Grup: Temel Bilimler
Genel Prensipler ve Biyofizik
Elektroporasyonun biyofiziği, darbe parametrelerinin hücre ve doku düzeyindeki etkileri, ilaç taşınım mekanizmaları ve tedavi planlaması bu alanda toplanır. Korpusun en geniş bölümüdür ve diğer tüm uygulama alanlarının dayandığı temel bilgiyi içerir.
968yayın kaydı
54klinik yayın kaydı
671preklinik yayın kaydı
165derleme
1988–2026yayın aralığı
Klinik yayın: randomize, prospektif ve retrospektif çalışma, vaka serisi ve vaka raporu. Preklinik yayın: hayvan, in vitro, modelleme ve deneysel biyofizik çalışmaları.
Yayınların Bildirdiği Klinik ve Teknik Veriler
Bu alandaki 968 yayının 961 tanesinde tam metinde bildirilen alanların toplamı. Sayılar toplanır, yorumlanmaz.
Yayınlarda bildirilen hasta sayılarının toplamı7.971 (58 yayında bildirilmiş)
Kohortu başka yayınlarla ilişkilendiren yayınkohort örtüşmesi olabilir (1)
Bildirilen toplam lezyon5.597 (56 yayında)
Kullanılan cihazlar (cihaz adı bildiren 454 yayın)Cliniporator (60) · BTX ECM830 (51) · NanoKnife (23) · Jouan GHT 1287 (17) · PS 15 (11) · Cliniporator VITAE (10)
Taşınan ajan ve yol (ajan bildiren 446 yayın)bleomisin (74) · bleomisin · intravenöz (72) · plazmid DNA · intratümöral (52) · plazmid DNA (41) · bleomisin · intratümöral (37) · plazmid DNA · diğer yol (30)
Erişim yolu (347 yayın bildiriyor)yüzeyel transkutanöz (153) · perkütan (132) · açık cerrahi (52) · endoskopik (5) · intraoperatif (3)
Görüntüleme kılavuzluğu (201 yayın bildiriyor)doğrudan görüş (98) · ultrason (71) · bilgisayarlı tomografi (57) · manyetik rezonans (30) · floroskopi (7)
Yanıt ölçütü (76 yayın bildiriyor)diğer (19) · histolojik (15) · WHO ölçütleri (8) · volumetrik (8) · klinik muayene (7)
Kombinasyon tedavisi (279 yayın bildiriyor)diğer kombinasyon (148) · sistemik kemoterapi (93) · diğer immünoterapi (47) · radyoterapi (25) · kontrol noktası inhibitörü (15)
Tekrar tedavi bildiren yayın77 / 606 yayın (355 yayın bu bilgiyi bildirmiyor)
Alan şiddeti1–19200 V/cm (403 kayıt, ortanca 1000)
Uygulanan gerilim1.5–10000 V (219 kayıt, ortanca 645)
Darbe sayısı1–10000 (590 kayıt, ortanca 8)
Darbe süresi0.01–1e+06 µs (591 kayıt, ortanca 100)
Toplamlar benzersiz hasta sayısı değildir: aynı kohort birden fazla yayında raporlanmış olabilir.
Yönteme Göre Literatür Durumu
Klinik yöntem başına yayın sayısı, klinik ve preklinik dağılım, literatür hacmi ve yayın aralığı. Sayfa girişindeki rozet yalnızca ECT kaydını özetler; yöntem ayrımının tamamı buradadır.
Elektrokemoterapi (ECT)
245yayın kaydı
28klinik yayın kaydı
150preklinik yayın kaydı
Keşifsel / düşük hacimli literatüreşik 8/245 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 0, preklinik 3.
1991–2026
İrreversible elektroporasyon (IRE)
211yayın kaydı
11klinik yayın kaydı
152preklinik yayın kaydı
Preklinik ağırlıklı literatüreşik 15/211 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 2, preklinik 10.
2005–2026
Pulsed-field ablasyon (PFA)
3yayın kaydı
0klinik yayın kaydı
2preklinik yayın kaydı
Keşifsel / düşük hacimli literatüreşik 0/3 kayıt
Bu yöntemin hiçbir kaydı hacim etiketine girmemiştir.
2022–2024
Kalsiyum elektroporasyonu
23yayın kaydı
0klinik yayın kaydı
18preklinik yayın kaydı
Keşifsel / düşük hacimli literatüreşik 1/23 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 0, preklinik 1.
2012–2026
Gen elektrotransferi
77yayın kaydı
0klinik yayın kaydı
63preklinik yayın kaydı
Keşifsel / düşük hacimli literatüreşik 3/77 kayıt
Bu sayının klinik ve preklinik dağılımı: klinik 0, preklinik 0.
1999–2026
Diğer elektroporasyon uygulamaları
400yayın kaydı
14klinik yayın kaydı
281preklinik yayın kaydı
Bu küme tek bir klinik yöntemi adlandırmaz; literatür hacmi atanmaz.
1988–2026
Yöntemi belirlenmemiş kayıtlar
9yayın kaydı
1klinik yayın kaydı
5preklinik yayın kaydı
Bu küme tek bir klinik yöntemi adlandırmaz; literatür hacmi atanmaz.
2011–2026
Özetlerde Anılan Mekanizmalar
Rakam, mekanizma adının geçtiği özet sayısıdır. Bir mekanizmanın anılması, o çalışmada gösterildiği anlamına gelmez.
Reversible Membran Permeabilizasyonu 412
İrreversible Por Oluşumu ve Hücre Ölümü 249
Elektrik Alan Dağılımı ve Modellemesi 204
Gen Elektrotransferi (Plazmid DNA) 174
Darbe Parametrelerinin Optimizasyonu 169
Doku İletkenliği ve Empedans Değişimi 125
Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu 118
Bleomisin Hücre İçi Birikiminin Artması 118
Elektrot Geometrisi ve Yerleşimi 108
Termal Etki ve Joule Isınması 69
Sisplatin Hücre İçi Birikiminin Artması 52
Apoptoz İndüksiyonu 46
Çalışma Tipi Dağılımı
Yüzde, alanın tamamındaki payı verir.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Randomize Klinik Çalışma | 1 | <%1 |
| Prospektif Klinik Çalışma | 7 | <%1 |
| Klinik Çalışma | 40 | %4 |
| Retrospektif Klinik Çalışma | 1 | <%1 |
| Vaka Serisi | 1 | <%1 |
| Vaka Raporu | 4 | <%1 |
| Sistematik Derleme / Meta-Analiz | 15 | %2 |
| Kılavuz / Uzlaşı | 2 | <%1 |
| Derleme | 150 | %15 |
| Hayvan Çalışması | 342 | %35 |
| İn Vitro Çalışma | 182 | %19 |
| İn Siliko / Modelleme | 112 | %12 |
| Teknik / Cihaz Çalışması | 21 | %2 |
| Deneysel Biyofizik Çalışması | 35 | %4 |
| Ön Baskı | 5 | <%1 |
| Tez | 1 | <%1 |
| Kongre Özeti | 10 | %1 |
| Editöryal / Mektup | 12 | %1 |
| Düzeltme / Erratum | 2 | <%1 |
| Belirtilmemiş | 25 | %3 |
Yayın Tablosu
968 yayın kaydı, çalışma tasarımına göre sıralanmıştır. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
Sınıflandırmalar otomatik üretilir ve tekil kayıtlarda hata içerebilir. Metodoloji
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Hasta / lezyon | Cihaz | Ajan ve yol | Bildirilen sonuç | Özet |
|---|---|---|---|---|---|---|---|---|---|---|
| Diğer EP | Hu et al · Medicine (Baltimore) | 2022 | Randomize Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması | 82 | G9805-C low-frequency electric pulse therapy instrument | – | – | To explore the efficacy of low-frequency electric pulse therapy (LFEPT) combined with 2 antiemetics in the prevention and treatment of cisplatin-based chemotherapy-induced nausea and vomitin… |
| ECT | Di Chiacchio et al · J Eur Acad Dermatol Venereol | 2019 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin | – | Background: Ungual warts are considered the most common benign nail tumour, and they are caused by the human papillomavirus. Despite the numerous treatments reported in the medical literatur… |
| ECT | Groselj et al · Cancer Chemother Pharmacol | 2016 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | 24 / 47 | Cliniporator | bleomisin · intravenöz | – | Purpose: With the aim to determine effective therapeutic window of electrochemotherapy, we analyzed bleomycin pharmacokinetic parameters in elderly patients. Methods: In prospective clinical… |
| Diğer EP | Meir et al · Biomed Microdevices | 2014 | Prospektif Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | A living cell placed in a high strength electric field, can undergo a process known as electroporation. It is believed that during electroporation nano-scale defects (pores) occur in the mem… |
| IRE | Thomson et al · J Vasc Interv Radiol | 2011 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 38 / 69 | NanoKnife | – | – | Purpose: A single-center prospective nonrandomized cohort study was performed to investigate the safety of irreversible electroporation (IRE) for tumor ablation in humans. Materials and meth… |
| Diğer EP | Davalos et al · IEEE Trans Biomed Eng | 2002 | Prospektif Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Molecular medicine involves the introduction of macromolecules, such as drugs or gene constructs, into specific cells of the body. Electroporation, which uses electric pulses to permeate cel… |
| Diğer EP | Zhang et al · Bioelectrochem Bioenerg | 1999 | Prospektif Klinik Çalışma | İnsan | – | – | ECM600 | diğer · topikal | – | It is now medically recognized that sagging skin and other signs of degenerative skin conditions, such as wrinkles and age spots, are caused primarily by oxy-radical damage. Vitamin C (Vit. … |
| ECT | C Domenge, S Orlowski, B Luboinski, T Baere, G Schwaab, J Belehradek · Cancer | 1996 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 7 | PS 15 | bleomisin · intravenöz | – | Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in… |
| ECT | Alkis et al · Inorganic Chemistry Communications | 2026 | Klinik Çalışma | İnsan | – | – | – | bleomisin | – | Bu yayında özet bulunmuyor. |
| Diğer EP | · – | 2026 | Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | – | – | – | – | The Unmet Need in Solid Tumor Immunotherapy approach combining bacterial outer membrane vesicles (OMVs), nucleic acid nanocarriers, and The advent of immune checkpoint inhibitors and electro… |
| ECT | Abadijoo et al · Sensors and Actuators A: Physical | 2025 | Klinik Çalışma | İnsan | – | – | Oncopore electroporation system | bleomisin · intratümöral | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Sutter et al · IEEE Trans Biomed Eng | 2024 | Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi | 1 / 1 | NanoKnife | – | – | In this article we investigate the possibility of using needles, which the interventional radiologist inserts near a deep-seated tumor during an electroporation-based therapy, to characteriz… |
| ECT | Odeyemi et al · IRJMETS | 2023 | Klinik Çalışma | İnsan | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – | developed electroporator | – | hücre canlılığı 71.83% | Electroporation is the process of temporarily creating openings in the cell membrane by exposing it to a shortterm electric field.In addition to creating openings in the membrane, electropor… |
| ECT | Rózsa et al · Orv Hetil | 2023 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 9 / 118 | Cliniporator | bleomisin · intravenöz | nesnel yanıt 96% (59 lezyon) | Introduction: The risk of cutaneous malignancies is significantly higher in immunosuppressed patients compared to the general population. These high-risk skin tumors tend to be aggressive, m… |
| ECT | Marcasciano et al · Eur J Plast Surg | 2022 | Klinik Çalışma | İnsan | – | – | – | – | – | Bu yayında özet bulunmuyor. |
| ECT | Pfefferle et al · J Dtsch Dermatol Ges | 2022 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | – | ePORE | bleomisin · intravenöz | – | Seit einigen Jahren besteht mit der Elektrochemotherapie (ECT) eine zusätzliche Therapieoption zur Behandlung kutaner und subkutaner Metastasen. Das Wirkungsprinzip dieses Verfahrens besteht… |
| ECT | Skorupska et al · Sensors and Actuators B: Chemical | 2022 | Klinik Çalışma | İnsan | – | – | Gene Pulser Xcell | bleomisin | – | Bu yayında özet bulunmuyor. |
| ECT | Groselj et al · Pharmaceutics | 2021 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 25 | Cliniporator | bleomisin · intravenöz | tam yanıt 89% (9 hasta) | The plasma concentration profile of bleomycin in the distribution phase of patients younger than 65 years is needed to determine the suitable time interval for efficient application of elect… |
| Diğer EP | Tartaglia et al · Clin Exp Dent Res | 2020 | Klinik Çalışma | İnsan | – | 22 | Velvet TMJ | diğer · topikal | ağrı yanıtı 100% (22 hasta) | Objective(s): It is well appreciated that traditional analgesic delivery routes used to treat pain associated with temporomandibular disorder (TMD) often have harmful unintended side effects… |
| IRE | Petrella et al · IEEE Trans Biomed Eng | 2020 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | – | ACE system | – | – | Objective: To evaluate the effect of a closed-loop temperature based feedback algorithm on ablative outcomes for pulsed electric field treatments. Methods: A 3D tumor model of glioblastoma w… |
| IRE | Sano et al · Ann Biomed Eng | 2020 | Klinik Çalışma | İnsan | Termal Etki ve Joule Isınması, Reversible Membran Permeabilizasyonu | – | Cool-Tip RF ACT1520 | – | – | Thermal tissue injury is an unintended consequence in current irreversible electroporation treatments due to the induction of Joule heating during the delivery of high voltage pulsed electri… |
| ECT | Anon · J. adv. ethnol. eng. res. | 2017 | Klinik Çalışma | İnsan | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | – | BTX Harvard Apparatus | bleomisin | hücre canlılığı 80.4% | Electrochemotherapy is a combined use of a chemotherapeutic drug and short intense electric ield for cancer treatment. The applied electric ield increases the permeability of the cell membra… |
| ECT | Grošelj et al · Clinical Therapeutics | 2017 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Few studies have assessed concentrations of fatty acid ethyl esters (FAEEs) after controlled administration of wide range of alcohol doses in both genders. The objective was to assess the ti… |
| IRE | Clark et al · HPB | 2017 | Klinik Çalışma | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | OPORATION (H-FIRE) IN A PORCINE PANCREATIC CANCER TREATMENT MODEL C. Clark, C. Byron, S. Bhonsle, M. Lorenzo, C. Arena, J. Robertson and R. Davalos Wake Forest Baptist Health, Winston Salem,… |
| ECT | Sundararajan · JCPCR | 2016 | Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin · intratümöral | tümör hacmi değişimi 1230 diğer | Electro oration is the application of electrical pulses for enhanced drug delivery. When used for delivering chemo drugs, it is called electrochemotherapy (ECT). For inoperable and chemo- an… |
| IRE | Bonakdar et al · Biophysical Journal | 2016 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Bu yayında özet bulunmuyor. |
| ECT | Quaglino et al · Acta Oncol | 2015 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | 121 | IGEA square wave electroporator | bleomisin · hem intravenöz hem intratümöral | ağrı yanıtı 74% (95 hasta) | Background: Electrochemotherapy describes the use of electric pulses to enhance chemotherapy uptake, and has proven highly efficient in treating cutaneous metastases. Patients referred for e… |
| ECT | Castiello et al · IEEE Trans. Dielect. Electr. Insul. | 2014 | Klinik Çalışma | İnsan | – | – | Cliniporator | – | – | Electrochemotherapy (ECT) is a local anticancer treatment for superficial tumors which involves the administration of a chemotherapeutic drug followed by short, high-voltage pulses. Incipien… |
| ECT | Valpione et al · Annals of Oncology | 2014 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 24 | – | bleomisin · intravenöz | tam yanıt 40% (10 hasta) | Background: electroporation, an effective drug delivery system, enhances the uptake of chemotherapeutic agents by means of short electrical fields which open transient pores on the cell memb… |
| ECT | O'Brien et al · J Immunother Cancer | 2014 | Klinik Çalışma | İnsan | – | – | – | – | – | Meeting abstracts The correlation between the level of immune involvement and immune cell infiltration within a treated tumour and the clinical outcome for patients has been well established… |
| ECT | Castiello et al · IEEE Trans. Dielect. Electr. Insul. | 2014 | Klinik Çalışma | İnsan | – | – | Cliniporator, laboratory voltage pulse generator | – | – | Electrochemotherapy (ECT) is a local anticancer treatment for superficial tumors which involves the administration of a chemotherapeutic drug followed by short, high-voltage pulses. Incipien… |
| IRE | Nielsen et al · Br J Anaesth | 2014 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Kas Kasılması ve Anestezi Gereksinimi | 28 | NanoKnife | – | – | Background Irreversible electroporation (IRE) is a novel tumour ablation technique involving repetitive application of electrical energy around a tumour. The use of pulsed electrical gradien… |
| IRE | Narayanan et al · Cardiovasc Intervent Radiol | 2014 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 101 / 129 | NanoKnife | – | – | Purpose: The purpose of the study was to evaluate the effect of Irreversible Electroporation (IRE) on vessel patency in close proximity to the ablation zone. Materials and methods: Between J… |
| IRE | Pavliha et al · J Membr Biol | 2013 | Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation-based treatment combining high-voltage electric pulses and poorly permanent cytotoxic drugs, i.e., electrochemotherapy (ECT), is currently used for treating superficial tumor… |
| Diğer EP | Diaz et al · J Transl Med | 2013 | Klinik Çalışma | İnsan | Gen Elektrotransferi (Plazmid DNA) | 33 | MedPulser | plazmid DNA · intratümöral | – | Background: DNA electroporation has been demonstrated in preclinical models to be a promising strategy to improve cancer immunity, especially when combined with other genetic vaccines in het… |
| ECT | Hampton · JAMA | 2011 | Klinik Çalışma | İnsan | – | – | – | bleomisin | – | FOR NEARLY 3 DECADES, BASIC SCIence researchers have used electric pulses to make cell membranes transiently permeable to deliver DNA and other molecules into cells. Now, clinical investigat… |
| ECT | Skarlatos et al · In Vivo | 2011 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | 52 | Cliniporator | bleomisin · hem intravenöz hem intratümöral | tam yanıt 63.83% (47 hasta) | Electrochemotherapy is currently undergoing intensive investigation in the field of local control of cancer. In Greece, five medical centers have co-operated to perform ECT for the efficient… |
| Diğer EP | Kotulska et al · Biophysical Journal | 2010 | Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Laufer et al · Physiol Meas | 2010 | Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | 6 / 14 | – | – | – | The four-electrode method was used to measure the ex vivo complex electrical impedance of tissues from 14 hepatic tumors and the surrounding normal liver from six patients. Measurements were… |
| ECT | Guida et al · European Journal of Cancer Supplements | 2008 | Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi | 17 | – | bleomisin · intravenöz | nesnel yanıt 80% (100 lezyon) | ECT is an effective local treatment for palliation on inoperable superficial neoplastic localizations which combines surgical debulking had a disease control for a long period (8 months, med… |
| ECT | Pavlovic et al · IEEE Trans Inf Technol Biomed | 2007 | Klinik Çalışma | İnsan | – | – | Cliniporator | bleomisin | – | Many branches of the healthcare industry are being influenced by information and communication technology (ICT). Clinical trials are not an exception. Despite this fact, more than 75% of cli… |
| ECT | Zupanic et al · Neoplasma | 2007 | Klinik Çalışma | İnsan | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | 40 | Cliniporator | – | – | Involuntary muscle contractions and painful sensations during electric pulse delivery are the most unpleasant side effects of electrochemotherapy. The aim of this study was to determine the … |
| Diğer EP | Ruggiero et al · Journal of the American Academy of Dermatology | 2005 | Klinik Çalışma | İnsan | – | – | – | diğer · topikal | – | T SKIN ELECTROPORATION Marco Ruggiero, MD, PhD, Department of Experimental Pathology and Oncology, Florence, Italy; Stefania Pacini, MD, PhD, Gianfranco Bernabei, Department of Anatomy, Hist… |
| IRE | Davalos et al · Ann Biomed Eng | 2005 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | This study introduces a new method for minimally invasive treatment of cancer-the ablation of undesirable tissue through the use of irreversible electroporation. Electroporation is the perme… |
| ECT | Spugnini et al · J Exp Clin Cancer Res | 2003 | Klinik Çalışma | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Chemopulse | bleomisin · intratümöral | tam yanıt 5 adet (17 hasta) | The objectives of this phase I/II study were: i) to determine whether electrochemotherapy (intralesional bleomycin + electric pulses) could be effective in companion animals with different, … |
| Diğer EP | Rabussay et al · Technol Cancer Res Treat | 2002 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 62 | – | bleomisin · intratümöral | nesnel yanıt 55% (17 hasta) | Many conventional chemotherapeutic drugs, as well as DNA for cancer gene therapy, require efficient access to the cell interior to be effective. The cell membrane is a formidable barrier to … |
| ECT | Daskalov et al · IEEE Eng Med Biol Mag | 1999 | Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | 42 / 96 | – | bleomisin · intratümöral | tam yanıt 2 adet (14 lezyon) | Electrochemotherapy using rectangular biphasic stimuli and bursts of stimuli, as compared to using monophasic pulses obtained by capacitor discharge, are at least of the same efficacy. The u… |
| ECT | Serša et al · Eur J Cancer | 1998 | Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 4 / 30 | Jouan GHT 1287 | sisplatin · intratümöral | tam yanıt 19 adet (19 lezyon) | This study was aimed at assessing the response to electrochemotherapy with cisplatin of cutaneous tumour nodules in patients with malignant melanoma, squamous cell carcinoma and basal cell c… |
| Diğer EP | Narayanan · Curr Oncol | 2025 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 132 / 224 | NanoKnife, ICEFX cryoablation system, Emprint microwave ablation system, NeuWave microwave ablation system, Solero microwave ablation device | – | lokal kontrol 120 adet (224 lezyon) | The purpose was to determine the ability of 18-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) scans performed within 24 h of percutaneous image-guided… |
| IRE | Ozdemir Simsek et al · BMC Anesthesiol | 2026 | Vaka Serisi | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | 12 | – | – | – | Background: Irreversible electroporation is a novel, non-thermal tumor ablation technique that induces cell death through electrical disruption of cellular membranes while preserving surroun… |
| Belirlenmedi | A Šenk Juh, B Šenk, M Čemažar · Medicinski razgledi | 2026 | Vaka Raporu | İnsan | – | 35 | – | plazmid DNA · intratümöral | – | – Amadej Šenk Juh, Barbara Šenk, Maja Čemažar 99 Diagnostični izziv 99 Diagnostic Challenge 105 Seznam diplomantov 105 List of Graduated Students 107 Navodila avtorjem 113 Guidelines for Aut… |
| IRE | Araújo et al · J Cardiothorac Vasc Anesth | 2025 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 2 | NanoKnife | – | – | Anesthesia for Irreversible Electroporation in Patients with a Pacemaker Guilherme Freitas Ara ujo, MD, TSA*, Marcelo Froeder Arcuri, MDy, Veronica Neves Fialho Queiroz, MD, PhD*, Guilherme… |
| ECT | Marandola et al · WJA | 2013 | Vaka Raporu | İnsan | – | – | Cliniporator VITAE | bleomisin · intravenöz | – | Electrochemotherapy and heart function: Treatment in a patient with implantable cardioverter defibrillator/pace-maker |
| Diğer EP | Daniels et al · PLoS One | 2011 | Vaka Raporu | İnsan | Kas Kasılması ve Anestezi Gereksinimi | – | Comsol Multiphysics | – | – | Pulsed electric fields (PEF) have become an important minimally invasive surgical technology for various applications including genetic engineering, electrochemotherapy and tissue ablation. … |
| ECT | Altamura et al · International Journal of Clinical Practice | 2026 | Sistematik Derleme / Meta-Analiz | İnsan | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 1387 | – | bleomisin | genel sağkalım 78.6% | Background Electrochemotherapy (ECT) is a nonthermal locoregional treatment that enhances cytotoxic drug uptake through reversible electroporation and is increasingly used across different m… |
| ECT | Formstone et al · Eur Radiol | 2026 | Sistematik Derleme / Meta-Analiz | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 127 | – | bleomisin · intravenöz | tam yanıt 97% | Objectives: To systematically review the available evidence on electrochemotherapy (ECT) in pediatric patients, focusing on indications, treatment parameters, efficacy, and safety. Materials… |
| ECT | Ferioli et al · Curr Oncol | 2023 | Sistematik Derleme / Meta-Analiz | İnsan | – | – | – | bleomisin | – | Radiotherapy (RT) and electrochemotherapy (ECT) are established local treatments for cancer. While effective, both therapies have limitations, especially in treating bulky and poorly oxygena… |
| IRE | Hogenes · Technol Cancer Res Treat | 2023 | Sistematik Derleme / Meta-Analiz | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması, Reversible Membran Permeabilizasyonu | – | – | – | – | Introduction: The aim of this study was to review the effect of irreversible electroporation parameter settings on the size of the ablation zone and the occurrence of thermal effects. This i… |
| Gen ET | Potočnik et al · Pharmaceutics | 2022 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | genel sağkalım 25% | The exact mechanisms of nucleic acid (NA) delivery with gene electrotransfer (GET) are still unknown, which represents a limitation for its broader use. Further, not knowing the effects that… |
| IRE | Granata et al · Int J Environ Res Public Health | 2021 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | bleomisin | – | Background: Imaging methods and the most appropriate criteria to be used for detecting and evaluating response to oncological treatments depend on the pathology and anatomical site to be tre… |
| IRE | Hilton et al · British Journal of Surgery | 2021 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 83 | – | – | tam yanıt 78% (55 hasta) | Introduction Thermal tumour ablation techniques are effective alternatives to nephrectomy for small renal masses (SRM). Thermal effects limit their use in tumours adjacent to vital structure… |
| IRE | Agnass et al · Int J Hyperthermia | 2020 | Sistematik Derleme / Meta-Analiz | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | – | – | – | – | Introduction: Irreversible electroporation (IRE) is a relatively new ablation method for the treatment of unresectable cancers. Although the main mechanism of IRE is electric permeabilizatio… |
| IRE | O'Neill et al · J Surg Oncol | 2020 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 481 | – | – | – | Background and objectives: Irreversible electroporation (IRE) is a nonthermal electrical tumor ablative strategy for unresectable tumors. IRE is relatively safe around critical structures bu… |
| ECT | Cen et al · J Healthc Eng | 2017 | Sistematik Derleme / Meta-Analiz | İnsan | Sinir ve Damar Yapılarının Korunması, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Pulsed electric field treatment is now widely used in diverse biological and medical applications: gene delivery, electrochemotherapy, and cancer therapy. This minimally invasive technique h… |
| ECT | Campana et al · Radiol Oncol | 2016 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | 1215 | – | bleomisin | – | Background: Electrochemotherapy is becoming a well-established treatment for malignancies of skin and non-skin origin and its use is widening across Europe. The technique was developed and o… |
| IRE | Vogel et al · PLoS One | 2016 | Sistematik Derleme / Meta-Analiz | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Apoptoz İndüksiyonu | – | – | – | – | Introduction: Irreversible electroporation (IRE) is a novel ablation technique in the treatment of unresectable cancer. The non-thermal mechanism is thought to cause mostly apoptosis compare… |
| ECT | Mali et al · Radiol Oncol | 2013 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Background: Electrochemotherapy (ECT) is an effective and safe method for local treatment of tumors. However, relatively large variability in effectiveness of ECT has been observed, which li… |
| ECT | Mali et al · Eur J Surg Oncol | 2013 | Sistematik Derleme / Meta-Analiz | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 413 / 1894 | – | – | nesnel yanıt 84.1% (1894 lezyon) | Background: This systematic review has two purposes: to consolidate the current knowledge about clinical effectiveness of electrochemotherapy, a highly effective local therapy for cutaneous … |
| ECT | Marone · J Clin Case Rep | 2012 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin · hem intravenöz hem intratümöral | – | Open Access Electrochemotherapy: A New Arm against Cancer Ugo Marone* Department of Surgery “Melanoma, Soft Tissues, Head and Neck and Skin Cancers” National Cancer Institute of Naples, Ital… |
| Diğer EP | Cemazar et al · Bioelectrochemistry | 2018 | Kılavuz / Uzlaşı | belirsiz | – | – | – | – | – | Electric field-induced membrane changes are an important approach in the life sciences. However, the developments in knowledge and translational applications face problems of reproducibility… |
| ECT | Mir et al · European Journal of Cancer Supplements | 2006 | Kılavuz / Uzlaşı | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin · hem intravenöz hem intratümöral | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Cai et al · Adv Mater | 2026 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | – | – | – | Inspired by endogenous physiological electric fields, electro-mediated therapeutic strategies represent promising approaches for targeted cancer therapy owing to their deep tissue penetratio… |
| Diğer EP | Hu et al · Research (Wash D C) | 2026 | Derleme | – | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | – | Bioelectronic patches have emerged as promising tools for localized and precise intracellular delivery. However, their application is limited by poor conformability and suboptimal delivery e… |
| ECT | Liu et al · Int. J. Extrem. Manuf. | 2026 | Derleme | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Microneedles (MNs) have emerged as a transformative minimally invasive platform in biomedicine, enabling painless transdermal drug delivery and diagnostic applications. However, conventional… |
| IRE | Miklavcic et al · Radiol Oncol | 2026 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Background: Electroporation-Based Treatments and Therapies (EBTTs) - electrochemotherapy, irreversible electroporation, pulsed field ablation, and gene electro-transfer - use short, high-vol… |
| IRE | Miklavčič · Bioelectrochemistry | 2026 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | bleomisin | – | Electroporation has birthed two massive parallel universes of applications: medicine and food processing. Despite operating on the same fundamental physics, these fields fail to crosspollina… |
| ECT | Saeed et al · J Control Release | 2026 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrik Alan Dağılımı ve Modellemesi | 4 | – | – | – | Tissue penetration of anticancer drugs is hindered by adverse biophysical properties of solid tumors, including elevated interstitial fluid pressure, dense extracellular matrices, and abnorm… |
| Diğer EP | Shi et al · Front Oncol | 2026 | Derleme | Literatür Analizi | İmmünojenik Hücre Ölümü (ICD), İmmün Kontrol Noktası İnhibitörü Kombinasyonu | – | – | – | – | Tumor Treating Fields (TTFields) and pulsed electric fields (PEF) have emerged as a fourth modality in oncological treatment, succeeding surgery, radiotherapy, and pharmacotherapy. However, … |
| Diğer EP | Tian et al · J Cancer Res Ther | 2026 | Derleme | Literatür Analizi | – | – | – | – | – | Background: Pulsed electric field (PEF) ablation is a promising nonthermal tumor treatment for liver cancer, recognized for its ability to induce immune responses. However, the field has lac… |
| Diğer EP | Truong et al · Biomater Res | 2026 | Derleme | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Reversible Membran Permeabilizasyonu | – | – | bleomisin | – | Electric field-based therapies are rapidly emerging as innovative modalities in the fight against cancer, offering targeted, minimally invasive, and often immunomodulatory alternatives to co… |
| Diğer EP | Zhou et al · Bio-des. Manuf. | 2026 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | plazmid DNA | – | Reversible electroporation (RE) involves applying pulsed electric fields to briefly disrupt cell membrane channels, allowing molecular transfer while preserving cell viability. Advances in R… |
| Diğer EP | Liu et al · Adv Drug Deliv Rev | 2026 | Derleme | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Termal Etki ve Joule Isınması | – | – | – | – | Intracellular delivery of therapeutic biomolecules represents a fundamental prerequisite for cell-based therapies and precision medicine, yet existing delivery methods present critical limit… |
| Diğer EP | Gehl et al · Radiol Oncol | 2026 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | bleomisin | – | The field of oncology has witnessed remarkable progress with the integration of high-tech innovations in tumor ablation. Tumor ablation therapies, such as radiofrequency ablation (RFA), micr… |
| IRE | Ji et al · Small | 2026 | Derleme | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | bleomisin | – | Electroporation has evolved from a membrane-permeabilization method into a versatile therapeutic platform for intracellular delivery, locoregional tumor intervention, and bioelectrically reg… |
| IRE | Liu · Prostate Int | 2026 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | lokal kontrol 5% (190 hasta) | Prostate cancer (PCa) is the second most commonly diagnosed malignancy in men. Radical treatments such as radical prostatectomy and radiotherapy can be associated with morbidity that impact … |
| IRE | Liu et al · iRADIOLOGY | 2026 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) is an emerging tumor ablation technique that induces permanent damage to cellular membranes through the application of high‐intensity short‐duration electr… |
| ECT | Morozas et al · Biomed Pharmacother | 2025 | Derleme | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | – | – | Electrochemotherapy (ECT) is a popular clinical anticancer treatment modality that combines chemotherapy with electroporation to enhance drug uptake by tumor cells. One of its key advantages… |
| Kalsiyum EP | Szewczyk et al · Biochim Biophys Acta Rev Cancer | 2025 | Derleme | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi | 6 | – | kalsiyum klorür · intratümöral | – | Calcium electroporation, an innovative technique, uses high-voltage pulses to introduce calcium ions into cells, leading to cell death and tumor growth inhibition. This review explores the p… |
| Gen ET | Jesenko · Radiol Oncol | 2025 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Background: Gene therapy has emerged as a transformative biomedical approach, offering new therapeutic possibilities from many so far uncurable diseases through the introduction of recombina… |
| ECT | Ferioli et al · Technol Cancer Res Treat | 2025 | Derleme | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin · intravenöz | nesnel yanıt 82.6% (23 hasta) | This narrative review explores the potential role of electrochemotherapy (ECT) in treating anorectal tumors, focusing on its effectiveness, feasibility, and associated toxicities. ECT, which… |
| Diğer EP | Chikovani et al · Vaccines (Basel) | 2025 | Derleme | Literatür Analizi | İmmünojenik Hücre Ölümü (ICD), İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Cancer immunotherapy has redefined oncology's goals, aiming for durable systemic immunity rather than mere cytoreduction. However, many solid tumors remain refractory due to immunosuppressiv… |
| IRE | Vallin et al · Annu Rev Chem Biomol Eng | 2025 | Derleme | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 92 | – | – | – | Irreversible electroporation (IRE) is a nonthermally mediated tissue ablation modality that makes use of short pulsed electric fields to destroy cancerous lesions in situ. In the past two de… |
| Gen ET | Shiwani et al · Br J Radiol | 2024 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | nesnel yanıt 81.9% (3729 hasta) | Reversible electroporation (EP) refers to the use of high-voltage electrical pulses on tissues to increase cell membrane permeability. It allows targeted delivery of high concentrations of c… |
| Diğer EP | Taghdiri et al · Int J Mol Sci | 2024 | Derleme | Hayvan (İn Vivo) | – | – | – | bleomisin | – | Clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has revolutionized the field of gene therapy as it has enabled precise genom… |
| Diğer EP | Zhou et al · Adv Sci (Weinh) | 2024 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Intracellular delivery of nano-drug-carriers (NDC) to specific cells, diseased regions, or solid tumors has entered the era of precision medicine that requires systematic knowledge of nano-b… |
| ECT | Ferioli et al · Curr Oncol | 2024 | Derleme | Hayvan (İn Vivo) | Sistemik / Abskopal İmmün Yanıt, İmmünojenik Hücre Ölümü (ICD) | – | – | bleomisin | – | Electrochemotherapy (ECT) is an emerging therapeutic approach gaining growing interest for its potential immunomodulatory effects in cancer treatment. This narrative review systematically ex… |
| ECT | Hadzialjevic et al · Front Immunol | 2024 | Derleme | İnsan | İmmünojenik Hücre Ölümü (ICD), Sistemik / Abskopal İmmün Yanıt | – | – | bleomisin · intravenöz | – | Electrochemotherapy is a novel, locoregional therapy that is used to treat cutaneous and deep-seated tumors. The electric pulses used in electrochemotherapy increase the permeability of the … |
| IRE | De Cillis et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2024 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | The adoption of high-frequency irreversible electroporation in various medical treatments is becoming increasingly prevalent. There is currently a special focus on its applications in oncolo… |
| Diğer EP | Zhao · Phenomics | 2024 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Pyroptosis is a newly recognized type of programmed cell death mediated by the gasdermin family and caspase. It is characterized by the formation of inflammasomes and the following inflammat… |
| Diğer EP | Brno University of Technology · – | 2023 | Derleme | Literatür Analizi | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation utilizes high-intensity voltage pulses to permeabilize the cell membranes, serving as a staple technique across biotechnology and medicine. While the primary mechanism - pore… |
| Kalsiyum EP | Campana et al · Cancers (Basel) | 2023 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | The 4th World Congress of Electroporation (Copenhagen, 9-13 October 2022) provided a unique opportunity to convene leading experts in pulsed electric fields (PEF). PEF-based therapies harnes… |
| ECT | Ottlakan et al · Electrochem | 2023 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · hem intravenöz hem intratümöral | – | Electrochemotherapy (ECT) has evolved significantly during the last decade, expanding treatment indications from superficial skin lesions to advanced-stage, deep-seated tumors in hard-to-rea… |
| Diğer EP | Qian et al · Biomed Tech (Berl) | 2023 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Objectives: Electroporation, the breakdown of the biomembrane induced by external electric fields, has increasingly become a research hotspot for its promising related methods in various kin… |
| Diğer EP | Campelo et al · Annu Rev Biomed Eng | 2023 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin | – | Over the past decade, the increased adoption of electroporation-based technologies has led to an expansion of clinical research initiatives. Electroporation has been utilized in molecular bi… |
| ECT | Kis et al · BVSZ | 2023 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | nesnel yanıt 79.4% | Electrochemotherapy is a widely used locoregional method for the treatment of superficial tumors with different histologies. During treatment, a chemotherapeutic drug, usually bleomycin, is … |
| ECT | Condello et al · Cancers (Basel) | 2022 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Electrochemotherapy (ECT) is one of the innovative strategies to overcome the multi drug resistance (MDR) that often occurs in cancer. Resistance to anticancer drugs results from a variety o… |
| IRE | Tasu et al · Diagn Interv Imaging | 2022 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | bleomisin | – | Thermal tumor ablation techniques including radiofrequency, microwave, LASER, high-intensity focused ultrasound and cryoablation are routinely used to treated liver, kidney, bone, or lung tu… |
| ECT | Tsoneva et al · Biophys Chem | 2022 | Derleme | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin | – | This review focuses on electrochemotherapy that consists in the delivery of anti-cancer drugs using high-voltage electrical pulses. Technical issues, choice of drugs, and protocol of drug de… |
| ECT | Bendix et al · Eur J Surg Oncol | 2022 | Derleme | İnsan | Sistemik / Abskopal İmmün Yanıt | – | – | bleomisin · intravenöz | – | Electrochemotherapy (ECT), the application of an electric impulse to deliver chemotherapy drugs into cells, has been in clinical trials since the early 1990s and has been used for a variety … |
| ECT | Das et al · Front Bioeng Biotechnol | 2022 | Derleme | Literatür Analizi | İmmünojenik Hücre Ölümü (ICD) | 8 / 11 | – | bleomisin · intravenöz | – | Immunotherapy is becoming a very common treatment for cancer, using approaches like checkpoint inhibition, T cell transfer therapy, monoclonal antibodies and cancer vaccination. However, the… |
| Gen ET | Sachdev et al · Bioelectrochemistry | 2022 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Gene therapies are revolutionizing medicine by providing a way to cure hitherto incurable diseases. The scientific and technological advances have enabled the first gene therapies to become … |
| Gen ET | Rakoczy et al · Applied Sciences | 2022 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Electroporation (EP) allows for the transport of molecules into the cytoplasm with significant effectiveness by forming transient pores in the cell membrane using electric pulses. This can b… |
| IRE | Gong · Vaccines (Basel) | 2022 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Apoptoz İndüksiyonu | – | – | – | – | Electroporation is the process of instantaneously increasing the permeability of a cell membrane under a pulsed electric field. Depending on the parameters of the electric pulses and the tar… |
| PFA | Wang · Front Oncol | 2022 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Pulsed field ablation can increase membrane permeability and is an emerging non-thermal ablation. While ablating tumor tissues, electrical pulses not only act on the membrane structure of ce… |
| IRE | Zhang et al · Front Immunol | 2022 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE), a novel non-thermal ablation technique, is utilized to ablate unresectable solid tumors and demonstrates favorable safety and efficacy in the clinic. IRE … |
| ECT | Fusco et al · World J Clin Oncol | 2021 | Derleme | İnsan | Kas Kasılması ve Anestezi Gereksinimi, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin · intravenöz | – | Background: In the first studies of electrochemotherapy (ECT), small cutaneous metastases were treated and only mild or moderate pain was observed; therefore, pain was not considered a signi… |
| Diğer EP | Aguilar et al · Cancers (Basel) | 2021 | Derleme | Literatür Analizi | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | The biological impact of exogenous, alternating electric fields (AEFs) and direct-current electric fields has a long history of study, ranging from effects on embryonic development to influe… |
| Diğer EP | Balantič et al · Acta Chim Slov | 2021 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Electroporation is used to increase the permeability of the cell membrane through high-voltage electric pulses. Nowadays, it is widely used in different areas, such as medicine, biotechnolog… |
| ECT | Bonferoni et al · Cancers (Basel) | 2021 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Surgical resection is the gold standard for the treatment of many kinds of tumor, but its success depends on the early diagnosis and the absence of metastases. However, many deep-seated tumo… |
| Diğer EP | Hur et al · Adv Sci (Weinh) | 2021 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | – | Innate cell function can be artificially engineered and reprogrammed by introducing biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the cytosol or nucleus. T… |
| Gen ET | Luz et al · Vaccines (Basel) | 2021 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | – | – | Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique… |
| Diğer EP | Batista Napotnik et al · Bioelectrochemistry | 2021 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | diğer | – | Exposure of cells to high voltage electric pulses increases transiently membrane permeability through membrane electroporation. Electroporation can be reversible and is used in gene transfer… |
| Diğer EP | Khaorasani · fbt | 2021 | Derleme | Literatür Analizi | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electric field intensity at each point is responsible for pore creation in the cell membrane during the electroporation process. These pores can increase the tissue electrical conductivity i… |
| ECT | Sersa et al · Eur J Surg Oncol | 2021 | Derleme | İnsan | Ekstraselüler Matriks ve Doku İskeletinin Korunması | – | – | bleomisin · intratümöral | – | The beneficial effects of electrochemotherapy (ECT) for superficial tumours and, more recently, deep-seated malignancies in terms of local control and quality of life are widely accepted. Ho… |
| Diğer EP | Brock et al · Front Oncol | 2020 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | New therapeutic strategies and paradigms are direly needed for the treatment of cancer. While the surgical removal of tumors is favored in most cancer treatment plans, resection options are … |
| IRE | Graybill et al · Cancers (Basel) | 2020 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the trea… |
| ECT | Celik ve Bektas · HEAD | 2020 | Derleme | Literatür Analizi | – | – | – | bleomisin · intravenöz | – | Elektrokemoterapi farklı histolojilerdeki tümörlerin tedavisinde kemoterapi ilaçlarının elektroporasyon yöntemiyle uygulanmasıdır. Elektroporasyon ile hücre membranının geçirgenliği artırılı… |
| Gen ET | Geboers et al · Radiology | 2020 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). HVE… |
| Diğer EP | Gantenbein et al · Front Bioeng Biotechnol | 2020 | Derleme | Literatür Analizi | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | – | Viral carrier transport efficiency of gene delivery is high, depending on the type of vector. However, viral delivery poses significant safety concerns such as inefficient/unpredictable repr… |
| Diğer EP | Cvetkoska et al · IEEE Instrum. Meas. Mag. | 2020 | Derleme | Literatür Analizi | – | – | – | bleomisin | – | Cell exposure to high-voltage, short-duration electric pulses can lead to temporary formation of hydrophilic pores in the plasma membrane and an increase in the membrane's permeability which… |
| Diğer EP | Dermol-Černe et al · Expert Opin Drug Deliv | 2020 | Derleme | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Introduction : Skin electroporation is a promising treatment for transdermal drug delivery, gene electrotransfer, skin rejuvenation, electrochemotherapy, and wound disinfection. Although a c… |
| Kalsiyum EP | Frandsen et al · Cancers (Basel) | 2020 | Derleme | Literatür Analizi | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Sistemik / Abskopal İmmün Yanıt | – | – | kalsiyum klorür · intratümöral | – | Calcium electroporation is a potential novel anti-cancer treatment where high calcium concentrations are introduced into cells by electroporation, a method where short, high voltage pulses i… |
| Diğer EP | Pirc et al · Journal of Medical Devices | 2020 | Derleme | Literatür Analizi | Darbe Parametrelerinin Optimizasyonu | – | – | bleomisin · intravenöz | – | Electroporation-based therapies have a huge potential for implementation into clinical practice in socioeconomically disadvantaged populations. Currently, the price of electroporators and el… |
| ECT | Cemazar et al · Bioelectricity | 2019 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Electrochemotherapy is gaining recognition as an effective local therapy that uses systemically or intratumorally injected bleomycin or cisplatin with electroporation as a delivery system th… |
| Diğer EP | Nuccitelli · Bioelectricity | 2019 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | bleomisin | – | This review covers the use of pulsed electric fields in cancer therapy. It is organized into three sections based on pulse length, millisecond domain, microsecond domain, and nanosecond doma… |
| Diğer EP | Kotnik et al · Annu Rev Biophys | 2019 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | – | – | – | – | Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient increase in their plasma membrane permeability, allowing transmembrane transport of otherwise … |
| Diğer EP | Sokołowska et al · Int J Mol Sci | 2019 | Derleme | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi | – | – | plazmid DNA · diğer yol | – | The gene delivery to skeletal muscles is a promising strategy for the treatment of both muscular disorders (by silencing or overexpression of specific gene) and systemic secretion of therape… |
| ECT | Esmaeili et al · J Healthc Eng | 2019 | Derleme | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | 376 / 57 | – | bleomisin · intravenöz | nesnel yanıt 85% (100 hasta) | The efficiency of electroporation (EP) has made it a widely used therapeutic procedure to transfer cell killing substances effectively to the target site. A lot of researches are being done … |
| IRE | Chen · Technol Cancer Res Treat | 2019 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – / 47 | – | – · intravenöz | tam yanıt 85% (16 hasta) | Irreversible electroporation has raised great interest in the past decade as a means of destroying cancers in a way that does not involve heat. Irreversible electroporation is a novel ablati… |
| Gen ET | Batista Napotnik et al · Bioelectrochemistry | 2018 | Derleme | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Exposing cells to an electric field leads to electroporation of the cell membrane which has already been explored and used in a number of applications in medicine and food biotechnology (e.g… |
| Diğer EP | Cervia et al · Mol Pharm | 2018 | Derleme | Literatür Analizi | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Electrotransfection (ET) is a nonviral method for delivery of various types of molecules into cells both in vitro and in vivo. Close to 90 clinical trials that involve the use of ET have bee… |
| ECT | Probst et al · Technol Cancer Res Treat | 2018 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 10 / 17 | – | – | – | Electroporation is a well-known phenomenon that occurs at the cell membrane when cells are exposed to high-intensity electric pulses. Depending on electric pulse amplitude and number of puls… |
| Diğer EP | Shi et al · Molecules | 2018 | Derleme | Hayvan (İn Vivo) | – | – | – | – | – | Intracellular delivery is a critical step in biological discoveries and has been widely utilized in biomedical research. A variety of molecular tools have been developed for cell-based gene … |
| IRE | Fuhrmann et al · Technol Cancer Res Treat | 2018 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | The application of navigational systems has the potential to improve percutaneous interventions. The accuracy of ablation probe placement can be increased and radiation doses reduced. Two di… |
| IRE | Meijerink et al · – | 2018 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Martijn R. Meijerink Hester J. Scheffer Govindarajan Narayanan Editors 123 Irreversible Electroporation in Clinical Practice Martijn R. Meijerink • Hester J. Scheffer Govindarajan Narayanan … |
| Kalsiyum EP | Frandsen et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | – | – | kalsiyum klorür · intratümöral | – | Electrochemotherapy is an anticancer treatment inducing uptake of chemotherapeutics by electroporation. This treatment is increasingly being used clinically and further investigations for im… |
| ECT | Gehl et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | – | – | – | bleomisin · intravenöz | tam yanıt 73% | Electrochemotherapy has grown out of simple cell experiments through preclinical studies to experimental clinical studies, to an accepted treatment modality for cutaneous metastases for any … |
| ECT | Kranjc et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | diğer | – | Radiotherapy is the use of ionizing radiation in the treatment of malignant tumors. It is one of the main treatment modalities for many forms of cancer, with more than half of all cancer pat… |
| IRE | Markelc et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation/electropermeabilization (EP), achieved by application of electric pulses to cells or tissues, induces reversible permeabilization of cell membranes under suitable conditions,… |
| ECT | Serša et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Vasküler Kilit (Vascular Lock) Etkisi, Reversible Membran Permeabilizasyonu | – | – | bleomisin · intravenöz | – | Electroporation/electropermeabilization (EP), achieved by application of electric pulses to cells or tissues, induces reversible permeabilization of cell membranes under suitable conditions,… |
| ECT | Serša et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Electrochemotherapy is the combination of chemotherapy and local application of electric pulses. Application of electric pulses, i.e., electroporation, is used as a means to increase drug de… |
| Diğer EP | De Robertis et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | – | Emerging strategies in cancer treatments, such as gene electrotransfer and electrochemotherapy, are very promising. However, preclinical studies of effective therapeutic agents delivered in … |
| ECT | Kamensek et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Sistemik / Abskopal İmmün Yanıt | – | – | bleomisin · intravenöz | – | Harnessing the body’s own immune system to fight cancer is one of the most encouraging fields of cancer research today. Promising new cancer immunotherapies are currently being tested in precl… |
| ECT | Todorovic et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, İnterlökin-12 Aracılı İmmün Uyarım | – | – | bleomisin · intravenöz | – | Electrochemotherapy is a nonthermal tumor ablation modality. The local delivery of electric pulses directly to the tumor transiently increases permeabilization of the cell membrane and signi… |
| IRE | Kos · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | – | bleomisin | – | Electrochemotherapy and irreversible electroporation can be used to treat deepseated tumors. Key to treatment success is ensuring that the entirety of the target tumor is covered with electr… |
| IRE | Bhonsle et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) employs a series of brief electric pulses to destabilize cell membranes by altering the transmembrane voltage to create nanoscale defects that induce cell … |
| IRE | Mucciardi et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | diğer | – | Irreversible electroporation (IRE) and cryoablation (Cryo) are, among the many others in use, respectively, the youngest and the oldest tissue ablation modalities. No other treatment has spr… |
| IRE | Rolong et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | The phenomenon of electroporation can be traced back to the eighteenth century when red spots on skin (Lichtenberg figures) were observed in the areas where electric fields were applied. Once … |
| IRE | Thomson et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | tam yanıt 25 adet (46 lezyon) | Irreversible electroporation (IRE) for focal tumor control has developed since early human studies in 2009 to a point where it is now a useful part of the tumor eradication algorithm. While … |
| IRE | Vroomen et al · Diagn Interv Imaging | 2017 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Focal treatment with radiofrequency, microwave and cryoablation has been increasingly used for the treatment of tumors in patients who cannot undergo surgical resection and in select patient… |
| ECT | Calvet et al · Cancer Metastasis Rev | 2016 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin | – | Anti-tumor electrochemotherapy, which consists in increasing anti-cancer drug uptake by means of electroporation, is now implanted in about 140 cancer treatment centers in Europe. Its use is… |
| Gen ET | Rosazza · Curr Gene Ther | 2016 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | – | plazmid DNA | – | Gene electrotransfer is a powerful method of DNA delivery offering several medical applications, among the most promising of which are DNA vaccination and gene therapy for cancer treatment. … |
| IRE | Savic et al · Rofo | 2016 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 174 / 174 | – | – | tam yanıt 79% (29 lezyon) | Unlabelled: Irreversible electroporation (IRE) is the latest in the series of image-guided locoregional tumor ablation therapies. IRE is performed in a nearly non-thermal fashion that circum… |
| IRE | Wagstaff et al · Onco Targets Ther | 2016 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | The field of focal ablative therapy for the treatment of cancer is characterized by abundance of thermal ablative techniques that provide a minimally invasive treatment option in selected tu… |
| Diğer EP | Pavšelj et al · J Biomech Eng | 2015 | Derleme | Literatür Analizi | – | – | – | – | – | In this paper, we discuss some of the primary experimental factors that should be considered when interpreting and implementing the published results of skin electroporation studies concerni… |
| Diğer EP | Lambricht et al · Expert Opin Drug Deliv | 2015 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Introduction: Electroporation allows efficient delivery of DNA into cells and tissues, thereby improving the expression of therapeutic or immunogenic proteins that are encoded by plasmid DNA… |
| Diğer EP | Lee et al · Hum Vaccin Immunother | 2015 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | – | Numerous animal studies and recent clinical studies have shown that electroporation-delivered DNA vaccines can elicit robust Ag-specific CTL responses and reduce disease severity. However, c… |
| IRE | Jiang et al · IEEE Trans Biomed Eng | 2015 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 38 / 69 | – | bleomisin | – | The use of irreversible electroporation (IRE) for cancer treatment has increased sharply over the past decade. As a nonthermal therapy, IRE offers several potential benefits over other focal… |
| IRE | Narayanan · Semin Intervent Radiol | 2015 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) is a predominantly nonthermal ablative technology that uses high-voltage, low-energy DC current pulses to induce cell death. Thermal ablative technologies … |
| ECT | Cadossi et al · Future Oncol | 2014 | Derleme | İnsan | Sistemik / Abskopal İmmün Yanıt | – | – | bleomisin · intravenöz | nesnel yanıt 84.8% | Electroporation is used to enhance drug diffusion and gene delivery into the cytosol. The combination of electroporation and cytotoxic drugs, electrochemotherapy (ECT), is used to treat meta… |
| ECT | Miklavčič et al · Biomed Eng Online | 2014 | Derleme | İnsan | – | – | – | bleomisin · intravenöz | nesnel yanıt 84.1% (1894 lezyon) | Electrochemotherapy is a local treatment of cancer employing electric pulses to improve transmembrane transfer of cytotoxic drugs. In this paper we discuss electrochemotherapy from the persp… |
| ECT | O’Sullivan · Electroporation-Based Therapies for Cancer | 2014 | Derleme | Literatür Analizi | – | – | – | bleomisin | – | There are so many cancer patients for whom the current standard of cure doesn’t work. Electrochemotherapy could serve as an attractive alternative to many of these patients who have inoperab… |
| Diğer EP | Yarmush et al · Annu Rev Biomed Eng | 2014 | Derleme | Hayvan (İn Vivo) | – | – | – | bleomisin · intravenöz | nesnel yanıt 84.1% | When high-amplitude, short-duration pulsed electric fields are applied to cells and tissues, the permeability of the cell membranes and tissue is increased. This increase in permeability is … |
| Diğer EP | Calvet et al · Oncoimmunology | 2014 | Derleme | belirsiz | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | DNA vaccination consists of administering an antigen-coding nucleotide sequence. In order to improve the efficacy of DNA vaccines, electroporation is one of the most commonly used methods to… |
| IRE | Deipolyi et al · Diagn Interv Radiol | 2014 | Derleme | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in … |
| IRE | Jourabchi et al · Gastrointestinal Intervention | 2014 | Derleme | belirsiz | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 13 | – | – | – | Irreversible electroporation (IRE) is a promising new minimally invasive modality for the ablation of solid tumors. Unlike the current leading thermal ablation modalities, such as radiofrequ… |
| IRE | Silk et al · Semin Intervent Radiol | 2014 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | tam yanıt 50% (10 lezyon) | A new ablation modality, irreversible electroporation (IRE), has been of increasing interest in interventional radiology. Its nonthermal mechanism of action of killing tumor cells allows phy… |
| Diğer EP | Geng et al · Lab Chip | 2013 | Derleme | Hayvan (İn Vivo) | – | – | – | – | – | Electroporation is a simple yet powerful technique for breaching the cell membrane barrier. The applications of electroporation can be generally divided into two categories: the release of i… |
| Diğer EP | Aurisicchio et al · Expert Rev Vaccines | 2013 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Therapeutic vaccination could become an important modality to fight cancer. Efficacious immune responses against cancer cells have to be directed simultaneously against multiple epitopes bel… |
| Diğer EP | Chabot et al · Pharmaceuticals (Basel) | 2013 | Derleme | belirsiz | Reversible Membran Permeabilizasyonu | – | – | – | – | For more than a decade, understanding of RNA interference (RNAi) has been a growing field of interest. The potent gene silencing ability that small oligonucleotides have offers new perspecti… |
| Diğer EP | Chiarella et al · Curr Drug Metab | 2013 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Since conventional therapeutic approaches in cancer are highly invasive they hardly prolong patient survival for more than few months. Having the ability to stimulate both cellular and humou… |
| IRE | Golberg et al · IEEE Trans Biomed Eng | 2013 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Tissue ablation is an essential procedure for the treatment of many diseases. In the last decade, a nonthermal tissue ablation using intensive pulsed electric fields, called nonthermal irrev… |
| ECT | Escoffre et al · curr pharm des | 2012 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | 2000 | – | bleomisin · intravenöz | nesnel yanıt 80% | Treatment of recurrent or unresectable cutaneous and subcutaneaous tumors continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a palliative treatment of cutaneous and … |
| ECT | Miklavčič et al · Med Biol Eng Comput | 2012 | Derleme | Hayvan (İn Vivo) | Ekstraselüler Matriks ve Doku İskeletinin Korunması, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electrochemotherapy, a combination of high voltage electric pulses and of an anticancer drug, has been demonstrated to be highly effective in treatment of cutaneous and subcutaneous tumors. … |
| Diğer EP | Cha et al · Hum Vaccin Immunother | 2012 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | – | – | plazmid DNA · intratümöral | – | Intratumoral gene electroporation uses electric charges to facilitate entry of plasmid DNA into cells in a reproducible and highly efficient manner, especially to accessible sites such as cu… |
| Diğer EP | Gothelf et al · Hum Vaccin Immunother | 2012 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · intratümöral | – | Vaccinations are increasingly used to fight infectious disease, and DNA vaccines offer considerable advantages, including broader possibilities for vaccination and lack of need for cold stor… |
| Belirlenmedi | Impellizeri et al · Vet Comp Oncol | 2012 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | bleomisin | – | The concept of vaccines based on the direct inoculation of plasmid DNA gained initial proof-of-concept in small rodent species. Further development was hampered by the difficulty to confirm … |
| Diğer EP | Spugnini · BioMed Eng OnLine | 2011 | Derleme | Literatür Analizi | – | – | – | – | – | This article is a review of the book: Clinical aspects of electroporation, by Stephen T. Kee, Julie Gehl, Edward W Lee, which is published by Springer Press. Basic information that should be… |
| Diğer EP | Murakami et al · Curr Gene Ther | 2011 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | 120 | – | plazmid DNA | nesnel yanıt 65% (120 hasta) | Simple plasmid DNA injection is a safe and feasible gene transfer method, but it confers low transfection efficiency and transgene expression. This non-viral gene transfer method is enhanced… |
| Gen ET | Cemazar et al · Curr Gene Ther | 2010 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | – | – | plazmid DNA | – | Electrogene therapy combines administration of plasmid DNA into tissue followed by local application of electric pulses. In electrogene therapy with interleukin-12 (IL-12), different routes … |
| Diğer EP | Yuan et al · Int Arch Med | 2010 | Derleme | Literatür Analizi | – | – | – | plazmid DNA | – | The development and application of single neuron electroporation largely advanced the use of traditional genetics in investigations of the central nervous system. This quick and accurate man… |
| Diğer EP | Becker · Journal of Heat Transfer | 2010 | Derleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Skin electroporation is an approach used to enhance the transdermal transport of large molecules in which the skin is exposed to a series of electric pulses, resulting in the structural alte… |
| IRE | Lee et al · Gut Liver | 2010 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) is a novel tumor ablation technique using a non-thermal energy to create innumerable permanent nanopores in the cell membrane to disrupt cellular homeostas… |
| Diğer EP | Tang et al · Biochem Biophys Res Commun | 2009 | Derleme | Hücre Kültürü | Apoptoz İndüksiyonu | – | – | – | – | Electrical pulses have been widely used in biomedical fields, whose applications depend on the parameters such as durations and electric intensity. Conventional electroporation (0.1-1kV/cm, … |
| Diğer EP | Villemejane et al · Br J Pharmacol | 2009 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Physical methods of gene (and/or drug) transfer need to combine two effects to deliver the therapeutic material into cells. The physical methods must induce reversible alterations in the pla… |
| ECT | Sadadcharam et al · Int J Hyperthermia | 2008 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin · intravenöz | nesnel yanıt 85% | Purpose: The aim of this review article is to provide a concise overview of the pre-clinical development of electrochemotherapy (ECT), its present utility in clinical practice and to examine… |
| ECT | Sersa et al · Eur J Surg Oncol | 2008 | Derleme | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Reversible Membran Permeabilizasyonu | – / 1180 | – | diğer · hem intravenöz hem intratümöral | genel sağkalım 75% (1180 lezyon) | Aim: Electrochemotherapy is a local drug delivery approach aimed at treatment with palliative intent of cutaneous and subcutaneous tumour nodules of different histologies. Electrochemotherap… |
| Diğer EP | Escoffre et al · Mol Biotechnol | 2008 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | – | bleomisin | – | Cell membranes can be transiently permeabilized under application of electric pulses. This treatment allows hydrophilic therapeutic molecules, such as anticancer drugs and DNA, to enter into… |
| Gen ET | Cemazar et al · Curr Opin Mol Ther | 2007 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Electroporation is a physical method for the delivery of various molecules into cells by application of controlled external electrical fields that transiently increase permeability of the ce… |
| IRE | Rubinsky · Technol Cancer Res Treat | 2007 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | This is a brief introduction to the emerging field of irreversible electroporation in medicine. Certain electrical fields when applied across a cell can have as a sole effect the permeabiliz… |
| ECT | Miklavcic et al · European Journal of Cancer Supplements | 2006 | Derleme | belirsiz | – | – | – | bleomisin | – | Bu yayında özet bulunmuyor. |
| ECT | Mir · European Journal of Cancer Supplements | 2006 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Electrochemotherapy is defined as the local potentiation, by means of permeabilizing electric pulses, of the antitumour activity of a non-permeant (or a low-permeant) anticancer drug possess… |
| Diğer EP | Rols · Biochim Biophys Acta | 2006 | Derleme | belirsiz | Reversible Membran Permeabilizasyonu | – | – | – | – | Electropermeabilization designates the use of short high-voltage pulses to overcome the barrier of the cell membrane. A position-dependent reversible local membrane permeabilization is induc… |
| Diğer EP | Prud'homme et al · Curr Gene Ther | 2006 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Nonviral gene transfer is markedly enhanced by the application of in vivo electroporation (also denoted electro-gene transfer or electrokinetic enhancement). This approach is safe and can be… |
| Diğer EP | Chen et al · Med Biol Eng Comput | 2006 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation, the transient increase in the permeability of cell membranes when exposed to a high electric field, is an established in vitro technique and is used to introduce DNA or othe… |
| Diğer EP | Phez et al · Biochim Biophys Acta | 2005 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | – | bleomisin · diğer yol | – | Electropermeabilization designates the use of electric pulses to overcome the barrier of the cell membrane. This physical method is used to transfer anticancer drugs or genes into living cel… |
| Diğer EP | Teissie et al · Biochim Biophys Acta | 2005 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Cell electropulsation is routinely used in cell Biology for protein, RNA or DNA transfer. Its clinical applications are under development for targeted drug delivery and gene therapy. Neverth… |
| ECT | Gothelf et al · Cancer Treat Rev | 2003 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 96 / 411 | – | bleomisin · hem intravenöz hem intratümöral | tam yanıt 9% (411 lezyon) | Over the last decade a new cancer treatment modality, electrochemotherapy, has emerged. By using short, intense electric pulses that surpass the capacitance of the cell membrane, permeabiliz… |
| ECT | Mir · Bioelectrochemistry | 2001 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | bleomisin · intratümöral | – | Cell electropermeabilization (also termed cell electroporation) is nowadays a routine technique used in biochemical and pharmacological studies for the in vitro introduction of nonpermeant m… |
| Diğer EP | Somiari et al · Mol Ther | 2000 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Efficient and safe methods for delivering exogenous genetic material into tissues must be developed before the clinical potential of gene therapy will be realized. Recently, in vivo electrop… |
| Diğer EP | Neumann et al · Bioelectrochemistry | 2000 | Derleme | belirsiz | Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Electrochemical microelectrode devices are among the great challenges for bioelectrochemistry, cell biology and recently also for biomedical research and new clinical electrotherapies. Two r… |
| ECT | Heller et al · Adv Drug Deliv Rev | 1999 | Derleme | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin · intravenöz | nesnel yanıt 80% (199 lezyon) | Electrochemotherapy is a novel treatment which consists of a combination of a chemotherapeutic agent and pulsed electric fields. This relatively new treatment modality relies on the physical… |
| ECT | Mir et al · Adv Drug Deliv Rev | 1999 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | – | – | Electrochemotherapy is a new therapeutic approach providing delivery into cell interiors of nonpermeant drugs with intracellular targets. It is based on the local application of short and in… |
| ECT | Neumann et al · Bioelectrochem Bioenerg | 1999 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electrooptical and conductometrical relaxation methods have given a new insight in the molecular mechanisms of the electroporative delivery of drug-like dyes and genes (DNA) to cells and tis… |
| Gen ET | Singh et al · Anticancer Drugs | 1999 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Tissue electroporation has been explored to enhance the local delivery of chemotherapueutic agents to solid tumors. The technique, known as electrochemotherapy (ECT), uses high-voltage pulse… |
| Diğer EP | Vanbever et al · Adv Drug Deliv Rev | 1999 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | This article reviews the studies on skin electroporation carried out in vivo in animals and emphasizes its potential therapeutic applications for transdermal and topical drug delivery. In ag… |
| Diğer EP | Jaroszeski et al · Adv Drug Deliv Rev | 1999 | Derleme | Hayvan (İn Vivo) | – | – | – | plazmid DNA · intratümöral | – | The physical phenomenon of electroporation has been successfully exploited in vitro for the delivery of genes, drugs, and other molecules with increasing frequency over the past two decades.… |
| ECT | Garner et al · IEEE Eng. Med. Biol. Mag. | 1996 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA) | – | – | bleomisin · intratümöral | – | Although electroporation in the past has mainly been used as a research tool, recent work has demonstrated its potential for clinical applications. Some of the areas explored include electro… |
| ECT | Mir et al · Gen Pharmacol | 1996 | Derleme | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin · intravenöz | – | 1. Bleomycin (BLM) is a cytotoxic drug currently used in anticancer chemotherapy. We present here a summary of the well established "old" knowledge concerning BLM structure, properties and a… |
| ECT | Dev et al · Cancer Treat Rev | 1994 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | bleomisin · intravenöz | tam yanıt 14 adet (34 lezyon) | A critical review is presented on a novel method of treating cancer by a combination of an electric field with chemotherapeutic agents. The work described here summarizes the current state o… |
| Diğer EP | Orlowski et al · Biochim Biophys Acta | 1993 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | – | – | Cell electropermeabilization is the transient permeabilization of the plasma membrane by means of short and intense electric pulses. Under optimized conditions, electropermeabilization is co… |
| Diğer EP | Arai et al · Gastro Hep Adv | 2026 | Hayvan Çalışması | Literatür Analizi | – | – | – | plazmid DNA | – | Gastro Hep Advances 2026;5:100916 RESEARCH LETTER ElectroporationInduced Gastric Cancer Models Through EpithelialSpecific Genetic Modifications G astric cancer remains a major global health … |
| Kalsiyum EP | Laursen et al · J Vis Exp | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – / 27 | OpField electrode | kalsiyum klorür · intratümöral | – | Bladder tumors constitute a substantial health challenge, yet advances in the treatment have been few. Electroporation is the use of brief electric pulses that permeabilize cell membranes wi… |
| Diğer EP | Vargas et al · Res Vet Sci | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | VET CP 125 | – | – | Introduction: The technique of electroporation is used to facilitate the selective delivery of chemotherapeutic drugs into neoplastic cells, a process known as electrochemotherapy. However, … |
| ECT | Bendix et al · Bioelectrochemistry | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM 2001 square wave electroporator | sisplatin | – | Dendritic cells (DCs) are central to the initiation of anti-tumour immunity, yet the direct effects of electrochemotherapy (ECT) on DC biology remain poorly defined. We investigated how vary… |
| Gen ET | Bozic et al · Biomed Pharmacother | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | ELECTRO Cell B10, ELECTRO Cell B10 electric pulse generator | plazmid DNA · intratümöral | tam yanıt 35% | This study investigated the antitumor efficacy of chemokine CCL5 gene therapy using gene electrotransfer (GET) in combination with radiotherapy (RT) in solid murine tumors CT26 and 4T1. In v… |
| Diğer EP | Grimm et al · Sci Rep | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | – | Coding nucleic acids (NAs) like DNA, mRNA or siRNA hold endless potential to engineer cells with respect to their genome and proteome. However, minimally invasive delivery of NAs across an i… |
| IRE | Cao et al · bioRxiv | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Sistemik / Abskopal İmmün Yanıt | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) has shown promise for treating pancreatic ductal adenocarcinoma (PDAC), but whether IRE can induce an abscopal effect is not established. We demonstrated t… |
| IRE | Liu · Commun Biol | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | steep pulse ablation instrument | – | – | Although irreversible electroporation (IRE) is an approved ablation therapy for liver cancer, the border of the IRE-induced inflammatory margin (IM) remains poorly defined, posing a challeng… |
| IRE | Qi et al · Adv Mater | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres, İrreversible Por Oluşumu ve Hücre Ölümü | – | ePulse | – | – | Cancer vaccines face limitations due to the immunosuppressive tumor microenvironment (TME) and the low immunogenicity of tumor antigens. Immunogenic cell death (ICD), triggered by mitochondr… |
| IRE | Sano et al · J Vasc Interv Radiol | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Purpose: To study the safety and reproducibility of high-voltage integrated nanosecond pulse irreversible electroporation (INSPIRE) administered through a single applicator and grounding pad… |
| IRE | Vista et al · Clin Cancer Res | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | Gene Pulser Xcell, ECM 630 | – | – | Purpose: One recurring challenge in cell therapy for solid tumors is poor tumor infiltration of adoptively transferred T cells. We previously showed that a subablative dose of tumor-targeted… |
| Diğer EP | Apollonio et al · Bioelectricity | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | bleomisin | – | Francesca Apollonio, PhD,1 James Lyng, PhD,2 Caterina Merla, PhD,3 Lluis Mir, PhD,4 and Emanuela Signori, PhD5 I t is a pleasure to introduce this special issue of Bioelectricity on Recent D… |
| ECT | Bogataj et al · Cancers (Basel) | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Background: Electrochemotherapy (ECT) enhances the intracellular delivery of chemotherapeutic agents, most notably bleomycin, through electroporation. Despite high response rates, tumor sens… |
| Diğer EP | Nafie et al · PLoS One | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | – | – | Aliya®Pulsed Electric Field (PEF) technology is an emerging strategy in the field of cancer treatment, offering a novel approach to ablation therapy that does not rely on thermal mechanisms.… |
| ECT | Radzevičiūtė-Valčiukė et al · Bioelectrochemistry | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin · intratümöral | – | Electrochemotherapy (ECT) is a cancer treatment approach that utilizes the application of electroporation (EP) with standard chemotherapeutic drugs, resulting in a locally enhanced chemother… |
| ECT | de Caro et al · J Control Release | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Kas Kasılması ve Anestezi Gereksinimi, İmmünojenik Hücre Ölümü (ICD) | – / 5 | H-FECT | bleomisin · intravenöz | nesnel yanıt 100% (5 hayvan) | Electroporation, a physical method that permeabilizes cell membranes, is increasingly used in cancer treatment. By enhancing the uptake of hydrophilic antitumor drugs, it boosts their cytoto… |
| Diğer EP | Almazloum et al · Med Eng Phys | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Electrical pulse generator | – | – | High-intensity, external electric fields (HIEF) have been used in research and therapy for abnormal generation/propagation of the cardiac electrical activity (e.g., defibrillation), and for … |
| Kalsiyum EP | Hu et al · Small | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Homeostazının Bozulması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – | – | kalsiyum klorür | – | Calcium overload is a promising anticancer treatment that kills tumor cells primarily by causing mitochondrial dysfunction in cells. However, calcium overload therapy is limited by inefficie… |
| Diğer EP | Szewczyk et al · Bioelectrochemistry | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | BTX 830 Electroporator | diğer · intratümöral | – | This study explores the combination of jasplakinolide with electroporation (JSP + EP), a method enhancing targeted molecule delivery. CHO-K1 (Chinese hamster ovarian), C2C12 (mouse myoblast)… |
| IRE | Aycock et al · IEEE Trans Biomed Eng | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | AngioDynamics bipolar applicator | – | – | Irreversible electroporation (IRE) is a minimally thermal tissue ablation modality used to treat solid tumors adjacent to critical structures. Widespread clinical adoption of IRE has been li… |
| IRE | Esparza · Ann Biomed Eng | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | EPULSUS 2.0 | – | – | High-frequency irreversible electroporation (H-FIRE) is a minimally invasive local ablation therapy known to activate the adaptive immune system and reprogram the tumor microenvironment. Its… |
| IRE | Flak et al · Cancer Treat Res Commun | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Bleomisin Hücre İçi Birikiminin Artması | – | NanoKnife | bleomisin · intravenöz | – | Background: Irreversible electroporation (IRE) is a novel anticancer ablative treatment, which has been proposed to enhance the efficacy of chemotherapy in the periphery of the ablated area … |
| IRE | Guo et al · IEEE Trans Biomed Eng | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Objective: Irreversible electroporation (IRE) is a non-thermal tissue ablation technique that induces tissue ablation by applying high-voltage pulses through electrodes. In this paper, an im… |
| IRE | Hirata et al · Cardiovasc Intervent Radiol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Sistemik / Abskopal İmmün Yanıt | – | BTX ECM830 | – | – | Purpose: This study aimed to compare systemic immune responses and metastatic effects induced by radiofrequency ablation (RFA) and irreversible electroporation (IRE) in murine tumor models. … |
| IRE | Korganbayev et al · Annu Int Conf IEEE Eng Med Biol Soc | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Irreversible electroporation (IRE) represents a minimally invasive and non-thermal method for tumor ablation, which induces cell death through short high-voltage pulses applied via two needl… |
| IRE | Li et al · Small | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | YTL-SGM01 | – | – | Irreversible electroporation (IRE) is a minimally invasive, non-thermal tumor ablation technique that induces nanoscale membrane perforation, leading to immunogenic cell death (ICD). However… |
| IRE | Ma et al · World J Gastrointest Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | – | – | – | – | Background: Irreversible electroporation (IRE) is a novel local tumor ablation approach with the potential to activate the host's immune system. However, this approach is insufficient to pre… |
| IRE | Murphy · Cells | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Kan-Beyin Bariyeri Geçirgenliğinin Artması, Reversible Membran Permeabilizasyonu | – | – | – | – | High-frequency irreversible electroporation (H-FIRE) is a nonthermal tumor ablation technique that disrupts the blood-brain barrier (BBB) in a focal and reversible manner. However, the mecha… |
| IRE | Nafie · Front Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | Aliya, BTX ECM830 | – | genel sağkalım 36 gün (10 hayvan) | Intoduction: Non-thermal ablation, including irreversible electroporation (IRE) and Aliya®, an advanced biphasic pulsed electric field (aPEF) technology, have emerged as effective tumor abla… |
| IRE | Wang et al · Gene | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | genel sağkalım 19 gün (8 hayvan) | Previous studies have demonstrated that synergistic bipolar irreversible electroporation (SBIRE) is a promising non-thermal tumor ablation technique that effectively targets tumors without c… |
| Diğer EP | Fesmire et al · IEEE Trans Biomed Eng | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması, Sinir ve Damar Yapılarının Korunması | – / 25 | custom pulse generator | – | tam yanıt 93% | Objective: To study the safety and efficacy of algorithmically controlled electroporation (ACE) against spontaneous equine melanoma. Methods: A custom temperature sensing coaxial electrode w… |
| ECT | Malyško-Ptašinskė et al · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – | – | sisplatin · intratümöral | – | Electroporation-based procedures employing nanosecond bipolar pulses are commonly linked to an undesirable phenomenon known as the cancelation effect. The cancellation effect arises when the… |
| Belirlenmedi | Universitat des Saarlandes · – | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | SENNEX | bleomisin · intravenöz | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Ye et al · Stem Cell Res Ther | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Sisplatin Hücre İçi Birikiminin Artması | – | Gene Pulser Xcell | – | – | Background: Cisplatin (DDP) is an efficacious and widely applied chemotherapeutic drug for cervical cancer patients who are diagnosed as metastatic and inoperable, or desiring fertility pres… |
| Gen ET | Lampreht · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · diğer yol | – | Gene electrotransfer (GET) of plasmids encoding interleukin 12 (IL-12) has already been used for the treatment of various types of tumors in human oncology and as an adjuvant in DNA vaccines… |
| Diğer EP | Maji · Pharmaceutics | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Ekstraselüler Matriks ve Doku İskeletinin Korunması | – | RenBio custom-built generator, in-house-developed needle-based electroporator, rabbit electroporator device | plazmid DNA · diğer yol | – | Electroporation (EP) stands out as a promising non-viral plasmid delivery strategy, although achieving optimal transfection efficiency in vivo remains a challenge. A noteworthy advancement i… |
| Diğer EP | Shi et al · Cancer Immunol Immunother | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · intratümöral | – | Background: Tumor-reactive T cells play a crucial role in anti-tumor responses, but T cells induced by DNA vaccination are time-consuming processes and exhibit limited anti-tumor efficacy. T… |
| Diğer EP | Lorenzen et al · J Vis Exp | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi | – | – | diğer | – | Porous substrate electroporation (PSEP) is an emerging method of electroporation that provides high throughput and consistent delivery. Like many other types of intracellular delivery, PSEP … |
| IRE | Jeon · Cancers (Basel) | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | BTX Gemini X2 | – | – | The regulation of apoptosis is the primary goal of ablation therapy. Irreversible electroporation (IRE) is a promising non-thermal tissue ablation-based therapy that induces apoptosis by man… |
| IRE | Jeon et al · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | diğer 3 cm³ | Irreversible electroporation (IRE) is a prominent non-thermal ablation method widely employed in clinical settings for the focal ablation therapy of solid tumors. Utilizing high-voltage, sho… |
| IRE | Rajagopalan et al · Bioelectrochemistry | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | – | BTX ECM830, NanoKnife | – | – | Membrane permeabilization and thermal injury are the major cause of cell death during irreversible electroporation (IRE) performed using high electric field strength (EFS) and small number o… |
| IRE | Zeng et al · Sci Rep | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX Genetronics, BTX Genetronics needle electrodes | – | tam yanıt 58.7% (4 hayvan) | To evaluate the safety and efficacy of combining EW-7197 with irreversible electroporation (IRE) for improving wound healing, 16 male Sprague-Dawley rats were randomly divided into four grou… |
| ECT | Guedert et al · Bioelectrochemistry | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Termal Etki ve Joule Isınması | – | – | – | – | Electroporation alters cell membrane structure and tissue electrical properties by short and intense pulsed electric fields (PEF). Static mathematical models are often used to explain the ch… |
| Diğer EP | Olaiz et al · Cells | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | BTX ECM830 | diğer · intravenöz | – | Boron neutron capture therapy (BNCT) combines preferential tumor uptake of 10 B compounds and neutron irradiation. Electroporation induces an increase in the permeability of the cell membran… |
| ECT | Radzevičiūtė-Valčiukė et al · Pharmaceuticals (Basel) | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | – | – | kalsiyum klorür · intratümöral | – | Calcium electroporation (CaEP) is an innovative approach to treating cancer, involving the internalization of supraphysiological amounts of calcium through electroporation, which leads to ce… |
| ECT | Raeisi et al · J Shahrekord Univ Med Sci | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – / 50 | ECT-SBDC | sisplatin · intratümöral | kısmi yanıt 61.2 oran (10 hayvan) | Background and aims: Electroporation demonstrated certain modulable actions on tumoral cell membrane permeability to increase the intracellular bioavailability of chemotherapeutic drugs. The… |
| ECT | Kesar et al · Vaccines (Basel) | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İmmünojenik Hücre Ölümü (ICD), Bleomisin Hücre İçi Birikiminin Artması | – | Jouan GHT beta | bleomisin · intratümöral | – | Electrochemotherapy (ECT) is a clinically acknowledged method that combines the use of anticancer drugs and electrical pulses. Electrochemotherapy with bleomycin (BLM) can induce immunogenic… |
| Gen ET | Komel · Int J Mol Sci | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | ELECTRO cell B10 | plazmid DNA · intratümöral | – | Gene immunotherapy has become an important approach in the treatment of cancer. One example is the introduction of genes encoding immunostimulatory cytokines, such as interleukin 2 and inter… |
| IRE | Jacobs et al · Comput Biol Med | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması, Darbe Parametrelerinin Optimizasyonu | – | VoltMed custom generator, NanoKnife | – | – | The nonthermal mechanism for irreversible electroporation has been paramount for treating tumors and cardiac tissue in anatomically sensitive areas, where there is concern about damage to ne… |
| IRE | Peng et al · APL Bioeng | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | diğer · intratümöral | tümör hacmi değişimi 4.94 cm³ (5 hayvan) | Precise control of cargo release is essential but still a great challenge for any drug delivery system. Irreversible electroporation (IRE), utilizing short high-voltage pulsed electric field… |
| IRE | Razakamanantsoa et al · Bioelectrochemistry | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) has been reported to variably cause apoptosis, necrosis, oncosis or pyroptosis. Intracellular ATP is a key substrate for apoptosis which is rapidly deplete… |
| ECT | Novickij et al · IEEE Trans Biomed Eng | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin · intratümöral | – | Objective: this work focuses on bleomycin electrochemotherapy using new modality of high repetition frequency unipolar nanosecond pulses. Methods: As a tumor model, Lewis lung carcinoma (LLC… |
| ECT | Radzevičiūtė et al · Bioelectrochemistry | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | VilniusTECH | bleomisin | hücre canlılığı 93.1% | Electroporation is a pulsed electric field (PEF) induced phenomenon, which effectiveness varies dependent on pulse parameters. This work focuses on nano-electrochemotherapy with bleomycin an… |
| ECT | Balevičiūtė et al · Cancers (Basel) | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | square-wave pulse generator developed in VilniusTECH Univers | bleomisin · intratümöral | – | In this work, a time-dependent and time-independent study on bleomycin-based high-frequency nsECT (3.5 kV/cm × 200 pulses) for the elimination of LLC1 tumours in C57BL/6J mice is performed. … |
| Diğer EP | Paffenholz et al · Proc Natl Acad Sci U S A | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | NEPA21 | – · intratümöral | tümör hacmi değişimi 40 gün (5 hayvan) | High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to the limited effectiveness of existing chemo- and immunotherapies. To elucidate mechanisms mediating sensi… |
| Kalsiyum EP | Ruzgys · Cancers (Basel) | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Sistemik / Abskopal İmmün Yanıt, Bleomisin Hücre İçi Birikiminin Artması | – / 2 | BTX T820 electroporator | – | – | Electroporation-based antitumor therapies, including bleomycin electrotransfer, calcium electroporation, and irreversible electroporation, are very effective on directly treated tumors, but … |
| Diğer EP | Maciulevičius et al · Bioelectrochemistry | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | electroporator developed at Vytautas Magnus University in co | bleomisin · intratümöral | tam yanıt 50% | Targeted and controlled techniques of intratumoral delivery of chemotherapeutic agents are under extensive development, since they diminish detrimental side-effects of conventional anticance… |
| IRE | Kim · Sci Rep | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | EPO-S1 | – | – | As a non-thermal ablation method, irreversible electroporation (IRE) has been widely investigated in the treatment of prostate cancer. However, no consensus has been achieved on the optimal … |
| Diğer EP | Ghorbel et al · Bioelectrochemistry | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | bleomisin · diğer yol | – | The use of conductive nanoparticles (NPs) was previously proposed as a way to locally amplify the electric field (EF) intensity at the cell membrane to enhance cell electroporation. To achie… |
| ECT | Navickaitė et al · Bioelectrochemistry | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Homeostazının Bozulması | – | – | kalsiyum klorür · diğer yol | – | The combination of Ca 2+ ions and electroporation has gained attention as potential alternative to electrochemotherapy. Ca 2+ is an important component of the cell membrane repair system and… |
| IRE | Ruzgys · Molecules | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | BTX T820, BTX T820 electroporator | bleomisin | hücre canlılığı 2.8% | One of current applications of electroporation is electrochemotherapy and electroablation for local cancer treatment. Both of these electroporation modalities share some similarities with ra… |
| Gen ET | Kamensek et al · Bioelectrochemistry | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | Electro Cell B10, Electro Cell B10 electric pulse generator | plazmid DNA · intratümöral | lokal kontrol 16 gün (9 hayvan) | In situ vaccination is a promising immunotherapeutic approach, where various local ablative therapies are used to induce an immune response against tumor antigens that are released from the … |
| Gen ET | Ursic et al · J Control Release | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin · intratümöral | tam yanıt 38% (8 hayvan) | Electrochemotherapy (ECT) exhibits high therapeutic effectiveness in the clinic, achieving up to 80% local tumor control but without a systemic (abscopal) effect. Therefore, we designed a co… |
| ECT | Vižintin et al · Bioelectrochemistry | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | laboratory prototype pulse generator, Cliniporator VITAE, CellFX System | bleomisin | hücre canlılığı 40% | Nanosecond electric pulses have several potential advantages in electroporation-based procedures over the conventional micro- and millisecond pulses including low level of heating, reduced e… |
| Diğer EP | Wu et al · Proc Natl Acad Sci U S A | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | plazmid DNA | – | Herein, we studied localized electroporation and gene transfection of mammalian cells using a metallodielectric hybrid micromotor that is magnetically and electrically powered. Much like nan… |
| ECT | Cvetković et al · JSSCM | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – / 1 | – | – | tam yanıt 1 adet (1 lezyon) | This is a feasibility study for the application of a novel concept of single-needle device for localized chemotherapy. Systemic chemotherapy has numerous and severe side effects. To conduct … |
| Gen ET | Jiang et al · IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | – | – | – | Nonthermal atmospheric pressure plasmas produce reactive plasma species including charged particles and reactive oxygen nitrogen species, which are known to induce oxidative stress in living… |
| IRE | Babikr et al · Cell Mol Immunol | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) is a new cancer ablation technology, but methods to improve IRE-induced therapeutic immunity are only beginning to be investigated. We developed a mouse mo… |
| IRE | Beitel-White et al · IEEE Trans Biomed Eng | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Objective: Tissue electroporation is achieved by applying a series of electric pulses to destabilize cell membranes within the target tissue. The treatment volume is dictated by the electric… |
| IRE | Li et al · Surg Endosc | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 32 | BTX Gemini X2 | – | ablasyon hacmi 93.75% (32 lezyon) | Background: The aim of this study was to evaluate the feasibility, safety, and efficacy of magnetic anchoring and guidance-assisted endoscopic irreversible electroporation (MAG-IRE) for gast… |
| IRE | Lim · Sci Rep | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | Bi-E-EPO1 bipolar electrode, EPO1 IRE equipment | – | – | The exposure of the prostate to high electric field strength during irreversible electroporation (IRE) has been extensively investigated. Multiple monopolar electrodes, however, have risks o… |
| IRE | Zhang et al · Int J Hyperthermia | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Kas Kasılması ve Anestezi Gereksinimi | – | custom-made H-FIRE pulse generator, Genetrode 508 | – | ablasyon hacmi 90.1 mm (3 örnek) | Purpose: To examine the ablation zone, muscle contractions, and temperature increases in both rabbit liver and kidney models in vivo for a custom-made high-frequency irreversible electropora… |
| ECT | Azan et al · Sci Rep | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | Cliniporator | – | – | The permeabilization of the live cells membrane by the delivery of electric pulses has fundamental interest in medicine, in particular in tumors treatment by electrochemotherapy. Since under… |
| Diğer EP | Bo et al · Int J Mol Sci | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Reversible Membran Permeabilizasyonu | – | custom-built in house at ODU, custom built at Vilnius Gediminas Technical University, custom-built MOSFET-based generator, custom-built generator | – | – | The principal bioeffect of the nanosecond pulsed electric field (nsPEF) is a lasting cell membrane permeabilization, which is often attributed to the formation of nanometer-sized pores. Such… |
| Gen ET | Dermol-Černe et al · Sci Rep | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – | laboratory prototype, Electro cell B10 electroporator, Intracell TSS20 Ovodyne generator, BetaTech | – | – | In gene electrotransfer and cardiac ablation with irreversible electroporation, treated muscle cells are typically of elongated shape and their orientation may vary. Orientation of cells in … |
| ECT | García-Sánchez et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | This study presents electrical measurements (both conductivity during the pulses and impedance spectroscopy before and after) performed in liver tissue of mice during electroporation with cl… |
| Diğer EP | Kim et al · Technol Cancer Res Treat | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Reversible Membran Permeabilizasyonu | – | PL-3003D, EpoTM | – | – | Tissue electrolysis is an alternative modality that uses a low intensity direct electric current passing through at least 2 electrodes within the tissue and resulting electrochemical product… |
| ECT | Li et al · ACS Appl Mater Interfaces | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | – | diğer · diğer yol | – | Cancer residues around the surgical site remain a significant cause of treatment failure with cancer recurrence. To prevent cancer recurrence and simultaneously repair surgery-caused defects… |
| ECT | Mansourian et al · Electromagn Biol Med | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Persianporator | bleomisin · intratümöral | – | Electrochemotherapy (ECT) is a new and promising treatment strategy for cancer treatment. The aim of this work is to investigate the effect of 900 MHz radiofrequency electromagnetic fields (… |
| ECT | Mansourian et al · Electromagn Biol Med | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | bleomisin · intratümöral | – | Electrochemotherapy (ECT), the combination of electric pulses (EPs) and an anticancer drug, is a type of cancer treatment method. We investigated the effect of 217-Hz magnetic fields (MFs) s… |
| Diğer EP | Miklavcic et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Reversible Membran Permeabilizasyonu | – | IGEA HVP-VG | – | hücre canlılığı 100% | Pulsed electric fields (PEFs) can be used to transiently increase cell membrane permeability in procedures ranging from gene therapy to tumor eradication. Although very efficient, PEF-based … |
| Kalsiyum EP | Novickij · Sci Rep | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Doku İletkenliği ve Empedans Değişimi | – | 3 kV, 100 ns–1 ms square wave high voltage pulse generator, PPG-20 generator | kalsiyum klorür | – | In the present study, we report the effects of extracellular medium conductivity on cell response in the context of sub-microsecond range (100 ns-900 ns) electroporation, calcium electropora… |
| ECT | Novickij et al · Molecules | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Doku İletkenliği ve Empedans Değişimi | – | – | diğer · intravenöz | – | Pulsed electric field (PEF) is frequently used for intertumoral drug delivery resulting in a well-known anticancer treatment-electrochemotherapy. However, electrochemotherapy is associated w… |
| IRE | Polajžer et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | hücre canlılığı 50% | It was recently suggested that applying high-frequency short biphasic pulses (HF-IRE) reduces pain and muscle contractions in electrochemotherapy and irreversible ablation treatments; howeve… |
| ECT | Sarnago et al · IEEE Access | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Custom-built GaN multilevel inverter | bleomisin · intratümöral | – | Biomedical applications often require high-performance power supplies for diagnosis and treatment systems. In particular, modern electroporation techniques for cancer treatment require high-… |
| Diğer EP | Zhao et al · Front Bioeng Biotechnol | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Pulsed electric field treatment modalities typically utilize multiple pulses to permeabilize biological tissue. This electroporation process induces conductivity changes in the tissue, which… |
| IRE | Go et al · Cancers (Basel) | 2020 | Hayvan Çalışması | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, İmmünojenik Hücre Ölümü (ICD) | – | BTX Harvard Apparatus, BTX Harvard Apparatus electroporation system | – | – | Recently, cancer immunotherapy has received attention as a viable solution for the treatment of refractory tumors. However, it still has clinical limitations in its treatment efficacy due to… |
| IRE | Merola et al · Biology (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | Cliniporator VITAE | – | – | Objective: To test a new bipolar electrode for electroporation consisting of a single minimally invasive needle. Methods: A theoretical study was performed by using Comsol Multiphysics ® sof… |
| IRE | Vižintin et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | To achieve high efficiency of electroporation and to minimize unwanted side effects, the electric field parameters must be optimized. Recently, it was suggested that biphasic high-frequency … |
| IRE | Wasson et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | kalsiyum klorür | – | High-frequency irreversible electroporation (H-FIRE) is an emerging electroporation-based therapy used to ablate cancerous tissue. Treatment consists of delivering short, bipolar pulses (1-1… |
| IRE | Wood et al · J Surg Res | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – | BTX 830 ECM electroporator | – | – | Background: Nonthermal irreversible electroporation (NTIRE) has been shown to ablate the small intestinal epithelium while maintaining submucosal and muscularis propriae integrity. NTIRE is … |
| Diğer EP | Dettin et al · Cells | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Ekstraselüler Matriks ve Doku İskeletinin Korunması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | EPS-02 | – | – | Tumor electroporation (EP) refers to the permeabilization of the cell membrane by means of short electric pulses thus allowing the potentiation of chemotherapeutic drugs. Standard plate adhe… |
| ECT | Garabalino et al · Radiat Environ Biophys | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – / 56 | BTX ECM830 | – | – | Boron neutron capture therapy (BNCT) is a promising cancer binary therapy modality that utilizes the nuclear capture reaction of thermal neutrons by boron-10 resulting in a localized release… |
| Diğer EP | Ghorbel et al · Nanotechnology | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator | bleomisin · intratümöral | hücre canlılığı 80% | Conducive nanoparticles (NPs) were proposed to locally amplify the external electric field (EF) intensity at the cell surface to improve cell electroporation. To better understand the physic… |
| Diğer EP | Lorenzo et al · Cancers (Basel) | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Kan-Beyin Bariyeri Geçirgenliğinin Artması, Elektrik Alan Dağılımı ve Modellemesi | – | EPULSUS-FBM1-5 | – | – | Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due to protection from the blood-brain barrier (BBB). Electroporation-based thera… |
| Diğer EP | Mutsenko et al · Cryobiology | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | – | BTX Gemini 2 Electroporation System, BetaTech | diğer | hücre canlılığı 76% | Cryopreservation is the universal technology used to enable long-term storage and continuous availability of cell stocks and tissues for regenerative medicine demands. The main components of… |
| ECT | Pedersoli et al · Eur Radiol | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | ECM 630 Electroporation System | diğer · intratümöral | – | Objectives: We conducted an in vivo trial to investigate the safety and efficacy of a newly developed system for the application of a combined therapy consisting of irreversible electroporat… |
| ECT | Pintarelli et al · Med Eng Phys | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Bleomisin Hücre İçi Birikiminin Artması | – / 1 | Vet CP 125, Vet CP 125 electroporator | bleomisin · intravenöz | tümör hacmi değişimi 0 adet (1 hasta) | Electrochemotherapy (ECT) exploits the phenomenon of electroporation, which is the increase of cell permeability through the application of an electrical field. This technique is applied in … |
| ECT | Donnelly et al · J Aquat Anim Health | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | – / 2 | Vet-ePorator, Electrovet EZ | bleomisin · intratümöral | tam yanıt 100% (2 lezyon) | Fibropapillomatosis of sea turtles is traditionally treated with surgical debulking techniques that are often associated with prolonged healing and tumor recurrence. Electrochemotherapy was … |
| Diğer EP | Ruzgys et al · Bioelectrochemistry | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Electroporation is a widely-used methodology for permeabilization of cells using pulsed electric field (PEF). In this paper, we compare the electroporation efficiency in terms of molecular t… |
| IRE | López-Alonso et al · Sci Rep | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | tam yanıt 100% (6 hayvan) | Irreversible electroporation (IRE) has gained attention as a new non-thermal therapy for ablation with important benefits in terms of homogeneous treatment and fast recovery. In this study, … |
| Kalsiyum EP | Novickij · Cancers (Basel) | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – | square wave pulse generator developed in Vilnius Gediminas T | kalsiyum klorür · intratümöral | – | In this work, we have investigated the feasibility of sub-microsecond range irreversible electroporation (IRE) with and without calcium electroporation in vivo. As a model, BALB/C mice were … |
| IRE | Ringel-Scaia et al · EBioMedicine | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | EPULSUS-FBM1-5 | – | tam yanıt 30% | Background: Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible electroporation (H-FIRE… |
| Diğer EP | Bhonsle et al · IEEE Trans Biomed Eng | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Objective: The use of high-voltage, high-frequency bipolar pulses (HFBPs) is an emerging electroporation-based therapy for the treatment of solid tumors. In this study, we quantify the exten… |
| ECT | Dermol-Černe et al · J Control Release | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – | BetaTech | sisplatin | – | In electrochemotherapy two conditions have to be met to be successful - the electric field of sufficient amplitude and sufficient uptake of chemotherapeutics in the tumor. Current treatment … |
| Diğer EP | García-Sánchez et al · Bioelectrochemistry | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin | – | The effects of pyroelectricity on cell membrane permeability had never been explored. Pyroelectricity consists in the generation of an electric field in the surface of some materials when a … |
| Diğer EP | García-Sánchez et al · Biochim Biophys Acta Biomembr | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Doku İletkenliği ve Empedans Değişimi | – | – | – | – | The permeabilization of biological membranes by electric fields, known as electroporation, has been traditionally performed with square electric pulses. These signals distribute the energy a… |
| Diğer EP | Huang et al · Theranostics | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Electro Square Porator ECM 830, Tweezertrodes, FIEA | plazmid DNA · topikal | – | Rationale: Delivery of nucleic acid molecules into skin remains a main obstacle for various types of gene therapy or vaccine applications. Here we propose a novel electroporation approach vi… |
| Diğer EP | Markelc et al · J Control Release | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Vasküler Kilit (Vascular Lock) Etkisi | – | Electrocell S20 | – | – | Delivery of electric field pulses, i.e. electroporation (EP), to tissues has been shown to have a blood flow modifying effect. Indeed, the diameter of blood vessels exposed to EP is immediat… |
| Kalsiyum EP | Staresinic et al · Sci Rep | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | – | ELECTRO cell B10 HVLV | kalsiyum klorür · intratümöral | – | Calcium electroporation (CaEP) is a novel anti-tumour treatment that induces cell death by internalization of large quantities of calcium. The anti-tumour effectiveness of CaEP has been demo… |
| Diğer EP | Brown et al · Bioelectrochemistry | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | – | – | plazmid DNA · intratümöral | – | Intratumoral electroporation of plasmid DNA encoding the proinflammatory cytokine interleukin 12 promotes innate and adaptive immune responses correlating with anti-tumor effects. Clinical e… |
| Gen ET | Burkart et al · Gene Ther | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | MedPulser, BTX ECM830, GENESIS low voltage generator | plazmid DNA · intratümöral | – | The use of immunomodulatory cytokines has been shown effective in regressing a wide range of tumors. However, systemic delivery of recombinant cytokines results in serious, potentially life-… |
| Diğer EP | Mukhopadhyay et al · Gene Ther | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Sistemik / Abskopal İmmün Yanıt | – | BTX ECM830, GENESIS square wave generator | plazmid DNA · intratümöral | – | Intratumoral electroporation-mediated IL-12 gene therapy (IT-pIL12/EP) has been shown to be safe and effective in clinical trials, demonstrating systemic antitumor effects with local deliver… |
| ECT | Tremble et al · Cancer Lett | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İmmünojenik Hücre Ölümü (ICD) | – | Cliniporator | sisplatin · intratümöral | genel sağkalım 50% (6 hayvan) | Electrochemotherapy is an evolving therapy which has recently been shown to induce an immunogenic form of cell death. It is hypothesized that the immunogenic cell death induced by electroche… |
| Diğer EP | Dermol-Cerne et al · IEEE Trans Biomed Eng | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | – | – | Current models of tissue electroporation either describe tissue with its bulk properties or include cell level properties, but model only a few cells of simple shapes in low-volume fractions… |
| Belirlenmedi | Mi et al · Technol Cancer Res Treat | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | – | – | – | – | We studied the influence of various parameters of high-frequency nanosecond pulse bursts on the strength of rabbit muscle contractions. Ten unipolar high-frequency pulse bursts with various … |
| IRE | O’Brien et al · Int J Hyperthermia | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 60 | – | – | – | Purpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and tempera… |
| IRE | Sano et al · J Vasc Interv Radiol | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Kas Kasılması ve Anestezi Gereksinimi | – | custom pulse generators | – | – | Purpose: To compare the intensity of muscle contractions in irreversible electroporation (IRE) treatments when traditional IRE and high-frequency IRE (H-FIRE) waveforms are used in combinati… |
| IRE | Tian et al · Drug Deliv | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) is an emerging minimally invasive tumor ablation technique that delivers short pulses of strong electric fields and kills cancer cells by disrupting their … |
| Diğer EP | Caprettini et al · Sci Rep | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Electroporation of in-vitro cultured cells is widely used in biological and medical areas to deliver molecules of interest inside cells. Since very high electric fields are required to elect… |
| Diğer EP | Ciobanu et al · J Membr Biol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | PS10 CNRS electropulser, PS10 CNRS electropulser (Jouan) | kalsiyum klorür | – | Electric pulses, when applied to a cell suspension, induce a reversible permeabilization of the plasma membrane. This permeabilized state is a long-lived process (minutes). The biophysical m… |
| Diğer EP | Hanna et al · Sci Rep | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Nanosaniye Darbeli Elektrik Alan (nsPEF) | – | – | kalsiyum klorür | – | Microsecond pulsed electric fields (μsPEF) permeabilize the plasma membrane (PM) and are widely used in research, medicine and biotechnology. For internal membranes permeabilization, nanosec… |
| Diğer EP | Zhang et al · Am J Physiol Lung Cell Mol Physiol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Neon Transfection System | – | – | Exosomes are nanovesicles secreted by cells and contain various molecules including protein, lipid, and DNA/RNA. They are crucial mediators of the intercellular communication and serve as pr… |
| Kalsiyum EP | Frandsen et al · Cancer Res | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Nekroz ve Nekroptoz | – | Cliniporator | kalsiyum klorür · intratümöral | – | Calcium electroporation may offer a simple general tool for anticancer therapy. Transient permeabilization of cancer cell membranes created by applying short, high-voltage pulses in tumors e… |
| Gen ET | Kamensek et al · Plasmid | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | generator of electric pulses | plazmid DNA | – | Electrotransfer mediated delivery of interleukin-12 (IL-12) gene, encoded on a plasmid vector, has already been demonstrated to have a potent antitumor efficacy and great potential for clini… |
| Gen ET | Kos et al · Bioelectrochemistry | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | – | Cliniporator, MEA (multi-electrode array) | plazmid DNA · diğer yol | – | Skin is an attractive target for gene electrotransfer due to its easy accessibility and its interesting immune properties. Since electrodes are often invasive and frequently induce discomfor… |
| Diğer EP | Liu et al · Protein Cell | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | BTX ECM830 | diğer | – | The generation of T cells with maximal anti-tumor activities will significantly impact the field of T-cell-based adoptive immunotherapy. In this report, we found that OKT3/IL-2-stimulated T … |
| Diğer EP | Sales et al · Vaccine | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | NEPA21, NEPA21 electroporator, CUY560-5-0.5 electrode | plazmid DNA · intravenöz | – | In vivo electroporation (EP) has reignited the clinical interest on DNA vaccines as immunotherapeutic approaches to control different types of cancer. EP has been associated with increased i… |
| IRE | Wang · Oncol Lett | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | electric pulses therapeutic system, Gene Pulser | plazmid DNA · intratümöral | – | Irreversible electroporation (IRE) is a physical, non-thermal cancer therapy, which leads to cell death via permanent membrane permeability. This differs from reversible electroporation (RE)… |
| IRE | Chai et al · Biomed Microdevices | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | The aim of this study was to evaluate the effects of irreversible electroporation (IRE) on the eradication of rabbit VX2 cervical tumors. A VX2 cervical cancer model was first made in 20 New… |
| IRE | Kranjc · Sci Rep | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | Cliniporator VITAE | – | – | Irreversible electroporation (IRE) is gaining importance in routine clinical practice for nonthermal ablation of solid tumors. For its success, it is extremely important that the coverage an… |
| IRE | Li et al · Exp Ther Med | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | The aim of the present study was to evaluate the effects of irreversible electroporation (IRE) on the stomach wall following the direct application of IRE onto the organ surface. IRE ablatio… |
| IRE | Srimathveeravalli et al · J Vasc Interv Radiol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | catheter-mounted IRE electrode | – | – | Purpose: To evaluate the effect of catheter-directed irreversible electroporation (IRE) on the integrity, patency, and function of the normal porcine ureter. Materials and methods: A cathete… |
| IRE | Yao · Sci Rep | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | custom pulse generator | – | – | Irreversible electroporation (IRE) uses ~100 μs pulsed electric fields to disrupt cell membranes for solid tumor ablation. Although IRE has achieved exciting preliminary clinical results, im… |
| Diğer EP | Dermol et al · PLoS One | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | βtech electroporator | – | – | Electroporation-induced cell sensitization was described as the occurrence of a delayed hypersensitivity to electric pulses caused by pretreating cells with electric pulses. It was achieved … |
| ECT | Maglietti et al · Radiol Oncol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | BTX ECM830 | bleomisin · hem intravenöz hem intratümöral | nesnel yanıt 91% (11 hasta) | Background: Electrochemotherapy (ECT), a medical treatment widely used in human patients for tumor treatment, increases bleomycin toxicity by 1000 fold in the treated area with an objective … |
| Diğer EP | Silve et al · Sci Rep | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | pulse-forming line generator | bleomisin | – | The impact of external medium conductivity on the efficiency of the reversible permeabilisation caused by pulsed electric fields was investigated. Pulses of 12 ns, 102 ns or 100 μs were inve… |
| Diğer EP | Sweeney et al · Biochim Biophys Acta | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | High-frequency bipolar electric pulses have been shown to mitigate undesirable muscle contraction during irreversible electroporation (IRE) therapy. Here, we evaluate the potential applicabi… |
| Gen ET | Stimac et al · Cancer Gene Ther | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Apoptoz İndüksiyonu | – | – | plazmid DNA · intratümöral | – | Gene electrotransfer of plasmid encoding shRNA against endoglin exerts antitumor efficacy, predominantly by vascular targeted effect. As vascular targeting therapies can promote radiosensiti… |
| Diğer EP | Znidar et al · Mol Ther Nucleic Acids | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Nekroz ve Nekroptoz, Gen Elektrotransferi (Plazmid DNA) | – | Electro Cell B10, GT-01, T820 Electrosquare porator | plazmid DNA · intratümöral | – | In several preclinical tumor models, antitumor effects occur after intratumoral electroporation, also known as electrotransfer, of plasmid DNA devoid of a therapeutic gene. In mouse melanoma… |
| IRE | Wandel et al · J Vasc Interv Radiol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Purpose: To optimize single-insertion bipolar irreversible electroporation (IRE) by characterizing effects of electric parameters and controlling tissue electric properties in a porcine mode… |
| IRE | Lin et al · Ultrasound Med Biol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | The objective of this study was to describe the performance of ultrasound (US) and contrast-enhanced ultrasound (CEUS) within 2 h after irreversible electroporation (IRE) ablation of porcine… |
| Diğer EP | Demiryurek et al · Biochim Biophys Acta | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | – | diğer · diğer yol | – | Electroporation is of interest for many drug-delivery and gene-therapy applications. Prior studies have shown that a two-pulse-electroporation protocol consisting of a short-duration, high-v… |
| Gen ET | Dolinsek et al · Curr Gene Ther | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | – | GT-1 electroporator, ELECTRO cell B10 HVLV | plazmid DNA · intratümöral | – | New targets and therapeutic approaches for vascular targeted strategies in oncology are continuously explored. Endoglin, a co-receptor of TGF-β, is a known target, however, its silencing wit… |
| Diğer EP | Mahmood et al · Acta Oncol | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | – | – | Background: Tissue permeabilization by electroporation (EP) is a promising technique to treat certain cancers. Non-invasive methods for verification of induced permeabilization are important… |
| Diğer EP | Semenov et al · Biochim Biophys Acta | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | FPG 20-1NM, Grass S88 Stimulator, FPG 20-1NM pulse generator | – | – | Ca2+ activation and membrane electroporation by 10-ns and 4-ms electric pulses (nsEP and msEP) were compared in rat embryonic cardiomyocytes. The lowest electric field which triggered Ca2+ t… |
| Gen ET | Trainito et al · Electrophoresis | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | The electric field is commonly used in microdevices to handle, treat, or monitor living cells for various biological or biomedical applications (cells electrofusion, gene electrotransfer, dr… |
| Diğer EP | Wegner et al · Biophys J | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Treatment of biological material by pulsed electric fields is a versatile technique in biotechnology and biomedicine used, for example, in delivering DNA into cells (transfection), ablation … |
| Diğer EP | Zorec et al · Int J Pharm | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Green Skin Pore | diğer · topikal | – | In our present study we focus on two physical enhancement methods for transdermal drug delivery: ultrasound and electric pulses either alone or in combination. Great emphasis has been given … |
| Diğer EP | Amante et al · Hum Gene Ther Methods | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | CELLECTRA-3P | – | – | The CELLECTRA-3P dermal electroporation device (Inovio Pharmaceuticals, Plymouth Meeting, PA) has been evaluated in the clinic and shown to enhance the delivery of an influenza DNA vaccine. … |
| Diğer EP | Brolin et al · Mol Ther Nucleic Acids | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Cliniporator, IGEA plate electrodes | – · intratümöral | – | Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting f… |
| Gen ET | Heller et al · Adv Genet | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | 24 | – | plazmid DNA · intratümöral | genel sağkalım 10 adet (24 hasta) | Plasmid or non-viral gene therapy offers an alternative to classic viral gene delivery that negates the need for a biological vector. In this case, delivery is enhanced by a variety of appro… |
| Diğer EP | Lamolinara et al · J Immunol Res | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Cliniporator | – · intratümöral | tümör hacmi değişimi 0 cm³ (12 hasta) | Skin represents an attractive target for DNA vaccine delivery because of its natural richness in APCs, whose targeting may potentiate the effect of vaccination. Nevertheless, intramuscular e… |
| Gen ET | Markelc et al · Bioelectrochemistry | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | GT-1 electropulsator | plazmid DNA · diğer yol | – | Application of electric pulses (electroporation/electropermeabilization) is an effective method for gene transfer (i.e. gene electrotransfer (GET)) in vitro and in vivo. Currently, the mecha… |
| Gen ET | Pavlin et al · Sci Rep | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | prototype electric pulse generator | plazmid DNA · diğer yol | – | Gene electrotransfer is a promising non-viral method of gene delivery. In our in vitro study we addressed open questions about this multistep process: how electropermeabilization is related … |
| Diğer EP | Thalmensi et al · Oncoimmunology | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator | plazmid DNA · intratümöral | – | Human telomerase reverse transcriptase (hTERT) is overexpressed in more than 85% of human cancers regardless of their cellular origin. As immunological tolerance to hTERT can be overcome not… |
| Diğer EP | García-Sánchez et al · Bioelectrochemistry | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Darbe Parametrelerinin Optimizasyonu | – | – | – | – | In this study, electrical impedance spectroscopy measurements are performed during electroporation of monolayers of differentiated myotubes. The time resolution of the system (1 spectrum/ms)… |
| Diğer EP | Kranjc et al · Radiology | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator VITAE | – | – | Purpose: To investigate the feasibility of magnetic resonance (MR) electric impedance tomography ( EIT electric impedance tomography ) technique for in situ monitoring of electric field dist… |
| Diğer EP | Marčan et al · Biomed Eng Online | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Background: Treatments based on electroporation are a new and promising approach to treating tumors, especially non-resectable ones. The success of the treatment is, however, heavily depende… |
| Diğer EP | Xu et al · Bioelectrochemistry | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | BTX ECM830 | plazmid DNA | transfeksiyon verimi 75% | Electroporation is a commonly used approach to rapidly introduce exogenous molecules into cells without permanent damage. Compared to classical electroporation protocols, microchip-based ele… |
| IRE | Golberg et al · Sci Rep | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | BTX 830 pulse generator, BTX Tweezertrodes | – | – | Irreversible electroporation (IRE) is an emerging, minimally invasive technique for solid tumors ablation, under clinical investigation for cancer therapy. IRE affects only the cell membrane… |
| IRE | Serša · Biomed Eng Online | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | Cliniporator VITAE | – | ablasyon hacmi 60% (1 örnek) | Background: Electroporation is gaining its importance in everyday clinical practice of cancer treatment. For its success it is extremely important that coverage of the target tissue, i.e. tr… |
| ECT | Hudej et al · J Membr Biol | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Cliniporator | diğer · intravenöz | tam yanıt 18.8% (16 hayvan) | To increase electrochemotherapy (ECT) applicability, the effectiveness of new drugs is being tested in combination with electroporation. Among them two ruthenium(III) compounds, (imH)[trans-… |
| ECT | Spugnini et al · J Cell Physiol | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | – | Chemipulse III | sisplatin · intratümöral | hastalıksız sağkalım 0 ay (5 hasta) | Electrochemotherapy (ECT) is a cancer therapy that conjugates the administration of a chemotherapy agent to the delivery of permeabilizing pulses released singularly or as bursts. This appro… |
| Gen ET | Calvet · Mol Ther Methods Clin Dev | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator | plazmid DNA · intratümöral | – | DNA vaccination consists in administering an antigen-encoding plasmid in order to trigger a specific immune response. This specific vaccine strategy is of particular interest to fight agains… |
| Diğer EP | Pinyon et al · Sci Transl Med | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi | – | CUY21 | plazmid DNA · diğer yol | – | The cochlear implant is the most successful bionic prosthesis and has transformed the lives of people with profound hearing loss. However, the performance of the "bionic ear" is still largel… |
| Gen ET | Todorovic et al · Bioelectrochemistry | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | – | ELECTRO CELL B10 | plazmid DNA · intratümöral | – | Gene electrotransfer is an established method for plasmid delivery into different tissues. Contrary to extensive in vitro studies demonstrating increased gene electrotransfer by changing the… |
| Diğer EP | Kranjc et al · Physiol Meas | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi | – | Cliniporator VITAE | – | – | The electroporation effect on tissue can be assessed by measurement of electrical properties of the tissue undergoing electroporation. The most prominent techniques for measuring electrical … |
| Belirlenmedi | Aurisicchio et al · Oncoimmunology | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · diğer yol | – | Genetic vaccines are emerging as a powerful modality to induce T-cell responses to target tumor associated antigens (TAA). Viral or plasmid DNA or RNA vectors harbor an expression cassette e… |
| Diğer EP | Grys · Cell Mol Biol Lett | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | The recently described method of cell electroporation by flow of cell suspension through localized direct current electric fields (dcEFs) was applied to identify non-toxic substances that co… |
| IRE | Sano et al · Bioelectrochemistry | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | – | – | – | Under the influence of external electric fields, cells experience a rapid potential buildup across the cell membrane. Above a critical threshold of electric field strength, permanent cell da… |
| Diğer EP | Blagus et al · J Control Release | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Darbe Parametrelerinin Optimizasyonu | – | Cliniporator | diğer · topikal | – | Electroporation (EP) is a physical method for the delivery of molecules into cells and tissues, including the skin. In this study, in order to control the degree of transdermal and topical d… |
| Diğer EP | Chopinet et al · Biochim Biophys Acta | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | Jouan | – | – | Electropermeabilization is a physical method that uses electric field pulses to deliver molecules into cells and tissues. Despite its increasing interest in clinics, little is known about pl… |
| ECT | Markelc et al · PLoS One | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Vasküler Kilit (Vascular Lock) Etkisi, Antivasküler Etki ve Damar Yıkımı | – | – | bleomisin · intravenöz | – | Electropermeabilization/electroporation (EP) provides a tool for the introduction of molecules into cells and tissues. In electrochemotherapy (ECT), cytotoxic drugs are introduced into cells… |
| ECT | Pakhomova et al · J Cell Mol Med | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | S88K stimulator, custom-made high-voltage, low-output impedance electroporato | bleomisin | – | Cell permeabilization by electric pulses (EP), or electroporation, is widely used for intracellular delivery of drugs and plasmids, as well as for tumour and tissue ablation. We found that c… |
| Diğer EP | Wu et al · Sci Rep | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | BTX ECM830 | bleomisin | – | We present a multi-functional electroporation method for delivery of biomolecule utilizing a high-density distributed electrode network (HDEN) under tri-phase electric stimulation. The HDEN … |
| Diğer EP | Yun et al · Lab Chip | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi | – / 20 | BTX electroporation system | – | diğer 70% (20 lezyon) | We developed an on-chip microscale electroporation system that enables sequential delivery of multiple molecules with precise and independent dosage controllability into pre-selected identic… |
| Diğer EP | Zorec et al · Int J Pharm | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Cliniporator | – | – | Electroporation can be used as an active enhancement method for intra- and transdermal drug delivery. Differences in response of skin to electric pulses depend on their amplitude, duration a… |
| Diğer EP | Baldi · Front Biosci (Elite Ed) | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | – | Chemipulse | diğer · diğer yol | – | There is not a consensus on the best therapeutic approach to mesothelioma and the prognosis is still dismal. We have recently demonstrated that HtrA1 is a potential therapeutic target in mes… |
| Gen ET | Kamensek · Mol Cancer | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | GT-1 electroporator, Cliniporator | plazmid DNA · intratümöral | – | Background: Radiation induced transcriptional targeting is a gene therapy approach that takes advantage of the targeting abilities of radiotherapy by using radio inducible promoters to spati… |
| Diğer EP | Rosazza et al · Mol Ther | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | ElectroCell S20 | plazmid DNA · diğer yol | – | Electroporation is a physical method of transferring molecules into cells and tissues. It takes advantage of the transient permeabilization of the cell membrane induced by electric field pul… |
| IRE | Ben-David et al · Radiology | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 90 | NanoKnife | – | – | Purpose: To study the effects of the surrounding electrical microenvironment and local tissue parameters on the electrical parameters and outcome of irreversible electroporation (IRE) ablati… |
| IRE | Faroja et al · Radiology | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Purpose: To determine whether high-dose irreversible electroporation (IRE) ablation induces thermal effects in normal liver tissue. Materials and methods: Animal care and use committee appro… |
| IRE | Hjouj et al · Sci Rep | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | BTX 830 | – | – | To generate an understanding of the physiological significance of MR images of Non-Thermal Irreversible Electroporation (NTIRE) we compared the following MR imaging sequences: T1W, T2W, PD, … |
| IRE | Kim et al · Biochem Biophys Res Commun | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Apoptoz İndüksiyonu | – | Nano-porator | – | – | Irreversible electroporation is a novel method of ablating living tissues through its non-thermal effects, unlike radiofrequency ablation which has a severe problem of heat sink. It is due t… |
| IRE | Neal et al · PLoS One | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX Caliper Electrode | – | – | Irreversible electroporation (IRE) is a non-thermal focal ablation technique that uses a series of brief but intense electric pulses delivered into a targeted region of tissue, killing the c… |
| IRE | Sommer et al · J Vasc Interv Radiol | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | tam yanıt 20.6 mm (11 seans) | Purpose: To analyze irreversible electroporation (IRE) of the pig kidney with involvement of the renal pelvis. Materials and methods: IRE of renal tissue including the pelvis was performed i… |
| Diğer EP | Trujillo et al · Int J Hyperthermia | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması | – | Cool-tip, Cool-tip RF applicator | – | – | Purpose: The aim of this study was to assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA)… |
| ECT | Bellard et al · J Control Release | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Vasküler Kilit (Vascular Lock) Etkisi | – | Jouan GHT, Cliniporator | – | – | Electroporation/electropermeabilization, i.e. the result of the application of electric pulses to tissues, is a physical method for delivery of exogenous molecules into cells. It is effectiv… |
| ECT | Calmels et al · Technol Cancer Res Treat | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Bleomisin Hücre İçi Birikiminin Artması | – | GHT 1287 electropulsator | bleomisin · intravenöz | tümör hacmi değişimi -26% (6 hayvan) | In vivo cell electropermeabilization can be used alone or in combination with a hydrophilic, nonpermeant cytotoxic drug such as bleomycin (electrochemotherapy) to efficiently treat tumors. W… |
| Kalsiyum EP | Frandsen et al · Cancer Res | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Nekroz ve Nekroptoz | – | Cliniporator, BTX T820 square wave electroporator | kalsiyum klorür · intratümöral | tümör hacmi değişimi 89% (9 lezyon) | Electroporation of cells with short, high-voltage pulses causes a transient permeabilization of cell membranes that permits passage of otherwise nonpermeating ions and molecules. In this stu… |
| Diğer EP | Markelc et al · J Membr Biol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | – | plazmid DNA | – | Electropermeabilization/electroporation (EP) is a physical method that by application of electric pulses to cells increases cell membrane permeability and enables the introduction of molecul… |
| Diğer EP | Meschini et al · Eur J Cancer | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | Chemopulse | – · intratümöral | tümör hacmi değişimi 0.5 oran (5 lezyon) | Few articles in the literature have focused on electroporation as a strategy to reverse multidrug resistance (MDR) of tumour cells and they are mostly limited to the improved efficacy of ble… |
| ECT | Mozdarani et al · Cell J | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | ECT-SBDC | bleomisin · intratümöral | – | Objective: In electrochemotherapy (ECT), there is an unpleasant sensation of muscle contraction when using a low frequency (1 Hz). Therefore, by increasing the pulse frequency above the teta… |
| ECT | Pelofy et al · J Membr Biol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | S20u electropulsator, IGEA parallel plate electrodes | plazmid DNA | – | Despite great potential for disease treatment, small interfering RNA (siRNA) development has been hampered due to its poor stability and the lack of efficient delivery method. To overcome th… |
| Diğer EP | Van Lint et al · Cancer Res | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | plazmid DNA | – | The use of tumor-associated antigen (TAA) mRNA for therapeutic purposes is under active investigation. To be effective, mRNA vaccines need to deliver activation stimuli in addition to TAAs t… |
| Diğer EP | Arigoni et al · Angiogenesis | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Nekroz ve Nekroptoz | – | – | plazmid DNA · intratümöral | – | Angiomotin (Amot) is one of several identified angiostatin receptors expressed by the endothelia of angiogenic tissues. We have shown that a DNA vaccine targeting Amot overcome immune tolera… |
| Gen ET | Cemazar et al · Hum Gene Ther | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Ekstraselüler Matriks ve Doku İskeletinin Korunması | – | GHT 1287 | plazmid DNA · intratümöral | lokal kontrol 4 gün (12 lezyon) | One of the applications of electroporation/electropulsation in biomedicine is gene electrotransfer, the wider use of which is hindered by low transfection efficiency in vivo compared with vi… |
| Diğer EP | Chabot et al · Gene Ther | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Jouan CNRS cell electropulsator, Jouan PS 10 CNRS Electropulsator, CNRS cell electropulsator, PS 10 CNRS Electropulsator | plazmid DNA · diğer yol | – | A major issue for successful human gene therapy or genetic vaccination is a safe high-transgene expression level. Plasmid-based (non-viral) physical methods of gene transfer offered attracti… |
| Diğer EP | Choi et al · Small | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi, Gen Elektrotransferi (Plazmid DNA) | – | BTX ElectroCell Manipulator 600 | plazmid DNA | – | The impact of many biopharmaceuticals, including protein- and gene-based therapies, has been limited by the need for better methods of delivery into cells within tissues. Here, intracellular… |
| Diğer EP | Kardos et al · Hum Vaccin Immunother | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | MagPro R30, BTX T820 ElectroSquare Porator, MagPro R30 magnetic stimulator, C-100 magnetic applicator (coil) | plazmid DNA · intratümöral | kanama kontrolü 1004% (12 örnek) | Electroporation, an attractive process for delivering DNA and other molecules into target cells in vivo and in vitro is limited by the necessity of electrodes that need to be in contact with… |
| Diğer EP | Lin et al · Hum Gene Ther Methods | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | minimally invasive surface intradermal EP | plazmid DNA · intratümöral | progresyonsuz sağkalım 100% (10 hasta) | In vivo electroporation (EP) is an efficient nonviral method for enhancing DNA vaccine delivery and immunogenicity in animals and humans. Intradermal delivery of DNA vaccines is an attractiv… |
| Gen ET | Rosazza et al · Int J Pharm | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | CNRS cell electropulsator | plazmid DNA | – | The delivery of therapeutic molecules such as plasmid DNA in cells and tissues by means of electric fields holds great promise for anticancer treatment. To allow for their therapeutic action… |
| Diğer EP | García-Sánchez et al · J Membr Biol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | biphasic stimulator | – | – | In situ electroporation of adherent cells provides significant advantages with respect to electroporation systems for suspension cells, such as causing minimal stress to cultured cells and s… |
| IRE | Garcia et al · PLoS One | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Kan-Beyin Bariyeri Geçirgenliğinin Artması | – | BTX ECM830 | – | – | The blood-brain-barrier (BBB) presents a significant obstacle to the delivery of systemically administered chemotherapeutics for the treatment of brain cancer. Irreversible electroporation (… |
| IRE | LIU et al · Oncol Lett | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | electric pulses therapeutic system | – | – | Irreversible electroporation (IRE) is a new tumor ablation technique. Pulsed electric fields (PEFs) with permanent duration (100 μsec) permanently permeabilize the cell membrane, causing the… |
| IRE | Phillips et al · Br J Cancer | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | ECM 80, BTX Caliper Electrode | – | tam yanıt 100% (4 hayvan) | Background: Non-thermal irreversible electroporation (NTIRE) has recently been conceived as a new minimally invasive ablation method, using microsecond electric fields to produce nanoscale d… |
| IRE | Schoellnast et al · Eur Radiol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Objective: To evaluate the delayed effects of irreversible electroporation (IRE) ablation on nerves. Methods: The study was approved by the institutional animal care and use committee. CT-gu… |
| Diğer EP | Diao · World J Gastroenterol | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Nekroz ve Nekroptoz, Hemostaz ve Kanama Kontrolü | – | TERESA DNA delivery device | plazmid DNA · diğer yol | – | Aim: To investigate the effect of transgenic expression of kallistatin (Kal) on carbon tetrachloride (CCl(4))-induced liver injury by intramuscular (im) electrotransfer of a Kal-encoding pla… |
| ECT | Shankayi et al · J Membr Biol | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | ECT-SBDC | bleomisin · intratümöral | tam yanıt 20% (10 hayvan) | The most important unpleasant sensation of electrochemotherapy is muscle contraction. One of the causes of this discomfort is electrochemotherapy in the low-frequency range (1 Hz). To resolv… |
| Belirlenmedi | Vittorio et al · Nanotechnology | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | – | – | In this study we investigate the potential of multiwall carbon nanotubes (MWCNTs) with low metal impurities (2.57% iron) as magnetic resonance imaging (MRI) contrast agents. Taking into acco… |
| Diğer EP | Badea et al · DDL | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | BTX ECM830 | plazmid DNA · topikal | – | Gemini surfactant-lipid cationic nanoparticles (NP) and electroporation (EP) with a novel tape-electrode were evaluated in mice as topical delivery methods for plasmid DNA encoding luciferas… |
| Diğer EP | Donate et al · PLoS One | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi | – | – | plazmid DNA · diğer yol | tümör hacmi değişimi 5000 diğer (18 hayvan) | Current progress in the development of vaccines has decreased the incidence of fatal and non-fatal infections and increased longevity. However, new technologies need to be developed to comba… |
| Gen ET | Guo et al · J Control Release | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | – | UltraVolt Model Rack-2-500-00230 | plazmid DNA · intratümöral | – | Because of its large surface area and easy access for both delivery and monitoring, the skin is an attractive target for gene therapy for cutaneous diseases, vaccinations and several metabol… |
| Gen ET | Hojman et al · Hum Gene Ther | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator | kalsiyum klorür · intratümöral | transfeksiyon verimi 46% (7 hayvan) | Gene electrotransfer is expanding in clinical use, thus we have searched for an emergency procedure to stop transgene expression in case of serious adverse events. Calcium is cytotoxic at hi… |
| Diğer EP | Lin et al · Vaccine | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Dual-Depth Device, Elgen 1000, 4-needle array | – · intratümöral | – | Electroporation (EP) of either muscle or skin has proven to be an efficient method for increasing DNA-based vaccine delivery and immunogenicity in small and large animals. Previous comparati… |
| Gen ET | Markelc et al · Gene Ther | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Gen Elektrotransferi (Plazmid DNA) | – | GT-1 electropulsator, Jouan PS 10 electropulsator, Cliniporator | plazmid DNA · intratümöral | – | Electropermeabilization (EP) is an effective method of gene transfer into different tissues. During EP, reactive oxygen species (ROS) are formed, which could affect transfection efficiency. … |
| Diğer EP | Paganin-Gioanni et al · Proc Natl Acad Sci U S A | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | CNRS cell electropulsator | diğer | – | The RNA interference-mediated gene silencing approach is promising for therapies based on the targeted inhibition of disease-relevant genes. Electropermeabilization is one of the nonviral me… |
| Gen ET | Rosazza et al · Mol Ther | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | CNRS cell electropulsator | plazmid DNA | – | Electrotransfer of molecules is a well established technique which finds extensive use for gene transfer and holds great promise for anticancer treatment. Despite its widespread application,… |
| Diğer EP | Pucihar et al · IEEE Trans Biomed Eng | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – | Cliniporator, microsecond square wave pulse generator prototype, nanosecond pulse generator prototype | kalsiyum klorür | – | Electroporation-based applications require the use of specific pulse parameters for a successful outcome. When recommended values of pulse parameters cannot be set, similar outcomes can be o… |
| IRE | Golberg et al · Phys Med Biol | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | BTX 830 | – | – | Non-thermal irreversible electroporation (NTIRE) is a biophysical phenomenon which involves application of electric field pulses to cells or tissues, causing certain rearrangements in the me… |
| IRE | Li et al · PLoS One | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Background: If a critical nerve is circumferentially involved with tumor, radical surgery intended to cure the cancer must sacrifice the nerve. Loss of critical nerves may lead to serious co… |
| ECT | Sersa et al · J Membr Biol | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | Electrochemotherapy is an efficient local treatment of tumors that combines administration of a chemotherapeutic drug with the subsequent application of electric pulses to the tumor. Althoug… |
| ECT | Fantozzi et al · Bioelectrochemistry | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | – | three kV-porator | bleomisin | – | The achievement of electrochemotherapy was obtained using electrodes covered with guar gum (GG) hydrogel swollen in a sulfate bleomycin solution. The bleomycin delivery into the plasma membr… |
| Diğer EP | Napotnik et al · Med Biol Eng Comput | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | – | – | It has been reported previously that electric pulses of sufficiently high voltage and short duration can permeabilize the membranes of various organelles inside living cells. In this article… |
| Diğer EP | Anon · Molecular Therapy | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | – | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Anon · Molecular Therapy | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi | – | – | plazmid DNA · intratümöral | – | DNA electrotransfer to muscle tissue yields high-level, long-term expression of the transferred products. This is advantageous in many treatment regiments, but also poses a concern of how to… |
| Diğer EP | Anon · Molecular Therapy | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | plazmid DNA · intratümöral | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Anon · Molecular Therapy | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · intratümöral | – | NA Vaccine Delivery to Both Skin and Muscle Feng Lin,1 Jay McCoy,1 Xuefei Shen,1 Janess Mendoza,1 Kate E. Broderick,1 Jian Yan,3 Steve Kemmerrer,1 David B. Weiner,3 Niranjan Y. Sardesai.2 1 … |
| Diğer EP | Broderick et al · Gene Ther | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | – | ELGEN1000 | plazmid DNA · intratümöral | genel sağkalım 100% (10 hayvan) | The magnitude of the immune response to a DNA vaccine depends on three criteria--the optimized vector design, the use of a suitable adjuvant and the successful delivery and subsequent expres… |
| Diğer EP | Daugimont et al · J Membr Biol | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Cliniporator | plazmid DNA · intratümöral | – | The association of microneedles with electric pulses causing electroporation could result in an efficient and less painful delivery of drugs and DNA into the skin. Hollow conductive micronee… |
| Gen ET | Gothelf et al · Gene Ther | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | – | Cliniporator | – | – | Gene electrotransfer refers to gene transfection by electroporation and is an effective non-viral method for delivering naked DNA into cells and tissues. This study presents data from gene e… |
| ECT | Traitcheva et al · Bioelectrochemistry | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | BTX Electro Cell Manipulator-600 | diğer | – | In order to increase the permeability of cell membranes for low doses of cytostatic drugs, two bioelectrochemical methods have been compared: (a) electric pore formation in the plasma membra… |
| Gen ET | Vidic et al · Cancer Gene Ther | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – / 42 | GT-1 electroporator, Jouan GHT 1287 | – · intratümöral | tümör hacmi değişimi 0.993 oran (10 hayvan) | Mutations of K-ras have been found in 30-60% of colorectal carcinomas and are believed to be associated with tumor initiation, tumor progression and metastasis formation. Therefore, silencin… |
| Diğer EP | Anon · Molecular Therapy | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Bu yayında özet bulunmuyor. |
| IRE | Garcia et al · J Membr Biol | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | NanoKnife | – | – | Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive technique to treat cancer. It is unique because of its nonthermal mechanism of tumor ablation. Intracranial NTIRE … |
| ECT | Cör et al · Radiology and Oncology | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | – | – | bleomisin · intravenöz | – | Comparison between hypoxic markers pimonidazole and glucose transporter 1 (Glut-1) in murine fibrosarcoma tumours after electrochemotherapyBackground. Tumour hypoxia occurs as a result of an… |
| Gen ET | Hojman et al · PLoS One | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · intratümöral | – | Erythropoietin can be over-expressed in skeletal muscles by gene electrotransfer, resulting in 100-fold increase in serum EPO and significant increases in haemoglobin levels. Earlier studies… |
| Diğer EP | Ivorra et al · Phys Med Biol | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – / 39 | – | – | – | Electroporation is the phenomenon in which cell membrane permeability is increased by exposing the cell to short high-electric-field pulses. Reversible electroporation treatments are used in… |
| ECT | Kranjc et al · Radiat Res | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Jouan GHT 1287 electroporator | bleomisin · intravenöz | tümör hacmi değişimi 40.1 gün (8 hayvan) | Electrochemotherapy can potentiate the radiosensitizing effect of bleomycin, as shown in our previous studies. To bring this treatment closer to use in clinical practice, we evaluated the in… |
| ECT | Mazères et al · J Control Release | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – / 200 | CNRS Jouan PS 10 | sisplatin · intratümöral | nesnel yanıt 97% (200 lezyon) | For an effective tissue controlled electropermeabilization as requested for electrochemotherapy and electrogenotherapy, it is very important to have informations about the electric field dis… |
| ECT | Todorovic et al · Radiology and Oncology | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | – | bleomisin | hücre canlılığı 73% | Background. Electrochemotherapy is a local treatment combining application of electric pulses and chemotherapy. Two chemotherapeutic drugs, bleomycin and cisplatin, have proved to be effecti… |
| Diğer EP | Hojman et al · Biol Proced Online | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Cliniporator | plazmid DNA · diğer yol | – | DNA electrotransfer to muscle tissue yields long-term, high levels of gene expression; showing great promise for future gene therapy. We want to characterize the novel far-red fluorescent pr… |
| Diğer EP | Radkevich-Brown et al · Cancer Immunol Immunother | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım | – | BTX830 | plazmid DNA · intratümöral | tam yanıt 5 adet (9 hayvan) | In situ expression of a foreign antigen and an immune-modulating cytokine by intratumoral DNA electroporation was tested as a cancer therapy regimen. Transgene expression in the tumors was s… |
| Gen ET | Tevz et al · J Gene Med | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | – | – | plazmid DNA · intratümöral | – | Background: The present study aimed to evaluate the antitumor effectiveness of systemic interleukin (IL)-12 gene therapy in murine sarcoma models, and to evaluate its interaction with the ir… |
| Diğer EP | Cemazar et al · Gene Ther | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | Jouan electropulsator, Cliniporator | plazmid DNA · intratümöral | lokal kontrol 5% (6 hayvan) | Electrotransfer (electroporation) is recognized as one of the most promising alternatives to viral vectors for transfection of different tissues in vivo for therapeutic purposes. We evaluate… |
| IRE | Daniels et al · J Biomech Eng | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive surgical technique that is part of the emerging field of molecular surgery, which holds the potential to treat dis… |
| IRE | Granot et al · Phys Med Biol | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | BTX ECM830 | – | – | Electroporation, the increased permeability of cell membranes due to a large transmembrane voltage, is an important clinical tool. Both reversible and irreversible in vivo electroporation ar… |
| ECT | Sersa et al · Br J Cancer | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Antivasküler Etki ve Damar Yıkımı, Bleomisin Hücre İçi Birikiminin Artması | – | Jouan GHT 1287 electroporator | bleomisin · intravenöz | tam yanıt 6 adet (16 hasta) | Electrochemotherapy has a direct cytotoxic effect on tumour cells, and presumably, a vascular disrupting effect. In this study, on the basis of the prediction of the mathematical model, hist… |
| ECT | Ivorra et al · Phys Med Biol | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | bleomisin · intravenöz | – | Electroporation is used in tissue for gene therapy, drug therapy and minimally invasive tissue ablation. The electrical field that develops during the application of the high voltage pulses … |
| Diğer EP | Pucihar et al · Biophys J | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – | tropulsator (Jouan) | – | – | The transport of propidium iodide into electropermeabilized Chinese hamster ovary cells was monitored with a photomultiplier tube during and after the electric pulse. The influence of pulse … |
| ECT | Čorović et al · Technol Cancer Res Treat | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | Cliniporator | bleomisin · intravenöz | tam yanıt 7 adet (15 hayvan) | Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemot… |
| Diğer EP | Anon · Molecular Therapy | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | ELGEN 1000 | plazmid DNA · diğer yol | – | Bone marrow stromal cells (BMSC) are the adherent cells of the bone marrow and contain a subpopulation of mesenchymal stem cells. BMSC can be used in the treatment of multitude of diseases a… |
| Diğer EP | Benencia et al · J Transl Med | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu | – | Gene Pulser | plazmid DNA | – | Because of the lack of full characterization of tumor associated antigens for solid tumors, whole antigen use is a convenient approach to tumor vaccination. Tumor RNA and apoptotic tumor cel… |
| Diğer EP | Mesojednik et al · Radiology and Oncology | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | GT-1 electroporator | – | hücre canlılığı 33% | Evaluation of shRNA-mediated gene silencing by electroporation in LPB fibrosarcoma cellsBackground. Silencing oncogenes or other genes that contribute to tumor malignancy and progression off… |
| Gen ET | Tevz et al · Technol Cancer Res Treat | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Nekroz ve Nekroptoz | – | Cliniporator | plazmid DNA · intratümöral | transfeksiyon verimi 10% | Skeletal muscle is an attractive target tissue for delivery of therapeutic genes, since it is well vascularized, easily accessible, and has a high capacity for protein synthesis. For efficie… |
| Diğer EP | Anon · Molecular Therapy | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | plazmid DNA · diğer yol | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Anon · Molecular Therapy | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | plazmid DNA · intratümöral | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Anon · Molecular Therapy | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · intratümöral | – | Delivery Feng Lin,' Kate Broderick,' Jonas Soderholm,' Kristen Smits,' Torunn E. Tjelle,' Dietmar Rabussay,' lacob Mathiesen,' Rune Kjeken .' Research and Development, lnovio Biomedical Corp… |
| Gen ET | Cukjati et al · Bioelectrochemistry | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator, PS 15 | plazmid DNA · intratümöral | – | In vivo cell electroporation is the basis of DNA electrotransfer, an efficient method for non-viral gene therapy using naked DNA. The electric pulses have two roles, to permeabilize the targ… |
| Gen ET | Hojman et al · BMC Mol Biol | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator | plazmid DNA | – | Background: Gene transfer by electroporation (DNA electrotransfer) to muscle results in high level long term transgenic expression, showing great promise for treatment of e.g. protein defici… |
| Diğer EP | Hooper et al · Vaccine | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Easy Vax | plazmid DNA · intratümöral | genel sağkalım 100% (8 hayvan) | Previously, we demonstrated that an experimental smallpox DNA vaccine comprised of four vaccinia virus genes (4pox) administered by gene gun elicited protective immunity in mice challenged w… |
| Diğer EP | Granot et al · Physiol Meas | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Tissue electroporation is a medical technique in which electrical pulses of microsecond to millisecond length are applied to a tissue in order to permeabilize the membrane of targeted cells,… |
| IRE | Al-Sakere et al · Technol Cancer Res Treat | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | Cliniporator | – | – | Immune cell recruitment during the treatment of sarcoma tumors in mice with irreversible electroporation was studied by immunohistochemistry. Irreversible electroporation is a non-thermal ti… |
| IRE | Lee et al · Technol Cancer Res Treat | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Apoptoz İndüksiyonu | – | – | – | – | Preliminary results of percutaneous irreversible electroporation (PIE) on swine liver as a novel non-thermal ablation are presented. The goal of this study was to evaluate the feasibility of… |
| IRE | Maor et al · Technol Cancer Res Treat | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | We present a pilot study on the long term effects of irreversible electroporation (IRE) on a large blood vessel. The study was motivated by the anticipated use of IRE for treatment of cancer… |
| IRE | Rubinsky et al · Technol Cancer Res Treat | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 35 | DC pulse generator, Oncobionic | – | – | Irreversible electroporation (IRE) is a new tissue ablation technique in which micro to millisecond electrical pulses are delivered to undesirable tissue to produce cell necrosis through irr… |
| ECT | Cemazar et al · Anticancer Res | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | – | Jouan GHT 1287 | sisplatin · intratümöral | – | Background: The in vitro cytotoxic activity of two new platinum(II) complexes (3P-SK and PtAMP) in comparison with cisplatin (CDDP), oxaliplatin (OXA) and carboplatin (CARBO) was determined … |
| ECT | Cemazar et al · Biochem Biophys Res Commun | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | – | Jouan CNRS GHT 1287 | sisplatin · hem intravenöz hem intratümöral | – | Imaging methods can give both temporal and spatial dimensions to characterize the processes in progression of and/or treatment of specific disease Subcutaneous tumors can be cured after elec… |
| ECT | Labanauskiene et al · Medicina (Kaunas) | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intravenöz | – | By applying electric pulses to tumor the membrane of tumor cells undergoes destabilization that enables the drug molecules to enter into the cells more freely and selectivity of anticancer d… |
| Diğer EP | Mossop et al · Ann Biomed Eng | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi, Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM830 | – | – | The intratumoral field, which determines the efficiency of electric field-mediated drug and gene delivery, can differ significantly from the applied field. Therefore, we investigated the dis… |
| Diğer EP | Shil et al · J Environ Pathol Toxicol Oncol | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | BARC-RB&HSD/01-04 | diğer · intratümöral | tümör hacmi değişimi 53% (8 hayvan) | Treatment of cancer patients is subject to limitations in radiotherapy and chemotherapy. This necessitates development of new protocols, and the present work reports on the effects of a comb… |
| ECT | Soden et al · Cancer Lett | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | – | BTX ECM 2001 | bleomisin · intratümöral | tümör hacmi değişimi 0% (6 hayvan) | Electroporation is the application of very brief electric pulses to cells or tissues to render the cell membranes transiently and reversibly permeable, facilitating cellular uptake of otherw… |
| Diğer EP | Andre et al · Molecular Therapy | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | – | – | plazmid DNA · intratümöral | – | The major limitation of gene therapy is the vector used for gene transfer. Viruses were used first and are still the most common approach. Due to adverse events in clinical trials, there was… |
| Gen ET | Bloquel et al · BMC Biotechnol | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | BTX ECM830 | plazmid DNA · intratümöral | – | Background: Optical imaging is an attractive non-invasive way to evaluate the expression of a transferred DNA, mainly thanks to its lower cost and ease of realization. In this study optical … |
| Gen ET | Herrero-Fresneda et al · Kidney Int | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · diğer yol | – | Inflammatory processes and tissue scarring are characteristic features of chronic allograft nephropathy. Hepatocyte growth factor (HGF) has beneficial effects on renal fibrosis and it also a… |
| Diğer EP | Tjelle et al · Vaccine | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | Inovio pulse generator | plazmid DNA · diğer yol | – | Intramuscular injection of plasmid DNA followed by electrical stimulation (electroporation) is an efficient method for achieving therapeutic levels of encoded proteins or eliciting efficient… |
| IRE | Kandušer et al · Eur Biophys J | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | prototype electric pulse generator | bleomisin · intratümöral | – | In this paper, we report the results of a systematic attempt to relate the intrinsic plasma membrane fluidity of three different cell lines to their electroporation behaviour, which consists… |
| ECT | Larkin et al · Ir J Med Sci | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | – | 9 / 75 | – | bleomisin | tam yanıt 58.7% (75 lezyon) | SYLVESTER o'HALLORAN SURGICAL SCIENTIFIC MEETING • 4 - 5 MARCH 2005 • JEAN MONNET THEATRE, UNIVERSITY OF LIMERICK art" >,9R Modulation of coregulatory protein expression in human breast canc… |
| ECT | Miklavčič et al · Bioelectrochemistry | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | – | custom-built electropulsator | bleomisin · intravenöz | tam yanıt 36.8% (19 hayvan) | Muscle contractions present the main source of unpleasant sensations for patients undergoing electrochemotherapy. The contractions are a consequence of high voltage pulse delivery. Relativel… |
| ECT | Šatkauskas et al · Bioelectrochemistry | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | – | – | bleomisin · intravenöz | – | The aim of this study was to evaluate the effectiveness of electrochemotherapy (ECT) as a function of various combinations of pulse strength and duration. C57Bl mice bearing LLC tumors were … |
| Gen ET | Li et al · Mol Ther | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | Gentronics electroporator | plazmid DNA · diğer yol | tümör hacmi değişimi 6.2 oran (5 hayvan) | Injection of DNA via electric pulses into targeted tissues is referred to as electrotransfer. Intratumoral electrotransfer of the IL12 gene is more effective than intramuscular electrotransf… |
| Diğer EP | Šatkauskas et al · Hum Gene Ther | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | PS 15, Cliniporator | plazmid DNA · diğer yol | – | Efficient DNA electrotransfer can be achieved with combinations of short high-voltage (HV) and long low voltage (LV) pulses that cover two effects of the pulses, namely, target cell electrop… |
| ECT | Mali et al · J Med Eng Technol | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | – | – | The combined treatment of tumours in which delivery of a chemotherapeutic agent is followed by high voltage electroporation pulses has been termed electrochemotherapy. The electrochemotherap… |
| ECT | Soden et al · Conf Proc IEEE Eng Med Biol Soc | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi, Bleomisin Hücre İçi Birikiminin Artması | – | BTX ECM 2001 | bleomisin · intratümöral | tam yanıt 4 adet (6 hayvan) | Therapeutic "electroporation" involves application of electric fields to target cells/tissues, thereby rendering their cell membranes transiently porous, thus making feasible the cellular up… |
| Diğer EP | Maxim et al · Radiat Res | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | PA-4000 | diğer · intravenöz | – | Tumor hypoxia is associated with resistance to radiotherapy and anticancer chemotherapy. However, it can be exploited to therapeutic advantage by concomitantly using hypoxic cytotoxins, such… |
| Diğer EP | Pliquett et al · Bioelectrochemistry | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Elektrot Geometrisi ve Yerleşimi | – | Scientoporator | – | – | The artificial electrotransfer of bioactive agents such as drugs, peptides or therapeutical nucleic acids and oligonucleotides by membrane electroporation (MEP) into single cells and tissue … |
| Diğer EP | Cemazar · BMC Cancer | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | built in-house electroporator | plazmid DNA · topikal | transfeksiyon verimi 22% | Background: Electroporation is currently receiving much attention as a way to increase drug and DNA delivery. Recent studies demonstrated the feasibility of electrogene therapy using a range… |
| Diğer EP | Li et al · Mol Ther | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | Gentronics electroporator | plazmid DNA · intratümöral | tümör hacmi değişimi 40% | Interleukin-12 (IL-12) is one of the most effective cytokines for treating malignancy. Intratumoral delivery of the murine Il-12 gene, using electroporation, has been found effective in indu… |
| Diğer EP | Davalos et al · IEEE Trans Biomed Eng | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | Jouan PS-15, Jouan PS-15 square wave electropulsator | – | – | Electroporation is a method to introduce molecules, such as gene constructs or small drugs, into cells by temporarily permeating the cell membrane with electric pulses. In molecular medicine… |
| ECT | Kitamura · Cancer Chemother Pharmacol | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | – / 29 | CUY21 | – · intratümöral | tam yanıt 40 mm (10 hayvan) | Purpose: To determine whether or not low-voltage electrochemotherapy has cell killing effects. Materials: Dorsally transplanted NR-S1 carcinomas in mice were stimulated with electric pulses … |
| Diğer EP | Anon · Molecular Therapy | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | plazmid DNA · intratümöral | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Anon · Molecular Therapy | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım | – | – | plazmid DNA | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Anon · Molecular Therapy | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Genetronics pulse generator | – | genel sağkalım 1 adet | Bu yayında özet bulunmuyor. |
| ECT | Ivanov et al · J Gene Med | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | PS 15 | bleomisin · intratümöral | – | Background: MBD2 is a methylated DNA-binding protein that has been previously suggested to have transcriptional silencing as well as DNA demethylase activities. We have previously shown that… |
| Diğer EP | Davalos et al · Bioelectrochemistry | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi, Termal Etki ve Joule Isınması | – | – | – | – | Tissue electroporation is a technique that facilitates the introduction of molecules into cells by applying a series of short electric pulses to specific areas of the body. These pulses temp… |
| Diğer EP | Pliquett · Med Biol Eng Comput | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması, Elektrik Alan Dağılımı ve Modellemesi | – | Gene Pulser | bleomisin | – | The application of high-voltage pulses to biological tissue causes not only electroporation, a non-thermal phenomenon of pore creation within a lipid membrane due to an elevated electric fie… |
| ECT | Dujardin · J Control Release | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Doku İletkenliği ve Empedans Değişimi | – | Cytopulse PA-4000 | – | – | The application of short-duration high-voltage pulses to the skin has been shown to enhance transdermal drug delivery by several orders of magnitude and to transiently permeabilize cells in … |
| ECT | Heller et al · Technol Cancer Res Treat | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | – | MedPulser | bleomisin · intratümöral | – | The efficient delivery of drugs to tumors is an important tool for the treatment of a variety of cancers. Electric pulses have been shown to facilitate the uptake of molecules through the ce… |
| ECT | Mitsui et al · Drug Deliv | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | Model T-820 | bleomisin · intravenöz | tam yanıt 5 adet (5 hayvan) | We investigated the cytotoxicity on the combination of bleomycin (BLM) with electric pulses against transplanted bladder tumors in nude mice. Loading with high-voltage electric pulse after i… |
| Diğer EP | Golzio et al · Proc Natl Acad Sci U S A | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | CNRS cell electropulsator | plazmid DNA | transfeksiyon verimi 0% | Electropermeabilization is one of the nonviral methods successfully used to transfer genes into living cells in vitro and in vivo. Although this approach shows promise in the field of gene t… |
| Diğer EP | Li · J Natl Cancer Inst | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım | – | BTX ECM830 | plazmid DNA · intratümöral | tümör hacmi değişimi 15 oran | Background Interleukin 12 (IL-12) is a proinflammatory cytokine with antitumor activity. Plasmid-based intratumoral gene therapy for treating malignancy with IL-12 or other genes is safe, in… |
| Diğer EP | Satkauskas et al · Mol Ther | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | gene transfection module, PS 15 | – · intratümöral | – | Efficient cell electrotransfection can be achieved using combinations of high-voltage (HV; 800 V/cm, 100 micros) and low-voltage (LV; 80 V/cm, 100 ms) pulses. We have developed equipment all… |
| ECT | Lebar et al · Anticancer Res | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | – | Jouan GHT 1287 B | – · intravenöz | tam yanıt 4 adet (9 hasta) | The aim of our study was to optimise electric pulse parameters for electrochemotherapy by sampling the space of pulse parameter variables using systematic in vitro experiments. For this purp… |
| ECT | Cemazar et al · Eur J Cancer | 2001 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | – | Jouan GHT 1287 | sisplatin · intravenöz | tam yanıt 19% | The aim of the study was to determine whether electrochemotherapy with cisplatin could be implemented in treatment of cisplatin-resistant solid tumours. For this purpose, we used cisplatin-s… |
| ECT | Kranjc et al · European Journal of Cancer | 2001 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Antivasküler Etki ve Damar Yıkımı | – | – | sisplatin | – | There is abundant evidence that t u m o r - ~ Ixnteelylicfactms uPA type l~lasminogen_activator)and its inhibitorPAI-1 play a key role in tum~ invmion and metastasis. Elevated levels of thes… |
| Diğer EP | Lucas et al · DNA Cell Biol | 2001 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | – | PA4000 DC pulse generator | plazmid DNA · diğer yol | – | In vivo electroporation is currently accomplished by one of two types of common waveforms: exponential decay or square-wave pulses. The purpose of this report is to present a new electropora… |
| Diğer EP | Cemazar et al · Br J Radiol | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Jouan GHT 1278 | diğer · intravenöz | – | For effective boron neutron capture therapy (BNCT) it is important that a sufficient concentration of boron (10B) is present in the tumour during irradiation. This requirement represents a s… |
| Diğer EP | Kotnik et al · Biotechniques | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | GHT 1287B, GHT 1287B electropulsator | bleomisin | – | For the evaluation of cell membrane electropermeabilization, cells are usually exposed to electric pulses in the presence of propidium iodide, a fluorescent dye activated by binding to cellu… |
| ECT | Serša et al · Int J Radiat Oncol Biol Phys | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Jouan GHT 1287 | sisplatin · intravenöz | – | Purpose: To evaluate whether a local drug delivery method, i.e., electroporation of tumors, increases the radiosensitizing effect of cisplatin. Methods and materials: Subcutaneous Ehrlich-Le… |
| Diğer EP | Goto et al · Proc Natl Acad Sci U S A | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | – | T820 square-wave electroporator | plazmid DNA · intratümöral | – | We report successful electro-gene therapy (EGT) by using plasmid DNA for tumor-bearing mice. Subcutaneously inoculated CT26 tumor was subjected to EGT, which consists of intratumoral injecti… |
| ECT | Miklavčič et al · Biochim Biophys Acta | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | PS 15 | bleomisin · intravenöz | – | Permeabilising electric pulses can be advantageously used for DNA electrotransfer in vivo for gene therapy, as well as for drug delivery. In both cases, it is essential to know the electric … |
| ECT | Cemazar et al · Br J Cancer | 1999 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – | Jouan GHT 1287 | sisplatin · intravenöz | – | Electrochemotherapy is an anti-tumour treatment that utilizes locally delivered electric pulses to increase cytotoxicity of chemotherapeutic drugs. The aim of our study was to determine whet… |
| ECT | Sersa et al · Anticancer Res | 1999 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Vasküler Kilit (Vascular Lock) Etkisi | – | Jouan GHT 1287 | bleomisin · intravenöz | tam yanıt 70% (34 hayvan) | Background: Electrochemotherapy combines administration of the chemotherapeutic drug, followed by application of electric pulses in order to increase drug delivery into the cells. The aim of… |
| Diğer EP | Mir et al · Proc Natl Acad Sci U S A | 1999 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | PS 15, T820 electroporator | plazmid DNA · intratümöral | – | Gene delivery to skeletal muscle is a promising strategy for the treatment of muscle disorders and for the systemic secretion of therapeutic proteins. However, present DNA delivery technolog… |
| ECT | Gehl et al · Anticancer Drugs | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | – | – | Electropermeabilization (EPN), also termed electroporation, is a physical method to overcome the barrier of the cell membrane by applying short and intense electric pulses. It is the basis f… |
| Diğer EP | Neumann et al · Biophys J | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | – | Electroporator II | diğer · diğer yol | – | The color change of electroporated intact immunoglobulin G receptor (Fc gammaR-) mouse B cells (line IIA1.6) after direct electroporative transfer of the dye SERVA blue G (Mr 854) into the c… |
| Diğer EP | Serŝa et al · Electro- and Magnetobiology | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | Jouan GHT 1287 | – | – | The effect of application of short, intense electric pulses on tumor blood volume was investigated using albumin-(Gd-DTPA)30 contrast-enhanced magnetic resonance imaging (MRI). One of paired… |
| ECT | Čemazar et al · Anticancer Drugs | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | – | Jouan GHT 1287 | sisplatin | – | Electrochemotherapy using intratumoral cisplatin administration was tested on EAT tumors in mice. Mice were treated with eight electric pulses (100 micros, 1 Hz, 1040 V) and/or cisplatin (1,… |
| ECT | Čemažar et al · Jpn J Cancer Res | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | Jouan GHT 1287 electropulsator | bleomisin · intravenöz | tümör hacmi değişimi 0% | Electrochemotherapy (ECT) involves the use of locally applied electric pulses to increase delivery of chemotherapeutic drugs into cells in tissues. ECT with bleomycin (BLM) is a very effecti… |
| ECT | Šemrov et al · Comput Biol Med | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | – | bleomisin · intravenöz | – | Electrochemotherapy is a novel approach in chemotherapeutic drug delivery into tumours. Short intense direct current electric pulses are applied to tumour tissue causing electropermeabilisat… |
| ECT | Miklavčič et al · Biophys J | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | Jouan GHT 1287 | bleomisin · intravenöz | – | Cells exposed to short and intense electric pulses become permeable to a number of various ionic molecules. This phenomenon was termed electroporation or electropermeabilization and is widel… |
| ECT | Serša et al · Cancer Lett | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Jouan GHT 1287 | bleomisin · intravenöz | – | With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tum… |
| ECT | Serša et al · Magn Reson Med | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | The use of electric current density imaging (CDI) to map spatial distribution of electric currents through tumors is presented. Specifically, a method previously tested on phantoms was imple… |
| Diğer EP | Zhang et al · Bioelectrochemistry and Bioenergetics | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | ECM 600 Electro Cell Manipulator | diğer · topikal | kısmi yanıt 36% | Successful development of a noninvasive topical-based delivery system ,ff therapeutic ageing, with a handy a~licator, will allow for targeted and efficient in vivo gene transfer without the … |
| ECT | Gilbert et al · Biochim Biophys Acta | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi | – | T820, T820 pulse generator | bleomisin · intratümöral | tam yanıt 97.1% (34 hayvan) | Direct current pulses for electrochemotherapy treatment are typically administered using two parallel plate electrodes that are placed on either side of the tumor. This simple design has pro… |
| ECT | Jaroszeski et al · Melanoma Res | 1996 | Hayvan Çalışması | Hayvan (İn Vivo) | – | – | – | – | – | Electrochemotherapy has been demonstrated to be an effective treatment for cutaneous cancers. The treatment includes administering a chemotherapeutic agent followed by electric pulses which … |
| ECT | Serša et al · Bioelectrochemistry and Bioenergetics | 1996 | Hayvan Çalışması | Hayvan (İn Vivo) | Transmembran Potansiyel Değişimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Jouan GHT 1287 | bleomisin · intravenöz | – | Electrochemotherapy is a new and promising approach in treatment of tumors employing locally applied high voltage d.c. electric pulses in combination with chemotherapeutic drugs. Increased p… |
| ECT | Sersa et al · Anticancer Drugs | 1996 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | – | – | – | – | Electrochemotherapy is an antitumor treatment that utilizes locally delivered electric pulses to increase the effectiveness of chemotherapeutic drugs in cells and tissues. Electric pulses pe… |
| Diğer EP | Gabriel ve Teissie · Eur J Biochem | 1995 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | CNRS electropulser | – | – | When electropulsed by short strong electric field pulses, cells can be permeabilized transiently (electropermeabilization). The transient electroinduced membrane restructuration which suppor… |
| Diğer EP | Rols et al · Biochem Biophys Res Commun | 1995 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | – | – | Electropermeabilization is a technique which allows free access of molecules to cytosol. In the present study, we report on results dealing with the penetration of macromolecules. Under elec… |
| ECT | Sersa et al · Cancer Res | 1995 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Darbe Parametrelerinin Optimizasyonu | – | Electropulsator Jouan GHT 1287 | sisplatin · intravenöz | – | One of the ways to increase drug delivery into cells and tissues is by a local application of short, intense electric pulses, i.e., electropermeabilization. This approach is used in electroc… |
| Diğer EP | EL OUAGARI et al · Eur J Biochem | 1994 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | CNRS electropulser | – | – | Electropulsation allowed us to incorporate glycophorin A, an integral membrane protein, into mammalian nucleated cell membranes (Chinese hamster ovary cells). The induction of stable protein… |
| Diğer EP | Jean Belehradek et al · Biochim Biophys Acta | 1994 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | PS 15 | bleomisin · intravenöz | – | Using cells in suspension, electropermeabilization is a technique extensively used to transfect living cells or to introduce a variety of compounds inside the cells. Here we demonstrate the … |
| ECT | Serša et al · Bioelectrochemistry and Bioenergetics | 1994 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Jouan GHT 1287 | bleomisin · intravenöz | tam yanıt 62% (19 hayvan) | Electrochemotherapy is a new approach in the treatment of tumors that takes advantage of the permeabilization of the cell membrane by electric pulses to facilitate the delivery of chemothera… |
| Diğer EP | TEISSIE et al · Ann N Y Acad Sci | 1994 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | CNRS electropulser | – | – | Electropermeabilization is a convenient technique to gain access to the cytoplasm. It appears not to be drastic for the cells, has the advantages of high reproducibility and reversibility, a… |
| ECT | M Belehradek, C Domenge, B Luboinski, S Orlowski, J Belehradek, L Mir · Cancer | 1993 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | 8 / 40 | PS 15 | bleomisin · intravenöz | tam yanıt 57% (40 lezyon) | Electrochemotherapy is a new antitumor treatment consisting of electrical pulses administered to the tumor several minutes after intravenous injection of bleomycin. In mice, important antitu… |
| Diğer EP | Rols et al · Biochim Biophys Acta | 1992 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | – | – | Chinese hamster ovary (CHO) cells and human erythrocytes were pulsed by using square-wave electric-field pulses. This treatment induced their permeabilization. This phenomenon appears to be … |
| ECT | Mir et al · Eur J Cancer | 1991 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – / 24 | – | bleomisin · intravenöz | tümör hacmi değişimi 14.3 gün (6 hayvan) | In cell culture the cytotoxicity of some anticancer drugs, especially bleomycin, can be greatly enhanced by exposing cells to non-cytotoxic electric pulses. Nude or conventional mice bearing… |
| Diğer EP | Rols et al · Biochemistry | 1990 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | CNRS cell electropulsator | – | – | Cells can be made temporarily permeable if pulsed by high-intensity short-duration electric fields. The molecular mechanisms underlying this electropermeabilization are still unknown. The ki… |
| Diğer EP | Mir et al · Exp Cell Res | 1988 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | – | – | diğer | – | The possibility of introducing definite amounts of nonpermeant molecules into electropermeabilized living cells has been approached by quantifying the amounts of Lucifer Yellow (LY; a 457-Da… |
| Diğer EP | Orlowski et al · Biochem Pharmacol | 1988 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | – | – | The electropermeabilization (EPN) of living cells allows the uptake of non-permeant molecules and can reveal their potential activity on cells without the constraints of the plasma membrane … |
| Diğer EP | Szwedowicz et al · Biomed Pharmacother | 2026 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Petri Pulser™ | – | hücre canlılığı 20.42% | Background: Electroporation (EP) is widely applied in electrochemotherapy to enhance drug delivery by transient membrane permeabilization. However, its impact on intercellular communication … |
| ECT | Alkis et al · Bioorg Chem | 2026 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | BTX GeminiX2 | diğer | hücre canlılığı 28.15% | A novel niraparib-derived Schiff base (Sb) ligand and its Pd(II) and Fe(II) complexes were synthesized and comprehensively characterized using elemental and thermal analyses, 1 H, 13 C NMR, … |
| Diğer EP | Giovannini et al · Bioelectrochemistry | 2026 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | ElectroCELL B15 | diğer · diğer yol | – | Electroporation is a promising technique for enhancing the delivery of therapeutic agents by transiently increasing cell membrane permeability through high-amplitude (from hundreds of V/cm t… |
| Kalsiyum EP | Gürsoy et al · Cukurova Med J | 2026 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Apoptoz İndüksiyonu | – | BTX ECM830 | kalsiyum klorür | hücre canlılığı 63.16% | Purpose: This study aimed to evaluate the effects of calcium electroporation on cell viability, energy metabolism, and cell survival signaling pathways in the colon cancer cell line DLD-1.Ma… |
| ECT | Neville et al · Radiol Oncol | 2026 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – | Neon Transfection System | sisplatin | – | Background: Reversible electroporation involves the use of pulsed electric fields to temporarily disrupt and permeabilise cell membranes. Electroporation combined with chemotherapy - electro… |
| Diğer EP | Xia et al · Bioelectrochemistry | 2026 | İn Vitro Çalışma | Hücre Kültürü | Termal Etki ve Joule Isınması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | BTX Electro Cell Manipulator 600 | – | – | Microneedle electroporation holds promise for enhancing dermal gene and drug delivery, yet the biophysical consequences of millisecond exponential-decay pulses remain incompletely characteri… |
| Diğer EP | Polajžer et al · Bioelectricity | 2026 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Introduction: High-intensity pulsed electromagnetic fields (HI-PEMF) can be used to trigger contactless permeabilization of the plasma membrane similar to electroporation (EP). The permeabil… |
| IRE | Batista Napotnik et al · Sci Rep | 2026 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Kalsiyum Homeostazının Bozulması | – | – | – | – | In recent years, irreversible electroporation has been increasingly used to treat cardiac arrhythmias, an approach termed pulsed field ablation. The mechanisms of how electroporation affects… |
| IRE | Han et al · Biomater Res | 2026 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 1 | – | – | – | Irreversible electroporation (IRE) remodels the tumor microenvironment to enhance biomaterial and nanoparticle (NP) delivery and immune activation, making combinational IRE-nanomedicine a pr… |
| IRE | Vallin · Bioeng Transl Med | 2026 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) is a focal ablative cancer therapy that destroys cells through membrane destabilization via pulsed electric fields. It also has the capacity to induce a sy… |
| ECT | Plešnik et al · J Pharm Biomed Anal | 2025 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | – | laboratory prototype pulse generator, CellFX System | bleomisin | – | Bleomycin, a cytotoxic antibiotic, poses substantial challenges for mass spectrometry-based analysis due to its extreme polarity, chelating properties, heterogeneity of fractions, and propen… |
| IRE | Murthy · Cancers (Basel) | 2025 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | Canady Helios Cold Plasma XL-1000 CP System, Canady Helios Cold Plasma (CHCP) system | diğer · diğer yol | – | Background: The Canady Helios Cold Plasma (CHCP) system is a non-thermal, non-contact cold atmospheric plasma technology that generates transient electric fields and reactive species capable… |
| IRE | Wang et al · Bioelectrochemistry | 2025 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu, Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | – | – | – | Sirtuin proteins have key roles in cancer progression and metastases. However, their role in bioelectrical modulation via high-frequency irreversible electroporation (H-FIRE) remains poorly … |
| IRE | Williamson et al · J Vis Exp | 2025 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | plazmid DNA · topikal | – | Electroporation is a promising technology utilizing electrical pulses for macromolecule delivery and soft-tissue ablation, with applications that include next-generation prophylactics and th… |
| Diğer EP | Batista Napotnik et al · J Vis Exp | 2024 | İn Vitro Çalışma | Hücre Kültürü | Transmembran Potansiyel Değişimi | – | – | – | – | Excitable cells such as neuronal and muscle cells can be primary targets in rapidly emerging electroporation-based treatments. However, they can be affected by electric pulses even in therap… |
| ECT | Calvel et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2024 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Jouan GHT 1287 | bleomisin · diğer yol | – | Among all the cancer treatments developed, electrochemotherapy has shown great promise in recent decades. This approach combines the local delivery of electric pulses with the administration… |
| Diğer EP | Choromańska et al · Biochim Biophys Acta Gen Subj | 2024 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | – | BTX ECM830 | bleomisin | – | Although the pulse electric field (PEF) has been used in electrochemotherapy (ECT) for many years, the kinetics and profile of extracellular particles (EPs) released as a result of reversibl… |
| Kalsiyum EP | Lisec · Cell Commun Signal | 2024 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Kalsiyum Homeostazının Bozulması | – | Jouan GHT beta pulse generator | kalsiyum klorür · diğer yol | – | Background: Disruption of Ca 2+ homeostasis after calcium electroporation (CaEP) in tumors has been shown to elicit an enhanced antitumor effect with varying impacts on healthy tissue, such … |
| ECT | Lopes et al · Med Eng Phys | 2024 | İn Vitro Çalışma | Hücre Kültürü | Elektrot Geometrisi ve Yerleşimi, Elektrik Alan Dağılımı ve Modellemesi | 1 / 1 | – | – | – | Electrochemotherapy is a cancer treatment in which local pulsed electric fields are delivered through electrodes. The effectiveness of the treatment depends on exposing the tumor to a thresh… |
| Diğer EP | Mondal et al · J Membr Biol | 2024 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversi… |
| Kalsiyum EP | Radzevičiūtė-Valčiukė et al · Bioelectrochemistry | 2024 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Reversible Membran Permeabilizasyonu | – | adı bildirilmemiş elektroporatör | kalsiyum klorür | – | Calcium electroporation is a modality of electrochemotherapy (ECT), which is based on intracellular electric field-mediated delivery of cytotoxic doses of calcium into the cells resulting in… |
| IRE | Strucic et al · Radiol Oncol | 2024 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | L-POR V0.1 | diğer | – | Background: Administering gadolinium-based contrast agent before electroporation allows the contrast agent to enter the cells and enables MRI assessment of reversibly electroporated regions.… |
| ECT | Zamuner et al · Bioelectrochemistry | 2024 | İn Vitro Çalışma | Hücre Kültürü | Ekstraselüler Matriks ve Doku İskeletinin Korunması, Transmembran Potansiyel Değişimi | – | EPS-02 | – | – | Electrochemotherapy (ECT) with bleomycin is an effective antitumor treatment. Still, researchers are investigating new drugs and electroporation conditions to improve its efficacy. To this a… |
| Diğer EP | Pavlin et al · Biomed Eng Online | 2024 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | BetaTech | – | – | Background: Electrotransfection is based on application of high-voltage pulses that transiently increase membrane permeability, which enables delivery of DNA and RNA in vitro and in vivo. It… |
| Diğer EP | Torabi et al · Biomed Eng Online | 2024 | İn Vitro Çalışma | Hücre Kültürü | – | – | Eppendorf Eporator | – | – | Background: Extracellular vesicles (EVs) have emerged as an exciting tool for targeted delivery of therapeutics for a wide range of diseases. As nano-scale membrane-bound particles derived f… |
| Gen ET | Ušaj et al · – | 2024 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | – | – | plazmid DNA | – | In the search for safe induction of cellular and humoral cancer immunity dendritic cell-based therapies hold great potential. This approach is based on manipulation of dendritic cells to act… |
| Diğer EP | Collin · ESAIM: COCV | 2024 | İn Vitro Çalışma | Hücre Kültürü | – | – | – | – | – | The estimation of partial differential systems (PDE) – in particular, the identification of their parameters – is fundamental in many applications to combine modeling and available measureme… |
| Diğer EP | Müller et al · Sci Rep | 2024 | İn Vitro Çalışma | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması, İrreversible Por Oluşumu ve Hücre Ölümü | – | IGEA Genedrive | – | – | Medical devices and technologies must undergo extensive testing and validation before being certified for public healthcare use, especially in oncology where a high research focus is on new … |
| IRE | Lv et al · IEEE Trans Biomed Eng | 2024 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | custom-built CBPs generator | – | – | Unlabelled: The H-FIRE (high-frequency irreversible electroporation) protocol employs high-frequency bipolar pulses (HFBPs) with a width of ∼1 µs for tumor ablation with slight muscle contra… |
| ECT | Kranjc Brezar et al · Bioelectrochemistry | 2023 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | ELECTROcell B10 HVLV | diğer | hücre canlılığı 87% | Electrochemotherapy (ECT) is a local ablative therapy for the treatment of different skin and subcutaneous tumors and certain tumors in internal organs. Skeletal muscle represents a major tu… |
| Gen ET | Kranjc et al · Int J Mol Sci | 2023 | İn Vitro Çalışma | Hücre Kültürü | İmmünojenik Hücre Ölümü (ICD), Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | High-Intensity Pulsed Electromagnetic Fields (HI-PEMF) treatment is an emerging noninvasive and contactless alternative to conventional electroporation, since the electric field inside the t… |
| ECT | Lin et al · Talanta | 2023 | İn Vitro Çalışma | Hücre Kültürü | Ekstraselüler Matriks ve Doku İskeletinin Korunması | – | – | diğer | – | Cell density is important for tumour metastasis, treatment and prognosis. Characterizing changes in cell density for electrochemotherapy (ECT) can reveal sub-populations in pathological stat… |
| Kalsiyum EP | Lisec et al · – | 2023 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Darbe Parametrelerinin Optimizasyonu | – | Jouan GHT beta pulse generator | kalsiyum klorür | – | Background The vascular endothelium consists of endothelial cells (ECs) with important biological functions, and their impairment is associated with various pathologies. ECs vary based on ti… |
| Gen ET | Komel et al · Bioelectrochemistry | 2023 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | – | Fluorescent reporter genes are widely used to study the transfection of various types of primary cells and cell lines. The aim of our research was to investigate the expression dynamics of G… |
| IRE | Polajžer et al · Vaccines (Basel) | 2023 | İn Vitro Çalışma | Hücre Kültürü | İmmünojenik Hücre Ölümü (ICD), Darbe Parametrelerinin Optimizasyonu | – | laboratory prototype pulse generator, L-POR V0.1, CellFX System, FPG20-1NM4 | – | – | Traditionally, electroporation-based therapies such as electrochemotherapy (ECT), gene electrotransfer (GET) and irreversible electroporation (IRE) are performed with different but typical p… |
| Gen ET | de Caro et al · Pharmaceutics | 2023 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | ELECTROCELL S20, ELECTROCELL B15 | – | – | Electroporation, a method relying on a pulsed electric field to induce transient cell membrane permeabilization, can be used as a non-viral method to transfer genes in vitro and in vivo. Suc… |
| ECT | Vélez Salazar et al · Biophys J | 2023 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Vasküler Kilit (Vascular Lock) Etkisi | – | – | diğer · intravenöz | – | The convective delivery of chemotherapeutic drugs in cancerous tissues is directly proportional to the blood perfusion rate, which in turns can be transiently reduced by the application of h… |
| IRE | Peng et al · Ann Biomed Eng | 2023 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu | – | laboratory prototype pulse generator, L-POR V0.1, CellFX System, FPG20-1NM4 | – | – | The mechanisms of cell death due to electroporation are still not well understood. Recent studies suggest that cell death due to electroporation is not an immediate all-or-nothing response b… |
| ECT | Wolff et al · Biomedicines | 2022 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, İmmünojenik Hücre Ölümü (ICD) | – | BTX ECM830 | – | – | In modern oncology, therapies are based on combining monotherapies to overcome treatment resistance and increase therapy precision. The application of microsecond-pulsed electric fields (PEF… |
| ECT | Andrade et al · Sci Rep | 2022 | İn Vitro Çalışma | Hücre Kültürü | Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Electrochemotherapy is a selective electrical-based cancer treatment. A thriving treatment depends on the local electric field generated by pairs of electrodes. Electrode damage as deflectio… |
| ECT | Bendix et al · Bioelectrochemistry | 2022 | İn Vitro Çalışma | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM 2001, BTX ECM 2001 square wave electroporator | sisplatin · diğer yol | – | Electrochemotherapy (ECT) is becoming an established therapy for melanoma and is under investigation for application in additional cancer types. One potential cancer type that may benefit fr… |
| ECT | Gursoy et al · Med Oncol | 2022 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | BTX ECM830 | bleomisin | hücre canlılığı 67.58% | Low-dose chemotherapy in advanced stages of cancer does not give a positive response in treatment. The use of high-dose antineoplastic drugs creates significant side effects. The limiting si… |
| IRE | Lv et al · Bioelectrochemistry | 2022 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation achieved by the application of pulsed electric field is successfully used for clinical tumor ablation. Electrochemotherapy (ECT) and irreversible electroporation (IRE), which… |
| Diğer EP | Novickij et al · Biochim Biophys Acta Biomembr | 2022 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | – | VGTU pulse generator | kalsiyum klorür · diğer yol | – | Pulsed electric fields (PEFs) are commonly used to facilitate the delivery of various molecules, including pharmaceuticals, into living cells. However, the applied protocols still require op… |
| Diğer EP | Watanabe et al · Sensors (Basel) | 2022 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Doku İletkenliği ve Empedans Değişimi | – | – | diğer | – | Membrane permeabilization stimulated by high-voltage electric pulses has been used to deliver cell-impermeable exogenous molecules. The electric field effect on the cells depends on various … |
| Diğer EP | Brooks et al · Biosens Bioelectron | 2022 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Transmembran Potansiyel Değişimi | – | Bio-Rad Gene Pulser II Electroporation System with RF Module | – | hücre canlılığı 100% (40 bildirilmemiş) | In vitro intracellular delivery is a fundamental challenge with no widely adopted methods capable of both delivering to millions of cells and controlling that delivery to a high degree of ac… |
| IRE | Collin et al · AIMSBOA | 2022 | İn Vitro Çalışma | Hücre Kültürü | – | – | Electrocell S 20, Electrocell S 20 generator | – | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Poulkouras et al · Bioelectrochemistry | 2022 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Kalsiyum Homeostazının Bozulması | – | – | – | – | Glioblastoma Multiforme is a highly lethal form of brain cancer, resistant to traditional therapeutic approaches and oftentimes hardly resectable. The application of pulsed electric fields (… |
| IRE | Petrella et al · IEEE Trans Biomed Eng | 2022 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | square wave generator based on capacitive discharge | – | – | Expanding the volume of an irreversible electroporation treatment typically necessitates an increase in pulse voltage, number, duration, or repetition. This study investigates the addition o… |
| ECT | Alkış et al · Journal of Molecular Structure | 2021 | İn Vitro Çalışma | Hücre Kültürü | – | – | Gene Pulsar Xcell TM | diğer · diğer yol | hücre canlılığı 36.35% (4 örnek) | In this study, a new Schiff base ligand and its two M(II) complexes [CoCl·L(H2 O)2 ]·2H2 O, [RuCl(pcymene)L] were synthesized. The structural features were confirmed from their micro analytic… |
| Diğer EP | Lira et al · Adv Sci (Weinh) | 2021 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | Eppendorf multiporator | – | – | Resealing of membrane pores is crucial for cell survival. Membrane surface charge and medium composition are studied as defining regulators of membrane stability. Pores are generated by elec… |
| ECT | Lopes et al · Med Eng Phys | 2021 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – / 1 | – | bleomisin | – | Electrochemotherapy (ECT) requires covering the entire tumor and safe margins with a suitable pulsed electric field (PEF). The PEF distribution depends on the biological and electrical param… |
| ECT | Szlasa et al · Int J Mol Sci | 2021 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | – | BTX square wave electroporator | kalsiyum klorür | – | Electroporation is influenced by the features of the targeted cell membranes, e.g., the cholesterol content and the surface tension of the membrane. The latter is eventually affected by the … |
| ECT | Yadegari-Dehkordi et al · Cell J | 2021 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | – | ECT-SBDC | bleomisin · diğer yol | – | Objective: The cell membrane is a major barrier for delivery of hydrophilic drugs and molecules into the cells. Although low voltage and high frequency electric fields (LVHF) are proposed to… |
| Gen ET | Kos · Pharmaceutics | 2021 | İn Vitro Çalışma | Hücre Kültürü | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator, BetaTech | plazmid DNA · intratümöral | – | Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such a… |
| IRE | Graybill et al · Annu Int Conf IEEE Eng Med Biol Soc | 2021 | İn Vitro Çalışma | Hücre Kültürü | Kan-Beyin Bariyeri Geçirgenliğinin Artması | – | – | – | – | Local disruption of the blood-brain barrier (BBB) by pulsed electric fields shows significant potential for treating neurological conditions. Microfluidic BBB models can provide low-cost, co… |
| IRE | Alinezhadbalalami et al · Bioelectrochemistry | 2021 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Expansion of cytotoxic T lymphocytes (CTLs) is a crucial step in almost all cancer immunotherapeutic methods. Current techniques for expansion of tumor-reactive CTLs present major limitation… |
| IRE | Hanson et al · Sci Rep | 2021 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM Square Wave Electroporation System | – | – | Irreversible electroporation (IRE) is used clinically as a focal therapy to ablate solid tumors. A critical disadvantage of IRE as a monotherapy for cancer is the inability of ablating large… |
| IRE | Xu et al · J. Phys.: Conf. Ser. | 2021 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) uses non thermoelectric pulse to ablate tumours, which is an effective cancer treatment method. The pulse is transmitted through a minimally invasive needl… |
| ECT | Fiorentzis et al · J Vis Exp | 2020 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | – | – | bleomisin | – | Electrochemotherapy (ECT) is the combination of transient pore formation following electric pulse application with the administration of cytotoxic drugs, which enhances the cytotoxic effect … |
| Diğer EP | Nathamgari et al · Small | 2020 | İn Vitro Çalışma | Hücre Kültürü | – | – | NFP-E, nanofountain probe electroporation | plazmid DNA | transfeksiyon verimi 70.3% (126 bildirilmemiş) | Introducing exogenous molecules into cells with high efficiency and dosage control is a crucial step in basic research as well as clinical applications. Here, the capability of the nanofount… |
| Diğer EP | Rems et al · Biophys J | 2020 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | – | – | – | – | Pulsed electric fields are increasingly used in medicine to transiently increase the cell membrane permeability via electroporation to deliver therapeutic molecules into the cell. One type o… |
| Kalsiyum EP | Szewczyk et al · Bioelectrochemistry | 2020 | İn Vitro Çalışma | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – | BTX ECM830, BTX Petri Pulser Electrode | kalsiyum klorür | – | Calcium electroporation (CaEP) has been previously reported as an effective method of rhabdomyosarcoma cells reduction. CaEP causes temporary cell membrane permeabilization with simultaneous… |
| Diğer EP | Sözer et al · Biophys J | 2020 | İn Vitro Çalışma | Hücre Kültürü | – | – | FPG 10-10NK, FPG 10-1CN6V2 | diğer | – | Although transport of molecules into cells via electroporation is a common biomedical procedure, its protocols are often based on trial and error. Despite a long history of theoretical effor… |
| Diğer EP | Wolff et al · Cancers (Basel) | 2020 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | – | BTX ECM830, electro square porator | – | – | New approaches in oncotherapy rely on the combination of different treatments to enhance the efficacy of established monotherapies. Pulsed electric fields (PEFs) are an established method (e… |
| ECT | Youssef et al · Mathematics | 2020 | İn Vitro Çalışma | Hücre Kültürü | Termal Etki ve Joule Isınması | – | – | – | – | The essential target of the tumor’s treatment is how to destroy its tissues. This work is dealing with the thermal damage of the tumor tissue due to the thermoelectrical effect based on the … |
| IRE | Lv et al · IEEE Trans Biomed Eng | 2020 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Unlabelled: Irreversible electroporation (IRE) employs brief, high-electric field pulses to ablate tumors while preserving the extracellular matrix. Recently, we showed that combining short … |
| Gen ET | Polajžer et al · Sci Rep | 2020 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | laboratory prototype pulse generator | – | – | Pulsed electric field treatment has increased over the last few decades with successful translation from in vitro studies into different medical treatments like electrochemotherapy, irrevers… |
| IRE | Lv et al · Phys Med Biol | 2020 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) is a minimally invasive tumor therapy using pulsed electric field with high intensity while the important tissues such as blood vessel, bile duct, and nerv… |
| IRE | Polajzer et al · Radiol Oncol | 2020 | İn Vitro Çalışma | Hücre Kültürü | İmmünojenik Hücre Ölümü (ICD), İrreversible Por Oluşumu ve Hücre Ölümü | – | Laboratory prototype pulse generator | – | – | Background Tumor cells can die via immunogenic cell death pathway, in which damage-associated molecular pattern molecules (DAMPs) are released from the cells. These molecules activate cells … |
| ECT | Brun et al · Bioelectrochemistry | 2019 | İn Vitro Çalışma | Hücre Kültürü | Ekstraselüler Matriks ve Doku İskeletinin Korunması | – | Igea EPS-02, EPS-02 | – | – | Electroporation of cells is usually studied using cell suspensions or monolayer cultures. 3D scaffolds for cell culture have been recently designed in order to reproduce in vitro the complex… |
| ECT | García-Sánchez et al · Bioelectrochemistry | 2019 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Doku İletkenliği ve Empedans Değişimi | – | Cliniporator | bleomisin | hücre canlılığı 18% | In this study the evolution in the efficiency of electrochemotherapy (reversible electroporation) with pulse number was assessed in vitro. Experiments were performed using 100 μs pulses at d… |
| Diğer EP | He et al · Nano Lett | 2019 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu | – | – | – | – | Downstream analysis of circulating tumor cells (CTCs) has provided new insights into cancer research. In particular, the detection of CTCs, followed by the regulation and monitoring of their… |
| ECT | Mączyńska et al · Oncol Rep | 2019 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | BTX ECM830, Petri Pulser | sisplatin · diğer yol | – | Betulinic acid (BTA) is naturally occurring triterpene that has received interest as a novel therapeutic substance with cytotoxicity towards a number of cancer cell lines. Despite the wide s… |
| Diğer EP | Ruzgys et al · Sci Rep | 2019 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Transmembran Potansiyel Değişimi | – | – | bleomisin · intratümöral | hücre canlılığı 79% (400 bildirilmemiş) | In this study we evaluated the influence of medium conductivity to propidium iodide (PI) and bleomycin (BLM) electroporation mediated transfer to cells. Inverse dependency between the extrac… |
| Diğer EP | Phonesouk et al · Materials (Basel) | 2019 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | – | electro cell S20 | diğer · diğer yol | – | In the fields of biology and medicine, nanoproducts such as nanoparticles (NPs) are specifically interesting as theranostic tools, since they offer the double capacity to locally deliver act… |
| Diğer EP | Punjiya et al · Sci Rep | 2019 | İn Vitro Çalışma | Hücre Kültürü | Termal Etki ve Joule Isınması | – | – | plazmid DNA · diğer yol | transfeksiyon verimi 80% (100 hasta) | Isolation of cells and their transfection in a controlled manner is an integral step in cell biotechnology. Electric field approaches such as dielectrophoresis (DEP) offers a more viable met… |
| Diğer EP | Tamra et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2019 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu | – | Tektronix AFG3022C | diğer · diğer yol | diğer 98% | In this study, a microwave biosensor based on interdigitated electrode layout is evaluated as an on-chip electroporation system applicable to electroporation of adherent cell monolayers. The… |
| IRE | Ren et al · Int J Hyperthermia | 2019 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Introduction: Irreversible electroporation (IRE) combined with a catheter-based electrode during endoscopy is a potential alternative treatment method for digestive tract tumors. The aim of … |
| Diğer EP | Lu et al · Onco Targets Ther | 2018 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | diğer · diğer yol | – | Background: Pulsed electric field (PEF) has been considered as a cell permeability enhancing agent for cancer treatment. Nevertheless, application of PEF for conventional electrochemo-therap… |
| Diğer EP | Srimathveeravalli et al · Mol Imaging | 2018 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | ECM835 generator | diğer · intravenöz | tümör hacmi değişimi 1.86% (4 hayvan) | Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal… |
| Diğer EP | SUBRAMANI et al · Turk J Elec Eng & Comp Sci | 2018 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu | – | – | – | kanama kontrolü 5.9% | Pulsed electric field technology is an emerging nonthermal food processing method. PEF food processing requires a high voltage pulse generator that produces high intensive pulses to be deliv… |
| Kalsiyum EP | Romeo et al · Technol Cancer Res Treat | 2018 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Darbe Parametrelerinin Optimizasyonu | – | Cliniporator | kalsiyum klorür · diğer yol | – | Reversible electroporation is used to increase the uptake of chemotherapeutic drugs in local tumor treatment (electrochemotherapy) by applying the pulsing protocol (8 rectangular pulses, 100… |
| Diğer EP | García-Sánchez et al · Biosens Bioelectron | 2018 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | – | – | – | This paper reports the comparative analysis, by means of electric impedance spectroscopy measurements, of three different cell lines subjected to electroporative pulses. The multifrequency i… |
| IRE | Yang et al · PLoS One | 2018 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM830 | – | – | Purpose: The aim of this study was to develop a statistical model for cell death by irreversible electroporation (IRE) and to show that the statistic model is more accurate than the electric… |
| Diğer EP | Azan et al · Sci Rep | 2017 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | Cliniporator | – | – | Confocal Raman microspectroscopy was used to study the interaction between pulsed electric fields and live cells from a molecular point of view in a non-invasive and label-free manner. Raman… |
| IRE | Bonakdar et al · RSC Adv | 2017 | İn Vitro Çalışma | Hücre Kültürü | Kan-Beyin Bariyeri Geçirgenliğinin Artması, Reversible Membran Permeabilizasyonu | – | BTX pulse generator, function generator | – | – | Pulsed electric fields interact with the blood-brain barrier (BBB) and have been shown to increase the BBB permeability under some pulsing regimes. Pulsed electric fields may enhance drug de… |
| Diğer EP | Hanna et al · Stem Cell Res Ther | 2017 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | Cliniporator | – | – | Background: Human mesenchymal stem cells are promising tools for regenerative medicine due to their ability to differentiate into many cellular types such as osteocytes, chondrocytes and adi… |
| IRE | Rajeckaitė et al · J Membr Biol | 2017 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – / 28 | BTX Electroporator | – | – | The aim of this study was to investigate the dependence of calcein extraction and cell viability on the parameters of pulsed electric field (PEF). Two different approaches concerning PEF par… |
| Diğer EP | Rezaee et al · Int J Nanomedicine | 2017 | İn Vitro Çalışma | Hücre Kültürü | – | – | Bio-Rad Gene Pulser Xcell | – | hastalıksız sağkalım 2.89 skor | Background and objective: Radiation therapy (RT) is the gold standard treatment for more than half of known tumors. Despite recent improvements in RT efficiency, the side effects of ionizing… |
| IRE | Labarbera · Bioengineering (Basel) | 2017 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | One recent area of cancer research is irreversible electroporation (IRE). Irreversible electroporation is a minimally invasive procedure where needle electrodes are inserted into the body to… |
| IRE | Labarbera et al · Theor Biol Med Model | 2017 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Background: One recent area of cancer research is irreversible electroporation (IRE). Irreversible electroporation is a minimally invasive procedure where needle electrodes are inserted into… |
| Diğer EP | DiGiusto et al · Mol Ther Methods Clin Dev | 2016 | İn Vitro Çalışma | Hücre Kültürü | – | – | MaxCyte GT Transfection System | diğer · diğer yol | diğer 69.6% (138 colonies) | Gene therapy for HIV-1 infection is a promising alternative to lifelong combination antiviral drug treatment. Chemokine receptor 5 (CCR5) is the coreceptor required for R5-tropic HIV-1 infec… |
| Diğer EP | Dovgan et al · J Membr Biol | 2016 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | Jouan GHT 1287 B | – | hücre canlılığı 83.8% | New cryopreservation approaches for medically applicable cells are of great importance in clinical medicine. Current protocols employ the use of dimethyl sulfoxide (DMSO), which is toxic to … |
| ECT | Esmekaya et al · J Membr Biol | 2016 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | BTX square wave pulse generator | sisplatin · intratümöral | hücre canlılığı 66% (3 bildirilmemiş) | Electrochemotherapy is the usage of electroporation to introduce chemotherapeutic drugs through membrane pores into target cells for cancer treatment. The effectiveness of chemotherapeutic d… |
| Diğer EP | Frandsen et al · J Membr Biol | 2016 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | – | BTX T820 square wave electroporator, Cliniporator | – | – | Electroporation-based treatments and other therapies that permeabilize the plasma membrane have been shown to be more devastating to malignant cells than to normal cells. In this study, we a… |
| Diğer EP | Guo et al · Sci Rep | 2016 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | This paper reports a novel microarray chip for in-situ, real-time and selective electroporation on individual cells integrated with cell positioning and impedance monitoring. An array of qua… |
| Diğer EP | Novickij et al · Sci Rep | 2016 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | square wave electroporator | – | – | Electroporation is a phenomenon occurring due to exposure of cells to Pulsed Electric Fields (PEF) which leads to increase of membrane permeability. Electroporation is used in medicine, biot… |
| Diğer EP | Tamošiūnas et al · J Membr Biol | 2016 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intratümöral | – | In this study, we aimed to determine whether the combination of electroporation (EP) and ultrasound (US) waves (sonoporation) can result in an increased intracellular delivery of anticancer … |
| Kalsiyum EP | Zielichowska et al · Bioelectrochemistry | 2016 | İn Vitro Çalışma | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – | BTX ECM830 | kalsiyum klorür | – | The electroporation (EP) supports various types of anticancer therapies by the selective transport of cytostatics. Increase in intracellular calcium level by EP may be a new approach to fibr… |
| Gen ET | Lesueur et al · Mol Ther Nucleic Acids | 2016 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator | plazmid DNA · diğer yol | – | Gene electrotransfer is a safe and efficient nonviral technique for the transfer of nucleic acids of all sizes. Using a small reporter plasmid (3.5 kbp), electrotransfer of more than 90% of … |
| Diğer EP | Pasquet et al · Biochem Biophys Rep | 2016 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | electrocell S20 | plazmid DNA | – | Electric field mediated gene transfer is facing a problem in expression yield due to the poor transfer across the nuclear envelope. Trans-cyclohexane-1,2-diol (TCHD) was shown to significant… |
| Gen ET | Denzi et al · J Membr Biol | 2016 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Over the past decades, the effects of ultrashort-pulsed electric fields have been used to investigate their action in many medical applications (e.g. cancer, gene electrotransfer, drug deliv… |
| IRE | Bonakdar et al · Biophys J | 2016 | İn Vitro Çalışma | Hayvan (İn Vivo) | Kan-Beyin Bariyeri Geçirgenliğinin Artması, Reversible Membran Permeabilizasyonu | – | BTX pulse generator | – | – | The blood-brain barrier, mainly composed of brain microvascular endothelial cells, poses an obstacle to drug delivery to the brain. Controlled permeabilization of the constituent brain endot… |
| ECT | Landström et al · Anticancer Res | 2015 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Gene Pulser Xcell | bleomisin · diğer yol | – | Aim: Electrochemotherapy (ECT) is a new cancer treatment modality that uses electroporation to potentiate chemotherapeutic agents, especially bleomycin. ECT causes both a direct toxic effect… |
| Gen ET | Madi et al · J Membr Biol | 2015 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | electro cell S20 | diğer · topikal | – | DNA electrotransfer is a successful technic for gene delivery. However, its use in clinical applications is limited since little is known about the mechanisms governing DNA electrotransfer i… |
| ECT | Zielichowska et al · Biomed Pharmacother | 2015 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM830 | – | – | Introduction: Electroporation (EP) is commonly applied for effective drug transport thorough cell membranes based on the application of electromagnetic field. When applied with cytostatics, … |
| Diğer EP | Lojk et al · Bioelectromagnetics | 2015 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – | Jouan GHT 1287B generator | diğer | – | Introduction of genetic material into muscle tissue has been extensively researched, including isolation and in vitro expansion of primary myoblasts as a potential source of cells for skelet… |
| Kalsiyum EP | Frandsen et al · Biochim Biophys Acta | 2014 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | – | BTX T820 square wave electroporator | bleomisin | – | Background: Electroporation with calcium (calcium electroporation) can induce ATP depletion-associated cellular death. In the clinical setting, the cytotoxic drug bleomycin is currently used… |
| Gen ET | Garcia et al · PLoS One | 2014 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | NanoKnife | – | – | Electroporation-based therapies are powerful biotechnological tools for enhancing the delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs). Electrochemotherapy … |
| Diğer EP | Lekner · Phys Med Biol | 2014 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation in cancer therapy in which elongated micron-sized conductors are used to enhance an externally applied electric field is investigated. Such field enhancement was previously u… |
| ECT | Meulenberg et al · Toxicol In Vitro | 2014 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | – | homemade electroporator | bleomisin | – | The aim of this study was to develop an in vitro cell model for studying the in vivo observed vascular effect, induced by exposing blood vessels to changing electric field strengths. Human m… |
| ECT | Ramachandran et al · Electroporation-Based Therapies for Cancer | 2014 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | BTX ECM830 | bleomisin | – | Cancer therapies mainly target the uncontrolled proliferation of the cancerous cells. A translational therapy for inoperable, chemo- and radio-resistant tumors is electroporationbased chemot… |
| Diğer EP | Rangel et al · J Membr Biol | 2014 | İn Vitro Çalışma | Hücre Kültürü | – | – | BTX apparatus 830, Petri pulser BTX | – | – | Connexins are proteins that form gap junctions. Perturbations in the cell membrane reportedly promote changes in the expression profile of connexins. Electroporation promotes destabilization… |
| Diğer EP | Reigada · Biochim Biophys Acta | 2014 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Electroporation is the basis for the transfection of genetic material and for drug delivery to cells, including electrochemotherapy for cancer. By means of molecular dynamics many aspects of… |
| Gen ET | Guo et al · Mol Ther Methods Clin Dev | 2014 | İn Vitro Çalışma | Hücre Kültürü | Nanosaniye Darbeli Elektrik Alan (nsPEF), Gen Elektrotransferi (Plazmid DNA) | – | BTX ECM830, custom-designed nanosecond pulse generator | plazmid DNA | – | The impact of nanosecond pulsed electric fields (nsPEFs) on gene electrotransfer has not been clearly demonstrated in previous studies. This study was conducted to evaluate the influence of … |
| IRE | Colacino et al · Technol Cancer Res Treat | 2014 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | hücre canlılığı 70% | Cellulose nanocrystals are rod-shaped, crystalline nanoparticles that have shown prom-ise in a number of industrial applications for their unique chemical and physical properties. However, i… |
| ECT | Bagheri et al · J Biomed Phys Eng | 2013 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Antivasküler Etki ve Damar Yıkımı | – | ECT-SBDC | bleomisin | – | Unlabelled: Propose: Standard electroporation and electrochemotherapy caused the endothelial cell permeability and reduction in tumor blood flow. The effects of low voltage and high frequenc… |
| ECT | Gibot et al · J Control Release | 2013 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | CNRS Cell Electropulsator | bleomisin | – | Electrochemotherapy (ECT) is a physical technique that allows cytotoxic molecules to be efficiently released in tumor cells by inducing transient cell plasma membrane permeabilization. The m… |
| IRE | Korohoda · Cell Mol Biol Lett | 2013 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Experiments on reversible and irreversible cell electroporation were carried out with an experimental setup based on a standard apparatus for horizontal electrophoresis, a syringe pump with … |
| ECT | Mansourian et al · Electromagn Biol Med | 2013 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Apoptoz İndüksiyonu | – | ECT-SBDC | bleomisin · intratümöral | progresyonsuz sağkalım 160% | Nowadays, due to the wide use of mobile phones, extensive studies have been carried out on the effects of magnetic field (MF) on public health. In this paper, we study the effect of 217 Hz M… |
| ECT | Shankayi et al · J Membr Biol | 2013 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – | ECT-SBDC | bleomisin | – | During standard electrochemotherapy (ECT), using a train of 1,000 V/cm amplitude rectangular pulses with 1 Hz frequency, patients experience an unpleasant sensation and slight edema. Accordi… |
| Gen ET | Liew et al · Hum Gene Ther Methods | 2013 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | Cliniporator | plazmid DNA | – | Mesenchymal stem cells (MSCs) are multipotent nonhematopoietic cells with the ability to differentiate into various specific cell types, thus holding great promise for regenerative medicine.… |
| Gen ET | Tesic et al · J Membr Biol | 2013 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | home made electroporator | plazmid DNA · intratümöral | – | Development of recombinant DNA technologies has allowed us to create new delivery systems that target specific cell types and that can be used in gene therapy. One of these targets is vascul… |
| Diğer EP | García-Sánchez et al · Instrumentation viewpoint | 2013 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | – | – | – | Electroporation or electropermeabilization is a phenomenon observed when lipid bilayers, generally cell membranes, are exposed to high electric field pulses becoming transiently permeable to… |
| Diğer EP | Delemotte et al · J Membr Biol | 2012 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | The permeability of cell membranes can be transiently increased following the application of external electric fields. Theoretical approaches such as molecular modeling provide a significant… |
| ECT | Ghiasi et al · Int J Biomed Sci | 2012 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin · intratümöral | tam yanıt 40% (30 hayvan) | The Electrochemotherapy (ECT) is an effective treatment of cutaneous and subcutaneous solid tumors. Electric field is applied to tumor nodules to enhance the delivery/distribution of a non-p… |
| IRE | Kaminska et al · Gen Physiol Biophys | 2012 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | hücre canlılığı 50% | Application of a high electric field causes an electric shock to the heart. This is utilized in defibrillation to reestablish normal contraction rhythms during dangerous arrhythmias or in ca… |
| Diğer EP | Raeisi et al · J Membr Biol | 2012 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | Cliniporator | bleomisin | – | This study investigated whether molecules spontaneously transported inside cells, like glucose derivatives, can also be used as electropermeabilization markers. Uptake of a fluorescent deoxy… |
| Diğer EP | Towhidi et al · Radiol Oncol | 2012 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu | – | Cliniporator | – | – | Background: The cell membrane acts as a barrier that hinders free entrance of most hydrophilic molecules into the cell. Due to numerous applications in medicine, biology and biotechnology, t… |
| Diğer EP | Chabot et al · Mol Ther | 2012 | İn Vitro Çalışma | Hücre Kültürü | – | – | S20u electropulsator | diğer | – | Micro-RNAs (miRNAs) are small regulatory RNAs that play an important role in disease development and progression and therefore represent a potential new class of therapeutic targets. However… |
| Belirlenmedi | Chopinet et al · Int J Pharm | 2012 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | – | CNRS cell electropulsator | bleomisin | – | Electro-gene-therapy is a promising technique for cancer treatment. However, knowledge about mechanism of gene transfer with electric field in tumor is limited. Whereas in vitro electrotrans… |
| Diğer EP | Okeyo et al · The Proceedings of the Symposium on Micro-Nano Science and Technology | 2012 | İn Vitro Çalışma | Hücre Kültürü | – | – | – | – · diğer yol | transfeksiyon verimi 5% | An electroporation device comprising an orifice sheet with regularly spaced micron size orifices for electric field constriction was developed and utilized to electropolate adherent HeLa cel… |
| IRE | Arena et al · Biophys J | 2012 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) is emerging as a powerful tool for tumor ablation that utilizes pulsed electric fields to destabilize the plasma membrane of cancer cells past the point of… |
| IRE | Xiong et al · J Cancer Res Ther | 2012 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | electric pulses therapeutic system | – | hücre canlılığı 62.25% | Background: High-voltage electric field pulses can make cell membrane electroporated irreversibly and eliminate malignant cells via necrosis. However, low-voltage is not efficient as that. A… |
| Diğer EP | Pakhomova · PLoS One | 2011 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | – | AVTECH AVOZ-D2-B-ODA pulser | – | – | Background: Electroporation is a method of disrupting the integrity of cell membrane by electric pulses (EPs). Electrical modeling is widely employed to explain and study electroporation, bu… |
| Diğer EP | Skolucka et al · Asian Pac J Trop Biomed | 2011 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres | – | BTX ECM830 | – | – | Objective: To estimate electroporation (EP) influence on malignant and normal cells. Methods: Two cell lines including human malignant melanoma (Me-45) and normal human gingival fibroblast (… |
| Diğer EP | Troszak et al · PLoS One | 2011 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electroporation, the permeabilization of the cell membrane lipid bilayer due to a pulsed electric field, has important implications in the biotechnology, medicine, and food industries. Tradi… |
| Diğer EP | Joergensen et al · Oligonucleotides | 2011 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Darbe Parametrelerinin Optimizasyonu | – | Cliniporator, Cellaxess CX3 | – | – | Electroporation is potentially a very powerful technique for both in vitro cellular and in vivo drug delivery, particularly relating to oligonucleotides and their analogs for genetic therapy… |
| ECT | Lambreva et al · Bioelectrochemistry | 2010 | İn Vitro Çalışma | Hücre Kültürü | – | – | BTX Electro Cell Manipulator-600 | diğer | hücre canlılığı 8% | Two reliable methods have been combined: i) the electroporation of the cell membranes for facilitating the sensitizer incorporation into hystiocytic human lymphoma cells U-937 and (ii) the p… |
| IRE | Golberg et al · Biomed Eng Online | 2010 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Background: Irreversible electroporation (IRE) is a minimally invasive tissue ablation technique which utilizes electric pulses delivered by electrodes to a targeted area of tissue to produc… |
| ECT | Choi et al · Anal Chem | 2009 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | – | – | – · diğer yol | – | A microfabricated cell-based testing device for electrochemotherapy (ECT) has been developed; it mimics a clinical electroporator with a circular needle array and maintains a similar electri… |
| Diğer EP | Golzio et al · Biophysical Journal | 2009 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | – | – | – | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Labanauskienė et al · Medicina | 2009 | İn Vitro Çalışma | Hücre Kültürü | – | – | high intensity impulse generator | diğer · diğer yol | – | The aim of our study was to determine if electroporation could improve the efficacy of photodynamic tumor therapy. A disadvantage of photodynamic therapy is a slow and in some cases insuffic… |
| ECT | Tabassum et al · Spectrochim Acta A Mol Biomol Spectrosc | 2009 | İn Vitro Çalışma | Hücre Kültürü | – | – | – | – | genel sağkalım 0 diğer | The homodinuclear C(16)H(30)N(8)O(5)Sn(2)Cl(4) (1), heterotetranuclear C(16)H(38)N(8)O(9)Sn(2)Cu(2)Cl(8) (2) and C(16)H(38)N(8)O(9)Sn(2)Mn(2)Cl(8) (3) macrocyclic complexes were synthesized … |
| Diğer EP | Ušaj et al · Radiology and Oncology | 2009 | İn Vitro Çalışma | Hücre Kültürü | – | – | Cliniporator | – | hücre canlılığı 63% | Cell size dynamics and viability of cells exposed to hypotonic treatment and electroporation for electrofusion optimizationBackground. Various electrofusion parameters have to be adjusted to… |
| Gen ET | Wasungu et al · Int J Pharm | 2009 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | CNRS cell electropulsator, CNRS cell electropulsator (Jouan) | – | – | Electropermeabilization is a physical method to deliver molecules into cells and tissues. Clinical applications have been successfully developed for antitumoral drug delivery and clinical tr… |
| IRE | Shafiee et al · J Biomech Eng | 2009 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | – | BTX electroporator | – | – | Intense but short electrical fields can increase the permeability of the cell membrane in a process referred to as electroporation. Reversible electroporation has become an important tool in… |
| Diğer EP | Böckmann et al · Biophys J | 2008 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Membrane electroporation is the method to directly transfer bioactive substances such as drugs and genes into living cells, as well as preceding electrofusion. Although much information on t… |
| Diğer EP | He et al · Bioelectrochemistry | 2008 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Doku İletkenliği ve Empedans Değişimi | – | – | – | – | This paper presents a novel method to measure the dynamic process of membrane permeability during electroporation (EP) on microchips for human cancer cells. Micro EP chips with three-dimensi… |
| Diğer EP | Kandušer et al · Bioelectrochemistry | 2008 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | Cliniporator | bleomisin · intratümöral | kanama kontrolü 80% (400 örnek) | Cell membrane permeabilization is caused by the application of high intensity electric pulses of short duration. The extent of cell membrane permeabilization depends on electric pulse parame… |
| ECT | Choi et al · Biomed Microdevices | 2008 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi, Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin | – | A microfabricated cell-based testing device for electrochemotherapy (ECT) has been developed by miniaturizing the widely used clinical electroporator with a two-needle array into two-dimensi… |
| Diğer EP | Koda et al · Langmuir | 2008 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | Gene Pulser Xcell | plazmid DNA · diğer yol | – | Gene transfection into adherent cells from plasmid DNA (pDNA)-arrayed substrates known as gene transfection arrays appears to be a promising tool for the high-throughput analysis of gene fun… |
| Diğer EP | MacQueen et al · Bioelectrochemistry | 2008 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi, Darbe Parametrelerinin Optimizasyonu | – | – | plazmid DNA · diğer yol | – | We report the use of dielectrophoresis (DEP) to position U-937 monocytes within a non-uniform electric field, prior to electroporation (EP) for gene delivery. DEP positioning and EP pulsing … |
| Diğer EP | Anon · Molecular Therapy | 2007 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | – | bleomisin | – | Ultrasound-mediatedtransient membrane poration or sonoporation represents a promising means of non-invasively achieving targeted gene transfer in vivo. Sonoporation events are enhanced by th… |
| Diğer EP | Bicek et al · Bioelectrochemistry | 2007 | İn Vitro Çalışma | Hücre Kültürü | – | – | Cliniporator | diğer · diğer yol | hücre canlılığı 90% | Ruthenium complex NAMI-A [ImH][trans-RuCl(4)(DMSO-S)Im] (Im = imidazole) is a potential chemotherapeutic drug in cancer treatment. Electroporation can be used to facilitate delivery of NAMI-… |
| Diğer EP | Pavlin et al · Biochim Biophys Acta | 2007 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | – | prototype developed at the University of Ljubljana, Faculty, Cliniporator | – | – | Electroporation is a process where increased permeability of cells exposed to an electric field is observed. It is used in many biomedical applications including electrogene transfection and… |
| Diğer EP | Pliquett et al · IEEE Trans Biomed Eng | 2007 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrot Geometrisi ve Yerleşimi | 2 | homemade pulser | diğer · topikal | – | Electrical creation of aqueous pathways across the skin's outer layer [stratum corneum (SC)] provides an approach to transdermal delivery of medium-size water-soluble compounds. However, ner… |
| Diğer EP | Pucihar et al · Eur Biophys J | 2007 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | – | Jouan electropulsator | – | – | This paper investigates the influence of cell density on cell membrane electropermeabilization. The experiments were performed on dense cell suspensions (up to 400 x 10(6) cells/ml), which r… |
| Diğer EP | Xu et al · Bioelectrochemistry | 2007 | İn Vitro Çalışma | Hücre Kültürü | – | – | Bio-Rad Gene Pulser Xcell | – | hücre canlılığı 0% | In this paper, it was reported for the first time that the combination of the electroporation and the conjugation of the TiO(2) nanoparticles with the monoclonal antibody could improve the p… |
| Gen ET | Čorović et al · Biomed Eng Online | 2007 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Background: Electrochemotherapy and gene electrotransfer are novel promising treatments employing locally applied high electric pulses to introduce chemotherapeutic drugs into tumor cells or… |
| Gen ET | Reberšek et al · Biomed Eng Online | 2007 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | – | EP-GMS 7.1 | – · diğer yol | transfeksiyon verimi 24% | Background: Gene electrotransfer is a non-viral method used to transfer genes into living cells by means of high-voltage electric pulses. An exposure of a cell to an adequate amplitude and d… |
| Diğer EP | Kanthou et al · Mol Cancer Ther | 2006 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | – | EquiBio in situ electroporation cuvette system | – | – | Electroporation-based therapies, such as electrochemotherapy and electrogene therapy, result in the disruption of blood vessel networks in vivo and cause changes in blood flow and vascular p… |
| Diğer EP | Lu et al · Biosens Bioelectron | 2006 | İn Vitro Çalışma | Hücre Kültürü | Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Microfabricated devices for cell lysis have demonstrated many advantages over conventional approaches. Among various design of microdevices that employ electroporation for cytolysis, most ut… |
| Diğer EP | Pavlin et al · Biophys J | 2005 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi | – | prototype developed at the Laboratory of Biocybernetics, Fac | bleomisin · intratümöral | – | An increased permeability of a cell membrane during the application of high-voltage pulses results in increased transmembrane transport of molecules that otherwise cannot enter the cell. Inc… |
| IRE | Miller et al · Technol Cancer Res Treat | 2005 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | hücre canlılığı 0% | In this study we perform in vitro irreversible electroporation (IRE) experiments with human hepatocarcinoma cells (HepG2) to investigate IRE as a new technique for undesirable tissue ablatio… |
| Diğer EP | Pavlin et al · Biophys J | 2003 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | – | – | – | During the electroporation cell membrane undergoes structural changes, which increase the membrane conductivity and consequently lead to a change in effective conductivity of a cell suspensi… |
| Gen ET | Cemazar et al · DNA Cell Biol | 2003 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Sisplatin Hücre İçi Birikiminin Artması | – | Jouan GHT 1287 electroporator, GT-1 electroporator | – · intravenöz | tümör hacmi değişimi 75% | The aim of our study was to evaluate electrogenetherapy with p53wt alone or combined with cisplatin on two colorectal (HT-29 and LoVo) and two prostatic (PC-3 and Du145) carcinoma cell lines… |
| Diğer EP | Krassowska et al · Ann Biomed Eng | 2003 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin | – | The goal of this study was to collect a comprehensive set of data that related lethal effects of electric fields to the duration of the pulse. Electric pulses of different strengths and dura… |
| ECT | Pucihar et al · Bioelectrochemistry | 2002 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | custom-built electropulsator | diğer | – | Electrochemotherapy is a technique where electric pulses in combination with chemotherapeutic agents are applied to tumor cells. In general, patients find electrochemotherapy tolerable, in s… |
| ECT | Jaroszeski et al · Anticancer Drugs | 2000 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | BTX T820 DC generator | bleomisin | – | Electroporation is a physical event that temporarily reduces cell membrane barrier properties. Diminished membrane barrier properties are achieved by exposing cells to pulsed electric fields… |
| Diğer EP | Zewert et al · Bioelectrochem Bioenerg | 1999 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | A combined electrical (HV, "high voltage", pulsing) and chemical (topical sodium thiosulfate) intervention is hypothesized to create enlarged aqueous pathways that allow large quantities of … |
| Diğer EP | Lebar et al · Electro- and Magnetobiology | 1998 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Jouan GHT 1287 | – | – | The effect of applied electrical energy on cell survival and permeabi-lization of the plasma membrane under in vitro conditions were examined. Cell viability was measured with a colony-formi… |
| Diğer EP | Ĉemazˆr et al · Electro- and Magnetobiology | 1998 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | – | – | – | – | Electropermeabilization (electroporation) is a technique widely used to introduce various membrane-impermeable molecules into cells in vitro or in vivo. In this study we determined the effec… |
| ECT | Jaroszeski et al · Adv Drug Deliv Rev | 1997 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 6 / 18 | – | bleomisin | – | The combined treatment consisting of a chemotherapeutic agent and pulsed electric fields has been termed electrochemotherapy. This relatively new treatment modality relies on the physical ef… |
| Diğer EP | T Kalinski, K Jaquet, R Langen, L Wang, H Gabbert, C Gerharz · Biotechnology Techniques | 1997 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | – | Gene Pulser | – | transfeksiyon verimi 25% | Transfection as a method for the introduction of nucleic acids into eukaryotic cells is an important tool for functional investigations of genes not expressed or mutated in target cells. Sev… |
| Diğer EP | Anon · Progress in Biophysics and Molecular Biology | 1996 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi | – | – | – | – | C 1 Transmembrane signalling and transduction P-cl45 P-Cl-46 REGULATORY ROLE OF THE MBMBRANE POTENTIAL ON THE ACTIVATION STRUCTURAL AND ELECTRICAL PROPERTIES OF SUPPORTED LIPID FILMS BY IMPE… |
| Diğer EP | Pliquett et al · Bioelectrochemistry and Bioenergetics | 1996 | İn Vitro Çalışma | Hücre Kültürü | – | – | ECM 600, Gene Pulser | – | – | The stratum comeum (SC) of mammalian skin is a formidable barrier to the transport of both small ions and charged molecules, but large, very rapid increases in transport can be created by "h… |
| Diğer EP | Sharma et al · Biophys J | 1996 | İn Vitro Çalışma | Hücre Kültürü | Transmembran Potansiyel Değişimi | – | – | – | lokal kontrol 423.4 mm (10 örnek) | The effect of a nontoxic, nonionic block co-polymeric surface active agent, poloxamer 188, on electroporation of artificial lipid membranes made of azolectin, was investigated. Two different… |
| ECT | Mir et al · Bioelectrochemistry and Bioenergetics | 1995 | İn Vitro Çalışma | Hücre Kültürü | – | – | – | bleomisin · intravenöz | nesnel yanıt 50% | Short and intense electric pulses (EP) are regularly used in almost all molecular and cellular biology laboratories to introduce foreign DNA, as well as other exogeneous molecules, into livi… |
| Diğer EP | Prausnitz et al · Biophys J | 1995 | İn Vitro Çalışma | Hücre Kültürü | – | – | Gene Pulser | diğer | tam yanıt 0% (97 bildirilmemiş) | Electroporation involves the application of an electric field pulse that creates transient aqueous pathways in lipid bilayer membranes. Transport through these pathways can occur by differen… |
| Diğer EP | Vanbever et al · Bioelectrochemistry and Bioenergetics | 1995 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Easyject Plus | diğer · topikal | – | Electroporation, i.e. the creation of transient enhanced lipid membrane permeability using high intensity electric field pulses, can be used to promote transdermal drug delivery. Compared wi… |
| Diğer EP | Lopes et al · IEEE Trans. Instrum. Meas. | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electroporation (EP)–based cancer therapies, such as electrochemotherapy (ECT) and irreversible electroporation (IRE), require accurate characterization of tissue electrical properties to pr… |
| ECT | Borbála Fülöp et al · J Theor Biol | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Electroporation-based therapies such as electrochemotherapy (ECT) hold a great promise for improving cancer treatments. While highly effective for superficial tumours, its application for de… |
| Diğer EP | Leschiera et al · Bioelectrochemistry | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | İmmünojenik Hücre Ölümü (ICD) | – | Electrocell S20, Electrocell S20 generator | – | – | Electroporation is increasingly used as a percutaneous ablation technique for tumours located near vital structures. Although effective, tumour regrowth may still occur. At the same time, in… |
| ECT | Vélez Salazar et al · Front Bioinform | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Vasküler Kilit (Vascular Lock) Etkisi | – | – | – | – | Drug administration via the bloodstream involves some transport and reaction mechanisms ( R T M s ), such as extravasation, perfusion along blood vessels, transmembrane and interstitial tran… |
| ECT | Bernardini et al · COMPEL - The international journal for computation and mathematics in electrical and electronic engineering | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Purpose This study aims to present a numerical model to predict the electric field distribution in the presence of conductive or dielectric nanoparticles close to the cell membrane during el… |
| IRE | Chen et al · IEEE Trans Biomed Eng | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | – | – | – | Objective: Asymmetric pulse waveforms represent an optimized treatment protocol for high-frequency irreversible electroporation (H-FIRE), offering a lower ablation threshold compared to symm… |
| IRE | Cheng et al · Ann Biomed Eng | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Doku İletkenliği ve Empedans Değişimi | – | custom-built pulse generator | – | ablasyon hacmi 2 mm | Irreversible electroporation (IRE) is a minimally invasive, non-thermal, and cell-selective technique. When combined with the noninvasive nature of contact electrodes, they hold great promis… |
| IRE | Desier et al · Comput Methods Programs Biomed | 2026 | İn Siliko / Modelleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 15 / 15 | – | – | – | Objective: Irreversible electroporation (IRE) represents a promising non-thermal ablation modality for the treatment of deep-seated tumors. However, its clinical efficacy is critically depen… |
| IRE | Hossain · – | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Bu yayında özet bulunmuyor. |
| IRE | Jordan-Diaz et al · 2026 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Irreversible electroporation (IRE) is a non-thermal ablation technique used for the treatment of soft tissue tumors when thermal ablation is not feasible. Treatment outcome depends on tissue… |
| ECT | Salazar et al · Comput Biol Med | 2025 | İn Siliko / Modelleme | Hesaplamalı Model | Vasküler Kilit (Vascular Lock) Etkisi | – | – | diğer · intravenöz | – | The systemic administration of chemotherapeutic drugs involves some reaction and transport mechanisms (RTMs), including perfusion along the blood vessels, extravasation, lymphatic drainage, … |
| ECT | Skorupska et al · Biosens Bioelectron | 2025 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | We describe a novel lab-on-a-chip microsystem for cells electroporation, which can be used in studies comparing the effectiveness of two anti-cancer procedures. Our device in which we can si… |
| ECT | Vélez · PLoS One | 2025 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | diğer | – | Using in-house computational tools, this work focuses on investigating how the combination of the electric field magnitude (E), bloodstream velocity (λinl) and pharmaco-kinetic profile (PK) … |
| IRE | Matkulcik et al · Int J Hyperthermia | 2025 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Background: Intraluminal irreversible electroporation (IRE) can be used for recanalizing occluded metal stents. However, optimal IRE parameters for consistent effects across different stent … |
| PFA | Batista Napotnik et al · Sci Rep | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Kalsiyum Homeostazının Bozulması, Reversible Membran Permeabilizasyonu | – | laboratory prototype pulse generator | – | transfeksiyon verimi 85% (1 bildirilmemiş) | Electric pulses used in electroporation-based treatments have been shown to affect the excitability of muscle and neuronal cells. However, understanding the interplay between electroporation… |
| Diğer EP | Fang et al · IEEE Trans. Instrum. Meas. | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | BTX ECM830 | – | – | Radiofrequency ablation (RFA) is an energy-based tumor ablation modality that heats tissues by delivering radiofrequency current. The tissue properties of both electrical and thermal conduct… |
| Kalsiyum EP | Jacobs IV et al · Bioelectrochemistry | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Termal Etki ve Joule Isınması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | – | – | kalsiyum klorür · topikal | – | The relationships between burst number, reversible, irreversible, and calcium electroporation have not been comprehensively evaluated in tumor tissue-mimics. Our findings indicate that elect… |
| Diğer EP | Kougkolos et al · J Control Release | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | ELECTRO cell B10 HVLV | diğer · topikal | – | Skin electroporation for drug delivery involves the application of Pulsed Electric Fields (PEFs) on the skin to disrupt its barrier function in a temporary and non-invasive manner, increasin… |
| Diğer EP | Baker et al · IEEE Trans Biomed Eng | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | – | – | – | – | – | Self-consistent evaluations of membrane electroporation along with local heating in single spherical cells arising from external AC radiofrequency electrical stimulation have been carried ou… |
| Diğer EP | He · Gels | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | – | – | – | – | – | Silicone gel, used in the packaging of high-voltage, high-power semiconductor devices, generates bubbles during the packaging process, which accelerates the degradation of its insulation pro… |
| Diğer EP | Liu et al · IEEE Trans. Dielect. Electr. Insul. | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | diğer · diğer yol | – | In the field of biomedicine, electroporation-mediated intracellular drug delivery is becoming increasingly popular due to its high efficiency and accuracy. In order to assess the therapeutic… |
| Diğer EP | Liu et al · IEEE Trans. Dielect. Electr. Insul. | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Doku İletkenliği ve Empedans Değişimi | – | – | – | – | In the study of electroporation, the conductivity of the cell membrane is a crucial factor in assessing the permeability of cell membrane. In previous research, the oversimplified equivalent… |
| Diğer EP | Paffi et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin | – | Purpose of this work is to develop a tool for electrochemotherapy treatment planning, which automatically estimates the optimal electrode configuration on the basis of the calculation of the… |
| Diğer EP | Zhang et al · Bioelectrochemistry | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Nanosaniye Darbeli Elektrik Alan (nsPEF) | – | – | – | – | Electroporation (EP) of the normal cell and cancer cell both in single-cell and multicellular models was investigated by the meshed transport network method (MTNM) in this paper. The simulat… |
| Diğer EP | Lv et al · Journal of Applied Physics | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | – | – | – | bleomisin | – | Electroporation technique induced by high-voltage pulses has been successfully used to ablate tumor cells while preserving the function of normal blood vessels. Generally, the tumor blood ve… |
| IRE | Fesmire et al · IEEE Trans Biomed Eng | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Objective: This study sought to investigate a novel strategy using temperature-controlled delivery of nanosecond pulsed electric fields as an alternative to the 50-100 microsecond pulses use… |
| IRE | González-Suárez et al · Biomed Eng Lett | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | CUTIS, ePORE | – | – | Purpose: Pulsed electrical field (PEF) ablation is an energy-based technique used to treat a range of cancers by irreversible electroporation (IRE). Our objective was to use computational an… |
| IRE | Lakshmi Narasimhan et al · Applied Mathematical Modelling | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | – | – | – | In this paper, we develop surrogate models that can replace expensive predictive models and account for uncertainties in real-time treatment planning for irreversible electroporation of live… |
| ECT | Fülöp et al · – | 2023 | İn Siliko / Modelleme | Hesaplamalı Model | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Electrophoresis facilitated cancer treatment has demonstrated experimental efficacy in enhancing drug delivery within vascularised tumours. However, the lack of realistic mathematical models… |
| PFA | Scuderi et al · Biomolecules | 2023 | İn Siliko / Modelleme | Hesaplamalı Model | Darbe Parametrelerinin Optimizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electroporation is a biophysical phenomenon involving an increase in cell membrane permeability to molecules after a high-pulsed electric field is applied to the tissue. Currently, electropo… |
| ECT | Salazar et al · Med Biol Eng Comput | 2023 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Vasküler Kilit (Vascular Lock) Etkisi | – | – | diğer | – | Reversible electroporation is a suitable technique to aid the internalization of medicaments in cancer tissues without inducing permanent cellular damage, allowing the enhancement of cytotox… |
| Diğer EP | Gabay et al · Ann Biomed Eng | 2023 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | 10 / 10 | – | bleomisin · intravenöz | – | Molecular sampling with vacuum-assisted tissue electroporation is a novel, minimally invasive method for molecular profiling of solid lesions. In this paper, we report on the design of the b… |
| IRE | Perera-Bel et al · IEEE Trans Biomed Eng | 2023 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – / 4 | PIRET | – | – | Unlabelled: Tissue electroporation is the basis of several therapies. Electroporation is performed by briefly exposing tissues to high electric fields. It is generally accepted that electrop… |
| IRE | Lakshmi Narasimhan et al · Med Phys | 2023 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Background: Electroporation-based cancer treatments are minimally invasive, nonthermal interventional techniques that leverage cell permeabilization to ablate the target tumor. However, the … |
| Diğer EP | Vale et al · J. Microw. Optoelectron. Electromagn. Appl. | 2022 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | This study presents a rigorous numerical analysis of the current in the cell membrane, subjected to a uniform electric field, and its impact in the pore formation. The numerical model consid… |
| ECT | Vélez Salazar et al · Computers & Mathematics with Applications | 2022 | İn Siliko / Modelleme | Hesaplamalı Model | Sisplatin Hücre İçi Birikiminin Artması | – | – | diğer | – | Electroporation has become an important technique in cancer treatment to induce the drug internalization into cells by applying controlled electric pulses. In the present work, the simulatio… |
| Gen ET | Potočnik et al · Applied Sciences | 2022 | İn Siliko / Modelleme | Hesaplamalı Model | Darbe Parametrelerinin Optimizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | CellFX System, L-POR, laboratory prototype pulse generator | plazmid DNA | – | Gene electrotransfer (GET) is a widely used method for nucleic acids’ delivery into cells. We explored, evaluated, and demonstrated the potential use of different pulse durations for introdu… |
| IRE | Perera-Bel et al · IEEE Trans Biomed Eng | 2022 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Objective: Irreversible electroporation (IRE) is a non-thermal tissue ablation therapy which is induced by applying high voltage waveforms across electrode pairs. When multiple electrode pai… |
| Diğer EP | E Sabri · – | 2022 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Bu yayında özet bulunmuyor. |
| IRE | Khorasani · Electromagn Biol Med | 2022 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | The primary purpose of cancer treatment with irreversible electroporation (IRE) is to maximize tumor damage and minimize surrounding healthy tissue damage. Finite element analysis is one of … |
| Gen ET | Marino et al · Sci Rep | 2021 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Electroporation (EP), the increase of cell membrane permeability due to the application of electric pulses, is a universal phenomenon with a broad range of applications. In medicine, some of… |
| ECT | Goldberg et al · Bioelectrochemistry | 2021 | İn Siliko / Modelleme | Hesaplamalı Model | Sisplatin Hücre İçi Birikiminin Artması | – | – | sisplatin | – | The use of electrochemotherapy (ECT) is a well-established technique to increase the cellular uptake of cytotoxic agents within certain cancer treatment strategies. The study of the mechanis… |
| Diğer EP | Khorasani · fbt | 2021 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Purpose: In the electroporation we can use different electrode types such as needle and plate electrode with different arrangements. One of the new electrode types is single bipolar electrod… |
| IRE | Aycock et al · IEEE Trans Biomed Eng | 2021 | İn Siliko / Modelleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Unlabelled: High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay (d 1 )-negative phas… |
| Kalsiyum EP | Navickaite et al · Pharmaceutics | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | – | BTX T820 electroporator, high voltage pulse generator | – | – | Electroporation-a transient electric-field-induced increase in cell membrane permeability-can be used to facilitate the delivery of anticancer drugs for antitumour electrochemotherapy. In re… |
| Diğer EP | Chiapperino et al · IEEE Trans Biomed Eng | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – / 3 | Electro cell B10, BetaTech | kalsiyum klorür · diğer yol | hücre canlılığı 2 adet (3 lezyon) | In this article, the reversible electroporation induced by rectangular long unipolar and short bipolar voltage pulses on 3D cells is studied. The cell geometry was reconstructed from 3D imag… |
| IRE | Zhao et al · Applied Physics Letters | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Cell death mediated by non-thermal mechanisms is an essential characteristic of irreversible electroporation for tumor ablation. However, needle electrodes inherently promote thermal damage … |
| Diğer EP | Zhao et al · Applied Physics Letters | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | – | – | – | – | – | Bu yayında özet bulunmuyor. |
| IRE | Hogenes et al · Sci Rep | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | The final ablation zone created with irreversible electroporation (IRE) depends on the size, shape and strength of the electric field that is influenced by several parameters. A profound und… |
| Gen ET | Forjanič et al · IEEE Trans Biomed Eng | 2019 | İn Siliko / Modelleme | Hesaplamalı Model | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | – | ELECTRO cell B10 HVLV | plazmid DNA · diğer yol | – | Objective: Skin is an attractive target tissue for gene transfer due to its size, accessibility, and its immune competence. One of the promising delivery methods is gene delivery by means of… |
| IRE | Gallinato et al · Phys Med Biol | 2019 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 1 / 1 | NanoKnife | – | – | The paper provides a numerical workflow, based on the 'real-life' clinical workflow of irreversible electroporation (IRE) performed for the treatment of deep-seated liver tumors. Thanks to a… |
| ECT | Berkenbrock et al · J Healthc Eng | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Electrochemotherapy is an anticancer treatment based on applying electric field pulses that reduce cell membrane selectivity, allowing chemotherapy drugs to enter the cells. In parallel to e… |
| Diğer EP | Lyu et al · Sci Rep | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | – | – | – | – | – | It was recently shown that electrolysis may play a substantial detrimental role in microfluidic electroporation. To overcome this problem, we have developed a non-electrolytic micro/nano ele… |
| Diğer EP | Sweeney et al · Technol Cancer Res Treat | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Electroporation is the process by which applied electric fields generate nanoscale defects in biological membranes to more efficiently deliver drugs and other small molecules into the cells.… |
| Gen ET | Forjanič et al · Biomed Eng Online | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | – | – | plazmid DNA · intratümöral | – | Background: The efficiency of gene electrotransfer, an electroporation-based method for delivery of pDNA into target tissues, depends on several processes. The method relies on application o… |
| Diğer EP | Mescia et al · IEEE Trans Biomed Eng | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Transmembran Potansiyel Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | During the past decades, the poration of cell membrane induced by pulsed electric fields has been widely investigated. Since the basic mechanisms of this process have not yet been fully clar… |
| IRE | Zhao et al · Biomed Eng Online | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, İrreversible Por Oluşumu ve Hücre Ölümü | – | BTX ECM830, AngioDynamics monopolar electrodes | – | – | Background: Irreversible electroporation (IRE) therapy relies on pulsed electric fields to non-thermally ablate cancerous tissue. Methods for evaluating IRE ablation in situ are critical to … |
| IRE | Zhao et al · IEEE Trans Biomed Eng | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Unlabelled: For irreversible-electroporation (IRE)-based therapies, the underlying electric field distribution in the target tissue is influenced by the electroporation-induced conductivity … |
| Diğer EP | Bernardis et al · Open Physics | 2017 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator | – | – | In clinical treatments of a class of tumors, e . g . skin tumors, the drug uptake of tumor tissue is helped by means of a pulsed electric field, which permeabilizes the cell membranes. This … |
| IRE | Yang et al · Volume 3: Biomedical and Biotechnology Engineering | 2017 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | – | – | – | – | The aim of this study was to analyze five factors that are responsible for the ablation volume and maximum temperature during the procedure of irreversible electroporation (IRE). The five fa… |
| Diğer EP | Langus et al · Sci Rep | 2016 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Darbe Parametrelerinin Optimizasyonu | – | BetaTech | bleomisin | tam yanıt 95% | In silico experiments (numerical simulations) are a valuable tool for non-invasive research of the influences of tissue properties, electrode placement and electric pulse delivery scenarios … |
| IRE | Murovec et al · Biophys J | 2016 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | Custom-built electroporation system | – | – | Many approaches for studying the transmembrane potential (TMP) induced during the treatment of biological cells with pulsed electric fields have been reported. From the simple analytical mod… |
| Diğer EP | Bhonsle et al · Biomed Eng Online | 2015 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | BTX ECM830 | – | – | Background: For electroporation-based therapies, accurate modeling of the electric field distribution within the target tissue is important for predicting the treatment volume. In response t… |
| Diğer EP | Corovic et al · PLoS One | 2015 | İn Siliko / Modelleme | Hesaplamalı Model | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator | – | diğer 0.0086 mm (3 hayvan) | Vascular endothelium selectively controls the transport of plasma contents across the blood vessel wall. The principal objective of our preliminary study was to quantify the electroporation-… |
| IRE | Bonakdar et al · IEEE Trans Biomed Eng | 2015 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Doku İletkenliği ve Empedans Değişimi | – | BTX ECM830, IRE bipolar probe (AngioDynamics), IRE bipolar probe | – | – | Significance: Irreversible electroporation (IRE) is gaining popularity as a focal ablation modality for the treatment of unresectable tumors. One clinical limitation of IRE is the absence of… |
| IRE | Dermol et al · J Membr Biol | 2015 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | – | BetaTech | – | – | Electroporation is a phenomenon used in the treatment of tumors by electrochemotherapy, non-thermal ablation with irreversible electroporation, and gene therapy. When treating patients, eith… |
| Diğer EP | Becker et al · Math Biosci | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | Cliniporator | – | – | In this study we consider the physics underlying electroporation which is administered to skin in order to radically increase transdermal drug delivery. The method involves the application o… |
| Diğer EP | Kasimova et al · Biophysical Journal | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | – | – | – | diğer | – | Bu yayında özet bulunmuyor. |
| Diğer EP | David et al · Annu Int Conf IEEE Eng Med Biol Soc | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electric fields delivered across biological cells can cause structural and functional changes to the cell membrane, such as electroporation. An important application of electroporation is in… |
| IRE | Dermol et al · Bioelectrochemistry | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | Cliniporator | – | – | High voltage electric pulses cause electroporation of the cell membrane. Consequently, flow of the molecules across the membrane increases. In our study we investigated possibility to predic… |
| IRE | Kurata et al · International Journal of Heat and Mass Transfer | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | – | – | – | – | Irreversible electroporation (IRE) is a novel method to ablate abnormal cells by applying a high voltage between the electrodes punctured in abnormal tissues. The cell membrane exposed to th… |
| IRE | Nickfarjam et al · Int J Hyperthermia | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Purpose: Irreversible electroporation (IRE) is a new tumour ablation method used in cancer treatment procedures. In a successful IRE treatment it is crucial to impose minimum thermal damage … |
| IRE | Phillips · J Biomech Eng | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | BTX Caliper Electrodes | – | – | Nonthermal irreversible electroporation (NTIRE) is an ablation modality that utilizes microsecond electric fields to produce nanoscale defects in the cell membrane. This results in selective… |
| ECT | Ritter et al · Biomed Tech (Berl) | 2013 | İn Siliko / Modelleme | Hesaplamalı Model | – | – | – | – | – | Article Fem-Driven Parameter Optimization of an Electrochemotherapy Catheter Prototype was published on September 7, 2013 in the journal Biomedical Engineering / Biomedizinische Technik (vol… |
| ECT | Campana et al · IEEE Trans. Magn. | 2013 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | A multiobjective optimization method is used to design a treatment planning based on electrochemotherapy (ECT). A penalty function technique is coupled to NSGA algorithm in order to identify… |
| Gen ET | Corovic et al · Biomed Eng Online | 2013 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Background: Electroporation based therapies and treatments (e.g. electrochemotherapy, gene electrotransfer for gene therapy and DNA vaccination, tissue ablation with irreversible electropora… |
| IRE | Long · Technol Cancer Res Treat | 2013 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – / 4 | – | – | – | Irreversible electroporation (IRE) has been shown to be an effective method of killing cells locally. In contrast to radiofrequency ablation, the mechanism by which cells are thought to die … |
| IRE | Mahnič-Kalamiza et al · BMC Med Educ | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin | – | Background: Electrochemotherapy is a local treatment that utilizes electric pulses in order to achieve local increase in cytotoxicity of some anticancer drugs. The success of this treatment … |
| IRE | Arena et al · Appl. Phys. Lett. | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Phase change materials (PCMs) capable of storing a large amount of heat upon transitioning from the solid-to-liquid state have been widely used in the electronics and construction industries… |
| Diğer EP | Garcia et al · Annu Int Conf IEEE Eng Med Biol Soc | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electroporation-based therapies have been gaining momentum as minimally invasive techniques to facilitate transport of exogenous agents, or directly kill tumors and other undesirable tissue … |
| Diğer EP | Golberg et al · Technol Cancer Res Treat | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Kas Kasılması ve Anestezi Gereksinimi, Elektrot Geometrisi ve Yerleşimi | – | BTX model ECM 830 | – | – | The electric field threshold for muscle contraction is two orders of magnitudes lower than that for electroporation. Current electroporation treatment planning and electrode design studies f… |
| ECT | Pavliha et al · Bioelectrochemistry | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | 10 | Cliniporator VITAE | bleomisin · intravenöz | – | Electrochemotherapy uses electroporation for enhancing chemotherapy. Electrochemotherapy can be performed using standard operating procedures with predefined electrode geometries, or using p… |
| Gen ET | Zupanic et al · Phys Med Biol | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator VITAE | – | – | In recent years, cancer electrochemotherapy (ECT), gene electrotransfer for gene therapy and DNA vaccination (GET) and tissue ablation with irreversible electroporation (IRE) have all entere… |
| Diğer EP | Čorović et al · J Membr Biol | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | PS 15 | diğer · intravenöz | – | In vivo electroporation is used as an effective technique for delivery of therapeutic agents such as chemotherapeutic drugs or DNA into target tissue cells for different biomedical purposes.… |
| IRE | Neal et al · IEEE Trans Biomed Eng | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | BTX ECM830 | – | – | Irreversible electroporation is a new technique to kill cells in targeted tissue, such as tumors, through a nonthermal mechanism using electric pulses to irrecoverably disrupt the cell membr… |
| Diğer EP | Daniels et al · PLoS One | 2011 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | This study explores the hypothesis that combining the minimally invasive surgical techniques of cryosurgery and pulsed electric fields will eliminate some of the major disadvantages of these… |
| Diğer EP | Mahmood et al · Bioelectrochemistry | 2011 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Current technology has limited applicability for electroporation based treatment of deep-seated tumors, and is in general, not optimized in terms of compliance with clinically relevant param… |
| Diğer EP | Jiang et al · Math Biosci | 2011 | İn Siliko / Modelleme | Hesaplamalı Model | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | plazmid DNA | – | Externally applied voltages can create transient, non-selective pores in a cell's membrane, a phenomenon known as electroporation. Electroporation has reduced toxicity, is easy to perform, a… |
| Diğer EP | Kranjc et al · IEEE Trans Med Imaging | 2011 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | PEF generator (custom-built) | – | tam yanıt 62% (15 hasta) | Electroporation is a phenomenon caused by externally applied electric field of an adequate strength and duration to cells that results in the increase of cell membrane permeability to variou… |
| Gen ET | Pavšelj et al · International Journal of Heat and Mass Transfer | 2011 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · diğer yol | – | The use of electric pulses to increase cell membrane permeability – electroporation – has, among other applications also been used on skin for (a) enhanced transdermal molecular delivery or … |
| IRE | Adeyanju et al · Technol Cancer Res Treat | 2011 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) is a novel therapy used to ablate tumors with high-field electric pulses applied in short durations. It is important to reduce the generation of heat in IR… |
| Diğer EP | Arena et al · IEEE Trans Biomed Eng | 2011 | İn Siliko / Modelleme | Hesaplamalı Model | Transmembran Potansiyel Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | This study introduces the use of high-frequency pulsed electric fields for tissue electroporation. Through the development of finite element models and the use of analytical techniques, elec… |
| IRE | Garcia et al · Biomed Eng Online | 2011 | İn Siliko / Modelleme | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | – / 1 | NanoKnife | – | ablasyon hacmi 0.058 cm³ (1 lezyon) | Background: Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedu… |
| Diğer EP | Čorović et al · Med Biol Eng Comput | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Darbe Parametrelerinin Optimizasyonu | – | PS 15, Cliniporator | – | – | The aim of this study was to theoretically and experimentally investigate electroporation of mouse tibialis cranialis and to determine the reversible electroporation threshold values needed … |
| Gen ET | Zupanic et al · Biomed Eng Online | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | – | – | plazmid DNA | nesnel yanıt 81 cm³ | Background: Electroporation-based gene therapy and DNA vaccination are promising medical applications that depend on transfer of pDNA into target tissues with use of electric pulses. Gene el… |
| ECT | Kos et al · J Membr Biol | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Treatment of cutaneous and subcutaneous tumors with electrochemotherapy has become a regular clinical method, while treatment of deep-seated tumors is still at an early stage of development.… |
| ECT | Miklavcic et al · Radiol Oncol | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Background: In order to reduce the side-effects of chemotherapy, combined chemotherapy-electroporation (electrochemotherapy) has been suggested. Electroporation, application of appropriate e… |
| IRE | Maor et al · J Biomech Eng | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Termal Etki ve Joule Isınması, Reversible Membran Permeabilizasyonu | – | – | – | – | Tissue ablation finds an increasing use in modern medicine. Nonthermal irreversible electroporation (NTIRE) is a biophysical phenomenon and an emerging novel tissue ablation modality, in whi… |
| ECT | Corovic et al · Biomed Eng Online | 2009 | İn Siliko / Modelleme | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Background: Electrochemotherapy is an effective approach in local tumour treatment employing locally applied high-voltage electric pulses in combination with chemotherapeutic drugs. In plann… |
| Gen ET | Lackovic et al · IEEE Trans. Dielect. Electr. Insul. | 2009 | İn Siliko / Modelleme | Hesaplamalı Model | Darbe Parametrelerinin Optimizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electrochemotherapy and electrogene therapy are new methods in molecular medicine based on electroporation-mediated introduction of foreign molecules (chemotherapeutic drugs, DNA) into targe… |
| Diğer EP | Pucihar et al · IEEE Trans Biomed Eng | 2009 | İn Siliko / Modelleme | Hesaplamalı Model | Transmembran Potansiyel Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | We describe a finite-element model of a realistic irregularly shaped biological cell in an external electric field that allows the calculation of time-dependent changes of the induced transm… |
| ECT | Granot et al · Int J Heat Mass Transf | 2008 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | – | bleomisin · intratümöral | – | Reversible electroporation is the temporary permeabilization of the cell membrane through the formation of nano-scale pores that are transient defects in the membrane. These pores are caused… |
| ECT | Županič et al · Radiology and Oncology | 2008 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrot Geometrisi ve Yerleşimi, Elektrik Alan Dağılımı ve Modellemesi | – / 4 | – | – | – | Optimization of electrode position and electric pulse amplitude in electrochemotherapyBackground. In addition to the chemotherapeutic drug being present within the tumor during electric puls… |
| ECT | Corovic et al · IEEE Trans. Plasma Sci. | 2008 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | – | – | bleomisin · intravenöz | – | Electrochemotherapy (ECT) is an effective antitumor treatment employing locally applied high-voltage electric pulses in combination with chemotherapeutic drugs. For successful ECT, the entir… |
| Diğer EP | Pavselj et al · IEEE Trans. Plasma Sci. | 2008 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | – | – | plazmid DNA | – | —The protective function of skin (its low permeability) presents a formidable obstacle in therapeutical applications such as transdermal drug delivery and gene delivery in skin. One of the p… |
| Gen ET | Pavšelj et al · Radiology and Oncology | 2008 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Numerical modeling in electroporation-based biomedical applicationsBackground. Numerous experiments have to be performed before a biomedical application is put to practical use in clinical e… |
| ECT | Sel et al · IEEE Trans Biomed Eng | 2007 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | – | Cliniporator | – | – | In electrochemotherapy (ECT) electropermeabilization, parameters (pulse amplitude, electrode setup) need to be customized in order to expose the whole tumor to electric field intensities abo… |
| Diğer EP | Pavselj ve Miklavcic · – | 2007 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | The application of electric pulses to biological cells causes the electroporation of cell membrane, increasing its permeability thus enabling the uptake of larger molecules that otherwise ca… |
| Diğer EP | Pavšelj et al · Ann Biomed Eng | 2007 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator | plazmid DNA · diğer yol | yaşam kalitesi 0 diğer | As an alternative to viral methods that are controversial because of their safety issues, chemical and physical methods have been developed to enhance gene expression in tissues. Reversible … |
| IRE | Edd et al · Technol Cancer Res Treat | 2007 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Irreversible Electroporation (IRE) is a new drug-free method to ablate undesirable tissue of particular use in cancer therapy. IRE achieves cell death within the targeted tissue through a se… |
| Diğer EP | Becker et al · J Biomech Eng | 2005 | İn Siliko / Modelleme | Hesaplamalı Model | Termal Etki ve Joule Isınması, Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Electroporation is an approach used to enhance the transport of large molecules to the cell cytosol in which a targeted tissue region is exposed to a series of electric pulses. The cell memb… |
| Diğer EP | Sel et al · IEEE Trans Biomed Eng | 2005 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Doku İletkenliği ve Empedans Değişimi | – | Jouan GHT 1287B | bleomisin | – | Permeabilization, when observed on a tissue level, is a dynamic process resulting from changes in membrane permeability when exposing biological cells to external electric field (E). In this… |
| Diğer EP | Nesmith et al · HardwareX | 2026 | Teknik / Cihaz Çalışması | – | Gen Elektrotransferi (Plazmid DNA) | – | OpenPore, Bio-Rad Gene Pulser | plazmid DNA · intratümöral | – | The OpenPore pulse generator is a battery powered, portable exponential decay pulse generator for performing mammalian cell electroporation. Electroporation is a common technique for transpo… |
| Diğer EP | Xu et al · J. Innov. Opt. Health Sci. | 2025 | Teknik / Cihaz Çalışması | – | Elektrot Geometrisi ve Yerleşimi | – | high voltage pulse generator, electrodes | – | – | Electroacoustic Tomography (EAT) is an imaging technique that detects ultrasound waves induced by electrical pulses, offering a solution for real-time electroporation monitoring. This study … |
| Diğer EP | Bougandoura et al · Bioelectricity | 2024 | Teknik / Cihaz Çalışması | – | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | – | – | – | – | Cancer remains a global health challenge, necessitating effective treatments with fewer side effects. Traditional methods such as chemotherapy and surgery often have complications. Pulsed el… |
| Diğer EP | Sheng et al · Bio-des. Manuf. | 2024 | Teknik / Cihaz Çalışması | – | Elektrot Geometrisi ve Yerleşimi | – | pulse signal generator | plazmid DNA | diğer 0 diğer (1 bildirilmemiş) | Intracellular electrophysiological research is vital for biological and medical research. Traditional planar microelectrode arrays (MEAs) have disadvantages in recording intracellular action… |
| Diğer EP | Sarnago et al · IEEE Trans. Power Electron. | 2023 | Teknik / Cihaz Çalışması | – | – | – | – | – | – | Electroporation is a promising cancer treatment based on applying short electric field pulses. In this context, highly versatile pulse generators are required to generate high-voltage low-ri… |
| IRE | Lorenzo et al · IEEE Trans Biomed Eng | 2021 | Teknik / Cihaz Çalışması | – | Doku İletkenliği ve Empedans Değişimi, Termal Etki ve Joule Isınması | – | AFG31000 function generator | – | – | Objective: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue; this results in changes in electrical properties detectable … |
| Diğer EP | Uluer et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2021 | Teknik / Cihaz Çalışması | – | – | – | – | – | – | An end-fire dielectric rod antenna is proposed as a heating device for integration with an array of electroporation electrodes in order to enable efficient delivery of DNA into the cells tha… |
| Diğer EP | López-Alonso et al · Energies | 2021 | Teknik / Cihaz Çalışması | – | Transmembran Potansiyel Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | Electroporation is a phenomenon that consists of increasing the permeability of the cell membrane by means of high-intensity electric field application. Nowadays, its clinical application to… |
| ECT | Pirc et al · Electronics | 2021 | Teknik / Cihaz Çalışması | – | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | – | BetaTech, prototype device | bleomisin · intratümöral | tam yanıt 86% (7 hayvan) | Currently, in high-frequency electroporation, much progress has been made but limited to research groups with custom-made laboratory prototype electroporators. According to the review of ele… |
| IRE | Sano et al · Bioelectricity | 2020 | Teknik / Cihaz Çalışması | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | custom-built pulse generation system | – | ablasyon hacmi 0.73 cm³ | Background: Irreversible electroporation (IRE) induces cell death through nonthermal mechanisms, however, in extreme cases, the treatments can induce deleterious thermal transients. This stu… |
| ECT | Di Barba et al · JAE | 2019 | Teknik / Cihaz Çalışması | – | Elektrik Alan Dağılımı ve Modellemesi | – | – | – | – | In the paper, a multi-objective optimization of an electrode pair for electrochemotherapy is performed. The aim is to design the electrode pair geometry in order to obtain an effective treat… |
| Diğer EP | Elgenedy et al · IEEE Trans. Power Electron. | 2019 | Teknik / Cihaz Çalışması | – | – | – | – | – | – | In order to overcome the limitations of the existing classical and solid-state Marx pulse generators, this paper proposes a new modular multilevel voltage-boosting Marx pulse generator (BMPG… |
| IRE | Ritter et al · Technol Cancer Res Treat | 2018 | Teknik / Cihaz Çalışması | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | BTX ECM830 | – | – | Irreversible electroporation and electrochemotherapy are 2 innovative electroporation-based minimally invasive therapies for the treatment of cancer. Combining nonthermal effects of irrevers… |
| IRE | van den Bos et al · J Vasc Interv Radiol | 2016 | Teknik / Cihaz Çalışması | – | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | – | NanoKnife | – | – | Purpose: Irreversible electroporation (IRE) uses high-voltage electric fields to achieve cell death. Although the mechanism of IRE is mainly designated as nonthermal, development of secondar… |
| Diğer EP | Kranjc et al · J. Phys.: Conf. Ser. | 2013 | Teknik / Cihaz Çalışması | – | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | – | Cliniporator VITAE | – | – | Electroporation is a phenomenon caused by externally applied electric field to cells that results in an increase of cell membrane permeability to various molecules. Accurate coverage of the … |
| Diğer EP | Guido et al · Microelectronic Engineering | 2012 | Teknik / Cihaz Çalışması | – | Darbe Parametrelerinin Optimizasyonu | – | – | – · diğer yol | – | Electroporation is a widely used method for increasing the permeability of the cellular membrane. Impermeant exogenous substances (e.g., DNA, proteins, peptides, dyes) can thus be introduced… |
| Diğer EP | Troszak et al · Biomed Microdevices | 2010 | Teknik / Cihaz Çalışması | – | – | – | – | – | – | Traditional macro and micro-electroporation devices utilize facing electrodes, which generate electric fields inversely proportional to their separation distance. Although the separation dis… |
| Diğer EP | Wilke et al · Sensors and Actuators A: Physical | 2005 | Teknik / Cihaz Çalışması | – | Elektrot Geometrisi ve Yerleşimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin | – | This paper describes a system of silicon microneedle electrode arrays for electroporation with integrated temperature and fluidic system for drug delivery. In this research we have developed… |
| Diğer EP | Behrend et al · IEEE Trans. Dielect. Electr. Insul. | 2003 | Teknik / Cihaz Çalışması | – | Apoptoz İndüksiyonu, Nanosaniye Darbeli Elektrik Alan (nsPEF) | – | – | – | – | This paper describes three pulse generators: a spark gap switched coaxial cable, a spark gap switched Blumlein, and a solid state modulator, developed for applying ultrashort electrical puls… |
| ECT | Tomov et al · Bioelectrochemistry | 2000 | Teknik / Cihaz Çalışması | – | Bleomisin Hücre İçi Birikiminin Artması, Gen Elektrotransferi (Plazmid DNA) | – | – | bleomisin | – | The electrodes used for electroporation, electrofusion, and electrotransfection, as well as in electrochemotherapy should not interact with the object and release electrolysis products. We s… |
| ECT | Brandisky et al · Bioelectrochem Bioenerg | 1999 | Teknik / Cihaz Çalışması | – | Elektrot Geometrisi ve Yerleşimi | – | – | – | – | Electrochemotherapy is a method for cancer treatment consisting in combining intratumor injection of cytotoxic agent with the application of intensive electrical stimuli. Thus transient cell… |
| Diğer EP | Yang et al · Bioelectrochemistry | 2026 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu | – | – | – | – | The rigid cell wall of microalgae limits efficient intracellular protein extraction. Here, three pulsed electric field (PEF) energy distribution strategies-high-voltage few-pulse (HP), low-v… |
| Diğer EP | Barozzi et al · IEEE Access | 2026 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Doku İletkenliği ve Empedans Değişimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | BTX ECM830 | – | – | Electroporation of biological tissues induced by high-intensity, short-duration voltage pulses modify tissue permeability to molecules and ions allowing applications like drug delivery and g… |
| IRE | Guo et al · Bioelectrochemistry | 2026 | Deneysel Biyofizik Çalışması | Deneysel Sistem | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | – | – | – | transfeksiyon verimi 0 diğer (1 bildirilmemiş) | The traditional Hodgkin-Huxley (HH) model is mainly applicable to neuronal excitability under low electric fields but ails at high field intensities. In this study, an improved HH model inco… |
| Diğer EP | Baker et al · Sci Rep | 2024 | Deneysel Biyofizik Çalışması | İnsan | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Transmembran Potansiyel Değişimi | – | – | – | – | Most simulations of electric field driven bioeffects have considered spherical cellular geometries or probed symmetrical structures for simplicity. This work assesses cellular transmembrane … |
| Gen ET | Kauth et al · Ann Biomed Eng | 2023 | Deneysel Biyofizik Çalışması | İnsan | Reversible Membran Permeabilizasyonu, Elektrot Geometrisi ve Yerleşimi | – | – | plazmid DNA · diğer yol | – | When a cell or tissue is exposed to a pulsed electric field (100-1000 V/cm), the cellular membrane permeabilizes for biomolecules that cannot pass an intact cellular membrane. During this el… |
| Diğer EP | Briz et al · Bioelectrochemistry | 2023 | Deneysel Biyofizik Çalışması | İnsan | Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Electroporation is a phenomenon produced in the cell membrane when it is exposed to high pulsed electric fields that increases its permeability. Among other application fields, this phenomen… |
| IRE | Peng et al · Adv Healthc Mater | 2023 | Deneysel Biyofizik Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | custom-built pulse generator | – | – | In this work, we proposed nµPEF, a novel pulse configuration combining nanosecond and microsecond pulses (nµPEF), to enhance tumor ablation in irreversible electroporation (IRE) for oncologi… |
| IRE | Cvetkoska et al · Sci Rep | 2022 | Deneysel Biyofizik Çalışması | İnsan | Kas Kasılması ve Anestezi Gereksinimi, İrreversible Por Oluşumu ve Hücre Ölümü | 25 | – | – | – | To minimize neuromuscular electrical stimulation during electroporation-based treatments, the replacement of long monophasic pulses with bursts of biphasic high-frequency pulses in the range… |
| ECT | Tamra et al · IEEE Trans Biomed Eng | 2022 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | BetaTech | bleomisin | hücre canlılığı 53% (50 hasta) | This paper presents a 40 GHz microwave biosensor used to monitor and characterize single cells (THP-1) subjected to electrochemotherapy and obtain an electronic signature of the treatment ef… |
| Diğer EP | Ganesan et al · Electronics | 2022 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Electroporation is a next generation bioelectronics device. The emerging application of electroporation requires high voltage pulses having a pulse-width in the nanosecond range. The essenti… |
| Diğer EP | Lv et al · IEEE Access | 2020 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | custom-built electroporation generator | – | – | When delivered across a cell, certain pulsed electric fields can cause an increase in the cell membrane permeability through a biophysical process known as electroporation. The current signa… |
| Diğer EP | Ye et al · Micromachines (Basel) | 2020 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Doku İletkenliği ve Empedans Değişimi | – | – | diğer · diğer yol | – | The electroporation system can serve as a tool for the intracellular delivery of foreign cargos. However, this technique is presently limited by the inaccurate electric field applied to the … |
| IRE | López-Alonso · Sensors (Basel) | 2020 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | custom high-voltage generator | – | – | Classical application of electroporation is carried out by using fixed protocols that do not clearly assure the complete ablation of the desired tissue. Nowadays, new methods that pursue the… |
| Diğer EP | Chiapperino et al · Bioelectromagnetics | 2019 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Transmembran Potansiyel Değişimi | – | – | – | – | In this work, the electroporation phenomenon induced by pulsed electric field on different nucleated biological cells is studied. A nonlinear, non-local, dispersive, and space-time multiphys… |
| Diğer EP | Hristov et al · Biochim Biophys Acta Biomembr | 2018 | Deneysel Biyofizik Çalışması | İnsan | Nanosaniye Darbeli Elektrik Alan (nsPEF), Reversible Membran Permeabilizasyonu | – | custom-built MOSFET-based generator | – | – | We compared membrane permeabilization by nanosecond pulsed electric field (nsPEF) in HEK293 cells with and without assembled CaV1.3 L-type voltage-gated calcium channel (VGCC). Individual ce… |
| Diğer EP | Zhao et al · Sensors (Basel) | 2018 | Deneysel Biyofizik Çalışması | İnsan | Doku İletkenliği ve Empedans Değişimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | – | – | Skin penetration is related to efficiencies of drug delivery or ISF extraction. Normally, the macro-electrode is employed in skin permeability promotion and evaluation, which has the disadva… |
| Diğer EP | Davies et al · Biomed. Phys. Eng. Express | 2018 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Doku İletkenliği ve Empedans Değişimi | – | – | – | – | Electroporation is the creation of pores in a cell by applying an external electrical field and creating a voltage in the range of 200 mV–1 V across the cell’s membrane. This process is used… |
| ECT | Calin et al · Biomed Opt Express | 2017 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu | – | ELECTRO cell B10 | – | – | Changes in optical and shape-related characteristics of B16F10 cells after electroporation were investigated using digital holographic microscopy (DHM). Bipolar rectangular pulses specific f… |
| IRE | Yao · PLoS One | 2017 | Deneysel Biyofizik Çalışması | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) produced by a pulsed electric field can ablate tissue. In this study, we achieved an enhancement in ablation area by using a combination of short high-volt… |
| IRE | Miklovic et al · Ann Biomed Eng | 2017 | Deneysel Biyofizik Çalışması | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830, custom pulse generator | – | ablasyon hacmi 8.46 cm³ | Several focal therapies are being investigated clinically to treat tumors in which surgery is contraindicated. Many of these ablation techniques, such as radiofrequency ablation and microwav… |
| Diğer EP | Breton et al · IEEE Trans. Magn. | 2015 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu, Nekroz ve Nekroptoz | – | – | – | – | We propose a non-linear steady-state model of irreversible electropermeabilization in a biological tissue. The non-linear problem is solved using a modified fixed point iteration. The unknow… |
| IRE | KURATA et al · JBSE | 2013 | Deneysel Biyofizik Çalışması | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | BTX ECM830 | – | – | Irreversible electroporation (IRE) is attracting much attention as a less-invasive therapy to ablate abnormal tissues. With a pair of electrodes inserted into the tissue, the IRE perforates … |
| ECT | Dotsinsky et al · Biotechnology & Biotechnological Equipment | 2012 | Deneysel Biyofizik Çalışması | İnsan | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | 37 / 47 | Chemipulse III, Chemipulse | bleomisin · intratümöral | – | Electrochemotherapy is based on electroporation, which creates aqueous pathways in the cell membrane as a result of applied short intensive electric field usually generated by high voltage e… |
| ECT | Raeisi · – | 2012 | Deneysel Biyofizik Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | – | Cliniporator, Jouan GHT 1287 | bleomisin | – | Biomedical imaging techniques play an important role in all phase of cancer management including detection, screening, biopsy guidance, staging, prognosis, therapy planning, therapy guidance… |
| Diğer EP | Golzio et al · Phys Chem Chem Phys | 2010 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu, Elektrot Geometrisi ve Yerleşimi | – | – | – | – | An experimental validation of electropermeabilization inducing field distribution in tissue predicted by simulation for needle electrodes is described giving a direct visualization of the pe… |
| Diğer EP | Kotnik et al · J Membr Biol | 2010 | Deneysel Biyofizik Çalışması | Hücre Kültürü | Transmembran Potansiyel Değişimi, Reversible Membran Permeabilizasyonu | – | – | – | – | Exposure of a cell to an electric field results in inducement of a voltage across its membrane (induced transmembrane voltage, DeltaPsi (m)) and, for sufficiently strong fields, in a transie… |
| Diğer EP | Mottet et al · J. Micromech. Microeng. | 2010 | Deneysel Biyofizik Çalışması | Deneysel Sistem | – | – | – | – | – | International audience |
| IRE | Hjouj et al · J Membr Biol | 2010 | Deneysel Biyofizik Çalışması | – | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | BTX 830 | – | – | We introduce and characterize the use of MRI for studying nonthermal irreversible electroporation (NTIRE) in a vegetative tissue model. NTIRE is a new minimally invasive surgical technique f… |
| Diğer EP | Vernier et al · PLoS One | 2009 | Deneysel Biyofizik Çalışması | İnsan | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | USC pulse generator, Cliniporator, FID Technology pulse generator | – | – | Reversible electropermeabilization (electroporation) is widely used to facilitate the introduction of genetic material and pharmaceutical agents into living cells. Although considerable know… |
| IRE | Davalos et al · International Journal of Heat and Mass Transfer | 2008 | Deneysel Biyofizik Çalışması | Deneysel Sistem | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Certain electrical fields, when applied across a cell membrane, can have the sole effect of membrane permeabilization, which is referred to as electroporation. When the permeabilization is ir… |
| IRE | Esser et al · Technol Cancer Res Treat | 2007 | Deneysel Biyofizik Çalışması | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Local and drug-free tissue treatment by irreversible electroporation (IRE) involves the creation of aqueous pores in a cell's plasma membrane (PM) and leads to non-thermal cell death by necr… |
| Diğer EP | Pliquett et al · Bioelectrochemistry | 2004 | Deneysel Biyofizik Çalışması | İnsan | Termal Etki ve Joule Isınması | – | – | – | – | The electroporative effect on the stratum corneum (SC) is highly localized. However, the fractional area for the transport of small ions and larger ionic species differs considerably during … |
| ECT | Cemazar et al · Br J Cancer | 2001 | Deneysel Biyofizik Çalışması | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | – | Jouan GHT 1287 | bleomisin | – | Recent studies have indicated that the antitumour effectiveness of electrochemotherapy, a combination of chemotherapeutic drugs with application of high voltage electric pulses applied to th… |
| Diğer EP | Pliquett et al · Bioelectrochemistry and Bioenergetics | 1996 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Termal Etki ve Joule Isınması, Transmembran Potansiyel Değişimi | – | Electro Cell Manipulator 600 | – | – | Eiectroporation is well known to depend non-linearly on the magnitude and duration of the change AU(t) in transmembrane voltage. In the case of cell suspension experiments, an electric field… |
| Diğer EP | Rols et al · Journal of Electroanalytical Chemistry and Interfacial Electrochemistry | 1990 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu | – | CNRS call electropulser | – | – | Cells can be permeabilized transiently when pulsed b y high intensity short duration electric fields. T h e molecular m e c h a n i s m s underlaying this electropermeabilization are still u… |
| Gen ET | Ishii-Teshima et al · – | 2026 | Ön Baskı | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | – | A microelectrode-based electroporator serves as a customizable microscale electroporation platform. For practical applications, stable operation of the system and precise estimation of the e… |
| ECT | Peña et al · – | 2025 | Ön Baskı | Hayvan (İn Vivo) | – | – / 2 | ELECTROVET EZ, ELECTROVET EZ electroporator | bleomisin · intravenöz | tam yanıt 2 gün (2 hayvan) | Bu yayında özet bulunmuyor. |
| Diğer EP | Iimura et al · – | 2025 | Ön Baskı | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu | – | – | diğer | hücre canlılığı 100% | Electroporation has traditionally been widely performed using metal electrodes, but reports indicate these electrodes exhibit cytotoxicity. Polypyrrole, a conductive and biocompatible polyme… |
| Diğer EP | Yoshida et al · – | 2024 | Ön Baskı | – | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA · diğer yol | – | Non-viral mediated plasmid DNA transfection by electroporation (EP) is an established method for gene transfection. In this study, the usefulness of direct EP at an intradermal (i.d.) site (… |
| Diğer EP | Lopez-Alonso et al · – | 2024 | Ön Baskı | Hücre Kültürü | – | – | custom DAC-based multilevel prototype | – | hücre canlılığı 100% (10000 bildirilmemiş) | Bu yayında özet bulunmuyor. |
| Diğer EP | García Sánchez · – | 2023 | Tez | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | – | – | diğer · diğer yol | – | The present PhD dissertation is focused on the design and implementation of a microelectrode system capable of performing electroporation and electrical impedance measurements to adherent ce… |
| ECT | Blažič et al · Proceedings of the 4th URSI Atlantic RadioScience Conference – AT-RASC 2024 | 2024 | Kongre Özeti | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | L-POR V0.1 | – | – | Electroporation is a phenomenon in which exposure of a cell to pulsed electric field causes the formation of pores in the cell membrane.During the period of increased membrane permeability, … |
| Diğer EP | Dou et al · 2024 MicroTAS Book of Abstracts | 2024 | Kongre Özeti | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi | – | – | plazmid DNA · diğer yol | transfeksiyon verimi 68.8% | Reference No: 0625 AN INTERGATED PLATFORM ENABLING ISOLATING AND ELECTROPORATION TRANSFECTING OF CIRCULATING TUMOR CELLS HIGH EFFICIENTLY Songtao Dou1, Qingmei Xu2, Shitao Shen2, Qi Wang3, Y… |
| Gen ET | Ursic Valentinuzzi et al · Poster Presentations | 2022 | Kongre Özeti | – | İnterlökin-12 Aracılı İmmün Uyarım, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | bleomisin · intratümöral | tam yanıt 38% | Background Electrochemotherapy (ECT) exhibits high therapeutic effectiveness in the clinic, achieving up to 80% local tumor control but without a systemic (abscopal) effect. It was proposed … |
| Diğer EP | Folprecht et al · Proceedings II of the 28st Conference STUDENT EEICT 2022: Selected papers. | 2022 | Kongre Özeti | – | Kas Kasılması ve Anestezi Gereksinimi | – | – | – | – | This paper discusses an application of different waveforms during a cell electroporation process. Latest scientific papers emphasize advantages of asymmetrical waveform applied to tissue. Hi… |
| ECT | Malysko et al · 2021 13th International Conference on Measurement | 2021 | Kongre Özeti | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | – | – | diğer · intravenöz | – | Electroporation is a highly effective method in various fields of application, including cancer treatment, where when combined with drugs (called electrochemotherapy), it improves treatment … |
| Diğer EP | Brimmo et al · World Congress on Electrical Engineering and Computer Systems and Science | 2021 | Kongre Özeti | – | Elektrot Geometrisi ve Yerleşimi | – | – | plazmid DNA | – | Here, a simple pin-plate electrode setup has been constructed to reliably electroporate biological cells within droplets. The process constitutes temporary permeabilization of the plasma mem… |
| ECT | Aleynik et al · 2014 12th International Conference on Actual Problems of Electronics Instrument Engineering (APEIE) | 2014 | Kongre Özeti | – | – | – / 1 | – | sisplatin | – | A layout of the device for the treatment of malignant tumors with electroporation is developed. Investigation of the device characteristics is conducted. Animal model studies have confirmed … |
| ECT | Miklavčič · WIT Transactions on Biomedicine and Health | 2003 | Kongre Özeti | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | – | – | diğer | – | Electrochemotherapy is a technique where electric pulses in combination with chemotherapeutic agents are applied to tumor cells. In general, patients find electrochemotherapy tolerable, in s… |
| ECT | Music · WIT Transactions on Biomedicine and Health | 2003 | Kongre Özeti | Hücre Kültürü | – | – | – | – | – | Electrochemotherapy is a local treatment of tumors in which high voltage electric pulses are used for permeabilization of cell membrane (electroporation) thus enabling increased entry of che… |
| Diğer EP | Huang et al · 2002 Solid-State, Actuators, and Microsystems Workshop Technical Digest | 2002 | Kongre Özeti | – | Gen Elektrotransferi (Plazmid DNA) | – | – | plazmid DNA | – | We describe a chip that is capable of performing gene transfer in individual biological cells through single cell microelectroporation. Microfluidic channels are used to handle individual ce… |
| IRE | Rouientan et al · J Vasc Interv Radiol | 2026 | Editöryal / Mektup | – | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Kulbacka et al · Expert Opin Drug Deliv | 2025 | Editöryal / Mektup | – | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | – | – | diğer | – | 1. Drug resistance or even multidrug resistance (MDR) in cancer is still one of the greatest challenges in oncological therapy today. Many cancers develop mechanisms to evade conventional tr… |
| IRE | Tewari et al · Cardiovasc Intervent Radiol | 2025 | Editöryal / Mektup | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Bu yayında özet bulunmuyor. |
| ECT | Rembiałkowska et al · Pharmaceuticals (Basel) | 2024 | Editöryal / Mektup | – | – | 52 | – | – | – | This Special Issue is dedicated to the memory of Professor Jolanta Saczko (1964-2023), a remarkable leader whose guidance and dedication were instrumental in advancing electroporation-based … |
| Diğer EP | De Robertis et al · Vaccines (Basel) | 2023 | Editöryal / Mektup | – | – | – | – | – | – | Immunotherapy can now be regarded as an attractive approach for cancer and infectious disease treatments [...]. |
| Diğer EP | Heller et al · Technol Cancer Res Treat | 2019 | Editöryal / Mektup | İnsan | Darbe Parametrelerinin Optimizasyonu | – | – | – | – | Electroporation Based Therapies - Editorial Special Collection on ElectroporationBased Therapies: A Selection of Papers From the Second World Congress on Electroporation Technology in Cancer… |
| IRE | Miklavcic et al · Biomed Eng Online | 2015 | Editöryal / Mektup | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | – | bleomisin | – | When a cell is exposed to a sufficiently intense electric field (for a sufficient duration), local defects in the cell membrane appear and become permeable to molecules that otherwise cannot… |
| IRE | Heger et al · Hepatobiliary Pancreat Dis Int | 2015 | Editöryal / Mektup | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | – | – | – | – | Irreversible electroporation (IRE) is a CE- and FDAapproved treatment modality for pancreatic and liver tumors that is based on the site-confined destruction of tumor tissue by multiple shor… |
| IRE | Davalos et al · Prostate | 2015 | Editöryal / Mektup | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | – | – | – | – | Irreversible electroporation (IRE) describes a cellular response to electric field exposure, resulting in the formation of nanoscale defects that can lead to cell death. While this behavior … |
| Diğer EP | Miklavčič et al · J Membrane Biol | 2013 | Editöryal / Mektup | belirsiz | – | – | – | – | – | TO SPECIAL ISSUE Introduction to Third Special Electroporation-Based Technologies and Treatments Issue Damijan Miklavčič • Lluis M. Mir • P. Thomas Vernier Published online: 20 September 2… |
| Diğer EP | Heller · Technol Cancer Res Treat | 2002 | Editöryal / Mektup | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Gen Elektrotransferi (Plazmid DNA) | – | – | bleomisin | – | This special issue of Technology in Cancer Research and Treatment focuses on the versatility of electroporation. Contributed papers report on the basic mechanisms as well as the use of this … |
| Diğer EP | Hui · Biophys J | 1998 | Editöryal / Mektup | İnsan | – | – | – | – | – | Bu yayında özet bulunmuyor. |
| ECT | Vizintin et al · Radiol Oncol | 2023 | Düzeltme / Erratum | – | Sisplatin Hücre İçi Birikiminin Artması | – | – | sisplatin | – | In Figure 3A, three horizontal bars representing the standard deviation were incorrectly drawn.The corrected figure is shown below. |
| Kalsiyum EP | Hansen et al · PLoS One | 2015 | Düzeltme / Erratum | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Elektrik Alan Dağılımı ve Modellemesi | – | – | kalsiyum klorür | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Tao et al · Research (Wash D C) | 2026 | Belirtilmemiş | – | – | – | self-built device | diğer · diğer yol | – | Nonviral intracellular delivery based on pulsed-electric-field-induced electroporation is one of the most effective and widely used platforms in basic biological and biomedical research. How… |
| IRE | Xiang · BMC Surg | 2025 | Belirtilmemiş | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | 98 | – | – | – | Background: Irreversible electroporation (IRE) is a non-thermal ablation technique using high-voltage, low-energy pulses to induce cell membrane perforation and cell death. As an emerging th… |
| Diğer EP | Jiang et al · Precis Radiat Oncol | 2024 | Belirtilmemiş | – | Nanosaniye Darbeli Elektrik Alan (nsPEF) | – | VilniusTECH nanosecond electrical pulse generator | – | – | Background: Nanosecond pulsed electric fields (nsPEF)-based electroporation is a new therapy modality potentially synergized with radiation therapy to improve treatment outcomes. To verify i… |
| Diğer EP | Gurunian et al · Bioelectrochemistry | 2023 | Belirtilmemiş | – | – | – | Nanopore Reader, BLMchip Flowcell | – | – | We used voltage-clamp electroporation to obtain single-channel recordings of lipid pores and analyzed the idealized dwell-time sequences using Maximum-Likelihood Fitting. We observed traces … |
| Belirlenmedi | Plesnik et al · Anal Bioanal Chem | 2023 | Belirtilmemiş | – | Bleomisin Hücre İçi Birikiminin Artması | – | – | – | – | The effectiveness of highly polar agents in cancer treatment is well recognized, but their physicochemical properties make their analytical determination a demanding task. Their analysis req… |
| Diğer EP | Gurunian et al · Bioelectrochemistry | 2022 | Belirtilmemiş | – | – | – | – | – | – | Current-Clamp electroporation refers to the application of a constant current across a membrane which results in voltage fluctuations due to the creation of electropores. This method allows … |
| Belirlenmedi | Cindrič et al · ZdravVestn | 2021 | Belirtilmemiş | – | – | – | – | bleomisin | – | Koncept ireverzibilne elektroporacije kot samostojne ablacijske metode je bil prvič predstavljen pred petnajstimi leti. Ireverzibilna elektroporacija predstavlja alternativo uveljavljenim te… |
| Diğer EP | Zhou et al · Biomed Eng Online | 2019 | Belirtilmemiş | – | Reversible Membran Permeabilizasyonu | – | GROMACS | – | ağrı yanıtı 0% | Background: After the discovery of membrane-reversible electroporation decades ago, the procedure has been used extensively in biology, biotechnology and medicine. The research on the basic … |
| Diğer EP | Rauso · CDOAJ | 2018 | Belirtilmemiş | – | – | 40 | – | diğer · topikal | nesnel yanıt 30 adet (30 hasta) | Background: Assessment of the effectiveness and tolerability, with regard to facial photoageing, of a solution containing a blend of amino acids and low molecular weight hyaluronic acid (Sun… |
| Diğer EP | de Menorval et al · Sci Rep | 2016 | Belirtilmemiş | Hücre Kültürü | – | – | FID FPG 10-ISM10 | – | – | Human adipose mesenchymal stem cells (haMSCs) are multipotent adult stem cells of great interest in regenerative medicine or oncology. They present spontaneous calcium oscillations related t… |
| Diğer EP | Čorović et al · Biomed Eng Online | 2016 | Belirtilmemiş | – | – | 47 | – | – | – | Background: Electroporation-based applications require multidisciplinary expertise and collaboration of experts with different professional backgrounds in engineering and science. Beginning … |
| Diğer EP | Guenther et al · Biochem Biophys Res Commun | 2015 | Belirtilmemiş | İnsan | – | – | NanoKnife | bleomisin | – | Electroporation, the permeabilization of the cell membrane by brief, high electric fields, has become an important technology in medicine for diverse application ranging from gene transfecti… |
| Diğer EP | de Baere et al · Diagn Interv Imaging | 2014 | Belirtilmemiş | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü | – | – | – | – | Since the introduction of radiofrequency ablation (RFA) for the treatment of liver tumors at the end of the 1990s, indications for local ablation techniques have been extended to other organ… |
| Diğer EP | Mahnič-Kalamiza et al · Biochim Biophys Acta | 2014 | Belirtilmemiş | – | – | – | – | bleomisin · intravenöz | – | In many electroporation applications mass transport in biological tissue is of primary concern. This paper presents a theoretical advancement in the field and gives some examples of model us… |
| Diğer EP | Miklavčič · J Membr Biol | 2012 | Belirtilmemiş | İnsan | – | – | – | – | – | Exposure of biological cells to a sufficiently strong external electric field results in increased permeability of cell membranes, referred to as "electroporation." Since all types of cells … |
| Diğer EP | Anon · Molecular Therapy | 2012 | Belirtilmemiş | – | Gen Elektrotransferi (Plazmid DNA) | – | – | – | – | Bu yayında özet bulunmuyor. |
| Diğer EP | Mpendo et al · Retrovirology | 2012 | Belirtilmemiş | – | Gen Elektrotransferi (Plazmid DNA) | 37 | ICHOR TriGrid Delivery system | plazmid DNA | – | DNA vaccines are weakly immunogenic in humans and one way of increasing their immunogenicity is by administering the vaccines using electroporation (EP). This technique increases the uptake … |
| Diğer EP | Fernand et al · Biotechnol Bioeng | 2012 | Belirtilmemiş | – | – | – | BTX ECM830 | – | – | The mathematical solution to the electric field equation in cylindrical coordinates, has suggested to us a new experimental methodology and device for reducing experimental effort in designi… |
| Diğer EP | Lin et al · Biophysical Journal | 2011 | Belirtilmemiş | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | – | – | kalsiyum klorür | – | Bu yayında özet bulunmuyor. |
| ECT | Shankayi et al · J Membrane Biol | 2011 | Belirtilmemiş | – | – | – | – | – | – | J Membrane Biol (2011) 244:129 DOI 10.1007/s00232-011-9410-6 ERRATUM Erratum to: Tumor Growth Inhibited by Low-Voltage Amplitude and 5-kHz Frequency Electrochemotherapy Z. Shankayi • S. M. P… |
| Diğer EP | Kotulska et al · J Membr Biol | 2010 | Belirtilmemiş | – | – | – | – | – | – | Single metastable nanopores, appearing before the actual electroporation under constant-current conditions, are used to characterize the onset of electroporation. Unlike the long-lived elect… |
| IRE | Golberg et al · Technol Cancer Res Treat | 2010 | Belirtilmemiş | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | – | BTX ECM830 | – | – | Electroporation is a physical phenomenon in which pulsed electric fields applied across a cell produce transient (reversible) or permanent (irreversible) permeabilization of the cell membran… |
| ECT | Sersa et al · Curr Oncol | 2009 | Belirtilmemiş | – | – | – | – | bleomisin · intravenöz | nesnel yanıt 85% | Several novel tumour-targeting and drug-delivery approaches in cancer treatment are currently undergoing intensive investigation, among them physical approaches such as tissue electroporatio… |
| Diğer EP | Mossop et al · Ann Biomed Eng | 2007 | Belirtilmemiş | – | – | – | – | – | – | One of the key issues in electric field-mediated molecular delivery into cells is how the intracellular field is altered by electroporation. Therefore, we simulated the electric field in bot… |
| ECT | Dev ve Hofmann · Rehabilitation Oncology | 1995 | Belirtilmemiş | – | – | – | – | – | – | Bu yayında özet bulunmuyor. |
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