Lung & Peribronchial Tumours
Deep Organ Tumours
Lung and peribronchial sites are technically demanding because of the electrical conductivity of air-filled tissue and respiratory motion. The number of publications in the corpus is limited and the area is largely at an early research stage.
17total publications
2clinical studies
8preclinical studies
3reviews
2002–2026publication span
Evidence Status by Regime
Reversible electroporation (RE-ECT)
6publications
1clinical
1preclinical
Exploratory Evidence
2002–2025 · Early Research Stage
Irreversible electroporation (IRE-ECT)
11publications
1clinical
7preclinical
Preclinical Evidence
2012–2026 · Under Clinical Investigation
Mechanisms Reported in This Area
Terms were detected by automatic matching over publication abstracts; the figure gives the number of publications containing the term.
Irreversible Pore Formation and Cell Death 12
Reversible Membrane Permeabilisation 12
Necrosis and Necroptosis 4
Increased Intracellular Bleomycin Accumulation 3
Optimisation of Pulse Parameters 3
Apoptosis Induction 3
Increased Intracellular Cisplatin Accumulation 2
Mitochondrial Dysfunction and Oxidative Stress 2
Systemic / Abscopal Immune Response 1
Preservation of Extracellular Matrix and Tissue Scaffold 1
Electric Field Distribution and Modelling 1
Electrode Geometry and Placement 1
Study Type Distribution
Bar length is scaled to the most common study type; the percentage gives the share of the whole area. Colour marks the evidence tier of the study type, the same scale as the evidence map.
| Study type | Publications | Share within this area |
|---|---|---|
| Randomized Clinical Trial | 1 | 6% |
| Clinical Study | 1 | 6% |
| Case Report | 3 | 18% |
| Review | 3 | 18% |
| Animal Study | 7 | 41% |
| In Vitro Study | 1 | 6% |
| Not reported | 1 | 6% |
Literature Evidence Table
17 publications listed in order of evidence strength. Click a title to open the citation, mechanism and full abstract drawer.
| Regime | Publication | Year | Study type | Model | Mechanism | Abstract |
|---|---|---|---|---|---|---|
| Reversible | Egeland et al · MRAJ | 2023 | Randomized Clinical Trial | Human | – | Background: In this randomized clinical trial, we compared endoscopic-assisted electrochemotherapy (ECT) with argon plasma coagulation (APC) in patients suffering from esophageal cancer. We … |
| Irreversible | Solomon SB · – | 2016 | Clinical Study | Human | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | ses to the Lung PROTOCOL FACE PAGE FOR MSKCC THERAPEUTIC/DIAGNOSTIC PROTOCOL Principal Investigator/Department: Stephen Solomon, MD Co-Principal Investigator(s)/Department: Nancy Kemeny, MD … |
| Reversible | McMorrow et al · Br J Oral Maxillofac Surg | 2017 | Case Report | Human | Increased Intracellular Bleomycin Accumulation | Venous malformations are congenital anomalies of the vascular system. The injection of bleomycin (a cytotoxic, antitumour drug) into the lesion is a safe and effective treatment for low-flow… |
| Irreversible | Niessen et al · Rofo | 2012 | Case Report | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Einführung In den letzten Jahren haben minimalinvasive Behandlungstechniken deutlich an Bedeutung gewonnen, insbesondere wenn chirurgische Interventionen nicht als Behandlungsalternative inf… |
| Irreversible | Usman et al · Med Sci Monit | 2012 | Case Report | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: Percutaneous irreversible electroporation (IRE) of lung tumors is a new minimally invasive technique which has recently been used in the treatment of soft tissue tumors. Case rep… |
| Irreversible | Lassandro · Pol J Radiol | 2023 | Review | Literature Analysis | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | Thermal ablation is a minimally invasive technology used to treat many types of tumors, including lung cancer. Specifically, lung ablation has been increasingly performed for unsurgical fit … |
| Reversible | Arbeitskreis für fokale und Mikrotherapie der Akademie der Deutschen Gesellschaft für Urologie e.V. et al · Urologe A | 2015 | Review | Human | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: Irreversible electroporation (IRE), a new tissue ablation procedure available since 2007, could meet the requirements for ideal focal therapy (FT) with its postulated features, e… |
| Reversible | Jahangeer et al · Cancer Treat Rev | 2013 | Review | Human | – | Lung cancer remains the most common cancer diagnosed worldwide and has one of the lowest survival rates of all cancers. Surgery remains the only curative treatment option but because most pa… |
| Irreversible | Kim · PLoS One | 2026 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Mitochondrial Dysfunction and Oxidative Stress | This study aimed to optimize irreversible electroporation (IRE) parameters to enhance intracellular injury, specifically targeting nuclear and mitochondrial structures that are insufficientl… |
| Irreversible | Zhang et al · Transl Res | 2026 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Objective: To assess the feasibility and safety of bronchoscopy-guided synergistic pulsed irreversible electroporation (S-IRE) for ablating pulmonary tissues. Methods: Three Bama pigs underw… |
| Irreversible | Hay · Biomedicines | 2024 | Animal Study | Animal (In Vivo) | Reversible Membrane Permeabilisation, Irreversible Pore Formation and Cell Death | In this study, the feasibility of treating canine primary lung tumors with high-frequency irreversible electroporation (H-FIRE) was investigated as a novel lung cancer treatment option. H-FI… |
| Irreversible | Fujimori et al · Bioelectricity | 2021 | Animal Study | Animal (In Vivo) | Irreversible Pore Formation and Cell Death, Reversible Membrane Permeabilisation | Background: This study investigated the sparing of the extracellular matrix (ECM) and blood vessels at the site of lung irreversible electroporation (IRE), and its impact on postablation T c… |
| Irreversible | Kodama et al · J Thorac Cardiovasc Surg | 2018 | Animal Study | Animal (In Vivo) | Increased Intracellular Cisplatin Accumulation, Reversible Membrane Permeabilisation | Objective: To evaluate the feasibility of catheter-based endobronchial electroporation for the treatment of peribronchial tumors and assess the incidence of treatment-related adverse events.… |
| Irreversible | Song · World J Surg Oncol | 2018 | Animal Study | Animal (In Vivo) | Apoptosis Induction, Reversible Membrane Permeabilisation | Background: Steep pulse therapy can irreversible electrically brackdown of tumor membrance and cause cell death. In previous studies, we investigated the effect of steep pulsed electroporati… |
| Reversible | Salomskaite-Davalgiene et al · Medicina (Kaunas) | 2002 | Animal Study | Animal (In Vivo) | Increased Intracellular Bleomycin Accumulation, Necrosis and Necroptosis | Under the influence of strong electric fields the permeability of tumor cell membranes to poor permeating drugs increases and as a result the tumor growth is inhibited. This new tumor treatm… |
| Irreversible | Song et al · Int J Clin Exp Med | 2014 | In Vitro Study | Cell Culture | Apoptosis Induction, Reversible Membrane Permeabilisation | To explore the mechanisms for steep pulse irreversible electroporation technology to kill the lung cancer cell L9981. The apoptosis, cells mitochondrial membrane potential, internal PH chang… |
| Reversible | Radzevičiūtė-Valčiukė et al · Pharmaceutics | 2025 | Not reported | – | Increased Intracellular Bleomycin Accumulation, Increased Intracellular Cisplatin Accumulation | Background/Objectives: Electrochemotherapy (ECT) is a reliable and potent technique for managing primary tumors; however, significant efforts are being made to characterize and improve the s… |
Limitations
The counts on this page are bounded by the scope of the source PDF archive and are not a systematic review of the area's literature. Study type and mechanism labels are derived automatically; for critical decisions consult the full texts of the publications listed. The evidence level reflects the number of publications, not their methodological quality.