Ovarian Tumours
Urogynaecological Tumours
Electroporation in ovarian tumours has been studied largely through peritoneal spread and preclinical models; the number of clinical series is limited.
15total publications
0clinical studies
14preclinical studies
0reviews
2009–2026publication span
Evidence Status by Regime
Reversible electroporation (RE-ECT)
11publications
0clinical
10preclinical
Preclinical Evidence
2009–2026 · Under Clinical Investigation
Irreversible electroporation (IRE-ECT)
4publications
0clinical
4preclinical
Exploratory Evidence
2015–2026 · Early Research Stage
Mechanisms Reported in This Area
Terms were detected by automatic matching over publication abstracts; the figure gives the number of publications containing the term.
Reversible Membrane Permeabilisation 7
Increased Intracellular Cisplatin Accumulation 6
Optimisation of Pulse Parameters 5
Irreversible Pore Formation and Cell Death 4
Apoptosis Induction 3
Potentiation of Cytotoxic Drug Permeability 3
Muscle Contraction and Anaesthesia Requirement 2
Nanosecond Pulsed Electric Field (nsPEF) 2
Gene Electrotransfer (Plasmid DNA) 2
Disruption of Calcium Homeostasis 1
Increased Intracellular Bleomycin Accumulation 1
Tissue Conductivity and Impedance Change 1
Study Type Distribution
Bar length is scaled to the most common study type; the percentage gives the share of the whole area. Colour marks the evidence tier of the study type, the same scale as the evidence map.
| Study type | Publications | Share within this area |
|---|---|---|
| Animal Study | 9 | 60% |
| In Vitro Study | 4 | 27% |
| In Silico / Modelling | 1 | 7% |
| Preprint | 1 | 7% |
Literature Evidence Table
15 publications listed in order of evidence strength. Click a title to open the citation, mechanism and full abstract drawer.
| Regime | Publication | Year | Study type | Model | Mechanism | Abstract |
|---|---|---|---|---|---|---|
| Irreversible | Bose · Indian J Gynecol Oncolog | 2026 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Purpose This review synthesizes current research from Irreversible electroporation in Ovarian Cancer regarding the expanding roles of electroporation in ovarian cancer. It addresses how cont… |
| Reversible | Scuderi et al · Radiol Oncol | 2024 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Gene Electrotransfer (Plasmid DNA) | Background: Electrochemotherapy (ECT) is a treatment involving the administration of chemotherapeutics drugs followed by the application of 8 square monopolar pulses of 100 μs duration at a … |
| Reversible | Łapińska et al · Biomed Pharmacother | 2024 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Calcium Electroporation and ATP Depletion | Calcium electroporation (CaEP) is an efficient approach for ovarian cancer treatment. It causes cell death by introducing elevated levels of calcium into cells. In this work, the research fo… |
| Reversible | Paffenholz et al · Proc Natl Acad Sci U S A | 2022 | Animal Study | Animal (In Vivo) | – | High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to the limited effectiveness of existing chemo- and immunotherapies. To elucidate mechanisms mediating sensi… |
| Irreversible | Polajzer et al · Radiol Oncol | 2020 | Animal Study | Animal (In Vivo) | Immunogenic Cell Death (ICD), Irreversible Pore Formation and Cell Death | Background Tumor cells can die via immunogenic cell death pathway, in which damage-associated molecular pattern molecules (DAMPs) are released from the cells. These molecules activate cells … |
| Reversible | Ruzgys et al · Sci Rep | 2018 | Animal Study | Animal (In Vivo) | Gene Electrotransfer (Plasmid DNA), Optimisation of Pulse Parameters | Current electrotransfection protocols are well-established for decades and, as a rule, employ long micro-millisecond range electric field pulses to facilitate DNA transfer while application … |
| Irreversible | Rolong et al · Integr Biol (Camb) | 2017 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | We explored the use of irreversible electroporation (IRE) and high-frequency irreversible electroporation (H-FIRE) to induce cell death of tumor-initiating cells using a mouse ovarian surfac… |
| Reversible | Ibey et al · Biochem Biophys Res Commun | 2014 | Animal Study | Animal (In Vivo) | Nanosecond Pulsed Electric Field (nsPEF), Reversible Membrane Permeabilisation | Multiple studies have shown that bipolar (BP) electric pulses in the microsecond range are more effective at permeabilizing cells while maintaining similar cell survival rates as compared to… |
| Reversible | Yang et al · J Exp Clin Cancer Res | 2009 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Apoptosis Induction | Background: Patients received electrochemotherapy often associated with unpleasant sensations mainly result from low-frequency electric pulse induced muscle contractions. Increasing the repe… |
| Reversible | Łapińska et al · Pharmaceutics | 2020 | In Vitro Study | Cell Culture | Increased Intracellular Cisplatin Accumulation, Apoptosis Induction | Estrogens (Es) play a significant role in the carcinogenesis and progression of ovarian malignancies. Depending on the concentration, Es may have a protective or toxic effect on cells. Moreo… |
| Reversible | Salimi et al · Biomicrofluidics | 2017 | In Vitro Study | Cell Culture | Tissue Conductivity and Impedance Change, Electric Field Distribution and Modelling | Applying sufficiently strong pulsed electric fields to a cell can permeabilize the membrane and subsequently affect its dielectric properties. In this study, we employ a microfluidic dielect… |
| Reversible | Saczko et al · Neoplasma | 2016 | In Vitro Study | Cell Culture | Increased Intracellular Bleomycin Accumulation | The presented study aimed to evaluate in vitro the effectiveness of improvement standard chemotherapy with bleomycin by electroporation in two various ovarian cancer cell lines. Two human ov… |
| Reversible | Saczko et al · Biomed Pharmacother | 2014 | In Vitro Study | Cell Culture | Increased Intracellular Cisplatin Accumulation, Reversible Membrane Permeabilisation | High electric field, applied to plasma membrane, affects organization of the lipid molecules, generating transient hydrophilic electropores. The application of the cell membrane electroporat… |
| Irreversible | Dermol et al · J Membr Biol | 2015 | In Silico / Modelling | Computational Model | Irreversible Pore Formation and Cell Death, Electrode Geometry and Placement | Electroporation is a phenomenon used in the treatment of tumors by electrochemotherapy, non-thermal ablation with irreversible electroporation, and gene therapy. When treating patients, eith… |
| Reversible | Marverti et al · – | 2026 | Preprint | Cell Culture | Increased Intracellular Cisplatin Accumulation, Potentiation of Cytotoxic Drug Permeability | Ovarian and colorectal cancers have the highest incidence and mortality in the world, after breast cancer. Despite the initial response to Pt-drugs or 5-fluorouracil (5-FU), many cancer cell… |
Limitations
The counts on this page are bounded by the scope of the source PDF archive and are not a systematic review of the area's literature. Study type and mechanism labels are derived automatically; for critical decisions consult the full texts of the publications listed. The evidence level reflects the number of publications, not their methodological quality.