Non-Oncological IRE Applications
Non-Oncological Applications
This heading gathers records in which irreversible electroporation is investigated on non-tumour targets: ablation of vascular smooth muscle cells, tissue decellularisation, preparation of a tissue niche for cell transplantation, limiting scar formation and nerve microsurgery. All records are animal studies and none constitutes a clinical indication; the area is kept in the corpus to show where the same biophysical mechanism is being tested outside oncology, and it does not appear in the indication landscape.
Evidence Status by Regime
Irreversible electroporation (IRE-ECT)
Preclinical Evidence
2007–2026 · Under Clinical Investigation
Mechanisms Reported in This Area
Terms were detected by automatic matching over publication abstracts; the figure gives the number of publications containing the term.
Study Type Distribution
Bar length is scaled to the most common study type; the percentage gives the share of the whole area. Colour marks the evidence tier of the study type, the same scale as the evidence map.
| Study type | Publications | Share within this area |
|---|---|---|
| Animal Study | 10 | 100% |
Literature Evidence Table
10 publications listed in order of evidence strength. Click a title to open the citation, mechanism and full abstract drawer.
| Regime | Publication | Year | Study type | Model | Mechanism | Abstract |
|---|---|---|---|---|---|---|
| Irreversible | Xu et al · Front Cell Dev Biol | 2026 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Apoptosis Induction | Introduction: Minimally invasive treatments for lower extremity varicose veins carry risks of thermal diffusion injury, nerve damage, ectopic embolism, and limited efficacy, highlighting the… |
| Irreversible | Han et al · J Surg Res | 2024 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Introduction: Irreversible electroporation (IRE) is a tissue ablation technology that kills cells with short electrical pulses that do not induce thermal damage, thereby preserving the extra… |
| Irreversible | Zhang et al · Radiol Oncol | 2023 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Background: Pancreatic islet transplantation via infusion through the portal vein, has become an established clinical treatment for patients with type 1 diabetes. Because the engraftment eff… |
| Irreversible | Pelaez et al · Ann Biomed Eng | 2020 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Irreversible electroporation (IRE) is an emerging technology for non-thermal ablation of solid tumors. This study sought to integrate electrodes into microporous poly(caprolactone) (PCL) sca… |
| Irreversible | Chang et al · Biotechniques | 2017 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | The critical shortage of donor organs has spurred investigation of alternative approaches to either generate replacement organs or implant exogenous cells for treatment of end-stage organ fa… |
| Irreversible | Golberg et al · J Invest Dermatol | 2016 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Preventing the formation of hypertrophic scars, especially those that are a result of major trauma or burns, would have enormous impact in the fields of regenerative and trauma medicine. In … |
| Irreversible | Maor et al · J Vasc Interv Radiol | 2010 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Purpose: To evaluate the effect of endovascular nonthermal irreversible electroporation (NTIRE) on blood vessels. Materials and methods: Specially made endovascular devices with four electro… |
| Irreversible | Phillips et al · J Biomech Eng | 2010 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Tissue scaffolding is a key component for tissue engineering, and the extracellular matrix (ECM) is nature's ideal scaffold material. A conceptually different method is reported here for pro… |
| Irreversible | Maor et al · PLoS One | 2009 | Animal Study | Animal (In Vivo) | Optimisation of Pulse Parameters, Irreversible Pore Formation and Cell Death | Background: Non thermal Irreversible electroporation (NTIRE) is a new tissue ablation method that induces selective damage only to the cell membrane while sparing all other tissue components… |
| Irreversible | Chang et al · Neurosurgery | 2007 | Animal Study | Animal (In Vivo) | – | Objective: Microfabricated devices with nanoscale features have been proposed as new microinstrumentation for cellular and subcellular surgical procedures, but their effectiveness in vivo ha… |
Limitations
The counts on this page are bounded by the scope of the source PDF archive and are not a systematic review of the area's literature. Study type and mechanism labels are derived automatically; for critical decisions consult the full texts of the publications listed. The evidence level reflects the number of publications, not their methodological quality.