plasma membrane integrity with electric pulses while preserving the structu… |
| IRE | Lindelauf et al · Sci Prog | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830, NanoKnife | – | – | Electroporation (EP) is widely used in medicine, such as cancer treatment, in form of electrochemotherapy or irreversible electroporation (IRE). For EP device testing, living cells or tissue… |
| IRE | Sarreshtehdari et al · Sci Rep | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Due to electrical features of the tissue, such as impedance, which have a significant impact on irreversible electroporation (IRE) function, the administration of glucose solution 5% (GS5%) … |
| ECT | Cindric et al · Sci Rep | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, İrreversible Por Oluşumu ve Hücre Ölümü | – | Cliniporator | bleomisin | – | Electrochemotherapy (ECT) and irreversible electroporation (IRE) are being investigated for treatment of hepatic tumours. The liver is a highly heterogeneous organ, permeated with a network … |
| IRE | Eresen et al · Acad Radiol | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Rationale and objectives: Irreversible electroporation (IRE) is a promising non-thermal ablation technique for the treatment of patients with hepatocellular carcinoma. Early differentiation … |
| Diğer EP | Weinert · Ann Biomed Eng | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Biological electroporation is a process of opening pores in the cell membrane when exposed to intense electric fields. This work provides results for validation of a dynamic model of electro… |
| IRE | Dai et al · Cancer Lett | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Ablative treatment evokes antitumor immunity, but knowledge on the emerging irreversible electroporation (IRE)-induced immunity in hepatocellular carcinoma (HCC) is limited. To investigate t… |
| IRE | Lasarte-Cia et al · Biomed Res Int | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Background/aim Irreversible electroporation (IRE) showed promising results for small-size tumors and very early cancers. However, further development is needed to evolve this procedure into … |
| IRE | Li et al · Chin Med J (Engl) | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | YTL-GM01, custom-built H-FIRE waveform generator | – | – | Background: High-frequency irreversible electroporation (H-FIRE) is a novel, next-generation nanoknife technology with the advantage of relieving irreversible electroporation (IRE)-induced m… |
| IRE | Lopez-Ichikawa · Sci Rep | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) is a non-thermal tissue ablative technology that has emerging applications in surgical oncology and regenerative surgery. To advance its therapeutic useful… |
| IRE | Sorokin et al · J Endourol | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Objective: To evaluate the safety of irreversible electroporation (IRE) for renal ablation adjacent to the ureter or bowel. Materials and Methods: Six adult pigs each underwent bilateral IRE… |
| IRE | Kaufman et al · J Vasc Interv Radiol | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | custom pulse generator based on an H-Bridge topology | – | – | Purpose: To investigate if high-frequency irreversible electroporation (H-FIRE) treatments can be delivered at higher voltages and with greater energy delivery rates than currently implement… |
| IRE | Partridge et al · J Vasc Interv Radiol | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – / 3 | EPULSUS-FBM1-5 | – | – | Purpose: To determine the safety and feasibility of percutaneous high-frequency irreversible electroporation (HFIRE) for primary liver cancer and evaluate the HFIRE-induced local immune resp… |
| IRE | Shangguan et al · Clin Exp Gastroenterol | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Purpose: Irreversible electroporation (IRE) is a promising new ablation method for hepatocellular carcinoma (HCC) treatment with few side-effects; however, tissue perfusion and differentiati… |
| ECT | Brloznik et al · Radiol Oncol | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Hemostaz ve Kanama Kontrolü | – | Cliniporator | bleomisin · intravenöz | – | Background Radiologic findings after electrochemotherapy of large hepatic blood vessels and healthy hepatic parenchyma have not yet been described. Materials and methods We performed a prosp… |
| ECT | Zmuc et al · European Journal of Surgical Oncology | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has significantly improved overall survival of patients with peritonitis carcinomatosa (PC) of colorectal ori… |
| IRE | Figini et al · Magn Reson Med | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 17 | BTX ECM830 | – | tümör hacmi değişimi -70% (14 lezyon) | Purpose: Irreversible electroporation (IRE) is a nonthermal tissue ablation technique that represents a promising treatment option for unresectable liver tumors, but the effectively treated … |
| IRE | Hu et al · J Vasc Interv Radiol | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830, BTX Electroporator | – | – | Purpose: To evaluate the feasibility of diffusion-weighted imaging (DWI) in magnetic resonance imaging for quantitative measurement of responses following irreversible electroporation (IRE) … |
| IRE | Lyu et al · HPB (Oxford) | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | tümör hacmi değişimi 1593% (27 hayvan) | Background: The safety and efficacy of irreversible electroporation (IRE) in treating hepatic, biliary, and pancreatic malignancies are active areas of clinical investigation. In addition, r… |
| IRE | Vivas et al · J Vasc Interv Radiol | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | Bio-Rad Gene Pulser II Electroporation System | – | – | Purpose: To evaluate the therapeutic efficacy of irreversible electroporation (IRE) combined with the intratumoral injection of the immunogenic adjuvant poly-ICLC (polyinosinic-polycytidylic… |
| IRE | Vogel et al · Technol Cancer Res Treat | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | NanoKnife | – | – | Irreversible electroporation causes cell death through low frequency, high voltage electrical pulses and is increasingly used to treat non-resectable cancers. A recent systematic review reve… |
| IRE | Castellví et al · Phys Med Biol | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation-based treatments typically consist of the application of high-voltage dc pulses. As an undesired side effect, these dc pulses cause electrical stimulation of excitable tissue… |
| IRE | Sano et al · Comput Biol Med | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | ablasyon hacmi 2.2 cm³ | High-frequency irreversible electroporation (H-FIRE) is an emerging ablation modality, delivering rapid bursts of bipolar microsecond-duration electrical pulses to non-thermally ablate tissu… |
| IRE | Zhang et al · Biochem Biophys Res Commun | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Nekroz ve Nekroptoz | – | BTX ECM830 | – | – | Non-thermal irreversible electroporation (NTIRE) is a biophysical phenomenon in which certain electric fields delivered across the cell membrane in tissue, cause cell death, without affectin… |
| IRE | Wang et al · Radiology | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Apoptoz İndüksiyonu | – / 14 | BTX ECM830 | – | tümör hacmi değişimi -1.91% (14 hayvan) | Purpose To test the hypothesis that biomarkers of fluorine 18 ( 18 F) fluorodeoxyglucose (FDG) positron emission tomography (PET) can be used for the early detection of therapeutic response … |
| IRE | Cornelis et al · Cardiovasc Intervent Radiol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Purpose: To compare ablation boundary sharpness after percutaneous radiofrequency ablation (RFA), cryoablation (CA), microwave ablation (MWA) and irreversible electroporation (IRE) ablation … |
| IRE | Ivey et al · Biophys J | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | INSPIRE 2.0, BTX ECM830 | – | – | Pulsed electric fields applied to cells have been used as an invaluable research tool to enhance delivery of genes or other intracellular cargo, as well as for tumor treatment via electroche… |
| IRE | Pañella et al · Radiol Oncol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Background: Spread hepatic tumours are not suitable for treatment either by surgery or conventional ablation methods. The aim of this study was to evaluate feasibility and safety of selectiv… |
| IRE | Sánchez-Velázquez et al · Sci Rep | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Nekroz ve Nekroptoz | – | custom made generator | – | genel sağkalım 74.3 gün (13 hayvan) | Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time su… |
| IRE | Yao et al · IEEE Trans Biomed Eng | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Kas Kasılması ve Anestezi Gereksinimi, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Objective: To minimize the effect of muscle contractions during irreversible electroporation (IRE), this paper attempts to research the ablation effect and muscle contractions by applying hi… |
| IRE | Bhutiani et al · Surgery | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Objective: Currently, the prediction of the dimensions of irreversible electroporation (IRE) ablation is modeled using algorithms derived from mathematical and ex vivo models. These algorith… |
| IRE | Bulvik et al · Radiology | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife, BTX Tweezerode 522 | – | – | Purpose To compare both periablational and systemic effects of two mechanistically different types of ablation: thermal radiofrequency (RF) ablation and electroporative ablation with irrever… |
| IRE | Golberg et al · PeerJ | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX 830 pulse generator, BTX Tweezertrodes | – | – | During the past decade, irreversible electroporation (IRE) ablation has emerged as a promising tool for the treatment of multiple diseases including hepatic cancer. However, the mechanisms b… |
| IRE | Sano et al · J Vasc Interv Radiol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | custom pulse generation system | – | – | Purpose: To mathematically model and test ex vivo a modified technique of irreversible electroporation (IRE) to produce large spherical ablations by using a single probe. Materials and metho… |
| IRE | Siddiqui et al · HPB (Oxford) | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 15 | – | – | – | Introduction: Irreversible electroporation (IRE) offers an alternative to thermal tissue ablation in situ. High-frequency IRE (H-FIRE), employing ultra-short bipolar electrical pulses, may o… |
| IRE | Sánchez-Velázquez et al · Sci Rep | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | genel sağkalım 52.8% (87 hayvan) | Irreversible electroporation is a fast-growing liver ablation technique. Although safety has been well documented in small ablations, our aim is to assess its safety and feasibility when a l… |
| IRE | Vollherbst et al · J Vasc Interv Radiol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 18 | NanoKnife | – | – | Purpose: To evaluate the effects of combined use of transarterial chemoembolization and irreversible electroporation (IRE) for focal tissue ablation in an acute porcine liver model. Material… |
| IRE | Srimathveeravalli et al · J Vasc Interv Radiol | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 10 | NanoKnife | – | ablasyon hacmi 10 adet (10 lezyon) | Purpose: To evaluate the feasibility of focal intraluminal irreversible electroporation (IRE) in the ureter with a novel electrode catheter and to study the treatment effects in response to … |
| IRE | Sugimoto et al · J Vasc Interv Radiol | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 12 | NanoKnife, CelonPOWER System | – | – | Purpose: To assess various ultrasound (US) findings, including B-mode, shear-wave elastography (SWE), and contrast-enhanced US, in accurately assessing ablation margins after irreversible el… |
| Diğer EP | Forde et al · Mol Ther Methods Clin Dev | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | EndoVe | plazmid DNA · intratümöral | – | Nonviral plasmid DNA gene therapy represents a promising approach for the treatment of many diseases including cancer. Intracellular delivery of DNA can be achieved with the application of e… |
| Diğer EP | Kulbacka et al · Bioelectrochemistry | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | BTX ECM830 | diğer · diğer yol | – | Electroporation (EP) can effectively support the penetration of macromolecules from the extracellular space into cells. Electropores induced by the influence of electromagnetic field generat… |
| IRE | Appelbaum et al · Radiology | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | – | NanoKnife | – | – | Purpose: To prospectively determine optimal parameters with which to achieve defined large target zones of coagulation by using irreversible electroporation (IRE) with four-electrode arrays … |
| IRE | Jiang et al · Ann Biomed Eng | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | The use of irreversible electroporation (IRE) for cancer treatment has increased during the past decade due to many advantages over other focal therapies. However, despite early success in p… |
| IRE | Sommer et al · Cardiovasc Intervent Radiol | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 20 | NanoKnife | – | – | Purpose: To evaluate the effect of previous transarterial iodized oil tissue marking (ITM) on technical parameters, three-dimensional (3D) computed tomographic (CT) rendering of the electrop… |
| IRE | Zhang et al · Radiology | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | ablasyon hacmi 2 skor (6 hayvan) | Purpose: To compare changes on ultrasonographic (US), computed tomographic (CT), and magnetic resonance (MR) images after irreversible electroporation (IRE) ablation of liver and tumor tissu… |
| Diğer EP | Chen et al · Eur J Cancer | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Apoptoz İndüksiyonu | – | – | – | tam yanıt 80% (36 hayvan) | Strategies for treating liver cancer using radiation, chemotherapy combinations and tyrosine kinase inhibitors targeting specific mutations have provided longer survival times, yet multiple … |
| Diğer EP | Park et al · Biochem Biophys Res Commun | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Cellectra | plazmid DNA · intratümöral | tümör hacmi değişimi 0.6 oran (5 hayvan) | The Sleeping Beauty (SB) transposon system has been receiving much attention as a gene transfer method of choice since it allows permanent gene expression after insertion into the host chrom… |
| IRE | Abdelsalam et al · Journal of Vascular and Interventional Radiology | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 22 | NanoKnife | – | ablasyon hacmi 17.2 cm³ (22 lezyon) | No. 88 Irreversible electroporation (IRE) in cirrhotic liver: preliminary experience in a large animal model MONDAY: Scientific Sessions M.E. Abdelsalam1, J.A. Chetta3, S. Harmoush1, J. Enso… |
| IRE | Arena et al · J Biomech Eng | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) is a new technology for ablating aberrant tissue that utilizes pulsed electric fields (PEFs) to kill cells by destabilizing their plasma membrane. When tre… |
| IRE | Au et al · Surgery | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Background: Irreversible electroporation (IRE) is a novel ablation technique that induces permanent membrane permeability and cell death. We are interested in ultrasound B-mode and elastogra… |
| Diğer EP | Guo et al · Invest Radiol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | sisplatin · intraarteryel | – | Rationale and objectives: Electropermeabilization involves the application of electrical pulses to increase cell membrane permeability. The purpose of our study was to demonstrate the potent… |
| IRE | Appelbaum et al · Radiology | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 58 | NanoKnife, monopolar 18-gauge electrodes | – | – | Purpose: To characterize ultrasonographic (US) findings after irreversible electroporation (IRE) to determine the utility of these findings in the accurate assessment of ablation margins. Ma… |
| IRE | Ben-David et al · AJR Am J Roentgenol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | NanoKnife, AngioDynamics electrodes | – | – | Objective: The purpose of this study was to prospectively characterize and optimize irreversible electroporation ablation to determine the best parameters to achieve the largest target zones… |
| IRE | Lee et al · J Vasc Interv Radiol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Purpose: To demonstrate, evaluate, and verify the existence of irreversible electroporation (IRE)-ablation induced nanopores on the plasma membrane of hepatocytes. Materials and methods: On … |
| IRE | Schmidt et al · HPB (Oxford) | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Nekroz ve Nekroptoz | – | – | – | – | Background: Irreversible electroporation (IRE) is a largely non-thermal method for the ablation of solid tumours. The ability of ultrasound (US) to measure the size of the IRE ablation zone … |
| IRE | Charpentier et al · HPB (Oxford) | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Background: Irreversible electroporation (IRE) is a novel, non-thermal form of ablation. We studied the safety and efficacy of IRE for the ablation of liver tissue around the liver hilum. We… |
| IRE | Deodhar et al · Cardiovasc Intervent Radiol | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 25 | NanoKnife | – | tam yanıt 100% (25 lezyon) | Objective: Irreversible electroporation (IRE) uses direct electrical pulses to create permanent "pores" in cell membranes to cause cell death. In contrast to conventional modalities, IRE has… |
| IRE | Guo et al · Radiology | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 20 | BTX ECM830 | – | – | Purpose: To evaluate the use of contrast material-enhanced magnetic resonance (MR) imaging with conventional T1-weighted gradient-recalled echo (GRE) and inversion-recovery (IR)-prepared GRE… |
| IRE | Wendler et al · Cardiovasc Intervent Radiol | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – / 9 | – | – | – | Purpose: The nonthermal irreversible electroporation (NTIRE) is a novel nonthermal tissue ablation technique by local application of high-voltage current within microseconds leading to a del… |
| IRE | Choi et al · Tissue Eng Part C Methods | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | microfabricated electroporator, real-scale clinical electroporator, microfabricated electroporator (MFE) | – | – | A microfabricated electroporator (MFE) for the irreversible electroporation (IRE) of tissues has been developed by miniaturizing a clinical electroporator with a two-needle array while keepi… |
| IRE | Guo et al · Cancer Res | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) is an innovative local-regional therapy that involves delivery of intense electrical pulses to tissue to induce nanoscale cell membrane defects for tissue … |
| IRE | Lee et al · Radiology | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Apoptoz İndüksiyonu | – / 55 | AngioDynamics IRE generator | – | – | Purpose: To evaluate the effectiveness of irreversible electroporation (IRE) in hepatic tissue ablation and the radiologic-pathologic correlation of IRE-induced cell death. Materials and met… |
| IRE | Tracy et al · BJU Int | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 24 | NanoKnife, Angiodynamics pulse generator | – | – | Objective: • To evaluate the effects of irreversible electroporation (IRE) on renal parenchyma and the renal collecting system in a porcine model. Materials and methods: • Eight female Yorks… |
| IRE | Zhang et al · Radiology | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Purpose: To test the hypothesis that magnetic resonance (MR) imaging measurements can be used to immediately detect treated tissue regions after irreversible electroporation (IRE) ablation p… |
| Gen ET | André et al · Hum Gene Ther | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator, P-15 GHT1287 electropulsator | plazmid DNA · intratümöral | – | Gene electrotransfer is gaining momentum as an efficient methodology for nonviral gene transfer. In skeletal muscle, data suggest that electric pulses play two roles: structurally permeabili… |
| Diğer EP | Takei et al · Mol Cancer Ther | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | CUY21, Square Electro Porator CUY21 | plazmid DNA · intratümöral | tümör hacmi değişimi 90% (6 hayvan) | Screening for a molecular target for cancer therapy requires multiple steps, of which an important one is evaluation of the knockdown effect of the target molecule on pregrown xenograft tumo… |
| Diğer EP | Ivorra et al · Bioelectrochemistry | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Electroporation is used for in vivo gene therapy, drug therapy and minimally invasive tissue ablation. Applying electrical pulses across cells can have a variety of outcomes; from no effect … |
| ECT | SHAO et al · Chinese Medical Journal | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Nekroz ve Nekroptoz | – | BK-92A quality EChT device | – | genel sağkalım 28 gün (30 hayvan) | The most common interventional therapies for liver cancer at present include transcatheter hepatic arterial chemoembolization (TACE),1 percutaneous ethanol injection2 and radiofrequency abla… |
| IRE | Edd et al · IEEE Trans Biomed Eng | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | This paper reports results of in vivo experiments that confirm the feasibility of a new minimally invasive method for tissue ablation, irreversible electroporation (IRE). Electroporation is … |
| ECT | Jaroszeski et al · Eur J Cancer | 2001 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | – | T820, mechanical switch | bleomisin · intratümöral | – | Preliminary studies that used electric pulses in vivo to facilitate entry of chemotherapeutic agents into tumour cells resulted in a 69% complete response rate for hepatocellular carcinoma i… |
| ECT | Jaroszeski et al · Eur J Cancer | 2001 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | BTX T820, Genetronics circular array of six needle electrodes | bleomisin · intratümöral | tam yanıt 26.67% (15 hayvan) | The effectiveness of antineoplastic agents has been augmented by applying pulsed electric fields directly to tumours after the administration of the drug. This treatment, known as electroche… |
| ECT | Chazal et al · Surgery | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – / 36 | T820 Electro Square Porator | bleomisin · intratümöral | tam yanıt 2 adet (9 hayvan) | Background Electrochemotherapy, which consist of local or systemic administration of a cytotoxic agent followed by application of electric pulses to a tumor, has proved effective for various… |
| ECT | Ramirez et al · Br J Cancer | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | Jouan PS 15 electropulsator, CELTEM MKO generator | bleomisin · intravenöz | tam yanıt 50% (10 hayvan) | Electrochemotherapy (ECT) is a new therapeutic approach combining the effects of a low-permeant cytotoxic drug, bleomycin (BLM), administered i.v. and cell-permeabilizing electric pulses (EP… |
| ECT | Jaroszeski et al · Biochim Biophys Acta | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | T820 | bleomisin · intratümöral | nesnel yanıt 84.6% (13 hayvan) | The use of in vivo electroporation in combination with a chemotherapeutic agent (electrochemotherapy) for the treatment of liver tumors was examined. Induced rat hepatomas were treated with … |
| Diğer EP | Alshahat et al · Applied Sciences | 2026 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Termal Etki ve Joule Isınması | – | – | – | – | Pulsed Electric Fields (PEFs) are widely investigated in cancer research, yet interpretation and optimisation of exposure protocols remain challenging due to the complex interplay between el… |
| Gen ET | Cash et al · Ann Biomed Eng | 2026 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | BTX ECM830, custom pulse generator | plazmid DNA | – | Purpose: To determine if GET via charge-balanced patterned bipolar microsecond pulses could be improved, novel bursts of patterned bipolar microsecond pulsed electric fields were investigate… |
| Kalsiyum EP | Lindelauf et al · Cardiovasc Intervent Radiol | 2024 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | – | Gemini Twin Wave Electroporator, BTX Electroporation Cuvette Plus | bleomisin · intratümöral | hücre canlılığı -1% (9 bildirilmemiş) | Purpose: Electrochemotherapy, clinically established for treating (sub)cutaneous tumors, has been standardized in the framework of the European Standard Operating Procedure on Electrochemoth… |
| IRE | Lindelauf et al · Technol Cancer Res Treat | 2023 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | hücre canlılığı 1% (9 bildirilmemiş) | Hepatocellular carcinoma is a leading cause of cancer-related death in many parts of the world. Traditional treatment options are not always effective. During the promising minimally invasiv… |
| IRE | Ding et al · Applied Sciences | 2023 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | The electroporation technique utilizes pulsed electric fields to induce porous defects in the cell membrane, and the technique can be used for delivering drugs into cells and killing cancer … |
| Diğer EP | Pelofy et al · Bioelectrochemistry | 2021 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | – | – | diğer · diğer yol | genel sağkalım 43% | The ability to modulate deregulated genes by RNAi provides treatment perspectives in certain diseases including cancers. Electrotransfer of oligonucleotides was studied in vitro, showing a d… |
| ECT | Šilkūnas et al · Bioelectrochemistry | 2021 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması | – | BTX ECM 2001 Electro Cell Manipulator | bleomisin | – | Bleomycin, which is the most widely used drugs in electrochemotherapy, requires oxygen to be able to make single- or double-strand brakes in DNA. However, the concentration of oxygen in tumo… |
| IRE | Fesmire et al · Ann Biomed Eng | 2020 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation is a bioelectric phenomenon used to deliver target molecules into cells in vitro and irreversible electroporation (IRE) is an emerging cancer therapy used to treat inoperable… |
| IRE | Zhang et al · Journal of Engineering and Science in Medical Diagnostics and Therapy | 2017 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | The purpose of this study was to investigate the feasibility of generating larger ablation volumes using the pulse delivery method in irreversible electroporation (IRE) using a potato model.… |
| IRE | Jiang et al · Ann Biomed Eng | 2013 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | tümör hacmi değişimi 10.3 cm³ | Irreversible electroporation (IRE) is a promising technology to treat local malignant cancer using short, high-voltage electric pulses. Unfortunately, in vivo studies show that IRE suffers f… |
| IRE | Adeyanju et al · Radiol Oncol | 2012 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Background: Irreversible electroporation (IRE) is a novel ablation tool that uses brief high-voltage pulses to treat cancer. The efficacy of the therapy depends upon the distribution of the … |
| Diğer EP | Mi et al · IEEE Trans. Dielect. Electr. Insul. | 2009 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu, Transmembran Potansiyel Değişimi | – | SPEF Generator | bleomisin | – | To research the apoptosis effects of steep pulsed electric fields (SPEF) on human liver cancer cell SMMC-7721in vitro, this paper studied phosphatidylserine (PS) externalization detection ut… |
| IRE | Sutter et al · Eur Radiol | 2025 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | 25 / 31 | NanoKnife | – | tam yanıt 93.5% (31 lezyon) | Objectives: Numerical evaluation of irreversible electroporation (IRE) holds significant potential to assist practitioners in planning and guiding these complex procedures. We aimed to estab… |
| IRE | Jouni · Technol Cancer Res Treat | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | – | – | – | – | Objectives: Irreversible Electroporation (IRE) is a non-thermal minimally invasive cancer therapy used in the treatment of liver tumors. However, the therapy entails an electrical current fl… |
| IRE | Vera-Tizatl · Bioeng Transl Med | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX Gemini X2 | – | ablasyon hacmi 94% (1 örnek) | Irreversible electroporation (IRE) has emerged as an appealing non-ionizing, non-thermal ablation therapy, independent of antineoplastic drugs. Limited but successful outcomes in IRE conduct… |
| IRE | van den Bemd et al · Radiol Imaging Cancer | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 202 / 611 | – | – | – | Purpose To further define anatomic criteria for resection and ablation using an expert panel-based three-dimensional liver model to objectively predict local treatment recommendations for co… |
| IRE | Cindric et al · IEEE Trans Biomed Eng | 2021 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | 18 / 18 | NanoKnife | – | tam yanıt 14 adet (18 hasta) | Objective: The aims of this study were to determine the electric field threshold that best fits the local response to irreversible electroporation (IRE) ablation of hepatic tumors as seen in… |
| Diğer EP | Perera-Bel et al · Comput Methods Programs Biomed | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Background and objectives: Electroporation is the phenomenon by which cell membrane permeability to ions and macromolecules is increased when the cell is briefly exposed to high electric fie… |
| Diğer EP | Gallinato et al · Math. Model. Nat. Phenom. | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electroporation ablation is a promising non surgical and minimally invasive technique of tumor ablation, for which no monitoring is currently available. In this paper, we present the recent … |
| IRE | Khorasani · Polish Journal of Medical Physics and Engineering | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Introduction: irreversible electroporation (IRE) is a tissue ablation technique and physical process used to kill the undesirable cells. In the IRE process by mathematical modelling we can c… |
| ECT | Pintar et al · Technol Cancer Res Treat | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | 1 / 1 | Cliniporator VITAE | bleomisin · intravenöz | lokal nüks 0% (1 hasta) | Electrochemotherapy and irreversible electroporation are gaining importance in clinical practice for the treatment of solid tumors. For successful treatment, it is extremely important that t… |
| IRE | Kos et al · Radiol Oncol | 2015 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | 1 / 1 | – | – | tümör hacmi değişimi 0.96 cm³ | Background: Irreversible electroporation (IRE) is a tissue ablation method, which relies on the phenomenon of electroporation. When cells are exposed to a sufficiently electric field, the pl… |
| IRE | Neal et al · IEEE Trans Biomed Eng | 2015 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) ablation uses brief electric pulses to kill a volume of tissue without damaging the structures contraindicated for surgical resection or thermal ablation, … |
| ECT | Pavliha et al · PLoS One | 2013 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation is the phenomenon that occurs when a cell is exposed to a high electric field, which causes transient cell membrane permeabilization. A paramount electroporation-based applic… |
| ECT | Kranjc et al · PLoS One | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | Cliniporator VITAE, Cliniporator | – | – | Magnetic resonance electrical impedance tomography (MREIT) was recently proposed for determining electric field distribution during electroporation in which cell membrane permeability is tem… |
| IRE | Stillström · Sci Rep | 2021 | Teknik / Cihaz Çalışması | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 55 | NanoKnife | – | – | The aim of this study was to compare the accuracy of stereotactic CT-guided navigation and ultrasound guided navigation for placing electrodes in Irreversible electroporation in a liver phan… |
| IRE | Qasrawi et al · Technol Cancer Res Treat | 2017 | Teknik / Cihaz Çalışması | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Irreversible electroporation is a novel tissue ablation technique which entails delivering intense electrical pulses to target tissue, hence producing fatal defects in the cell membrane. The… |
| Diğer EP | Bianchi et al · Mol Ther Oncol | 2026 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator | plazmid DNA · diğer yol | – | DNA electroporation of neoantigen cancer vaccine is a well-established approach to induce high expression of neoantigens and likely enlarge the immune response that is shaped by the vaccinat… |
| IRE | Gallagher et al · Journal of Vascular and Interventional Radiology | 2024 | Kongre Özeti | – | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 23 / 25 | – | – | tam yanıt 3 adet (23 hasta) | No. 159 Initial Experience with Microwave Ablation of Liver Malignancies with Concurrent Hepatic Artery Balloon Occlusion C. Chao1, M. Kim2, G. Li3, S. Park4; 1Harbor UCLA Medical Center; 2H… |
| IRE | Yu et al · Journal of Vascular and Interventional Radiology | 2023 | Kongre Özeti | – | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | No. 179 Percutaneous Placement of Lumen Apposing Metallic Stents for Patients with Afferent Loop Syndrome E. Klein1, L. Swanstrom2, C. Barragan1, H. Shmilovich3, E. Shlomovitz3; 1University … |
| IRE | Krishnan · World J Gastrointest Oncol | 2025 | Editöryal / Mektup | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | We read with great interest the recent article by Xing et al , which describes the synergy between irreversible electroporation and anti-programmed death-1 therapy in a murine hepatocellular… |
| ECT | Trotovšek et al · World J Gastroenterol | 2021 | Editöryal / Mektup | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin | – | Electrochemotherapy is a local ablative therapy that increases the cytotoxicity of either bleomycin or cisplatin by applying electric pulses (electroporation) to tumors. It has already been … |
| IRE | Pompili et al · J Ultrasound | 2019 | Editöryal / Mektup | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 16 / 18 | – | – | – | Maurizio Pompili1 · Giampiero Francica2 Received: 12 December 2018 / Accepted: 21 February 2019 / Published online: 6 March 2019 © Società Italiana di Ultrasonologia in Medicina e Biologia (… |
| IRE | Cheng · World J Surg Oncol | 2024 | Protokol | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 33 / 38 | steep pulse therapy system, RFA system, steep pulse therapy system produced by Zhejiang Ganevi Medic, RFA system produced by Covidien/Medtronic | – | tam yanıt 100% (33 hasta) | Background: At present, the main clinical application of local ablation therapy, such as radiofrequency ablation (RFA), is to heat the tissue to a certain temperature. However, high temperat… |
| Diğer EP | Aghayari · Results in Engineering | 2023 | Belirtilmemiş | – | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Nerve cancer is a highly lethal form of cancer that has proven difficult to effectively treat. A potential avenue for future research involves developing an effective treatment method for th… |
| IRE | Pan et al · – | 2023 | Protokol | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 33 / 38 | steep pulse therapy system | – | tam yanıt 100% (33 hasta) | Background At present, the main clinical application of local ablation therapy, such as radiofrequency ablation (RFA), is to heat the tissue to a certain temperature. However, high temperatu… |
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