{ "_sema": { "aciklama": "Otomatik doğrulama kütüğü. Bu portalde insan incelemesi yoktur; her karar sürümlenmiş bir otomatik hattan çıkar ve girdileri depoda olduğu için tekrar üretilebilir.", "anahtar": "Kayıt kimliği (references.json içindeki id). Korpusa girmeyen kayıtlar 'yayimlanmayan-' önekiyle ve kaydın alan özetiyle anılır.", "durumlar": { "auto_confirmed": "En az iki doğrulama sinyali sınıflandırmayı doğruladı.", "auto_corrected": "Süreç sınıflandırmayı değiştirdi ve düzeltilmiş kayıt ikinci kez doğrulandı.", "conflict": "Doğrulama sinyalleri birbiriyle çelişiyor.", "excluded_from_corpus": "Yayın elektroporasyon literatürüne ait değil; yayımlanan referans listesinden çıkarılır.", "insufficient": "Karar için yeterli metin ya da indeks verisi yok.", "legacy_unverified": "Eski düzeltme kütüğünden taşındı, güncel hattan geçmedi; hiçbir sayımı etkilemez.", "quarantined_from_scoring": "Korpusa aittir ama incelenen girişim elektroporasyon değildir; sayıma girmez." }, "gerekceKaynagi": { "archived_model_output": "Metin anlamsal sınıflandırıcının arşivlenmiş ham çıktısıdır ve olduğu gibi yayımlanır; decisionsHash o dosyaların baytlarından hesaplandığı için düzeltilmez.", "pipeline": "Metni doğrulama süreci üretti." }, "girdiler": { "dizin": "_work/dogrulama/dizin.json", "hamKararlar": "_work/dogrulama/kararlar/", "istem": "_work/dogrulama/siniflandirici-istemi.md" }, "kapi": "Bir kayıt literatür olgunluğu hesabına ancak countsTowardMaturity true ise girer. Bunun için BÜTÜN şu koşullar sağlanmalıdır: durum auto_confirmed ya da auto_corrected; incelenen girişim elektroporasyon; primaryRelevance, modalityMatch, studyDesignMatch ve diseaseAreaMatch sinyallerinin hepsi 'pass' (diseaseAreaMatch yalnızca genel-prensipler alanında aranmaz, çünkü orada bir hastalık alanı iddiası yoktur); belge türü sonuç bildiren bir tür (Makale, Ön Baskı, Kongre Özeti, Tez) ve başlığı yazıyı protokol ya da çalışma önerisi olarak duyurmuyor; hiçbir kaynakta 'fail' yok. Üst kademeyi açan güçlü yayın ayrıca tierEligible=true olmalıdır: yukarıdakilere ek olarak künyesi dış bir dizinde doğrulanmış (bibliographicMatch='pass') olmalıdır. conflict, insufficient, quarantined_from_scoring ve legacy_unverified kayıtlar kütüphanede görünür, hiçbir eşiği ve rozeti etkilemez.", "mutabakat": "Her boyutta karar için en az İKİ doğrulama sinyali aynı sonucu vermelidir. Tek sinyal yalnızca 'unknown' üretir. Sinyallerin ayrı kararları signalSources altında yazılır. Sinyaller bağımsız KAYNAK değildir: kural motoru ile anlamsal sınıflandırıcı aynı metni okur, dış dizin ve MeSH ise ayrı bir kaynaktır.", "sinyalKaynaklari": { "_not": "s2 ve s3 bağımsız kaynak DEĞİLDİR: ikisi de aynı metni okur, iki ayrı yöntemdir. Bağımsız olan s1 kaynaklarıdır. Sınıflandırma boyutlarının hepsinde en az bir s1 sinyali yer alır; yani hiçbir karar yalnızca portalın kendi okumasına dayanmaz.", "s1_index": "Dış kaynak: dizin kaydının kendi yayın tipi alanı.", "s1_mesh": "Dış kaynak: dizin kaydının MeSH terimleri.", "s2_rules": "Kaydın kendi metni üzerinde çalışan kural motoru.", "s3_semantic": "Kaydın AYNI metni üzerinde çalışan anlamsal sınıflandırıcı." }, "sinyaller": [ "identifierPresent", "bibliographicMatch", "primaryRelevance", "modalityMatch", "diseaseAreaMatch", "documentTypeMatch", "studyDesignMatch" ] }, "kayitlar": { "ref-00702109da00": { "correctionApplied": { "documentType": "Protokol" }, "countsTowardMaturity": false, "decisionCode": "363939b8ae770ff0", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "Özet baştan sona gelecek zamanla yazılmış bir çalışma protokolü: '70 patients that will be developed in two stages', '28 patients will be enrolled', 'the second stage of the trial will be performed'; sonuç verisi yok ve PubMed yalnızca 'Journal Article' etiketlemiş. Faz II randomize tasarım korunur, değişen yalnızca belge türüdür.", "rationaleSource": "archived_model_output", "reasonCodes": [ "document_type_not_outcome_reporting", "correction_revalidated" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=0.909", "karar": "pass" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "kolon-ve-rektum-kanseri", "karar": "pass" }, "s3_semantic": { "kanit": "kolon-ve-rektum-kanseri", "karar": "pass" } }, "documentTypeMatch": { "s2_rules": { "kanit": "Protokol", "karar": "pass" }, "s3_semantic": { "kanit": "Protokol", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT", "karar": "pass" }, "s3_semantic": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s2_rules": { "kanit": "Randomize Klinik Çalışma", "karar": "pass" }, "s3_semantic": { "kanit": "Randomize Klinik Çalışma", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "pass", "documentTypeMatch": "pass", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "pass" }, "sourceHash": "72cb0bec17e4", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "auto_corrected", "validatorCodeHash": "501a37100441" }, "ref-007e0a026813": { "correctionApplied": {}, "countsTowardMaturity": true, "decisionCode": "83eacb2ac9587cba", "decisionsHash": "a286e3051043", "interventionRole": 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"karar": "unknown" } }, "studyDesignMatch": { "s1_mesh": { "kanit": "Klinik Çalışma", "karar": "pass" }, "s2_rules": { "kanit": "Vaka Serisi", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "pass", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "pass" }, "sourceHash": "ad6bb4f1e1c1", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": true, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "auto_confirmed", "validatorCodeHash": "501a37100441" }, "ref-008af9db2f89": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "cdc967ba7d446d91", "decisionsHash": "a286e3051043", "interventionRole": "arka_plan", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "'In a clinical trial (NCT03714178), paroxysmal atrial fibrillation patients underwent PVI'; PubMed 'Clinical Trial'.", "rationaleSource": "archived_model_output", "reasonCodes": [ "primary_relevance_signals_split", "document_type_single_signal_only" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "kardiyak-pfa", "karar": "pass" }, "s2_rules": { "kanit": "kardiyak-pfa", "karar": "pass" }, "s3_semantic": { "kanit": "kardiyak-pfa", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "IRE", "karar": "pass" }, "s3_semantic": { "kanit": "IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": 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}, "s2_rules": { "kanit": "elektroporasyon başlıkta gelecek önerisi rolünde", "karar": "fail", "rol": "gelecek_onerisi" }, "s3_semantic": { "kanit": "cikti yok", "karar": "unknown" } }, "studyDesignMatch": { "s1_index": { "kanit": "Derleme", "karar": "pass" }, "s2_rules": { "kanit": "Derleme", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "pass", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "unknown", "studyDesignMatch": "pass" }, "sourceHash": "4dcc201c0bd6", "taxonomy": { "clinicalModality": "ire", "electroporationRegime": "irreversible", "portalFocus": "komsu" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-00ad9fa30f59": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "0edd8889ae1c022a", "decisionsHash": "a286e3051043", 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"bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "karaciger-tumorleri", "karar": "pass" }, "s2_rules": { "kanit": "karaciger-tumorleri,kolon-ve-rektum-kanseri", "karar": "pass" }, "s3_semantic": { "kanit": "karaciger-tumorleri,kolon-ve-rektum-kanseri", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s1_mesh": { "kanit": "IRE", "karar": "pass" }, "s2_rules": { "kanit": "IRE", "karar": "pass" }, "s3_semantic": { "kanit": "IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh elektroporasyon terimi", "karar": "pass" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s1_mesh": { "kanit": 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Buna karsilik PubMed yayin tipi 'Randomized Controlled Trial'. 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Melanom yalnızca olası hedef örneği olarak anılıyor; yayının konusu elektrot/alan eşiği biyofiziği olduğundan alan 'genel-prensipler'dir.", "rationaleSource": "archived_model_output", "reasonCodes": [ "disease_area_signals_split", "study_design_single_signal_only", "document_type_single_signal_only", "correction_failed_revalidation" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=None", "karar": "unknown" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "malign-melanom", "karar": "fail" }, "s3_semantic": { "kanit": "malign-melanom", "karar": "pass" } }, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT,IRE", "karar": "pass" }, "s3_semantic": { "kanit": "ECT,IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "duzelt", "karar": "pass" } }, "studyDesignMatch": { "s3_semantic": { "kanit": "None", "karar": "pass" } } }, "signals": { "bibliographicMatch": "unknown", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "unknown" }, "sourceHash": "ceabacd8df15", "taxonomy": { "clinicalModality": "ire", "electroporationRegime": "irreversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "conflict", "validatorCodeHash": "501a37100441" }, "ref-09bdaf296054": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "ccdd881191ce94ec", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "'In this multi-center study ... we performed laparotomic and laparoscopic IRE in a total of 70 patients with stage III LAPC'.", "rationaleSource": "archived_model_output", "reasonCodes": [ "modality_signals_split", "document_type_single_signal_only", "study_design_single_signal_only" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "pankreas-kanseri", "karar": "pass" }, "s2_rules": { "kanit": "pankreas-kanseri", "karar": "pass" }, "s3_semantic": { "kanit": "pankreas-kanseri", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s1_mesh": { "kanit": "ECT", "karar": "fail" }, "s2_rules": { "kanit": "ECT,IRE", "karar": "pass" }, "s3_semantic": { "kanit": "ECT,IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh elektroporasyon terimi", "karar": "pass" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s3_semantic": { "kanit": "None", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "pass", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "pass", "studyDesignMatch": "unknown" }, "sourceHash": "abe636cc8f5c", "taxonomy": { "clinicalModality": "ire", "electroporationRegime": "irreversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-09c5e32d0ca5": { "correctionApplied": { "applicationSlug": "akciger-ve-peribronsiyal-tumorler" }, "countsTowardMaturity": false, "decisionCode": "b0fbf412e27a3689", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "Baslik 'a prospective multicenter phase II trial on lung malignancies' (ALICE), ozet 'To assess safety and efficacy of irreversible electroporation (IRE) of lung malignancies. Patients with primary and secondary lung malignancies ... were included' diyor; komplikasyonlar pnomotoraks/alveoler kanama. Tedavi edilen organ akcigerdir; kolorektal yalnizca metastazlarin primer kokenidir (13/23), calismanin alani degil.", "rationaleSource": "archived_model_output", "reasonCodes": [ "disease_area_signals_split", "document_type_single_signal_only", "disease_area_unverified", "correction_revalidated" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "akciger-ve-peribronsiyal-tumorler", "karar": "pass" }, "s2_rules": { "kanit": "kolon-ve-rektum-kanseri", "karar": "fail" }, "s3_semantic": { "kanit": "kolon-ve-rektum-kanseri", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT,IRE", "karar": "pass" }, "s3_semantic": { "kanit": "ECT,IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh elektroporasyon terimi", "karar": "pass" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s1_index": { "kanit": "Klinik Çalışma", "karar": "pass" }, "s1_mesh": { "kanit": "Klinik Çalışma", "karar": "pass" }, "s2_rules": { "kanit": "Prospektif Klinik Çalışma", "karar": "pass" }, "s3_semantic": { "kanit": "Prospektif Klinik Çalışma", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "pass" }, "sourceHash": "95d7d53a61bb", "taxonomy": { "clinicalModality": "ire", "electroporationRegime": "irreversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "auto_corrected", "validatorCodeHash": "501a37100441" }, "ref-09dcf5288c9e": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "50f305e0d29cfe08", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "Yöntem/protokol makalesi: 3D tümör sferoid kültür sisteminin kurulması ve kültür kuyucuğunda kullanılabilen el tipi özel elektrotların tarifi. Özet 'The customized electrodes are described in detail in order to facilitate the application of pulses in the culture well' diyor. Konu elektrot ve in vitro ECT yöntemi geliştirme; oküler melanom hücre hatları model olarak kullanılmış. Genel prensipler doğru.", "rationaleSource": "archived_model_output", "reasonCodes": [ "disease_area_contradicted_by_two_sources", "document_type_single_signal_only" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "malign-melanom", "karar": "fail" }, "s2_rules": { "kanit": "malign-melanom", "karar": "fail" }, "s3_semantic": { "kanit": "malign-melanom", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s1_mesh": { "kanit": "ECT", "karar": "pass" }, "s2_rules": { "kanit": "ECT", "karar": "pass" }, "s3_semantic": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh elektroporasyon terimi", "karar": "pass" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen 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"modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "Baslik 'Results from a Prospective Cohort'; goruntuleme sonlanimlarinin sagkalimla iliskisi incelenmis.", "rationaleSource": "archived_model_output", "reasonCodes": [ "document_type_single_signal_only" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "pankreas-kanseri", "karar": "pass" }, "s3_semantic": { "kanit": "pankreas-kanseri", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT,IRE", "karar": "pass" }, "s3_semantic": { "kanit": "ECT,IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s2_rules": { "kanit": "Prospektif Klinik Çalışma", "karar": "pass" }, "s3_semantic": { "kanit": "Prospektif Klinik Çalışma", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "pass", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "pass" }, "sourceHash": "830cee787b61", "taxonomy": { "clinicalModality": "ire", "electroporationRegime": "irreversible", "portalFocus": "cekirdek" }, "tierEligible": true, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "auto_confirmed", "validatorCodeHash": "501a37100441" }, "ref-0a088bd45c04": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "e8b0850d3214d94d", "decisionsHash": 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girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "cikti yok", "karar": "unknown" } }, "studyDesignMatch": { "s2_rules": { "kanit": "Vaka Raporu", "karar": "pass" } } }, "signals": { "bibliographicMatch": "unknown", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "unknown", "studyDesignMatch": "unknown" }, "sourceHash": "bbb05e6d0aef", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-0a2e2bb55777": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "08458f22293e9a30", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 0, 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"studyDesignMatch": { "s1_index": { "kanit": "Derleme", "karar": "pass" }, "s2_rules": { "kanit": "Hayvan Çalışması", "karar": "fail" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "unknown" }, "sourceHash": "e1e24244546e", "taxonomy": { "clinicalModality": "kalsiyum-elektroporasyonu", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-0a60751381a1": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "e2a47d1540a30fd0", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 0, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": 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"primaryRelevance": "unknown", "studyDesignMatch": "unknown" }, "sourceHash": "0780c85905f7", "taxonomy": { "clinicalModality": "diger-elektroporasyon", "electroporationRegime": "reversible", "portalFocus": "komsu" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-12ded6b39ad0": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "86633ca3ec8ca8b5", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 0, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "elektroporasyon başlıkta değerlendirilen girişim", "rationaleSource": "pipeline", "reasonCodes": [ "primary_relevance_single_signal_only", "modality_single_signal_only" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=None", "karar": "unknown" } }, "diseaseAreaMatch": {}, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT,IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "cikti yok", "karar": "unknown" } }, "studyDesignMatch": {} }, "signals": { "bibliographicMatch": "unknown", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "unknown", "studyDesignMatch": "unknown" }, "sourceHash": "38fac46e016d", "taxonomy": { "clinicalModality": "ire", "electroporationRegime": "irreversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-130051580ebf": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "c4b0fe2ce54f457c", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "PubMed kaydında özet yok; PMC13091296 tam metni makalenin özgün araştırma olduğunu, Tff1-Cre;LSL-Cas9 farelerinde mide mukozasına in vivo elektroporasyonla plazmid (sg-Trp53, LSL-Myc, LSL-Kras G12D) verilerek mide kanseri modeli üretildiğini gösteriyor. Bu nedenle 'Derleme' yanlış, tasarım 'Hayvan Çalışması'. Elektroporasyon tümör tedavisi olarak değil gen aktarım aracı olarak kullanıldığı ve taksonomide mide/üst GİS alanı bulunmadığı için uygulama alanı genel-prensipler olarak bırakıldı; tarayıcının önerdiği 'ozofagus-ve-ust-gi-tumorler' izinli alan kimlikleri arasında yok.", "rationaleSource": "archived_model_output", "reasonCodes": [ "modality_single_signal_only", "disease_area_signals_split", "study_design_signals_split", "document_type_single_signal_only", "correction_failed_revalidation" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "ozofagus-ve-ust-gi-tumorler", "karar": "fail" }, "s3_semantic": { "kanit": "ozofagus-ve-ust-gi-tumorler", "karar": "pass" } }, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, 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"validatorCodeHash": "501a37100441" }, "ref-132039040ca2": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "69f34d751320063c", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 0, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "elektroporasyon başlıkta değerlendirilen girişim", "rationaleSource": "pipeline", "reasonCodes": [ "study_design_single_signal_only" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": {}, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": {}, "primaryRelevance": { "s1_mesh": { "kanit": "mesh elektroporasyon terimi", "karar": "pass" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "cikti yok", "karar": "unknown" } }, "studyDesignMatch": { "s1_mesh": { "kanit": "Hayvan Çalışması", "karar": "fail" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "pass", "studyDesignMatch": "unknown" }, "sourceHash": "1372308eda0a", "taxonomy": { "clinicalModality": "diger-elektroporasyon", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-133153222206": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "d39c9d85ff53fd6d", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 0, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": 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"pass", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "unknown", "studyDesignMatch": "unknown" }, "sourceHash": "1b2afe104d0a", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-133ace2e4b1c": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "03579eb10ed82eaf", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "Başlık 'Irreversible electroporation treatment for prostate adenocarcinomas: a safety outcome study' diyor. Kayda yapıştırılan özet metni başka bildirilere ait (No. 264-265, biliyer girişimler ve kon-ışınlı BT) ve kayıt bu yüzden kolanjiokarsinom alanına düşmüş. Aynı nedenle tasarım okunamadığından studyDesign'a dokunulmadı.", "rationaleSource": "archived_model_output", "reasonCodes": [ "study_design_single_signal_only", "document_type_single_signal_only", "correction_failed_revalidation" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=None", "karar": "unknown" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "prostat-ve-urolojik-tumorler", "karar": "pass" }, "s3_semantic": { "kanit": "prostat-ve-urolojik-tumorler", "karar": "pass" } }, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT,IRE", "karar": "pass" }, "s3_semantic": { "kanit": "ECT,IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "duzelt", "karar": "pass" } }, "studyDesignMatch": { "s3_semantic": { "kanit": "None", "karar": "pass" } } }, "signals": { "bibliographicMatch": "unknown", "diseaseAreaMatch": "pass", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "unknown" }, "sourceHash": "369a0a27cbe6", "taxonomy": { "clinicalModality": "ire", "electroporationRegime": "irreversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "conflict", "validatorCodeHash": "501a37100441" }, "ref-134e65f2577b": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "04e03c2165277e4c", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "'We examined the influence 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"elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s3_semantic": { "kanit": "None", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "pass", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "unknown" }, "sourceHash": "f0910005b5f4", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-134e76dd053b": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "3f769e88aadae797", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", 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Hasta serisi ya da sonuc verisi yok; klinik calisma ve Insan modeli atamalari yanlis. 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IRE özette incelenen yeni teknolojilerden biri olarak yer alıyor ('Irreversible electroporation, although not strictly thermal, is a new technology showing promising results in animal and early human research'), yani elektroporasyonla karşılaştırılan yöntemleri anlatan kapsamda; korpusta kalır, ancak alanı renal/ürolojiktir.", "rationaleSource": "archived_model_output", "reasonCodes": [ "primary_relevance_signals_split", "modality_signals_split", "study_design_signals_split", "document_type_single_signal_only", "correction_failed_revalidation" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "prostat-ve-urolojik-tumorler", "karar": "pass" }, "s2_rules": { "kanit": "prostat-ve-urolojik-tumorler", "karar": "pass" }, "s3_semantic": { "kanit": "prostat-ve-urolojik-tumorler", "karar": "pass" } }, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s1_mesh": { "kanit": "ECT", "karar": "fail" }, "s2_rules": { "kanit": "ECT,IRE", "karar": "pass" }, "s3_semantic": { "kanit": "ECT,IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh elektroporasyon terimi", "karar": "pass" }, "s2_rules": { "kanit": "elektroporasyon incelenen girişim değil; gelecek önerisi=1", "karar": "fail", "rol": "gelecek_onerisi" }, "s3_semantic": { "kanit": "duzelt", "karar": "pass" } }, "studyDesignMatch": { "s1_index": { "kanit": "Derleme", "karar": "pass" }, "s2_rules": { "kanit": "Randomize Klinik Çalışma", "karar": "fail" }, "s3_semantic": { "kanit": "Randomize Klinik Çalışma", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "pass", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "unknown", "studyDesignMatch": "unknown" }, "sourceHash": "42a3658f5a31", "taxonomy": { "clinicalModality": "diger-elektroporasyon", "electroporationRegime": "reversible", "portalFocus": "komsu" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "conflict", "validatorCodeHash": "501a37100441" }, "ref-6f2b36405c93": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "8bda0f07e965d8b1", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 0, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "elektroporasyon başlıkta değerlendirilen girişim", "rationaleSource": "pipeline", "reasonCodes": [ "primary_relevance_single_signal_only", "modality_single_signal_only", "disease_area_single_signal_only", "disease_area_unverified" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=None", "karar": "unknown" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "pankreas-kanseri", "karar": "pass" } }, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "cikti yok", "karar": "unknown" } }, "studyDesignMatch": {} }, "signals": { "bibliographicMatch": "unknown", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "unknown", "studyDesignMatch": "unknown" }, "sourceHash": "bb8ca06d53fe", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-6f3787cc270c": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "71f478ab21c87f71", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 0, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "elektroporasyon başlıkta değerlendirilen girişim", "rationaleSource": "pipeline", "reasonCodes": [ "study_design_single_signal_only" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "malign-melanom", "karar": "pass" }, "s2_rules": { "kanit": "malign-melanom", "karar": "pass" } }, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s1_mesh": { "kanit": "ECT", "karar": "pass" }, "s2_rules": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh elektroporasyon terimi", "karar": "pass" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "cikti yok", "karar": "unknown" } }, "studyDesignMatch": { "s1_mesh": { "kanit": "Hayvan Çalışması", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "pass", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "unknown" }, "sourceHash": "1623e2caf1df", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-6f6ab64f79c1": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "6b5c27f5242771aa", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 0, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "elektroporasyon başlıkta değerlendirilen girişim", "rationaleSource": "pipeline", "reasonCodes": [ "primary_relevance_single_signal_only", "modality_single_signal_only", "disease_area_single_signal_only", "study_design_single_signal_only", "disease_area_unverified" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=0.917", "karar": "pass" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "meme-kanseri", "karar": "pass" } }, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "cikti yok", "karar": "unknown" } }, "studyDesignMatch": { "s2_rules": { "kanit": "İn Vitro Çalışma", "karar": "fail" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "unknown", "studyDesignMatch": "unknown" }, "sourceHash": "717a3186e36c", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-6f8eac1fadc0": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "a6a556c1042500b7", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 0, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "elektroporasyon başlıkta karşılaştırmalı değerlendirilen girişim", "rationaleSource": "pipeline", "reasonCodes": [ "primary_relevance_single_signal_only", "modality_single_signal_only", "disease_area_single_signal_only", "disease_area_unverified" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=None", "karar": "unknown" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "kemik-ve-yumusak-doku-sarkomlari", "karar": "pass" } }, "documentTypeMatch": {}, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta karşılaştırmalı değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "cikti yok", "karar": "unknown" } }, "studyDesignMatch": {} }, "signals": { "bibliographicMatch": "unknown", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "unknown", "primaryRelevance": "unknown", "studyDesignMatch": "unknown" }, "sourceHash": "bd2cf266d118", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "insufficient", "validatorCodeHash": "501a37100441" }, "ref-6fa7060514aa": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "5aa82000ad784fd3", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "Çalışmanın katkısı mikroakışkan platformun (hücre gradyan jeneratörü + ITO interdigital elektrotlar) geliştirilmesi ve hücre yoğunluğunun ECT sitotoksisitesini belirleyen bir faktör olduğunun gösterilmesi; özetin sonucu 'tumour cell density is one of the most factors for ECT treatment' biçiminde hastalıktan bağımsız. Meme kanseri hattı model sistem, hedef hastalık değil. Genel prensipler doğru.", "rationaleSource": "archived_model_output", "reasonCodes": [ "disease_area_signals_split", "document_type_single_signal_only" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "meme-kanseri", "karar": "fail" }, "s3_semantic": { "kanit": "meme-kanseri", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT", "karar": "pass" }, "s3_semantic": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s2_rules": { "kanit": "İn Vitro Çalışma", "karar": "pass" }, "s3_semantic": { "kanit": "İn Vitro Çalışma", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "pass" }, "sourceHash": "ab6b3fb0da4d", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "auto_confirmed", "validatorCodeHash": "501a37100441" }, "ref-6fb49b0f9c6b": { "correctionApplied": {}, "countsTowardMaturity": true, "decisionCode": "2bcc8dadf7545173", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "elektroporasyon başlıkta değerlendirilen girişim", "rationaleSource": "pipeline", "reasonCodes": [ "document_type_single_signal_only" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "bas-ve-boyun-tumorleri", "karar": "pass" }, "s2_rules": { "kanit": "bas-ve-boyun-tumorleri", "karar": "pass" }, "s3_semantic": { "kanit": "bas-ve-boyun-tumorleri", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s1_mesh": { "kanit": "ECT", "karar": "pass" }, "s2_rules": { "kanit": "ECT", "karar": "pass" }, "s3_semantic": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh elektroporasyon terimi", "karar": "pass" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", 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INSPECT veri tabanina ileriye donuk kayit.", "rationaleSource": "archived_model_output", "reasonCodes": [ "document_type_single_signal_only", "correction_revalidated" ], "relationConfidence": "medium", "relationEvidence": [ "ayni-ilk-yazar:matthiessen", "yil-farki:2", "dizinli-makale-ile-dizinsiz-kayit" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=None", "karar": "unknown" } }, "diseaseAreaMatch": { "s2_rules": { "kanit": "meme-kanseri", "karar": "pass" }, "s3_semantic": { "kanit": "meme-kanseri", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "ECT", "karar": "pass" }, "s3_semantic": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s2_rules": { "kanit": "Prospektif Klinik Çalışma", "karar": "pass" }, "s3_semantic": { "kanit": "Prospektif Klinik Çalışma", "karar": "pass" } } }, "signals": { "bibliographicMatch": "unknown", "diseaseAreaMatch": "pass", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "pass" }, "sourceHash": "34b3d494e4a5", "studyFamilyId": "aile-2a3f01316a", "studyRelation": "related-publication", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "auto_corrected", "validatorCodeHash": "501a37100441" }, "ref-b6fbd443b618": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "fadeec8d04bde06d", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "Derleme kemik metastazlarında (SRE, MESCC, patolojik kırık bağlamında) ECT'yi konu alıyor; primer kemik sarkomu yok. 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Kolanjiokarsinom calisilmiyor; safra yolu yalnizca 'important tissues such as blood vessel, bile duct, and nerve are preserved' cumlesinde geciyor. 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Sonuc verisi yok. 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Tarayıcının önerdiği 'ozofagus-ve-ust-gi-tumorler' ayrıca izinli alan listesinde yok. Kardiyak PFA güvenlik çalışması olarak kardiyak-pfa doğru.", "rationaleSource": "archived_model_output", "reasonCodes": [ "disease_area_signals_split", "document_type_single_signal_only", "disease_area_unverified" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "kardiyak-pfa", "karar": "pass" }, "s2_rules": { "kanit": "ozofagus-ve-ust-gi-tumorler", "karar": "fail" }, "s3_semantic": { "kanit": "ozofagus-ve-ust-gi-tumorler", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s2_rules": { "kanit": "IRE", "karar": "pass" }, "s3_semantic": { "kanit": "IRE", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh taniklik etmiyor", "karar": "unknown" }, "s2_rules": { "kanit": "elektroporasyon başlıkta karşılaştırmalı değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s1_mesh": { "kanit": "Hayvan Çalışması", "karar": "pass" }, "s3_semantic": { "kanit": "None", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "pass" }, "sourceHash": "a8a42f5b2c99", "taxonomy": { "clinicalModality": "pfa", "electroporationRegime": "irreversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "auto_confirmed", "validatorCodeHash": "501a37100441" }, "ref-dbac920963f4": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "51a8688a6ba2a7fb", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "elektroporasyon başlıkta değerlendirilen girişim", "rationaleSource": "pipeline", "reasonCodes": [ "disease_area_signals_split", "document_type_single_signal_only", "disease_area_unverified" ], "rulesetHash": "4d3e5c6f87c3", "signalSources": { "bibliographicMatch": { "s1_index": { "kanit": "baslik ortusmesi=1.0", "karar": "pass" } }, "diseaseAreaMatch": { "s1_mesh": { "kanit": "cilt-ve-kutanoz-tumorler", "karar": "fail" }, "s2_rules": { "kanit": "bas-ve-boyun-tumorleri", "karar": "pass" }, "s3_semantic": { "kanit": "bas-ve-boyun-tumorleri", "karar": "pass" } }, "documentTypeMatch": { "s3_semantic": { "kanit": "-", "karar": "pass" } }, "identifierPresent": { "s1_index": { "kanit": "doi", "karar": "pass" } }, "modalityMatch": { "s1_mesh": { "kanit": "ECT", "karar": "pass" }, "s2_rules": { "kanit": "ECT", "karar": "pass" }, "s3_semantic": { "kanit": "ECT", "karar": "pass" } }, "primaryRelevance": { "s1_mesh": { "kanit": "mesh elektroporasyon terimi", "karar": "pass" }, "s2_rules": { "kanit": "elektroporasyon başlıkta değerlendirilen girişim", "karar": "pass", "rol": "incelenen_girisim" }, "s3_semantic": { "kanit": "dogru", "karar": "pass" } }, "studyDesignMatch": { "s1_index": { "kanit": "Klinik Çalışma", "karar": "pass" }, "s3_semantic": { "kanit": "None", "karar": "pass" } } }, "signals": { "bibliographicMatch": "pass", "diseaseAreaMatch": "unknown", "documentTypeMatch": "unknown", "identifierPresent": "pass", "modalityMatch": "pass", "primaryRelevance": "pass", "studyDesignMatch": "pass" }, "sourceHash": "c9e163095898", "taxonomy": { "clinicalModality": "elektrokemoterapi", "electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "auto_confirmed", "validatorCodeHash": "501a37100441" }, "ref-dbbebcd68740": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "95f00c15a03e6f45", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "Plazmid tümöre değil normal kas dokusuna (tibialis cranialis) elektrotransfer ediliyor ve ölçülen şey IL-12'nin serumda kontrollü sistemik salınımı ile ışınlamayla etkileşimi; SA-1 ve LPB murin tümörleri ile akciğer metastazları yalnızca etkinlik göstergesi. 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"electroporationRegime": "reversible", "portalFocus": "cekirdek" }, "tierEligible": false, "validatedAt": "2026-08-24", "validationProcess": "ect-automated-validation", "validationStatus": "conflict", "validatorCodeHash": "501a37100441" }, "ref-e2cabf3c9d60": { "correctionApplied": {}, "countsTowardMaturity": false, "decisionCode": "b094dfc7387813fa", "decisionsHash": "a286e3051043", "interventionRole": "incelenen_girisim", "modelId": "claude-opus-5", "modelRuns": 1, "processVersion": "3.0.0", "promptHash": "e1bd7aa07ee2", "rationale": "Kemik/yumuşak doku sarkomuyla hiçbir ilgisi yok. Yayının konusu bir ölçüm düzeneği: kollajen hidrojel tabanlı 3D hücre fantomunda EP sonrası sıcaklık artışı ve hücre canlılığı değerlendiriliyor ve ana sonuç 'The thermal effect due to EP cannot be neglected and it has to be discussed if this technique is non-thermal' şeklinde yöntem/mekanizma düzeyinde. Akciğer hücre hattı (HCC-827) yalnızca model, klinik akciğer uygulaması anlatılmıyor; fantom ve elektrot materyali geliştirme kapsamı genel-prensiplere girer. 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