Genel Prensipler ve Biyofizik
Temel Bilimler
Elektroporasyonun biyofiziği, darbe parametrelerinin hücre ve doku düzeyindeki etkileri, ilaç taşınım mekanizmaları ve tedavi planlaması bu alanda toplanır. Korpusun en geniş bölümüdür ve diğer tüm uygulama alanlarının dayandığı temel bilgiyi içerir.
774toplam yayın
91klinik çalışma
477preklinik çalışma
158derleme
1991–2026yayın aralığı
Rejime Göre Kanıt Durumu
Reversible elektroporasyon (RE-ECT)
556yayın
62klinik
354preklinik
Klinik Kanıt
1991–2026 · Rutin Klinik Kullanımda
İrreversible elektroporasyon (IRE-ECT)
218yayın
29klinik
123preklinik
Klinik Kanıt
2003–2026 · Rutin Klinik Kullanımda
Bu Alanda Raporlanan Mekanizmalar
Terimler, yayın özetleri üzerinde otomatik eşleştirmeyle saptanmıştır; rakam terimin geçtiği yayın sayısını gösterir.
Reversible Membran Permeabilizasyonu 371
İrreversible Por Oluşumu ve Hücre Ölümü 262
Elektrik Alan Dağılımı ve Modellemesi 137
Gen Elektrotransferi (Plazmid DNA) 133
Darbe Parametrelerinin Optimizasyonu 127
Bleomisin Hücre İçi Birikiminin Artması 120
Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu 93
Elektrot Geometrisi ve Yerleşimi 75
Doku İletkenliği ve Empedans Değişimi 73
Apoptoz İndüksiyonu 55
Sisplatin Hücre İçi Birikiminin Artması 53
Termal Etki ve Joule Isınması 52
Çalışma Tipi Dağılımı
Çubuk uzunluğu en kalabalık çalışma tipine göre ölçeklenmiştir; yüzde ise alanın tamamındaki payı verir. Renk, çalışma tipinin kanıt basamağını gösterir; kanıt haritasındaki ile aynı ölçek.
| Çalışma tipi | Yayın | Bu alandaki payı |
|---|---|---|
| Randomize Klinik Çalışma | 6 | <%1 |
| Prospektif Klinik Çalışma | 9 | %1 |
| Klinik Çalışma | 71 | %9 |
| Retrospektif Klinik Çalışma | 3 | <%1 |
| Vaka Serisi | 2 | <%1 |
| Vaka Raporu | 8 | %1 |
| Sistematik Derleme / Meta-Analiz | 18 | %2 |
| Derleme | 140 | %18 |
| Hayvan Çalışması | 314 | %41 |
| İn Vitro Çalışma | 103 | %13 |
| İn Siliko / Modelleme | 52 | %7 |
| Teknik / Cihaz Çalışması | 6 | <%1 |
| Deneysel Biyofizik Çalışması | 8 | %1 |
| Ön Baskı | 6 | <%1 |
| Kongre Özeti | 3 | <%1 |
| Editöryal / Mektup | 9 | %1 |
| Düzeltme / Erratum | 4 | <%1 |
| Belirtilmemiş | 10 | %1 |
| Protokol | 2 | <%1 |
Literatür Kanıt Tablosu
774 yayın, kanıt gücü sırasına göre listelenmiştir. Başlığa tıklayarak künye, mekanizma ve tam özet çekmecesini açabilirsiniz.
| Rejim | Yayın | Yıl | Çalışma tipi | Model | Mekanizma | Özet |
|---|---|---|---|---|---|---|
| Reversible | Horbach et al · Dermatol Surg | 2020 | Randomize Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Transmembran Potansiyel Değişimi | Background: Bleomycin sclerotherapy is ineffective for treating capillary malformations (CMs) because bleomycin cannot adequately be injected into the small-diameter capillary lumina. Electr… |
| Reversible | Hooper et al · Vaccines (Basel) | 2020 | Randomize Klinik Çalışma | İnsan | Gen Elektrotransferi (Plazmid DNA) | Hantaan virus (HTNV) and Puumala virus (PUUV) are pathogenic hantaviruses found in Asia and Europe, respectively. DNA vaccines targeting the envelope glycoproteins of these viruses have been… |
| Reversible | Simeone et al · J Transl Med | 2014 | Randomize Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu, Sistemik / Abskopal İmmün Yanıt | Ipilimumab is the first agent approved for the treatment of advanced melanoma that showed a survival benefit in randomized phase 3 trials. Despite the survival benefit, due to its mechanism … |
| Reversible | Kanat et al · Complement Ther Med | 2013 | Randomize Klinik Çalışma | İnsan | Darbe Parametrelerinin Optimizasyonu | Objective: To evaluate the effectiveness of magnetotherapy in the treatment of hand osteoarthritis (HO). Methods: In this randomized controlled single-blind follow-up study, patients with HO… |
| Reversible | Marty et al · European Journal of Cancer Supplements | 2006 | Randomize Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Electrochemotherapy is an efficient local tumour ablation modality that has already proven its effectiveness clinically in the treatment of various types of tumours. It uses electroporation,… |
| Reversible | C Domenge, S Orlowski, B Luboinski, T Baere, G Schwaab, J Belehradek · Cancer | 1996 | Randomize Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in… |
| Reversible | Altamura et al · International Journal of Clinical Practice | 2026 | Prospektif Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background Electrochemotherapy (ECT) is a nonthermal locoregional treatment that enhances cytotoxic drug uptake through reversible electroporation and is increasingly used across different m… |
| İrreversible | Xiang · J Immunother Cancer | 2026 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Prostate cancer (PCa) is the second most common malignancy in men worldwide. Although radical prostatectomy effectively controls tumor progression, it often causes complications … |
| Reversible | Colletti et al · J Craniomaxillofac Surg | 2025 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Arteriovenous Malformations (AVM) can present themselves in an ample clinical spectrum. They worsen over time, creating local complications such as ulceration, destruction, infection, pain, … |
| İrreversible | Murthy · Cancers (Basel) | 2025 | Prospektif Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: The Canady Helios Cold Plasma (CHCP) system is a non-thermal, non-contact cold atmospheric plasma technology that generates transient electric fields and reactive species capable… |
| İrreversible | Popeneciu · World J Mens Health | 2024 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: To evaluate the morbidity, functional and oncological outcome of irreversible electroporation (IRE) as a focal therapy for prostate cancer (PCa) when used in "active surveillance (A… |
| Reversible | Di Chiacchio et al · J Eur Acad Dermatol Venereol | 2019 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background: Ungual warts are considered the most common benign nail tumour, and they are caused by the human papillomavirus. Despite the numerous treatments reported in the medical literatur… |
| Reversible | Egeland et al · Endosc Int Open | 2018 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Background and study aims: Esophageal cancer is on the rise in the western world and the disease has a poor 5-year survival prognosis below 20 %. Electrochemotherapy is a treatment where a c… |
| Reversible | Groselj et al · Cancer Chemother Pharmacol | 2016 | Prospektif Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | Purpose: With the aim to determine effective therapeutic window of electrochemotherapy, we analyzed bleomycin pharmacokinetic parameters in elderly patients. Methods: In prospective clinical… |
| İrreversible | Thomson et al · J Vasc Interv Radiol | 2011 | Prospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: A single-center prospective nonrandomized cohort study was performed to investigate the safety of irreversible electroporation (IRE) for tumor ablation in humans. Materials and meth… |
| Reversible | Alkis et al · Inorganic Chemistry Communications | 2026 | Klinik Çalışma | İnsan | – | of a niraparib-based Schiff base ligand and its Zn(II)/Ni(II) complexes, and evaluation of electrochemotherapy combined with low-dose ionizing radiation Mehmet Esref Alkis a,*, Yusuf Alan b … |
| Reversible | · – | 2026 | Klinik Çalışma | İnsan | İmmün Kontrol Noktası İnhibitörü Kombinasyonu | The Unmet Need in Solid Tumor Immunotherapy approach combining bacterial outer membrane vesicles (OMVs), nucleic acid nanocarriers, and The advent of immune checkpoint inhibitors and electro… |
| Reversible | Persico et al · JDReAM | 2026 | Klinik Çalışma | İnsan | – | The new therapeutic options now available for patients with hepatocellular carcinoma (HCC) have made their assessment more complex, especially due to the different stages of liver cirrhosis … |
| Reversible | Vos et al · Journal of Clinical Interventional Radiology ISVIR | 2026 | Klinik Çalışma | İnsan | İmmünojenik Hücre Ölümü (ICD) | Locally advanced pancreatic cancer (LAPC) and oligometastatic pancreatic cancer (OMPC) remain associated with poor prognosis despite advances in systemic therapy. In carefully selected patie… |
| İrreversible | Desier et al · Comput Methods Programs Biomed | 2026 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objective: Irreversible electroporation (IRE) represents a promising non-thermal ablation modality for the treatment of deep-seated tumors. However, its clinical efficacy is critically depen… |
| İrreversible | Xia · Prostate Int | 2026 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Prostate cancer (PCa) remains a leading cause of morbidity and mortality among men globally. Irreversible electroporation (IRE), a non-thermal ablation modality, selectively induces tumor ce… |
| Reversible | Abadijoo et al · Sensors and Actuators A: Physical | 2025 | Klinik Çalışma | İnsan | – | od for Intraoperative Cavity Site Margin Therapy Hamed Abadijoo a,b,c , Farshid Rostami Pouria a,b,c,1, Navid Manoochehri a,b,c,1 , Majid Hasanloo a,d, Mohammad Ali Khayamian a,b,c , Hossein… |
| Reversible | Bazancir et al · Eur J Surg Oncol | 2025 | Klinik Çalışma | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Kalsiyum Homeostazının Bozulması | Background: Barrett's esophagus high-grade dysplasia (BE HGD) can transform into esophageal adenocarcinoma (EAC) in 19-28 % of the cases. Calcium electroporation (Ca-EP) is a novel anti-canc… |
| Reversible | Campana et al · Eur J Surg Oncol | 2025 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Background: This study analysed treatment strategies with electrochemotherapy (ECT) in melanoma with limb in-transit metastases (ITM). Methods: We audited AJCC v.8 stage IIIB-IIID patients t… |
| Reversible | Salazar et al · Comput Biol Med | 2025 | Klinik Çalışma | İnsan | Vasküler Kilit (Vascular Lock) Etkisi | The systemic administration of chemotherapeutic drugs involves some reaction and transport mechanisms (RTMs), including perfusion along the blood vessels, extravasation, lymphatic drainage, … |
| İrreversible | Pyrgidis · BJU Int | 2025 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Objective: To compare the perioperative complications of the most common focal therapy (FT) modalities for prostate cancer. Patients and methods: We assessed the GeRmAn Nationwide inpatient … |
| İrreversible | Suberville · Cancers (Basel) | 2025 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background : Irreversible electroporation (IRE) is a novel ablative treatment modality for localized prostate cancer and aims at achieving oncological control while minimizing the related si… |
| İrreversible | Williamson et al · J Vis Exp | 2025 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Electroporation is a promising technology utilizing electrical pulses for macromolecule delivery and soft-tissue ablation, with applications that include next-generation prophylactics and th… |
| İrreversible | Xia · Discov Oncol | 2025 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Prostate cancer is a prevalent condition among older males, with radical prostatectomy being the standard treatment. However, this procedure can inevitably impact urinary and sex… |
| İrreversible | Xiang · BMC Surg | 2025 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Irreversible electroporation (IRE) is a non-thermal ablation technique using high-voltage, low-energy pulses to induce cell membrane perforation and cell death. As an emerging th… |
| İrreversible | Zhang · Prostate Cancer Prostatic Dis | 2024 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Irreversible electroporation (IRE) is a novel technique to treat localized prostate cancer with the aim of achieving oncological control while reducing related side effects. We p… |
| Reversible | Egeland · J Cancer Res Clin Oncol | 2023 | Klinik Çalışma | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi | Purpose: In this study, we aim to investigate gene expression changes in tumor samples obtained from patients with esophageal cancer treated with calcium electroporation. Previously, local t… |
| Reversible | Odeyemi et al · IRJMETS | 2023 | Klinik Çalışma | İnsan | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | Electroporation is the process of temporarily creating openings in the cell membrane by exposing it to a shortterm electric field.In addition to creating openings in the membrane, electropor… |
| Reversible | Rózsa et al · Orv Hetil | 2023 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Introduction: The risk of cutaneous malignancies is significantly higher in immunosuppressed patients compared to the general population. These high-risk skin tumors tend to be aggressive, m… |
| Reversible | Briz et al · Bioelectrochemistry | 2023 | Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi | Electroporation is a phenomenon produced in the cell membrane when it is exposed to high pulsed electric fields that increases its permeability. Among other application fields, this phenomen… |
| İrreversible | Altan · Urol Res Pract | 2023 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Objective: This article reports on the early results of a 1-year follow-up study investigating the efficacy of irreversible electroporation in the treatment of localized prostate cancer. Met… |
| Reversible | Cvetkoska et al · Sci Rep | 2022 | Klinik Çalışma | İnsan | Kas Kasılması ve Anestezi Gereksinimi, İrreversible Por Oluşumu ve Hücre Ölümü | To minimize neuromuscular electrical stimulation during electroporation-based treatments, the replacement of long monophasic pulses with bursts of biphasic high-frequency pulses in the range… |
| Reversible | Egeland · Cancers (Basel) | 2022 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | Calcium electroporation (CaEP) is a novel cancer therapy wherein high intracellular calcium levels, facilitated by reversible electroporation, trigger tumor necrosis. This study aimed to est… |
| Reversible | Marcasciano et al · Eur J Plast Surg | 2022 | Klinik Çalışma | İnsan | – | nline information on a rising low‑invasive procedure, in a constantly aging society Marco Marcasciano1 · Juste Kaciulyte2,3 · Riccardo Di Giuli4 · Jacopo Nanni2 · Jacopo Maria Frattaroli2 · … |
| Reversible | Szlasa et al · Int J Mol Sci | 2021 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu | Electroporation is influenced by the features of the targeted cell membranes, e.g., the cholesterol content and the surface tension of the membrane. The latter is eventually affected by the … |
| Reversible | Groselj et al · Pharmaceutics | 2021 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | The plasma concentration profile of bleomycin in the distribution phase of patients younger than 65 years is needed to determine the suitable time interval for efficient application of elect… |
| İrreversible | Al-Leswas et al · British Journal of Surgery | 2021 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background The present systematic review aimed to summarise the available evidence on indications and oncological outcomes after MA IRE for stage III pancreatic cancer (PC). Methods A litera… |
| İrreversible | Aycock et al · IEEE Trans Biomed Eng | 2021 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Unlabelled: High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay (d 1 )-negative phas… |
| İrreversible | Buijs et al · Diagn Interv Radiol | 2021 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: Ablation plays a growing role in the treatment of small renal masses (SRMs) due to its nephron sparing properties and low invasiveness. Irreversible electroporation (IRE) has the po… |
| İrreversible | Wah · Eur Radiol | 2021 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: To evaluate the safety and efficacy of CT-guided IRE of clinical T1a (cT1a) renal tumours close to vital structures and to assess factors that may influence the technical success… |
| Reversible | Pirc et al · Clin Ther | 2020 | Klinik Çalışma | İnsan | – | Purpose: Electrochemotherapy is increasingly entering into national and international guidelines, requiring formal evaluation of treatment costs and cost-effectiveness to ensure that its upt… |
| Reversible | Tartaglia et al · Clin Exp Dent Res | 2020 | Klinik Çalışma | İnsan | – | Objective(s): It is well appreciated that traditional analgesic delivery routes used to treat pain associated with temporomandibular disorder (TMD) often have harmful unintended side effects… |
| İrreversible | Go et al · Cancers (Basel) | 2020 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, İmmünojenik Hücre Ölümü (ICD) | Recently, cancer immunotherapy has received attention as a viable solution for the treatment of refractory tumors. However, it still has clinical limitations in its treatment efficacy due to… |
| İrreversible | Lundy et al · The American Surgeon™ | 2019 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | A 69-year-old female with a complex past medical history notable for hypertension, vascular disease with history of bilateral aortoiliac bypass and renal endarterectomy, 49-year smoking hist… |
| Reversible | Hristov et al · Biochim Biophys Acta Biomembr | 2018 | Klinik Çalışma | İnsan | Nanosaniye Darbeli Elektrik Alan (nsPEF), Reversible Membran Permeabilizasyonu | We compared membrane permeabilization by nanosecond pulsed electric field (nsPEF) in HEK293 cells with and without assembled CaV1.3 L-type voltage-gated calcium channel (VGCC). Individual ce… |
| Reversible | Romeo et al · Technol Cancer Res Treat | 2018 | Klinik Çalışma | İnsan | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Darbe Parametrelerinin Optimizasyonu | Reversible electroporation is used to increase the uptake of chemotherapeutic drugs in local tumor treatment (electrochemotherapy) by applying the pulsing protocol (8 rectangular pulses, 100… |
| Reversible | Grošelj et al · Clinical Therapeutics | 2017 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Few studies have assessed concentrations of fatty acid ethyl esters (FAEEs) after controlled administration of wide range of alcohol doses in both genders. The objective was to assess the ti… |
| İrreversible | Canvasser et al · World J Urol | 2017 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose: To report on the first short-term oncologic outcomes of percutaneous irreversible electroporation for small renal masses. Methods: Patients with cT1a renal masses treated with irrev… |
| İrreversible | Zhang et al · Pancreas | 2017 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Zhang, Yishi MD; Shi, Juanjuan MD; Zeng, Jianying MS; Alnagger, Mohammed MD; Zhou, Liang MD; Fang, Gang MD; Long, Xin'an MD; Pan, Zhongbao MD; Li, Yanhong BN; Chen, Jibing PhD; Xu, Kecheng M… |
| Reversible | Mir-Bonafé et al · Actas Dermosifiliogr | 2015 | Klinik Çalışma | İnsan | Nekroz ve Nekroptoz | Introduction and objectives: Electrochemotherapy is indicated for the treatment of unresectable cutaneous and subcutaneous tumors. The technique involves the synergistic use of electroporati… |
| Reversible | Quaglino et al · Acta Oncol | 2015 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | Background: Electrochemotherapy describes the use of electric pulses to enhance chemotherapy uptake, and has proven highly efficient in treating cutaneous metastases. Patients referred for e… |
| İrreversible | Trimmer et al · J Vasc Interv Radiol | 2015 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: To evaluate whether irreversible electroporation (IRE) can be used as an ablation technique for small renal tumors (T1a cancers or small benign tumors) and to describe features afte… |
| İrreversible | Wagstaff et al · BMC Cancer | 2015 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Electroporation is a novel treatment technique utilizing electric pulses, traveling between two or more electrodes, to ablate targeted tissue. The first in human studies have pro… |
| Reversible | Castiello et al · IEEE Trans. Dielect. Electr. Insul. | 2014 | Klinik Çalışma | İnsan | – | Electrochemotherapy (ECT) is a local anticancer treatment for superficial tumors which involves the administration of a chemotherapeutic drug followed by short, high-voltage pulses. Incipien… |
| Reversible | O'Brien et al · J Immunother Cancer | 2014 | Klinik Çalışma | İnsan | – | Meeting abstracts The correlation between the level of immune involvement and immune cell infiltration within a treated tumour and the clinical outcome for patients has been well established… |
| İrreversible | Nielsen et al · Br J Anaesth | 2014 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background Irreversible electroporation (IRE) is a novel tumour ablation technique involving repetitive application of electrical energy around a tumour. The use of pulsed electrical gradien… |
| Reversible | Marandola et al · WJA | 2013 | Klinik Çalışma | İnsan | – | Electrochemotherapy and heart function: Treatment in a patient with implantable cardioverter defibrillator/pace-maker |
| Reversible | Pavliha et al · J Membr Biol | 2013 | Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Electroporation-based treatment combining high-voltage electric pulses and poorly permanent cytotoxic drugs, i.e., electrochemotherapy (ECT), is currently used for treating superficial tumor… |
| Reversible | Shankayi et al · J Membr Biol | 2013 | Klinik Çalışma | İnsan | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | During standard electrochemotherapy (ECT), using a train of 1,000 V/cm amplitude rectangular pulses with 1 Hz frequency, patients experience an unpleasant sensation and slight edema. Accordi… |
| Reversible | Diaz et al · J Transl Med | 2013 | Klinik Çalışma | İnsan | Gen Elektrotransferi (Plazmid DNA) | Background: DNA electroporation has been demonstrated in preclinical models to be a promising strategy to improve cancer immunity, especially when combined with other genetic vaccines in het… |
| Reversible | Gavazza et al · Hum Gene Ther | 2013 | Klinik Çalışma | İnsan | – | Client-owned pet dogs represent exceptional translational models for advancement of cancer research because they reflect the complex heterogeneity observed in human cancer. We have recently … |
| Reversible | Dotsinsky et al · Biotechnology & Biotechnological Equipment | 2012 | Klinik Çalışma | İnsan | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy is based on electroporation, which creates aqueous pathways in the cell membrane as a result of applied short intensive electric field usually generated by high voltage e… |
| Reversible | Skarlatos et al · In Vivo | 2011 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy is currently undergoing intensive investigation in the field of local control of cancer. In Greece, five medical centers have co-operated to perform ECT for the efficient… |
| Reversible | Napotnik et al · Bioelectromagnetics | 2011 | Klinik Çalışma | İnsan | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | Nanosecond, high-voltage electric pulses (nsEP) induce permeabilization of the plasma membrane and the membranes of cell organelles, leading to various responses in cells including cytochrom… |
| Reversible | Laufer et al · Physiol Meas | 2010 | Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | The four-electrode method was used to measure the ex vivo complex electrical impedance of tissues from 14 hepatic tumors and the surrounding normal liver from six patients. Measurements were… |
| Reversible | Corovic et al · Biomed Eng Online | 2009 | Klinik Çalışma | İnsan | Elektrik Alan Dağılımı ve Modellemesi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background: Electrochemotherapy is an effective approach in local tumour treatment employing locally applied high-voltage electric pulses in combination with chemotherapeutic drugs. In plann… |
| Reversible | Vernier et al · PLoS One | 2009 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | Reversible electropermeabilization (electroporation) is widely used to facilitate the introduction of genetic material and pharmaceutical agents into living cells. Although considerable know… |
| Reversible | Guida et al · European Journal of Cancer Supplements | 2008 | Klinik Çalışma | İnsan | – | ECT is an effective local treatment for palliation on inoperable superficial neoplastic localizations which combines surgical debulking had a disease control for a long period (8 months, med… |
| Reversible | Tauceri et al · Langenbecks Arch Surg | 2008 | Klinik Çalışma | İnsan | – | Background and aims: Survival rates of patients with stage IV melanoma are poor: Median survival is 7-8 months and 5-year survival rates about 5%. There is no agreement on the role of surger… |
| Reversible | Pavlovic et al · IEEE Trans Inf Technol Biomed | 2007 | Klinik Çalışma | İnsan | – | Many branches of the healthcare industry are being influenced by information and communication technology (ICT). Clinical trials are not an exception. Despite this fact, more than 75% of cli… |
| Reversible | Zupanic et al · Neoplasma | 2007 | Klinik Çalışma | İnsan | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | Involuntary muscle contractions and painful sensations during electric pulse delivery are the most unpleasant side effects of electrochemotherapy. The aim of this study was to determine the … |
| İrreversible | Esser et al · Technol Cancer Res Treat | 2007 | Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Local and drug-free tissue treatment by irreversible electroporation (IRE) involves the creation of aqueous pores in a cell's plasma membrane (PM) and leads to non-thermal cell death by necr… |
| Reversible | Mir · European Journal of Cancer Supplements | 2006 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy is defined as the local potentiation, by means of permeabilizing electric pulses, of the antitumour activity of a non-permeant (or a low-permeant) anticancer drug possess… |
| Reversible | Mir et al · European Journal of Cancer Supplements | 2006 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | structions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrod… |
| İrreversible | Davalos et al · Ann Biomed Eng | 2005 | Klinik Çalışma | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | This study introduces a new method for minimally invasive treatment of cancer-the ablation of undesirable tissue through the use of irreversible electroporation. Electroporation is the perme… |
| Reversible | Spugnini et al · J Exp Clin Cancer Res | 2003 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | The objectives of this phase I/II study were: i) to determine whether electrochemotherapy (intralesional bleomycin + electric pulses) could be effective in companion animals with different, … |
| Reversible | Vernier et al · Biochem Biophys Res Commun | 2003 | Klinik Çalışma | İnsan | Apoptoz İndüksiyonu, Nanosaniye Darbeli Elektrik Alan (nsPEF) | We report here real-time imaging of calcium bursts in human lymphocytes exposed to nanosecond, megavolt-per-meter pulsed electric fields. Ultra-short (less than 30 ns), high-field (greater t… |
| Reversible | Cemazar et al · Br J Cancer | 2001 | Klinik Çalışma | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Recent studies have indicated that the antitumour effectiveness of electrochemotherapy, a combination of chemotherapeutic drugs with application of high voltage electric pulses applied to th… |
| Reversible | Daskalov et al · IEEE Eng Med Biol Mag | 1999 | Klinik Çalışma | İnsan | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | Electrochemotherapy using rectangular biphasic stimuli and bursts of stimuli, as compared to using monophasic pulses obtained by capacitor discharge, are at least of the same efficacy. The u… |
| Reversible | Serša et al · Eur J Cancer | 1998 | Klinik Çalışma | İnsan | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | This study was aimed at assessing the response to electrochemotherapy with cisplatin of cutaneous tumour nodules in patients with malignant melanoma, squamous cell carcinoma and basal cell c… |
| Reversible | Garner et al · IEEE Eng. Med. Biol. Mag. | 1996 | Klinik Çalışma | İnsan | Gen Elektrotransferi (Plazmid DNA) | Although electroporation in the past has mainly been used as a research tool, recent work has demonstrated its potential for clinical applications. Some of the areas explored include electro… |
| Reversible | Narayanan · Curr Oncol | 2025 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The purpose was to determine the ability of 18-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) scans performed within 24 h of percutaneous image-guided… |
| İrreversible | Narayanan · Cardiovasc Intervent Radiol | 2024 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: Demonstrating the safety and efficacy of percutaneous irreversible electroporation (IRE) for the treatment of lymph node metastases. Materials and methods: An IRB-approved, single-c… |
| İrreversible | Wang et al · BMC Cancer | 2021 | Retrospektif Klinik Çalışma | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: To evaluate the clinical efficacy and safety of ablating renal cell carcinoma (RCC) by irreversible electroporation (IRE). Methods: Fifteen patients (19 lesions) with RCC who und… |
| İrreversible | Ozdemir Simsek et al · BMC Anesthesiol | 2026 | Vaka Serisi | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: Irreversible electroporation is a novel, non-thermal tumor ablation technique that induces cell death through electrical disruption of cellular membranes while preserving surroun… |
| Reversible | Bonura et al · Diseases | 2025 | Vaka Serisi | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background/objectives: Gastric cancer often presents at advanced stages with complications such as iron-deficiency anemia (IDA) due to chronic bleeding, representing a significant global hea… |
| Reversible | Lampreht Tratar et al · Front Vet Sci | 2026 | Vaka Raporu | İnsan | Elektrot Geometrisi ve Yerleşimi, İnterlökin-12 Aracılı İmmün Uyarım | Electrochemotherapy (ECT) combined with gene electrotransfer of interleukin-12 (IL-12 GET) has shown promising results in the treatment of canine mast cell tumors (MCTs). However, when tumor… |
| Reversible | A Šenk Juh, B Šenk, M Čemažar · Medicinski razgledi | 2026 | Vaka Raporu | İnsan | – | – Amadej Šenk Juh, Barbara Šenk, Maja Čemažar 99 Diagnostični izziv 99 Diagnostic Challenge 105 Seznam diplomantov 105 List of Graduated Students 107 Navodila avtorjem 113 Guidelines for Aut… |
| Reversible | Rózsa et al · J Dermatolog Treat | 2025 | Vaka Raporu | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Purpose: Lentigo maligna (LM), lentigo maligna melanoma (LMM), and acral lentiginous melanoma (ALM) are characterized by irregular borders and manifest on highly visible and/or surgically ch… |
| İrreversible | Araújo et al · J Cardiothorac Vasc Anesth | 2025 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Anesthesia for Irreversible Electroporation in Patients with a Pacemaker Guilherme Freitas Ara ujo, MD, TSA*, Marcelo Froeder Arcuri, MDy, Veronica Neves Fialho Queiroz, MD, PhD*, Guilherme… |
| Reversible | Caprino et al · J Surg Case Rep | 2021 | Vaka Raporu | İnsan | – | Recurrence of rectal cancer (RRC) affects up to one-third of patients. The survival is strictly dependent on the possibility of performing surgery without microscopic tumor residues (R0). El… |
| Reversible | Spugnini et al · Open Vet J | 2016 | Vaka Raporu | İnsan | Sisplatin Hücre İçi Birikiminin Artması | An eleven-year-old stallion was referred for adjuvant treatment of an incompletely excised, recurring penile fibrosarcoma. The horse was bright, alert and responsive with a 15 x 12 cm ulcera… |
| İrreversible | Harris et al · J Pediatr Hematol Oncol | 2016 | Vaka Raporu | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) induces apoptosis in tumor cells with electric energy, allowing treatment of unresectable tumors. One potential application is metastatic osteosarcoma (OS)… |
| Reversible | Daniels et al · PLoS One | 2011 | Vaka Raporu | İnsan | Kas Kasılması ve Anestezi Gereksinimi | Pulsed electric fields (PEF) have become an important minimally invasive surgical technology for various applications including genetic engineering, electrochemotherapy and tissue ablation. … |
| Reversible | Tian et al · J Cancer Res Ther | 2026 | Sistematik Derleme / Meta-Analiz | İnsan | – | Background: Pulsed electric field (PEF) ablation is a promising nonthermal tumor treatment for liver cancer, recognized for its ability to induce immune responses. However, the field has lac… |
| Reversible | Formstone et al · Eur Radiol | 2026 | Sistematik Derleme / Meta-Analiz | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Objectives: To systematically review the available evidence on electrochemotherapy (ECT) in pediatric patients, focusing on indications, treatment parameters, efficacy, and safety. Materials… |
| İrreversible | Cheng · Transl Androl Urol | 2025 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Focal irreversible electroporation (IRE) has shown promising initial oncological and functional outcomes in the treatment of localised prostate cancer (PCa), although robust evid… |
| İrreversible | Tay · Prostate Cancer Prostatic Dis | 2025 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: Focal Therapy (FT) is a treatment option for the treatment of limited volume clinically significant prostate cancer (csPCa). We aim to systematically review outcomes of establi… |
| İrreversible | Zhang · World J Mens Health | 2025 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: Irreversible electroporation (IRE) is a promising alternative treatment for low-intermediate-risk localized prostate cancer. In this systematic review we aim to evaluate the safety … |
| İrreversible | Prabhakar · Indian J Urol | 2024 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: Irreversible electroporation (IRE) is a new and promising focal therapy for the treatment of localized prostate cancer. In this systematic review, we summarize the literature o… |
| İrreversible | Xia · Discov Oncol | 2024 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Focal therapy, a minimally invasive strategy for localized prostate cancer, has been widely employed in the targeted treatment of localized prostate cancer in recent years. We analyzed 1312 … |
| Reversible | Ferioli et al · Curr Oncol | 2023 | Sistematik Derleme / Meta-Analiz | İnsan | – | Radiotherapy (RT) and electrochemotherapy (ECT) are established local treatments for cancer. While effective, both therapies have limitations, especially in treating bulky and poorly oxygena… |
| İrreversible | Hogenes · Technol Cancer Res Treat | 2023 | Sistematik Derleme / Meta-Analiz | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması, Reversible Membran Permeabilizasyonu | Introduction: The aim of this study was to review the effect of irreversible electroporation parameter settings on the size of the ablation zone and the occurrence of thermal effects. This i… |
| Reversible | Potočnik et al · Pharmaceutics | 2022 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | Gen Elektrotransferi (Plazmid DNA) | The exact mechanisms of nucleic acid (NA) delivery with gene electrotransfer (GET) are still unknown, which represents a limitation for its broader use. Further, not knowing the effects that… |
| Reversible | Granata et al · Int J Environ Res Public Health | 2021 | Sistematik Derleme / Meta-Analiz | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Imaging methods and the most appropriate criteria to be used for detecting and evaluating response to oncological treatments depend on the pathology and anatomical site to be tre… |
| İrreversible | Agnass et al · Int J Hyperthermia | 2020 | Sistematik Derleme / Meta-Analiz | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | Introduction: Irreversible electroporation (IRE) is a relatively new ablation method for the treatment of unresectable cancers. Although the main mechanism of IRE is electric permeabilizatio… |
| Reversible | Cen et al · J Healthc Eng | 2017 | Sistematik Derleme / Meta-Analiz | İnsan | Sinir ve Damar Yapılarının Korunması, Elektrot Geometrisi ve Yerleşimi | Pulsed electric field treatment is now widely used in diverse biological and medical applications: gene delivery, electrochemotherapy, and cancer therapy. This minimally invasive technique h… |
| İrreversible | Valerio et al · Eur Urol | 2017 | Sistematik Derleme / Meta-Analiz | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Context: Focal therapy of prostate cancer has been proposed as an alternative to whole-gland treatments. Objective: To summarize the evidence regarding sources of energy employed in focal th… |
| Reversible | Campana et al · Radiol Oncol | 2016 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | – | Background: Electrochemotherapy is becoming a well-established treatment for malignancies of skin and non-skin origin and its use is widening across Europe. The technique was developed and o… |
| Reversible | Weber et al · BMC Musculoskelet Disord | 2015 | Sistematik Derleme / Meta-Analiz | İnsan | – | Background: Physical therapy for the treatment of lateral epicondylitis (LE) often comprises movement therapies, extracorporeal shockwave therapy (ECSWT), low level laser therapy (LLLT), low… |
| Reversible | Mali et al · Radiol Oncol | 2013 | Sistematik Derleme / Meta-Analiz | Literatür Analizi | Elektrik Alan Dağılımı ve Modellemesi | Background: Electrochemotherapy (ECT) is an effective and safe method for local treatment of tumors. However, relatively large variability in effectiveness of ECT has been observed, which li… |
| Reversible | Mali et al · Eur J Surg Oncol | 2013 | Sistematik Derleme / Meta-Analiz | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Background: This systematic review has two purposes: to consolidate the current knowledge about clinical effectiveness of electrochemotherapy, a highly effective local therapy for cutaneous … |
| Reversible | Arai et al · Gastro Hep Adv | 2026 | Derleme | Literatür Analizi | – | Gastro Hep Advances 2026;5:100916 RESEARCH LETTER ElectroporationInduced Gastric Cancer Models Through EpithelialSpecific Genetic Modifications G astric cancer remains a major global health … |
| Reversible | Cai et al · Adv Mater | 2026 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Mitokondriyal Disfonksiyon ve Oksidatif Stres | Inspired by endogenous physiological electric fields, electro-mediated therapeutic strategies represent promising approaches for targeted cancer therapy owing to their deep tissue penetratio… |
| Reversible | Liu et al · Int. J. Extrem. Manuf. | 2026 | Derleme | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Microneedles (MNs) have emerged as a transformative minimally invasive platform in biomedicine, enabling painless transdermal drug delivery and diagnostic applications. However, conventional… |
| Reversible | Saeed et al · J Control Release | 2026 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrik Alan Dağılımı ve Modellemesi | Tissue penetration of anticancer drugs is hindered by adverse biophysical properties of solid tumors, including elevated interstitial fluid pressure, dense extracellular matrices, and abnorm… |
| Reversible | Shi et al · Front Oncol | 2026 | Derleme | Literatür Analizi | İmmünojenik Hücre Ölümü (ICD), İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Tumor Treating Fields (TTFields) and pulsed electric fields (PEF) have emerged as a fourth modality in oncological treatment, succeeding surgery, radiotherapy, and pharmacotherapy. However, … |
| Reversible | Truong et al · Biomater Res | 2026 | Derleme | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Reversible Membran Permeabilizasyonu | Electric field-based therapies are rapidly emerging as innovative modalities in the fight against cancer, offering targeted, minimally invasive, and often immunomodulatory alternatives to co… |
| Reversible | Liu et al · Adv Drug Deliv Rev | 2026 | Derleme | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Termal Etki ve Joule Isınması | Intracellular delivery of therapeutic biomolecules represents a fundamental prerequisite for cell-based therapies and precision medicine, yet existing delivery methods present critical limit… |
| İrreversible | Gehl et al · Radiol Oncol | 2026 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The field of oncology has witnessed remarkable progress with the integration of high-tech innovations in tumor ablation. Tumor ablation therapies, such as radiofrequency ablation (RFA), micr… |
| İrreversible | Hossain · – | 2026 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | v LIST OF TABLES ......................................................................................................................... vi LIST OF FIGURES ................................… |
| İrreversible | Ji et al · Small | 2026 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Electroporation has evolved from a membrane-permeabilization method into a versatile therapeutic platform for intracellular delivery, locoregional tumor intervention, and bioelectrically reg… |
| İrreversible | Liu · Prostate Int | 2026 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Prostate cancer (PCa) is the second most commonly diagnosed malignancy in men. Radical treatments such as radical prostatectomy and radiotherapy can be associated with morbidity that impact … |
| İrreversible | Mandija et al · J Magn Reson Imaging | 2026 | Derleme | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi | Magnetic resonance imaging (MRI) has emerged as a noninvasive technique for probing the electrical properties of biological tissues: electrical conductivity and relative permittivity. This r… |
| İrreversible | Miklavčič · Bioelectrochemistry | 2026 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Electroporation has birthed two massive parallel universes of applications: medicine and food processing. Despite operating on the same fundamental physics, these fields fail to crosspollina… |
| İrreversible | Roldan-Testillano · Prostate Int | 2026 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Focal therapy (FT) has emerged as a promising treatment option for localized prostate cancer (PCa), offering oncologic control with reduced adverse effects compared to radical therapies. Var… |
| Reversible | Lu et al · Pacing Clin Electrophysiol | 2025 | Derleme | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Kalsiyum Homeostazının Bozulması | Background: Contact force (CF)-dependent pulse field electroporation (PFE) may generate tissue heating, affecting junctional rhythm at the triangle of Koch (ToK) in a clinical setting. PFE m… |
| Reversible | Morozas et al · Biomed Pharmacother | 2025 | Derleme | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) is a popular clinical anticancer treatment modality that combines chemotherapy with electroporation to enhance drug uptake by tumor cells. One of its key advantages… |
| Reversible | Szewczyk et al · Biochim Biophys Acta Rev Cancer | 2025 | Derleme | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi | Calcium electroporation, an innovative technique, uses high-voltage pulses to introduce calcium ions into cells, leading to cell death and tumor growth inhibition. This review explores the p… |
| Reversible | Yun · Radiol Adv | 2025 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Minimally invasive image-guided tumor ablation techniques have been established as safe, effective methods to treat a variety of unresectable soft tissue tumors. Standard thermal ablation me… |
| Reversible | Jesenko · Radiol Oncol | 2025 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Background: Gene therapy has emerged as a transformative biomedical approach, offering new therapeutic possibilities from many so far uncurable diseases through the introduction of recombina… |
| Reversible | Wang et al · Biochim Biophys Acta Rev Cancer | 2025 | Derleme | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Cancer is a significant health issue impacting humans. Currently, systemic therapies such as chemotherapy have significantly increased the life expectancy of cancer patients. However, some p… |
| Reversible | Yu et al · Biochim Biophys Acta Rev Cancer | 2025 | Derleme | Hayvan (İn Vivo) | Sistemik / Abskopal İmmün Yanıt, Reversible Membran Permeabilizasyonu | Percutaneous tumor ablation is a minimally invasive treatment for tumors. The release of tumor neoantigens after ablation not only remodels the local tumor microenvironment, but also achieve… |
| Reversible | Ferioli et al · Technol Cancer Res Treat | 2025 | Derleme | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | This narrative review explores the potential role of electrochemotherapy (ECT) in treating anorectal tumors, focusing on its effectiveness, feasibility, and associated toxicities. ECT, which… |
| İrreversible | Chikovani et al · Vaccines (Basel) | 2025 | Derleme | Literatür Analizi | İmmünojenik Hücre Ölümü (ICD), İrreversible Por Oluşumu ve Hücre Ölümü | Cancer immunotherapy has redefined oncology's goals, aiming for durable systemic immunity rather than mere cytoreduction. However, many solid tumors remain refractory due to immunosuppressiv… |
| İrreversible | Hernandez · Front Urol | 2025 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Focal therapy (FT) for localized prostate cancer (PCa) has evolved into a precision-based alternative to radical treatments, aiming to eradicate clinically significant disease while minimizi… |
| İrreversible | Vallin et al · Annu Rev Chem Biomol Eng | 2025 | Derleme | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a nonthermally mediated tissue ablation modality that makes use of short pulsed electric fields to destroy cancerous lesions in situ. In the past two de… |
| Reversible | Shiwani et al · Br J Radiol | 2024 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Reversible electroporation (EP) refers to the use of high-voltage electrical pulses on tissues to increase cell membrane permeability. It allows targeted delivery of high concentrations of c… |
| Reversible | Taghdiri et al · Int J Mol Sci | 2024 | Derleme | Hayvan (İn Vivo) | – | Clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has revolutionized the field of gene therapy as it has enabled precise genom… |
| Reversible | Universitat des Saarlandes · – | 2024 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması | mit intravenöser Verabreichung von Bleomycin, Oxaliplatin und Oxaliplatin in Kombination mit Bevacizumab zur Behandlung von hepatischen Metastasen des kolorektalen Karzinoms im Rattenmodell … |
| Reversible | Zhou et al · Adv Sci (Weinh) | 2024 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Intracellular delivery of nano-drug-carriers (NDC) to specific cells, diseased regions, or solid tumors has entered the era of precision medicine that requires systematic knowledge of nano-b… |
| Reversible | Ferioli et al · Curr Oncol | 2024 | Derleme | Hayvan (İn Vivo) | Sistemik / Abskopal İmmün Yanıt, İmmünojenik Hücre Ölümü (ICD) | Electrochemotherapy (ECT) is an emerging therapeutic approach gaining growing interest for its potential immunomodulatory effects in cancer treatment. This narrative review systematically ex… |
| Reversible | Hadzialjevic et al · Front Immunol | 2024 | Derleme | İnsan | İmmünojenik Hücre Ölümü (ICD), Sistemik / Abskopal İmmün Yanıt | Electrochemotherapy is a novel, locoregional therapy that is used to treat cutaneous and deep-seated tumors. The electric pulses used in electrochemotherapy increase the permeability of the … |
| Reversible | Aveta · Life (Basel) | 2024 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | This review focuses on ablative techniques for small renal masses (SRMs), including radiofrequency ablation (RFA), cryoablation (CA), microwave ablation (MWA), and irreversible electroporati… |
| İrreversible | De Cillis et al · IEEE J. Electromagn. RF Microw. Med. Biol. | 2024 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | The adoption of high-frequency irreversible electroporation in various medical treatments is becoming increasingly prevalent. There is currently a special focus on its applications in oncolo… |
| İrreversible | Faiella · J Pers Med | 2024 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | We evaluated the most recent research from 2000 to 2023 in order to deeply investigate the applications of PCa IRE, first exploring its usage with primary intent and then salvage intent. Fin… |
| İrreversible | Lazarovich · Transl Cancer Res | 2024 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background and objective: The role of focal therapy in the treatment of localized prostate cancer is evolving. However, despite accumulating evidence, current guidelines and regulatory bodie… |
| İrreversible | Zhao · Phenomics | 2024 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Pyroptosis is a newly recognized type of programmed cell death mediated by the gasdermin family and caspase. It is characterized by the formation of inflammasomes and the following inflammat… |
| Reversible | Brno University of Technology · – | 2023 | Derleme | Literatür Analizi | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | Electroporation utilizes high-intensity voltage pulses to permeabilize the cell membranes, serving as a staple technique across biotechnology and medicine. While the primary mechanism - pore… |
| Reversible | Campana et al · Cancers (Basel) | 2023 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The 4th World Congress of Electroporation (Copenhagen, 9-13 October 2022) provided a unique opportunity to convene leading experts in pulsed electric fields (PEF). PEF-based therapies harnes… |
| Reversible | Ottlakan et al · Electrochem | 2023 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) has evolved significantly during the last decade, expanding treatment indications from superficial skin lesions to advanced-stage, deep-seated tumors in hard-to-rea… |
| Reversible | Qian et al · Biomed Tech (Berl) | 2023 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Objectives: Electroporation, the breakdown of the biomembrane induced by external electric fields, has increasingly become a research hotspot for its promising related methods in various kin… |
| İrreversible | Peng et al · Adv Healthc Mater | 2023 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | In this work, we proposed nµPEF, a novel pulse configuration combining nanosecond and microsecond pulses (nµPEF), to enhance tumor ablation in irreversible electroporation (IRE) for oncologi… |
| Reversible | Condello et al · Cancers (Basel) | 2022 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) is one of the innovative strategies to overcome the multi drug resistance (MDR) that often occurs in cancer. Resistance to anticancer drugs results from a variety o… |
| Reversible | Tsoneva et al · Biophys Chem | 2022 | Derleme | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | This review focuses on electrochemotherapy that consists in the delivery of anti-cancer drugs using high-voltage electrical pulses. Technical issues, choice of drugs, and protocol of drug de… |
| Reversible | Bendix et al · Eur J Surg Oncol | 2022 | Derleme | İnsan | Sistemik / Abskopal İmmün Yanıt | Electrochemotherapy (ECT), the application of an electric impulse to deliver chemotherapy drugs into cells, has been in clinical trials since the early 1990s and has been used for a variety … |
| Reversible | Das et al · Front Bioeng Biotechnol | 2022 | Derleme | Literatür Analizi | İmmünojenik Hücre Ölümü (ICD) | Immunotherapy is becoming a very common treatment for cancer, using approaches like checkpoint inhibition, T cell transfer therapy, monoclonal antibodies and cancer vaccination. However, the… |
| İrreversible | Gong · Vaccines (Basel) | 2022 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Apoptoz İndüksiyonu | Electroporation is the process of instantaneously increasing the permeability of a cell membrane under a pulsed electric field. Depending on the parameters of the electric pulses and the tar… |
| İrreversible | Tasu et al · Diagn Interv Imaging | 2022 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Thermal tumor ablation techniques including radiofrequency, microwave, LASER, high-intensity focused ultrasound and cryoablation are routinely used to treated liver, kidney, bone, or lung tu… |
| İrreversible | Wang · Front Oncol | 2022 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Pulsed field ablation can increase membrane permeability and is an emerging non-thermal ablation. While ablating tumor tissues, electrical pulses not only act on the membrane structure of ce… |
| İrreversible | Zhang et al · Front Immunol | 2022 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE), a novel non-thermal ablation technique, is utilized to ablate unresectable solid tumors and demonstrates favorable safety and efficacy in the clinic. IRE … |
| Reversible | Aguilar et al · Cancers (Basel) | 2021 | Derleme | Literatür Analizi | Elektrik Alan Dağılımı ve Modellemesi | The biological impact of exogenous, alternating electric fields (AEFs) and direct-current electric fields has a long history of study, ranging from effects on embryonic development to influe… |
| Reversible | Balantič et al · Acta Chim Slov | 2021 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Electroporation is used to increase the permeability of the cell membrane through high-voltage electric pulses. Nowadays, it is widely used in different areas, such as medicine, biotechnolog… |
| Reversible | Bonferoni et al · Cancers (Basel) | 2021 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Surgical resection is the gold standard for the treatment of many kinds of tumor, but its success depends on the early diagnosis and the absence of metastases. However, many deep-seated tumo… |
| Reversible | Hur et al · Adv Sci (Weinh) | 2021 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA) | Innate cell function can be artificially engineered and reprogrammed by introducing biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the cytosol or nucleus. T… |
| Reversible | Luz et al · Vaccines (Basel) | 2021 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique… |
| Reversible | Batista Napotnik et al · Bioelectrochemistry | 2021 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Exposure of cells to high voltage electric pulses increases transiently membrane permeability through membrane electroporation. Electroporation can be reversible and is used in gene transfer… |
| Reversible | Sersa et al · Eur J Surg Oncol | 2021 | Derleme | İnsan | Ekstraselüler Matriks ve Doku İskeletinin Korunması | The beneficial effects of electrochemotherapy (ECT) for superficial tumours and, more recently, deep-seated malignancies in terms of local control and quality of life are widely accepted. Ho… |
| Reversible | Brock et al · Front Oncol | 2020 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | New therapeutic strategies and paradigms are direly needed for the treatment of cancer. While the surgical removal of tumors is favored in most cancer treatment plans, resection options are … |
| Reversible | Graybill et al · Cancers (Basel) | 2020 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the trea… |
| Reversible | Pakhomov et al · Bioelectrochemistry | 2020 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | Conventional electric stimuli of micro- and millisecond duration excite or activate cells at voltages 10-100 times below the electroporation threshold. This ratio is remarkably different for… |
| Reversible | Gantenbein et al · Front Bioeng Biotechnol | 2020 | Derleme | Literatür Analizi | Gen Elektrotransferi (Plazmid DNA) | Viral carrier transport efficiency of gene delivery is high, depending on the type of vector. However, viral delivery poses significant safety concerns such as inefficient/unpredictable repr… |
| Reversible | Dermol-Černe et al · Expert Opin Drug Deliv | 2020 | Derleme | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Introduction : Skin electroporation is a promising treatment for transdermal drug delivery, gene electrotransfer, skin rejuvenation, electrochemotherapy, and wound disinfection. Although a c… |
| Reversible | Frandsen et al · Cancers (Basel) | 2020 | Derleme | Literatür Analizi | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Sistemik / Abskopal İmmün Yanıt | Calcium electroporation is a potential novel anti-cancer treatment where high calcium concentrations are introduced into cells by electroporation, a method where short, high voltage pulses i… |
| İrreversible | Geboers et al · Radiology | 2020 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). HVE… |
| Reversible | Cemazar et al · Bioelectricity | 2019 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Electrochemotherapy is gaining recognition as an effective local therapy that uses systemically or intratumorally injected bleomycin or cisplatin with electroporation as a delivery system th… |
| Reversible | Nuccitelli · Bioelectricity | 2019 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | This review covers the use of pulsed electric fields in cancer therapy. It is organized into three sections based on pulse length, millisecond domain, microsecond domain, and nanosecond doma… |
| Reversible | Sokołowska et al · Int J Mol Sci | 2019 | Derleme | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi | The gene delivery to skeletal muscles is a promising strategy for the treatment of both muscular disorders (by silencing or overexpression of specific gene) and systemic secretion of therape… |
| Reversible | Esmaeili et al · J Healthc Eng | 2019 | Derleme | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | The efficiency of electroporation (EP) has made it a widely used therapeutic procedure to transfer cell killing substances effectively to the target site. A lot of researches are being done … |
| İrreversible | Chen · Technol Cancer Res Treat | 2019 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Irreversible electroporation has raised great interest in the past decade as a means of destroying cancers in a way that does not involve heat. Irreversible electroporation is a novel ablati… |
| Reversible | Batista Napotnik et al · Bioelectrochemistry | 2018 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Doku İletkenliği ve Empedans Değişimi | Exposing cells to an electric field leads to electroporation of the cell membrane which has already been explored and used in a number of applications in medicine and food biotechnology (e.g… |
| Reversible | Probst et al · Technol Cancer Res Treat | 2018 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Electroporation is a well-known phenomenon that occurs at the cell membrane when cells are exposed to high-intensity electric pulses. Depending on electric pulse amplitude and number of puls… |
| Reversible | Shi et al · Molecules | 2018 | Derleme | Hayvan (İn Vivo) | – | Intracellular delivery is a critical step in biological discoveries and has been widely utilized in biomedical research. A variety of molecular tools have been developed for cell-based gene … |
| İrreversible | Meijerink et al · – | 2018 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Martijn R. Meijerink Hester J. Scheffer Govindarajan Narayanan Editors 123 Irreversible Electroporation in Clinical Practice Martijn R. Meijerink • Hester J. Scheffer Govindarajan Narayanan … |
| Reversible | Frandsen et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy is an anticancer treatment inducing uptake of chemotherapeutics by electroporation. This treatment is increasingly being used clinically and further investigations for im… |
| Reversible | Gehl et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | – | Electrochemotherapy has grown out of simple cell experiments through preclinical studies to experimental clinical studies, to an accepted treatment modality for cutaneous metastases for any … |
| Reversible | Kranjc et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Radiotherapy is the use of ionizing radiation in the treatment of malignant tumors. It is one of the main treatment modalities for many forms of cancer, with more than half of all cancer pat… |
| Reversible | Markelc et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Electroporation/electropermeabilization (EP), achieved by application of electric pulses to cells or tissues, induces reversible permeabilization of cell membranes under suitable conditions,… |
| Reversible | Serša et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Vasküler Kilit (Vascular Lock) Etkisi, Reversible Membran Permeabilizasyonu | Electroporation/electropermeabilization (EP), achieved by application of electric pulses to cells or tissues, induces reversible permeabilization of cell membranes under suitable conditions,… |
| Reversible | Serša et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Electrochemotherapy is the combination of chemotherapy and local application of electric pulses. Application of electric pulses, i.e., electroporation, is used as a means to increase drug de… |
| Reversible | De Robertis et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Gen Elektrotransferi (Plazmid DNA) | Emerging strategies in cancer treatments, such as gene electrotransfer and electrochemotherapy, are very promising. However, preclinical studies of effective therapeutic agents delivered in … |
| Reversible | Kamensek et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Sistemik / Abskopal İmmün Yanıt | Harnessing the body’s own immune system to fight cancer is one of the most encouraging fields of cancer research today. Promising new cancer immunotherapies are currently being tested in precl… |
| Reversible | Todorovic et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, İnterlökin-12 Aracılı İmmün Uyarım | Electrochemotherapy is a nonthermal tumor ablation modality. The local delivery of electric pulses directly to the tumor transiently increases permeabilization of the cell membrane and signi… |
| Reversible | Kos · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Electrochemotherapy and irreversible electroporation can be used to treat deepseated tumors. Key to treatment success is ensuring that the entirety of the target tumor is covered with electr… |
| İrreversible | Beebe · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Nanosaniye Darbeli Elektrik Alan (nsPEF) | Nanosecond pulses have been used for over a decade to treat tumors in preclinical studies in mice and rats. The technology based on pulsed power refocuses cancer treatment from chemistry and… |
| İrreversible | Beebe · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Apoptoz İndüksiyonu, Nanosaniye Darbeli Elektrik Alan (nsPEF) | This chapter will focus on how nanosecond pulsed electric fields (nsPEFs) induce apoptosis and regulated cell death (RCD) in cells in vitro. When studies analyzing nsPEF-induced cell death (C… |
| İrreversible | Bhonsle et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) employs a series of brief electric pulses to destabilize cell membranes by altering the transmembrane voltage to create nanoscale defects that induce cell … |
| İrreversible | Ho · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Electrolysis and electroporation technologies have been utilized to provide several valuable nonthermal tissue ablation modalities. The synergistic combination of electroporation and electro… |
| İrreversible | Martin · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Initially diagnosed stage 3 (locally advanced) pancreatic adenocarcinoma (LAPC) remains an aggressive tumor with an overall poor prognosis (current median survival chemotherapy and radiation… |
| İrreversible | Mucciardi et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) and cryoablation (Cryo) are, among the many others in use, respectively, the youngest and the oldest tissue ablation modalities. No other treatment has spr… |
| İrreversible | Nuccitelli · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | Apoptoz İndüksiyonu | Nanosecond electric pulses were first applied to mice for tumor ablation in 2002. Since that time this technology has been used in dozens of laboratories in the USA, Europe, and Asia (Batista… |
| İrreversible | Rolong et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The phenomenon of electroporation can be traced back to the eighteenth century when red spots on skin (Lichtenberg figures) were observed in the areas where electric fields were applied. Once … |
| İrreversible | Thomson et al · Handbook of Electroporation | 2017 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) for focal tumor control has developed since early human studies in 2009 to a point where it is now a useful part of the tumor eradication algorithm. While … |
| İrreversible | Vroomen et al · Diagn Interv Imaging | 2017 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Focal treatment with radiofrequency, microwave and cryoablation has been increasingly used for the treatment of tumors in patients who cannot undergo surgical resection and in select patient… |
| Reversible | Calvet et al · Cancer Metastasis Rev | 2016 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Anti-tumor electrochemotherapy, which consists in increasing anti-cancer drug uptake by means of electroporation, is now implanted in about 140 cancer treatment centers in Europe. Its use is… |
| Reversible | Rosazza · Curr Gene Ther | 2016 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | Gene electrotransfer is a powerful method of DNA delivery offering several medical applications, among the most promising of which are DNA vaccination and gene therapy for cancer treatment. … |
| İrreversible | Savic et al · Rofo | 2016 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Unlabelled: Irreversible electroporation (IRE) is the latest in the series of image-guided locoregional tumor ablation therapies. IRE is performed in a nearly non-thermal fashion that circum… |
| İrreversible | Wagstaff et al · Onco Targets Ther | 2016 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The field of focal ablative therapy for the treatment of cancer is characterized by abundance of thermal ablative techniques that provide a minimally invasive treatment option in selected tu… |
| Reversible | Lambricht et al · Expert Opin Drug Deliv | 2015 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | Introduction: Electroporation allows efficient delivery of DNA into cells and tissues, thereby improving the expression of therapeutic or immunogenic proteins that are encoded by plasmid DNA… |
| İrreversible | Jiang et al · IEEE Trans Biomed Eng | 2015 | Derleme | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The use of irreversible electroporation (IRE) for cancer treatment has increased sharply over the past decade. As a nonthermal therapy, IRE offers several potential benefits over other focal… |
| İrreversible | Narayanan · Semin Intervent Radiol | 2015 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a predominantly nonthermal ablative technology that uses high-voltage, low-energy DC current pulses to induce cell death. Thermal ablative technologies … |
| Reversible | Cadossi et al · Future Oncol | 2014 | Derleme | İnsan | Sistemik / Abskopal İmmün Yanıt | Electroporation is used to enhance drug diffusion and gene delivery into the cytosol. The combination of electroporation and cytotoxic drugs, electrochemotherapy (ECT), is used to treat meta… |
| Reversible | Miklavčič et al · Biomed Eng Online | 2014 | Derleme | İnsan | – | Electrochemotherapy is a local treatment of cancer employing electric pulses to improve transmembrane transfer of cytotoxic drugs. In this paper we discuss electrochemotherapy from the persp… |
| Reversible | O’Sullivan · Electroporation-Based Therapies for Cancer | 2014 | Derleme | Literatür Analizi | – | There are so many cancer patients for whom the current standard of cure doesn’t work. Electrochemotherapy could serve as an attractive alternative to many of these patients who have inoperab… |
| Reversible | Ramachandran et al · Electroporation-Based Therapies for Cancer | 2014 | Derleme | Literatür Analizi | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Cancer therapies mainly target the uncontrolled proliferation of the cancerous cells. A translational therapy for inoperable, chemo- and radio-resistant tumors is electroporationbased chemot… |
| Reversible | Yarmush et al · Annu Rev Biomed Eng | 2014 | Derleme | Hayvan (İn Vivo) | – | When high-amplitude, short-duration pulsed electric fields are applied to cells and tissues, the permeability of the cell membranes and tissue is increased. This increase in permeability is … |
| İrreversible | Deipolyi et al · Diagn Interv Radiol | 2014 | Derleme | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in … |
| İrreversible | Silk et al · Semin Intervent Radiol | 2014 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | A new ablation modality, irreversible electroporation (IRE), has been of increasing interest in interventional radiology. Its nonthermal mechanism of action of killing tumor cells allows phy… |
| İrreversible | Wagstaff et al · Curr Opin Urol | 2014 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose of review: This article provides an overview of recent developments in the field of thermal ablation for renal cell carcinoma and focuses on current standard techniques, new technolo… |
| Reversible | Geng et al · Lab Chip | 2013 | Derleme | Hayvan (İn Vivo) | – | Electroporation is a simple yet powerful technique for breaching the cell membrane barrier. The applications of electroporation can be generally divided into two categories: the release of i… |
| Reversible | Aurisicchio et al · Expert Rev Vaccines | 2013 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA) | Therapeutic vaccination could become an important modality to fight cancer. Efficacious immune responses against cancer cells have to be directed simultaneously against multiple epitopes bel… |
| Reversible | Chiarella et al · Curr Drug Metab | 2013 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Since conventional therapeutic approaches in cancer are highly invasive they hardly prolong patient survival for more than few months. Having the ability to stimulate both cellular and humou… |
| İrreversible | Golberg et al · IEEE Trans Biomed Eng | 2013 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Tissue ablation is an essential procedure for the treatment of many diseases. In the last decade, a nonthermal tissue ablation using intensive pulsed electric fields, called nonthermal irrev… |
| Reversible | Miklavčič et al · Med Biol Eng Comput | 2012 | Derleme | Hayvan (İn Vivo) | Ekstraselüler Matriks ve Doku İskeletinin Korunması, Elektrik Alan Dağılımı ve Modellemesi | Electrochemotherapy, a combination of high voltage electric pulses and of an anticancer drug, has been demonstrated to be highly effective in treatment of cutaneous and subcutaneous tumors. … |
| Reversible | Raeisi · – | 2012 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Biomedical imaging techniques play an important role in all phase of cancer management including detection, screening, biopsy guidance, staging, prognosis, therapy planning, therapy guidance… |
| Reversible | Testori et al · Curr Opin Oncol | 2012 | Derleme | İnsan | – | Purpose of review: In the present study, the role of electrochemotherapy (ECT) in the advanced melanoma setting, either as alternative treatment modality to conventional therapies or as pall… |
| Reversible | Gothelf et al · Hum Vaccin Immunother | 2012 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Vaccinations are increasingly used to fight infectious disease, and DNA vaccines offer considerable advantages, including broader possibilities for vaccination and lack of need for cold stor… |
| Reversible | Impellizeri et al · Vet Comp Oncol | 2012 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | The concept of vaccines based on the direct inoculation of plasmid DNA gained initial proof-of-concept in small rodent species. Further development was hampered by the difficulty to confirm … |
| Reversible | Breton et al · Bioelectromagnetics | 2011 | Derleme | İnsan | Nanosaniye Darbeli Elektrik Alan (nsPEF), İrreversible Por Oluşumu ve Hücre Ölümü | New local treatments based on electromagnetic fields have been developed as non-surgical and minimally invasive treatments of tumors. In particular, short electric pulses can induce importan… |
| Reversible | Murakami et al · Curr Gene Ther | 2011 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | Simple plasmid DNA injection is a safe and feasible gene transfer method, but it confers low transfection efficiency and transgene expression. This non-viral gene transfer method is enhanced… |
| Reversible | Cemazar et al · Curr Gene Ther | 2010 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | Electrogene therapy combines administration of plasmid DNA into tissue followed by local application of electric pulses. In electrogene therapy with interleukin-12 (IL-12), different routes … |
| İrreversible | Lee et al · Gut Liver | 2010 | Derleme | Literatür Analizi | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a novel tumor ablation technique using a non-thermal energy to create innumerable permanent nanopores in the cell membrane to disrupt cellular homeostas… |
| Reversible | Tang et al · Biochem Biophys Res Commun | 2009 | Derleme | Hücre Kültürü | Apoptoz İndüksiyonu | Electrical pulses have been widely used in biomedical fields, whose applications depend on the parameters such as durations and electric intensity. Conventional electroporation (0.1-1kV/cm, … |
| Reversible | Villemejane et al · Br J Pharmacol | 2009 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Physical methods of gene (and/or drug) transfer need to combine two effects to deliver the therapeutic material into cells. The physical methods must induce reversible alterations in the pla… |
| Reversible | Sadadcharam et al · Int J Hyperthermia | 2008 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | Purpose: The aim of this review article is to provide a concise overview of the pre-clinical development of electrochemotherapy (ECT), its present utility in clinical practice and to examine… |
| Reversible | Sersa et al · Eur J Surg Oncol | 2008 | Derleme | İnsan | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Reversible Membran Permeabilizasyonu | Aim: Electrochemotherapy is a local drug delivery approach aimed at treatment with palliative intent of cutaneous and subcutaneous tumour nodules of different histologies. Electrochemotherap… |
| Reversible | Sundararajan · Mol Biotechnol | 2008 | Derleme | İnsan | Gen Elektrotransferi (Plazmid DNA) | As the medical field moves from treatment of diseases with drugs to treatment with genes, safe and efficient gene delivery systems are needed to make this transition. One such safe, non-vira… |
| Reversible | Escoffre et al · Mol Biotechnol | 2008 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | Cell membranes can be transiently permeabilized under application of electric pulses. This treatment allows hydrophilic therapeutic molecules, such as anticancer drugs and DNA, to enter into… |
| Reversible | Cemazar et al · Curr Opin Mol Ther | 2007 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Electroporation is a physical method for the delivery of various molecules into cells by application of controlled external electrical fields that transiently increase permeability of the ce… |
| İrreversible | Rubinsky · Technol Cancer Res Treat | 2007 | Derleme | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | This is a brief introduction to the emerging field of irreversible electroporation in medicine. Certain electrical fields when applied across a cell can have as a sole effect the permeabiliz… |
| Reversible | Prud'homme et al · Curr Gene Ther | 2006 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Nonviral gene transfer is markedly enhanced by the application of in vivo electroporation (also denoted electro-gene transfer or electrokinetic enhancement). This approach is safe and can be… |
| Reversible | Chen et al · Med Biol Eng Comput | 2006 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | Electroporation, the transient increase in the permeability of cell membranes when exposed to a high electric field, is an established in vitro technique and is used to introduce DNA or othe… |
| Reversible | Yu et al · Dermatologic Surgery | 2005 | Derleme | İnsan | – | Background and objective As the number of patients with implantable cardiac devices escalates, inadvertent electromagnetic interference (EMI) by electrosurgery carries increasing concern for… |
| Reversible | Gothelf et al · Cancer Treat Rev | 2003 | Derleme | İnsan | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Over the last decade a new cancer treatment modality, electrochemotherapy, has emerged. By using short, intense electric pulses that surpass the capacitance of the cell membrane, permeabiliz… |
| Reversible | Mir · Bioelectrochemistry | 2001 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | Cell electropermeabilization (also termed cell electroporation) is nowadays a routine technique used in biochemical and pharmacological studies for the in vitro introduction of nonpermeant m… |
| Reversible | Somiari et al · Mol Ther | 2000 | Derleme | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | Efficient and safe methods for delivering exogenous genetic material into tissues must be developed before the clinical potential of gene therapy will be realized. Recently, in vivo electrop… |
| Reversible | Heller et al · Adv Drug Deliv Rev | 1999 | Derleme | Literatür Analizi | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy is a novel treatment which consists of a combination of a chemotherapeutic agent and pulsed electric fields. This relatively new treatment modality relies on the physical… |
| Reversible | Mir et al · Adv Drug Deliv Rev | 1999 | Derleme | Literatür Analizi | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy is a new therapeutic approach providing delivery into cell interiors of nonpermeant drugs with intracellular targets. It is based on the local application of short and in… |
| Reversible | Neumann et al · Bioelectrochem Bioenerg | 1999 | Derleme | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | Electrooptical and conductometrical relaxation methods have given a new insight in the molecular mechanisms of the electroporative delivery of drug-like dyes and genes (DNA) to cells and tis… |
| Reversible | Singh et al · Anticancer Drugs | 1999 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Gen Elektrotransferi (Plazmid DNA) | Tissue electroporation has been explored to enhance the local delivery of chemotherapueutic agents to solid tumors. The technique, known as electrochemotherapy (ECT), uses high-voltage pulse… |
| Reversible | Mir et al · Gen Pharmacol | 1996 | Derleme | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 1. Bleomycin (BLM) is a cytotoxic drug currently used in anticancer chemotherapy. We present here a summary of the well established "old" knowledge concerning BLM structure, properties and a… |
| Reversible | Dev et al · Cancer Treat Rev | 1994 | Derleme | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrik Alan Dağılımı ve Modellemesi | A critical review is presented on a novel method of treating cancer by a combination of an electric field with chemotherapeutic agents. The work described here summarizes the current state o… |
| Reversible | Laursen et al · J Vis Exp | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Bladder tumors constitute a substantial health challenge, yet advances in the treatment have been few. Electroporation is the use of brief electric pulses that permeabilize cell membranes wi… |
| Reversible | Molina-Pineda et al · Pharmaceutics | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Background/Objectives: Melanoma affects both sexes, and its incidence has increased in recent years. It is currently among the most common types of cancer. Standard chemotherapy, although ef… |
| Reversible | Tozon Mask et al · BMC Vet Res | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Electrochemotherapy (ECT) is a local ablative treatment and in veterinary oncology, evidence supporting ECT efficacy is mainly derived from case reports and small case series, underscoring t… |
| Reversible | Vargas et al · Res Vet Sci | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres | Introduction: The technique of electroporation is used to facilitate the selective delivery of chemotherapeutic drugs into neoplastic cells, a process known as electrochemotherapy. However, … |
| Reversible | Bendix et al · Bioelectrochemistry | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi | Dendritic cells (DCs) are central to the initiation of anti-tumour immunity, yet the direct effects of electrochemotherapy (ECT) on DC biology remain poorly defined. We investigated how vary… |
| Reversible | Bozic et al · Biomed Pharmacother | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | This study investigated the antitumor efficacy of chemokine CCL5 gene therapy using gene electrotransfer (GET) in combination with radiotherapy (RT) in solid murine tumors CT26 and 4T1. In v… |
| Reversible | Grimm et al · Sci Rep | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Gen Elektrotransferi (Plazmid DNA) | Coding nucleic acids (NAs) like DNA, mRNA or siRNA hold endless potential to engineer cells with respect to their genome and proteome. However, minimally invasive delivery of NAs across an i… |
| İrreversible | Cao et al · bioRxiv | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Sistemik / Abskopal İmmün Yanıt | Irreversible electroporation (IRE) has shown promise for treating pancreatic ductal adenocarcinoma (PDAC), but whether IRE can induce an abscopal effect is not established. We demonstrated t… |
| İrreversible | Liu · Commun Biol | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Although irreversible electroporation (IRE) is an approved ablation therapy for liver cancer, the border of the IRE-induced inflammatory margin (IM) remains poorly defined, posing a challeng… |
| İrreversible | Qi et al · Adv Mater | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres, İrreversible Por Oluşumu ve Hücre Ölümü | Cancer vaccines face limitations due to the immunosuppressive tumor microenvironment (TME) and the low immunogenicity of tumor antigens. Immunogenic cell death (ICD), triggered by mitochondr… |
| İrreversible | Sano et al · J Vasc Interv Radiol | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose: To study the safety and reproducibility of high-voltage integrated nanosecond pulse irreversible electroporation (INSPIRE) administered through a single applicator and grounding pad… |
| İrreversible | Vista et al · Clin Cancer Res | 2026 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Purpose: One recurring challenge in cell therapy for solid tumors is poor tumor infiltration of adoptively transferred T cells. We previously showed that a subablative dose of tumor-targeted… |
| Reversible | Bogataj et al · Cancers (Basel) | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Background: Electrochemotherapy (ECT) enhances the intracellular delivery of chemotherapeutic agents, most notably bleomycin, through electroporation. Despite high response rates, tumor sens… |
| Reversible | Malakauskaitė et al · Sci Rep | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | Electroporation can be successfully employed for controlled molecular delivery and therefore has found clinical applications for treatment of cancer. However, it’s a pulse-dependent phenomen… |
| Reversible | Radzevičiūtė-Valčiukė et al · Bioelectrochemistry | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy (ECT) is a cancer treatment approach that utilizes the application of electroporation (EP) with standard chemotherapeutic drugs, resulting in a locally enhanced chemother… |
| Reversible | de Caro et al · J Control Release | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Kas Kasılması ve Anestezi Gereksinimi, İmmünojenik Hücre Ölümü (ICD) | Electroporation, a physical method that permeabilizes cell membranes, is increasingly used in cancer treatment. By enhancing the uptake of hydrophilic antitumor drugs, it boosts their cytoto… |
| Reversible | Hu et al · Small | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Homeostazının Bozulması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | Calcium overload is a promising anticancer treatment that kills tumor cells primarily by causing mitochondrial dysfunction in cells. However, calcium overload therapy is limited by inefficie… |
| İrreversible | Aycock et al · IEEE Trans Biomed Eng | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a minimally thermal tissue ablation modality used to treat solid tumors adjacent to critical structures. Widespread clinical adoption of IRE has been li… |
| İrreversible | Esparza · Ann Biomed Eng | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | High-frequency irreversible electroporation (H-FIRE) is a minimally invasive local ablation therapy known to activate the adaptive immune system and reprogram the tumor microenvironment. Its… |
| İrreversible | Flak et al · Cancer Treat Res Commun | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Bleomisin Hücre İçi Birikiminin Artması | Background: Irreversible electroporation (IRE) is a novel anticancer ablative treatment, which has been proposed to enhance the efficacy of chemotherapy in the periphery of the ablated area … |
| İrreversible | Guo et al · IEEE Trans Biomed Eng | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | Objective: Irreversible electroporation (IRE) is a non-thermal tissue ablation technique that induces tissue ablation by applying high-voltage pulses through electrodes. In this paper, an im… |
| İrreversible | Hirata et al · Cardiovasc Intervent Radiol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Sistemik / Abskopal İmmün Yanıt | Purpose: This study aimed to compare systemic immune responses and metastatic effects induced by radiofrequency ablation (RFA) and irreversible electroporation (IRE) in murine tumor models. … |
| İrreversible | Korganbayev et al · Annu Int Conf IEEE Eng Med Biol Soc | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) represents a minimally invasive and non-thermal method for tumor ablation, which induces cell death through short high-voltage pulses applied via two needl… |
| İrreversible | Li et al · Small | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a minimally invasive, non-thermal tumor ablation technique that induces nanoscale membrane perforation, leading to immunogenic cell death (ICD). However… |
| İrreversible | Ma et al · World J Gastrointest Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Background: Irreversible electroporation (IRE) is a novel local tumor ablation approach with the potential to activate the host's immune system. However, this approach is insufficient to pre… |
| İrreversible | Murphy · Cells | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Kan-Beyin Bariyeri Geçirgenliğinin Artması, Reversible Membran Permeabilizasyonu | High-frequency irreversible electroporation (H-FIRE) is a nonthermal tumor ablation technique that disrupts the blood-brain barrier (BBB) in a focal and reversible manner. However, the mecha… |
| İrreversible | Nafie · Front Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Intoduction: Non-thermal ablation, including irreversible electroporation (IRE) and Aliya®, an advanced biphasic pulsed electric field (aPEF) technology, have emerged as effective tumor abla… |
| İrreversible | Wang et al · Gene | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Previous studies have demonstrated that synergistic bipolar irreversible electroporation (SBIRE) is a promising non-thermal tumor ablation technique that effectively targets tumors without c… |
| İrreversible | Williamson et al · Bioelectricity | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objective: To study the safety and reproducibility of high-voltage integrated nanosecond pulse irreversible electroporation (INSPIRE) administered through a single applicator and grounding p… |
| İrreversible | Xing et al · World J Gastrointest Oncol | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, İmmün Kontrol Noktası İnhibitörü Kombinasyonu | Background: Irreversible electroporation (IRE) represents an innovative localized technique for tumor ablation, possessing the capacity to activate the immune response of the host. However, … |
| İrreversible | Ye et al · J Cardiovasc Transl Res | 2025 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | This study evaluated the effects of irreversible electroporation (IRE), a non-thermal ablation method, on carotid atherosclerotic plaques induced by high-fat feeding combined with balloon di… |
| Reversible | Bryant et al · bioRxiv | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Unlabelled: This study presents the first in vivo and in vitro evidence of an externally controlled, predictive, MRI-based nanotheranostic agent capable of cancer cell specific targeting and… |
| Reversible | Fesmire et al · IEEE Trans Biomed Eng | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması, Sinir ve Damar Yapılarının Korunması | Objective: To study the safety and efficacy of algorithmically controlled electroporation (ACE) against spontaneous equine melanoma. Methods: A custom temperature sensing coaxial electrode w… |
| Reversible | Malyško-Ptašinskė et al · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | Electroporation-based procedures employing nanosecond bipolar pulses are commonly linked to an undesirable phenomenon known as the cancelation effect. The cancellation effect arises when the… |
| Reversible | Vilfan et al · Animals (Basel) | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Nekroz ve Nekroptoz, İnterlökin-12 Aracılı İmmün Uyarım | Electrochemotherapy (ECT) in combination with the gene electrotransfer of interleukin 12 (IL-12 GET) has been successfully used in veterinary medicine for the treatment of mast cell tumours … |
| Reversible | Ye et al · Stem Cell Res Ther | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Sisplatin Hücre İçi Birikiminin Artması | Background: Cisplatin (DDP) is an efficacious and widely applied chemotherapeutic drug for cervical cancer patients who are diagnosed as metastatic and inoperable, or desiring fertility pres… |
| Reversible | Lampreht · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Gene electrotransfer (GET) of plasmids encoding interleukin 12 (IL-12) has already been used for the treatment of various types of tumors in human oncology and as an adjuvant in DNA vaccines… |
| Reversible | Maji · Pharmaceutics | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Ekstraselüler Matriks ve Doku İskeletinin Korunması | Electroporation (EP) stands out as a promising non-viral plasmid delivery strategy, although achieving optimal transfection efficiency in vivo remains a challenge. A noteworthy advancement i… |
| İrreversible | Jeon · Cancers (Basel) | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, İrreversible Por Oluşumu ve Hücre Ölümü | The regulation of apoptosis is the primary goal of ablation therapy. Irreversible electroporation (IRE) is a promising non-thermal tissue ablation-based therapy that induces apoptosis by man… |
| İrreversible | Jeon et al · Int J Mol Sci | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a prominent non-thermal ablation method widely employed in clinical settings for the focal ablation therapy of solid tumors. Utilizing high-voltage, sho… |
| İrreversible | Rajagopalan et al · Bioelectrochemistry | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | Membrane permeabilization and thermal injury are the major cause of cell death during irreversible electroporation (IRE) performed using high electric field strength (EFS) and small number o… |
| İrreversible | Zeng et al · Sci Rep | 2024 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | To evaluate the safety and efficacy of combining EW-7197 with irreversible electroporation (IRE) for improving wound healing, 16 male Sprague-Dawley rats were randomly divided into four grou… |
| Reversible | Guedert et al · Bioelectrochemistry | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Termal Etki ve Joule Isınması | Electroporation alters cell membrane structure and tissue electrical properties by short and intense pulsed electric fields (PEF). Static mathematical models are often used to explain the ch… |
| Reversible | Kranjc Brezar et al · Bioelectrochemistry | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) is a local ablative therapy for the treatment of different skin and subcutaneous tumors and certain tumors in internal organs. Skeletal muscle represents a major tu… |
| Reversible | Olaiz et al · Cells | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Boron neutron capture therapy (BNCT) combines preferential tumor uptake of 10 B compounds and neutron irradiation. Electroporation induces an increase in the permeability of the cell membran… |
| Reversible | Radzevičiūtė-Valčiukė et al · Pharmaceuticals (Basel) | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | Calcium electroporation (CaEP) is an innovative approach to treating cancer, involving the internalization of supraphysiological amounts of calcium through electroporation, which leads to ce… |
| Reversible | Kamensek · Pharmaceutics | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | DNA vaccination is one of the emerging approaches for a wide range of applications, including prophylactic vaccination against infectious diseases and therapeutic vaccination against cancer.… |
| Reversible | Kesar et al · Vaccines (Basel) | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İmmünojenik Hücre Ölümü (ICD), Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) is a clinically acknowledged method that combines the use of anticancer drugs and electrical pulses. Electrochemotherapy with bleomycin (BLM) can induce immunogenic… |
| Reversible | Komel · Int J Mol Sci | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Gene immunotherapy has become an important approach in the treatment of cancer. One example is the introduction of genes encoding immunostimulatory cytokines, such as interleukin 2 and inter… |
| Reversible | Martins et al · Arch Virol | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has caused more than 760 million cases and over 6.8 million deaths a… |
| İrreversible | Jacobs et al · Comput Biol Med | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Termal Etki ve Joule Isınması, Darbe Parametrelerinin Optimizasyonu | The nonthermal mechanism for irreversible electroporation has been paramount for treating tumors and cardiac tissue in anatomically sensitive areas, where there is concern about damage to ne… |
| İrreversible | Jeon · Sci Rep | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Nonthermal irreversible electroporation (NTIRE) is emerging as a promising tissue ablation technique. However, maintaining irreversible electroporation (IRE) electrodes against displacement … |
| İrreversible | Peng et al · APL Bioeng | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Precise control of cargo release is essential but still a great challenge for any drug delivery system. Irreversible electroporation (IRE), utilizing short high-voltage pulsed electric field… |
| İrreversible | Razakamanantsoa et al · Bioelectrochemistry | 2023 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Irreversible electroporation (IRE) has been reported to variably cause apoptosis, necrosis, oncosis or pyroptosis. Intracellular ATP is a key substrate for apoptosis which is rapidly deplete… |
| Reversible | Bendix et al · Bioelectrochemistry | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | Electrochemotherapy (ECT) is becoming an established therapy for melanoma and is under investigation for application in additional cancer types. One potential cancer type that may benefit fr… |
| Reversible | Gudvangen et al · Sci Rep | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Kas Kasılması ve Anestezi Gereksinimi, Nanosaniye Darbeli Elektrik Alan (nsPEF) | Ablation therapies aim at eradication of tumors with minimal impact on surrounding healthy tissues. Conventional pulsed electric field (PEF) treatments cause pain and muscle contractions far… |
| Reversible | Novickij et al · IEEE Trans Biomed Eng | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | Objective: this work focuses on bleomycin electrochemotherapy using new modality of high repetition frequency unipolar nanosecond pulses. Methods: As a tumor model, Lewis lung carcinoma (LLC… |
| Reversible | Radzevičiūtė et al · Bioelectrochemistry | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Electroporation is a pulsed electric field (PEF) induced phenomenon, which effectiveness varies dependent on pulse parameters. This work focuses on nano-electrochemotherapy with bleomycin an… |
| Reversible | Balevičiūtė et al · Cancers (Basel) | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | In this work, a time-dependent and time-independent study on bleomycin-based high-frequency nsECT (3.5 kV/cm × 200 pulses) for the elimination of LLC1 tumours in C57BL/6J mice is performed. … |
| Reversible | Ruzgys · Cancers (Basel) | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | Sistemik / Abskopal İmmün Yanıt, Bleomisin Hücre İçi Birikiminin Artması | Electroporation-based antitumor therapies, including bleomycin electrotransfer, calcium electroporation, and irreversible electroporation, are very effective on directly treated tumors, but … |
| İrreversible | Kim · Sci Rep | 2022 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | As a non-thermal ablation method, irreversible electroporation (IRE) has been widely investigated in the treatment of prostate cancer. However, no consensus has been achieved on the optimal … |
| Reversible | Hendel et al · Drug Deliv | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional… |
| Reversible | Kim et al · Int J Mol Sci | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Kas Kasılması ve Anestezi Gereksinimi | Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects of PEF therapies are strong inv… |
| Reversible | Mansourian et al · Electromagn Biol Med | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | Electrochemotherapy (ECT) as a tumor treatment modality is approved for cutaneous and subcutaneous tumors. The purpose of the present study was to examine the effect of 900 MHz radiofrequenc… |
| Reversible | Navickaitė et al · Bioelectrochemistry | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Homeostazının Bozulması | The combination of Ca 2+ ions and electroporation has gained attention as potential alternative to electrochemotherapy. Ca 2+ is an important component of the cell membrane repair system and… |
| Reversible | Ruzgys · Molecules | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | One of current applications of electroporation is electrochemotherapy and electroablation for local cancer treatment. Both of these electroporation modalities share some similarities with ra… |
| Reversible | Valenti et al · Open Vet J | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Background: Electrochemotherapy (ECT) combines the administration of anticancer drugs with the delivery of electric pulses, thus increasing the drug uptake through the cell membranes, result… |
| Reversible | Kamensek et al · Bioelectrochemistry | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | In situ vaccination is a promising immunotherapeutic approach, where various local ablative therapies are used to induce an immune response against tumor antigens that are released from the … |
| Reversible | Kos · Pharmaceutics | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such a… |
| Reversible | Ursic et al · J Control Release | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy (ECT) exhibits high therapeutic effectiveness in the clinic, achieving up to 80% local tumor control but without a systemic (abscopal) effect. Therefore, we designed a co… |
| Reversible | Vižintin et al · Bioelectrochemistry | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Nanosecond electric pulses have several potential advantages in electroporation-based procedures over the conventional micro- and millisecond pulses including low level of heating, reduced e… |
| Reversible | Wu et al · Proc Natl Acad Sci U S A | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | Herein, we studied localized electroporation and gene transfection of mammalian cells using a metallodielectric hybrid micromotor that is magnetically and electrically powered. Much like nan… |
| İrreversible | Babikr et al · Cell Mol Immunol | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a new cancer ablation technology, but methods to improve IRE-induced therapeutic immunity are only beginning to be investigated. We developed a mouse mo… |
| İrreversible | Groen · Europace | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Aims Irreversible electroporation (IRE) ablation is a non-thermal ablation method based on the application of direct current between a multi-electrode catheter and skin electrode. The delive… |
| İrreversible | Li et al · Surg Endosc | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: The aim of this study was to evaluate the feasibility, safety, and efficacy of magnetic anchoring and guidance-assisted endoscopic irreversible electroporation (MAG-IRE) for gast… |
| İrreversible | Lim · Sci Rep | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The exposure of the prostate to high electric field strength during irreversible electroporation (IRE) has been extensively investigated. Multiple monopolar electrodes, however, have risks o… |
| İrreversible | Zhang et al · Int J Hyperthermia | 2021 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Kas Kasılması ve Anestezi Gereksinimi | Purpose: To examine the ablation zone, muscle contractions, and temperature increases in both rabbit liver and kidney models in vivo for a custom-made high-frequency irreversible electropora… |
| Reversible | Azan et al · Sci Rep | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | The permeabilization of the live cells membrane by the delivery of electric pulses has fundamental interest in medicine, in particular in tumors treatment by electrochemotherapy. Since under… |
| Reversible | Bo et al · Int J Mol Sci | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Reversible Membran Permeabilizasyonu | The principal bioeffect of the nanosecond pulsed electric field (nsPEF) is a lasting cell membrane permeabilization, which is often attributed to the formation of nanometer-sized pores. Such… |
| Reversible | García-Sánchez et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | This study presents electrical measurements (both conductivity during the pulses and impedance spectroscopy before and after) performed in liver tissue of mice during electroporation with cl… |
| Reversible | Kim et al · Technol Cancer Res Treat | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Reversible Membran Permeabilizasyonu | Tissue electrolysis is an alternative modality that uses a low intensity direct electric current passing through at least 2 electrodes within the tissue and resulting electrochemical product… |
| Reversible | Li et al · ACS Appl Mater Interfaces | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Mitokondriyal Disfonksiyon ve Oksidatif Stres | Cancer residues around the surgical site remain a significant cause of treatment failure with cancer recurrence. To prevent cancer recurrence and simultaneously repair surgery-caused defects… |
| Reversible | Mansourian et al · Electromagn Biol Med | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Electrochemotherapy (ECT) is a new and promising treatment strategy for cancer treatment. The aim of this work is to investigate the effect of 900 MHz radiofrequency electromagnetic fields (… |
| Reversible | Mansourian et al · Electromagn Biol Med | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Electrochemotherapy (ECT), the combination of electric pulses (EPs) and an anticancer drug, is a type of cancer treatment method. We investigated the effect of 217-Hz magnetic fields (MFs) s… |
| Reversible | Novickij · Sci Rep | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Doku İletkenliği ve Empedans Değişimi | In the present study, we report the effects of extracellular medium conductivity on cell response in the context of sub-microsecond range (100 ns-900 ns) electroporation, calcium electropora… |
| Reversible | Novickij et al · Molecules | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Doku İletkenliği ve Empedans Değişimi | Pulsed electric field (PEF) is frequently used for intertumoral drug delivery resulting in a well-known anticancer treatment-electrochemotherapy. However, electrochemotherapy is associated w… |
| Reversible | Qi et al · Natl Sci Rev | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi | By combined use of traditional Chinese acupuncture Fe needle electrode and in vivo electrochemistry, we achieved in vivo H 2 generation in tumors in a controllable manner and exploited it fo… |
| Reversible | Spugnini et al · Open Vet J | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Background: fFeline injection-site sarcomas (FISSs) are mesenchymal tumors that can occur in cats after injections of different medical agents and are easily prone to recurrence. Aim: The ai… |
| Reversible | Szewczyk et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | Calcium electroporation (CaEP) has been previously reported as an effective method of rhabdomyosarcoma cells reduction. CaEP causes temporary cell membrane permeabilization with simultaneous… |
| Reversible | Hawman et al · Nat Microbiol | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Hemostaz ve Kanama Kontrolü | There is currently no specific prophylaxis or vaccine against Crimean-Congo haemorrhagic fever virus (CCHFV). Crimean-Congo haemorrhagic fever (CCHF) is a severe febrile illness transmitted … |
| İrreversible | Merola et al · Biology (Basel) | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Objective: To test a new bipolar electrode for electroporation consisting of a single minimally invasive needle. Methods: A theoretical study was performed by using Comsol Multiphysics ® sof… |
| İrreversible | Polajžer et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | It was recently suggested that applying high-frequency short biphasic pulses (HF-IRE) reduces pain and muscle contractions in electrochemotherapy and irreversible ablation treatments; howeve… |
| İrreversible | Polajžer et al · Sci Rep | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Pulsed electric field treatment has increased over the last few decades with successful translation from in vitro studies into different medical treatments like electrochemotherapy, irrevers… |
| İrreversible | Vižintin et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | To achieve high efficiency of electroporation and to minimize unwanted side effects, the electric field parameters must be optimized. Recently, it was suggested that biphasic high-frequency … |
| İrreversible | Wasson et al · Bioelectrochemistry | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | High-frequency irreversible electroporation (H-FIRE) is an emerging electroporation-based therapy used to ablate cancerous tissue. Treatment consists of delivering short, bipolar pulses (1-1… |
| İrreversible | Wood et al · J Surg Res | 2020 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | Background: Nonthermal irreversible electroporation (NTIRE) has been shown to ablate the small intestinal epithelium while maintaining submucosal and muscularis propriae integrity. NTIRE is … |
| Reversible | Bagalkot et al · Sci Rep | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Nanosaniye Darbeli Elektrik Alan (nsPEF) | Exposing adrenal chromaffin cells to single 150 to 400 ns electric pulses triggers a rise in intracellular Ca 2+ ([Ca 2+ ] i ) that is due to Ca 2+ influx through voltage-gated Ca 2+ channel… |
| Reversible | Casciola et al · Cell Mol Life Sci | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | The initiation of action potentials (APs) by membrane depolarization occurs after a brief vulnerability period, during which excitation can be abolished by the reversal of the stimulus polar… |
| Reversible | Garabalino et al · Radiat Environ Biophys | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Boron neutron capture therapy (BNCT) is a promising cancer binary therapy modality that utilizes the nuclear capture reaction of thermal neutrons by boron-10 resulting in a localized release… |
| Reversible | García-Sánchez et al · Bioelectrochemistry | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Doku İletkenliği ve Empedans Değişimi | In this study the evolution in the efficiency of electrochemotherapy (reversible electroporation) with pulse number was assessed in vitro. Experiments were performed using 100 μs pulses at d… |
| Reversible | Lorenzo et al · Cancers (Basel) | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Kan-Beyin Bariyeri Geçirgenliğinin Artması, Elektrik Alan Dağılımı ve Modellemesi | Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due to protection from the blood-brain barrier (BBB). Electroporation-based thera… |
| Reversible | Pedersoli et al · Eur Radiol | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objectives: We conducted an in vivo trial to investigate the safety and efficacy of a newly developed system for the application of a combined therapy consisting of irreversible electroporat… |
| Reversible | Pintarelli et al · Med Eng Phys | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) exploits the phenomenon of electroporation, which is the increase of cell permeability through the application of an electrical field. This technique is applied in … |
| Reversible | Donnelly et al · J Aquat Anim Health | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Kas Kasılması ve Anestezi Gereksinimi | Fibropapillomatosis of sea turtles is traditionally treated with surgical debulking techniques that are often associated with prolonged healing and tumor recurrence. Electrochemotherapy was … |
| Reversible | Ruzgys et al · Bioelectrochemistry | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Darbe Parametrelerinin Optimizasyonu | Electroporation is a widely-used methodology for permeabilization of cells using pulsed electric field (PEF). In this paper, we compare the electroporation efficiency in terms of molecular t… |
| İrreversible | Novickij · Cancers (Basel) | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | In this work, we have investigated the feasibility of sub-microsecond range irreversible electroporation (IRE) with and without calcium electroporation in vivo. As a model, BALB/C mice were … |
| İrreversible | Ringel-Scaia et al · EBioMedicine | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible electroporation (H-FIRE… |
| İrreversible | Tian · Molecules | 2019 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) kills tumor cells by the delivery of short pulses of strong electric fields. However, the field strength decreases with distance from the treatment center.… |
| Reversible | Berkenbrock et al · J Healthc Eng | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | Electrochemotherapy is an anticancer treatment based on applying electric field pulses that reduce cell membrane selectivity, allowing chemotherapy drugs to enter the cells. In parallel to e… |
| Reversible | Bhonsle et al · IEEE Trans Biomed Eng | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrot Geometrisi ve Yerleşimi | Objective: The use of high-voltage, high-frequency bipolar pulses (HFBPs) is an emerging electroporation-based therapy for the treatment of solid tumors. In this study, we quantify the exten… |
| Reversible | Dermol-Černe et al · J Control Release | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | In electrochemotherapy two conditions have to be met to be successful - the electric field of sufficient amplitude and sufficient uptake of chemotherapeutics in the tumor. Current treatment … |
| Reversible | Huang et al · Theranostics | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Rationale: Delivery of nucleic acid molecules into skin remains a main obstacle for various types of gene therapy or vaccine applications. Here we propose a novel electroporation approach vi… |
| Reversible | Markelc et al · J Control Release | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Vasküler Kilit (Vascular Lock) Etkisi | Delivery of electric field pulses, i.e. electroporation (EP), to tissues has been shown to have a blood flow modifying effect. Indeed, the diameter of blood vessels exposed to EP is immediat… |
| Reversible | Semenov et al · Bioelectrochemistry | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | Decreasing the time gap between two identical electric pulses is expected to render bioeffects similar to those of a single pulse of equivalent total duration. In this study, we show that it… |
| Reversible | Srimathveeravalli et al · Mol Imaging | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal… |
| Reversible | Staresinic et al · Sci Rep | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | Calcium electroporation (CaEP) is a novel anti-tumour treatment that induces cell death by internalization of large quantities of calcium. The anti-tumour effectiveness of CaEP has been demo… |
| Reversible | Cemazar et al · Bioelectrochemistry | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Electric field-induced membrane changes are an important approach in the life sciences. However, the developments in knowledge and translational applications face problems of reproducibility… |
| Reversible | Burkart et al · Gene Ther | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | The use of immunomodulatory cytokines has been shown effective in regressing a wide range of tumors. However, systemic delivery of recombinant cytokines results in serious, potentially life-… |
| Reversible | Cervia et al · Mol Pharm | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Electrotransfection (ET) is a nonviral method for delivery of various types of molecules into cells both in vitro and in vivo. Close to 90 clinical trials that involve the use of ET have bee… |
| Reversible | Duong et al · Biomaterials | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Despite the tremendous potential of DNA-based cancer vaccines, their efficacious delivery to antigen presenting cells to stimulate both humoral and cellular response remains a major challeng… |
| Reversible | Mukhopadhyay et al · Gene Ther | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Sistemik / Abskopal İmmün Yanıt | Intratumoral electroporation-mediated IL-12 gene therapy (IT-pIL12/EP) has been shown to be safe and effective in clinical trials, demonstrating systemic antitumor effects with local deliver… |
| Reversible | Tremble et al · Cancer Lett | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İmmünojenik Hücre Ölümü (ICD) | Electrochemotherapy is an evolving therapy which has recently been shown to induce an immunogenic form of cell death. It is hypothesized that the immunogenic cell death induced by electroche… |
| İrreversible | Latouche et al · Technol Cancer Res Treat | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | High-frequency irreversible electroporation is a nonthermal method of tissue ablation that uses bursts of 0.5- to 2.0-microsecond bipolar electric pulses to permeabilize cell membranes and i… |
| İrreversible | Mi et al · Technol Cancer Res Treat | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | We studied the influence of various parameters of high-frequency nanosecond pulse bursts on the strength of rabbit muscle contractions. Ten unipolar high-frequency pulse bursts with various … |
| İrreversible | O’Brien et al · Int J Hyperthermia | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and tempera… |
| İrreversible | Sano et al · J Vasc Interv Radiol | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Kas Kasılması ve Anestezi Gereksinimi | Purpose: To compare the intensity of muscle contractions in irreversible electroporation (IRE) treatments when traditional IRE and high-frequency IRE (H-FIRE) waveforms are used in combinati… |
| İrreversible | Tian et al · Drug Deliv | 2018 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is an emerging minimally invasive tumor ablation technique that delivers short pulses of strong electric fields and kills cancer cells by disrupting their … |
| Reversible | Caprettini et al · Sci Rep | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electroporation of in-vitro cultured cells is widely used in biological and medical areas to deliver molecules of interest inside cells. Since very high electric fields are required to elect… |
| Reversible | Ciobanu et al · J Membr Biol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | Electric pulses, when applied to a cell suspension, induce a reversible permeabilization of the plasma membrane. This permeabilized state is a long-lived process (minutes). The biophysical m… |
| Reversible | Hanna et al · Sci Rep | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Nanosaniye Darbeli Elektrik Alan (nsPEF) | Microsecond pulsed electric fields (μsPEF) permeabilize the plasma membrane (PM) and are widely used in research, medicine and biotechnology. For internal membranes permeabilization, nanosec… |
| Reversible | Rezaee et al · Int J Nanomedicine | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Background and objective: Radiation therapy (RT) is the gold standard treatment for more than half of known tumors. Despite recent improvements in RT efficiency, the side effects of ionizing… |
| Reversible | Zhang et al · Am J Physiol Lung Cell Mol Physiol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Exosomes are nanovesicles secreted by cells and contain various molecules including protein, lipid, and DNA/RNA. They are crucial mediators of the intercellular communication and serve as pr… |
| Reversible | Frandsen et al · Cancer Res | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Nekroz ve Nekroptoz | Calcium electroporation may offer a simple general tool for anticancer therapy. Transient permeabilization of cancer cell membranes created by applying short, high-voltage pulses in tumors e… |
| Reversible | Kamensek et al · Plasmid | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Electrotransfer mediated delivery of interleukin-12 (IL-12) gene, encoded on a plasmid vector, has already been demonstrated to have a potent antitumor efficacy and great potential for clini… |
| Reversible | Kos et al · Bioelectrochemistry | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | Skin is an attractive target for gene electrotransfer due to its easy accessibility and its interesting immune properties. Since electrodes are often invasive and frequently induce discomfor… |
| Reversible | Sales et al · Vaccine | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | In vivo electroporation (EP) has reignited the clinical interest on DNA vaccines as immunotherapeutic approaches to control different types of cancer. EP has been associated with increased i… |
| Reversible | Salvadori et al · Radiol Oncol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | Background: The study was aimed to characterize tumor response after combined treatment employing electrochemotherapy with IL-12 gene electrotransfer in dogs with spontaneous mast cell tumor… |
| İrreversible | Chai et al · Biomed Microdevices | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The aim of this study was to evaluate the effects of irreversible electroporation (IRE) on the eradication of rabbit VX2 cervical tumors. A VX2 cervical cancer model was first made in 20 New… |
| İrreversible | Kranjc · Sci Rep | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is gaining importance in routine clinical practice for nonthermal ablation of solid tumors. For its success, it is extremely important that the coverage an… |
| İrreversible | Rajeckaitė et al · J Membr Biol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | The aim of this study was to investigate the dependence of calcein extraction and cell viability on the parameters of pulsed electric field (PEF). Two different approaches concerning PEF par… |
| İrreversible | Srimathveeravalli et al · J Vasc Interv Radiol | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: To evaluate the effect of catheter-directed irreversible electroporation (IRE) on the integrity, patency, and function of the normal porcine ureter. Materials and methods: A cathete… |
| İrreversible | Yao · Sci Rep | 2017 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) uses ~100 μs pulsed electric fields to disrupt cell membranes for solid tumor ablation. Although IRE has achieved exciting preliminary clinical results, im… |
| Reversible | Dermol et al · PLoS One | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Electroporation-induced cell sensitization was described as the occurrence of a delayed hypersensitivity to electric pulses caused by pretreating cells with electric pulses. It was achieved … |
| Reversible | Dovgan et al · J Membr Biol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | New cryopreservation approaches for medically applicable cells are of great importance in clinical medicine. Current protocols employ the use of dimethyl sulfoxide (DMSO), which is toxic to … |
| Reversible | Maglietti et al · Radiol Oncol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Background: Electrochemotherapy (ECT), a medical treatment widely used in human patients for tumor treatment, increases bleomycin toxicity by 1000 fold in the treated area with an objective … |
| Reversible | Phillips et al · Ann Biomed Eng | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | A synergistic combination of electroporation and electrolysis (SEE) has been found with distinct advantages over tissue ablation by electrolysis or electroporation alone. Minimally invasive … |
| Reversible | Silve et al · Sci Rep | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | The impact of external medium conductivity on the efficiency of the reversible permeabilisation caused by pulsed electric fields was investigated. Pulses of 12 ns, 102 ns or 100 μs were inve… |
| Reversible | Sweeney et al · Biochim Biophys Acta | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | High-frequency bipolar electric pulses have been shown to mitigate undesirable muscle contraction during irreversible electroporation (IRE) therapy. Here, we evaluate the potential applicabi… |
| Reversible | Zielichowska et al · Bioelectrochemistry | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | The electroporation (EP) supports various types of anticancer therapies by the selective transport of cytostatics. Increase in intracellular calcium level by EP may be a new approach to fibr… |
| Reversible | Cicchelero et al · Vet Comp Oncol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Interleukin 12 (IL-12) is a powerful immunostimulatory cytokine with a strong antitumoural activity. In this work, the immunological, anti-angiogenic and clinical effects of three consecutiv… |
| Reversible | Stimac et al · Cancer Gene Ther | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Apoptoz İndüksiyonu | Gene electrotransfer of plasmid encoding shRNA against endoglin exerts antitumor efficacy, predominantly by vascular targeted effect. As vascular targeting therapies can promote radiosensiti… |
| İrreversible | Bonakdar et al · Biophys J | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | Kan-Beyin Bariyeri Geçirgenliğinin Artması, Reversible Membran Permeabilizasyonu | The blood-brain barrier, mainly composed of brain microvascular endothelial cells, poses an obstacle to drug delivery to the brain. Controlled permeabilization of the constituent brain endot… |
| İrreversible | Wandel et al · J Vasc Interv Radiol | 2016 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: To optimize single-insertion bipolar irreversible electroporation (IRE) by characterizing effects of electric parameters and controlling tissue electric properties in a porcine mode… |
| Reversible | Demiryurek et al · Biochim Biophys Acta | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Electroporation is of interest for many drug-delivery and gene-therapy applications. Prior studies have shown that a two-pulse-electroporation protocol consisting of a short-duration, high-v… |
| Reversible | Dolinsek et al · Curr Gene Ther | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | New targets and therapeutic approaches for vascular targeted strategies in oncology are continuously explored. Endoglin, a co-receptor of TGF-β, is a known target, however, its silencing wit… |
| Reversible | Gianulis et al · Arch Biochem Biophys | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Lanthanide ions are the only known blockers of permeabilization by electric pulses of nanosecond duration (nsEP), but the underlying mechanisms are unknown. We employed timed applications of… |
| Reversible | Mahmood et al · Acta Oncol | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | Background: Tissue permeabilization by electroporation (EP) is a promising technique to treat certain cancers. Non-invasive methods for verification of induced permeabilization are important… |
| Reversible | Semenov et al · Biochim Biophys Acta | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | Ca2+ activation and membrane electroporation by 10-ns and 4-ms electric pulses (nsEP and msEP) were compared in rat embryonic cardiomyocytes. The lowest electric field which triggered Ca2+ t… |
| Reversible | Trainito et al · Electrophoresis | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | The electric field is commonly used in microdevices to handle, treat, or monitor living cells for various biological or biomedical applications (cells electrofusion, gene electrotransfer, dr… |
| Reversible | Vernier et al · J Membr Biol | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | Non-thermal probing and stimulation with subnanosecond electric pulses and terahertz electromagnetic radiation may lead to new, minimally invasive diagnostic and therapeutic procedures and t… |
| Reversible | Bosnjak et al · Gene Ther | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Gene therapy with Plasmid AMEP (antiangiogenic metargidin peptide) has recently been studied as a potential targeted therapy for melanoma. This plasmid is designed to downregulate α5β1 and α… |
| Reversible | Heller et al · Adv Genet | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Plasmid or non-viral gene therapy offers an alternative to classic viral gene delivery that negates the need for a biological vector. In this case, delivery is enhanced by a variety of appro… |
| Reversible | Lamolinara et al · J Immunol Res | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Skin represents an attractive target for DNA vaccine delivery because of its natural richness in APCs, whose targeting may potentiate the effect of vaccination. Nevertheless, intramuscular e… |
| Reversible | Markelc et al · Bioelectrochemistry | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | Application of electric pulses (electroporation/electropermeabilization) is an effective method for gene transfer (i.e. gene electrotransfer (GET)) in vitro and in vivo. Currently, the mecha… |
| Reversible | Pavlin et al · Sci Rep | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | Gene electrotransfer is a promising non-viral method of gene delivery. In our in vitro study we addressed open questions about this multistep process: how electropermeabilization is related … |
| Reversible | Thalmensi et al · Oncoimmunology | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Human telomerase reverse transcriptase (hTERT) is overexpressed in more than 85% of human cancers regardless of their cellular origin. As immunological tolerance to hTERT can be overcome not… |
| Reversible | Kranjc et al · Radiology | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | Purpose: To investigate the feasibility of magnetic resonance (MR) electric impedance tomography ( EIT electric impedance tomography ) technique for in situ monitoring of electric field dist… |
| Reversible | Marčan et al · Biomed Eng Online | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi | Background: Treatments based on electroporation are a new and promising approach to treating tumors, especially non-resectable ones. The success of the treatment is, however, heavily depende… |
| İrreversible | Golberg et al · Sci Rep | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | Irreversible electroporation (IRE) is an emerging, minimally invasive technique for solid tumors ablation, under clinical investigation for cancer therapy. IRE affects only the cell membrane… |
| İrreversible | Serša · Biomed Eng Online | 2015 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | Background: Electroporation is gaining its importance in everyday clinical practice of cancer treatment. For its success it is extremely important that coverage of the target tissue, i.e. tr… |
| Reversible | Frandsen et al · Biochim Biophys Acta | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Bleomisin Hücre İçi Birikiminin Artması | Background: Electroporation with calcium (calcium electroporation) can induce ATP depletion-associated cellular death. In the clinical setting, the cytotoxic drug bleomycin is currently used… |
| Reversible | Hudej et al · J Membr Biol | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | To increase electrochemotherapy (ECT) applicability, the effectiveness of new drugs is being tested in combination with electroporation. Among them two ruthenium(III) compounds, (imH)[trans-… |
| Reversible | Prosen · Mol Ther Nucleic Acids | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | The melanoma cell adhesion molecule (MCAM) is involved in melanoma development and its progression, including invasiveness, metastatic potential and angiogenesis. Therefore, MCAM represents … |
| Reversible | Rangel et al · J Membr Biol | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Connexins are proteins that form gap junctions. Perturbations in the cell membrane reportedly promote changes in the expression profile of connexins. Electroporation promotes destabilization… |
| Reversible | Spugnini et al · J Cell Physiol | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | Electrochemotherapy (ECT) is a cancer therapy that conjugates the administration of a chemotherapy agent to the delivery of permeabilizing pulses released singularly or as bursts. This appro… |
| Reversible | Calvet · Mol Ther Methods Clin Dev | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | DNA vaccination consists in administering an antigen-encoding plasmid in order to trigger a specific immune response. This specific vaccine strategy is of particular interest to fight agains… |
| Reversible | Calvet et al · Oncoimmunology | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | DNA vaccination consists of administering an antigen-coding nucleotide sequence. In order to improve the efficacy of DNA vaccines, electroporation is one of the most commonly used methods to… |
| Reversible | Grunwald et al · J Virol | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Sistemik / Abskopal İmmün Yanıt, Gen Elektrotransferi (Plazmid DNA) | Unlabelled: Induction of long-lasting immunity against viral respiratory tract infections remains an elusive goal. Using a nonhuman primate model of human respiratory syncytial virus (hRSV) … |
| Reversible | Todorovic et al · Bioelectrochemistry | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | Gene electrotransfer is an established method for plasmid delivery into different tissues. Contrary to extensive in vitro studies demonstrating increased gene electrotransfer by changing the… |
| İrreversible | Grys · Cell Mol Biol Lett | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | The recently described method of cell electroporation by flow of cell suspension through localized direct current electric fields (dcEFs) was applied to identify non-toxic substances that co… |
| İrreversible | Sano et al · Bioelectrochemistry | 2014 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Under the influence of external electric fields, cells experience a rapid potential buildup across the cell membrane. Above a critical threshold of electric field strength, permanent cell da… |
| Reversible | Markelc et al · PLoS One | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Vasküler Kilit (Vascular Lock) Etkisi, Antivasküler Etki ve Damar Yıkımı | Electropermeabilization/electroporation (EP) provides a tool for the introduction of molecules into cells and tissues. In electrochemotherapy (ECT), cytotoxic drugs are introduced into cells… |
| Reversible | Neal et al · Ann Biomed Eng | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) achieves targeted volume non-thermal focal ablation using a series of brief electric pulses to kill cells by disrupting membrane integrity. Electrochemothe… |
| Reversible | Pakhomova et al · J Cell Mol Med | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Cell permeabilization by electric pulses (EP), or electroporation, is widely used for intracellular delivery of drugs and plasmids, as well as for tumour and tissue ablation. We found that c… |
| Reversible | Semenov et al · Biochim Biophys Acta | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Kalsiyum Homeostazının Bozulması | Permeabilization of cell membranous structures by nanosecond pulsed electric field (nsPEF) triggers transient rise of cytosolic Ca(2+) concentration ([Ca(2+)](i)), which determines multifari… |
| Reversible | Wu et al · Sci Rep | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | – | We present a multi-functional electroporation method for delivery of biomolecule utilizing a high-density distributed electrode network (HDEN) under tri-phase electric stimulation. The HDEN … |
| Reversible | Yun et al · Lab Chip | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi | We developed an on-chip microscale electroporation system that enables sequential delivery of multiple molecules with precise and independent dosage controllability into pre-selected identic… |
| Reversible | Kamensek · Mol Cancer | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Background: Radiation induced transcriptional targeting is a gene therapy approach that takes advantage of the targeting abilities of radiotherapy by using radio inducible promoters to spati… |
| Reversible | Liew et al · Hum Gene Ther Methods | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Mesenchymal stem cells (MSCs) are multipotent nonhematopoietic cells with the ability to differentiate into various specific cell types, thus holding great promise for regenerative medicine.… |
| Reversible | Rosazza et al · Mol Ther | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Electroporation is a physical method of transferring molecules into cells and tissues. It takes advantage of the transient permeabilization of the cell membrane induced by electric field pul… |
| Reversible | Tesic et al · J Membr Biol | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Development of recombinant DNA technologies has allowed us to create new delivery systems that target specific cell types and that can be used in gene therapy. One of these targets is vascul… |
| İrreversible | Ben-David et al · Radiology | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: To study the effects of the surrounding electrical microenvironment and local tissue parameters on the electrical parameters and outcome of irreversible electroporation (IRE) ablati… |
| İrreversible | Faroja et al · Radiology | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: To determine whether high-dose irreversible electroporation (IRE) ablation induces thermal effects in normal liver tissue. Materials and methods: Animal care and use committee appro… |
| İrreversible | Kim et al · Biochem Biophys Res Commun | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Apoptoz İndüksiyonu | Irreversible electroporation is a novel method of ablating living tissues through its non-thermal effects, unlike radiofrequency ablation which has a severe problem of heat sink. It is due t… |
| İrreversible | Korohoda · Cell Mol Biol Lett | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Experiments on reversible and irreversible cell electroporation were carried out with an experimental setup based on a standard apparatus for horizontal electrophoresis, a syringe pump with … |
| İrreversible | Maglietti et al · PLoS One | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Darbe Parametrelerinin Optimizasyonu | Treatments based on electroporation (EP) induce the formation of pores in cell membranes due to the application of pulsed electric fields. We present experimental evidence of the existence o… |
| İrreversible | Neal et al · PLoS One | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a non-thermal focal ablation technique that uses a series of brief but intense electric pulses delivered into a targeted region of tissue, killing the c… |
| İrreversible | Sommer et al · J Vasc Interv Radiol | 2013 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: To analyze irreversible electroporation (IRE) of the pig kidney with involvement of the renal pelvis. Materials and methods: IRE of renal tissue including the pelvis was performed i… |
| Reversible | Bellard et al · J Control Release | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Vasküler Kilit (Vascular Lock) Etkisi | Electroporation/electropermeabilization, i.e. the result of the application of electric pulses to tissues, is a physical method for delivery of exogenous molecules into cells. It is effectiv… |
| Reversible | Calmels et al · Technol Cancer Res Treat | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Bleomisin Hücre İçi Birikiminin Artması | In vivo cell electropermeabilization can be used alone or in combination with a hydrophilic, nonpermeant cytotoxic drug such as bleomycin (electrochemotherapy) to efficiently treat tumors. W… |
| Reversible | Frandsen et al · Cancer Res | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Nekroz ve Nekroptoz | Electroporation of cells with short, high-voltage pulses causes a transient permeabilization of cell membranes that permits passage of otherwise nonpermeating ions and molecules. In this stu… |
| Reversible | Kaminska et al · Gen Physiol Biophys | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Reversible Membran Permeabilizasyonu | Application of a high electric field causes an electric shock to the heart. This is utilized in defibrillation to reestablish normal contraction rhythms during dangerous arrhythmias or in ca… |
| Reversible | Markelc et al · J Membr Biol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | Electropermeabilization/electroporation (EP) is a physical method that by application of electric pulses to cells increases cell membrane permeability and enables the introduction of molecul… |
| Reversible | Meschini et al · Eur J Cancer | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Few articles in the literature have focused on electroporation as a strategy to reverse multidrug resistance (MDR) of tumour cells and they are mostly limited to the improved efficacy of ble… |
| Reversible | Mozdarani et al · Cell J | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Objective: In electrochemotherapy (ECT), there is an unpleasant sensation of muscle contraction when using a low frequency (1 Hz). Therefore, by increasing the pulse frequency above the teta… |
| Reversible | Pakhomova et al · Arch Biochem Biophys | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Mitokondriyal Disfonksiyon ve Oksidatif Stres | Nanosecond pulsed electric field (nsPEF) is a novel modality for permeabilization of membranous structures and intracellular delivery of xenobiotics. We hypothesized that oxidative effects o… |
| Reversible | Pelofy et al · J Membr Biol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu | Despite great potential for disease treatment, small interfering RNA (siRNA) development has been hampered due to its poor stability and the lack of efficient delivery method. To overcome th… |
| Reversible | Silve et al · Bioelectrochemistry | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | In our study, we used bleomycin to evaluate the permeabilization caused by nanosecond duration electric pulses (nanopulses). Bleomycin is a non permeant molecule which can be used both as a … |
| Reversible | Van Lint et al · Cancer Res | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | – | The use of tumor-associated antigen (TAA) mRNA for therapeutic purposes is under active investigation. To be effective, mRNA vaccines need to deliver activation stimuli in addition to TAAs t… |
| Reversible | Arigoni et al · Angiogenesis | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Nekroz ve Nekroptoz | Angiomotin (Amot) is one of several identified angiostatin receptors expressed by the endothelia of angiogenic tissues. We have shown that a DNA vaccine targeting Amot overcome immune tolera… |
| Reversible | Cemazar et al · Hum Gene Ther | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Ekstraselüler Matriks ve Doku İskeletinin Korunması | One of the applications of electroporation/electropulsation in biomedicine is gene electrotransfer, the wider use of which is hindered by low transfection efficiency in vivo compared with vi… |
| Reversible | Chopinet et al · Int J Pharm | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | Electro-gene-therapy is a promising technique for cancer treatment. However, knowledge about mechanism of gene transfer with electric field in tumor is limited. Whereas in vitro electrotrans… |
| Reversible | Kardos et al · Hum Vaccin Immunother | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Electroporation, an attractive process for delivering DNA and other molecules into target cells in vivo and in vitro is limited by the necessity of electrodes that need to be in contact with… |
| Reversible | Rosazza et al · Int J Pharm | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | The delivery of therapeutic molecules such as plasmid DNA in cells and tissues by means of electric fields holds great promise for anticancer treatment. To allow for their therapeutic action… |
| Reversible | Sin et al · Cancer Immunol Immunother | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım | Intratumoral electroporation (IT-EP) with IL-12 cDNA (IT-EP/IL12) can lead to the eradication of established B16 melanoma tumors in mice. Here, we explore the immunological mechanism of the … |
| İrreversible | Arena et al · Biophys J | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | Irreversible electroporation (IRE) is emerging as a powerful tool for tumor ablation that utilizes pulsed electric fields to destabilize the plasma membrane of cancer cells past the point of… |
| İrreversible | Garcia et al · PLoS One | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Kan-Beyin Bariyeri Geçirgenliğinin Artması | The blood-brain-barrier (BBB) presents a significant obstacle to the delivery of systemically administered chemotherapeutics for the treatment of brain cancer. Irreversible electroporation (… |
| İrreversible | LIU et al · Oncol Lett | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a new tumor ablation technique. Pulsed electric fields (PEFs) with permanent duration (100 μsec) permanently permeabilize the cell membrane, causing the… |
| İrreversible | Phillips et al · Br J Cancer | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: Non-thermal irreversible electroporation (NTIRE) has recently been conceived as a new minimally invasive ablation method, using microsecond electric fields to produce nanoscale d… |
| İrreversible | Schoellnast et al · Eur Radiol | 2012 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Objective: To evaluate the delayed effects of irreversible electroporation (IRE) ablation on nerves. Methods: The study was approved by the institutional animal care and use committee. CT-gu… |
| Reversible | Diao · World J Gastroenterol | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Nekroz ve Nekroptoz, Mitokondriyal Disfonksiyon ve Oksidatif Stres | Aim: To investigate the effect of transgenic expression of kallistatin (Kal) on carbon tetrachloride (CCl(4))-induced liver injury by intramuscular (im) electrotransfer of a Kal-encoding pla… |
| Reversible | Shankayi et al · J Membr Biol | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Bleomisin Hücre İçi Birikiminin Artması | The most important unpleasant sensation of electrochemotherapy is muscle contraction. One of the causes of this discomfort is electrochemotherapy in the low-frequency range (1 Hz). To resolv… |
| Reversible | Spugnini et al · J Transl Med | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Sisplatin Hücre İçi Birikiminin Artması | Background: Nucleic acids designed to modulate the expression of target proteins remain a promising therapeutic strategy in several diseases, including cancer. However, clinical success is l… |
| Reversible | Vittorio et al · Nanotechnology | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | – | In this study we investigate the potential of multiwall carbon nanotubes (MWCNTs) with low metal impurities (2.57% iron) as magnetic resonance imaging (MRI) contrast agents. Taking into acco… |
| Reversible | Donate et al · PLoS One | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi | Current progress in the development of vaccines has decreased the incidence of fatal and non-fatal infections and increased longevity. However, new technologies need to be developed to comba… |
| Reversible | Guo et al · J Control Release | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | Because of its large surface area and easy access for both delivery and monitoring, the skin is an attractive target for gene therapy for cutaneous diseases, vaccinations and several metabol… |
| Reversible | Markelc et al · Gene Ther | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Gen Elektrotransferi (Plazmid DNA) | Electropermeabilization (EP) is an effective method of gene transfer into different tissues. During EP, reactive oxygen species (ROS) are formed, which could affect transfection efficiency. … |
| Reversible | Paganin-Gioanni et al · Proc Natl Acad Sci U S A | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | The RNA interference-mediated gene silencing approach is promising for therapies based on the targeted inhibition of disease-relevant genes. Electropermeabilization is one of the nonviral me… |
| Reversible | Rosazza et al · Mol Ther | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Electrotransfer of molecules is a well established technique which finds extensive use for gene transfer and holds great promise for anticancer treatment. Despite its widespread application,… |
| Reversible | Pucihar et al · IEEE Trans Biomed Eng | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | Electroporation-based applications require the use of specific pulse parameters for a successful outcome. When recommended values of pulse parameters cannot be set, similar outcomes can be o… |
| İrreversible | Garcia et al · Biomed Eng Online | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | Background: Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedu… |
| İrreversible | Li et al · PLoS One | 2011 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: If a critical nerve is circumferentially involved with tumor, radical surgery intended to cure the cancer must sacrifice the nerve. Loss of critical nerves may lead to serious co… |
| Reversible | Berg et al · Electromagn Biol Med | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Gen Elektrotransferi (Plazmid DNA) | We present possibilities and trends of ELF bioelectromagnetic effects in the mT amplitude range on cancer cells and on mice bearing tumors. In contrast to invasive electrochemotherapy and el… |
| Reversible | Fantozzi et al · Bioelectrochemistry | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | The achievement of electrochemotherapy was obtained using electrodes covered with guar gum (GG) hydrogel swollen in a sulfate bleomycin solution. The bleomycin delivery into the plasma membr… |
| Reversible | Lambreva et al · Bioelectrochemistry | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Two reliable methods have been combined: i) the electroporation of the cell membranes for facilitating the sensitizer incorporation into hystiocytic human lymphoma cells U-937 and (ii) the p… |
| Reversible | Gothelf et al · Gene Ther | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Elektrot Geometrisi ve Yerleşimi | Gene electrotransfer refers to gene transfection by electroporation and is an effective non-viral method for delivering naked DNA into cells and tissues. This study presents data from gene e… |
| Reversible | Reed et al · Cancer Gene Ther | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, İnterlökin-12 Aracılı İmmün Uyarım | On the basis of superior outcomes from electrochemogene therapy (ECGT) compared with electrochemotherapy in mice, we determined the efficacy of ECGT applied to spontaneous canine neoplasms. … |
| Reversible | Reed et al · Cancer Gene Ther | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, İnterlökin-12 Aracılı İmmün Uyarım | On the basis of superior outcomes from electrochemogenetherapy (ECGT) compared with electrochemotherapy in mice, we determined the efficacy of ECGT applied to spontaneous canine neoplasms. I… |
| İrreversible | Garcia et al · J Membr Biol | 2010 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive technique to treat cancer. It is unique because of its nonthermal mechanism of tumor ablation. Intracranial NTIRE … |
| Reversible | Hojman et al · PLoS One | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Erythropoietin can be over-expressed in skeletal muscles by gene electrotransfer, resulting in 100-fold increase in serum EPO and significant increases in haemoglobin levels. Earlier studies… |
| Reversible | Ivorra et al · Phys Med Biol | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | Electroporation is the phenomenon in which cell membrane permeability is increased by exposing the cell to short high-electric-field pulses. Reversible electroporation treatments are used in… |
| Reversible | Kranjc et al · Radiat Res | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy can potentiate the radiosensitizing effect of bleomycin, as shown in our previous studies. To bring this treatment closer to use in clinical practice, we evaluated the in… |
| Reversible | Mazères et al · J Control Release | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | For an effective tissue controlled electropermeabilization as requested for electrochemotherapy and electrogenotherapy, it is very important to have informations about the electric field dis… |
| Reversible | Tabassum et al · Spectrochim Acta A Mol Biomol Spectrosc | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | – | The homodinuclear C(16)H(30)N(8)O(5)Sn(2)Cl(4) (1), heterotetranuclear C(16)H(38)N(8)O(9)Sn(2)Cu(2)Cl(8) (2) and C(16)H(38)N(8)O(9)Sn(2)Mn(2)Cl(8) (3) macrocyclic complexes were synthesized … |
| Reversible | Wasungu et al · Int J Pharm | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electropermeabilization is a physical method to deliver molecules into cells and tissues. Clinical applications have been successfully developed for antitumoral drug delivery and clinical tr… |
| Reversible | Tevz et al · J Gene Med | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), İnterlökin-12 Aracılı İmmün Uyarım | Background: The present study aimed to evaluate the antitumor effectiveness of systemic interleukin (IL)-12 gene therapy in murine sarcoma models, and to evaluate its interaction with the ir… |
| Reversible | Cemazar et al · Gene Ther | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | Electrotransfer (electroporation) is recognized as one of the most promising alternatives to viral vectors for transfection of different tissues in vivo for therapeutic purposes. We evaluate… |
| İrreversible | Daniels et al · J Biomech Eng | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive surgical technique that is part of the emerging field of molecular surgery, which holds the potential to treat dis… |
| İrreversible | Granot et al · Phys Med Biol | 2009 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Electroporation, the increased permeability of cell membranes due to a large transmembrane voltage, is an important clinical tool. Both reversible and irreversible in vivo electroporation ar… |
| Reversible | Ivorra et al · Phys Med Biol | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | Electroporation is used in tissue for gene therapy, drug therapy and minimally invasive tissue ablation. The electrical field that develops during the application of the high voltage pulses … |
| Reversible | Larkin et al · Ultrasound Med Biol | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Bleomycin is a nonpermeant, hydrophilic macromolecule with a high intrinsic anticancer cytotoxicity. However, the cytotoxic potential of the drug is restricted by its low membrane permeabili… |
| Reversible | Čorović et al · Technol Cancer Res Treat | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemot… |
| Reversible | Tevz et al · Technol Cancer Res Treat | 2008 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Nekroz ve Nekroptoz | Skeletal muscle is an attractive target tissue for delivery of therapeutic genes, since it is well vascularized, easily accessible, and has a high capacity for protein synthesis. For efficie… |
| Reversible | Bicek et al · Bioelectrochemistry | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Ruthenium complex NAMI-A [ImH][trans-RuCl(4)(DMSO-S)Im] (Im = imidazole) is a potential chemotherapeutic drug in cancer treatment. Electroporation can be used to facilitate delivery of NAMI-… |
| Reversible | Pavlin et al · Biochim Biophys Acta | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | Electroporation is a process where increased permeability of cells exposed to an electric field is observed. It is used in many biomedical applications including electrogene transfection and… |
| Reversible | Hojman et al · BMC Mol Biol | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Background: Gene transfer by electroporation (DNA electrotransfer) to muscle results in high level long term transgenic expression, showing great promise for treatment of e.g. protein defici… |
| İrreversible | Al-Sakere et al · Technol Cancer Res Treat | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Immune cell recruitment during the treatment of sarcoma tumors in mice with irreversible electroporation was studied by immunohistochemistry. Irreversible electroporation is a non-thermal ti… |
| İrreversible | Lee et al · Technol Cancer Res Treat | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Apoptoz İndüksiyonu | Preliminary results of percutaneous irreversible electroporation (PIE) on swine liver as a novel non-thermal ablation are presented. The goal of this study was to evaluate the feasibility of… |
| İrreversible | Maor et al · Technol Cancer Res Treat | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | We present a pilot study on the long term effects of irreversible electroporation (IRE) on a large blood vessel. The study was motivated by the anticipated use of IRE for treatment of cancer… |
| İrreversible | Rubinsky et al · Technol Cancer Res Treat | 2007 | Hayvan Çalışması | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a new tissue ablation technique in which micro to millisecond electrical pulses are delivered to undesirable tissue to produce cell necrosis through irr… |
| Reversible | Cemazar et al · Anticancer Res | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | Background: The in vitro cytotoxic activity of two new platinum(II) complexes (3P-SK and PtAMP) in comparison with cisplatin (CDDP), oxaliplatin (OXA) and carboplatin (CARBO) was determined … |
| Reversible | Cemazar et al · Biochem Biophys Res Commun | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | Imaging methods can give both temporal and spatial dimensions to characterize the processes in progression of and/or treatment of specific disease Subcutaneous tumors can be cured after elec… |
| Reversible | Labanauskiene et al · Medicina (Kaunas) | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | By applying electric pulses to tumor the membrane of tumor cells undergoes destabilization that enables the drug molecules to enter into the cells more freely and selectivity of anticancer d… |
| Reversible | Mossop et al · Ann Biomed Eng | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi, Elektrik Alan Dağılımı ve Modellemesi | The intratumoral field, which determines the efficiency of electric field-mediated drug and gene delivery, can differ significantly from the applied field. Therefore, we investigated the dis… |
| Reversible | Shil et al · J Environ Pathol Toxicol Oncol | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Treatment of cancer patients is subject to limitations in radiotherapy and chemotherapy. This necessitates development of new protocols, and the present work reports on the effects of a comb… |
| Reversible | Soden et al · Cancer Lett | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | Electroporation is the application of very brief electric pulses to cells or tissues to render the cell membranes transiently and reversibly permeable, facilitating cellular uptake of otherw… |
| Reversible | Bloquel et al · BMC Biotechnol | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Background: Optical imaging is an attractive non-invasive way to evaluate the expression of a transferred DNA, mainly thanks to its lower cost and ease of realization. In this study optical … |
| Reversible | Herrero-Fresneda et al · Kidney Int | 2006 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA) | Inflammatory processes and tissue scarring are characteristic features of chronic allograft nephropathy. Hepatocyte growth factor (HGF) has beneficial effects on renal fibrosis and it also a… |
| Reversible | Larkin et al · Ir J Med Sci | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | – | SYLVESTER o'HALLORAN SURGICAL SCIENTIFIC MEETING • 4 - 5 MARCH 2005 • JEAN MONNET THEATRE, UNIVERSITY OF LIMERICK art" >,9R Modulation of coregulatory protein expression in human breast canc… |
| Reversible | Miklavčič et al · Bioelectrochemistry | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Kas Kasılması ve Anestezi Gereksinimi | Muscle contractions present the main source of unpleasant sensations for patients undergoing electrochemotherapy. The contractions are a consequence of high voltage pulse delivery. Relativel… |
| Reversible | Pavlin et al · Biophys J | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi | An increased permeability of a cell membrane during the application of high-voltage pulses results in increased transmembrane transport of molecules that otherwise cannot enter the cell. Inc… |
| Reversible | Šatkauskas et al · Bioelectrochemistry | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | The aim of this study was to evaluate the effectiveness of electrochemotherapy (ECT) as a function of various combinations of pulse strength and duration. C57Bl mice bearing LLC tumors were … |
| Reversible | Li et al · Mol Ther | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım, Gen Elektrotransferi (Plazmid DNA) | Injection of DNA via electric pulses into targeted tissues is referred to as electrotransfer. Intratumoral electrotransfer of the IL12 gene is more effective than intramuscular electrotransf… |
| Reversible | Soden et al · Conf Proc IEEE Eng Med Biol Soc | 2005 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi, Bleomisin Hücre İçi Birikiminin Artması | Therapeutic "electroporation" involves application of electric fields to target cells/tissues, thereby rendering their cell membranes transiently porous, thus making feasible the cellular up… |
| Reversible | Beebe et al · Physiol Meas | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Apoptoz İndüksiyonu | These studies describe the effects of nanosecond (10-300 ns) pulsed electric fields (nsPEF) on mammalian cell structure and function. As the pulse durations decrease, effects on the plasma m… |
| Reversible | Cemazar · BMC Cancer | 2004 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu, Gen Elektrotransferi (Plazmid DNA) | Background: Electroporation is currently receiving much attention as a way to increase drug and DNA delivery. Recent studies demonstrated the feasibility of electrogene therapy using a range… |
| Reversible | Kitamura · Cancer Chemother Pharmacol | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | Purpose: To determine whether or not low-voltage electrochemotherapy has cell killing effects. Materials: Dorsally transplanted NR-S1 carcinomas in mice were stimulated with electric pulses … |
| Reversible | Cemazar et al · DNA Cell Biol | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Sisplatin Hücre İçi Birikiminin Artması | The aim of our study was to evaluate electrogenetherapy with p53wt alone or combined with cisplatin on two colorectal (HT-29 and LoVo) and two prostatic (PC-3 and Du145) carcinoma cell lines… |
| Reversible | Ivanov et al · J Gene Med | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Background: MBD2 is a methylated DNA-binding protein that has been previously suggested to have transcriptional silencing as well as DNA demethylase activities. We have previously shown that… |
| Reversible | Miyazaki et al · Surg Today | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Purpose: The antitumor efficiency of electrochemotherapy using chemotherapeutic agents and high-voltage electric pulse has been reported. This study was done to define the precise nature of … |
| İrreversible | Beebe et al · DNA Cell Biol | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Nanosaniye Darbeli Elektrik Alan (nsPEF), Apoptoz İndüksiyonu | The application of pulsed electric fields to cells is extended to include nonthermal pulses with shorter durations (10-300 ns), higher electric fields (< or =350 kV/cm), higher power (gigawa… |
| İrreversible | Beebe et al · FASEB J | 2003 | Hayvan Çalışması | Hayvan (İn Vivo) | Apoptoz İndüksiyonu, Nanosaniye Darbeli Elektrik Alan (nsPEF) | Electroporation by using pulsed electric fields with long durations compared with the charging time of the plasma membrane can induce cell fusion or introduce xenomolecules into cells. Nanos… |
| Reversible | Dujardin · J Control Release | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Doku İletkenliği ve Empedans Değişimi | The application of short-duration high-voltage pulses to the skin has been shown to enhance transdermal drug delivery by several orders of magnitude and to transiently permeabilize cells in … |
| Reversible | Heller et al · Technol Cancer Res Treat | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Nekroz ve Nekroptoz | The efficient delivery of drugs to tumors is an important tool for the treatment of a variety of cancers. Electric pulses have been shown to facilitate the uptake of molecules through the ce… |
| Reversible | Mitsui et al · Drug Deliv | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | We investigated the cytotoxicity on the combination of bleomycin (BLM) with electric pulses against transplanted bladder tumors in nude mice. Loading with high-voltage electric pulse after i… |
| Reversible | Pucihar et al · Bioelectrochemistry | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | Electrochemotherapy is a technique where electric pulses in combination with chemotherapeutic agents are applied to tumor cells. In general, patients find electrochemotherapy tolerable, in s… |
| Reversible | Weaver · Bioelectrochemistry | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Scientific interest in the interaction of nonionizing electromagnetic fields with biological systems is longstanding, but often still controversial. Theories, models and computer simulations… |
| Reversible | Golzio et al · Proc Natl Acad Sci U S A | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Gen Elektrotransferi (Plazmid DNA) | Electropermeabilization is one of the nonviral methods successfully used to transfer genes into living cells in vitro and in vivo. Although this approach shows promise in the field of gene t… |
| Reversible | Li · J Natl Cancer Inst | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | İnterlökin-12 Aracılı İmmün Uyarım | Background Interleukin 12 (IL-12) is a proinflammatory cytokine with antitumor activity. Plasmid-based intratumoral gene therapy for treating malignancy with IL-12 or other genes is safe, in… |
| Reversible | Lebar et al · Anticancer Res | 2002 | Hayvan Çalışması | Hayvan (İn Vivo) | Darbe Parametrelerinin Optimizasyonu | The aim of our study was to optimise electric pulse parameters for electrochemotherapy by sampling the space of pulse parameter variables using systematic in vitro experiments. For this purp… |
| Reversible | Cemazar et al · Eur J Cancer | 2001 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması | The aim of the study was to determine whether electrochemotherapy with cisplatin could be implemented in treatment of cisplatin-resistant solid tumours. For this purpose, we used cisplatin-s… |
| Reversible | Serša et al · Int J Radiat Oncol Biol Phys | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Purpose: To evaluate whether a local drug delivery method, i.e., electroporation of tumors, increases the radiosensitizing effect of cisplatin. Methods and materials: Subcutaneous Ehrlich-Le… |
| Reversible | Goto et al · Proc Natl Acad Sci U S A | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | We report successful electro-gene therapy (EGT) by using plasmid DNA for tumor-bearing mice. Subcutaneously inoculated CT26 tumor was subjected to EGT, which consists of intratumoral injecti… |
| Reversible | Miklavčič et al · Biochim Biophys Acta | 2000 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Permeabilising electric pulses can be advantageously used for DNA electrotransfer in vivo for gene therapy, as well as for drug delivery. In both cases, it is essential to know the electric … |
| Reversible | Cemazar et al · Br J Cancer | 1999 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | Electrochemotherapy is an anti-tumour treatment that utilizes locally delivered electric pulses to increase cytotoxicity of chemotherapeutic drugs. The aim of our study was to determine whet… |
| Reversible | Sersa et al · Anticancer Res | 1999 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Vasküler Kilit (Vascular Lock) Etkisi | Background: Electrochemotherapy combines administration of the chemotherapeutic drug, followed by application of electric pulses in order to increase drug delivery into the cells. The aim of… |
| Reversible | Mir et al · Proc Natl Acad Sci U S A | 1999 | Hayvan Çalışması | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | Gene delivery to skeletal muscle is a promising strategy for the treatment of muscle disorders and for the systemic secretion of therapeutic proteins. However, present DNA delivery technolog… |
| Reversible | Gehl et al · Anticancer Drugs | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Electropermeabilization (EPN), also termed electroporation, is a physical method to overcome the barrier of the cell membrane by applying short and intense electric pulses. It is the basis f… |
| Reversible | Neumann et al · Biophys J | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | The color change of electroporated intact immunoglobulin G receptor (Fc gammaR-) mouse B cells (line IIA1.6) after direct electroporative transfer of the dye SERVA blue G (Mr 854) into the c… |
| Reversible | Čemazar et al · Anticancer Drugs | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Sisplatin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | Electrochemotherapy using intratumoral cisplatin administration was tested on EAT tumors in mice. Mice were treated with eight electric pulses (100 micros, 1 Hz, 1040 V) and/or cisplatin (1,… |
| Reversible | Čemažar et al · Jpn J Cancer Res | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) involves the use of locally applied electric pulses to increase delivery of chemotherapeutic drugs into cells in tissues. ECT with bleomycin (BLM) is a very effecti… |
| Reversible | Šemrov et al · Comput Biol Med | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Electrochemotherapy is a novel approach in chemotherapeutic drug delivery into tumours. Short intense direct current electric pulses are applied to tumour tissue causing electropermeabilisat… |
| Reversible | Miklavčič et al · Biophys J | 1998 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | Cells exposed to short and intense electric pulses become permeable to a number of various ionic molecules. This phenomenon was termed electroporation or electropermeabilization and is widel… |
| Reversible | Serša et al · Cancer Lett | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tum… |
| Reversible | Serša et al · Magn Reson Med | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Doku İletkenliği ve Empedans Değişimi, Elektrot Geometrisi ve Yerleşimi | The use of electric current density imaging (CDI) to map spatial distribution of electric currents through tumors is presented. Specifically, a method previously tested on phantoms was imple… |
| Reversible | Gilbert et al · Biochim Biophys Acta | 1997 | Hayvan Çalışması | Hayvan (İn Vivo) | Elektrot Geometrisi ve Yerleşimi | Direct current pulses for electrochemotherapy treatment are typically administered using two parallel plate electrodes that are placed on either side of the tumor. This simple design has pro… |
| Reversible | Jaroszeski et al · Melanoma Res | 1996 | Hayvan Çalışması | Hayvan (İn Vivo) | – | Electrochemotherapy has been demonstrated to be an effective treatment for cutaneous cancers. The treatment includes administering a chemotherapeutic agent followed by electric pulses which … |
| Reversible | Serša et al · Bioelectrochemistry and Bioenergetics | 1996 | Hayvan Çalışması | Hayvan (İn Vivo) | Transmembran Potansiyel Değişimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy is a new and promising approach in treatment of tumors employing locally applied high voltage d.c. electric pulses in combination with chemotherapeutic drugs. Increased p… |
| Reversible | Sersa et al · Anticancer Drugs | 1996 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy is an antitumor treatment that utilizes locally delivered electric pulses to increase the effectiveness of chemotherapeutic drugs in cells and tissues. Electric pulses pe… |
| Reversible | Sersa et al · Cancer Res | 1995 | Hayvan Çalışması | Hayvan (İn Vivo) | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Darbe Parametrelerinin Optimizasyonu | One of the ways to increase drug delivery into cells and tissues is by a local application of short, intense electric pulses, i.e., electropermeabilization. This approach is used in electroc… |
| Reversible | Serša et al · Bioelectrochemistry and Bioenergetics | 1994 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy is a new approach in the treatment of tumors that takes advantage of the permeabilization of the cell membrane by electric pulses to facilitate the delivery of chemothera… |
| Reversible | M Belehradek, C Domenge, B Luboinski, S Orlowski, J Belehradek, L Mir · Cancer | 1993 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy is a new antitumor treatment consisting of electrical pulses administered to the tumor several minutes after intravenous injection of bleomycin. In mice, important antitu… |
| Reversible | Serša et al · Cancer Lett | 1993 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrotherapy was investigated for its ability to increase the responsiveness of murine tumors to bleomycin treatment. Mice bearing fibrosarcoma were treated with 250 micrograms bleomycin a… |
| Reversible | Mir et al · Eur J Cancer | 1991 | Hayvan Çalışması | Hayvan (İn Vivo) | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | In cell culture the cytotoxicity of some anticancer drugs, especially bleomycin, can be greatly enhanced by exposing cells to non-cytotoxic electric pulses. Nude or conventional mice bearing… |
| Reversible | Alkis et al · Bioorg Chem | 2026 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | A novel niraparib-derived Schiff base (Sb) ligand and its Pd(II) and Fe(II) complexes were synthesized and comprehensively characterized using elemental and thermal analyses, 1 H, 13 C NMR, … |
| Reversible | Giovannini et al · Bioelectrochemistry | 2026 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electroporation is a promising technique for enhancing the delivery of therapeutic agents by transiently increasing cell membrane permeability through high-amplitude (from hundreds of V/cm t… |
| Reversible | Gürsoy et al · Cukurova Med J | 2026 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Apoptoz İndüksiyonu | Purpose: This study aimed to evaluate the effects of calcium electroporation on cell viability, energy metabolism, and cell survival signaling pathways in the colon cancer cell line DLD-1.Ma… |
| Reversible | Inglot et al · Chemistry | 2026 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Elektrik Alan Dağılımı ve Modellemesi | Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that combines a photosensitizer, light of an appropriate wavelength, and molecular oxygen to generate cytotoxic reacti… |
| Reversible | Neville et al · Radiol Oncol | 2026 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | Background: Reversible electroporation involves the use of pulsed electric fields to temporarily disrupt and permeabilise cell membranes. Electroporation combined with chemotherapy - electro… |
| Reversible | Xia et al · Bioelectrochemistry | 2026 | İn Vitro Çalışma | Hücre Kültürü | Termal Etki ve Joule Isınması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Microneedle electroporation holds promise for enhancing dermal gene and drug delivery, yet the biophysical consequences of millisecond exponential-decay pulses remain incompletely characteri… |
| Reversible | Zhou et al · Bio-des. Manuf. | 2026 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Reversible electroporation (RE) involves applying pulsed electric fields to briefly disrupt cell membrane channels, allowing molecular transfer while preserving cell viability. Advances in R… |
| İrreversible | Batista Napotnik et al · Sci Rep | 2026 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Kalsiyum Homeostazının Bozulması | In recent years, irreversible electroporation has been increasingly used to treat cardiac arrhythmias, an approach termed pulsed field ablation. The mechanisms of how electroporation affects… |
| İrreversible | Guo et al · Current Opinion in Electrochemistry | 2026 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, İrreversible Por Oluşumu ve Hücre Ölümü | of operating conditions for selected tumor inhibition techniques. Techniques Electrochemical therapy [2,10] Irreversible electroporation (IRE) [1,11] Electroporation and electrolysis [2] Mec… |
| İrreversible | Han et al · Biomater Res | 2026 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) remodels the tumor microenvironment to enhance biomaterial and nanoparticle (NP) delivery and immune activation, making combinational IRE-nanomedicine a pr… |
| İrreversible | Liu et al · iRADIOLOGY | 2026 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is an emerging tumor ablation technique that induces permanent damage to cellular membranes through the application of high‐intensity short‐duration electr… |
| Reversible | Plešnik et al · J Pharm Biomed Anal | 2025 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | Bleomycin, a cytotoxic antibiotic, poses substantial challenges for mass spectrometry-based analysis due to its extreme polarity, chelating properties, heterogeneity of fractions, and propen… |
| Reversible | Yetişsin et al · Artvin Çoruh Üniversitesi Orman Fakültesi Dergisi | 2025 | İn Vitro Çalışma | Hücre Kültürü | – | The aim of the current study was to determine the phenolic substances in the stem of Asparagus officinalis L, leaves of Arum elongatum Steven and Urtica dioica L. plants collected from diffe… |
| İrreversible | Wang et al · Bioelectrochemistry | 2025 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu, Mitokondriyal Disfonksiyon ve Oksidatif Stres | Sirtuin proteins have key roles in cancer progression and metastases. However, their role in bioelectrical modulation via high-frequency irreversible electroporation (H-FIRE) remains poorly … |
| Reversible | Choromańska et al · Biochim Biophys Acta Gen Subj | 2024 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | Although the pulse electric field (PEF) has been used in electrochemotherapy (ECT) for many years, the kinetics and profile of extracellular particles (EPs) released as a result of reversibl… |
| Reversible | Coskun et al · Bioelectricity | 2024 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi | Electrochemotherapy (ECT) involves locally applying electrical pulses to permeabilize cell membranes, using electroporation (EP). This process enhances the uptake of low-permeant chemotherap… |
| Reversible | Lisec · Cell Commun Signal | 2024 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Kalsiyum Homeostazının Bozulması | Background: Disruption of Ca 2+ homeostasis after calcium electroporation (CaEP) in tumors has been shown to elicit an enhanced antitumor effect with varying impacts on healthy tissue, such … |
| Reversible | Lopes et al · Med Eng Phys | 2024 | İn Vitro Çalışma | Hücre Kültürü | Elektrot Geometrisi ve Yerleşimi, Elektrik Alan Dağılımı ve Modellemesi | Electrochemotherapy is a cancer treatment in which local pulsed electric fields are delivered through electrodes. The effectiveness of the treatment depends on exposing the tumor to a thresh… |
| Reversible | Mondal et al · J Membr Biol | 2024 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversi… |
| Reversible | Radzevičiūtė-Valčiukė et al · Bioelectrochemistry | 2024 | İn Vitro Çalışma | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Reversible Membran Permeabilizasyonu | Calcium electroporation is a modality of electrochemotherapy (ECT), which is based on intracellular electric field-mediated delivery of cytotoxic doses of calcium into the cells resulting in… |
| Reversible | Zamuner et al · Bioelectrochemistry | 2024 | İn Vitro Çalışma | Hücre Kültürü | Ekstraselüler Matriks ve Doku İskeletinin Korunması, Transmembran Potansiyel Değişimi | Electrochemotherapy (ECT) with bleomycin is an effective antitumor treatment. Still, researchers are investigating new drugs and electroporation conditions to improve its efficacy. To this a… |
| İrreversible | Lv et al · IEEE Trans Biomed Eng | 2024 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Unlabelled: The H-FIRE (high-frequency irreversible electroporation) protocol employs high-frequency bipolar pulses (HFBPs) with a width of ∼1 µs for tumor ablation with slight muscle contra… |
| Reversible | Kranjc et al · Int J Mol Sci | 2023 | İn Vitro Çalışma | Hücre Kültürü | İmmünojenik Hücre Ölümü (ICD), Gen Elektrotransferi (Plazmid DNA) | High-Intensity Pulsed Electromagnetic Fields (HI-PEMF) treatment is an emerging noninvasive and contactless alternative to conventional electroporation, since the electric field inside the t… |
| Reversible | Lin et al · Talanta | 2023 | İn Vitro Çalışma | Hücre Kültürü | Ekstraselüler Matriks ve Doku İskeletinin Korunması | Cell density is important for tumour metastasis, treatment and prognosis. Characterizing changes in cell density for electrochemotherapy (ECT) can reveal sub-populations in pathological stat… |
| Reversible | Rembiałkowska et al · Int J Pharm | 2023 | İn Vitro Çalışma | Hücre Kültürü | Nanosaniye Darbeli Elektrik Alan (nsPEF), Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Drug delivery using nanosecond pulsed electric fields is a new branch of electroporation-based treatments, which potentially can substitute European standard operating procedures for electro… |
| Reversible | Rembiałkowska et al · Int J Pharm | 2023 | İn Vitro Çalışma | Hücre Kültürü | Nanosaniye Darbeli Elektrik Alan (nsPEF), Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) involves combining anticancer drugs with electroporation, which is induced by pulsed electric fields (PEFs), while the effects vary in effectiveness based on the sp… |
| Reversible | Komel et al · Bioelectrochemistry | 2023 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | Fluorescent reporter genes are widely used to study the transfection of various types of primary cells and cell lines. The aim of our research was to investigate the expression dynamics of G… |
| Reversible | Polajžer et al · Vaccines (Basel) | 2023 | İn Vitro Çalışma | Hücre Kültürü | İmmünojenik Hücre Ölümü (ICD), Darbe Parametrelerinin Optimizasyonu | Traditionally, electroporation-based therapies such as electrochemotherapy (ECT), gene electrotransfer (GET) and irreversible electroporation (IRE) are performed with different but typical p… |
| Reversible | de Caro et al · Pharmaceutics | 2023 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | Electroporation, a method relying on a pulsed electric field to induce transient cell membrane permeabilization, can be used as a non-viral method to transfer genes in vitro and in vivo. Suc… |
| Reversible | Vélez Salazar et al · Biophys J | 2023 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Vasküler Kilit (Vascular Lock) Etkisi | The convective delivery of chemotherapeutic drugs in cancerous tissues is directly proportional to the blood perfusion rate, which in turns can be transiently reduced by the application of h… |
| Reversible | Andrade et al · Sci Rep | 2022 | İn Vitro Çalışma | Hücre Kültürü | Elektrot Geometrisi ve Yerleşimi | Electrochemotherapy is a selective electrical-based cancer treatment. A thriving treatment depends on the local electric field generated by pairs of electrodes. Electrode damage as deflectio… |
| Reversible | Gursoy et al · Med Oncol | 2022 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Low-dose chemotherapy in advanced stages of cancer does not give a positive response in treatment. The use of high-dose antineoplastic drugs creates significant side effects. The limiting si… |
| Reversible | Lv et al · Bioelectrochemistry | 2022 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Electroporation achieved by the application of pulsed electric field is successfully used for clinical tumor ablation. Electrochemotherapy (ECT) and irreversible electroporation (IRE), which… |
| Reversible | Watanabe et al · Sensors (Basel) | 2022 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Doku İletkenliği ve Empedans Değişimi | Membrane permeabilization stimulated by high-voltage electric pulses has been used to deliver cell-impermeable exogenous molecules. The electric field effect on the cells depends on various … |
| İrreversible | Petrella et al · IEEE Trans Biomed Eng | 2022 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Expanding the volume of an irreversible electroporation treatment typically necessitates an increase in pulse voltage, number, duration, or repetition. This study investigates the addition o… |
| Reversible | Alkış et al · Journal of Molecular Structure | 2021 | İn Vitro Çalışma | Hücre Kültürü | – | In this study, a new Schiff base ligand and its two M(II) complexes [CoCl·L(H2 O)2 ]·2H2 O, [RuCl(pcymene)L] were synthesized. The structural features were confirmed from their micro analytic… |
| Reversible | Lira et al · Adv Sci (Weinh) | 2021 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | Resealing of membrane pores is crucial for cell survival. Membrane surface charge and medium composition are studied as defining regulators of membrane stability. Pores are generated by elec… |
| Reversible | Lopes et al · Med Eng Phys | 2021 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | Electrochemotherapy (ECT) requires covering the entire tumor and safe margins with a suitable pulsed electric field (PEF). The PEF distribution depends on the biological and electrical param… |
| Reversible | Yadegari-Dehkordi et al · Cell J | 2021 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Reversible Membran Permeabilizasyonu | Objective: The cell membrane is a major barrier for delivery of hydrophilic drugs and molecules into the cells. Although low voltage and high frequency electric fields (LVHF) are proposed to… |
| İrreversible | Alinezhadbalalami et al · Bioelectrochemistry | 2021 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Expansion of cytotoxic T lymphocytes (CTLs) is a crucial step in almost all cancer immunotherapeutic methods. Current techniques for expansion of tumor-reactive CTLs present major limitation… |
| İrreversible | Hanson et al · Sci Rep | 2021 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is used clinically as a focal therapy to ablate solid tumors. A critical disadvantage of IRE as a monotherapy for cancer is the inability of ablating large… |
| Reversible | Fiorentzis et al · J Vis Exp | 2020 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Darbe Parametrelerinin Optimizasyonu | Electrochemotherapy (ECT) is the combination of transient pore formation following electric pulse application with the administration of cytotoxic drugs, which enhances the cytotoxic effect … |
| Reversible | Rems et al · Biophys J | 2020 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | Pulsed electric fields are increasingly used in medicine to transiently increase the cell membrane permeability via electroporation to deliver therapeutic molecules into the cell. One type o… |
| Reversible | Sözer et al · Biophys J | 2020 | İn Vitro Çalışma | Hücre Kültürü | – | Although transport of molecules into cells via electroporation is a common biomedical procedure, its protocols are often based on trial and error. Despite a long history of theoretical effor… |
| Reversible | Wolff et al · Cancers (Basel) | 2020 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres, Reversible Membran Permeabilizasyonu | New approaches in oncotherapy rely on the combination of different treatments to enhance the efficacy of established monotherapies. Pulsed electric fields (PEFs) are an established method (e… |
| Reversible | Youssef et al · Mathematics | 2020 | İn Vitro Çalışma | Hücre Kültürü | Termal Etki ve Joule Isınması | The essential target of the tumor’s treatment is how to destroy its tissues. This work is dealing with the thermal damage of the tumor tissue due to the thermoelectrical effect based on the … |
| İrreversible | Lv et al · IEEE Trans Biomed Eng | 2020 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Unlabelled: Irreversible electroporation (IRE) employs brief, high-electric field pulses to ablate tumors while preserving the extracellular matrix. Recently, we showed that combining short … |
| Reversible | Brun et al · Bioelectrochemistry | 2019 | İn Vitro Çalışma | Hücre Kültürü | Ekstraselüler Matriks ve Doku İskeletinin Korunması | Electroporation of cells is usually studied using cell suspensions or monolayer cultures. 3D scaffolds for cell culture have been recently designed in order to reproduce in vitro the complex… |
| Reversible | DRĄG-ZALESIŃSKA et al · Anticancer Res | 2019 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Apoptoz İndüksiyonu | Background/aim: Small cell lung cancer (SCLC) originates from neuroendocrine branchial cells (15-20%). It is regarded as distinct from other lung cancers due to its biological and clinical f… |
| Reversible | Mączyńska et al · Oncol Rep | 2019 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Betulinic acid (BTA) is naturally occurring triterpene that has received interest as a novel therapeutic substance with cytotoxicity towards a number of cancer cell lines. Despite the wide s… |
| İrreversible | Ren et al · Int J Hyperthermia | 2019 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | Introduction: Irreversible electroporation (IRE) combined with a catheter-based electrode during endoscopy is a potential alternative treatment method for digestive tract tumors. The aim of … |
| İrreversible | Yang et al · PLoS One | 2018 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | Purpose: The aim of this study was to develop a statistical model for cell death by irreversible electroporation (IRE) and to show that the statistic model is more accurate than the electric… |
| Reversible | Bonakdar et al · RSC Adv | 2017 | İn Vitro Çalışma | Hücre Kültürü | Kan-Beyin Bariyeri Geçirgenliğinin Artması, Reversible Membran Permeabilizasyonu | Pulsed electric fields interact with the blood-brain barrier (BBB) and have been shown to increase the BBB permeability under some pulsing regimes. Pulsed electric fields may enhance drug de… |
| Reversible | Hanna et al · Stem Cell Res Ther | 2017 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | Background: Human mesenchymal stem cells are promising tools for regenerative medicine due to their ability to differentiate into many cellular types such as osteocytes, chondrocytes and adi… |
| İrreversible | Labarbera et al · Theor Biol Med Model | 2017 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, İrreversible Por Oluşumu ve Hücre Ölümü | Background: One recent area of cancer research is irreversible electroporation (IRE). Irreversible electroporation is a minimally invasive procedure where needle electrodes are inserted into… |
| Reversible | DiGiusto et al · Mol Ther Methods Clin Dev | 2016 | İn Vitro Çalışma | Hücre Kültürü | – | Gene therapy for HIV-1 infection is a promising alternative to lifelong combination antiviral drug treatment. Chemokine receptor 5 (CCR5) is the coreceptor required for R5-tropic HIV-1 infec… |
| Reversible | Esmekaya et al · J Membr Biol | 2016 | İn Vitro Çalışma | Hücre Kültürü | Sisplatin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrochemotherapy is the usage of electroporation to introduce chemotherapeutic drugs through membrane pores into target cells for cancer treatment. The effectiveness of chemotherapeutic d… |
| Reversible | Frandsen et al · J Membr Biol | 2016 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | Electroporation-based treatments and other therapies that permeabilize the plasma membrane have been shown to be more devastating to malignant cells than to normal cells. In this study, we a… |
| Reversible | Lesueur et al · Mol Ther Nucleic Acids | 2016 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA) | Gene electrotransfer is a safe and efficient nonviral technique for the transfer of nucleic acids of all sizes. Using a small reporter plasmid (3.5 kbp), electrotransfer of more than 90% of … |
| Reversible | Denzi et al · J Membr Biol | 2016 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Gen Elektrotransferi (Plazmid DNA) | Over the past decades, the effects of ultrashort-pulsed electric fields have been used to investigate their action in many medical applications (e.g. cancer, gene electrotransfer, drug deliv… |
| Reversible | Landström et al · Anticancer Res | 2015 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Aim: Electrochemotherapy (ECT) is a new cancer treatment modality that uses electroporation to potentiate chemotherapeutic agents, especially bleomycin. ECT causes both a direct toxic effect… |
| Reversible | Madi et al · J Membr Biol | 2015 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | DNA electrotransfer is a successful technic for gene delivery. However, its use in clinical applications is limited since little is known about the mechanisms governing DNA electrotransfer i… |
| Reversible | Zielichowska et al · Biomed Pharmacother | 2015 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | Introduction: Electroporation (EP) is commonly applied for effective drug transport thorough cell membranes based on the application of electromagnetic field. When applied with cytostatics, … |
| Reversible | Garcia et al · PLoS One | 2014 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Electroporation-based therapies are powerful biotechnological tools for enhancing the delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs). Electrochemotherapy … |
| Reversible | Lekner · Phys Med Biol | 2014 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu | Electroporation in cancer therapy in which elongated micron-sized conductors are used to enhance an externally applied electric field is investigated. Such field enhancement was previously u… |
| Reversible | Meulenberg et al · Toxicol In Vitro | 2014 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | The aim of this study was to develop an in vitro cell model for studying the in vivo observed vascular effect, induced by exposing blood vessels to changing electric field strengths. Human m… |
| Reversible | Reigada · Biochim Biophys Acta | 2014 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electroporation is the basis for the transfection of genetic material and for drug delivery to cells, including electrochemotherapy for cancer. By means of molecular dynamics many aspects of… |
| Reversible | Guo et al · Mol Ther Methods Clin Dev | 2014 | İn Vitro Çalışma | Hücre Kültürü | Nanosaniye Darbeli Elektrik Alan (nsPEF), Gen Elektrotransferi (Plazmid DNA) | The impact of nanosecond pulsed electric fields (nsPEFs) on gene electrotransfer has not been clearly demonstrated in previous studies. This study was conducted to evaluate the influence of … |
| İrreversible | Colacino et al · Technol Cancer Res Treat | 2014 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Cellulose nanocrystals are rod-shaped, crystalline nanoparticles that have shown prom-ise in a number of industrial applications for their unique chemical and physical properties. However, i… |
| İrreversible | Jourabchi et al · Gastrointestinal Intervention | 2014 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a promising new minimally invasive modality for the ablation of solid tumors. Unlike the current leading thermal ablation modalities, such as radiofrequ… |
| Reversible | Bagheri et al · J Biomed Phys Eng | 2013 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Antivasküler Etki ve Damar Yıkımı | Unlabelled: Propose: Standard electroporation and electrochemotherapy caused the endothelial cell permeability and reduction in tumor blood flow. The effects of low voltage and high frequenc… |
| Reversible | Beebe et al · Cells | 2013 | İn Vitro Çalışma | Hücre Kültürü | Nanosaniye Darbeli Elektrik Alan (nsPEF), Apoptoz İndüksiyonu | Pulse power technology using nanosecond pulsed electric fields (nsPEFs) offers a new stimulus to modulate cell functions or induce cell death for cancer cell ablation. New data and a literat… |
| Reversible | Gibot et al · J Control Release | 2013 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Electrochemotherapy (ECT) is a physical technique that allows cytotoxic molecules to be efficiently released in tumor cells by inducing transient cell plasma membrane permeabilization. The m… |
| Reversible | Mansourian et al · Electromagn Biol Med | 2013 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Apoptoz İndüksiyonu | Nowadays, due to the wide use of mobile phones, extensive studies have been carried out on the effects of magnetic field (MF) on public health. In this paper, we study the effect of 217 Hz M… |
| İrreversible | Xiao et al · Bioelectromagnetics | 2013 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Apoptoz İndüksiyonu | The goal of this study was to assess the effect of nanosecond electric pulses on HepG2 human liver cancer cells. Electric pulses with a high strength of 10 kV/cm, duration of 500 ns and freq… |
| Reversible | Escoffre et al · curr pharm des | 2012 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Treatment of recurrent or unresectable cutaneous and subcutaneaous tumors continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a palliative treatment of cutaneous and … |
| Reversible | Ghiasi et al · Int J Biomed Sci | 2012 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Elektrot Geometrisi ve Yerleşimi | The Electrochemotherapy (ECT) is an effective treatment of cutaneous and subcutaneous solid tumors. Electric field is applied to tumor nodules to enhance the delivery/distribution of a non-p… |
| Reversible | Ren et al · Biochem Biophys Res Commun | 2012 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu, Nanosaniye Darbeli Elektrik Alan (nsPEF) | NsPEF ablation induces apoptosis markers, but specific cell death pathways have not been fully defined. To identify nsPEF-activated cell death pathways, wildtype human Jurkat cells and clone… |
| Reversible | Towhidi et al · Radiol Oncol | 2012 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu | Background: The cell membrane acts as a barrier that hinders free entrance of most hydrophilic molecules into the cell. Due to numerous applications in medicine, biology and biotechnology, t… |
| İrreversible | Xiong et al · J Cancer Res Ther | 2012 | İn Vitro Çalışma | Hücre Kültürü | Apoptoz İndüksiyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Background: High-voltage electric field pulses can make cell membrane electroporated irreversibly and eliminate malignant cells via necrosis. However, low-voltage is not efficient as that. A… |
| Reversible | Pakhomova · PLoS One | 2011 | İn Vitro Çalışma | Hücre Kültürü | Darbe Parametrelerinin Optimizasyonu, Reversible Membran Permeabilizasyonu | Background: Electroporation is a method of disrupting the integrity of cell membrane by electric pulses (EPs). Electrical modeling is widely employed to explain and study electroporation, bu… |
| Reversible | Skolucka et al · Asian Pac J Trop Biomed | 2011 | İn Vitro Çalışma | Hücre Kültürü | Mitokondriyal Disfonksiyon ve Oksidatif Stres | Objective: To estimate electroporation (EP) influence on malignant and normal cells. Methods: Two cell lines including human malignant melanoma (Me-45) and normal human gingival fibroblast (… |
| Reversible | Stacey et al · Bioelectrochemistry | 2011 | İn Vitro Çalışma | Hücre Kültürü | Nanosaniye Darbeli Elektrik Alan (nsPEF) | We investigated the effects of nanosecond pulsed electric fields (nsPEF) on three human cell lines and demonstrated cell shrinkage, breakdown of the cytoskeleton, nuclear membrane and chromo… |
| İrreversible | Golberg et al · Biomed Eng Online | 2010 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Irreversible electroporation (IRE) is a minimally invasive tissue ablation technique which utilizes electric pulses delivered by electrodes to a targeted area of tissue to produc… |
| Reversible | Choi et al · Anal Chem | 2009 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Elektrik Alan Dağılımı ve Modellemesi | A microfabricated cell-based testing device for electrochemotherapy (ECT) has been developed; it mimics a clinical electroporator with a circular needle array and maintains a similar electri… |
| Reversible | Hu et al · Phys Rev E Stat Nonlin Soft Matter Phys | 2009 | İn Vitro Çalışma | Hücre Kültürü | Transmembran Potansiyel Değişimi, Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Self-consistent evaluations of both the transmembrane potential (TMP) and possible electroporation density across membrane of spheroidal cells in response to ultrashort, high-intensity pulse… |
| İrreversible | Shafiee et al · J Biomech Eng | 2009 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | Intense but short electrical fields can increase the permeability of the cell membrane in a process referred to as electroporation. Reversible electroporation has become an important tool in… |
| Reversible | Böckmann et al · Biophys J | 2008 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi | Membrane electroporation is the method to directly transfer bioactive substances such as drugs and genes into living cells, as well as preceding electrofusion. Although much information on t… |
| Reversible | He et al · Bioelectrochemistry | 2008 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Doku İletkenliği ve Empedans Değişimi | This paper presents a novel method to measure the dynamic process of membrane permeability during electroporation (EP) on microchips for human cancer cells. Micro EP chips with three-dimensi… |
| Reversible | Kandušer et al · Bioelectrochemistry | 2008 | İn Vitro Çalışma | Hücre Kültürü | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | Cell membrane permeabilization is caused by the application of high intensity electric pulses of short duration. The extent of cell membrane permeabilization depends on electric pulse parame… |
| Reversible | Choi et al · Biomed Microdevices | 2008 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi, Bleomisin Hücre İçi Birikiminin Artması | A microfabricated cell-based testing device for electrochemotherapy (ECT) has been developed by miniaturizing the widely used clinical electroporator with a two-needle array into two-dimensi… |
| Reversible | Pliquett et al · IEEE Trans Biomed Eng | 2007 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Elektrot Geometrisi ve Yerleşimi | Electrical creation of aqueous pathways across the skin's outer layer [stratum corneum (SC)] provides an approach to transdermal delivery of medium-size water-soluble compounds. However, ner… |
| Reversible | Xu et al · Bioelectrochemistry | 2007 | İn Vitro Çalışma | Hücre Kültürü | – | In this paper, it was reported for the first time that the combination of the electroporation and the conjugation of the TiO(2) nanoparticles with the monoclonal antibody could improve the p… |
| Reversible | Čorović et al · Biomed Eng Online | 2007 | İn Vitro Çalışma | Hücre Kültürü | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | Background: Electrochemotherapy and gene electrotransfer are novel promising treatments employing locally applied high electric pulses to introduce chemotherapeutic drugs into tumor cells or… |
| Reversible | Reberšek et al · Biomed Eng Online | 2007 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Reversible Membran Permeabilizasyonu | Background: Gene electrotransfer is a non-viral method used to transfer genes into living cells by means of high-voltage electric pulses. An exposure of a cell to an adequate amplitude and d… |
| Reversible | Kanthou et al · Mol Cancer Ther | 2006 | İn Vitro Çalışma | Hücre Kültürü | Gen Elektrotransferi (Plazmid DNA), Antivasküler Etki ve Damar Yıkımı | Electroporation-based therapies, such as electrochemotherapy and electrogene therapy, result in the disruption of blood vessel networks in vivo and cause changes in blood flow and vascular p… |
| Reversible | Miklavcic et al · European Journal of Cancer Supplements | 2006 | İn Vitro Çalışma | Hücre Kültürü | – | ctric field for effective electrochemotherapy Damijan Miklavcic*, Selma Corovic, Gorazd Pucihar, Natasa Pavselj Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, SI-1… |
| İrreversible | Miller et al · Technol Cancer Res Treat | 2005 | İn Vitro Çalışma | Hücre Kültürü | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | In this study we perform in vitro irreversible electroporation (IRE) experiments with human hepatocarcinoma cells (HepG2) to investigate IRE as a new technique for undesirable tissue ablatio… |
| Reversible | Pavlin et al · Biophys J | 2003 | İn Vitro Çalışma | Hücre Kültürü | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | During the electroporation cell membrane undergoes structural changes, which increase the membrane conductivity and consequently lead to a change in effective conductivity of a cell suspensi… |
| Reversible | Jaroszeski et al · Anticancer Drugs | 2000 | İn Vitro Çalışma | Hücre Kültürü | Bleomisin Hücre İçi Birikiminin Artması, Sisplatin Hücre İçi Birikiminin Artması | Electroporation is a physical event that temporarily reduces cell membrane barrier properties. Diminished membrane barrier properties are achieved by exposing cells to pulsed electric fields… |
| Reversible | Jaroszeski et al · Adv Drug Deliv Rev | 1997 | İn Vitro Çalışma | Hücre Kültürü | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Bleomisin Hücre İçi Birikiminin Artması | The combined treatment consisting of a chemotherapeutic agent and pulsed electric fields has been termed electrochemotherapy. This relatively new treatment modality relies on the physical ef… |
| Reversible | Sharma et al · Biophys J | 1996 | İn Vitro Çalışma | Hücre Kültürü | Transmembran Potansiyel Değişimi | The effect of a nontoxic, nonionic block co-polymeric surface active agent, poloxamer 188, on electroporation of artificial lipid membranes made of azolectin, was investigated. Two different… |
| Reversible | Mir et al · Bioelectrochemistry and Bioenergetics | 1995 | İn Vitro Çalışma | Hücre Kültürü | – | Short and intense electric pulses (EP) are regularly used in almost all molecular and cellular biology laboratories to introduce foreign DNA, as well as other exogeneous molecules, into livi… |
| Reversible | Borbála Fülöp et al · J Theor Biol | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | Electroporation-based therapies such as electrochemotherapy (ECT) hold a great promise for improving cancer treatments. While highly effective for superficial tumours, its application for de… |
| Reversible | Sherif et al · Sci Rep | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | This study presents a comprehensive computational and experimental investigation of the integrated dielectrophoresis (DEP) and electroporation framework for the selective manipulation and co… |
| Reversible | Vélez Salazar et al · Front Bioinform | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Vasküler Kilit (Vascular Lock) Etkisi | Drug administration via the bloodstream involves some transport and reaction mechanisms ( R T M s ), such as extravasation, perfusion along blood vessels, transmembrane and interstitial tran… |
| Reversible | Bernardini et al · COMPEL - The international journal for computation and mathematics in electrical and electronic engineering | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | Purpose This study aims to present a numerical model to predict the electric field distribution in the presence of conductive or dielectric nanoparticles close to the cell membrane during el… |
| İrreversible | Chen et al · IEEE Trans Biomed Eng | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | Objective: Asymmetric pulse waveforms represent an optimized treatment protocol for high-frequency irreversible electroporation (H-FIRE), offering a lower ablation threshold compared to symm… |
| İrreversible | Cheng et al · Ann Biomed Eng | 2026 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Doku İletkenliği ve Empedans Değişimi | Irreversible electroporation (IRE) is a minimally invasive, non-thermal, and cell-selective technique. When combined with the noninvasive nature of contact electrodes, they hold great promis… |
| Reversible | Skorupska et al · Biosens Bioelectron | 2025 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | We describe a novel lab-on-a-chip microsystem for cells electroporation, which can be used in studies comparing the effectiveness of two anti-cancer procedures. Our device in which we can si… |
| Reversible | Vélez · PLoS One | 2025 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | Using in-house computational tools, this work focuses on investigating how the combination of the electric field magnitude (E), bloodstream velocity (λinl) and pharmaco-kinetic profile (PK) … |
| İrreversible | Matkulcik et al · Int J Hyperthermia | 2025 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Background: Intraluminal irreversible electroporation (IRE) can be used for recanalizing occluded metal stents. However, optimal IRE parameters for consistent effects across different stent … |
| Reversible | Jacobs IV et al · Bioelectrochemistry | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Termal Etki ve Joule Isınması, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | The relationships between burst number, reversible, irreversible, and calcium electroporation have not been comprehensively evaluated in tumor tissue-mimics. Our findings indicate that elect… |
| Reversible | He · Gels | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | – | Silicone gel, used in the packaging of high-voltage, high-power semiconductor devices, generates bubbles during the packaging process, which accelerates the degradation of its insulation pro… |
| İrreversible | Fesmire et al · IEEE Trans Biomed Eng | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Objective: This study sought to investigate a novel strategy using temperature-controlled delivery of nanosecond pulsed electric fields as an alternative to the 50-100 microsecond pulses use… |
| İrreversible | González-Suárez et al · Biomed Eng Lett | 2024 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Purpose: Pulsed electrical field (PEF) ablation is an energy-based technique used to treat a range of cancers by irreversible electroporation (IRE). Our objective was to use computational an… |
| Reversible | Kumar et al · Micromachines (Basel) | 2023 | İn Siliko / Modelleme | Hesaplamalı Model | Transmembran Potansiyel Değişimi, Reversible Membran Permeabilizasyonu | This paper creates an approximate three-dimensional model for normal and cancerous cervical cells using image processing and computer-aided design (CAD) tools. The model is then exposed to l… |
| Reversible | Perera-Bel et al · IEEE Trans Biomed Eng | 2023 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Unlabelled: Tissue electroporation is the basis of several therapies. Electroporation is performed by briefly exposing tissues to high electric fields. It is generally accepted that electrop… |
| İrreversible | Lakshmi Narasimhan et al · Med Phys | 2023 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, İrreversible Por Oluşumu ve Hücre Ölümü | Background: Electroporation-based cancer treatments are minimally invasive, nonthermal interventional techniques that leverage cell permeabilization to ablate the target tumor. However, the … |
| Reversible | Vélez Salazar et al · Computers & Mathematics with Applications | 2022 | İn Siliko / Modelleme | Hesaplamalı Model | Sisplatin Hücre İçi Birikiminin Artması | Electroporation has become an important technique in cancer treatment to induce the drug internalization into cells by applying controlled electric pulses. In the present work, the simulatio… |
| İrreversible | Khorasani · Electromagn Biol Med | 2022 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | The primary purpose of cancer treatment with irreversible electroporation (IRE) is to maximize tumor damage and minimize surrounding healthy tissue damage. Finite element analysis is one of … |
| Reversible | Marino et al · Sci Rep | 2021 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Electroporation (EP), the increase of cell membrane permeability due to the application of electric pulses, is a universal phenomenon with a broad range of applications. In medicine, some of… |
| Reversible | Navickaite et al · Pharmaceutics | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | Electroporation-a transient electric-field-induced increase in cell membrane permeability-can be used to facilitate the delivery of anticancer drugs for antitumour electrochemotherapy. In re… |
| İrreversible | Hogenes et al · Sci Rep | 2020 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | The final ablation zone created with irreversible electroporation (IRE) depends on the size, shape and strength of the electric field that is influenced by several parameters. A profound und… |
| İrreversible | Gallinato et al · Phys Med Biol | 2019 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | The paper provides a numerical workflow, based on the 'real-life' clinical workflow of irreversible electroporation (IRE) performed for the treatment of deep-seated liver tumors. Thanks to a… |
| Reversible | Soba et al · Mathematics and Computers in Simulation | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrot Geometrisi ve Yerleşimi, Elektrik Alan Dağılımı ve Modellemesi | The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In this paper, an integrated analysis of the spatial distributions of th… |
| İrreversible | Zhao et al · IEEE Trans Biomed Eng | 2018 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | Unlabelled: For irreversible-electroporation (IRE)-based therapies, the underlying electric field distribution in the target tissue is influenced by the electroporation-induced conductivity … |
| İrreversible | Murovec et al · Biophys J | 2016 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Many approaches for studying the transmembrane potential (TMP) induced during the treatment of biological cells with pulsed electric fields have been reported. From the simple analytical mod… |
| Reversible | Bhonsle et al · Biomed Eng Online | 2015 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Elektrik Alan Dağılımı ve Modellemesi | Background: For electroporation-based therapies, accurate modeling of the electric field distribution within the target tissue is important for predicting the treatment volume. In response t… |
| İrreversible | Bonakdar et al · IEEE Trans Biomed Eng | 2015 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Doku İletkenliği ve Empedans Değişimi | Significance: Irreversible electroporation (IRE) is gaining popularity as a focal ablation modality for the treatment of unresectable tumors. One clinical limitation of IRE is the absence of… |
| İrreversible | Kurata et al · International Journal of Heat and Mass Transfer | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | Irreversible electroporation (IRE) is a novel method to ablate abnormal cells by applying a high voltage between the electrodes punctured in abnormal tissues. The cell membrane exposed to th… |
| İrreversible | Nickfarjam et al · Int J Hyperthermia | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | Purpose: Irreversible electroporation (IRE) is a new tumour ablation method used in cancer treatment procedures. In a successful IRE treatment it is crucial to impose minimum thermal damage … |
| İrreversible | Phillips · J Biomech Eng | 2014 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Reversible Membran Permeabilizasyonu | Nonthermal irreversible electroporation (NTIRE) is an ablation modality that utilizes microsecond electric fields to produce nanoscale defects in the cell membrane. This results in selective… |
| Reversible | Ritter et al · Biomed Tech (Berl) | 2013 | İn Siliko / Modelleme | Hesaplamalı Model | – | Article Fem-Driven Parameter Optimization of an Electrochemotherapy Catheter Prototype was published on September 7, 2013 in the journal Biomedical Engineering / Biomedizinische Technik (vol… |
| Reversible | Corovic et al · Biomed Eng Online | 2013 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | Background: Electroporation based therapies and treatments (e.g. electrochemotherapy, gene electrotransfer for gene therapy and DNA vaccination, tissue ablation with irreversible electropora… |
| İrreversible | Long · Technol Cancer Res Treat | 2013 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) has been shown to be an effective method of killing cells locally. In contrast to radiofrequency ablation, the mechanism by which cells are thought to die … |
| Reversible | Mahnič-Kalamiza et al · BMC Med Educ | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | Background: Electrochemotherapy is a local treatment that utilizes electric pulses in order to achieve local increase in cytotoxicity of some anticancer drugs. The success of this treatment … |
| Reversible | Golberg et al · Technol Cancer Res Treat | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Kas Kasılması ve Anestezi Gereksinimi, Elektrot Geometrisi ve Yerleşimi | The electric field threshold for muscle contraction is two orders of magnitudes lower than that for electroporation. Current electroporation treatment planning and electrode design studies f… |
| Reversible | Pavliha et al · Bioelectrochemistry | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi | Electrochemotherapy uses electroporation for enhancing chemotherapy. Electrochemotherapy can be performed using standard operating procedures with predefined electrode geometries, or using p… |
| Reversible | Zupanic et al · Phys Med Biol | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | In recent years, cancer electrochemotherapy (ECT), gene electrotransfer for gene therapy and DNA vaccination (GET) and tissue ablation with irreversible electroporation (IRE) have all entere… |
| İrreversible | Neal et al · IEEE Trans Biomed Eng | 2012 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | Irreversible electroporation is a new technique to kill cells in targeted tissue, such as tumors, through a nonthermal mechanism using electric pulses to irrecoverably disrupt the cell membr… |
| Reversible | Daniels et al · PLoS One | 2011 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | This study explores the hypothesis that combining the minimally invasive surgical techniques of cryosurgery and pulsed electric fields will eliminate some of the major disadvantages of these… |
| Reversible | Mahmood et al · Bioelectrochemistry | 2011 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrot Geometrisi ve Yerleşimi | Current technology has limited applicability for electroporation based treatment of deep-seated tumors, and is in general, not optimized in terms of compliance with clinically relevant param… |
| Reversible | Čorović et al · Med Biol Eng Comput | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Darbe Parametrelerinin Optimizasyonu | The aim of this study was to theoretically and experimentally investigate electroporation of mouse tibialis cranialis and to determine the reversible electroporation threshold values needed … |
| Reversible | Zupanic et al · Biomed Eng Online | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Gen Elektrotransferi (Plazmid DNA), Elektrik Alan Dağılımı ve Modellemesi | Background: Electroporation-based gene therapy and DNA vaccination are promising medical applications that depend on transfer of pDNA into target tissues with use of electric pulses. Gene el… |
| Reversible | Kos et al · J Membr Biol | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Doku İletkenliği ve Empedans Değişimi | Treatment of cutaneous and subcutaneous tumors with electrochemotherapy has become a regular clinical method, while treatment of deep-seated tumors is still at an early stage of development.… |
| Reversible | Miklavcic et al · Radiol Oncol | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Doku İletkenliği ve Empedans Değişimi, Darbe Parametrelerinin Optimizasyonu | Background: In order to reduce the side-effects of chemotherapy, combined chemotherapy-electroporation (electrochemotherapy) has been suggested. Electroporation, application of appropriate e… |
| İrreversible | Maor et al · J Biomech Eng | 2010 | İn Siliko / Modelleme | Hesaplamalı Model | Termal Etki ve Joule Isınması, Reversible Membran Permeabilizasyonu | Tissue ablation finds an increasing use in modern medicine. Nonthermal irreversible electroporation (NTIRE) is a biophysical phenomenon and an emerging novel tissue ablation modality, in whi… |
| Reversible | Lackovic et al · IEEE Trans. Dielect. Electr. Insul. | 2009 | İn Siliko / Modelleme | Hesaplamalı Model | Darbe Parametrelerinin Optimizasyonu, Elektrik Alan Dağılımı ve Modellemesi | Electrochemotherapy and electrogene therapy are new methods in molecular medicine based on electroporation-mediated introduction of foreign molecules (chemotherapeutic drugs, DNA) into targe… |
| Reversible | Granot et al · Int J Heat Mass Transf | 2008 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | Reversible electroporation is the temporary permeabilization of the cell membrane through the formation of nano-scale pores that are transient defects in the membrane. These pores are caused… |
| Reversible | Županič et al · Radiology and Oncology | 2008 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrot Geometrisi ve Yerleşimi, Elektrik Alan Dağılımı ve Modellemesi | Optimization of electrode position and electric pulse amplitude in electrochemotherapyBackground. In addition to the chemotherapeutic drug being present within the tumor during electric puls… |
| Reversible | Corovic et al · IEEE Trans. Plasma Sci. | 2008 | İn Siliko / Modelleme | Hesaplamalı Model | Elektrik Alan Dağılımı ve Modellemesi, Elektrot Geometrisi ve Yerleşimi | Electrochemotherapy (ECT) is an effective antitumor treatment employing locally applied high-voltage electric pulses in combination with chemotherapeutic drugs. For successful ECT, the entir… |
| Reversible | Sel et al · IEEE Trans Biomed Eng | 2007 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Darbe Parametrelerinin Optimizasyonu | In electrochemotherapy (ECT) electropermeabilization, parameters (pulse amplitude, electrode setup) need to be customized in order to expose the whole tumor to electric field intensities abo… |
| Reversible | Pavšelj et al · Ann Biomed Eng | 2007 | İn Siliko / Modelleme | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | As an alternative to viral methods that are controversial because of their safety issues, chemical and physical methods have been developed to enhance gene expression in tissues. Reversible … |
| İrreversible | Edd et al · Technol Cancer Res Treat | 2007 | İn Siliko / Modelleme | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | Irreversible Electroporation (IRE) is a new drug-free method to ablate undesirable tissue of particular use in cancer therapy. IRE achieves cell death within the targeted tissue through a se… |
| Reversible | Bougandoura et al · Bioelectricity | 2024 | Teknik / Cihaz Çalışması | – | Reversible Membran Permeabilizasyonu, Transmembran Potansiyel Değişimi | Cancer remains a global health challenge, necessitating effective treatments with fewer side effects. Traditional methods such as chemotherapy and surgery often have complications. Pulsed el… |
| Reversible | Lorenzo et al · IEEE Trans Biomed Eng | 2021 | Teknik / Cihaz Çalışması | – | Doku İletkenliği ve Empedans Değişimi, Termal Etki ve Joule Isınması | Objective: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue; this results in changes in electrical properties detectable … |
| Reversible | Ritter et al · Technol Cancer Res Treat | 2018 | Teknik / Cihaz Çalışması | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Irreversible electroporation and electrochemotherapy are 2 innovative electroporation-based minimally invasive therapies for the treatment of cancer. Combining nonthermal effects of irrevers… |
| İrreversible | van den Bos et al · J Vasc Interv Radiol | 2016 | Teknik / Cihaz Çalışması | – | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrot Geometrisi ve Yerleşimi | Purpose: Irreversible electroporation (IRE) uses high-voltage electric fields to achieve cell death. Although the mechanism of IRE is mainly designated as nonthermal, development of secondar… |
| Reversible | Tomov et al · Bioelectrochemistry | 2000 | Teknik / Cihaz Çalışması | – | Bleomisin Hücre İçi Birikiminin Artması, Gen Elektrotransferi (Plazmid DNA) | The electrodes used for electroporation, electrofusion, and electrotransfection, as well as in electrochemotherapy should not interact with the object and release electrolysis products. We s… |
| Reversible | Brandisky et al · Bioelectrochem Bioenerg | 1999 | Teknik / Cihaz Çalışması | – | Elektrot Geometrisi ve Yerleşimi | Electrochemotherapy is a method for cancer treatment consisting in combining intratumor injection of cytotoxic agent with the application of intensive electrical stimuli. Thus transient cell… |
| Reversible | Yang et al · Bioelectrochemistry | 2026 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu | The rigid cell wall of microalgae limits efficient intracellular protein extraction. Here, three pulsed electric field (PEF) energy distribution strategies-high-voltage few-pulse (HP), low-v… |
| İrreversible | Guo et al · Bioelectrochemistry | 2026 | Deneysel Biyofizik Çalışması | Deneysel Sistem | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | The traditional Hodgkin-Huxley (HH) model is mainly applicable to neuronal excitability under low electric fields but ails at high field intensities. In this study, an improved HH model inco… |
| Reversible | Rybak · Molecules | 2025 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu | This study evaluated the energy-dependent effects of pulsed electric field (PEF) treatment on the physicochemical properties, bioactive compounds, antioxidant activity, and microstructure of… |
| Reversible | Tamra et al · IEEE Trans Biomed Eng | 2022 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu, Bleomisin Hücre İçi Birikiminin Artması | This paper presents a 40 GHz microwave biosensor used to monitor and characterize single cells (THP-1) subjected to electrochemotherapy and obtain an electronic signature of the treatment ef… |
| İrreversible | López-Alonso · Sensors (Basel) | 2020 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Doku İletkenliği ve Empedans Değişimi, Reversible Membran Permeabilizasyonu | Classical application of electroporation is carried out by using fixed protocols that do not clearly assure the complete ablation of the desired tissue. Nowadays, new methods that pursue the… |
| Reversible | Feng · Microorganisms | 2019 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Transmembran Potansiyel Değişimi, Darbe Parametrelerinin Optimizasyonu | This article studies the sterilization effects of high-voltage pulsed electric field (PEF) of technology on filamentous fungi. A cell dielectric model was proposed based on the physical stru… |
| Reversible | Calin et al · Biomed Opt Express | 2017 | Deneysel Biyofizik Çalışması | Deneysel Sistem | Reversible Membran Permeabilizasyonu | Changes in optical and shape-related characteristics of B16F10 cells after electroporation were investigated using digital holographic microscopy (DHM). Bipolar rectangular pulses specific f… |
| İrreversible | Davalos et al · International Journal of Heat and Mass Transfer | 2008 | Deneysel Biyofizik Çalışması | Deneysel Sistem | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Certain electrical fields, when applied across a cell membrane, can have the sole effect of membrane permeabilization, which is referred to as electroporation. When the permeabilization is ir… |
| Reversible | Rózsa et al · – | 2025 | Ön Baskı | – | – | Background The rising prevalence of cutaneous and subcutaneous tumors has driven interest in electrochemotherapy (ECT) as a potential treatment. However, patient-reported outcomes remain und… |
| Reversible | Yadav et al · – | 2025 | Ön Baskı | Hücre Kültürü | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | Current electrode technologies are too rigid for safe and effective delivery of electrotherapy in the brain, and patients with glioblastoma continue to face a devastating prognosis, with med… |
| Reversible | Ušaj et al · – | 2024 | Ön Baskı | Hayvan (İn Vivo) | Gen Elektrotransferi (Plazmid DNA), Darbe Parametrelerinin Optimizasyonu | In the search for safe induction of cellular and humoral cancer immunity dendritic cell-based therapies hold great potential. This approach is based on manipulation of dendritic cells to act… |
| Reversible | Fülöp et al · – | 2023 | Ön Baskı | Hesaplamalı Model | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | Electrophoresis facilitated cancer treatment has demonstrated experimental efficacy in enhancing drug delivery within vascularised tumours. However, the lack of realistic mathematical models… |
| Reversible | Lisec et al · – | 2023 | Ön Baskı | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Darbe Parametrelerinin Optimizasyonu | Background The vascular endothelium consists of endothelial cells (ECs) with important biological functions, and their impairment is associated with various pathologies. ECs vary based on ti… |
| İrreversible | Wang et al · – | 2020 | Ön Baskı | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | BackgroundTo evaluate the clinical efficacy and safety of ablating renal cell carcinoma (RCC) by irreversible electroporation (IRE). MethodsFifteen patients (19 lesions) with RCC who underwe… |
| İrreversible | Jordan-Diaz et al · 2026 Global Medical Engineering Physics Exchanges/ Pan American Health Care Exchanges (GMEPE/PAHCE) | 2026 | Kongre Özeti | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Elektrik Alan Dağılımı ve Modellemesi | Irreversible electroporation (IRE) is a non-thermal ablation technique used for the treatment of soft tissue tumors when thermal ablation is not feasible. Treatment outcome depends on tissue… |
| Reversible | Malysko et al · 2021 13th International Conference on Measurement | 2021 | Kongre Özeti | Hesaplamalı Model | Reversible Membran Permeabilizasyonu, Elektrik Alan Dağılımı ve Modellemesi | Electroporation is a highly effective method in various fields of application, including cancer treatment, where when combined with drugs (called electrochemotherapy), it improves treatment … |
| İrreversible | Yang et al · Volume 3: Biomedical and Biotechnology Engineering | 2017 | Kongre Özeti | Hesaplamalı Model | İrreversible Por Oluşumu ve Hücre Ölümü, Termal Etki ve Joule Isınması | The aim of this study was to analyze five factors that are responsible for the ablation volume and maximum temperature during the procedure of irreversible electroporation (IRE). The five fa… |
| İrreversible | Rouientan et al · J Vasc Interv Radiol | 2026 | Editöryal / Mektup | – | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | for Consistent Pulsed Electric Field Terminology in IR Literature From: Hamidreza Rouientan, MD Mohammad Ghasemi-Rad, MD Shahram Akhlaghpoor, MD Department of Interventional Radiology (H.R.,… |
| Reversible | Kulbacka et al · Expert Opin Drug Deliv | 2025 | Editöryal / Mektup | – | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu | 1. Drug resistance or even multidrug resistance (MDR) in cancer is still one of the greatest challenges in oncological therapy today. Many cancers develop mechanisms to evade conventional tr… |
| İrreversible | Tewari et al · Cardiovasc Intervent Radiol | 2025 | Editöryal / Mektup | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | s: Early Signals, Clinical Relevance and Risk, and a Call for Comparative Data Sanjit O. Tewari1 • Ethan B. Ludmir2 • Bruno C. Odisio3 Published online: 18 December 2025 Ó Springer Science+B… |
| Reversible | Rembiałkowska et al · Pharmaceuticals (Basel) | 2024 | Editöryal / Mektup | – | – | This Special Issue is dedicated to the memory of Professor Jolanta Saczko (1964-2023), a remarkable leader whose guidance and dedication were instrumental in advancing electroporation-based … |
| Reversible | De Robertis et al · Vaccines (Basel) | 2023 | Editöryal / Mektup | – | – | Immunotherapy can now be regarded as an attractive approach for cancer and infectious disease treatments [...]. |
| Reversible | Heller et al · Technol Cancer Res Treat | 2019 | Editöryal / Mektup | İnsan | Darbe Parametrelerinin Optimizasyonu | Electroporation Based Therapies - Editorial Special Collection on ElectroporationBased Therapies: A Selection of Papers From the Second World Congress on Electroporation Technology in Cancer… |
| Reversible | Miklavcic et al · Biomed Eng Online | 2015 | Editöryal / Mektup | İnsan | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | When a cell is exposed to a sufficiently intense electric field (for a sufficient duration), local defects in the cell membrane appear and become permeable to molecules that otherwise cannot… |
| İrreversible | Heger et al · Hepatobiliary Pancreat Dis Int | 2015 | Editöryal / Mektup | Hayvan (İn Vivo) | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a CE- and FDAapproved treatment modality for pancreatic and liver tumors that is based on the site-confined destruction of tumor tissue by multiple shor… |
| Reversible | Quaglino et al · Pigment Cell Melanoma Res | 2011 | Editöryal / Mektup | İnsan | – | , Electrochemotherapy (ECT) represents a new therapeutic option for primary and metastatic skin tumours (Mir et al., 2006). In recent years, many studies have shown its clinical efficacy in … |
| Reversible | Vizintin et al · Radiol Oncol | 2023 | Düzeltme / Erratum | – | Sisplatin Hücre İçi Birikiminin Artması | In Figure 3A, three horizontal bars representing the standard deviation were incorrectly drawn.The corrected figure is shown below. |
| İrreversible | Yaxley · Investig Clin Urol | 2022 | Düzeltme / Erratum | – | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | This corrects the article on p. 285 in vol. 63, PMID: 35534217. |
| Reversible | Anon · Future Oncol | 2015 | Düzeltme / Erratum | – | – | rapy’, which appeared in the December 2014 issue of Future Oncology (Future Oncol. 10[15], 2429–2434 [2014]), it has been brought to our attention that the author names were presented incorr… |
| Reversible | Hansen et al · PLoS One | 2015 | Düzeltme / Erratum | Hücre Kültürü | Kalsiyum Elektroporasyonu ve ATP Tükenmesi, Elektrik Alan Dağılımı ve Modellemesi | th following Calcium Electroporation, Relative Effect of Calcium Concentration and Electric Field Strength Emilie Louise Hansen, Esin Bengisu Sozer, Stefania Romeo, Stine Krog Frandsen, P. T… |
| Reversible | Hu et al · Research (Wash D C) | 2026 | Belirtilmemiş | – | Sitotoksik İlaç Geçirgenliğinin Potansiyalizasyonu, Gen Elektrotransferi (Plazmid DNA) | Bioelectronic patches have emerged as promising tools for localized and precise intracellular delivery. However, their application is limited by poor conformability and suboptimal delivery e… |
| İrreversible | Faiella et al · Diagn Interv Radiol | 2026 | Belirtilmemiş | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) is a non-thermal ablative technique that preserves vessels and nerves, making it suitable for tumors in anatomically complex regions. We report the technic… |
| Reversible | Dermesonlouoglou · Foods | 2025 | Belirtilmemiş | – | – | The aim of this research was to study the effect of osmotic dehydration (OD) and/or pulsed electric field (PEF) on the quality of MAP-packed potatoes, both as raw materials and after deep fr… |
| İrreversible | He et al · BMJ Open | 2025 | Protokol | İnsan | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: Transurethral resection of the prostate (TURP) is the gold standard surgical treatment to lower urinary tract symptoms and benign prostatic obstruction (LUTS/BPO). Although it … |
| İrreversible | Xu et al · J. Innov. Opt. Health Sci. | 2025 | Belirtilmemiş | – | Elektrot Geometrisi ve Yerleşimi | Electroacoustic Tomography (EAT) is an imaging technique that detects ultrasound waves induced by electrical pulses, offering a solution for real-time electroporation monitoring. This study … |
| Reversible | Johnson · – | 2024 | Belirtilmemiş | – | İrreversible Por Oluşumu ve Hücre Ölümü, Kalsiyum Elektroporasyonu ve ATP Tükenmesi | This paper explores the innovative approach of cardiac calcium electroporation as a potential advancement in catheter ablation techniques, building upon the historical context of thermal abl… |
| Reversible | Ma · Molecules | 2023 | Belirtilmemiş | – | – | A combination of the peroxymonosulfate (PMS) electro-activation process and the electro-oxidation process driven by a pulsed electric field (PEF) was used to degrade sulfadiazine (SND) waste… |
| İrreversible | He et al · Front Oncol | 2021 | Protokol | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Introduction: The classical pathway for the therapy of low- to intermediate-risk localized prostate cancer is radical prostatectomy or radiation therapy, which has shown a high incidence of … |
| Reversible | Nathamgari et al · Small | 2020 | Belirtilmemiş | – | – | Introducing exogenous molecules into cells with high efficiency and dosage control is a crucial step in basic research as well as clinical applications. Here, the capability of the nanofount… |
| İrreversible | Yao · PLoS One | 2017 | Belirtilmemiş | – | İrreversible Por Oluşumu ve Hücre Ölümü, Reversible Membran Permeabilizasyonu | Irreversible electroporation (IRE) produced by a pulsed electric field can ablate tissue. In this study, we achieved an enhancement in ablation area by using a combination of short high-volt… |
| İrreversible | Hjouj et al · J Membr Biol | 2010 | Belirtilmemiş | – | Reversible Membran Permeabilizasyonu, İrreversible Por Oluşumu ve Hücre Ölümü | We introduce and characterize the use of MRI for studying nonthermal irreversible electroporation (NTIRE) in a vegetative tissue model. NTIRE is a new minimally invasive surgical technique f… |
| Reversible | Sersa et al · Curr Oncol | 2009 | Belirtilmemiş | – | – | Several novel tumour-targeting and drug-delivery approaches in cancer treatment are currently undergoing intensive investigation, among them physical approaches such as tissue electroporatio… |
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